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https://www.readbyqxmd.com/read/28719486/p16-expression-and-biological-behavior-of-flat-vulvar-low-grade-squamous-intraepithelial-lesions-lsil
#1
Natasha Lewis, Luis Z Blanco, Kruti P Maniar
Flat low-grade squamous intraepithelial lesion (LSIL) of the vulva [vulvar intraepithelial neoplasia (VIN) 1, flat condyloma] is an uncommon entity with poorly understood biological behavior. We aimed to determine the risk of subsequent vulvar high-grade squamous intraepithelial lesion (HSIL) or carcinoma following a diagnosis of vulvar LSIL/VIN 1, as well as the frequency and predictive value of p16 immunohistochemical expression in this setting. Of the 51 included cases, p16 positivity (diffuse block staining) was identified in 2 (4%)...
November 30, 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28708790/trends-of-gynecological-cancers-in-turkey-towards-europe-or-asia
#2
Murat Gultekin, Irem Kucukyildiz, Mujdegul Zayifoglu Karaca, Selin Dundar, Guledal Boztas, Semra Hatice Turan, Ezgi Hacikamiloglu, Bekir Keskinkilic
OBJECTIVE: The aim of this study was to evaluate nationwide gynecological cancer trends in Turkey. METHODS: National cancer registry data (2009-2013) of Turkish Ministry of Health were evaluated. Ovarian, cervical, endometrial, vulvar, vaginal, and tubal cancers are evaluated with respect to age of diagnosis, incidence rates within years, stage, histological distributions, and mortality rates. Data were collected from active cancer registry centers, which increased from 23% in 2009 to 47...
July 13, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28706405/vulvar-lichen-sclerosus-et-atrophicus
#3
REVIEW
Pragya Ashok Nair
Vulvar lichen sclerosus (VLS) is a chronic inflammatory dermatosis characterized by ivory-white plaques or patches with glistening surface commonly affecting the vulva and anus. Common symptoms are irritation, soreness, dyspareunia, dysuria, and urinary or fecal incontinence. Anogenital lichen sclerosus (LS) is characterized by porcelain-white atrophic plaques, which may become confluent extending around the vulval and perianal skin in a figure of eight configuration. Thinning and shrinkage of the genital area make coitus, urination, and defecation painful...
April 2017: Journal of Mid-life Health
https://www.readbyqxmd.com/read/28700423/sox2-gene-amplification-and-overexpression-is-linked-to-hpv-positive-vulvar-carcinomas
#4
André Gut, Holger Moch, Matthias Choschzick
SOX2 (SRY-related HMG-box 2) belongs to the SOX gene family of high-mobility transcription factors indispensably involved in gene regulation in pluripotent stem cells and neural differentiation. SOX2 copy number increases have been frequently reported in various types of squamous cell cancer. To better understand the effect of SOX2 aberrations on vulvar cancer phenotype and patient prognosis, we analyzed SOX2 copy number changes using fluorescence in situ hybridization and SOX2 expression by immunohistochemistry in 55 squamous cell carcinomas of the vulva...
July 11, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28687171/volume-controlled-versus-short-drainage-after-inguinofemoral-lymphadenectomy-in-vulvar-cancer-patients-a-dutch-nationwide-prospective-study
#5
A W Pouwer, F Hinten, J van der Velden, R G V Smolders, B F M Slangen, H J M A A Zijlmans, J IntHout, A G J van der Zee, D Boll, K N Gaarenstroom, H J Arts, J A de Hullu
OBJECTIVE: Inguinofemoral lymphadenectomy for patients with vulvar squamous cell carcinoma is associated with a high incidence of postoperative wound complications, which may be influenced by inguinal drain management. The aim of this nationwide prospective study (MAMBO: Morbidity And Measurement of the BOdy) was to assess the feasibility and the incidence of complications after volume-controlled versus short drainage. METHODS: The MAMBO study consisted of two observational studies in all eight oncology centers in the Netherlands, conducted between 2012 and 2016...
July 4, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28667573/urologic-dermatology-a-review
#6
REVIEW
Andrew W Stamm, Kathleen C Kobashi, Ksenija B Stefanovic
PURPOSE OF REVIEW: Genital dermatology represents a challenge to many providers. Though dermatologic lesions involving the genitalia may present to any of a number of practices, ranging from primary care to urology, gynecology, and dermatology, few training programs provide significant training regarding the diagnosis and management of genital dermatologic lesions. The purpose of this review is to provide urologists with an overview of common genital dermatological lesions that may be encountered in a clinic...
August 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28664179/the-tell-tale-heart-a-case-of-recurrent-vulvar-carcinoma-with-cardiac-metastasis-and-review-of-literature
#7
Syed Imran Mustafa Jafri, Naveed Ali, Salman Farhat, Faizan Malik, Mark Shahin
A 50-year-old female was diagnosed with vulvar cancer treated with left partial vulvectomy and bilateral lymphadenectomy. Ten months after her surgery, she presented with increased labial swelling, pain and discharge. Biopsy confirmed recurrence of squamous cell vulvar carcinoma. Incidentally, on restaging radiographic scans, she was found to have a large right ventricular mass which, after surgical debulking, was shown to be a squamous cell cancer of vulvar origin. She was commenced on chemotherapy with carboplatin and paclitaxel along with concurrent radiation therapy...
August 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28662775/improved-survival-with-definitive-chemoradiation-compared-to-definitive-radiation-alone-in-squamous-cell-carcinoma-of-the-vulva-a-review-of-the-national-cancer-database
#8
Yuan James Rao, Re-I Chin, Caressa Hui, David G Mutch, Matthew A Powell, Julie K Schwarz, Perry W Grigsby, Stephanie Markovina
BACKGROUND: It is unclear whether definitive chemoradiation (CRT) results in improved overall survival compared to radiation therapy (RT) alone in patients with vulvar cancer who are not candidates for surgery. We compared these treatment strategies in the National Cancer Database (NCDB). METHODS: We identified 1352 patients with pathologically-confirmed squamous cell carcinoma of the vulva treated with definitive RT (n=353) or definitive CRT (n=999) between 2003 and 2014 in the NCDB...
June 27, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28657384/cutaneous-metastasis-from-vulvar-squamous-cell-carcinoma-a-rare-occurrence-that-should-not-be-forgotten
#9
Nicolò Bizzarri, Valerio Gaetano Vellone, Luca Parodi, Luana Calanni Fraccono, Valentina Ghirardi, Sergio Costantini, Mario Valenzano Menada, Paolo Sala
Vulvar cancer accounts for 5% of the female genital tract cancers. Cutaneous metastases from vulvar cancer are extremely rare and for this reason, it can be difficult to reach a diagnosis with a consequent delay in the treatment. A systematic literature review of articles on this subject was conducted through a MEDLINE-based search for articles published in English or French. To date, 16 cases (including ours unpublished) of cutaneous metastasis from vulvar cancer have been reported. Cutaneous metastasis can occur from any stage of vulvar cancer, even after a short period...
June 28, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28644191/yield-of-cytology-surveillance-after-high-grade-vulvar-intraepithelial-neoplasia-or-cancer
#10
Lindsay M Kuroki, Antonina I Frolova, Ningying Wu, Jingxia Liu, Matthew Powell, Premal H Thaker, L Stewart Massad
OBJECTIVES: The aim of the study was to estimate the risk of high-grade cervical and vaginal intraepithelial neoplasia (CIN/VAIN 2+) and cancer among women treated surgically for high-grade vulvar intraepithelial neoplasia (HGVIN) and vulvar cancer. MATERIALS AND METHODS: We performed a retrospective cohort study of women who underwent surgery for HGVIN/vulvar cancer between 2006 and 2010. Univariate and multivariate analyses using stepwise selection were used to identify correlates of abnormal cytology after treatment for VIN and vulvar cancer...
July 2017: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/28638271/proex-c-as-diagnostic-marker-for-detection-of-urothelial-carcinoma-in-urinary-samples-a-review
#11
REVIEW
Gerardo Botti, Maria Gabriella Malzone, Elvira La Mantia, Micaela Montanari, Daniela Vanacore, Sabrina Rossetti, Vincenzo Quagliariello, Carla Cavaliere, Rossella Di Franco, Luigi Castaldo, Gianluca Ametrano, Francesca Cappuccio, Francesco Jacopo Romano, Raffaele Piscitelli, Maria Filomena Pepe, Carmine D'Aniello, Gaetano Facchini
The gold standard for the detection of urothelial carcinoma is represented by urethro-cystoscopy and biopsy. Both procedures are invasive and expensive and therefore cytology is often used as first approach to investigate on a possible neoplasia, being a safe and cost-effective diagnostic modality of evaluation. Because cytology alone is not highly sensitive for detection of low grade urothelial carcinoma and recurrence of the disease, several adjunct markers and urine based tests for urothelial carcinoma have been developed, which can help in the final diagnosis...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28602173/clinical-significance-and-prognostic-value-of-femoral-lymph-node-metastasis-in-figo-stage-iii-vulvar-carcinoma
#12
H Tu, P Sun, H F Gu, X K Zhang, H Huang, T Wan, J H Liu
OBJECTIVES: To determine the clinical significance and prognostic value of femoral lymph node metastasis (FLNM) in patients with International Federation of Gynecology and Obstetrics (FIGO) stage III vulvar carcinoma. METHODS: The medical records of patients with vulvar carcinoma who underwent inguinofemoral lymphadenectomy between 1990 and 2013 were retrospectively reviewed. RESULTS: Of 66 patients with stage III vulvar carcinoma, 42 had superficial lymph node metastasis (SLNM) only and 24 had FLNM...
May 31, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28590952/role-of-human-papillomavirus-in-vulvar-cancer
#13
Natalia Rakislova, Adela Saco, Adriana Sierra, Marta Del Pino, Jaume Ordi
Human papillomavirus (HPV) is involved in one of the at least 2 pathways leading to vulvar squamous cell carcinoma (VSCC). Inactivation of p53 and retinoblastoma by the viral products E6 and E7 is involved in malignant transformation. The percentage of HPV-positive VSCCs ranges from 18% to 75%, depending on the geographical area. HPV-associated tumors affect relatively young women and arise from high-grade intraepithelial lesions, identical to other HPV-associated premalignant lesions of the anogenital tract...
July 2017: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/28577297/prevalence-and-type-distribution-of-human-papillomavirus-in-squamous-cell-carcinoma-and-intraepithelial-neoplasia-of-the-vulva
#14
Mette T Faber, Freja L Sand, Vanna Albieri, Bodil Norrild, Susanne K Kjaer, Freija Verdoodt
In this updated systematic review and meta-analysis, we estimate the pooled prevalence of human papillomavirus (HPV) DNA and HPV type distribution in squamous cell carcinoma of the vulva (vulvar cancer) and vulvar intraepithelial neoplasia (VIN). PubMed, Embase and Cochrane Library databases were used to identify studies published between 1990 and 2015 and using a PCR-based or hybrid capture test to evaluate the presence of HPV DNA in vulvar cancer or VIN. Pooled estimates of the HPV prevalence with corresponding 95% confidence intervals (CI) were calculated based on a random effects model...
June 2, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28574130/hpv-related-vulvar-diseases-and-perspectives-of-p16ink4a-immunochemistry-a-review-of-the-literature
#15
Angela Carrone, Lucia Riganelli, Delia Savone, Assunta Casorelli, Lucia Merlino, Francesco Pecorini, Irene Pecorella, Pasquale Mancino, Maria Grazia Piccioni, Pierluigi Benedetti Panici
INTRODUCTION: Two different types of vulvar intraepithelial neoplasia (VIN), HPV-related and HPV-unrelated, should be considered as two separate entities with different management options. The incidence of HPV-related VIN is increasing worldwide and is implicated in carcinogenesis. Our objective is to investigate the use of p16INK4a immunostaining or p16INK4a/p53 double staining for the detection of HPV-related disease to overcome the problem that histological criteria often have significant overlap...
May 26, 2017: Tumori
https://www.readbyqxmd.com/read/28565920/vulvar-basal-cell-carcinoma-four-case-reports-with-immunohistochemical-study
#16
Mª Reyes García-de-la-Fuente, Maria Santacana, Felip Vilardell, R M Pujol, Eloi Gari, J M Casanova
Basal cell carcinomas (BCC) are the most frequent tumours in humans and normally appear in photoexposed areas of the skin. It is widely accepted that BCCs originate at follicular stem cells and consequently are very rare in nonhairy areas. Here, we report 4 cases of vulvar BCC, 3 of which were located in a vulvar semimucous area, a nonphotoexposed area, and a nonhairy area. We have determined the CK7 and CK19 profile of all cases; both are markers of simple epithelium with glandular differentiation. Interestingly, all cases were positively stained for CK7 and CK19...
May 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28556593/comparative-molecular-profiling-of-hpv-induced-squamous-cell-carcinomas
#17
Robert F Koncar, Rebecca Feldman, El Mustapha Bahassi, Nooshin Hashemi Sadraei
Approximately 5% of all cancer incidences result from human papillomavirus (HPV) infection. HPV infection most commonly leads to cancers of the anogenital region or oropharynx. It is unknown whether different HPV-mediated cancers collectively share a molecular signature and it is important to determine if there are targetable alterations common to different types of HPV-positive tumors. We analyzed 743 p53 wild-type samples of anal, cervical, oropharyngeal, and vulvar squamous cell carcinomas which underwent multiplatform testing at a commercial molecular profiling service...
July 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28551895/-sentinel-lymph-nodes-dissection-in-gynecological-malignancies
#18
REVIEW
Yael Naaman, Limor Goldenhersh, Alon Ben-Arie
During the last decade sentinel lymph nodes biopsy has become an essential part of primary surgical treatment in a number of malignancies including breast cancer, melanoma and head-and-neck malignancies. Dye or radioactive substances are injected at the primary tumor site, followed by pre-operative and intra-operative mapping. During surgery only positive lymph nodes are being dissected instead of a complete dissection of the lymphatic basin. The advantages of sentinel lymph nodes dissection are reducing the side effects of extensive lymph nodes dissection, while maintaining high detection rates and sensitivity in identifying cases with lymphatic tumor spread...
February 2017: Harefuah
https://www.readbyqxmd.com/read/28541790/long-lasting-increased-risk-of-human-papillomavirus-related-carcinomas-and-premalignancies-after-cervical-intraepithelial-neoplasia-grade-3-a-population-based-cohort-study
#19
Renée M F Ebisch, Dominiek W E Rutten, Joanna IntHout, Willem J G Melchers, Leon F A G Massuger, Johan Bulten, Ruud L M Bekkers, Albert G Siebers
Purpose The aim of this study was to determine the risk of human papillomavirus (HPV)-related carcinomas and premalignancies in women diagnosed with cervical intraepithelial neoplasia grade 3 (CIN3). Knowledge of this risk is important to preventing the development and progression of other HPV-related premalignancies and carcinomas, by considering prophylactic HPV vaccination and/or by paying increased attention to other HPV-related carcinomas and premalignancies when CIN3 is identified. Methods Women diagnosed with a CIN3 between 1990 and 2010 were identified from the Dutch nationwide registry of histopathology and cytopathology (PALGA) and matched with a control group of women without CIN3...
May 25, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28541626/risk-factors-for-unrecognized-invasive-carcinoma-in-patients-with-vulvar-high-grade-squamous-intraepithelial-lesion-at-vulvoscopy-directed-biopsy
#20
Mario Preti, Lauro Bucchi, Bruno Ghiringhello, Silvana Privitera, Valentina Frau, Elisabetta Corvetto, Chiara Benedetto, Leonardo Micheletti
OBJECTIVE: To evaluate the prevalence and risk factors for unrecognized invasive carcinoma in a series of patients undergoing surgical excision after an office biopsy of vulvar high-grade squamous intraepithelial lesion (VHSIL). METHODS: Two hundred and sixteen consecutive patients treated in a tertiary-level referral center for vulvar disease in north-western Italy were recruited. Patients' records were reviewed by trained personnel. Factors showing a statistically significant (p<0...
July 2017: Journal of Gynecologic Oncology
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