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https://www.readbyqxmd.com/read/29791839/ubiquitylation-dynamics-of-the-clock-cell-proteome-and-timeless-during-a-circadian-cycle
#1
Áron Szabó, Christian Papin, David Cornu, Elisabeth Chélot, Zoltán Lipinszki, Andor Udvardy, Virginie Redeker, Ugo Mayor, François Rouyer
Circadian clocks have evolved as time-measuring molecular devices to help organisms adapt their physiology to daily changes in light and temperature. Transcriptional oscillations account for a large fraction of rhythmic protein abundance. However, cycling of various posttranslational modifications, such as ubiquitylation, also contributes to shape the rhythmic protein landscape. In this study, we used an in vivo ubiquitin labeling assay to investigate the circadian ubiquitylated proteome of Drosophila melanogaster...
May 22, 2018: Cell Reports
https://www.readbyqxmd.com/read/29791347/freeform-characterization-based-on-nanostructured-diffraction-gratings
#2
M Bichra, T Meinecke, P Fesser, L Müller, M Hoffmann, S Sinzinger
The in-line characterization of freeform optical elements during the production cycle is challenging. Recently, we presented a compact sensor setup for the characterization of the wavefront generated by freeform optical elements in transmission. The sensor is based on a common-path interferometer consisting of diffractive components and Fourier filtering being adapted to the subsequent numerical post processing. Additionally, it offers several degrees of freedom for enlarging the measurement range of the wavefront gradients...
May 10, 2018: Applied Optics
https://www.readbyqxmd.com/read/29791128/donor-acceptor-supramolecular-organic-nanofibers-as-visible-light-photoelectrocatalysts-for-hydrogen-production
#3
Liping Yang, Maomao Wang, Paul M Slattum, Benjamin R Bunes, Yuanhao Wang, Chuanyi Wang, Ling Zang
Perylene tetracarboxylic diimide (PTCDI) derivatives have been extensively studied for one-dimensional self-assembled systems and for applications in photocatalysis. Herein, we constructed a PTCDI-based donor-acceptor (D-A) supramolecular system via in situ self-assembly on an indium tin oxide (ITO) conductive glass surface. The self-assembled PTCDI nanostructures exhibit well-defined nanofibril morphologies and strong photocurrents. Interestingly, a strong and reversible electrochromic color change was observed during cyclic voltammetry (CV)...
May 23, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29790875/visible-light-induced-electropolymerization-of-suspended-hydrogel-bioscaffolds-in-a-microfluidic-chip
#4
Pan Li, Haibo Yu, Na Liu, Feifei Wang, Gwo-Bin Lee, Yuechao Wang, Lianqing Liu, Wen Jung Li
The development of microengineered hydrogels co-cultured with cells in vitro could advance in vivo bio-systems in both structural complexity and functional hierarchy, which holds great promise for applications in regenerative tissues or organs, drug discovery and screening, and bio-sensors or bio-actuators. Traditional hydrogel microfabrication technologies such as ultraviolet (UV) laser or multiphoton laser stereolithography and three-dimensional (3D) printing systems have advanced the development of 3D hydrogel micro-structures but need either expensive and complex equipment, or harsh material selection with limited photoinitiators...
May 23, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29789992/precise-and-economic-fib-sem-for-clem-with-2-nm-voxels-through-mitosis
#5
Manja Luckner, Gerhard Wanner
A portfolio is presented documenting economic, high-resolution correlative focused ion beam scanning electron microscopy (FIB/SEM) in routine, comprising: (i) the use of custom-labeled slides and coverslips, (ii) embedding of cells in thin, or ultra-thin resin layers for correlative light and electron microscopy (CLEM) and (iii) the claim to reach the highest resolution possible with FIB/SEM in xyz. Regions of interest (ROIs) defined in light microscope (LM), can be relocated quickly and precisely in SEM. As proof of principle, HeLa cells were investigated in 3D context at all stages of the cell cycle, documenting ultrastructural changes during mitosis: nuclear envelope breakdown and reassembly, Golgi degradation and reconstitution and the formation of the midzone and midbody...
May 23, 2018: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/29789673/peatland-vegetation-composition-and-phenology-drive-the-seasonal-trajectory-of-maximum-gross-primary-production
#6
Matthias Peichl, Michal Gažovič, Ilse Vermeij, Eefje de Goede, Oliver Sonnentag, Juul Limpens, Mats B Nilsson
Gross primary production (GPP) is a key driver of the peatland carbon cycle. Although many studies have explored the apparent GPP under natural light conditions, knowledge of the maximum GPP at light-saturation (GPPmax ) and its spatio-temporal variation is limited. This information, however, is crucial since GPPmax essentially constrains the upper boundary for apparent GPP. Using chamber measurements combined with an external light source across experimental plots where vegetation composition was altered through long-term (20-year) nitrogen addition and artificial warming, we could quantify GPPmax in-situ and disentangle its biotic and abiotic controls in a boreal peatland...
May 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29788929/resveratrol-induces-autophagy-dependent-apoptosis-in-hl-60-cells
#7
Yingying Fan, Jen-Fu Chiu, Jing Liu, Yan Deng, Cheng Xu, Jun Zhang, Guanwu Li
BACKGROUND: All known mechanisms of apoptosis induced by resveratrol act through cell cycle arrest and changes in mitochondrial membrane potential. It is currently unknown whether resveratrol-induced apoptosis is associated with other physiological processes, such as autophagy. METHODS: Apoptosis-related markers involved in the intrinsic and extrinsic apoptotic pathways, and autophagic markers were detected by using western blotting and immunofluorescence. Mitochondrial membrane potential was assayed by flow cytometry...
May 22, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29788219/exploiting-metamerism-to-regulate-the-impact-of-a-visual-display-on-alertness-and-melatonin-suppression-independent-of-visual-appearance
#8
Annette E Allen, Esther M Hazelhoff, Franck P Martial, Christian Cajochen, Robert J Lucas
Objectives: Artificial light sources such as visual display units (VDUs) elicit a range of subconscious and reflex light responses, including increases in alertness and suppression of pineal melatonin. Such responses employ dedicated retinal circuits encompassing melanopsin photoreceptors. Here, we aimed to determine whether this arrangement can be exploited to modulate the impact of VDUs on melatonin onset and alertness without altering visual appearance. Methods: We generated a 5-primary VDU capable of presenting metameric movies (matched for colour and luminance) but varying in melanopic-irradiance...
May 18, 2018: Sleep
https://www.readbyqxmd.com/read/29786427/diallyl-trisulfide-induces-apoptosis-of-human-papillary-thyroid-carcinoma-bcpap-cells-through-activating-mapk-signaling-pathway
#9
Jie Pan, Li Zhang, Shichen Xu, Xian Cheng, Huixin Yu, Jiandong Bao, Rong-Rong Lu
This study aimed to elucidate the potential effects of diallyl trisulfide (DATS) on human papillary thyroid carcinoma BCPAP cells and its underling mechanisms. DATS is one of the organosulfur compounds which derived from garlic. In this study, we demonstrated that compared to the solvent control, DATS treatment at concentrations of 5, 10 and 20 μΜ decreased cell survival rate of BCPAP cells to 84.51 ± 2.67%, 57.16 ± 1.18%, 41.22 ± 1.19% respectively. DATS also caused cell cycle arrest at G0/G1 phase and the proportion of cells arrested in G0/G1 phase rose from 68...
May 22, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29785903/high-intensity-light-pulses-to-reduce-microbial-load-in-fresh-cheese
#10
Valentina Lacivita, Amalia Conte, James G Lyng, Cristina Arroyo, Vittorio A Zambrini, Matteo A Del Nobile
The present study focused on the utilisation of High Intensity Light Pulses (HILP) treatment to preserve mozzarella cheese. First, the susceptibility of Pseudomonas fluorescens and Enterobacteriaceae to HILP (fluences from 0·39 to 28·0 J/cm2) in a transparent liquid was evaluated (in-vitro tests). Afterwards, the effects on inoculated mozzarella cheese were also assessed. Then untreated (Control) and HILP treated samples were packaged and stored at 10 °C for 2 weeks. Enterobacteriaceae, Pseudomonas spp. and pH were monitored during storage...
May 2018: Journal of Dairy Research
https://www.readbyqxmd.com/read/29785341/overwintering-temperature-and-body-condition-shift-emergence-dates-of-spring-emerging-solitary-bees
#11
Mariela Schenk, Oliver Mitesser, Thomas Hovestadt, Andrea Holzschuh
Solitary bees in seasonal environments must align their life-cycles with favorable environmental conditions and resources; the timing of their emergence is highly fitness relevant. In several bee species, overwintering temperature influences both emergence date and body weight at emergence. High variability in emergence dates among specimens overwintering at the same temperatures suggests that the timing of emergence also depends on individual body conditions. However, possible causes for this variability, such as individual differences in body size or weight, have been rarely studied...
2018: PeerJ
https://www.readbyqxmd.com/read/29783908/improved-timed-mating-non-invasive-method-using-fewer-unproven-female-rats-with-pregnancy-validation-via-early-body-mass-increases
#12
Agata K Stramek, Michelle L Johnson, Victoria J Taylor
For studies requiring accurate conception-timing, reliable, efficient methods of detecting oestrus reduce time and costs, whilst improving welfare. Standard methods use vaginal cytology to stage cycle, and breeders are paired-up using approximately five proven females with proven males to achieve at least one conception on a specific day. We describe an alternative, fast, consistent, non-invasive method of timed-mating using detection of lordosis behaviour in Wistar and Lister-Hooded rats that used unproven females with high success rates...
January 1, 2018: Laboratory Animals
https://www.readbyqxmd.com/read/29782816/a-new-microsporidium-apotaspora-heleios-n-g-n-sp-from-the-riverine-grass-shrimp-palaemonetes-paludosus-decapoda-caridea-palaemonidae
#13
Yuliya Y Sokolova, Robin M Overstreet
We report a new microsporidium from a key species of the estuarine communities of the Gulf States, the Riverine grass shrimp, Palaemonetes paludosus. A milky-white shrimp was found in the Mobile Bay Delta, a large, oligohaline-freshwater wetland in Alabama, USA. Light microscopy of smears and thick sections of the abdominal tissues demonstrated infection with microsporidian spores enclosed in sporophorous vesicles (SVs) in sets of eight. Broadly oval spores measured 2.9 ± 0.06 x 1.7 ± 0.03 µm (2.5-3.3 x 1...
May 18, 2018: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/29779871/non-canonical-phototransduction-mediates-synchronization-of-the-drosophila-melanogaster-circadian-clock-and-retinal-light-responses
#14
Maite Ogueta, Roger C Hardie, Ralf Stanewsky
The daily light-dark cycles represent a key signal for synchronizing circadian clocks. Both insects and mammals possess dedicated "circadian" photoreceptors but also utilize the visual system for clock resetting. In Drosophila, circadian clock resetting is achieved by the blue-light photoreceptor cryptochrome (CRY), which is expressed within subsets of the brain clock neurons. In addition, rhodopsin-expressing photoreceptor cells contribute to light synchronization. Light resets the molecular clock by CRY-dependent degradation of the clock protein Timeless (TIM), although in specific subsets of key circadian pacemaker neurons, including the small ventral lateral neurons (s-LNvs), TIM and Period (PER) oscillations can be synchronized by light independent of CRY and canonical visual Rhodopsin phototransduction...
April 30, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29779379/phase-segregation-in-potassium-doped-lead-halide-perovskites-from-39k-solid-state-nmr-at-21-1-t
#15
Dominik J Kubicki, Daniel Prochowicz, Albert Hofstetter, Shaik Mohammed Zakeeruddin, Michael Grätzel, Lyndon Emsley
Organic-inorganic lead halide perovskites are a promising family of light absorbers for a new generation of solar cells, with reported efficiencies currently exceeding 22%. A common problem of solar cells fabricated using these materials is that their efficiency depends on their cycling history, an effect known as current-voltage (J-V) hysteresis. Potassium doping has recently emerged as a universal way to overcome this adverse phenomenon. While the atomistic origins of J-V hysteresis are still not fully understood, it is essential to rationalize the atomic-level effect of protocols that lead to its suppression...
May 21, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29779216/glutamate-metabolism-in-cerebral-mitochondria-after-ischemia-and-post-ischemic-recovery-during-aging-relationships-with-brain-energy-metabolism
#16
Federica Ferrari, Antonella Gorini, Siegfried Hoyer, Roberto Federico Villa
Glutamate is involved in cerebral ischemic injury, but its role has not been completely clarified and studies are required to understand how minimize its detrimental effects, contemporarily boosting the positive ones. In fact, glutamate is not only a neurotransmitter, but primarily a key metabolite for brain bioenergetics. Thus, we investigated the relationships between glutamate and brain energy metabolism in an in vivo model of complete cerebral ischemia of 15 min and during post-ischemic recovery after 1, 24, 48, 72 and 96 hrs in 1 year- adult and 2 year-old aged rats...
May 20, 2018: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29779078/effects-of-elevated-pressure-on-pseudanabaena-galeata-b%C3%A3-cher-in-varying-light-and-dark-environments
#17
Helayaye Damitha Lakmali Abeynayaka, Takashi Asaeda, M Harun Rashid
To understand the effect of the hydrostatic pressure on Pseudanabaena galeata Böcher cells in both stratified and frequently mixed lakes, separate laboratory-scale models were developed. The pressure conditions in the stratified and mixed lakes were simulated in those models, and the variations of the cell and chlorophyll-a (Chl-a) concentration were analyzed. It was observed that an increase in pressure and darkness significantly reduced the cell concentration and pigmentation in P. galeata (p < 0...
May 19, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29778521/vasculature-on-the-clock-circadian-rhythm-and-vascular-dysfunction
#18
REVIEW
Sandra Crnko, Martin Cour, Linda W Van Laake, Sandrine Lecour
The master mammalian circadian clock (i.e. central clock), located in the suprachiasmatic nucleus of the hypothalamus, orchestrates the synchronization of the daily behavioural and physiological rhythms to better adapt the organism to the external environment in an anticipatory manner. This central clock is entrained by a variety of signals, the best established being light and food. However, circadian cycles are not simply the consequences of these two cues but are generated by endogenous circadian clocks...
May 17, 2018: Vascular Pharmacology
https://www.readbyqxmd.com/read/29778223/circadian-and-irradiance-effects-on-expression-of-antenna-protein-genes-and-pigment-contents-in-dinoflagellate-prorocentrum-donghaiense-dinophycae
#19
Xinguo Shi, Ling Li, Senjie Lin
PCP and acpPC are the two major antennae proteins that bind pigments in peridinin-containing dinoflagellates. The relationship between antennae proteins and cellular pigments at molecular level is still poorly understood. Here we identified and characterized the two antennae protein genes in dinoflagellate Prorocentrum donghaiense under different light conditions. The mature PCP protein was 32 kDa, while acpPC was a polyprotein each of 19 kDa. Both genes showed higher expression under low light than under high light, suggesting their possible role in a low light adaptation mechanism...
May 2018: Harmful Algae
https://www.readbyqxmd.com/read/29778081/molecular-aspect-of-silver-nanoparticles-regulated-embryonic-development-in-zebrafish-danio-rerio-by-oct-4-expression
#20
Biplab Sarkar, Suresh K Verma, Javed Akhtar, Surya Prakash Netam, Sanjay Kr Gupta, Pritam Kumar Panda, Koel Mukherjee
With the enhancement of commercial manifestation of silver nanoparticles, concerned has risen on their accumulation in aquatic system and consequent effects on fish development and metabolism. In this study, experiments were conducted to assess the impacts of silver nanoparticles on early life cycles of fish considering Zebrafish (Danio rerio) as experimental model. Silver nanoparticles were synthesized through chemical reduction method and characterized through UV-visible spectroscopy, dynamic light scattering (DLS), and HR-TEM...
May 4, 2018: Chemosphere
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