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Laurent gautron

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https://www.readbyqxmd.com/read/27822503/levels-of-cocaine-and-amphetamine-regulated-transcript-in-vagal-afferents-in-the-mouse-are-unaltered-in-response-to-metabolic-challenges
#1
Xuefeng Yuan, Ying Huang, Sarita Shah, Hua Wu, Laurent Gautron
Cocaine- and amphetamine-regulated transcript (CART) is one of the most abundant neuropeptides in vagal afferents, including those involved in regulating feeding. Recent observations indicate that metabolic challenges dramatically alter the neuropeptidergic profile of CART-producing vagal afferents. Here, using confocal microscopy, we reassessed the distribution and regulation of CART(55-102) immunoreactivity in vagal afferents of the male mouse in response to metabolic challenges, including fasting and high-fat-diet feeding...
September 2016: ENeuro
https://www.readbyqxmd.com/read/27409456/modulation-of-defects-in-semiconductors-by-facile-and-controllable-reduction-the-case-of-p-type-cucro2-nanoparticles
#2
Tengfei Jiang, Xueyan Li, Martine Bujoli-Doeuff, Eric Gautron, Laurent Cario, Stéphane Jobic, Romain Gautier
Optical and electrical characteristics of solid materials are well-known to be intimately related to the presence of intrinsic or extrinsic defects. Hence, the control of defects in semiconductors is of great importance to achieve specific properties, for example, transparency and conductivity. Herein, a facile and controllable reduction method for modulating the defects is proposed and used for the case of p-type delafossite CuCrO2 nanoparticles. The optical absorption in the infrared region of the CuCrO2 material can then be fine-tuned via the continuous reduction of nonstoichiometric Cu(II), naturally stabilized in small amounts...
August 1, 2016: Inorganic Chemistry
https://www.readbyqxmd.com/read/27111742/lipopolysacharide-rapidly-and-completely-suppresses-agrp-neuron-mediated-food-intake-in-male-mice
#3
Yang Liu, Ying Huang, Tiemin Liu, Hua Wu, Huxing Cui, Laurent Gautron
Although Agouti-related peptide (AgRP) neurons play a key role in the regulation of food intake, their contribution to the anorexia caused by proinflammatory insults has yet to be identified. Using a combination of neuroanatomical and pharmacogenetics experiments, this study sought to investigate the importance of AgRP neurons and downstream targets in the anorexia caused by the peripheral administration of a moderate dose of lipopolysaccharide (LPS) (100 μg/kg, ip). First, in the C57/Bl6 mouse, we demonstrated that LPS induced c-fos in select AgRP-innervated brain sites involved in feeding but not in any arcuate proopiomelanocortin neurons...
June 2016: Endocrinology
https://www.readbyqxmd.com/read/26420631/corrigendum-unravelling-the-origin-of-the-giant-zn-deficiency-in-wurtzite-type-zno-nanoparticles
#4
Adèle Renaud, Laurent Cario, Xavier Rocquefelte, Philippe Deniard, Eric Gautron, Eric Faulques, Tilak Das, François Cheviré, Franck Tessier, Stéphane Jobic
No abstract text is available yet for this article.
September 30, 2015: Scientific Reports
https://www.readbyqxmd.com/read/26388745/ppar%C3%AE-mrna-in-the-adult-mouse-hypothalamus-distribution-and-regulation-in-response-to-dietary-challenges
#5
Yang Liu, Ying Huang, Syann Lee, Angie L Bookout, Carlos M Castorena, Hua Wu, Laurent Gautron
Peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-activated transcription factor that was originally identified as a regulator of peroxisome proliferation and adipocyte differentiation. Emerging evidence suggests that functional PPARγ signaling also occurs within the hypothalamus. However, the exact distribution and identities of PPARγ-expressing hypothalamic cells remains under debate. The present study systematically mapped PPARγ mRNA expression in the adult mouse brain using in situ hybridization histochemistry...
2015: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/26380935/toward-a-neuroimmunoendocrinology-of-adipose-tissue
#6
COMMENT
Laurent Gautron
No abstract text is available yet for this article.
October 2015: Endocrinology
https://www.readbyqxmd.com/read/26333510/unravelling-the-origin-of-the-giant-zn-deficiency-in-wurtzite-type-zno-nanoparticles
#7
Adèle Renaud, Laurent Cario, Xavier Rocquelfelte, Philippe Deniard, Eric Gautron, Eric Faulques, Tilak Das, François Cheviré, Franck Tessier, Stéphane Jobic
Owing to its high technological importance for optoelectronics, zinc oxide received much attention. In particular, the role of defects on its physical properties has been extensively studied as well as their thermodynamical stability. In particular, a large concentration of Zn vacancies in ZnO bulk materials is so far considered highly unstable. Here we report that the thermal decomposition of zinc peroxide produces wurtzite-type ZnO nanoparticles with an extraordinary large amount of zinc vacancies (>15%)...
2015: Scientific Reports
https://www.readbyqxmd.com/read/26076474/loss-of-the-liver-x-receptor-lxr%C3%AE-%C3%AE-in-peripheral-sensory-neurons-modifies-energy-expenditure
#8
Virginie Mansuy-Aubert, Laurent Gautron, Syann Lee, Angie L Bookout, Christine Kusminski, Kai Sun, Yuan Zhang, Philipp E Scherer, David J Mangelsdorf, Joel K Elmquist
Peripheral neural sensory mechanisms play a crucial role in metabolic regulation but less is known about the mechanisms underlying vagal sensing itself. Recently, we identified an enrichment of liver X receptor alpha and beta (LXRα/β) in the nodose ganglia of the vagus nerve. In this study, we show mice lacking LXRα/β in peripheral sensory neurons have increased energy expenditure and weight loss when fed a Western diet (WD). Our findings suggest that the ability to metabolize and sense cholesterol and/or fatty acids in peripheral neurons is an important requirement for physiological adaptations to WDs...
June 15, 2015: ELife
https://www.readbyqxmd.com/read/25815991/neural-control-of-energy-balance-translating-circuits-to-therapies
#9
REVIEW
Laurent Gautron, Joel K Elmquist, Kevin W Williams
Recent insights into the neural circuits controlling energy balance and glucose homeostasis have rekindled the hope for development of novel treatments for obesity and diabetes. However, many therapies contribute relatively modest beneficial gains with accompanying side effects, and the mechanisms of action for other interventions remain undefined. This Review summarizes current knowledge linking the neural circuits regulating energy and glucose balance with current and potential pharmacotherapeutic and surgical interventions for the treatment of obesity and diabetes...
March 26, 2015: Cell
https://www.readbyqxmd.com/read/25653595/neuroanatomy-and-transgenic-technologies
#10
Alexander C Jackson, Chen Liu, Makoto Fukuda, Michael Lazarus, Laurent Gautron
No abstract text is available yet for this article.
2014: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/24703703/ppar%C3%AE-in-vagal-neurons-regulates-high-fat-diet-induced-thermogenesis
#11
Chen Liu, Angie L Bookout, Syann Lee, Kai Sun, Lin Jia, Charlotte Lee, Swalpa Udit, Yingfeng Deng, Philipp E Scherer, David J Mangelsdorf, Laurent Gautron, Joel K Elmquist
The vagus nerve innervates visceral organs providing a link between key metabolic cues and the CNS. However, it is not clear whether vagal neurons can directly respond to changing lipid levels and whether altered "lipid sensing" by the vagus nerve regulates energy balance. In this study, we systematically profiled the expression of all known nuclear receptors in laser-captured nodose ganglion (NG) neurons. In particular, we found PPARγ expression was reduced by high-fat-diet feeding. Deletion of PPARγ in Phox2b neurons promoted HFD-induced thermogenesis that involved the reprograming of white adipocyte into a brown-like adipocyte cell fate...
April 1, 2014: Cell Metabolism
https://www.readbyqxmd.com/read/23933984/fgf21-regulates-metabolism-and-circadian-behavior-by-acting-on-the-nervous-system
#12
Angie L Bookout, Marleen H M de Groot, Bryn M Owen, Syann Lee, Laurent Gautron, Heather L Lawrence, Xunshan Ding, Joel K Elmquist, Joseph S Takahashi, David J Mangelsdorf, Steven A Kliewer
Fibroblast growth factor 21 (FGF21) is a hepatokine that acts as a global starvation signal to modulate fuel partitioning and metabolism and repress growth; however, the site of action of these diverse effects remains unclear. FGF21 signals through a heteromeric cell-surface receptor composed of one of three FGF receptors (FGFR1c, FGFR2c or FGFR3c) in complex with β-Klotho, a single-pass transmembrane protein that is enriched in metabolic tissues. Here we show that in addition to its known effects on peripheral metabolism, FGF21 increases systemic glucocorticoid levels, suppresses physical activity and alters circadian behavior, which are all features of the adaptive starvation response...
September 2013: Nature Medicine
https://www.readbyqxmd.com/read/23933983/fgf21-contributes-to-neuroendocrine-control-of-female-reproduction
#13
Bryn M Owen, Angie L Bookout, Xunshan Ding, Vicky Y Lin, Stan D Atkin, Laurent Gautron, Steven A Kliewer, David J Mangelsdorf
Preventing reproduction during nutritional deprivation is an adaptive process that is conserved and essential for the survival of species. In mammals, the mechanisms that inhibit fertility during starvation are complex and incompletely understood. Here we show that exposure of female mice to fibroblast growth factor 21 (FGF21), a fasting-induced hepatokine, mimics infertility secondary to starvation. Mechanistically, FGF21 acts on the suprachiasmatic nucleus (SCN) in the hypothalamus to suppress the vasopressin-kisspeptin signaling cascade, thereby inhibiting the proestrus surge in luteinizing hormone...
September 2013: Nature Medicine
https://www.readbyqxmd.com/read/23914153/molecular-anatomy-of-the-gut-brain-axis-revealed-with-transgenic-technologies-implications-in-metabolic-research
#14
Swalpa Udit, Laurent Gautron
Neurons residing in the gut-brain axis remain understudied despite their important role in coordinating metabolic functions. This lack of knowledge is observed, in part, because labeling gut-brain axis neurons and their connections using conventional neuroanatomical methods is inherently challenging. This article summarizes genetic approaches that enable the labeling of distinct populations of gut-brain axis neurons in living laboratory rodents. In particular, we review the respective strengths and limitations of currently available genetic and viral approaches that permit the marking of gut-brain axis neurons without the need for antibodies or conventional neurotropic tracers...
2013: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/23749724/neuronal-and-nonneuronal-cholinergic-structures-in-the-mouse-gastrointestinal-tract-and-spleen
#15
Laurent Gautron, Joseph M Rutkowski, Michael D Burton, Wei Wei, Yihong Wan, Joel K Elmquist
Accumulating evidence demonstrates that acetylcholine can directly modulate immune function in peripheral tissues including the spleen and gastrointestinal tract. However, the anatomical relationships between the peripheral cholinergic system and immune cells located in these lymphoid tissues remain unclear due to inherent technical difficulties with currently available neuroanatomical methods. In this study, mice with specific expression of the tdTomato fluorescent protein in choline acetyltransferase (ChAT)-expressing cells were used to label preganglionic and postganglionic cholinergic neurons and their projections to lymphoid tissues...
November 2013: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/22952883/hindbrain-ghrelin-receptor-signaling-is-sufficient-to-maintain-fasting-glucose
#16
Michael M Scott, Mario Perello, Jen-Chieh Chuang, Ichiro Sakata, Laurent Gautron, Charlotte E Lee, Danielle Lauzon, Joel K Elmquist, Jeffrey M Zigman
The neuronal coordination of metabolic homeostasis requires the integration of hormonal signals with multiple interrelated central neuronal circuits to produce appropriate levels of food intake, energy expenditure and fuel availability. Ghrelin, a peripherally produced peptide hormone, circulates at high concentrations during nutrient scarcity. Ghrelin promotes food intake, an action lost in ghrelin receptor null mice and also helps maintain fasting blood glucose levels, ensuring an adequate supply of nutrients to the central nervous system...
2012: PloS One
https://www.readbyqxmd.com/read/22605619/neuroanatomy-of-melanocortin-4-receptor-pathway-in-the-lateral-hypothalamic-area
#17
Huxing Cui, Jong-Woo Sohn, Laurent Gautron, Hisayuki Funahashi, Kevin W Williams, Joel K Elmquist, Michael Lutter
The central melanocortin system regulates body energy homeostasis including the melanocortin-4 receptor (MC4R). The lateral hypothalamic area (LHA) receives dense melanocortinergic inputs from the arcuate nucleus of the hypothalamus and regulates multiple processes including food intake, reward behaviors, and autonomic function. By using a mouse line in which green fluorescent protein (GFP) is expressed under control of the MC4R gene promoter, we systemically investigated MC4R signaling in the LHA by combining double immunohistochemistry, electrophysiology, and retrograde tracing techniques...
December 15, 2012: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/22592759/melanocortin-4-receptor-expression-in-different-classes-of-spinal-and-vagal-primary-afferent-neurons-in-the-mouse
#18
Laurent Gautron, Charlotte E Lee, Syann Lee, Joel K Elmquist
Melanocortin-4 receptor (MC4R) ligands are known to modulate nociception, but the site of action of MC4R signaling on nociception remains to be elucidated. The current study investigated MC4R expression in dorsal root ganglia (DRG) of the MC4R-GFP reporter mouse. Because MC4R is known to be expressed in vagal afferent neurons in the nodose ganglion (NG), we also systematically compared MC4R-expressing vagal and spinal afferent neurons. Abundant green fluorescent protein (GFP) immunoreactivity was found in about 45% of DRG neuronal profiles (at the mid-thoracic level), the majority being small-sized profiles...
December 1, 2012: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/22541436/a-cardiac-microrna-governs-systemic-energy-homeostasis-by-regulation-of-med13
#19
Chad E Grueter, Eva van Rooij, Brett A Johnson, Susan M DeLeon, Lillian B Sutherland, Xiaoxia Qi, Laurent Gautron, Joel K Elmquist, Rhonda Bassel-Duby, Eric N Olson
Obesity, type 2 diabetes, and heart failure are associated with aberrant cardiac metabolism. We show that the heart regulates systemic energy homeostasis via MED13, a subunit of the Mediator complex, which controls transcription by thyroid hormone and other nuclear hormone receptors. MED13, in turn, is negatively regulated by a heart-specific microRNA, miR-208a. Cardiac-specific overexpression of MED13 or pharmacologic inhibition of miR-208a in mice confers resistance to high-fat diet-induced obesity and improves systemic insulin sensitivity and glucose tolerance...
April 27, 2012: Cell
https://www.readbyqxmd.com/read/22473294/laser-capture-microdissection-and-transcriptional-profiling-of-the-dorsomedial-nucleus-of-the-hypothalamus
#20
Syann Lee, Angie L Bookout, Charlotte E Lee, Laurent Gautron, Matthew J Harper, Carol F Elias, Bradford B Lowell, Joel K Elmquist
Identifying neuronal molecular markers with restricted patterns of expression is a crucial step in dissecting the numerous pathways and functions of the brain. While the dorsomedial nucleus of the hypothalamus (DMH) has been implicated in a host of physiological processes, current functional studies have been limited by the lack of molecular markers specific for DMH. Identification of such markers would facilitate the development of mouse models with DMH-specific genetic manipulations. Here we used a combination of laser-capture microdissection (LCM) and gene expression profiling to identify genes that are highly expressed within the DMH relative to adjacent hypothalamic regions...
November 1, 2012: Journal of Comparative Neurology
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