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https://www.readbyqxmd.com/read/29471593/clinical-evolution-of-patients-with-new-onset-inflammatory-back-pain-a-population-based-cohort-study
#1
Runsheng Wang, Cynthia S Crowson, Kerry Wright, Michael M Ward
OBJECTIVE: Inflammatory back pain (IBP) is often an early manifestation of spondyloarthritis (SpA), but the prognosis of patients with incident IBP is unknown. We investigated the long-term outcomes of patients with IBP, and predictors of progression to SpA, in a retrospective longitudinal study of a population-based cohort. METHODS: We used the Rochester Epidemiology Project, a longstanding population-based study of residents of Olmsted County, Minnesota, USA, to identify patients aged 16 to 35 with clinical visits for back pain from 1999 to 2003...
February 22, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29471592/what-can-our-hands-tell-us-about-the-future-of-our-knees
#2
EDITORIAL
Jamie E Collins
Knee osteoarthritis (OA) affects 14 million individuals in the United States and over 250 million adults worldwide1,2 . OA of the lower extremities is associated with decreased quality of life and increased healthcare utilization3 . Recent estimates suggest that knee OA should not merely be considered a disease of aging - in the US alone more than half of those affected are under age 65, while close to 15% are under age 452 . This article is protected by copyright. All rights reserved.
February 22, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29471588/attenuated-effectiveness-of-tumor-necrosis-factor-inhibitors-for-anti-human-t-lymphotropic-virus-type-1-antibody-positive-rheumatoid-arthritis
#3
Takahisa Suzuki, Shoichi Fukui, Kunihiko Umekita, Junya Miyamoto, Masataka Umeda, Ayako Nishino, Akitomo Okada, Tomohiro Koga, Shin-Ya Kawashiri, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai, Keita Fujikawa, Toshiyuki Aramaki, Akinari Mizokami, Naoki Matsuoka, Yukitaka Ueki, Katsumi Eguchi, Shuntaro Sato, Toshihiko Hidaka, Tomoki Origuchi, Akihiko Okayama, Atsushi Kawakami, Hideki Nakamura
OBJECTIVES: We evaluated the effectiveness of tumor necrosis factor (TNF) inhibitors for the treatment of human T-lymphotropic virus type 1 (HTLV-I)-positive rheumatoid arthritis (RA) patients in an HTLV-I endemic area. METHODS: We conducted an observational study of 585 RA patients for whom TNF inhibitors were newly introduced as a first biologic disease-modifying antirheumatic drug (bDMARD) in an HTLV-I endemic area in southwestern Japan. RESULTS: Fifty patients (8...
February 22, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29471586/inflammatory-back-pain-and-axial-spondyloarthritis-lessons-for-clinical-practice-and-epidemiological-research
#4
EDITORIAL
Maureen Dubreuil, Joachim Sieper
The delay between symptom onset and diagnosis in axial spondyloarthritis (axSpA) remains unacceptably long; recently estimated to still be more than 6 years.1 Accumulating data demonstrates that early treatment with TNF-inhibitors reduces both disease activity and radiographic progression in ankylosing spondylitis, the prototypic form of axSpA.2 3 To encourage timely and correct diagnosis and enable early treatment, strategies to better identify patients with axSpA have been studied in several populations.4 This article is protected by copyright...
February 22, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29471584/vasudhaiva-kutumbakam-the-world-is-one-family
#5
Sharad Lakhanpal
Welcome to the 81st annual scientific meeting of the American College of Rheumatology in lovely San Diego, California. A special welcome to our international friends. This year the AFLAR, APLAR, EULAR and PANLAR are all contributing educational content by holding sessions in conjunction with the ACR meeting and I hope that you will enjoy both. This article is protected by copyright. All rights reserved.
February 22, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29471581/association-of-quantitative-and-topographic-assessment-of-heberden-s-nodes-with-knee-osteoarthritis-data-from-osteoarthritis-initiative
#6
Neil Kumar, Nima Hafezi-Nejad, Ali Guermazi, Arya Haj-Mirzaian, Ida K Haugen, Frank W Roemer, Shadpour Demehri
OBJECTIVE: To determine whether the presence, number, and topography (digit location and symmetry) of Heberden's nodes (HNs) are associated with radiographic knee osteoarthritis (OA) incidence and progression. METHODS: 8023 knees from the Osteoarthritis Initiative (OAI) were analyzed (8-years follow-up). Cox regression was performed on HN presence, total number, location, and symmetry (using two symmetry index models) obtained at baseline physical-examination as well as self-report of HN presence for evaluation of association with radiographic knee OA incidence (development of Kellgren-Lawrence grade≥2) and progression (worsening medial joint space narrowing score≥1)...
February 22, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29471566/mucosal-associated-invariant-t-cells-in-chronic-inflammatory-liver-disease
#7
Fabian J Bolte, Barbara Rehermann
The broadening field of microbiome research has led to a substantial reappraisal of the gut-liver axis and its role in chronic liver disease. The liver is a central immunologic organ that is continuously exposed to food and microbial-derived antigens from the gastrointestinal tract. Mucosal-associated invariant T (MAIT) cells are enriched in the human liver and can be activated by inflammatory cytokines and microbial antigens. In chronic inflammatory liver disease, MAIT cells are depleted suggesting an impaired MAIT cell-dependent protection against bacterial infections...
February 2018: Seminars in Liver Disease
https://www.readbyqxmd.com/read/29471559/-suturing-an-acute-acl-lesion-with-dynamic-intraligamentary-stabilisation
#8
Christoph Ihle, H Nakayama, Christoph Gonser, Ulrich Stöckle, Stefan Döbele, Steffen Schröter, Marc-Daniel Ahrend, Atesch Ateschrang
BACKGROUND: The established surgical technique for lesion of the anterior cruciate ligament (ACL) is reconstruction with an autologous tendon. However, patients after ACL-replacement have increased osteoarthritis rates. Possible explanations are persistent knee instability and the loss of the ACL's proprioceptive function. Therefore, surgeons have developed an alternative treatment to preserve the ACL by readapting femoral ACL lesions by temporary protective dynamic intraligamentary stabilisation (DIS)...
February 2018: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29471487/the-lesser-antillean-iguana-iguana-delicatissima-on-st-eustatius-genetically-depauperate-and-threatened-by-ongoing-hybridization
#9
Matthijs P van den Burg, Patrick G Meirmans, Tim van Wagensveld, Bart Kluskens, Hannah Madden, Mark E Welch, Johannes A J Breeuwer
The Lesser Antillean Iguana (Iguana delicatissima) is an endangered species threatened by habitat loss and hybridization with non-native Green Iguanas (Iguana iguana). Iguanadelicatissima has been extirpated on several islands, and the Green Iguana has invaded most islands with extant populations. Information is essential to protect this species from extinction. We collected data on 293 iguanas including 17 juveniles from St. Eustasius, one of the few remaining I. delicatissima strongholds. Genetic data was leveraged to test for hybridization presence with the Green Iguana using both mitochondrial and nuclear genes, including 16 microsatellite loci...
February 19, 2018: Journal of Heredity
https://www.readbyqxmd.com/read/29471475/assessing-viral-transfer-during-doffing-of-ebola-level-personal-protective-equipment-in-a-biocontainment-unit
#10
Lisa M Casanova, Kimberly Erukunuakpor, Colleen S Kraft, Joel M Mumma, Francis T Durso, Ashley N Ferguson, Christina L Gipson, Victoria L Walsh, Craig Zimring, Jennifer DuBose, Jesse T Jacob
Background: Personal protective equipment (PPE) protects healthcare workers (HCWs) caring for patients with Ebola virus disease (EVD), and PPE doffing is a critical point for preventing viral self-contamination. We assessed contamination of skin, gloves, and scrubs after doffing Ebola-level PPE contaminated with surrogate viruses: bacteriophages MS2 and Φ6. Methods: In a medical biocontainment unit, HCWs (n = 10) experienced in EVD care donned and doffed PPE following unit protocols that incorporate trained observer guidance and alcohol-based hand rub (ABHR)...
February 17, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29471464/poor-immunogenicity-not-vaccine-strain-egg-adaptation-may-explain-the-low-h3n2-influenza-vaccine-effectiveness-in-2012-13
#11
Sarah Cobey, Sigrid Gouma, Kaela Parkhouse, Benjamin S Chambers, Hildegund C Ertl, Kenneth E Schmader, Rebecca A Halpin, Xudong Lin, Timothy B Stockwell, Suman R Das, Emily Landon, Vera Tesic, Ilan Youngster, Benjamin A Pinsky, David E Wentworth, Scott E Hensley, Yonatan H Grad
Background: Influenza vaccination aims to prevent infection by influenza virus and reduce associated morbidity and mortality; however, vaccine effectiveness (VE) can be modest, especially for subtype A(H3N2). Low VE has been attributed to mismatches between the vaccine and circulating influenza strains and to the vaccine's elicitation of protective immunity in only a subset of the population. The low H3N2 VE in the 2012-2013 season was attributed to egg-adaptive mutations that created antigenic mismatch between the actual vaccine strain (IVR-165) and both the intended vaccine strain (A/Victoria/361/2011) and the predominant circulating strains (clades 3C...
February 20, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29471452/protecting-the-community-through-child-vaccination
#12
Evan J Anderson, Michael A Daugherty, Larry K Pickering, Walter A Orenstein, Ram Yogev
The direct impact of vaccines upon children is well described, but the major public health impact of indirect protection provided to the community by vaccines is under-appreciated. Community protection occurs when vaccinated people block the chain of transmission, protecting undervaccinated or unvaccinated susceptible community members by preventing exposure and limiting the spread of the pathogen through the community. Substantial declines in disease incidence have occurred shortly after implementing new childhood vaccines, including declines among vaccine-ineligible children, adolescents, and adults...
February 17, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29471432/effectiveness-of-seven-and-thirteen-valent-pneumococcal-conjugate-vaccines-in-a-schedule-without-a-booster-dose-a-ten-year-observational-study
#13
Sanjay Jayasinghe, Clayton Chiu, Helen Quinn, Rob Menzies, Robin Gilmour, Peter McIntyre
Background: Uniquely among high income countries, Australia uses a 3+0 schedule (3 primary doses; no booster) for infant pneumococcal conjugate vaccine since January 2005, initially 7-valent (PCV7) then 13-valent (PCV13) from July 2011. We measured vaccine effectiveness (VE) of both PCVs against invasive pneumococcal disease (IPD) by two methods. Method: Cases were IPD notifications to national surveillance system in children eligible for respective PCVs. For the case-control method, up to ten age-matched controls were derived from Australian Childhood Immunisation Register...
February 17, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29471427/health-and-work-in-women-and-men-in-the-welding-and-electrical-trades-how-do-they-differ
#14
Nicola Cherry, Victoria Arrandale, Jeremy Beach, Jean-Michel F Galarneau, Antonia Mannette, Laura Rodgers
Objectives: There is little information on how work tasks, demands, and exposures differ between women and men in nominally the same job. This is critical in setting workplace standards that will protect the health of both men and those women moving into less traditional work roles. Information used in setting standards is currently based almost entirely on male workers. This paper describes differences in work and health, and the relation between them, in women and men who have undergone the same trade training for the welding or electrical trades...
February 17, 2018: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/29471418/skin-specific-training-experience-of-workers-assessed-for-contact-dermatitis
#15
B Zack, V Arrandale, D L Holness
Background: Contact dermatitis is a common and preventable work-related disease. Skin-specific training may be effective for preventing occupational contact dermatitis, but little information is available regarding actual workplace training and its effectiveness. Aims: To describe workplace skin-specific training among workers with suspected contact dermatitis. Methods: Patch test patients being assessed for suspected contact dermatitis at an occupational health clinic in Toronto, Canada, completed a questionnaire on training experiences, workplace characteristics, exposures and skin protection practices...
February 17, 2018: Occupational Medicine
https://www.readbyqxmd.com/read/29471368/human-factors-risk-analyses-of-a-doffing-protocol-for-ebola-level-personal-protective-equipment-mapping-errors-to-contamination
#16
Joel M Mumma, Francis T Durso, Ashley N Ferguson, Christina L Gipson, Lisa Casanova, Kimberly Erukunuakpor, Colleen S Kraft, Victoria L Walsh, Craig Zimring, Jennifer DuBose, Jesse T Jacob
Background: Doffing protocols for personal protective equipment (PPE) are critical for keeping healthcare workers (HCWs) safe during care of patients with Ebola virus disease. We assessed the relationship between errors and self-contamination during doffing. Methods: Eleven HCWs experienced with doffing Ebola-level PPE participated in simulations in which HCWs donned PPE marked with surrogate viruses (ɸ6 and MS2), completed a clinical task, and were assessed for contamination after doffing...
February 17, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29471317/examining-duration-of-protection-should-a-booster-dose-be-part-of-all-infant-pneumococcal-conjugate-vaccine-programs
#17
Cynthia G Whitney
No abstract text is available yet for this article.
February 17, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29471244/two-sesquiterpene-aminoquinones-protect-against-oxidative-injury-in-hacat-keratinocytes-via-activation-of-ampk%C3%AE-erk-nrf2-are-ho-1-signaling
#18
Li Liu, Wei Wu, Jing Li, Wei-Hua Jiao, Li-Yun Liu, Jie Tang, Lei Liu, Fan Sun, Bing-Nan Han, Hou-Wen Lin
AIMS: To investigate the cytoprotective effects of two sesquiterpene aminoquinones isolated from the marine sponge Dysidea fragilis, Dysidaminone H (DA8) and 3'-methylamino-avarone (DA14), we examined their effects against hydrogen peroxide (H2 O2 )-induced oxidative injury in human keratinocyte cell line and elucidated the underlying mechanisms. MAIN METHODS: Cell viability was detected using a CCK-8 assay kit. Intracellular reactive oxygen species (ROS) production was measured by fluorescence of 2, 7-Dichlorodi-hydrofluorescein diacetate (DCFH-DA)...
February 19, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29471218/albumin-covered-lipid-nanocapsules-exhibit-enhanced-uptake-performance-by-breast-tumor-cells
#19
F Galisteo-González, J A Molina-Bolívar, S A Navarro, H Boulaiz, A Aguilera-Garrido, A Ramírez, J A Marchal
Liquid lipid nanocapsules (LLN) represent a promising new generation of drug-delivery systems. They can carry hydrophobic drugs in their oily core, but the composition and structure of the surrounding protective shell determine their capacity to survive in the circulatory system and to achieve their goal: penetrate tumor cells. Here, we present a study of LLN covered by the protein human serum albumin (HSA) and loaded with curcumin as a hydrophobic model drug. A cross-linking procedure was performed to further strengthen the protective protein layer...
February 13, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29471090/structure-characterization-of-two-functional-polysaccharides-from-polygonum-multiflorum-and-its-immunomodulatory
#20
Qing Zhang, Yi Xu, Junjiang Lv, Mengxia Cheng, Ying Wu, Kun Cao, Xiaofeng Zhang, Xiuni Mou, Qi Fan
Two purified polysaccharides named WPMP-1 and WPMP-2 were obtained from Polygonum multiflorum with an average molecular weight of 2.04 kDa and 92.13 kDa, respectively. Structural characterization revealed that WPMP-1was supposed to be a glucan composed of 1,4-linked α-d-Glcp, 1,4,6-linked α-d-Glcp, and terminal α-d-Glcp. WPMP-2 contained a complex branched structre formed by 1,2-linked α-d-Rhap, 1,2,4-linked α-d-Rhap, 1,3,5-linked α-l-Ara, 1,5- linked α-l-Araf, terminal α-l-Araf, 1,4-linked β-d-Galp, 1,4-linked α-d-GalpA, and 4-linked α-d-GalpA...
February 19, 2018: International Journal of Biological Macromolecules
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