Runci Wang, Anvita Singaraju, Kathryne E Marks, Lorien Shakib, Garrett Dunlap, Ifeoluwakiisi Adejoorin, Stinne R Greisen, Lin Chen, Aidan K Tirpack, Carlos Aude, Miriam R Fein, Derrick J Todd, Lindsey MacFarlane, Susan M Goodman, Edward F DiCarlo, Elena M Massarotti, Jeffrey A Sparks, A Helena Jonsson, Michael B Brenner, Michael A Postow, Karmela K Chan, Anne R Bass, Laura T Donlin, Deepak A Rao
Immune checkpoint inhibitor (ICI) therapies used to treat cancer, such as anti-PD-1 antibodies, can induce autoimmune conditions in some individuals. The T cell mechanisms mediating such iatrogenic autoimmunity and their overlap with spontaneous autoimmune diseases remain unclear. Here, we compared T cells from the joints of 20 patients with an inflammatory arthritis induced by ICI therapy (ICI-arthritis) with two archetypal autoimmune arthritides, rheumatoid arthritis (RA) and psoriatic arthritis (PsA). Single-cell transcriptomic and antigen receptor repertoire analyses highlighted clonal expansion of an activated effector CD8 T cell population in the joints and blood of patients with ICI-arthritis...
July 28, 2023: Science Immunology