Sira Karvinen, Tero Sievänen, Jari E Karppinen, Pekka Hautasaari, Geneviève Bart, Anatoliy Samoylenko, Seppo J Vainio, Juha P Ahtiainen, Eija K Laakkonen, Urho M Kujala
Background: To date, microRNAs (miRs) carried in extracellular vesicles (EVs) in response to exercise have been studied in blood but not in non-invasively collectable body fluids. In the present study, we examined whether six exercise-responsive miRs, miRs-21, -26, -126, -146, -221, and -222, respond to acute endurance exercise stimuli of different intensities in sweat. Methods: We investigated the response of miRs isolated from sweat and serum EVs to three endurance exercise protocols: (1) maximal aerobic capacity (VO2 max ), (2) anaerobic threshold (AnaT), and (3) aerobic threshold (AerT) tests...
2020: Frontiers in Physiology