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Corneal crosslinking

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https://www.readbyqxmd.com/read/28532974/cost-effectiveness-analysis-of-corneal-collagen-crosslinking-for-progressive-keratoconus
#1
Daniel A Godefrooij, Marie-Josee J Mangen, Elsie Chan, David P S O'Brart, Saskia M Imhof, G Ardine de Wit, Robert P L Wisse
PURPOSE: To evaluate the cost effectiveness of corneal collagen crosslinking (CXL) for progressive keratoconus from the healthcare payer's perspective. DESIGN: A probabilistic Markov-type model using data from published clinical trials and cohort studies. PARTICIPANTS: Two identical cohorts, each comprising 1000 virtual patients with progressive bilateral keratoconus, were modeled; one cohort underwent CXL and the other cohort received no intervention...
May 19, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28532937/collagen-crosslinking-with-conventional-and-accelerated-ultraviolet-a-irradiation-using-riboflavin-with-hydroxypropyl-methylcellulose
#2
Anne Marie Hagem, Andreas Thorsrud, Gunhild Falleth Sandvik, Marianne Råen, Liv Drolsum
PURPOSE: To evaluate corneal collagen crosslinking (CXL) with conventional and accelerated ultraviolet-A (UVA) irradiation using riboflavin with methylcellulose. SETTING: Department of Ophthalmology, Oslo University Hospital, Oslo, Norway. DESIGN: Prospective randomized case series. METHODS: Patients with keratoconus were randomized to have CXL using conventional 3 mW/cm(2) UVA irradiation for 30 minutes (CXL30) or accelerated 9 mW/cm(2) UVA irradiation for 10 minutes (CXL10)...
April 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28523043/determining-the-efficacy-of-corneal-crosslinking-in-progressive-keratoconus
#3
Sidra Malik, Sadia Humayun, Shahzad Nayyar, Mazhar Ishaq
OBJECTIVE: To determine the Efficacy of Corneal Crosslinkage (CXL), using Corneal Topography, in eyes with progressive Keratoconus. METHODS: This randomized control trial was conducted at Armed Forces Institute of Ophthalmology, Rawalpindi, Pakistan from October 2013 to April 2014. A total of 60 eyes of 30 patients were included who presented with bilateral progressive Keratoconus. Each eye of the patient was randomized either to a treatment group (Group-A) or control untreated group (Group-B) of 30 eyes each...
March 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28513495/effect-of-post-crosslinking-haze-on-the-repeatability-of-scheimpflug-based-and-slit-scanning-imaging-devices
#4
Rohit Shetty, Aarti Agrawal, Rashmi Deshmukh, Luci Kaweri, Harsha L Rao, Harsha Nagaraja, Chaitra Jayadev
PURPOSE: The aim of this study was to analyze the effect of postcollagen crosslinking (CXL) haze on the measurement and repeatability of pachymetry and mean keratometry (Km) of four corneal topographers. MATERIALS AND METHODS: Sixty eyes of sixty patients with progressive keratoconus who had undergone accelerated CXL (ACXL) underwent imaging with a scanning slit imaging device (Orbscan II) and three Scheimpflug imaging devices (Pentacam HR, Sirius, and Galilei)...
April 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28495149/united-states-multicenter-clinical-trial-of-corneal-collagen-crosslinking-for-keratoconus-treatment
#5
Peter S Hersh, R Doyle Stulting, David Muller, Daniel S Durrie, Rajesh K Rajpal
PURPOSE: To evaluate the safety and efficacy of corneal collagen crosslinking (CXL) for the treatment of progressive keratoconus. DESIGN: Prospective, randomized, multicenter, controlled clinical trial. PARTICIPANTS: Patients with progressive keratoconus (n = 205). METHODS: The treatment group underwent standard CXL and the sham control group received riboflavin alone without removal of the epithelium. MAIN OUTCOME MEASURES: The primary efficacy criterion was the change over 1 year of topography-derived maximum keratometry value, comparing treatment with control group...
May 7, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28477073/-riboflavin-uva-crosslinking-in-progressive-keratoconus
#6
P Maier, T Reinhard
In patients with keratoconus, a progressive, ectatic disease of the cornea, the shape of the cornea is continuously changing leading to a reduction in visual acuity by progressive myopia and more and more (irregular) astigmatism. The symptomatic treatment consists of the prescription of glasses or special gas-permeable rigid contact lenses. Corneal tomography is generally used for diagnosis. After initial diagnosis of keratoconus, regular tomographic follow-ups should be performed. If clinically significant progression is found and confirmed by repeated measurements, riboflavin UVA collagen crosslinking should be offered to the patients...
May 5, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28470657/-morphologic-corneal-changes-after-crosslinking-for-keratoconus
#7
P L Müller, K U Löffler, M Kohlhaas, F G Holz, M C Herwig-Carl
Keratoconus is a relatively common (1 : 2000) bilateral disease leading to a change in biochemical and biomechanical corneal structure as well as thinning and ectasia. For more than 10 years, crosslinking has been a therapeutic option in cases of progression. Using riboflavin and UVA-radiation, the anterior corneal stroma (300 µm) gets stiffened by crosslinking of collagen fibers. When protocols and limitations are adhered, the procedure is described to be effective and of low-risk. This review gives an overview about physiologic and pathologic changes in keratoconic corneas before and after crosslinking...
May 3, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28461739/efficacy-of-transepithelial-corneal-collagen-crosslinking-for-keratoconus-12-month-follow-up
#8
Mohamed A Heikal, Tarek Tawfik Soliman, Ayser Fayed, Abdelmonem M Hamed
PURPOSE: To evaluate the efficacy of transepithelial corneal collagen crosslinking (TE-CXL) in patients with progressive keratoconus. PATIENTS AND METHODS: This is a prospective interventional consecutive study carried out on 30 eyes of 18 patients with progressive keratoconus who underwent TE-CLX using both ParaCel™ (riboflavin 0.25%, hydroxy propyl methyl cellulose, NaCl, ethylenediaminetetraacetic acid [EDTA], Tris, and benzalkonium chloride) and vibeX-Xtra (riboflavin 0...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28430702/re-tear-function-and-ocular-surface-alterations-after-accelerated-corneal-collagen-crosslinking-in-progressive-keratoconus
#9
Emine Kalkan Akcay, Betul Seher Uysal
No abstract text is available yet for this article.
May 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28430701/tear-function-and-ocular-surface-alterations-after-accelerated-corneal-collagen-crosslinking-in-progressive-keratoconus
#10
Zisis Gatzioufas, Mohamed Elalfy, Samer Hamada, Damian Lake
No abstract text is available yet for this article.
May 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28424993/performing-corneal-crosslinking-under-local-anaesthesia-in-patients-with-down-syndrome
#11
Nienke Soeters, Esmée Bennen, Robert P L Wisse
PURPOSE: To report on the ability to perform corneal crosslinking (CXL) under local anaesthesia for the treatment of keratoconus in patients with Down syndrome. METHODS: Nine eyes of seven patients with both keratoconus and Down syndrome were scheduled for an epithelium-off CXL procedure under local anaesthesia. Exclusion criteria were a corneal thickness under 400 µm and the presence of corneal scars. A standardized clinical decision tool was used to estimate patient cooperation and the likelihood for a successful procedure under local rather than general anaesthesia...
April 19, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28410728/corneal-collagen-crosslinking-and-pigment-dispersion-syndrome
#12
Benjamin R LaHood, Sacha Moore
We describe the case of a keratoconus patient with pigment dispersion syndrome (PDS) who was treated for progressive corneal ectasia with corneal collagen crosslinking (CXL). Pigment dispersion syndrome has been shown to have associated morphologic changes of the corneal endothelium. Corneal CXL has the potential to cause toxicity to the corneal endothelium, and adjacent pigment might increase the likelihood of damage. In this case, the presence of PDS had no detrimental effect on the outcome of treatment, and no complications were observed at 12 months follow-up, indicating that it may be safe to perform corneal CXL in the setting of PDS...
March 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28392939/thinner-corneas-appear-to-have-more-striking-effects-of-corneal-collagen-crosslinking-in-patients-with-progressive-keratoconus
#13
Yunfei Han, Yanyun Xu, Wei Zhu, Yuling Liu, Zhen Liu, Xiaoxiao Dou, Guoying Mu
Purpose. To analyze the outcomes and difference after UVA/riboflavin corneal collagen crosslinking (CXL) in four different corneal thickness groups of patients with progressive keratoconus. Methods. Retrospective study. Eyes with progressive keratoconus after CXL were divided into 4 subgroups as follows: group 1, thinnest corneal thickness (TCT) ≤ 400 µm; group 2, 400 µm < TCT ≤ 450 µm; group 3, 450 µm < TCT ≤ 500 µm; group 4, TCT ≥ 500 µm. Baseline, 6-month, and 12-month visual acuity, corneal topography, TCT, and endothelial cell density were evaluated...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28385234/hyaluronic-acid-and-beta-cyclodextrins-films-for-the-release-of-corneal-epithelial-cells-and-dexamethasone
#14
Calogero Fiorica, Fabio Salvatore Palumbo, Giovanna Pitarresi, Flavia Bongiovì, Gaetano Giammona
In this work we prepared hydrogels based on hyaluronic acid and β-cyclodextrins to sustain the release of both corneal epithelial cells and dexamethasone. This steroid is administered as eye drops several times per day to reduce the risk of rejection in the post operative period after the cornea transplantation and cell release techniques. Hydrogels were produced by crosslinking an amino derivative of hyaluronic acid, with the divinyl sulfone derivative of β-cyclodextrins, this last employed as a crosslinker and solubilizing agent...
June 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28384251/modeling-the-efficacy-profiles-of-uv-light-activated-corneal-collagen-crosslinking
#15
Jui-Teng Lin, Da-Chuan Cheng
OBJECTIVE: Analysis of the crosslink time, depth and efficacy profiles of UV-light-activated corneal collagen crosslinking (CXL). METHODS: A modeling system described by a coupled dynamic equations are numerically solved and analytic formulas are derived for the crosslinking time (T*) and crosslinking depth (z*). The z-dependence of the CXL efficacy is numerically produced to show the factors characterizing the profiles. RESULTS: Optimal crosslink depth (z*) and maximal CXL efficacy (Ceff) have opposite trend with respective to the UV light intensity and RF concentration, where z* is a decreasing function of the riboflavin concentration (C0)...
2017: PloS One
https://www.readbyqxmd.com/read/28379654/corneal-collagen-crosslinking-for-post-lasik-ectasia-an-australian-study
#16
Jessica Y Tong, Deepa Viswanathan, Christopher Hodge, Gerard Sutton, Colin Chan, John J Males
PURPOSE: Post laser-assisted in situ keratomileusis (LASIK) ectasia is a rare and unpredictable complication after LASIK. Corneal collagen crosslinking (CXL) has emerged as a promising technique to address this complication. Our study evaluates the long-term efficacy of CXL for post-LASIK ectasia in an Australian setting. DESIGN: Retrospective review of post-LASIK ectasia patients referred to and treated at 3 corneal refractive surgery institutions in Sydney, Australia...
March 29, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28376553/fungal-keratitis-a-six-year-review-at-a-tertiary-referral-centre
#17
K C Iselin, P B Baenninger, A Schmittinger-Zirm, M A Thiel, C Kaufmann
Background This review reports the epidemiology, laboratory results, treatment regimens and costs of fungal keratitis at a tertiary referral center in Lucerne, Switzerland. Patients and Methods Culture-proven fungal infections between January 2010 and December 2015 were reviewed retrospectively. Results Seventeen patients with a mean age of 52 years were identified. Contact lens wear was the most important risk factor (n = 11) (65 % of all cases), with filamentous fungi being identified as the most common fungus type (n = 10) (91 % of all cases of contact lens-associated fungal keratitis)...
April 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28366375/measuring-the-depth-of-crosslinking-demarcation-line-in%C3%A2-vivo-comparison-of-methods-and-devices
#18
Andreas Thorsrud, Gunhild F Sandvik, Anne M Hagem, Liv Drolsum
PURPOSE: To assess the interrelationship of different methods of measuring the demarcation line depth after corneal collagen crosslinking (CXL). SETTING: University eye clinic, Oslo, Norway. DESIGN: Prospective case series. METHODS: Eyes having CXL for progressive keratoconus were evaluated 1 month after CXL by in vitro confocal microscopy (IVCM), optical coherence tomography (OCT), and Scheimpflug imaging. When applying IVCM, the depth of the CXL demarcation line was measured with 2 methods; that is, IVCM keratocyte disappearance and IVCM intensity increase...
February 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28341606/safety-and-efficacy-of-sequential-intracorneal-ring-segment-implantation-and-crosslinking-in-pediatric-keratoconus
#19
Youssef Abdelmassih, Sylvain El-Khoury, Ali Dirani, Rafic Antonios, Ali Fadlallah, Carole G Cherfan, Elias Chelala, Elias F Jarade
PURPOSE: To evaluate the safety and visual outcome of intracorneal ring segment (ICRS) implantation followed by crosslinking in pediatric keratoconus patients. DESIGN: Retrospective interventional case series METHODS: This retrospective study included pediatric patients (≤14 years) with keratoconus and poor corrected distance visual acuity (CDVA) that underwent ICRS implantation and crosslinking (CXL). ICRS were inserted under topical anesthesia after creating a corneal tunnel with an Intralase femtosecond laser...
March 21, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28337057/accelerated-corneal-collagen-cross-linking-in-pediatric-keratoconus-one-year-study
#20
Amani E Badawi
PURPOSE: To evaluate the safety and effectiveness of accelerated corneal collagen crosslinking (CXL) in pediatric keratoconus. DESIGN: Prospective non-randomized observational study. METHODS: 33 eyes of 25 children with keratoconus were included. The corneal epithelium was mechanically removed. Next, riboflavin/hydroxypropyl methylcellulose solution) was applied for 10 min. Accelerated CXL (10 mW/cm(2) for 9 min), was accomplished. Visual acuity, slit lamp examination, refraction, keratometry readings, pachymetry, anterior and posterior elevations, average progression indices, and Q values were recorded...
January 2017: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
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