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Corneal crosslinking

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https://www.readbyqxmd.com/read/29778454/influence-of-the-beam-profile-crosslinking-setting-on-changes-in-corneal-topography-and-tomography-in-progressive-keratoconus-preliminary-results
#1
Robert Herber, Kathleen S Kunert, Věra Veliká, Eberhard Spoerl, Lutz E Pillunat, Frederik Raiskup
PURPOSE: To evaluate the effect of accelerated corneal crosslinking (CXL) with a "higher peripheral intensity" profile setting compared with a standard "top hat" profile setting performed using different CXL systems. SETTING: Department of Ophthalmology, University Hospital Carl Gustav Carus, Dresden, Germany. DESIGN: Retrospective case series. METHODS: Eyes from patients with progressive keratoconus were included...
May 16, 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29778107/photorefractive-intrastromal-corneal-crosslinking-for-treatment-of-myopic-refractive-error-findings-from-12-month-prospective-study-using-an-epithelium-off-protocol
#2
Matthias Elling, Inga Kersten-Gomez, H Burkhard Dick
PURPOSE: To assess the long-term effectiveness and safety of photorefractive intrastromal corneal crosslinking (CXL) in patients with low myopia. SETTING: Ruhr University Eye Hospital, Bochum, Germany. DESIGN: Prospective case series. METHODS: Healthy eyes with myopia were treated with photorefractive intrastromal CXL using the Mosaic System. Riboflavin 0.1% solution (VibeX Rapid) was topically administered, followed by 365 nm ultraviolet-A (30 mW/cm2 ) irradiance...
April 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29777678/uva-riboflavin-collagen-crosslinking-stiffening-effects-on-anterior-and-posterior-corneal-flaps
#3
Hamed Hatami-Marbini, Sandeep M Jayaram
The UVA/riboflavin collagen crosslinking (CXL) is one of the treatment procedure for stopping the progression of keratoconus. The inclusion criterion for this procedure is a minimum corneal thickness of 400 μm, which is not often met in patients with advanced keratoconus. Preoperatively swelling of thin corneas was shown to stabilize the keratectasia without any postoperative endothelial damage. Recently, we have shown that swelling porcine corneas prior to the CXL treatment had no significant effect on the resulting improvement in their tensile properties...
May 16, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29771883/-transepithelial-corneal-collagen-crosslinking-in-patients-with-progressive-keratoconus
#4
A I Kopaenko, N V Ivanova
PURPOSE: To assess the effectiveness of transepithelial collagen crosslinking (CXL) in patients with keratoconus. MATERIAL AND METHODS: The study involved 44 patients (44 eyes) with stage I-II progressive keratoconus. Patients were divided into two groups. The 1st group included 22 patients that had underwent transepithelial CXL. The 2nd group included 22 patients that had underwent traditional CXL. RESULTS AND DISCUSSION: All patients of the group 2 all patients had corneal syndrome, which lasted 2-4 days...
2018: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/29753555/evaluation-of-early-postoperative-ocular-pain-after-photorefractive-keratectomy-and-corneal-crosslinking
#5
Siamak Zarei-Ghanavati, Soheyla Jafarpour, Alireza Radyn-Majd, Hamed Hosseinikhah-Manshadi
PURPOSE: To evaluate and compare early postoperative pain after photorefractive keratectomy (PRK) and corneal crosslinking (CXL). SETTING: Khatam-al-Anbia Eye Hospital, Mashhad, Iran. DESIGN: Prospective case series. METHODS: The PRK group included patients with simple refractive errors whereas the CXL group included patients with clinical keratoconus. The groups were compared regarding the level of pain based on the visual analogue scale (VAS), verbal rating scale (VRS), and Wong-Baker FACES pain rating scale immediately after surgery, 6 hours postoperatively, and 1, 3, and 7 days postoperatively...
May 9, 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29750010/comparative-analysis-of-safety-and-efficacy-of-photorefractive-keratectomy-versus-photorefractive-keratectomy-combined-with-crosslinking
#6
Gitansha Shreyas Sachdev, Shreyas Ramamurthy, Ramamurthy Dandapani
Purpose: To assess the safety, efficacy, and refractive predictability of half-fluence accelerated corneal collagen crosslinking (CXL) applied concurrently with photorefractive keratectomy (PRK), and compare the results to standard PRK. Setting: Refractive Services, The Eye Foundation, Coimbatore, India. Design: Interventional comparative case series. Methods: Patients seeking refractive correction for myopia or myopic astigmatism were included in the study...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29709617/exploring-gelatin-nanoparticles-as-novel-nanocarriers-for-timolol-maleate-augmented-in-vivo-efficacy-and-safe-histological-profile
#7
Miral Shokry, Rania M Hathout, Samar Mansour
The use of gelatin has been gaining recognition in ocular delivery for its safety profile and biocompatible properties. Timolol Maleate (TM) is an anti-glaucoma drug possessing poor corneal penetration while causing eye irritation making it an ideal candidate for novel nanoparticulate systems. Timolol maleate loaded Gelatin Nanoparticles (GNPs) were prepared using the double desolvation method utilizing Glutaraldehyde as the crosslinking agent. Optimization of the nanoparticles was achieved through a full-factorial design...
April 27, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29703291/continuous-light-versus-pulsed-light-accelerated-corneal-crosslinking-with-ultraviolet-a-and-riboflavin
#8
Yirui Zhu, Peter S Reinach, Hanlei Zhu, Ling Li, Fan Yang, Jia Qu, Wei Chen
PURPOSE: To determine whether the pulsed-light ultraviolet-A (UVA) accelerated corneal crosslinking (CXL) procedure is more efficacious and selective than its continuous-light counterpart in rabbits. SETTING: School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China. DESIGN: Experimental study. METHODS: Fifty-four rabbits were divided into 2 groups. Group 1 had continuous-light accelerated CXL using 9 mW/cm2 UVA for 10 minutes (5...
March 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29703289/ability-of-a-new-crosslinked-polymer-ocular-bandage-gel-to-accelerate-reepithelialization-after-photorefractive-keratectomy
#9
Daniel S Durrie, Darcy Wolsey, Vance Thompson, Carol Assang, Brenda Mann, Barbara Wirostko
PURPOSE: To evaluate the safety and performance of a crosslinked thiolated carboxymethyl hyaluronic acid liquid-gel (CMHA-S) ocular bandage gel in accelerating reepithelialization of corneal defects created for photorefractive keratectomy (PRK). SETTING: Three community-based clinical research sites. DESIGN: Prospective case series. METHODS: Patients scheduled for bilateral PRK had both eyes randomized immediately after PRK to Group 1 (ocular bandage gel 4 times a day for 14 days and bandage contact lens), Group 2 (ocular bandage gel 4 times a day for 14 days), or Group 3 (control; bandage contact lens and artificial tears 4 times a day for 14 days)...
March 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29703286/transepithelial-corneal-crosslinking-for-keratoconus
#10
Peter S Hersh, Michael J Lai, John D Gelles, Sebastian P Lesniak
PURPOSE: To evaluate outcomes of corneal crosslinking (CXL) using a transepithelial technique for the treatment of keratoconus. SETTING: Cornea and refractive surgery subspecialty practice. DESIGN: Prospective case series. METHODS: Transepithelial CXL was performed in keratoconic eyes using riboflavin 0.1% and topical anesthetic containing benzalkonium chloride to facilitate riboflavin diffusion through the epithelium...
March 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29698993/evolution-of-keratoconus-from-diagnosis-to-therapeutics
#11
Lauren Marie Imbornoni, Charles Ninian John McGhee, Michael Wellington Belin
This review describes the evolution of the diagnosis and treatment of keratoconus from the earliest written description to present day. The first description was provided in 1736 by Benedict Duddell who described the prominent corneas of a fourteen-year-old boy. Throughout the 19th century, a variety of surgical procedures were proposed to manage the disease, such as surgically repositioning the pupil away from the cone, iris incarceration to produce a slit-like pupil, cauterization of the cone to produce a scar, and full thickness elliptical excision of the cone...
April 26, 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29685772/corneal-stromal-demarcation-line-after-4-protocols-of-corneal-crosslinking-in-keratoconus-determined-with-anterior-segment-optical-coherence-tomography
#12
Leopoldo Spadea, Lucia Di Genova, Emanuele Tonti
PURPOSE: To use anterior segment optical coherence tomography (AS-OCT) to compare corneal stromal demarcation line depth after 4 treatment protocols of corneal crosslinking (CXL). SETTING: Eye Clinic, Sapienza University of Rome, Terracina (Latina), Italy. DESIGN: Prospective case series. METHODS: Patients with progressive keratoconus were delegated to one of the following CXL treatments: (1) conventional epithelium (epi)-off 3 mW/cm2 according to the standard Dresden protocol (C-CXL group), (2) accelerated epi-off 10 mW/cm2 (A-CXL group), (3) transepithelial epi-on 3 mW/cm2 (TE-CXL group), or (4) transepithelial epi-on by iontophoresis 10 mW/cm2 (I-CXL group)...
April 20, 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29681834/amnwiotic-membrane-transplantation-as-a-treatment-for-sterile-infiltration-and-corneal-melting-after-corneal-crosslinking-for-keratoconus
#13
Takanori Sasaki, Takeshi Ide, Ikuko Toda, Naoko Kato
We report a case of corneal melting through sterile infiltration presumably due to excessive use of nonsteroidal anti-inflammatory eye drops after corneal crosslinking (CXL). It was treated using steroids combined with amniotic membrane transplantation (AMT). A 33-year-old man with progressing keratoconus underwent left eye CXL. We prescribed betamethasone and levofloxacin eye drops 5 times daily and diclofenac sodium eye drops 3 times daily for 3 days. Three days after CXL, there was a persistent epithelial defect and the left corneal stroma was clouded...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29673063/uv-light-crosslinking-regresses-mature-corneal-blood-and-lymphatic-vessels-and-promotes-subsequent-high-risk-corneal-transplant-survival
#14
Yanhong Hou, Viet Nhat Hung Le, Gábor Tóth, Sebastian Siebelmann, Jens Horstmann, Tim Gabriel, Felix Bock, Claus Cursiefen
Immunological graft rejection is the main complication after corneal transplantation into pathologically prevascularized so-called high risk eyes. Aim of this study was to evaluate whether UV-light crosslinking can regress pathological corneal blood and lymphatic vessels, and thereby improve subsequent graft survival. Using the murine model of suture-induced corneal neovascularization, we found that corneal crosslinking with ultraviolet (UV) A-light and riboflavin regressed both preexisting blood and lymphatic vessels significantly via inducing apoptosis in vascular endothelial cells...
April 19, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29666915/corneal-crosslinking-cxl-with-18-mw-cm-2-irradiance-and-5-4-j-cm-2-radiant-exposure-early-postoperative-safety
#15
Isaak Fischinger, Theo G Seiler, Karthiga Santhirasegaram, Moritz Pettenkofer, Chris P Lohmann, Daniel Zapp
PURPOSE: To investigate safety of accelerated corneal crosslinking during the first postoperative month. METHODS: In this retrospective study, 76 eyes of 60 patients with verified progressive keratectasia were enrolled in this study and followed for 1 month after accelerated CXL (18 mW/cm2 for 5 min, radiant exposure 5.4 J/cm2 ) (A-CXL(5*18)). Preoperatively, objective refraction, slit lamp inspection, and corneal tomography were performed. Early postoperative slit lamp examinations were performed on days 1 and 4...
April 17, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29623463/current-perspectives-on-corneal-collagen-crosslinking-cxl
#16
Sandeepani K Subasinghe, Kelechi C Ogbuehi, George J Dias
Corneal collagen crosslinking has revolutionized the treatment of keratoconus and post-refractive corneal ectasia in the past decade. Corneal crosslinking with riboflavin and ultraviolet A is proposed to halt the progression of keratectasia. In the original "Conventional Dresden Protocol" (C-CXL), the epithelium is removed prior to the crosslinking process to facilitate better absorption of riboflavin into the corneal stroma. Studies analyzing its short- and long-term outcomes revealed that although there are inconsistencies as to the effectiveness of this technique, the advantages prevail over the disadvantages...
April 6, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29610026/epithelial-remodeling-after-corneal-crosslinking-using-higher-fluence-and-accelerated-treatment-time
#17
Ilyse D Haberman, Paul Z Lang, Alvaro Fidalgo Broncano, Sang Woo Kim, Farhad Hafezi, J Bradley Randleman
PURPOSE: To evaluate changes in regional corneal epithelial thickness after corneal crosslinking (CXL) using higher fluence (7.2 J/cm2 ) and accelerated treatment time (4 minutes) in eyes with progressive keratoconus using spectral-domain optical coherence tomography (SD-OCT) and to correlate focal epithelial and focal anterior curvature changes. SETTING: Academic medical center in the United States. DESIGN: Prospective case series. METHODS: Patients had anterior segment SD-OCT (RTVue-100) with focal stromal and epithelial measurements and Scheimpflug imaging before and 1, 3, 6, and 12 months after accelerated CXL...
March 30, 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29605283/patient-satisfaction-with-epithelium-off-corneal-crosslinking
#18
Marianne O Price, Matthew T Feng, Francis W Price
PURPOSE: To assess patient satisfaction with corneal crosslinking (CXL). SETTING: Price Vision Group, Indianapolis, Indiana, USA. DESIGN: Prospective case series. METHODS: Patients treated with the Dresden protocol or accelerated epithelium-off CXL during an 8-year period were invited to participate in an electronic survey. RESULTS: Of the 552 patients who were invited to participate, 448 (80% response rate) completed the electronic survey...
March 28, 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29573222/concise-review-altered-versus-unaltered-amniotic-membrane-as-a-substrate-for-limbal-epithelial-cells
#19
REVIEW
Tor Paaske Utheim, Øygunn Aass Utheim, Panagiotis Salvanos, Catherine J Jackson, Stefan Schrader, Gerd Geerling, Amer Sehic
Limbal stem cell deficiency (LSCD) can result from a variety of corneal disorders, including chemical and thermal burns, infections, and autoimmune diseases. The symptoms of LSCD may include irritation, epiphora, blepharospasms, photophobia, pain, and decreased vision. There are a number of treatment options, ranging from nonsurgical treatments for mild LSCD to various forms of surgery that involve different cell types cultured on various substrates. Ex vivo expansion of limbal epithelial cells (LEC) involves the culture of LEC harvested either from the patient, a living relative, or a cadaver on a substrate in the laboratory...
March 23, 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29569838/the-feasibility-study-of-an-in-situ-marine-polysaccharide-based-hydrogel-as-the-vitreous-substitute
#20
Xiaolei Jiang, Yanfei Peng, Chaozhong Yang, Wanshun Liu, Baoqin Han
Although various biopolymers and synthetic compounds have been proposed and tested as the vitreous substitutes, no ideal material has been identified yet. In the present study, we developed an in situ-formed hydrogel by crosslinking hydroxypropyl chitosan with alginate dialdehyde. Physical properties of the hydrogel were studied and the cytotoxicity was evaluated using L929 fibroblasts, rabbit corneal endothelial cells and retinal pigment epithelial cells. In a preliminary in vivo study, the hydrogel was employed as vitreous substitute after vitrectomy surgery on rabbits and multiple parameters indicating biosafety and biocompatibility were measured and analyzed postoperatively...
March 23, 2018: Journal of Biomedical Materials Research. Part A
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