keyword
https://read.qxmd.com/read/38433519/reducing-cardiovascular-risk-in-immune-mediated-inflammatory-diseases-tumour-necrosis-factor-inhibitors-compared-to-conventional-therapies-a-systematic-review-and-meta-analysis
#1
REVIEW
N Á Galajda, F A Meznerics, P Mátrai, P Fehérvári, A S Lengyel, M V Kolonics, Z Sipos, L V Kemény, D Csupor, P Hegyi, A Bánvölgyi, P Holló
Immune-mediated inflammatory disease (IMID) patients including psoriasis, inflammatory arthritides and bowel diseases have a higher risk of developing cardiovascular (CV) diseases compared to the general population. The increased CV risk may be promoted by tumour necrosis factor (TNF)-α-mediated immunological processes, which are present both in the pathomechanism of IMIDs and atherosclerosis. Our objective was to comprehensively investigate the effect of TNF inhibitors (TNFi) on CV risk compared with conventional therapies in IMIDs...
March 3, 2024: Journal of the European Academy of Dermatology and Venereology: JEADV
https://read.qxmd.com/read/38423678/pyoderma-gangrenosum-diagnostic-criteria-subtypes-systemic-associations-and-workup
#2
REVIEW
Mallory L Zaino, Courtney R Schadt, Jeffrey P Callen, Lafayette G Owen
Pyoderma gangrenosum (PG) is an inflammatory neutrophilic dermatosis with variable clinical features. The classic presentation is an ulceration with an erythematous to violaceous undermined border. Extracutaneous manifestations may occur. Associated systemic diseases include inflammatory bowel disease, inflammatory arthritides, and hematologic disorders. The pathophysiologic mechanism of disease is not completely known but likely related to the cumulative impact of inflammation, immune-mediated neutrophilic dysfunction, and genetic predisposition...
April 2024: Dermatologic Clinics
https://read.qxmd.com/read/38411201/management-of-postinfectious-inflammatory-arthritis
#3
JOURNAL ARTICLE
Hailey Baker, J Kennedy Amaral, Robert T Schoen
PURPOSE OF REVIEW: Postinfectious inflammatory arthritis can result from various pathogens, including bacteria, viruses, fungi, and parasites. Prompt identification and treatment of acute infection is vital, but some cases progress to chronic arthritis despite successful treatment of infection. Postinfectious inflammatory arthritis varies from mild, self-limited arthralgia to severe, refractory arthritis, necessitating ongoing disease-modifying treatment. This review explores the spectrum of postinfectious inflammatory arthritis to provide insights into effective management...
February 22, 2024: Current Opinion in Rheumatology
https://read.qxmd.com/read/38341194/metabolic-and-molecular-imaging-in-inflammatory-arthritis
#4
REVIEW
Rita Noversa de Sousa, Koray Tascilar, Giulia Corte, Armin Atzinger, Ioanna Minopoulou, Sarah Ohrndorf, Maximilian Waldner, Christian Schmidkonz, Torsten Kuwert, Ferdinand Knieling, Arnd Kleyer, Andreas Ramming, Georg Schett, David Simon, Filippo Fagni
It is known that metabolic shifts and tissue remodelling precede the development of visible inflammation and structural organ damage in inflammatory rheumatic diseases such as the inflammatory arthritides. As such, visualising and measuring metabolic tissue activity could be useful to identify biomarkers of disease activity already in a very early phase. Recent advances in imaging have led to the development of so-called 'metabolic imaging' tools that can detect these changes in metabolism in an increasingly accurate manner and non-invasively...
February 9, 2024: RMD Open
https://read.qxmd.com/read/38251565/autoantibody-negative-rheumatoid-arthritis-still-a-challenge-for-the-rheumatologist
#5
REVIEW
Serena Bugatti, Ludovico De Stefano, Saviana Gandolfo, Francesco Ciccia, Carlomaurizio Montecucco
Increased research over the past 30 years has greatly improved the understanding of the pathophysiological mechanisms and clinical aspects of autoantibody-positive rheumatoid arthritis, resulting in improved management and outcomes. In contrast, the subset of rheumatoid arthritis that does not have autoantibodies (such as rheumatoid factor and anti-citrullinated protein autoantibodies) remains less well defined in its pathogenic mechanisms. Autoantibody-negative rheumatoid arthritis continues to pose diagnostic challenges, might respond differently to therapies, and appears to be burdened with different comorbidities and outcomes...
December 2023: Lancet Rheumatology
https://read.qxmd.com/read/38229170/clinician-and-patient-views-on-janus-kinase-inhibitors-in-the-treatment-of-inflammatory-arthritis-a-mixed-methods-study
#6
JOURNAL ARTICLE
Savia de Souza, Ruth Williams, Elena Nikiphorou
BACKGROUND: Janus kinase inhibitors (JAKi) are new targeted synthetic disease-modifying antirheumatic drugs (DMARDs) licenced in the UK to treat rheumatoid and psoriatic arthritides. Unlike currently often prescribed biological DMARDs, they target a different part of the inflammatory pathway and are taken orally. The aim of this study was to explore what UK-based rheumatology clinicians and inflammatory arthritis (IA) patients think about the awareness, prescription and use of JAKi; how they compare with biologics; and how the COVID-19 pandemic has affected how JAKi are viewed and prescribed...
January 17, 2024: BMC rheumatology
https://read.qxmd.com/read/38216608/assessment-of-safety-profile-of-secukinumab-in-real-world-scenario-using-united-states-food-and-drug-administration-adverse-event-reporting-system-database
#7
JOURNAL ARTICLE
Vishnu Eshwar, Ashwin Kamath
Secukinumab is an anti-IL-17 monoclonal antibody approved for treating psoriasis and various arthritides. A comprehensive evaluation of its safety, especially in a real-world setting, is necessary. This study aimed to describe the adverse events (AE) associated with secukinumab use using the United States Food and Drug Administration Adverse Event Reporting System (FAERS) database. FAERS data files containing AE reports from 2015 to 2021 were downloaded for data mining. Primary or secondary suspect medications indicated for psoriasis were identified and analyzed...
January 12, 2024: Scientific Reports
https://read.qxmd.com/read/38056920/hepatitis-b-vaccination-associated-with-low-response-in-patients-with-rheumatic-diseases-treated-with-biologics
#8
JOURNAL ARTICLE
Vasco C Romão, Pedro Ávila-Ribeiro, Maria João Gonçalves, Rita Cruz-Machado, André Bento Guerreiro, Vítor Teixeira, Ana Valido, Joana Silva-Dinis, Elsa Vieira-Sousa, Maria João Saavedra, Ema Sacadura-Leite, Rui Tato Marinho, Joao Fonseca
BACKGROUND: Hepatitis B virus (HBV) vaccination is recommended for non-immunised patients with rheumatic diseases starting biological disease-modifying antirheumatic drugs (bDMARDs). There is some evidence that HBV vaccination is effective in patients under conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs), but it is currently unclear whether this also applies to bDMARDs. OBJECTIVES: To assess the efficacy and safety of HBV vaccination in patients with inflammatory arthritides treated with bDMARDs...
December 6, 2023: RMD Open
https://read.qxmd.com/read/38056374/aam-assessment-instrument-for-disease-activity-in-aamavata-scope-and-challenges
#9
JOURNAL ARTICLE
Shrikant Wagh, Ashwinikumar Raut
Development and validation of instruments based on concepts and clinical features described in Ayurveda is a constructive step towards translational research in Ayurveda. The clinical decisions in traditional medical practices often depend on clinical features. Such attempts from Ayurveda experts also contribute to strengthen an endeavour of integrative medicine. A recently published article in J-AIM on development and validation of Aam Assessment Instrument (AAI) to assess the disease activity in amavata is a landmark study...
December 5, 2023: Journal of Ayurveda and Integrative Medicine
https://read.qxmd.com/read/38030423/-18-f-fdg-pet-ct-in-polymyalgia-rheumatica-an-update-and-future-aspects
#10
REVIEW
Olivier Gheysens, Marie Péan de Ponfilly, Gaetane Nocturne, Raphaële Seror, Florent L Besson, François Jamar
Polymyalgia rheumatica (PMR) is an inflammatory disorder usually diagnosed in patients older than 50 years of age. It is characterized by sudden onset pain and prolonged morning stiffness in the scapular and/or pelvic girdle, sometimes debilitating and accompanied by constitutional symptoms such as weight loss. In approximately 20% of the cases, it is linked to giant cell arteritis (GCAV) representing a disease continuum. The diagnosis is mainly clinical and noninvasive imaging such as ultrasound of joints may be helpful...
November 28, 2023: Seminars in Nuclear Medicine
https://read.qxmd.com/read/37979028/a-model-of-type-ii-collagen-induced-spondylitis-and-arthritis-in-f1-hybrid-male-mice
#11
JOURNAL ARTICLE
J M Liu, J H Zhao, Y Wang, W Liu, X L Zhang, L Yang, L Zhou
In this study, we tested a new model of ankylosing spondylitis in order to determine its histological and radiological features needed to investigate peripheral arthritis, spondylitis, and formation of the new bone tissues. F1 hybrid male mice (BALB/c×DBA/1), a progeny of spondylitis-susceptible BALB/c male mice and rheumatoid arthritis-susceptible DBA/1 female mice, were immunized intraperitoneally with bovine type II collagen (CII) mixed with adjuvant dimethyldioctadecylammonium bromide. Radiological and histological studies were performed at the peak of swelling, redness, and stiffness...
November 18, 2023: Bulletin of Experimental Biology and Medicine
https://read.qxmd.com/read/37904701/covid-associated-arthritis-after-severe-and-non-severe-covid-19-a-systematic-review
#12
REVIEW
Mahsa Zarpoosh, Parsa Amirian
AIM: Since the coronavirus outbreak became a global health emergency in 2020, various immune-based effects, such as inflammatory arthritis (IA), have been recorded. This study aimed to determine the role of COVID-19 severity on post-COVID arthritis. METHODS: We systematically reviewed 95 patients who developed arthritis after severe and non-severe COVID-19 infection by searching the databases, including PubMed, SCOPUS, and EMBASE. We used the term "COVID-associated arthritis" because there was no definite diagnostic method for classifying arthritides after COVID-19 infection, and the diagnosed arthritis types were based on the authors' viewpoints...
October 2023: Immunity, Inflammation and Disease
https://read.qxmd.com/read/37788595/cutaneous-immune-related-phenomena-in-patients-with-inflammatory-arthritides-treated-with-biological-therapies-clinical-and-pathophysiological-considerations
#13
REVIEW
Aliki I Venetsanopoulou, Konstantina Mavridou, Paraskevi V Voulgari, Alexandros A Drosos
In recent years, identifying the pathophysiologic mechanisms underlying autoimmune arthritides and systematic diseases has led to the use of biological drugs. The primary targets of those biological therapies are cytokines, B cells, and co-stimulation molecules. So far, these targeted therapies have shown good clinical improvement and an acceptable toxicity profile. However, by blocking components of an intact immune system, autoimmune phenomena and paradoxical inflammation have emerged, and among them many cutaneous immune-related adverse events (irAEs)...
September 27, 2023: Seminars in Arthritis and Rheumatism
https://read.qxmd.com/read/37776420/adult-cervical-spine-deformity-a-state-of-the-art-review
#14
REVIEW
Brendan Jackson-Fowl, Aaron Hockley, Sara Naessig, Waleed Ahmad, Katherine Pierce, Justin S Smith, Christopher Ames, Christopher Shaffrey, Claudia Bennett-Caso, Tyler K Williamson, Kimberly McFarland, Peter G Passias
Adult cervical deformity is a structural malalignment of the cervical spine that may present with variety of significant symptomatology for patients. There are clear and substantial negative impacts of cervical spine deformity, including the increased burden of pain, limited mobility and functionality, and interference with patients' ability to work and perform everyday tasks. Primary cervical deformities develop as the result of a multitude of different etiologies, changing the normal mechanics and structure of the cervical region...
September 30, 2023: Spine Deformity
https://read.qxmd.com/read/37716750/updates-of-total-ankle-replacement-revision-options-new-generation-total-ankle-replacement-revision-options-stemmed-implants-peri-articular-osteotomies
#15
REVIEW
Vincent G Vacketta, Jacob M Perkins, Christoper F Hyer
Ankle arthritis is a disabling disease pattern resulting in pain and dysfunction ultimately leading to a reduction in quality of life. Unlike more common arthritides of the knee and hip, ankle arthritis is unique in its presentation with an earlier onset of end-stage disease and an etiology, which is most-commonly posttraumatic in nature. Through continued research and design, improvements have continued to be made as newer generation implants are developed. This article discusses the considerations for revision total ankle replacement based on the current revision options and a treatment algorithm developed by the lead author...
October 2023: Clinics in Podiatric Medicine and Surgery
https://read.qxmd.com/read/37572502/impact-of-dual-neutralization-of-tnf-%C3%AE-and-il-1%C3%AE-along-with-gentamicin-treatment-on-the-functions-of-blood-and-splenic-neutrophils-and-its-role-on-improvement-of-s-aureus-induced-septic-arthritis
#16
JOURNAL ARTICLE
Sharmistha Ghosh, Rituparna Ghosh, Ritasha Sawoo, Puja Dutta, Biswadev Bishayi
Researches of recent past years have emphasized potential of antibiotics to improve septic arthritis but as multi-drug resistant strains like MRSA are emerging fast, new alternative therapeutic advances are high in demand. This study aims to figure out the role of neutrophils in regulating inflammatory responses of S. aureus induced septic arthritis while using TNF-α Ab or IL-1β Ab along with antibiotic gentamicin or both in combination. In this study, role of anti-oxidant enzymes were investigated and correlated with generated ROS level...
August 10, 2023: International Immunopharmacology
https://read.qxmd.com/read/37564618/outcome-of-preoperative-asymptomatic-or-minimally-symptomatic-druj-arthritis-after-total-wrist-arthrodesis-a-single-institution-case-series
#17
JOURNAL ARTICLE
Lauren E Dittman, Alexander Y Shin, Peter C Rhee
Background  Concomitant severe radiocarpal (RC) arthritis with asymptomatic or minimally symptomatic distal radioulnar joint (DRUJ) arthritis can be debilitating for patients. Surgical management of these combined arthritides can pose a dilemma for surgeons and patients. The purpose of this study was to evaluate patients with concomitant RC and DRUJ arthritides who underwent only total wrist arthrodesis (TWA) to determine the need for subsequent surgical management of preoperative asymptomatic/minimally symptomatic DRUJ arthritis...
August 2023: Journal of Wrist Surgery
https://read.qxmd.com/read/37506196/clonally-expanded-cd38-hi-cytotoxic-cd8-t-cells-define-the-t-cell-infiltrate-in-checkpoint-inhibitor-associated-arthritis
#18
JOURNAL ARTICLE
Runci Wang, Anvita Singaraju, Kathryne E Marks, Lorien Shakib, Garrett Dunlap, Ifeoluwakiisi Adejoorin, Stinne R Greisen, Lin Chen, Aidan K Tirpack, Carlos Aude, Miriam R Fein, Derrick J Todd, Lindsey MacFarlane, Susan M Goodman, Edward F DiCarlo, Elena M Massarotti, Jeffrey A Sparks, A Helena Jonsson, Michael B Brenner, Michael A Postow, Karmela K Chan, Anne R Bass, Laura T Donlin, Deepak A Rao
Immune checkpoint inhibitor (ICI) therapies used to treat cancer, such as anti-PD-1 antibodies, can induce autoimmune conditions in some individuals. The T cell mechanisms mediating such iatrogenic autoimmunity and their overlap with spontaneous autoimmune diseases remain unclear. Here, we compared T cells from the joints of 20 patients with an inflammatory arthritis induced by ICI therapy (ICI-arthritis) with two archetypal autoimmune arthritides, rheumatoid arthritis (RA) and psoriatic arthritis (PsA). Single-cell transcriptomic and antigen receptor repertoire analyses highlighted clonal expansion of an activated effector CD8 T cell population in the joints and blood of patients with ICI-arthritis...
July 28, 2023: Science Immunology
https://read.qxmd.com/read/37481716/synovial-and-serum-b-cell-signature-of-autoantibody-negative-rheumatoid-arthritis-versus-autoantibody-positive-rheumatoid-arthritis-and-psoriatic-arthritis
#19
JOURNAL ARTICLE
Ludovico De Stefano, Serena Bugatti, Iolanda Mazzucchelli, Silvia Rossi, Blerina Xoxi, Emanuele Bozzalla Cassione, Terenzj Luvaro, Carlomaurizio Montecucco, Antonio Manzo
OBJECTIVES: Autoantibody-negative rheumatoid arthritis (RA) differs from autoantibody-positive RA in several clinical aspects, possibly underpinned by pathogenetic differences. At present, the role of adaptive immune responses in autoantibody-negative RA remains unclear. Here, we investigated the synovial and serum immunophenotype indicative of B-lymphocyte involvement across the spectrum of autoantibody-positive and -negative chronic arthritides. METHODS: Ultrasound-guided synovial biopsies were retrieved from 131 patients: 43 autoantibody-positive RA, 35 autoantibody-negative RA, 25 polyarticular psoriatic arthritis (PsA), 28 oligoarticular PsA...
July 22, 2023: Rheumatology
https://read.qxmd.com/read/37436715/presence-of-periodontal-disease-and-the-incidence-of-inflammatory-arthritides-in-the-general-population-data-from-the-uk-biobank
#20
JOURNAL ARTICLE
Hae-Ryong Yun, Hee Byung Koh, Jung Tak Park, Seung Hyeok Han, Shin-Wook Kang, Tae-Hyun Yoo, Sung Soo Ahn
OBJECTIVES: To investigate the association between periodontal disease and the development of inflammatory arthritides (IA) in the general population. METHODS: In total, 489 125 participants from the UK Biobank without a previous history of rheumatoid arthritis (RA), ankylosing spondylitis (AS), and psoriatic arthritis (PsA) were enrolled. The primary outcome was the incidence of IA, which was a composite of RA, AS, and PsA according to the presence of periodontal disease based on self-reported oral health indicators...
July 12, 2023: Rheumatology
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