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https://www.readbyqxmd.com/read/29166495/photodynamic-action-of-the-red-laser-on-propionibacterium-acnes
#1
Rogério Rodrigo Ramos, Jeferson Leandro de Paiva, José Paulo Franco Dos Santos Gomes, Nagib Pezati Boer, José Maria Pereira de Godoy, Fernando Batigalia
BACKGROUND: Photodynamic therapy is a therapeutic modality that has consolidated its activity in the photooxidation of organic matter, which arises from the activity of reactive oxygen species. OBJECTIVE: To evaluate the effect of red laser 660nm with the photosensitizer methylene blue on Propionibacterium acnes in vitro. METHOD: The experimental design was distributed into four groups (1 - control group without the application of light and without photosensitizer, 2 - application of light, 3 - methylene blue without light, and 4 - methylene blue with light)...
September 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29166006/coptem-a-model-to-investigate-the-factors-driving-crude-oil-pipeline-transportation-emissions
#2
Nicolas Choquette-Levy, Margaret Zhong, Heather L MacLean, Joule A Bergerson
Previous transportation fuel life cycle assessment studies have not fully accounted for the full variability in the crude oil transport stage - e.g. transporting a light crude through a high-diameter pipeline, vs. transporting a heavy crude through a small-diameter pipeline. We develop a first principles, fluid mechanics-based crude oil pipeline transportation emissions model (COPTEM) that calculates the greenhouse gas (GHG) emissions associated with pipeline transport as a function of crude oil parameters, pipeline dimensions, and external factors...
November 22, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29165352/antibody-based-protective-immunity-against-helminth-infections-antibody-phage-display-derived-antibodies-against-bmr1-antigen
#3
Anizah Rahumatullah, Izzati Zahidah Abdul Karim, Rahmah Noordin, Theam Soon Lim
Helminth parasite infections are significantly impacting global health, with more than two billion infections worldwide with a high morbidity rate. The complex life cycle of the nematodes has made host immune response studies against these parasites extremely difficult. In this study, we utilized two phage antibody libraries; the immune and naïve library were used to identify single chain fragment variable (scFv) clones against a specific filarial antigen (BmR1). The V-gene analysis of isolated scFv clones will help shed light on preferential VDJ gene segment usage against the filarial BmR1 antigen in healthy and infected states...
November 22, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29165002/adrenal-dependent-and-independent-stress-induced-per1-mrna-in-hypothalamic-paraventricular-nucleus-and-prefrontal-cortex-of-male-and-female-rats
#4
Lauren E Chun, Jenny Christensen, Elizabeth R Woodruff, Sarah J Morton, Laura R Hinds, Robert L Spencer
Oscillating clock gene expression gives rise to a molecular clock that is present not only in the body's master circadian pacemaker, the hypothalamic suprachiasmatic nucleus (SCN), but also in extra-SCN brain regions. These extra-SCN molecular clocks depend on the SCN for entrainment to a light:dark cycle. The SCN has limited neural efferents, so it may entrain extra-SCN molecular clocks through its well-established circadian control of glucocorticoid hormone secretion. Glucocorticoids can regulate the normal rhythmic expression of clock genes in some extra-SCN tissues...
November 22, 2017: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/29164850/exploring-highly-reversible-1-5-electron-reactions-v3-v4-v5-in-na3vcr-po4-3-cathode-for-sodium-ion-batteries
#5
Rui Liu, Guiliang Xu, Qi Li, Shiyao Zheng, Guorui Zheng, Zhengliang Gong, Yixiao Li, Elizaveta Kruskop, Riqiang Fu, Zonghai Chen, Khalil Amine, Yong Yang
Development of highly reversible multi-electron reaction per redox center in NASICON-structured cathode materials is desired to improve the energy density of Sodium-ion batteries. Here, we investigated more than one electron storage of Na in Na3VCr(PO4)3. Combining a series of advanced characterization techniques such as ex situ 51V solid-state nuclear magnetic resonance, X-ray absorption near edge structure and in situ X-ray diffraction, we reveal that, V3+/V4+ and V4+/V5+ redox couples in the materials can be accessed, leading to 1...
November 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29164714/very-green-photosynthesis-of-gold-nanoparticles-by-a-living-aquatic-plant-photoreduction-of-au-iii-by-the-seaweed-ulva-armoricana
#6
Ofhani Christopher Mukhoro, Wiets D Roos, Mohammed Jaffer, John J Bolton, Martin J Stillman, Denzil R Beukes, Edith Antunes
Light-assisted in vivo synthesis of gold nanoparticles (NPs) from aqueous solutions of dilute Au(III) salts by a living green marine seaweed (Ulva armoricana) is reported for the first time. NPs synthesis using typical procedures have many associated environmental hazards. The reported methods involve green, nontoxic, eco-friendly synthetic procedures. The formation of AuNPs was extremely rapid (~15 minutes) following illumination of the living U. armoricana, while the rate of NP formation in the dark was very slow (over 2 weeks)...
November 22, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29164632/characterization-of-nanodot-optically-stimulated-luminescence-detectors-and-high-sensitivity-mcp-n-thermoluminescent-detectors-in-the-40-300-kvp-energy-range
#7
Yannick Poirier, Svetlana Kuznetsova, Jose Eduardo Villarreal-Barajas
PURPOSE: To investigate empirically the energy dependence of the detector response of two in-vivo luminescence detectors, LiF:Mg,Cu,P (MCP-N) high-sensitivity TLDs and Al2 O3 :C OSLDs, in the 40-300-kVp energy range in the context of in-vivo surface dose measurement. As these detectors become more prevalent in clinical and pre-clinical in-vivo measurements, knowledge of the variation of the empirical dependence of the measured response of these detectors across a wide spectrum of beam qualities is important...
November 22, 2017: Medical Physics
https://www.readbyqxmd.com/read/29163218/exosomes-and-metabolic-function-in-mice-exposed-to-alternating-dark-light-cycles-mimicking-night-shift-work-schedules
#8
Abdelnaby Khalyfa, Valeriy A Poroyko, Zhuanhong Qiao, Alex Gileles-Hillel, Ahamed A Khalyfa, Mahzad Akbarpour, Isaac Almendros, Ramon Farré, David Gozal
Sleep is an important modulator of metabolic function. Disruptions of sleep in circadian rhythm are common in modern societies and are associated with increased risk of developing cardiometabolic disorders. Exosomes are ubiquitous extracellular vesicles that may play a mechanistic role in metabolic derangements. We hypothesized that alternating dark-light cycles mimicking shift work in mice would alter fecal microbiota and colonic epithelium permeability and alter plasma exosome cargo and metabolic function...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29163208/circadian-alterations-in-a-murine-model-of-hypothalamic-glioma
#9
José M Duhart, Lucila Brocardo, Carlos S Caldart, Luciano Marpegan, Diego A Golombek
The mammalian circadian system is controlled by a central oscillator located in the suprachiasmatic nuclei (SCN) of the hypothalamus, in which glia appears to play a prominent role. Gliomas originate from glial cells and are the primary brain tumors with the highest incidence and mortality. Optic pathway/hypothalamic gliomas account for 4-7% of all pediatric intracranial tumors. Given the anatomical location, which compromises both the circadian pacemaker and its photic input pathway, we decided to study whether the presence of gliomas in the hypothalamic region could alter circadian behavioral outputs...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29162912/histamine-n-methyltransferase-regulates-aggression-and-the-sleep-wake-cycle
#10
Fumito Naganuma, Tadaho Nakamura, Takeo Yoshikawa, Tomomitsu Iida, Yamato Miura, Anikó Kárpáti, Takuro Matsuzawa, Atushi Yanai, Asuka Mogi, Takatoshi Mochizuki, Nobuyuki Okamura, Kazuhiko Yanai
Histamine is a neurotransmitter that regulates diverse physiological functions including the sleep-wake cycle. Recent studies have reported that histaminergic dysfunction in the brain is associated with neuropsychiatric disorders. Histamine N-methyltransferase (HNMT) is an enzyme expressed in the central nervous system that specifically metabolises histamine; yet, the exact physiological roles of HNMT are unknown. Accordingly, we phenotyped Hnmt knockout mice (KO) to determine the relevance of HNMT to various brain functions...
November 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29162139/effect-of-aging-and-curing-mode-on-the-compressive-and-indirect-tensile-strength-of-resin-composite-cements
#11
Nadja Rohr, Jens Fischer
BACKGROUND: Resin composite cements are used in dentistry to bond ceramic restorations to the tooth structure. In the oral cavity these cements are subjected to aging induced by masticatory and thermal stresses. Thermal cycling between 5 and 55 °C simulates the effect of varying temperatures in vitro. Purpose of this study was to compare indirect tensile to compressive strength of different cements before and after thermal cycling. The effect of the curing mode was additionally assessed...
November 21, 2017: Head & Face Medicine
https://www.readbyqxmd.com/read/29161481/-eco-epidemiological-aspects-natural-detection-and-molecular-identification-of-leishmania-spp-in-lutzomyia-reburra-lutzomyia-barrettoi-majuscula-and-lutzomyia-trapidoi
#12
Jazzmín Arrivillaga-Henríquez, Sandra Enríquez, Vanessa Romero, Gustavo Echeverría, Jorge Pérez-Barrera, Ana Poveda, Juan-Carlos Navarro, Alon Warburg, Washington Benítez
INTRODUCTION: The province of Pichincha in Ecuador is an endemic area of cutaneous leishmaniasis, where anthropophilic sand flies with natural infection by Leishmania, have been reported as vectors. However, the role in transmission of zoophilic species has not been evaluated. OBJECTIVE: To evaluate natural infection by Leishmania in two zoophilic phlebotomine sand fly species, Lutzomyia reburra and Lu. barrettoi majuscula, and one anthropophilic species, Lu. trapidoi, as well as the endophagy and synanthropism of these species in the northwest of Pichincha...
March 29, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/29159700/expression-and-distribution-patterns-of-spermine-spermidine-and-putrescine-in-rat-hair-follicle
#13
Yutaro Yamamoto, Takamitsu Makino, Hideo Kudo, Hironobu Ihn, Yasuko Murakami, Senya Matsufuji, Kunio Fujiwara, Masashi Shin
No expression and distribution patterns of polyamines (PAs), spermine, spermidine, and their precursor putrescine in mammalian hair follicle are available, although polyamines are known to correlate well with hair growth and epidermal tumor genesis. Immunohistochemistry (IHC) using our original two monoclonal antibodies (mAbs) ASPM-29 specific for spermine or spermidine, and APUT-32 specific for putrescine allowed us to detect immunoreactivity for polyamines in hair follicles from normal adult rats. A wide range of immunoreactivity for the total spermine and spermidine was observed in the compartments of hair follicle: The highest degree of immunoreactivity for polyamines was observed in the matrix, in the Huxley's layer, in the deeper Henle's layer, and in the cuticle of the inner root sheath/the hair cuticle, while moderate immunoreactivity existed in the lower-to-mid cortex and the companion layer, followed by lower immunoreactivity in the outer root sheath, including the bulge region and in the deeper medulla, in which the immunoreactivity was also evident in their nuclei...
November 21, 2017: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/29159661/safety-of-clomiphene-citrate-a-literature-review
#14
REVIEW
Serkan Yilmaz, Neslihan Yilmaz Sezer, İlknur Münevver Gönenç, Sibel Erkal İlhan, Ebru Yilmaz
Clomiphene citrate (CC) is a nonsteroidal compound and induces ovulation indirectly. The wide usage of the CC raises a question; is it safe or not? In the light of this question, this review aimed to highlight all researches and insights into the association between the use of CC and risk of genotoxicity, cytotoxicity, embryotoxicity, teratogenicity and risk of different cancer types. We conducted a MEDLINE/PubMed, Scopus, Web of Science, Google Scholar search. After a careful screening process of all authors, 32 of these articles were considered as appropriate, and reviewed...
November 20, 2017: Cytotechnology
https://www.readbyqxmd.com/read/29159178/zinc-containing-hydroxyapatite-enhances-cold-light-activated-tooth-bleaching-treatment-in-vitro
#15
Yi Li, Xinchang Shi, Wei Li
Cold-light bleaching treatment has grown to be a popular tooth whitening procedure in recent years, but its side effect of dental enamel demineralization is a widespread problem. The aim of this study was to synthesize zinc-substituted hydroxyapatite as an effective biomaterial to inhibit demineralization or increase remineralization. We synthesized zinc-substituted hydroxyapatite containing different zinc concentrations and analysed the product using X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, and energy dispersive spectrometer (EDS)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29156864/evaluation-of-lipid-profiles-in-patients-treated-with-capecitabine
#16
Nursel Sürmelioğlu, Semra Paydaş, Yusuf Karataş, Gülşah Seydaoğlu
Background/aim: Capecitabine is a prodrug of 5-fluorouracil and has shown significant antitumor activity. The main adverse effects are hand-foot syndrome, diarrhea, and dermatitis. In recent years, hypertriglyceridemia has been reported in patients treated with capecitabine. Dyslipidemia is a rare but important side effect of capecitabine. The aim of this study is to examine the changes in lipid levels during capecitabine treatment and to raise awareness of pharmacovigilance. Materials and methods: In this retrospective study, it was aimed to analyze lipid metabolism after capecitabine treatment and is intended to contribute to the formation of a pharmacoepidemiological database...
August 23, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29156237/skeleton-skin-structured-rgo-cnts-pani-composite-fiber-electrodes-with-excellent-mechanical-and-electrochemical-performance-for-all-solid-state-symmetric-supercapacitors
#17
Dong Liu, Pengcheng Du, Wenli Wei, Hongxing Wang, Qi Wang, Peng Liu
Polyaniline coated reduced graphene oxide/carbon nanotube composite fibers ((RGO/CNTs)@PANI, RCP) with skeleton/skin structure are designed as fiber-shaped electrodes for high performance all-solid-state symmetric supercapacitor. The one-dimensional reduced graphene oxide/carbon nanotube composite fibers (RGO/CNTs, RC) are prepared via a simple in-situ reduction of graphene oxide in presence of carbon nanotubes in quartz glass pipes, which exhibit excellent mechanical performance of >193.4 MPa of tensile strength...
November 10, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29155851/pac1-and-vpac2-receptors-in-light-regulated-behavior-and-physiology-studies-in-single-and-double-mutant-mice
#18
Jens Hannibal, Birgitte Georg, Jan Fahrenkrug
The two sister peptides, pituitary adenylate cyclase activating polypeptide (PACAP) and vasoactive intestinal polypeptide (VIP) and their receptors, the PAC1 -and the VPAC2 receptors, are involved in regulation of the circadian timing system. PACAP as a neurotransmitter in the retinohypothalamic tract (RHT) and VIP as a neurotransmitter, involved in synchronization of SCN neurons. Behavior and physiology in VPAC2 deficient mice are strongly regulated by light most likely as a result of masking. Consequently, we used VPAC2 and PAC1/VPAC2 double mutant mice in comparison with PAC1 receptor deficient mice to further elucidate the role of PACAP in the light mediated regulation of behavior and physiology of the circadian system...
2017: PloS One
https://www.readbyqxmd.com/read/29155847/context-and-culture-associated-with-alcohol-use-amongst-youth-in-major-urban-cities-a-cross-country-population-based-survey
#19
Anne W Taylor, Bridgette M Bewick, Alfred B Makanjuola, Ling Qian, Valentina V Kirzhanova, Paulo Alterwain
BACKGROUND: Alcohol consumption patterns are dependent upon culture and context. The aim of this study was to interview people aged 18-34 year old living in four cities in different regions of the world to explore differences in a range of alcohol measures to assist in determining culturally appropriate alcohol initiatives for this age group. METHOD: Multistage random sampling was consistent across the four cities (Ilorin (Nigeria), Wuhan (China), Montevideo (Uruguay) and Moscow (Russia))...
2017: PloS One
https://www.readbyqxmd.com/read/29155841/habitat-and-soil-related-drivers-of-the-root-associated-fungal-community-of-quercus-suber-in-the-northern-moroccan-forest
#20
Fatima Zahra Maghnia, Younes Abbas, Frédéric Mahé, Benaissa Kerdouh, Estelle Tournier, Mohamed Ouadji, Pierre Tisseyre, Yves Prin, Naïma El Ghachtouli, Salah Eddine Bakkali Yakhlef, Robin Duponnois, Hervé Sanguin
Soil fungi associated with plant roots, notably ectomycorrhizal (EcM) fungi, are central in above- and below-ground interactions in Mediterranean forests. They are a key component in soil nutrient cycling and plant productivity. Yet, major disturbances of Mediterranean forests, particularly in the Southern Mediterranean basin, are observed due to the greater human pressures and climate changes. These disturbances highly impact forest cover, soil properties and consequently the root-associated fungal communities...
2017: PloS One
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