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Corneal crosslinking

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https://www.readbyqxmd.com/read/28079590/the-evaluation-of-corneal-fragility-after-uva-riboflavin-crosslinking
#1
Zhiwei Li, Yumeng Wang, Yanyun Xu, Vishal Jhanji, Chunxiao Zhang, Guoying Mu
PURPOSE: To evaluate the fragility of cornea after UVA/riboflavin crosslinking (CXL). METHODS: Sixty New Zealand rabbits received UVA/riboflavin crosslinking treatment (wavelength 365 nm, irradiance 3.0 mW/cm, and total dose 5.4 J/cm) on right eyes. Animals were sacrificed before and immediately after treatment (day 0), day 1, 3, 7, and 28 after treatment. A 4×10 mm corneal strip for biomechanical evaluation was harvested after sacrifice. The corneal fragility was evaluated by measurement of elongation rate, whereby the elongation rate equals elongation length/baseline length...
January 10, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28061402/sequentially-crosslinked-bioactive-hydrogels-as-nano-patterned-substrates-with-customizable-stiffness-and-degradation-for-corneal-tissue-engineering-applications
#2
Muhammad Rizwan, Gary S L Peh, Heng-Pei Ang, Nyein Chan Lwin, Khadijah Adnan, Jodhbir S Mehta, Wui Siew Tan, Evelyn K F Yim
Naturally-bioactive hydrogels like gelatin provide favorable properties for tissue-engineering but lack sufficient mechanical strength for use as implantable tissue engineering substrates. Complex fabrication or multi-component additives can improve material strength, but often compromises other properties. Studies have shown gelatin methacrylate (GelMA) as a bioactive hydrogel with diverse tissue growth applications. We hypothesize that, with suitable material modifications, GelMA could be employed for growth and implantation of tissue-engineered human corneal endothelial cell (HCEC) monolayer...
December 23, 2016: Biomaterials
https://www.readbyqxmd.com/read/28055060/optical-coherence-elastography-for-evaluating-customized-riboflavin-uv-a-corneal-collagen-crosslinking
#3
Manmohan Singh, Jiasong Li, Srilatha Vantipalli, Zhaolong Han, Kirill V Larin, Michael D Twa
No abstract text is available yet for this article.
September 1, 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28009397/corneal-collagen-crosslinking-for-corneal-ectasias-a-review
#4
David P S O'Brart
PURPOSE: To review the published literature on corneal collagen crosslinking (CXL). METHODS: Importance has been placed on seminal publications, systemic reviews, meta-analyses, and randomized controlled clinical trials. Where such evidence was not available, cohort studies, case-controlled studies, and case series with follow-up greater than 12 months were examined. RESULTS: Corneal collagen crosslinking with riboflavin and ultraviolet A (UVA) 370 nm radiation appears to be capable of arresting the progression of ectatic corneal disorders, with most studies reporting significant improvements in visual, keratometric, and topographic measurements...
December 6, 2016: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28007116/accelerated-corneal-collagen-crosslinking-technique-efficacy-safety-and-applications
#5
REVIEW
Carla S Medeiros, Natalia T Giacomin, Renata L Bueno, Ramon C Ghanem, Haroldo V Moraes, Marcony R Santhiago
: Corneal collagen crosslinking (CXL) is an approach used to increase the biomechanical stability of the stromal tissue. Over the past 10 years, it has been used to halt the progression of ectatic diseases. According to the photochemical law of reciprocity, the same photochemical effect is achieved with reduced illumination time and correspondingly increased irradiation intensity. Several new CXL devices offer high ultraviolet-A irradiation intensity with different time settings. The main purpose of this review was to discuss the current use of different protocols of accelerated CXL and compare the efficacy and safety of accelerated CXL with the efficacy and safety of the established conventional method...
December 2016: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28003986/therapeutic-and-inducing-effect-of-corneal-crosslinking-on-infectious-keratitis
#6
REVIEW
Liang-Zhu Jiang, Shi-Yan Qiu, Zhi-Wei Li, Xiao Zhang, Xiang-Chen Tao, Guo-Ying Mu
The corneal crosslinking (CXL) with riboflavin and ultraviolet-A (UVA) is a new therapy method to successfully treat infectious keratitis in clinical practice. However, there are rare reports on the complications of CXL such as the secondary keratitis. The diverse clinical outcomes on keratitis have highlighted the necessity to further evaluate the efficacy and complications of CXL. We reviewed the positive and negative reports on UVA/riboflavin related with keratitis and provided our opinion on the therapeutic and side effect of UVA/riboflavin crosslinking on keratitis...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/27956294/nonlinear-optical-corneal-collagen-crosslinking-of-ex%C3%A2-vivo-rabbit-eyes
#7
Samantha M Bradford, Donald J Brown, Tibor Juhasz, Eric Mikula, James V Jester
PURPOSE: To determine whether riboflavin-induced collagen crosslinking (CXL) could be precisely achieved in the corneal stroma of ex vivo rabbit eyes using nonlinear optical excitation with a low numerical aperture lens and enlarged focal volume. SETTING: Gavin Herbert Eye Institute, University of California Irvine, Irvine, California, USA. DESIGN: Experimental study. METHODS: The corneal epithelium was removed and the corneas were soaked in 0...
November 2016: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/27926752/corneal-resistance-to-keratolysis-after-collagen-crosslinking-with-rose-bengal-and-green-light
#8
Ali Fadlallah, Hong Zhu, Samer Arafat, Irene Kochevar, Samir Melki, Joseph B Ciolino
Purpose: The purpose of this study was to evaluate the resistance to degradation by collagenase A of corneas that have been crosslinked with Rose Bengal and green light (RGX). Methods: The ex vivo crosslinking procedure was performed on enucleated rabbit corneas. Corneas were deepithelialized after applying 30% alcohol. Corneas were stained with Rose Bengal (RB, 0.1%) for 2 minutes and then exposed to green light (532 nm) at 0.25 W/cm2 for times to deliver doses of 50, 100, 150, or 200 J/cm2 (n = 5 per group)...
December 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27899371/refractive-improvements-and-safety-with-topography-guided-corneal-crosslinking-for-keratoconus-1-year-results
#9
Maria Nordström, Maria Schiller, Anneli Fredriksson, Anders Behndig
PURPOSE: To assess the refractive improvements and the corneal endothelial safety of an individualised topography-guided regimen for corneal crosslinking in progressive keratoconus. METHODS: An open-label prospective randomised clinical trial was performed at the Department of Clinical Sciences, Ophthalmology, Umeå University Hospital, Umeå, Sweden. Thirty-seven patients (50 eyes) with progressive keratoconus planned for corneal crosslinking were included. The patients were randomised to topography-guided crosslinking (photorefractive intrastromal crosslinking (PiXL); n=25) or uniform 9 mm crosslinking (corneal collagen crosslinking (CXL); n=25)...
November 29, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27794469/tomographic-indices-as-possible-risk-factors-for-progression-in-pediatric-keratoconus
#10
Alexander Hamilton, Scott Wong, Fiona Carley, Nadia Chaudhry, Susmito Biswas
PURPOSE: To determine whether corneal tomography can help predict the risk of progression of keratoconus in children. METHODS: The medical records of pediatric patients with keratoconus presenting to a large tertiary institution in the UK from 2009 to 2014 were reviewed retrospectively. Patients underwent serial clinical examination and corneal tomography. The minimum follow-up period was 5 months. Patients with a history of eye surgery including corneal crosslinking were excluded...
December 2016: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/27767357/laser-vision-correction-with-q-factor-modification-for-keratoconus-management
#11
Natasha Kishore Pahuja, Rohit Shetty, Abhijit Sinha Roy, Maithil Mukesh Thakkar, Chaitra Jayadev, Rudy Mma Nuijts, Harsha Nagaraja
PURPOSE: To evaluate the outcomes of corneal laser ablation with Q factor modification for vision correction in patients with progressive keratoconus. METHODS: In this prospective study, 50 eyes of 50 patients were divided into two groups based on Q factor (>-1 in Group I and ≤-1 in Group II). All patients underwent a detailed ophthalmic examination including uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), subjective acceptance and corneal topography using the Pentacam...
October 21, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27710923/in-vitro-characterization-of-electrochemically-compacted-collagen-matrices-for-corneal-applications
#12
Vipuil Kishore, Ranjani Iyer, Athela Frandsen, Thuy-Uyen Nguyen
Loss of vision due to corneal disease is a significant problem worldwide. Transplantation of donor corneas is a viable treatment option but limitations such as short supply and immune-related complications call for alternative options for the treatment of corneal disease. A tissue engineering-based approach using a collagen scaffold is a promising alternative to develop a bioengineered cornea that mimics the functionality of native cornea. In this study, an electrochemical compaction method was employed to synthesize highly dense and transparent collagen matrices...
October 6, 2016: Biomedical Materials
https://www.readbyqxmd.com/read/27648049/corneal-collagen-cross-linking-cxl-in-treatment-of-pseudophakic-bullous-keratopathy
#13
Muhammad Saim Khan, Imran Basit, Mazhar Ishaq, Tariq Shakoor, Amer Yaqub, Rana Intisar
OBJECTIVE: To determine mean change in visual acuity, central corneal thickness and symptoms in patients with pseudophakic bullous keratopathy after treatment with corneal collagen crosslinking. METHODS: This quasi experimental study was conducted at Armed Forces Institute of Ophthalmology, Rawalpindi, Pakistan from April 2015 to Nov 2015. A total of 24 eyes of 24 patients were included in the study. Visual symptoms were graded in five grades (Grade 1-5), Grade-1 being very mild with decreased vision only while patients with all five symptoms (decreased vision, foreign body sensations, pain, watering and photophobia) were graded as Grade-5...
July 2016: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/27613085/characterization-of-rabbit-corneas-subjected-to-stromal-stiffening-by-the-a%C3%A3-a%C3%A3-extract-euterpe-oleracea
#14
Patrícia A Bersanetti, Tatiane L N Bueno, Andreia de A Morandim-Giannetti, Regina F Nogueira, Jivaldo R Matos, Paulo Schor
PURPOSE: In this study, we characterized rabbit corneas subjected to corneal cross-linking (CXL) with açaí extract compared with a riboflavin photo-stimulated procedure. MATERIALS AND METHODS: The corneas of the slaughterhouse rabbits were divided into three groups: control, consisting of untreated corneal samples; riboflavin/UVA, where corneas were treated with 0.1% riboflavin photo-stimulated at 365 nm as the standard protocol; and açaí, where the samples were subjected to 4% açaí extract for 0...
September 9, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27610144/norfloxacin-loaded-ph-triggered-nanoparticulate-in-situ-gel-for-extraocular-bacterial-infections-optimization-ocular-irritancy-and-corneal-toxicity
#15
Preeti Upadhayay, Manish Kumar, Kamla Pathak
In order to achieve prolong corneal contact time of norfloxacin (NFX) for treatment of extra ocular diseases, a pH triggered nanoparticulate in-situ gelling system was designed to explore dual advantage of nanoparticles and in-situ gelling system, for its ocular delivery. NFX loaded nanocarriers were developed by ionotropic gelation technique using chitosan as a matrix forming polymer, cross-linked by an anionic crosslinker sodium tripolyphosphate (TPP). Optimization of nanoformulations was done by 3(2) full factorial design using chitosan and TPP concentration(s) as the independent variables and particle size, % entrapment efficiency and % cumulative drug release as the responses...
2016: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/27602074/combining-corneal-crosslinking-and-phakic-toric-implantable-collamer-lenses-for-the-treatment-of-keratectasia-a-case-report
#16
Xiao Zhang, Xiang-Chen Tao, Zhi-Wei Li, Wei-Yan Zhou, Ping Ma, Chun-Xiao Zhang, Yu-Meng Wang, Guo-Ying Mu
The present study reports the use of a phakic toric Implantable Collamer Lens (ICL) that improved the refraction correction of high myopia and astigmatism in a case of keratectasia following corneal cross-linking. A 31-year-old male was diagnosed with keratectasia 12 years after laser-assisted in situ keratomileusis (LASIK). Following LASIK, the manifest refraction was -3.50-2.25×90 [0.1 logarithmic expression (LogMAR) best corrected visual acuity (BVCA)] in the right eye and -8.00-3.50×175 (0.3 LogMAR BCVA) in the left eye, with a LogMAR uncorrected distance visual acuity (UDVA) of 0...
September 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27583797/comparison-of-the-demarcation-line-on-asoct-after-simultaneous-lasik-and-different-protocols-of-accelerated-collagen-crosslinking-a-bilateral-eye-randomized-study
#17
Alex L K Ng, Peter S K Kwok, Ricky T K Wu, Vishal Jhanji, Victor C P Woo, Tommy C Y Chan
PURPOSE: To compare the demarcation line depth after 2 different protocols of simultaneous laser in situ keratomileusis and collagen crosslinking (LASIK Xtra). METHODS: Twenty-three patients receiving bilateral LASIK Xtra were included in this comparative interventional study. The corneal stroma was soaked with 0.22% riboflavin for 90 seconds before flap repositioning. One eye was then randomized to receive either 18 mW/cm of ultraviolet A irradiation for 120 seconds or for 180 seconds, whereas the fellow eye received the other irradiation duration...
January 2017: Cornea
https://www.readbyqxmd.com/read/27547022/noncontact-elastic-wave-imaging-optical-coherence-elastography-for-evaluating-changes-in-corneal-elasticity-due-to-crosslinking
#18
Manmohan Singh, Jiasong Li, Srilatha Vantipalli, Shang Wang, Zhaolong Han, Achuth Nair, Salavat R Aglyamov, Michael D Twa, Kirill V Larin
The mechanical properties of tissues can provide valuable information about tissue integrity and health and can assist in detecting and monitoring the progression of diseases such as keratoconus. Optical coherence elastography (OCE) is a rapidly emerging technique, which can assess localized mechanical contrast in tissues with micrometer spatial resolution. In this work we present a noncontact method of optical coherence elastography to evaluate the changes in the mechanical properties of the cornea after UV-induced collagen cross-linking...
May 2016: IEEE Journal of Selected Topics in Quantum Electronics
https://www.readbyqxmd.com/read/27503770/reducible-polyethylenimine-nanoparticles-for-efficient-sirna-delivery-in-corneal-neovascularization-therapy
#19
Hyounkoo Han, Sohee Son, Sejin Son, Namho Kim, Ji Young Yhee, Jae Hyeop Lee, Jun-Sub Choi, Choun-Ki Joo, Hohyeon Lee, Duhwan Lee, Won Jong Kim, Sun Hwa Kim, Ick Chan Kwon, Hyuncheol Kim, Kwangmeyung Kim
The aim of this study is to establish the safe and effective ocular delivery system of therapeutic small interfering RNA (siRNA) in corneal neovascularization therapy. The major hurdle present in siRNA-based corneal neovascularization (CNV) therapy is severe cytotoxicity caused by repetitive drug treatment. A reducible branched polyethylenimine (rBPEI)-based nanoparticle (NP) system is utilized as a new siRNA carrier as a hope for CNV therapy. The thiolated BPEI is readily self-crosslinked in mild conditions to make high molecular weight rBPEI thus allowing the creation of stable siRNA/rBPEI nanoparticles (siRNA-rBPEI-NPs)...
November 2016: Macromolecular Bioscience
https://www.readbyqxmd.com/read/27492108/effects-of-genipin-corneal-crosslinking-in%C3%A2-rabbit-corneas
#20
Marcel Y Avila, Mauricio Narvaez, Juan P Castañeda
PURPOSE: To evaluate the effect of genipin, a natural crosslinking agent, in rabbit eyes. SETTING: Department of Ophthalmology, Universidad Nacional de Colombia Centro de Tecnologia Oftalmica, Bogotá, Colombia. DESIGN: Experimental study. METHODS: Ex vivo rabbit eyes (16; 8 rabbits) were treated with genipin 1.00%, 0.50%, and 0.25% for 5 minutes with a vacuum device to increase corneal permeability. Penetration was evaluated using Scheimpflug pachymetry (Pentacam)...
July 2016: Journal of Cataract and Refractive Surgery
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