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Corneal crosslinking

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https://www.readbyqxmd.com/read/28917412/efficacy-of-different-accelerated-corneal%C3%A2-crosslinking-protocols-for%C3%A2-progressive-keratoconus
#1
Ebru Toker, Eren Çerman, Deniz Özarslan Özcan, Özge Begüm Seferoğlu
PURPOSE: To evaluate the efficacy of different accelerated corneal crosslinking (CXL) treatment protocols in patients with progressive keratoconus. SETTING: Marmara University School of Medicine, Istanbul, Turkey. DESIGN: Retrospective case series. METHODS: Patients with progressive keratoconus had 9 mW accelerated CXL (10 minutes; 9 mW/cm(2)), 30 mW continuous-light accelerated CXL (4 minutes; 30 mW/cm(2)), or 30 mW pulsed-light accelerated CXL (8 minutes [1 second on/1 second off]; 30 mW/cm(2))...
August 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28917411/accelerated-15%C3%A2-mw-pulsed-light-crosslinking-to-treat-progressive-keratoconus-two-year-clinical-results
#2
Cosimo Mazzotta, Stefano Baiocchi, Simone Alex Bagaglia, Mario Fruschelli, Alessandro Meduri, Miguel Rechichi
PURPOSE: To assess the clinical and microstructural results of accelerated 15 mW pulsed-light corneal crosslinking (CXL) to treat progressive keratoconus. SETTING: Siena Crosslinking Center, Siena, Italy. DESIGN: Prospective case series. METHODS: After epithelium removal (with Epi-Clear) and 10 minutes stromal soaking with riboflavin 0.1% hydroxypropyl methylcellulose solution, all eyes had 15 mW/cm(2) pulsed-light epithelium-off accelerated CXL for 6 minutes of ultraviolet-A (UVA) irradiation (1 second on/1 second off), maintaining a total UVA exposure of 12 minutes at a fluence of 5...
August 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28875112/bilateral-corneal-perforation-due-to-mrsa-keratitis-in-a-crosslinking-patient
#3
Zackery Oakey, Kevin Thai, Sumit Garg
Introduction: The cornea may become infected and perforated after epithelium-on collagen crosslinking. Case presentation: A healthy 33-year-old male who underwent corneal collagen crosslinking in both eyes developed a purulent keratitis and bilateral corneal perforations, requiring bilateral penetrating keratoplasties. He was exposed to methicillin resistant staphylococcus aureus (MRSA) by a family member with a tracheostomy and was treated with MRSA-directed antibiotics. After prolonged recovery and treatment of his infection, he had acceptable but limited uncorrected visual acuity, with excellent corrected visual acuity...
2017: GMS Ophthalmology Cases
https://www.readbyqxmd.com/read/28864177/corneoscleral-stiffening-increases-iop-spike-magnitudes-during-rapid-microvolumetric-change-in-the-eye
#4
Keyton Clayson, Xueliang Pan, Elias Pavlatos, Ryan Short, Hugh Morris, Richard T Hart, Jun Liu
Factors governing the steady-state IOP have been extensively studied; however, the dynamic aspects of IOP are less understood. Clinical studies have suggested that intraocular pressure (IOP) fluctuation may be associated with glaucoma risk. This study aims to investigate how stiffening of corneoscleral biomechanical properties affects IOP spikes induced by rapid microvolumetric change. Porcine eyes (n = 25 in total) were subjected to volumetric infusions before and after external treatment of a circular area (11 mm diameter) in either the central cornea or posterior sclera...
August 30, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28864070/pediatric-corneal-crosslinking-comparison-of-visual-and-topographic-outcomes-between-conventional-and-accelerated-treatment
#5
Philipp B Baenninger, Lucas M Bachmann, Ludmilla Wienecke, Michael A Thiel, Claude Kaufmann
PURPOSE: To compare visual and topographic outcomes 1 year after conventional (C-CXL) versus accelerated corneal crosslinking (A-CXL) in pediatric keratoconus DESIGN: Comparative, retrospective, consecutive case-series METHODS: Patients with topography confirmed, progressive KC and a corneal thickness of ≥400 micrometers at the time of surgery were enrolled. Uncorrected (UCVA) and best phoropter-corrected visual acuity (BCVA) and Kmax were measured at study entry and the 12-months follow-up...
August 29, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28855517/cross-linked-decellularized-porcine-corneal-graft-for-treating-fungal-keratitis
#6
Yongliang Lin, Qinxiang Zheng, Shanshan Hua, Yongchun Meng, Wei Chen, Yifei Wang
This study aims to develop a cross-linked decellularized porcine corneal graft (cDPC) as a substitute for lamellar donor corneas and to evaluate the feasibility of using cDPC to treat fungal keratitis. The cDPC was prepared by decellularization, chemical crosslinking and γ-ray irradiation. Transparency, effectiveness of decellularization and biomechanical strength of cDPC were evaluated. The safety and efficacy of using cDPC to treat fungal keratitis were evaluated in the rabbit model. The transparency of cDPC was similar to that of a native porcine cornea (NPC), and no intact cells were observed in cDPC except for an insignificant amount of residual shrinking cellular nucleus...
August 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28811773/transepithelial-corneal-crosslinking-in-treatment-of-progressive-keratoconus-12-months-clinical-results
#7
Bushra Akbar, Rana Intisar-Ul-Haq, Mazhar Ishaq, Sabahat Arzoo, Kashif Siddique
OBJECTIVE: The purpose of this study was to evaluate the safety and efficacy of transepithelial corneal collagen cross linking (TE-CXL) with modified riboflavin and accelerated UVA irradiance in thin corneas with pachymetry less than 400 microns at thinnest point, untreatable by epithelium off corneal collagen cross linking (CXL) in adult Pakistani population with progressive keratoconus. METHODS: This quasi experimental study included twenty six eyes of 26 patients with progressive keratoconus who underwent accelerated transepithelial CXL in Armed forced institute of ophthalmology with 12 months follow up...
May 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28777385/efficacy-of-eyedrops-containing-cross-linked-hyaluronic-acid-and-coenzyme-q10-in-treating-patients-with-mild-to-moderate-dry-eye
#8
Elisa I Postorino, Laura Rania, Emanuela Aragona, Carmen Mannucci, Angela Alibrandi, Gioacchino Calapai, Domenico Puzzolo, Pasquale Aragona
PURPOSE: Dry eye disease (DED) is a common condition causing substantial burden. A randomized, controlled, single-masked study was performed in 40 patients with mild to moderate DED to evaluate the efficacy and safety of a collyrium based on crosslinked hyaluronic acid (XLHA) with coenzyme Q10 (CoQ10). METHODS: Enrolled subjects were divided into 2 groups: group A, treated with XLHA + CoQ10; and group B, treated with hyaluronic acid (HA). Eyedrops were administered 4 times daily for 3 months...
August 2, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28763562/chondroitin-sulfate-based-biocompatible-crosslinker-restores-corneal-mechanics-and-collagen-alignment
#9
Xiaokun Wang, Shoumyo Majumdar, Garret Ma, Jeeyeon Sohn, Samuel C Yiu, Walter Stark, Awad Al-Qarni, Deepak P Edward, Jennifer H Elisseeff
Purpose: To evaluate the crosslinking effect of functionalized chondroitin sulfate (CS) in an ex vivo rabbit cornea model. Methods: Chondroitin sulfate molecules were chemically modified with the N-hydroxysuccinimide (NHS) group. Enucleated rabbit eyes were crosslinked with 2, 5, or 10 mg/mL CS-NHS solution for 30 or 60 minutes. The CS-NHS penetration, corneal swelling ratio, Young's modulus, and ultrastructure of the crosslinked corneas were characterized. In addition, rabbit corneas were further treated with a collagenase-chondroitinase solution to create an ex vivo keratoconus (KC)-like model...
August 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28761323/the-comparative-safety-of-genipin-versus-uva-riboflavin-crosslinking-of-rabbit-corneas
#10
Wenjing Song, Yun Tang, Jing Qiao, Haili Li, Bei Rong, Songlin Yang, Yuan Wu, Xiaoming Yan
PURPOSE: To investigate, after 24 h, the safety of genipin or ultraviolet A (UVA)-riboflavin crosslinking of keratocytes and endothelial cells. METHODS: Fifteen New Zealand white rabbits were selected and divided into a PBS group (five rabbits), a 0.2% genipin crosslinking (GP-CXL) group (five rabbits), and a UVA-riboflavin crosslinking (UVA-CXL) group (five rabbits). In the GP-CXL and PBS groups, 0.2% genipin or PBS was applied to the corneal surface of the right eyes...
2017: Molecular Vision
https://www.readbyqxmd.com/read/28758436/-diagnostics-and-treatment-of-infectious-keratitis
#11
Nóra Szentmáry, László Módis, László Imre, Ágnes Füst, Loay Daas, Lenke Laurik, Berthold Seitz, Zoltán Zsolt Nagy
We summarize up-to-date diagnostic and treatment of infectious keratitis using literature data and some clinical examples. In the clinical practice, most commonly bacterial, herpetic, mycotic and acanthamoeba keratitis occur. Beside slitlamp examination, for diagnostic purpose, we analyse corneal sensitivity, perform in vivo confocal microscopy, polymerase-chain-reaction (PCR), in vitro culture and histological examination of the corneal sample. As conservative treatment we use primarily topical moxifloxacin or cephasolin with fortified tobramycin or gentamycin in bacterial, topical antiviral gel (in some cases in combination with systemic antiviral treatment) in part in combination with topical corticosteroids in herpetic, voriconasole or amphotericin-B in mycotic, and topical-triple-therapy (diamidine, biguanid and antibiotics) in acanthamoeba keratitis...
August 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28747621/evaluation-of-biomechanical-changes-in-myopia-patients-with-unsatisfactory-corneas-after-femto-second-laser-in-situ-keratomileusis-fs-lasik-concurrent-with-accelerated-corneal-collagen-cross-linking-using-corvis-st-two-year-follow-up-results
#12
Weiwei Xu, Ye Tao, Liqiang Wang, Yifei Huang
BACKGROUND Some myopia patients with unsatisfactory corneas consider corneal refractive surgery for different reasons. Accelerated corneal collagen crosslinking (ACXL) is an effective method to enhance the resistance of the cornea. The present investigation was designed to evaluate the changes of biomechanical properties in patients with myopia and thin corneas after femtosecond-laser in situ keratomileusis (FS-LASIK) concurrent with ACXL. MATERIAL AND METHODS A prospective study was designed. A total of 22 eyes of 11 myopia astigmatism patients with unsatisfactory corneas were enrolled...
July 27, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28745658/-results-of-corneal-crosslinking-for-pellucid-marginal-corneal-degeneration
#13
M M Bikbov, V K Surkova, A R Khalimov, E L Usubov
AIM: to evaluate the clinical effectiveness of crosslinking in patients with progressive pellucid marginal corneal degeneration (PMCD). MATERIAL AND METHODS: A total of 9 patients (16 eyes) with progressive PMCD were treated by standard crosslinking. The cornea was saturated with Dextralink solution and UV-A irradiated at 3 mW/cm2 for 30 minutes. The follow-up period was 12 months. RESULTS: One month after treatment, there was a slight decrease in uncorrected and best corrected visual acuity (UCVA and BCVA) - from 0...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/28732613/photorefractive-intrastromal-corneal-crosslinking-for-the-treatment-of-myopic-refractive-errors-six-month-interim-findings
#14
Matthias Elling, Inga Kersten-Gomez, H Burkhard Dick
PURPOSE: To evaluate the safety and efficacy of photorefractive intrastromal corneal crosslinking (CXL) in low myopia. SETTING: Ruhr University Eye Hospital, Bochum, Germany. DESIGN: Prospective case series. METHODS: Healthy eyes with myopia or myopic astigmatism had photorefractive intrastromal CXL using the Mosaic system to apply ultraviolet-A (UVA) 365 nm (30 mW/cm(2)) irradiance (total calculated UVA dose of 10 J/cm(2) or 15 J/cm(2)) with riboflavin 0...
June 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28700779/corneal-wound-repair-after-rose-bengal-and-green-light-crosslinking-clinical-and-histologic-study
#15
Patricia Gallego-Muñoz, Lucía Ibares-Frías, Elvira Lorenzo, Susana Marcos, Pablo Peréz-Merino, Nandor Bekesi, Irene E Kochevar, M Carmen Martínez-García
Purpose: To evaluate corneal wound healing after treatment with a new collagen crosslinking protocol using rose bengal dye and green light (RGX). Methods: One cornea of 20 New Zealand rabbits was de-epithelialized (DE) in an 8-mm diameter circle and, in another group (n = 25), the DE corneas were then stained with 0.1% rose bengal for 2 minutes and exposed to green light (532 nm) for 7 minutes (RGX). The contralateral eyes without treatment acted as controls. The animals were clinically followed including fluorescein staining and pachymetry...
July 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28683485/-therapeutic-options-in-keratoconus
#16
Frederik Raiskup, Janine Lenk, Robert Herber, Zisis Gatzioufas, Eberhard Spörl
A recent epidemiology study revealed that prevalence of keratoconus was much higher than previously assumed. Therefore, it is no longer deemed an "orphan disease", as it has a relevant socioeconomic impact on the healthcare system. One of the most important risk factors for developing keratoconus is chronic eye rubbing which, apart from other known risk factors such as atopy or Down's syndrome, is the only modifiable factor. Informing the patient and offering behavior modifying therapies seems to be essential...
July 6, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28655538/u-s-multicenter-clinical-trial-of-corneal-collagen-crosslinking-for-treatment-of-corneal-ectasia-after-refractive-surgery
#17
Peter S Hersh, R Doyle Stulting, David Muller, Daniel S Durrie, Rajesh K Rajpal
PURPOSE: To evaluate the safety and efficacy of corneal collagen crosslinking (CXL) for the treatment of corneal ectasia after laser refractive surgery. DESIGN: Prospective, randomized, multicenter, controlled clinical trial. PARTICIPANTS: One hundred seventy-nine subjects with corneal ectasia after previous refractive surgery. METHODS: The treatment group underwent standard CXL, and the sham control group received riboflavin alone without removal of the epithelium...
June 24, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28644862/high-intensity-corneal-collagen-crosslinking-with-riboflavin-and-uva-in-rat-cornea
#18
Yirui Zhu, Peter S Reinach, Hanlei Zhu, Qiufan Tan, Qinxiang Zheng, Jia Qu, Wei Chen
Corneal collagen cross-linking (CXL) halts human corneal ectasias progression by increasing stromal mechanical stiffness. Although some reports describe that this procedure is effective in dealing with some infectious and immunologic corneal thinning diseases, there is a need for more animal models whose corneal thickness more closely resemble those occurring in these patients. To meet this need, we describe here high-intensity protocols that are safe and effective for obtaining CXL in rat corneas. Initially, a range of potentially effective UVA doses were evaluated based on their effectiveness in increasing tissue enzymatic resistance to dissolution...
2017: PloS One
https://www.readbyqxmd.com/read/28643721/surgical-treatment-of-metarhizium-anisopliae-sclerokeratitis-and-endophthalmitis
#19
Dan Derhy, Arnaud Sauer, Marcela Sabou, Jonathan Letsch, Ermanno Candolfi, Valérie Letscher-Bru, Tristan Bourcier
A 55-year-old nurse was referred with a 5-month history of right eye corneal abscess. The initial injury occurred when doing lawn work. The infection worsened despite multiple antibiotic, antiviral, and steroid treatments. Visual acuity was limited to hand motion. On examination, there was keratitis, ocular hypertension, and a secondary cataract. Corneal scrapings grew a filamentous fungus, identified as Metarhizium anisopliae (MA). Despite intensive antifungal treatment with topical, intravitreous, and systemic voriconazole, purulent corneal melting and scleritis with endophthalmitis rapidly appeared...
June 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28643528/modulating-release-of-ranibizumab-and-aflibercept-from-thiolated-chitosan-based-hydrogels-for-potential-treatment-of-ocular-neovascularization
#20
Miguel Moreno, Poh Yih Pow, Tan Su Teng Tabitha, Sonali Nirmal, Andreas Larsson, Krishna Radhakrishnan, Jayabalan Nirmal, Soo Tng Quah, Susana Geifman Shochat, Rupesh Agrawal, Subbu Venkatraman
BACKGROUND: This paper describes the synthesis of thiolated chitosan-based hydrogels with varying degrees of crosslinking that has been utilized to modulate release kinetics of two clinically relevant FDA-approved anti-VEGF protein drugs, ranibizumab and aflibercept. These hydrogels have been fabricated into disc shaped structures for potential use as patches on ocular surface. METHODS: Protein conformational changes and aggregation after loading and release was evaluated by circular dichroism (CD), steady-state tryptophan fluorescence spectroscopy, electrophoresis and size-exclusion chromatography (SEC)...
July 3, 2017: Expert Opinion on Drug Delivery
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