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https://www.readbyqxmd.com/read/28173930/methodology-for-astronaut-reconditioning-research
#1
David J Beard, Jonathan A Cook
Space medicine offers some unique challenges, especially in terms of research methodology. A specific challenge for astronaut reconditioning involves identification of what aspects of terrestrial research methodology hold and which require modification. This paper reviews this area and presents appropriate solutions where possible. It is concluded that spaceflight rehabilitation research should remain question/problem driven and is broadly similar to the terrestrial equivalent on small populations, such as rare diseases and various sports...
January 2017: Musculoskelet Sci Pract
https://www.readbyqxmd.com/read/28140573/strain-release-heteroatom-functionalization-development-scope-and-stereospecificity
#2
Justin M Lopchuk, Kasper Fjelbye, Yu Kawamata, Lara R Malins, Chung-Mao Pan, Ryan Gianatassio, Jie Wang, Liher Prieto, James Bradow, Thomas A Brandt, Michael R Collins, Jeff Elleraas, Jason Ewanicki, William Farrell, Olugbeminiyi O Fadeyi, Gary M Gallego, James J Mousseau, Robert Oliver, Neal W Sach, Jason K Smith, Jillian E Spangler, Huichin Zhu, Jinjiang Zhu, Phil S Baran
Driven by the ever-increasing pace of drug discovery and the need to push the boundaries of unexplored chemical space, medicinal chemists are routinely turning to unusual strained bioisosteres such as bicyclo[1.1.1]pentane, azetidine, and cyclobutane to modify their lead compounds. Too often, however, the difficulty of installing these fragments surpasses the challenges posed even by the construction of the parent drug scaffold. This full account describes the development and application of a general strategy where spring-loaded, strained C-C and C-N bonds react with amines to allow for the "any-stage" installation of small, strained ring systems...
January 31, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28095962/interview-with-dr-arnold-s-barer-a-soviet-space-medicine-pioneer
#3
Charles R Doarn
No abstract text is available yet for this article.
February 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28068518/impact-of-space-environment-on-stability-of-medicines-challenges-and-prospects
#4
REVIEW
Priti Mehta, Dhara Bhayani
To upkeep health of astronauts in a unique, isolated, and extreme environment of space is the primary goal for a successful space mission, hence, safe and efficacious medications are essential for the wellness of astronauts. Space medication has been challenged with problems related to efficacy. Along with altered physiology, one of the possible reasons could be instability of space medications in the presence of harsh spaceflight environmental conditions. Altered physical and chemical stability can result in reduced potency which can result in reduced efficacy...
March 20, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27994084/ernsting-s-aviation-and-space-medicine
#5
Lachlan Mackay Brown
No abstract text is available yet for this article.
December 2016: Occupational Medicine
https://www.readbyqxmd.com/read/27694600/doctors-in-space-ships-biomedical-uncertainties-and-medical-authority-in-imagined-futures
#6
Lesley Henderson, Simon Carter
There has been considerable interest in images of medicine in popular science fiction and in representations of doctors in television fiction. Surprisingly little attention has been paid to doctors administering space medicine in science fiction. This article redresses this gap. We analyse the evolving figure of 'the doctor' in different popular science fiction television series. Building upon debates within Medical Sociology, Cultural Studies and Media Studies we argue that the figure of 'the doctor' is discursively deployed to act as the moral compass at the centre of the programme narrative...
December 2016: Medical Humanities
https://www.readbyqxmd.com/read/27269583/searching-the-literature-for-proteins-facilitates-the-identification-of-biological-processes-if-advanced-methods-of-analysis-are-linked-a-case-study-on-microgravity-caused-changes-in-cells
#7
Johann Bauer, Markus Bussen, Petra Wise, Markus Wehland, Sabine Schneider, Daniela Grimm
BACKGROUND: More than one hundred reports were published about the characterization of cells from malignant and healthy tissues, as well as of endothelial cells and stem cells exposed to microgravity conditions. METHODS: We retrieved publications about microgravity related studies on each type of cells, extracted the proteins mentioned therein and analyzed them aiming to identify biological processes affected by microgravity culture conditions. RESULTS: The analysis revealed 66 different biological processes, 19 of them were always detected when papers about the four types of cells were analyzed...
July 2016: Expert Review of Proteomics
https://www.readbyqxmd.com/read/27266206/-progress-on-space-oral-medicine-research-under-microgravity-environment
#8
Chen Jing, Cheng Xingqun, Xu Xin, Zhou Xuedong, Li Yuqing
As an interdisciplinary of stomatology and space medicine, space oral medicine focuses mainly on oral diseases happened under space environment. With the manned space technology stepping into the new era, space oral medicine has been put under the spotlight. This article will review the historical events on this subject, summarize the newly progress especially on craniomaxillofacial bone, tooth-derived stem cell and oral microbiology researches and still put forward future prospect.
February 2016: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/27236645/characterization-of-the-mechanical-behavior-of-the-optic-nerve-sheath-and-its-role-in-spaceflight-induced-ophthalmic-changes
#9
Julia Raykin, Taylor E Forte, Roy Wang, Andrew Feola, Brian C Samuels, Jerry G Myers, Lealem Mulugeta, Emily S Nelson, Rudy L Gleason, C Ross Ethier
Visual impairment and intracranial pressure (VIIP) syndrome is characterized by a number of permanent ophthalmic changes, including loss of visual function. It occurs in some astronauts during long-duration spaceflight missions. Thus, understanding the pathophysiology of VIIP is currently a major priority in space medicine research. It is hypothesized that maladaptive remodeling of the optic nerve sheath (ONS), in response to microgravity-induced elevations in intracranial pressure (ICP), contributes to VIIP...
February 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/27005819/impact-of-simulated-microgravity-on-human-bone-stem-cells-new-hints-for-space-medicine
#10
Alessandra Cazzaniga, Jeanette A M Maier, Sara Castiglioni
Bone loss is a well known early event in astronauts and represents one of the major obstacle to space exploration. While an imbalance between osteoblast and osteoclast activity has been described, less is known about the behavior of bone mesenchymal stem cells in microgravity. We simulated microgravity using the Random Positioning Machine and found that mesenchymal stem cells respond to gravitational unloading by upregulating HSP60, HSP70, cyclooxygenase 2 and superoxyde dismutase 2. Such an adaptive response might be involved in inducing the overexpression of some osteogenic transcripts, even though the threshold to induce the formation of bone crystal is not achieved...
April 22, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/26877592/adjunctive-830-nm-light-emitting-diode-therapy-can-improve-the-results-following-aesthetic-procedures
#11
R Glen Calderhead, Won-Serk Kim, Toshio Ohshiro, Mario A Trelles, David B Vasily
BACKGROUND: Aggressive, or even minimally aggressive, aesthetic interventions are almost inevitably followed by such events as discomfort, erythema, edema and hematoma formation which could lengthen patient downtime and represent a major problem to the surgeon. Recently, low level light therapy with light-emitting diodes (LED-LLLT) at 830 nm has attracted attention in wound healing indications for its anti-inflammatory effects and control of erythema, edema and bruising. RATIONALE: The wavelength of 830 nm offers deep penetration into living biological tissue, including bone...
December 30, 2015: Laser Therapy
https://www.readbyqxmd.com/read/26802372/morphing-compression-garments-for-space-medicine-and-extravehicular-activity-using-active-materials
#12
Bradley T Holschuh, Dava J Newman
INTRODUCTION: Compression garments tend to be difficult to don/doff, due to their intentional function of squeezing the wearer. This is especially true for compression garments used for space medicine and for extravehicular activity (EVA). We present an innovative solution to this problem by integrating shape changing materials-NiTi shape memory alloy (SMA) coil actuators formed into modular, 3D-printed cartridges-into compression garments to produce garments capable of constricting on command...
February 2016: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/26561010/spaceflight-effects-on-cytochrome-p450-content-in-mouse-liver
#13
Natalia Moskaleva, Alexander Moysa, Svetlana Novikova, Olga Tikhonova, Victor Zgoda, Alexander Archakov
Hard conditions of long-term manned spaceflight can affect functions of many biological systems including a system of drug metabolism. The cytochrome P450 (CYP) superfamily plays a key role in the drug metabolism. In this study we examined the hepatic content of some P450 isoforms in mice exposed to 30 days of space flight and microgravity. The CYP content was established by the mass-spectrometric method of selected reaction monitoring (SRM). Significant changes in the CYP2C29, CYP2E1 and CYP1A2 contents were detected in mice of the flight group compared to the ground control group...
2015: PloS One
https://www.readbyqxmd.com/read/26454931/-scientific-and-research-experimentation-center-of-aviation-and-space-medicine-and-human-engineeing-celebrates-80th-anniversary
#14
I M Zhdanko, A A Vorona, V V Lapa, M N Khomenko
The article is devoted to the history of the Research Test Center Aviation and Space Medicine and military ergonomics, now included in the Central Research Institute of the Air Force Defense Ministry. The center throughout 80 years history is a leding research organization in the country for the integrated study of the human factor in aviation and problems connected with it. The world-famous scientific schools in aviation physiology, hygiene and radiolorgy, emergency medicine, aviation psychology and ergonomics have been grounded on the basis of this center...
March 2015: Voenno-medit︠s︡inskiĭ Zhurnal
https://www.readbyqxmd.com/read/26210614/-space-medicine-origins-and-current-status-in-m%C3%A3-xico
#15
EDITORIAL
Raúl Carrillo Esper
No abstract text is available yet for this article.
May 2015: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/26102662/8a-03-continuous-monitoring-of-hemodynamics-in-the-short-arm-human-centrifuge-a-feasibility-study
#16
F Londono, B Uytterhaegen, R Kassel, R Vanraemdonck, A Beck, B Comet, A Runge, P Segers
OBJECTIVE: The aim was to test the technical feasibility of a set up combining tonometry and ultrasound, designated as Continuous Physiological and Medical Monitoring (CPMM), for cardiovascular assessment on humans and to evaluate the ability to assess physiological changes induced by artificial gravity in the short arm human centrifuge (SAHC, Verhaert, Belgium) for detecting and preventing potential disorders induced by weightlessness. DESIGN AND METHOD: The project was developed under an European Space Agency (ESA) contract (4000101988/10/NL/EM) and with its support, by the company Verhaert in consortium with the Institute for Space Medicine and Physiology (MEDES) and Ghent University...
June 2015: Journal of Hypertension
https://www.readbyqxmd.com/read/26102144/historical-review-of-lower-body-negative-pressure-research-in-space-medicine
#17
REVIEW
Mark R Campbell, John B Charles
Cephalad redistribution of intravascular and extravascular fluid occurs as a result of weightlessness during spaceflight. This provokes cardiovascular, cardiopulmonary, and autonomic nervous system responses. The resulting altered functional state can result in orthostatic hypotension and intolerance upon landing and return to a gravity environment. In-flight lower body negative pressure (LBNP) transiently restores normal body fluid distribution. Early in the U.S. space program, LBNP was devised as a way to test for orthostatic intolerance...
July 2015: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/26027344/-scientific-and-practical-contribution-of-g-m-zarakovskiy-to-domestic-psychophysiology-development-to-the-90th-anniversary
#18
A A Medenkov
This article presents the main directions and outcomes of G.M. Zarakovskiy researches of psychophysiological characteristics and human capabilities for them accounting in designing and defining the conditions and organization of human operator activity in order to improve the performance and reliability of professional labour. The article contains the main dates of his life and work at the Military Medical Academy, Institute of Aviation and Space Medicine, and in the all-Russian Research Institute of Technical Aesthetics and conceptual views and approaches of G...
March 2015: Fiziologiia Cheloveka
https://www.readbyqxmd.com/read/25928979/-use-of-the-prenosology-approach-for-attaining-the-objectives-of-pilot-medical-expertise
#19
I B Ushakov, T G Simakova, O M Zipa, A G Chernikova, R M Baevskij
Early diagnostics of senior pilots for diseases and conditions undesirable in terms of flight safety is tightly linked with evaluation of risks of their development. Prenosology diagnostics is focused on borderline states that may pass from health to disease (prenosology and premorbidity) and, vice versa, from disease to recovery (postnosology). Regarding health as a vital adaptation reserve, prenosology diagnostics is concerned with the ability of organism to adapt to an environment rather than probability of disease...
2014: Aviakosmicheskaia i Ekologicheskaia Meditsina, Aerospace and Environmental Medicine
https://www.readbyqxmd.com/read/25928977/-developing-the-methodology-of-examining-the-lower-limb-veins-in-cosmonauts-for-the-space-medicine-practice
#20
A R Kotovskaia, G A Fomina, A V Sal'nikov, E N Iarmanova
The article centres on development of a methodology for evaluating the function of lower limb veins of cosmonauts in microgravity. The whys and wherefores of the choice of occlusive plethysmography equipment and procedure are explained. Much place is given to arguments for the requisite body and limb positioning during venous plethysmography pre launch and on return from space flight. To minimize the gravity effect on venous blood flow, the body should be in the level position and the calf aligned with the hydrodynamically indifferent point...
2014: Aviakosmicheskaia i Ekologicheskaia Meditsina, Aerospace and Environmental Medicine
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