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Vulvar carcinoma

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https://www.readbyqxmd.com/read/29336837/effectiveness-of-definitive-radiotherapy-for-squamous-cell-carcinoma-of-the-vulva-with-gross-inguinal-lymphadenopathy
#1
Shane R Stecklein, Michael Frumovitz, Ann H Klopp, Jillian R Gunther, Patricia J Eifel
OBJECTIVE: To evaluate the effectiveness and long-term side effects of definitive groin radiotherapy for vulvar cancer with grossly involved inguinal lymph nodes. METHODS: The records of 407 women with vulvar squamous cell carcinoma treated with radiotherapy at one institution during 1992-2014 were reviewed to identify patients who had radiographic or histologic evidence of grossly involved inguinal lymph nodes. Patients with lymphadenectomy before radiotherapy and patients treated for recurrent disease were excluded...
January 11, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29324545/the-role-of-pathological-margin-distance-and-prognostic-factors-after-primary-surgery-in-squamous-cell-carcinoma-of-the-vulva
#2
Macit Arvas, Ilker Kahramanoglu, Tugan Bese, Hasan Turan, Isik Sozen, Sennur Ilvan, Fuat Demirkiran
OBJECTIVE: The aim of this study was to determine the impact of clear surgical margin distance and other factors associated with the recurrence and survival of patients with squamous cell carcinoma of the vulva. METHODS/MATERIALS: A total of 107 patients operated for vulvar carcinoma from 1996 to 2016 were included in the analysis. Patients were divided into subgroups with clear pathological margin of 2 mm or less, greater than 2 to less than 8 mm, and 8 mm or greater for the analysis of the prognostic impact of the clear margin distance...
January 10, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29299981/normalizers-for-microrna-quantification-in-plasma-of-patients-with-vulvar-intraepithelial-neoplasia-lesions-and-vulvar-carcinoma
#3
Kamil Zalewski, Marcin Misiek, Artur Kowalik, Elwira Bakuła-Zalewska, Janusz Kopczyński, Aleksandra Zielińska, Mariusz Bidziński, Jakub Radziszewski, Stanisław Góźdź, Magdalena Kowalewska
The role of circulating microRNAs as a promising tool for diagnosing cancer and monitoring anticancer therapies has been widely studied in the past decades. To date, no suitable reference microRNAs for normalizing quantitative real-time polymerase chain reaction assays has been identified in vulvar intraepithelial neoplasia lesions and vulvar squamous cell carcinoma. The purpose of this study was to select appropriate references for gene expression studies in plasma of patients with these lesions. Expression levels of six microRNAs-hsa-miR-425-5p, hsa-miR-191-5p, hsa-miR-93-5p, hsa-miR-423-5p, hsa-miR-103a-3p, and hsa-miR-16-5p-were analyzed by quantitative reverse transcription polymerase chain reaction in plasma samples obtained from 17 patients with vulvar intraepithelial neoplasia lesion and 27 patients with vulvar squamous cell carcinoma...
November 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29295880/evaluation-of-ajcc-and-an-alternative-tumor-classification-system-for-primary-vulvar-squamous-cell-carcinoma
#4
Sarah T Le, Pritesh S Karia, Beverley J Vollenhoven, Robert J Besaw, Colleen M Feltmate, Chrysalyne D Schmults
Background: Currently, no studies have attempted to validate the AJCC tumor (T) class for vulvar cancer or examine its performance via clinical data. The goal of this study was to identify risk factors associated with poor outcomes in vulvar squamous cell carcinoma (vSCC) and compare prognostic discrimination of these outcomes between the AJCC T-classification system and the newly developed Brigham and Women's Vulvar Tumor Classification system (BWVTC). Methods: A 15-year, 2-center retrospective cohort study of primary vSCCs (N=226) was undertaken...
January 2018: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29225558/vulvar-squamous-cell-carcinoma-aggressiveness-is-associated-with-differential-expression-of-collagen-and-stat1
#5
Emily R Holthoff, Stephanie D Byrum, Samuel G Mackintosh, Thomas Kelly, Alan J Tackett, Charles M Quick, Steven R Post
Background: Vulvar squamous cell carcinoma (vSCC) is a rare but debilitating disease. One vSCC variant comprises tumor cells that grow and expand as a cohesive sheet of cells that "pushes" and compresses the associated lymphoplasmacytic (LPC) stroma. Another vSCC variant features tumor cells that grow in loose association with one another and infiltrate the associated fibromyxoid (FMX) stroma consisting mainly of extracellular matrix. Clinically, infiltrative vSCC with FMX stroma (Inf/FMX) is significantly associated with lymph node metastases and recurrence...
2017: Clinical Proteomics
https://www.readbyqxmd.com/read/29190964/tumoral-pd-l1-expression-defines-a-subgroup-of-poor-prognosis-vulvar-carcinomas-with-non-viral-etiology
#6
Thomas Hecking, Thore Thiesler, Cynthia Schiller, Jean-Marc Lunkenheimer, Tiyasha H Ayub, Andrea Rohr, Mateja Condic, Mignon-Denise Keyver-Paik, Rolf Fimmers, Jutta Kirfel, Walther Kuhn, Glen Kristiansen, Kirsten Kübler
Vulvar cancer is rare but incidence rates are increasing due to an aging population and higher frequencies of young women being affected. In locally advanced, metastatic or recurrent disease prognosis is poor and new treatment modalities are needed. Immune checkpoint blockade of the PD-1/PD-L1 pathway is one of the most important advancements in cancer therapy in the last years. The clinical relevance of PD-L1 expression in vulvar cancer, however, has not been studied so far. We determined PD-L1 expression, numbers of CD3+ T cells, CD20+ B cells, CD68+ monocytes/macrophages, Foxp3+ regulatory T cells and CD163+ tumor-associated macrophages by immunohistochemistry in 103 patients...
November 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29183034/adjuvant-radiotherapy-in-high-risk-squamous-cell-carcinoma-of-the-vulva-a-two-institutional-italian-experience
#7
Concetta Laliscia, Maria G Fabrini, Ines Cafaro, Amelia Barcellini, Davide Baldaccini, Mario Miniati, Emanuela Parietti, Riccardo Morganti, Fabiola Paiar, Angiolo Gadducci
BACKGROUND: The aim of this study was to assess the treatment benefit and patterns of recurrence for patients with high-risk vulvar squamous cell carcinoma treated with surgery followed by adjuvant radiotherapy (RT). PATIENTS AND METHODS: From January 1999 to June 2016, 51 patients underwent total or partial deep vulvectomy with inguinofemoral lymphadenectomy followed by adjuvant RT with 45-50 Gy in 25 fractions +/- a 4-10 Gy boost. 17 (33.3%) women received concomitant chemotherapy...
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/29178840/prevalence-of-oncogenic-human-papillomavirus-genotypes-in-patients-diagnosed-with-anogenital-malignancies-in-botswana
#8
Patricia S Rantshabeng, Sikhulile Moyo, Natasha O Moraka, Andrew Ndlovu, Iain J MacLeod, Simani Gaseitsiwe, Ishmael Kasvosve
BACKGROUND: Human papillomavirus (HPV) associated malignancies are the leading cause of cancer death in Botswana. We sought to determine causative HPV types in patients with anogenital malignancies in Botswana to inform vaccine strategy. METHODS: We used formalin-fixed and paraffin-embedded (FFPE) tissue blocks from patients diagnosed with anal, penile and vulvar squamous cell carcinomas between the years, 2014 and 2016. Presence of HPV 16, 18, or other high-risk (HR) types was detected using Abbott m2000 real-time PCR platform...
November 25, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29163797/pd-l1-expression-on-immune-cells-is-a-favorable-prognostic-factor-for-vulvar-squamous-cell-carcinoma-patients
#9
Jacek J Sznurkowski, Anton Żawrocki, Katarzyna Sznurkowska, Rafał Pęksa, Wojciech Biernat
Background: Anti-immune programmed death-ligand 1 (PD-L1) pathway is used by the tumor to overcome immune system and serves as immunotherapy target in various malignancies. Aim: To investigate the expression of PD-L1 in vulvar squamous cell carcinoma (vSCC) and to assess it's clinicopathological and prognostic significance. Methods: Immunohistochemical PD-L1 expression was evaluated in 84 vSCCs with previously defined status of p16 and DNA-HPV, infiltration of immune cells: CD8+, CD4+, FOXP3+, CD56+, CD68+, and GZB+ cells...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156232/use-of-negative-pressure-wound-therapy-after-infection-and-flap-dehiscence-in-radical-vulvectomy-a-case-report
#10
Antoni Llueca, Jose Luis Herraiz, Raquel Del Moral, Dolors Piquer, Yasmine Maazouzi, Blanca Segarra, Jordan Barres, Anna Serra
INTRODUCTION: Vulvar cancer has a lower incidence in high income countries, but is rising, in part, due to the high life expectancy in these societies. Radical vulvectomy is still the standard treatment in initial stages. Wound dehiscence contitututes one of the most common postoperative complications. PRESENTATION OF CASE: A 76year old patient with a squamous cell carcinoma of the vulva, FIGO staged, IIIb is presented. Radical vulvectomy and bilateral inguinal lymph node dissection with lotus petal flaps reconstruction are performed as the first treatment...
November 6, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29145324/a-rare-case-of-merkel-cell-carcinoma-presenting-as-a-giant-intra-thoracic-mass-a-case-report-and-review-of-the-literature
#11
Feng-Wei Kong, Miao Zhang, Heng Wang, Cun-Tao Lu, Wen-Bin Wu, Yuan-Yuan Liu
RATIONALE: Merkel cell carcinoma (MCC) is an aggressive neuroendocrine-derived cutaneous cancer. Ectopic or single metastatic MCC located in thorax is extremely rare; meanwhile, its definite management has not been elucidated yet. PATIENT CONCERNS: A 64-year-old female patient with a giant mass located in her left thorax was presented for stuffy pain of left chest for 6 months and fever for half a month. She underwent radical resection of vulvar MCC 10 years ago...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29137809/prognostic-factors-for-local-recurrence-of-squamous-cell-carcinoma-of-the-vulva-a-systematic-review
#12
REVIEW
Nienke C Te Grootenhuis, Anne-Floor W Pouwer, Geertruida H de Bock, Harry Hollema, Johan Bulten, Ate G J van der Zee, Joanne A de Hullu, Maaike H M Oonk
BACKGROUND: In patients treated for early-stage squamous cell vulvar carcinoma local recurrence is reported in up to 40% after ten years. Knowledge on prognostic factors related to local recurrences should be helpful to select high risk patients and/or to develop strategies to prevent local recurrences. OBJECTIVE: This systematic review aims to evaluate the current knowledge on the incidence of local recurrences in vulvar carcinoma related to clinicopathologic and cell biologic variables...
November 12, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29135982/sting-expression-and-response-to-treatment-with-sting-ligands-in-premalignant-and-malignant-disease
#13
Jason R Baird, Zipeng Feng, Hong D Xiao, David Friedman, Ben Cottam, Bernard A Fox, Gwen Kramer, Rom S Leidner, R Bryan Bell, Kristina H Young, Marka R Crittenden, Michael J Gough
Human papilloma virus positive (HPV+) tumors represent a large proportion of anal, vulvar, vaginal, cervical and head and neck squamous carcinomas (HNSCC) and late stage invasive disease is thought to originate from a premalignant state. Cyclic dinucleotides that activate STimulator of INterferon Genes (STING) have been shown to cause rapid regression of a range of advanced tumors. We aimed to investigate STING ligands as a novel treatment for papilloma. We tested therapies in a spontaneous mouse model of papilloma of the face and anogenital region that histologically resembles human HPV-associated papilloma...
2017: PloS One
https://www.readbyqxmd.com/read/29135512/cytokeratin-profile-of-basal-cell-carcinomas-according-to-the-degree-of-sun-exposure-and-to-the-anatomical-localization
#14
Ma Reyes García-de-la-Fuente, Maria Santacana, Joan Valls, Felip Vilardell, José Manuel Fernández Armenteros, Ramon Pujol, Eloi Gari, Josep Manel Casanova
Basal cell carcinoma (BCC) seems to originate from ultraviolet light-induced mutations involving the bulge or the outer sheath of the hair follicle cells. However, the etiopathogenic mechanisms involved in the development of these tumors in nonphotoexposed and in hairless areas remain unclear. The cytokeratin (CK) profile (including CK5/6, CK7, CK14, CK15, CK17, and CK19) from a series of different BCC subtypes developing in sun-exposed and non-sun-exposed areas, including hairless regions, was evaluated. The authors have observed that CK7 expression in BCC is associated with the anatomical localization of the tumor and its sun-exposition, but not with other factors such as histological subtype...
November 1, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29109863/pattern-of-gynaecological-malignancies-in-south-western-region-of-pakistan-an-overview-of-12-years
#15
Hina Manzoor, Hamida Naheed, Khushnaseeb Ahmad, Shehla Iftikhar, Muhammad Asif, Jamila Shuja, Neelam Sultan, Irfan Ali, Syed Inayatullah, Yasir Hayat Khan
Gynaecological malignancies contribute significantly to cancer burden and have a higher rate of mortality and morbidity. The aim of this retrospective study was to determine the pattern of gynaecological malignancies identified between January, 2000 and December, 2011, at the Centre for Nuclear Medicine and Radiotherapy (CENAR). At CENAR 5,072 female patients were registered with different malignancies, of which 632 cases were gynaecological malignancies. Ovarian cancer (47%) was the most common gynaecological malignancy, followed by cervical cancer (29%), uterine cancer (14%), vulvar and vaginal cancer (6%), and gestational trophoblastic neoplasm (4%)...
November 2017: Biomedical Reports
https://www.readbyqxmd.com/read/29105738/five-year-relative-survival-for-human-papillomavirus-associated-cancer-sites
#16
Hilda Razzaghi, Mona Saraiya, Trevor D Thompson, S Jane Henley, Laura Viens, Reda Wilson
BACKGROUND: Human papillomavirus (HPV) vaccines can potentially prevent greater than 90% of cervical and anal cancers as well as a substantial proportion of vulvar, vaginal, penile, and oropharyngeal cancers caused by certain HPV types. Because more than 38,000 HPV-associated cancers are diagnosed annually in the United States, current studies are needed to understand how relative survival varies for each of these cancers by certain demographic characteristics, such as race and age. METHODS: The authors examined high-quality data from 27 population-based cancer registries covering approximately 59% of the US population...
November 6, 2017: Cancer
https://www.readbyqxmd.com/read/29090456/does-hpv-status-influence-survival-after-vulvar-cancer
#17
Christina Louise Rasmussen, Freja Laerke Sand, Marie Hoffmann Frederiksen, Klaus Kaae Andersen, Susanne K Kjaer
High-risk human papillomavirus (HPV) infection is essential in the carcinogenesis of a substantial part of anogenital and oropharyngeal cancers and has additionally been shown to be a possible predictive marker for survival, especially in oropharyngeal cancer. Studies examining the influence of HPV status on survival after vulvar cancer have been conflicting and limited by small study populations. Therefore, the aim of this review and meta-analysis was to examine whether HPV status influences survival after vulvar cancer, which, to our knowledge, has not been done before...
November 1, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28979650/-urethral-ectropion-may-hide-a-carcinoma
#18
Mohammed Alae Touzani, Othmane Yddoussalah
The incidence of female urethral cancer is rare and accounts for 0.02% of all women's cancers. It is dominated by epidermoid carcinoma, which most commonly develops in the distal portion of the urethra, extending to inguinal lymph nodes. The diagnosis is confirmed in the distal forms on the basis of uretrocystoscopy with biopsy. Abdominopelvic MRI allows to determine tumor extension as well as its infiltration into tissues and peri-urethral organs. As in superficial tumors of the distal urethra, simple circumferential resection of the urethra associated with resection of the adjacent portion of the anterior surface of the vagina is sufficient...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28958732/long-term-outcome-after-resection-of-liver-metastases-from-squamous-cell-carcinoma
#19
Kiyohiko Omichi, Takashi Mizuno, Masayuki Okuno, Ching-Wei D Tzeng, Claudius Conrad, Yun Shin Chun, Thomas A Aloia, Jean-Nicolas Vauthey
BACKGROUND: Squamous cell carcinoma (SCC) liver metastases still remains a difficult challenge and the effectiveness of resection for SCC liver metastases is unclear. The aim of this study was to analyze long-term outcomes of surgically treated patients with SCC liver metastases. METHODS: The clinicopathological characteristics, overall survival (OS), and recurrence free survival (RFS) of all patients with SCC liver metastases resected between 1998 and 2015, were analyzed...
September 13, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28954490/decreased-nk-cell-activity-after-partial-vulvectomy-in-pregnant-patient-with-vulvar-intraepithelial-neoplasia-3-vin3
#20
Malgorzata Jerzak, Andrzej Nowakowski, Monika Ohams, Andrzej Górski, Włodzimierz Baranowsk
INTRODUCTION AND OBJECTIVE: The study presents the problem of immune disturbances in pregnant women with vulvar carcinoma in situ (VIN3). MATERIAL AND METHODS: NK cell and T reg activity in the study patient were analysed using flow cytometry. RESULTS: Decreased NK cell activity and but increased T reg activity were observed after vulvectomy, with subsequent successful pregnancy outcome. CONCLUSIONS: Although vulvar cancer may influence immune cell activity, this issue merits further study...
September 21, 2017: Annals of Agricultural and Environmental Medicine: AAEM
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