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Vulvar carcinoma

Jennifer D Bahner, Jeffrey F Scott, Pezhman Shoureshi, Kord Honda, Meg R Gerstenblith
No abstract text is available yet for this article.
September 2016: JAAD Case Reports
Claudia Marchitelli, Maria Sol Peremateu, Desiree Pasetti, Maria Celeste Sluga, Alejandra Wernicke, Sebastian Gogorza
No abstract text is available yet for this article.
October 12, 2016: Journal of Lower Genital Tract Disease
Joseph Menczer
PURPOSE: Platelets have multiple functions and they also play an important role in malignancies. Elevated platelet count and thrombocytosis at the time of diagnosis in patients with many solid tumors correlates with prognosis and is associated with poor survival. The aim of the following report is to review the literature concerning elevated platelet count and thrombocytosis in gynecologic malignancies. METHOD: A PubMed search of all English literature peer-reviewed publications was performed containing the terms elevated platelet count or thrombocytosis and vulvar cancer, cervical cancer, endometrial cancer, and ovarian cancer...
October 6, 2016: Archives of Gynecology and Obstetrics
B S Gill, A N Viswanathan, G K Balasubramani, P Sukumvanich, S Beriwal
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
M Barkati, B King, I Fortin, L Portelance, A N Viswanathan, T W Fyles, S Beriwal, J Alfieri, K S Lim, M M Harkenrider, W Small, A H Klopp, A Stewart, C M Yashar, W R Bosch, A Jhingran, M Jolicoeur, D K Gaffney
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
J R Gunther, J Yang, P Bhosale, R T Williamson, A H Klopp, A Jhingran, P J Eifel
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Kohei Aoyama, Hiroshi Matsushima, Morio Sawada, Taisuke Mori, Satoru Yasukawa, Jo Kitawaki
Primary vulvar adenocarcinomas are very rare. We describe the rare case of primary vulvar apocrine adenocarcinoma, a histologically rare subtype of vulvar adenocarcinoma. A 57-year-old Japanese woman presented with an enlarging vulvar mass. A dark-red, hemorrhagic, ulcerated tumor was on the right side of the anterior labial commissure measuring approximately 3.5 × 3.5 cm. Preoperative biopsy showed poorly differentiated carcinoma with partial differentiation to adenocarcinoma. Systemic examination revealed lymph node metastases in both inguinal regions and no other primary source...
2016: Case Reports in Obstetrics and Gynecology
Deyin Xing, Salwa Bakhsh, Nataliya Melnyk, Christina Isacson, Julie Ho, David G Huntsman, C Blake Gilks, Brigitte M Ronnett, Hugo M Horlings
Adenoid cystic carcinoma is a rare malignant tumor that usually arises in the major and minor salivary glands and other locations containing secretory glands, including the lower female genital tract. Lower female genital tract carcinomas with adenoid cystic differentiation can be subclassified into 2 distinct groups based on the presence or absence of high-risk HPV. Cervical mixed carcinomas with some adenoid cystic differentiation are high-risk HPV-related but pure adenoid cystic carcinomas of vulvar and cervical origin appear to be unrelated to high-risk HPV...
September 22, 2016: International Journal of Gynecological Pathology
L S Nooij, F A M Brand, K N Gaarenstroom, C L Creutzberg, J A de Hullu, M I E van Poelgeest
Recurrent disease occurs in 12-37% of patients with vulvar squamous cell carcinoma (VSCC). Decisions about treatment of recurrent VSCC mainly depend on the location of the recurrence and previous treatment, resulting in individualized and consensus-based approaches. Most recurrences (40-80%) occur within 2 years after initial treatment. Currently, wide local excision is the treatment of choice for local recurrences. Isolated local recurrence of VSCC has a good prognosis, with reported 5-year survival rates of up to 60%...
October 2016: Critical Reviews in Oncology/hematology
Sha Ni, Xiaoyu Zhao, Ling Ouyang
Researchers have recently demonstrated the key role of long non-coding RNAs (lncRNAs) in regulating embryogenesis and gene expression. However, the exact mechanism used by lncRNAs in carcinogenesis is still unclear. In particular, studies regarding the role of lncRNAs in vulvar squamous cell carcinomas (VSCCs) are limited. Using microarray analysis, the genome-wide expression profile of lncRNAs was investigated in four paired VSCCs and adjacent normal vulvar tissues. Accordingly, several novel lncRNA candidates (HOAIR, MALAT1, MEG3, NEAT1, MIR31HG and LINC00478) were chosen for further study and real-time reverse transcription PCR (RT-PCR) was used to confirm the expression levels among 35 tissue samples...
September 8, 2016: Oncology Reports
Diogo Morbeck, Aline Caldart Tregnago, Glauco Baiocchi Netto, Carlos Sacomani, Patricia Maria Peresi, Cynthia Toledo Osório, Luciana Schutz, Stephania Martins Bezerra, Louise de Brot, Isabela Werneck Cunha
AIMS: GATA3 has been reported as a specific urothelial marker among organs in the pelvic region and has been classified as highly sensitive and specific for urothelial and breast carcinomas. Our aim was to verify GATA3 expression in extramammary Paget disease (EMPD) and check if it can be use to differentiate primary vulvar Paget disease (PVPD) from pagetoid urothelial intraepithelial neoplasia (PUIN). Also we analyzed Her2 protein expression and HER2 gene amplification and its role as prognostic factors in EMPD METHODS AND RESULTS: We analyzed GATA3 and Her2 expression in 11 primary vulvar Paget disease and also 2 PUIN cases...
September 16, 2016: Histopathology
Gozde Kulhan, Mehmet Kulhan, Umit Nayki, Cenk Nayki, Pasa Ulug, Emrah Akkaya, Onur S Aldemir, Yusuf Yildirim, Mehmet Sipahi
OBJECTIVES: Our study aimed to determine the epidemiological characteristics and diagnostic and treatment protocols of primary vaginal carcinoma. Also, we compared the clinical and pathological features of primary vaginal carcinoma which intersect with cervical and vulvar carcinomas. MATERIAL AND METHODS: Sixteen patients with primary vaginal carcinoma, admitted to the Department of Gynecologic Oncology, Izmir Tepecik Training and Research Hospital between January 1983 and December 2012, were evaluated retrospectively...
2016: Ginekologia Polska
Sarah Leonard, Merlin Pereira, Richard Fox, Naheema Gordon, Jason Yap, Sean Kehoe, David Luesley, Ciaran Woodman, Raji Ganesan
OBJECTIVE: Cancer initiation and progression has been linked to aberrant expression of the DNA methyltransferases (DNMT), the enzymes which establish and maintain DNA methylation patterns throughout the genome. In this study, we investigated if DNMT expression in vulvar squamous cell carcinomas (VSCC) was related to clinical outcome. METHODS: DNMT1, DNMT3A and DNMT3B expression was measured in a subset of cases drawn from a cohort of consecutive women treated for primary VSCC at the Pan Birmingham Gynaecological Cancer Centre between 2001 and 2008...
September 9, 2016: Gynecologic Oncology
Jonathan M Soh, Glynis A Scott, Brian T Pavlovitz, Mary Gail Mercurio
No abstract text is available yet for this article.
September 10, 2016: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
Marta Félez-Sánchez, Marleny Vergara, Silvia de Sanjosé, Xavier Castellsagué, Laia Alemany, Ignacio G Bravo
Human Papillomaviruses (HPVs) are involved in the etiology of anogenital and head and neck cancers. The HPV DNA prevalence greatly differs by anatomical site. Indeed, the high rates of viral DNA prevalence in anal and cervical carcinomas contrast with the lower fraction of cancer cases attributable to HPVs in other anatomical sites, chiefly the vulva, the penis and head and neck. Here we analyzed 2635 Formalin Fixed Paraffin Embedded surgical samples that had previously tested negative for the presence of HPVs DNA using the SPF10/DEIA procedure, in order to identify the presence of other PVs not explicitly targeted by standard molecular epidemiologic approaches...
September 4, 2016: Infection, Genetics and Evolution
Ch Tsvetkov, G Gorchev, S Tomov, M Nikolova, G Genchev
AIM: The aim of the research was to evaluate and analyse prognosis and prognostic factors in patients with squamous cell vulvar carcinoma after primary surgery with individual approach applied during the course of treatment. MATERIALS AND METHODS: In the period between January 2000 and July 2010, 113 patients with squamous cell carcinoma of the vulva were diagnosed and operated on at Gynecologic Oncology Clinic of Medical University, Pleven. All the patients were monitored at the same clinic...
2016: Akusherstvo i Ginekologii︠a︡
Lisa Barbera, Lilian T Gien, Rinku Sutradhar, Gillian Thomas, Al Covens, Laurie Elit, Anthony Fyles, Eileen Rakovitch, Ying Liu, Mahmoud Khalifa
We conducted a population-based patterns of care study of vulvar carcinoma. This paper describes the changes in reporting based on pathology review. This is a retrospective population-based cohort study. We obtained all pathology records available from the provincial cancer registry for primary invasive squamous cell carcinoma of the vulva diagnosed between 1998 and 2007. Pathology reviews were conducted centrally by a group of gynecologic pathologists and were identified during abstraction. Corresponding original reports were matched to pathology review reports based on accession numbers...
August 10, 2016: International Journal of Gynecological Pathology
Mirna B Podoll, Naveena Singh, C Blake Gilks, Mana Moghadamfalahi, Mary Ann Sanders
Differentiated vulvar intraepithelial neoplasia (dVIN), precursor of vulvar squamous cell carcinoma, is human papilloma virus independent and often found in a background of lichen sclerosus (LS) and lichen simplex chronicus (LSC). Subtle histologic findings make the diagnosis of dVIN difficult, and, although the use of p53 and Ki-67 has been of some value, there is a need for a better immunohistochemical marker. Cytokeratin 17 (CK17), a cytoskeletal intermediate filament protein, has previously been used in the diagnosis of anogenital lesions...
August 10, 2016: International Journal of Gynecological Pathology
L S Nooij, M A van der Slot, O M Dekkers, T Stijnen, K N Gaarenstroom, C L Creutzberg, V T H B M Smit, T Bosse, M I E van Poelgeest
BACKGROUND: There is no consensus on the width of tumour-free margins after surgery for vulvar squamous cell carcinoma (VSCC). Most current guidelines recommend tumour-free margins of ≥8 mm. The aim of this study was to investigate whether a margin of <8 mm is associated with an increased risk of local recurrence in VSCC. METHODS: A meta-analysis of the available literature and a cohort study of 148 VSCC patients seen at a referral centre from 2000 to 2012 was performed...
September 2016: European Journal of Cancer
Nayi Zongo, Nina Korsaga-Somé, Amandine Banata Gang-Ny, Edgar Ouangré, Maurice Zida, Aimé Sosthène Ouédraogo, Aboubacar Hirrhum Bambara, Augustin Tozoula Bambara, Si Simon Traore, Pascal Niamba, Adama Traoré, Ahmadou Dem
BACKGROUND: Vulvar cancer is a rare gynaecological cancer. In Burkina Faso, the diagnosis of vulvar cancers is delayed and the prognosis is poor. However, no specific study on vulvar cancers has been conducted at the moment. This work aimed to study the characteristics of these cancers. METHODS: This is a prospective study on histologically confirmed primary cancers of the vulva diagnosed between 1st January 2013 and 30th June 2015. The demographic and clinical aspects were studied at the Yalgado Ouedraogo University Hospital of Ouagadougou (CHU-YO)...
2016: Infectious Agents and Cancer
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