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Vulvar carcinoma

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https://www.readbyqxmd.com/read/27900089/pregnancy-and-cesarean-delivery-after-multimodal-therapy-for-vulvar-carcinoma-a-case-report
#1
Kuniaki Toriyabe, Haruki Taniguchi, Tokihiro Senda, Masako Nakano, Yoshinari Kobayashi, Miho Izawa, Hirohiko Tanaka, Tetsuo Asakura, Tsutomu Tabata, Tomoaki Ikeda
Reports of pregnancy following treatment for vulvar carcinoma are extremely uncommon, as the main problem of subsequent pregnancy is vulvar scarring following radical surgery. We herein report the case of a patient who was diagnosed with stage I squamous cell carcinoma of the vulva at the age of 17 years and was treated with multimodal therapy, including neoadjuvant chemotherapy, wide local excision with bilateral inguinal lymph node dissection and adjuvant radiotherapy. The patient became pregnant spontaneously 9 years after her initial diagnosis and the antenatal course was good, except for mild acute pyelonephritis at 25 weeks of gestation...
November 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27896230/evaluation-of-symptoms-and-prevention-of-cancer-in-menopause-the-value-of-vulvar-exam
#2
A R Palumbo, C Fasolino, G Santoro, V Gargano, M Rinaldi, B Arduino, M Belli, M Guida
Vulvar and vaginal atrophy (VVA), is a chronic medical condition experienced by postmenopausal women, with prevalence estimated ranging from 10% to 50% [1]. VVA is characterized by a constellation of symptoms, that may affect daily activities, sexuality, relationships, and quality of life [3]. Early recognition and effective treatment of VVA may enhance sexual health and the quality of life of women and their partners. Some vulvar conditions such as lichen sclerosus are more prevalent in the postmenopausal years...
November 2016: Translational Medicine @ UniSa
https://www.readbyqxmd.com/read/27872535/femoral-arterial-blowout-post-groin-recurrence-in-vulvar-carcinoma-novel-endovascular-management
#3
Pallipuram Seshadrinathan Bhageerathy, Anitha Thomas, Vinotha Thomas, Shyamkumar N Keshava, Abraham Peedicayil
No abstract text is available yet for this article.
December 2016: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27870709/groin-recurrences-in-node-negative-vulvar-cancer-patients-after-sole-sentinel-lymph-node-dissection
#4
Rüdiger Klapdor, Hermann Hertel, Philipp Soergel, Peter Hillemanns
OBJECTIVE: This study aimed to evaluate the recurrence rates after sole sentinel dissection in vulvar cancer and describe characteristics of groin recurrences. METHODS: All vulvar cancer cases between 2008 and 2014 were reviewed. Inclusion criteria were restricted to lymph node-negative patients, sole sentinel lymph node dissection (SLND), and tumor diameter less than 4 cm. In all patients, Tc-99m nanocolloid was used for preoperative SLN imaging. Regularly, planar lymphoscintigraphy and single-photon emission computed tomography with computed tomography were performed...
November 17, 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27865454/does-a-groin-node-dissection-in-vulvar-cancer-affect-groin-recurrence-and-overall-survival-results-from-a-population-based-cohort-study
#5
Lilian T Gien, Rinku Sutradhar, Gillian Thomas, Allan Covens, Laurie Elit, Eileen Rakovitch, Anthony Fyles, Mahmoud A Khalifa, Ying Liu, Lisa Barbera
BACKGROUND: To determine, in a population-based cohort of vulvar cancer patients, if groin node dissection (GND) decreases the risk of groin recurrence and increases overall survival. METHODS: This population-based retrospective cohort study includes all cases of invasive squamous cell carcinoma identified in a provincial cancer registry from 1998 to 2007. Data collection was completed for all clinical and pathologic factors by chart abstraction. Cumulative incidence functions for recurrence were estimated, accounting for death before recurrence as a competing risk...
November 16, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27844049/sebaceous-carcinoma-of-the-vulva-a-case-report-and-review-of-the-literature
#6
Stephanie A Sullivan, Arthur-Quan Tran, Siobhan O'Connor, Paola A Gehrig
•Sebaceous carcinoma (SC) is rare with only nine cases reported in the literature.•Extraocular SC likely has similar prognosis to ocular SC.•Reporting of vulvar SC should include detailed pathologic information so that risk factor associations can be made.
November 2016: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/27843030/adjuvant-radiation-therapy-for-margin-positive-vulvar-squamous-cell-carcinoma-defining-the-ideal-dose-response-using-the-national-cancer-data-base
#7
Bhavana V Chapman, Beant S Gill, Akila N Viswanathan, Goundappa K Balasubramani, Paniti Sukumvanich, Sushil Beriwal
PURPOSE: Positive surgical margins after radical vulvectomy for vulvar cancer portend a high risk for local relapse, which may be challenging to salvage. We assessed the impact of adjuvant radiation therapy (aRT) on overall survival (OS) and the dose-response relationship using the National Cancer Data Base. METHODS AND MATERIALS: Patients with vulvar squamous cell carcinoma who underwent initial extirpative surgery with positive margins from 1998 to 2012 were included...
September 24, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27836203/patient-treatment-and-discharge-factors-associated-with-hospital-readmission-within-30days-after-surgery-for-vulvar-cancer
#8
K M Dorney, W B Growdon, J Clemmer, J A Rauh-Hain, T R Hall, E Diver, D Boruta, M G Del Carmen, A Goodman, J O Schorge, N Horowitz, R M Clark
OBJECTIVES: The majority of hospital readmissions are unexpected and considered adverse events. The goal of this study was to examine the factors associated with unplanned readmission after surgery for vulvar cancer. METHODS: Patient demographic, treatment, and discharge factors were collected on 363 patients with squamous cell carcinoma in situ or invasive cancer who underwent vulvectomy at our institution between January 2001 and June 2014. Clinical variables were correlated using χ(2) test and Student's t-test as appropriate for univariate analysis...
November 8, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27834349/differentiated-exophytic-vulvar-intraepithelial-lesions-are-genetically-distinct-from-keratinizing-squamous-cell-carcinomas-and-contain-mutations-in-pik3ca
#9
Jaclyn C Watkins, Brooke E Howitt, Neil S Horowitz, Lauren L Ritterhouse, Fei Dong, Laura E MacConaill, Elizabeth Garcia, Neal I Lindeman, Larissa J Lee, Ross S Berkowitz, Marisa R Nucci, Christopher P Crum
Human papillomavirus-negative keratinizing vulvar cancers typically harbor TP53 mutations as do their precursors, differentiated vulvar intraepithelial neoplasia. However, atypical verruciform proliferations are also associated with these malignancies and their pathogenesis is poorly understood. This study compared 11 atypical verruciform lesions, including atypical verruciform hyperplasia, vulvar acanthosis with altered differentiation, and verruciform lichen simplex chronicus, with 14 human papillomavirus-negative keratinizing squamous cell carcinomas...
November 11, 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27832810/eccrine-porocarcinoma-of-the-vulva-a-case-report-and-review-of-the-literature
#10
Ayako Fujimine-Sato, Masafumi Toyoshima, Shogo Shigeta, Asami Toki, Takashi Kuno, Izumi Sato, Mika Watanabe, Hitoshi Niikura, Nobuo Yaegashi
BACKGROUND: Malignant tumors arising from the vulva account for only 0.6 % of all cancers in female patients. The predominant histologic type, representing about 90 % of these malignancies, is squamous cell carcinoma. Eccrine porocarcinoma is a rare malignant tumor arising from sweat glands. The incidence of eccrine porocarcinoma is estimated at 0.005-0.01 % of all cutaneous tumors. To the best of our knowledge, only seven previous cases of vulvar eccrine porocarcinoma have been reported in the English-language literature...
November 10, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27832422/radiation-induced-lichen-sclerosus-of-the-vulva-first-report-in-the-medical-literature
#11
Lisa R Edwards, Emily D Privette, James W Patterson, Georgi Tchernev, Anastasiya Atanasova Chokoeva, Uwe Wollina, Torello Lotti, Barbara B Wilson
A 67-year-old woman presented with a firm plaque in the perineal region, 16 months after diagnosis of a high-grade basaloid squamous cell carcinoma of the vagina and treatment by external beam radiation therapy and vaginal cuff brachytherapy. The differential diagnosis included radiation-induced morphea, radiation dermatitis, or, possibly, radiation-induced lichen sclerosus. Biopsy findings, including special staining, confirmed the diagnosis of radiation-induced lichen sclerosus. To our knowledge, this is the first report of radiation-induced lichen sclerosus of the vulvar region...
November 10, 2016: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/27801760/the-prevalence-of-lichen-sclerosus-in-patients-with-vulvar-squamous-cell-carcinoma
#12
Jonathan J Davick, Megan Samuelson, James T Krone, Colleen K Stockdale
Women with vulvar lichen sclerosus (LS) have an increased risk of developing differentiated vulvar intraepithelial neoplasia and vulvar squamous cell carcinoma (SCC). Our primary aim was to determine the prevalence of LS among women with vulvar SCC. All patients who underwent excision for invasive SCC of the vulva from January 1, 2009 to December 31, 2013 were identified by searching our institution's electronic laboratory information system (n=111). The vulvar excision specimens from these patients were reviewed for the presence of adjacent LS...
October 31, 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/27763794/evaluation-of-the-vulvar-cancer-histology-code-reported-by-central-cancer-registries-importance-in-epidemiology
#13
David A Siegel, Reda Wilson, Edward J Wilkinson, Julia W Gargano, Meg Watson, Brenda Y Hernandez, Marc T Goodman, Charles F Lynch, Elizabeth R Unger, Mona Saraiya
CONTEXT: -Knowing the subtype of vulvar cancer histology is important for estimating human papillomavirus-related cancer etiology. Surveillance of human papillomavirus-related vulvar cancers informs public health decisions related to vaccination against human papillomavirus. OBJECTIVE: -To assess the accuracy of registry classifications of vulvar cancer and determine the histologic classification of cases reported as not otherwise specified. DESIGN: -Pathology specimens were collected from Florida, Iowa, and Hawaii cancer registries...
October 20, 2016: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/27755170/vulvar-perianal-and-perineal-cancer-after-hidradenitis-suppurativa-a-systematic-review-and-pooled-analysis
#14
Georgios-Marios Makris, Nikiforita Poulakaki, Aristea-Maria Papanota, Evgenia Kotsifa, Theodoros N Sergentanis, Theodora Psaltopoulou
BACKGROUND: Hidradenitis suppurativa (HS) is a chronic inflammatory disease that frequently involves the perineal and perianal regions. The association between HS and malignant transformation is a rare but under recognized phenomenon. OBJECTIVE: This systematic review aims to summarize all available cases of vulvar and perianal/perineal cancer emerging in patients with HS, describing clinical and therapeutic particularities of these coexisting conditions in female patients...
October 13, 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/27752532/metastastic-vulvar-squamous-cell-carcinoma-mimicking-genital-herpes
#15
Jennifer D Bahner, Jeffrey F Scott, Pezhman Shoureshi, Kord Honda, Meg R Gerstenblith
No abstract text is available yet for this article.
September 2016: JAAD Case Reports
https://www.readbyqxmd.com/read/27741038/microcystic-adnexal-vulvar-carcinoma-a-case-report
#16
Claudia Marchitelli, Maria Sol Peremateu, Desiree Pasetti, Maria Celeste Sluga, Alejandra Wernicke, Sebastian Gogorza
No abstract text is available yet for this article.
October 12, 2016: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/27714462/preoperative-elevated-platelet-count-and-thrombocytosis-in-gynecologic-malignancies
#17
Joseph Menczer
PURPOSE: Platelets have multiple functions and they also play an important role in malignancies. Elevated platelet count and thrombocytosis at the time of diagnosis in patients with many solid tumors correlates with prognosis and is associated with poor survival. The aim of the following report is to review the literature concerning elevated platelet count and thrombocytosis in gynecologic malignancies. METHOD: A PubMed search of all English literature peer-reviewed publications was performed containing the terms elevated platelet count or thrombocytosis and vulvar cancer, cervical cancer, endometrial cancer, and ovarian cancer...
October 6, 2016: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/27675945/implication-of-adjuvant-radiation-therapy-and-dose-response-relationship-for-margin-positive-vulvar-squamous-cell-carcinoma
#18
B S Gill, A N Viswanathan, G K Balasubramani, P Sukumvanich, S Beriwal
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27674298/intensity-modulated-radiation-therapy-for-vulvar-carcinoma-changes-in-practice-over-5-years
#19
M Barkati, B King, I Fortin, L Portelance, A N Viswanathan, T W Fyles, S Beriwal, J Alfieri, K S Lim, M M Harkenrider, W Small, A H Klopp, A Stewart, C M Yashar, W R Bosch, A Jhingran, M Jolicoeur, D K Gaffney
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27674281/anatomic-distribution-of-inguinal-lymph-nodes-in-patients-with-vulvar-carcinoma
#20
J R Gunther, J Yang, P Bhosale, R T Williamson, A H Klopp, A Jhingran, P J Eifel
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
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