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https://www.readbyqxmd.com/read/28088632/nanosized-complexation-assemblies-housed-inside-reverse-micelles-churn-out-monocytic-delivery-cores-for-bendamustine-hydrochloride
#1
Yuvraj Singh, Anumandla Chandrashekhar, Jaya Gopal Meher, K K Durga Rao Viswanadham, Vivek K Pawar, Kavit Raval, Komal Sharma, Pankaj K Singh, Animesh Kumar, Manish K Chourasia
OBJECTIVE: We explore a plausible method of targeting bendamustine hydrochloride (BM) to circulatory monocytes by exploiting their intrinsic endocytic/phagocytic capability. METHODS: We do so by complexation of sodium alginate and chitosan inside dioctyl sulfo succinate sodium (AOT) reverse micelles to form bendamustine hydrochloride loaded nanoparticles (CANPs). Dynamic light scattering, electrophoretic mobility and UV spectroscopy were used to detail intra-micellar complexation dynamics and to prove that drug was co-captured during interaction of carbohydrate polymers...
January 11, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28087763/circadian-kinetics-of-cell-cycle-progression-in-adult-neurogenic-niches-of-a-diurnal-vertebrate
#2
Veronica Akle, Alexander J Stankiewicz, Vasili Kharchenko, Lili Yu, Peter V Kharchenko, Irina V Zhdanova
: The circadian system may regulate adult neurogenesis via intracellular molecular clock mechanisms or by modifying the environment of neurogenic niches, with daily variation in growth factors or nutrients depending on the animal's diurnal or nocturnal life-style. In a diurnal vertebrate, zebrafish, we studied circadian distribution of immunohistochemical markers of the cell division cycle (CDC) in five of the sixteen neurogenic niches of adult brain, the dorsal telencephalon, habenula, preoptic area, hypothalamus and cerebellum...
January 13, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28087478/renal-involvement-in-lysinuric-protein-intolerance-contribution-of-pathology-to-assessment-of-heterogeneity-of-renal-lesions
#3
Emmanuel Estève, Pauline Krug, Aurélie Hummel, Jean-Baptiste Arnoux, Olivia Boyer, Anais Brassier, Pascale de Lonlay, Vincent Vuiblet, Stéphanie Gobin, Rémi Salomon, Christine Piètrement, Jean-Paul Bonnefont, Aude Servais, Louise Galmiche
Lysinuric protein intolerance (LPI) is a rare autosomal recessive disease caused by mutations in the SLC7A7 gene encoding the light subunit of a cationic amino acid transporter. Symptoms mimic primary urea cycle defects but dysimmune symptoms are also described. Renal involvement in LPI was first described in the 1980's. In 2007, it appeared that it could concern as much as 75% of LPI patients and could lead to end stage renal disease. The most common feature is proximal tubular dysfunction and nephrocalcinosis but glomerular lesions are also reported...
January 10, 2017: Human Pathology
https://www.readbyqxmd.com/read/28081236/a-key-marine-diazotroph-in-a-changing-ocean-the-interacting-effects-of-temperature-co2-and-light-on-the-growth-of-trichodesmium-erythraeum-ims101
#4
Tobias G Boatman, Tracy Lawson, Richard J Geider
Trichodesmium is a globally important marine diazotroph that accounts for approximately 60 - 80% of marine biological N2 fixation and as such plays a key role in marine N and C cycles. We undertook a comprehensive assessment of how the growth rate of Trichodesmium erythraeum IMS101 was directly affected by the combined interactions of temperature, pCO2 and light intensity. Our key findings were: low pCO2 affected the lower temperature tolerance limit (Tmin) but had no effect on the optimum temperature (Topt) at which growth was maximal or the maximum temperature tolerance limit (Tmax); low pCO2 had a greater effect on the thermal niche width than low-light; the effect of pCO2 on growth rate was more pronounced at suboptimal temperatures than at supraoptimal temperatures; temperature and light had a stronger effect on the photosynthetic efficiency (Fv/Fm) than did CO2; and at Topt, the maximum growth rate increased with increasing CO2, but the initial slope of the growth-irradiance curve was not affected by CO2...
2017: PloS One
https://www.readbyqxmd.com/read/28080999/electrochemical-depositing-rgo-ti-rgo-heterogeneous-substrates-with-higher-thermal-conductivity-and-heat-transfer-performance-compared-to-pure-ti
#5
Jing Wang, Huatao Wang, Wenying Zhang, Xinyi Yang, Guangwu Wen, Yijie Wang, Weiwei Zhou
Titanium (Ti) and its alloys are widely applied in many high strength, light weight applications, but their thermal conductivity is lower compared to that of other metals, which limits their further applications. In this paper, we demonstrated experimentally that rGO-Ti-rGO heterogeneous substrates with higher thermal conductivity, up to ∼38.8% higher than Ti, could be fabricated by electrochemical depositing rGO on their surface. The rGO layers are grown on the surface of Ti substrates, with appearance of bedclothes on the beds...
January 12, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28079373/energetics-of-the-s2-state-spin-isomers-of-the-oxygen-evolving-complex-of-photosystem-ii
#6
David J Vinyard, Sahr Khan, Mikhail Askerka, Victor S Batista, Gary W Brudvig
The S2 redox intermediate of the oxygen-evolving complex in Photosystem II is present as two spin isomers. The S = 1/2 isomer gives rise to a multiline EPR signal at g = 2, while the S = 5/2 isomer exhibits a broad EPR signal at g = 4.1. The electronic structures of these isomers are known, but their role in the catalytic cycle of water oxidation remains unclear. We show that formation of the S = 1/2 state from the S = 5/2 state is exergonic at temperatures above 160 K. However, the S = 1/2 isomer decays to S1 more slowly than the S = 5/2 isomer...
January 12, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28078884/construction-of-three-dimensional-hemin-functionalized-graphene-hydrogel-with-high-mechanical-stability-and-adsorption-capacity-for-enhancing-photodegradation-of-methylene-blue
#7
Yuewu Zhao, Yuanjian Zhang, Anran Liu, Zhenzhen Wei, Songqin Liu
A three-dimensional hemin-functionalized graphene hydrogel (Hem/GH) was prepared by a facile self-assembly approach. The as-prepared Hem/GH showed good mechanical strength with a storage modulus of 609-642 kPa and a high adsorption capacity to organic dye contaminants (341 mg g-1 for rhodamine B). Moreover, Hem/GH could be used as photosensitizer for photocatalytic degradation of organic dyes, and showed superior photodegradation activity of methylene blue (MB) with respect to the counterparts such as graphene hydrogel (GH) and commercial catalyst P25...
January 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28077724/trem2-promotes-microglial-survival-by-activating-wnt-%C3%AE-catenin-pathway
#8
Honghua Zheng, Lin Jia, Chia-Chen Liu, Zhouyi Rong Li Zhong, Longyu Yang, Xiao-Fen Chen, John D Fryer, Xin Wang, Yun-Wu Zhang, Huaxi Xu, Guojun Bu
: Triggering Receptor Expressed on Myeloid cells 2 (TREM2), expressed on myeloid cells including microglia in the central nervous system (CNS), has recently been identified as a risk factor for Alzheimer's disease (AD). TREM2 transmits intracellular signals through its trans-membrane binding partner DNAX-activating protein 12 (DAP12). Homozygous mutations inactivating TREM2 or DAP12 lead to Nasu-Hakola disease (NHD); however, how AD risk-conferring variants increase AD risk is not clear...
January 11, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28076377/comparative-analysis-of-vertebrate-diurnal-circadian-transcriptomes
#9
Greg Boyle, Kerstin Richter, Henry D Priest, David Traver, Todd C Mockler, Jeffrey T Chang, Steve A Kay, Ghislain Breton
From photosynthetic bacteria to mammals, the circadian clock evolved to track diurnal rhythms and enable organisms to anticipate daily recurring changes such as temperature and light. It orchestrates a broad spectrum of physiology such as the sleep/wake and eating/fasting cycles. While we have made tremendous advances in our understanding of the molecular details of the circadian clock mechanism and how it is synchronized with the environment, we still have rudimentary knowledge regarding its connection to help regulate diurnal physiology...
2017: PloS One
https://www.readbyqxmd.com/read/28075562/evidence-for-a-di-%C3%A2%C2%B5-oxo-diamond-core-in-the-mn-iv-fe-iv-activation-intermediate-of-ribonucleotide-reductase-from-chlamydia-trachomatis
#10
Ryan J Martinie, Elizabeth J Blaesi, Carsten Krebs, J Martin Bollinger, Alexey Silakov, Christopher J Pollock
High-valent iron and manganese complexes effect some of the most challenging biochemical reactions known, including hydrocarbon and water oxidations associated with the global carbon cycle and oxygenic photosynthesis, respectively. Their extreme reactivity presents an impediment to structural characterization, but their biological importance and potential chemical utility have, nevertheless, motivated extensive efforts toward that end. Several such intermediates accumulate during activation of class I ribonucleotide reductase (RNR) β subunits, which self-assemble dimetal cofactors with stable one-electron oxidants that serve to initiate the enzyme's free-radical mechanism...
January 11, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28074036/redox-crisis-underlies-conditional-light-dark-lethality-in-cyanobacterial-mutants-that-lack-the-circadian-regulator-rpaa
#11
Spencer Diamond, Benjamin E Rubin, Ryan K Shultzaberger, You Chen, Chase D Barber, Susan S Golden
Cyanobacteria evolved a robust circadian clock, which has a profound influence on fitness and metabolism under daily light-dark (LD) cycles. In the model cyanobacterium Synechococcus elongatus PCC 7942, a functional clock is not required for diurnal growth, but mutants defective for the response regulator that mediates transcriptional rhythms in the wild-type, regulator of phycobilisome association A (RpaA), cannot be cultured under LD conditions. We found that rpaA-null mutants are inviable after several hours in the dark and compared the metabolomes of wild-type and rpaA-null strains to identify the source of lethality...
January 10, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28073566/mixotrophy-in-the-phototrophic-dinoflagellate-takayama-helix-family-kareniaceae-predator-of-diverse-toxic-and-harmful-dinoflagellates
#12
Hae Jin Jeong, Jin Hee Ok, An Suk Lim, Ji Eun Kwon, So Jin Kim, Sung Yeon Lee
Takayama spp. are phototrophic dinoflagellates belonging to the family Kareniaceae and have caused fish kills in several countries. Understanding their trophic mode and interactions with co-occurring phytoplankton species are critical steps in comprehending their ecological roles in marine ecosystems, bloom dynamics, and dinoflagellate evolution. To investigate the trophic mode and interactions of Takayama spp., the ability of Takayama helix to feed on diverse algal species was examined, and the mechanisms of prey ingestion were determined...
December 2016: Harmful Algae
https://www.readbyqxmd.com/read/28073541/the-main-nitrate-transporter-of-the-dinoflagellate-lingulodinium-polyedrum-is-constitutively-expressed-and-not-responsible-for-daily-variations-in-nitrate-uptake-rates
#13
Steve Dagenais Bellefeuille, David Morse
Dinoflagellates are unicellular eukaryotes capable of forming spectacular harmful algal blooms (HABs). Eutrophication of coastal waters by fertilizer runoff, nitrate in particular, has contributed to recent increases in the frequency, magnitude and geographic extent of HABs. Although physiological nitrate uptake and assimilation in dinoflagellates have often been measured in the field and in the laboratory, no molecular components involved in nitrate transport have yet been reported. This study reports the first identification and characterization of dinoflagellate nitrate transporters, found in the transcriptome of the bloom-forming Lingulodinium polyedrum...
May 2016: Harmful Algae
https://www.readbyqxmd.com/read/28073508/mixotrophic-ability-of-the-phototrophic-dinoflagellates-alexandrium-andersonii-a-affine-and-a-fraterculus
#14
Kyung Ha Lee, Hae Jin Jeong, Ji Eun Kwon, Hee Chang Kang, Ji Hye Kim, Se Hyeon Jang, Jae Yeon Park, Eun Young Yoon, Jae Seong Kim
The dinoflagellate Alexandrium spp. have received much attention due to their harmful effects on diverse marine organisms, including commercially important species. For minimizing loss due to red tides or blooms of Alexandrium spp., it is very important to understand the eco-physiology of each Alexandrium species and to predict its population dynamics. Its trophic mode (i.e., exclusively autotrophic or mixotrophic) is one of the most critical parameters in establishing prediction models. However, among the 35 Alexandrium species so far described, only six Alexandrium species have been revealed to be mixotrophic...
November 2016: Harmful Algae
https://www.readbyqxmd.com/read/28072861/identification-of-the-molecular-clockwork-of-the-oyster-crassostrea-gigas
#15
Mickael Perrigault, Damien Tran
Molecular clock system constitutes the origin of biological rhythms that allow organisms to anticipate cyclic environmental changes and adapt their behavior and physiology. Components of the molecular clock are largely conserved across a broad range of species but appreciable diversity in clock structure and function is also present especially in invertebrates. The present work aimed at identify and characterize molecular clockwork components in relationship with the monitoring of valve activity behavior in the oyster Crassostrea gigas...
2017: PloS One
https://www.readbyqxmd.com/read/28072840/locomotor-activity-and-body-temperature-patterns-over-a-temperature-gradient-in-the-highveld-mole-rat-cryptomys-hottentotus-pretoriae
#16
Meghan Haupt, Nigel C Bennett, Maria K Oosthuizen
African mole-rats are strictly subterranean mammals that live in extensive burrow systems. High humidity levels in the burrows prevent mole-rats from thermoregulating using evaporative cooling. However, the relatively stable environment of the burrows promotes moderate temperatures and small daily temperature fluctuations. Mole-rats therefore display a relatively wide range of thermoregulation abilities. Some species cannot maintain their body temperatures at a constant level, whereas others employ behavioural thermoregulation...
2017: PloS One
https://www.readbyqxmd.com/read/28071755/variation-in-short-term-and-long-term-responses-of-photosynthesis-and-isoprenoid-mediated-photoprotection-to-soil-water-availability-in-four-douglas-fir-provenances
#17
Laura Verena Junker, Anita Kleiber, Kirstin Jansen, Henning Wildhagen, Moritz Hess, Zachary Kayler, Bernd Kammerer, Jörg-Peter Schnitzler, Jürgen Kreuzwieser, Arthur Gessler, Ingo Ensminger
For long-lived forest tree species, the understanding of intraspecific variation among populations and their response to water availability can reveal their ability to cope with and adapt to climate change. Dissipation of excess excitation energy, mediated by photoprotective isoprenoids, is an important defense mechanism against drought and high light when photosynthesis is hampered. We used 50-year-old Douglas-fir trees of four provenances at two common garden experiments to characterize provenance-specific variation in photosynthesis and photoprotective mechanisms mediated by essential and non-essential isoprenoids in response to soil water availability and solar radiation...
January 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28071671/effect-of-seed-morph-and-light-level-on-growth-and-reproduction-of-the-amphicarpic-plant-amphicarpaea-edgeworthii-fabaceae
#18
Keliang Zhang, Jerry M Baskin, Carol C Baskin, Xuejun Yang, Zhenying Huang
Amphicarpic plants produce aerial and subterranean fruits on an individual plant, and these heteromorphic diaspores give rise to plants that differ in growth and ecology. Amphicarpaea edgeworthii is a summer annual amphicarpic species that grows over a range of light levels. We aimed to compare the response to shading intensity of plants of A. edgeworthii grown throughout their life cycle from aerial seeds (ASP) and from subterranean seeds (SSP). We hypothesized that vegetative and reproductive growth of plants from ASP and SSP respond differently to light...
January 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28071604/anion-exchange-strategy-to-synthesis-of-porous-nis-hexagonal-nanoplates-for-supercapacitors
#19
Zhongchun Li, Xuewei Yu, Aijun Gu, Huang Tang, Liangbiao Wang, Zhengsong Lou
A facile anion exchange strategy was applied to the synthesis of porous NiS hexagonal nanoplates (NiS HNPs) as an electrode material for supercapacitors. It was found that Na2S concentration is a key factor to achieve porous NiS hexagonal nanoplates with well-defined architecture. Porous NiS hexagonal nanoplates exhibited a specific capacitance of 1897 F g(-1) at a current density of 1 A g(-1). NiS HNPs//activated carbon (AC) asymmetric supercapacitor (ASC) shows a long cycle lifespan (about 100% capacity retention after 4000 cycles at a current density of 3 A g(-1)) with a maximum energy density of 11...
January 10, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28071051/supramolecular-platform-with-switchable-multivalent-affinity-photo-reversible-capture-and-release-of-bacteria
#20
Wenjun Zhan, Ting Wei, Limin Cao, Changming Hu, Yangcui Qu, Qian Yu, Hong Chen
Surfaces having dynamic control of interactions at the biological system-material interface are of great scientific and technological interest. In this work, a supramolecular platform with switchable multivalent affinity was developed to efficiently capture bacteria and on-demand release captured bacteria in response to irradiation with light of different wavelengths. The system consists of a photo-responsive self-assembled monolayer containing azobenzene (Azo) groups as guest and β-cyclodextrin (β-CD)-mannose (CD-M) conjugates as host, with each CD-M containing seven mannose units to display localized multivalent carbohydrates...
January 10, 2017: ACS Applied Materials & Interfaces
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