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https://www.readbyqxmd.com/read/28748712/association-between-us-features-of-primary-tumor-and-axillary-lymph-node-metastasis-in-patients-with-clinical-t1-t2n0-breast-cancer
#1
Min Sun Bae, Sung Ui Shin, Sung Eun Song, Han Suk Ryu, Wonshik Han, Woo Kyung Moon
Background Most patients with early-stage breast cancer have clinically negative lymph nodes (LNs). However, 15-20% of patients have axillary nodal metastasis based on the sentinel LN biopsy. Purpose To assess whether ultrasound (US) features of a primary tumor are associated with axillary LN metastasis in patients with clinical T1-T2N0 breast cancer. Material and Methods This retrospective study included 138 consecutive patients (median age = 51 years; age range = 27-78 years) who underwent breast surgery with axillary LN evaluation for clinically node-negative T1-T2 breast cancer...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28746978/digital-image-analysis-of-her2-immunohistochemistry-in-gastric-and-oesophageal-adenocarcinoma-a-validation-study-on-biopsies-and-surgical-specimens
#2
Timco Koopman, Geertruida H de Bock, Henk J Buikema, Maria M Smits, Maarten Louwen, Mariska Hage, Alex Lt Imholz, Bert van der Vegt
AIMS: to test the validity of diagnostics incorporating digital image analysis (DIA) for human epidermal growth factor 2 (HER2) immunohistochemistry (IHC) in gastro-oesophageal adenocarcinomas, as an alternative to current standard diagnostics using manual scoring. METHODS AND RESULTS: we included 319 consecutive gastro-oesophageal adenocarcinomas (232 biopsies and 87 surgical specimens). DIA was applied to determine HER2 IHC classification, using both standard breast cancer (BC) and modified gastro-oesophageal cancer (GEC) cutoffs...
July 26, 2017: Histopathology
https://www.readbyqxmd.com/read/28744985/diffuse-dermal-angiomatosis-mimicking-inflammatory-breast-carcinoma
#3
Yiang Hui, Christopher P Elco, Nicole F Heinl, Ana P Lourenco, Doreen L Wiggins, Yihong Wang
Diffuse dermal angiomatosis (DDA) is a rare pathologically distinct subtype of reactive angioendotheliomatosis. In the literature, few biopsy-proven cases involving breast skin have been reported. We present a case of a 49-year-old female who presented with an indurated, erythematous, weeping, puckered and tender lesion with focal ulceration. Mammography demonstrated diffuse cutaneous and trabecular thickening concerning for inflammatory breast carcinoma. A punch biopsy demonstrated findings consistent with DDA...
July 26, 2017: Breast Journal
https://www.readbyqxmd.com/read/28744086/differentiation-of-secondary-involvement-of-the-breast-by-lymphoreticular-malignancy-from-fibroadenoma-using-ultrasound-elastography-a-report-of-two-cases
#4
Eren Abdulkadir, Ertan Gulhan, Sila Ulus
Extramedullary lymphoma infiltration of the breast by lymphoblastic lymphoma is very rare and most cases are of B-cell lineage; T-cell neoplasms represent less than 10% of all breast lymphomas. Here, we report one patient with lymphoblastic lymphoma and one patient with leukemia, who have similar lesions in breasts with different ultrasound elastography findings. Ultrasound-guided tru-cut biopsies were performed and the first lesion was confirmed as lymphoma infiltration and the second as fibroadenoma. In cases of breast mass presence in patients with a history of hematologic malignancies such as lymphoma or leukemia, breast infiltration should be kept in mind...
April 2017: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/28744085/role-of-exponential-apparent-diffusion-coefficient-in-characterizing-breast-lesions-by-3-0-tesla-diffusion-weighted-magnetic-resonance-imaging
#5
Shweta Kothari, Archana Singh, Utpalendu Das, Diptendra K Sarkar, Chhanda Datta, Avijit Hazra
OBJECTIVE: To evaluate the role of exponential apparent diffusion coefficient (ADC) as a tool for differentiating benign and malignant breast lesions. PATIENTS AND METHODS: This prospective observational study included 88 breast lesions in 77 patients (between 18 and 85 years of age) who underwent 3T breast magnetic resonance imaging (MRI) including diffusion-weighted imaging (DWI) using b-values of 0 and 800 s/mm(2) before biopsy. Mean exponential ADC and ADC of benign and malignant lesions obtained from DWI were compared...
April 2017: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/28742702/trends-on-axillary-surgery-in-nondistant-metastatic-breast-cancer-patients-treated-between-2011-and-2015-a-dutch-population-based-study-in-the-acosog-z0011-and-amaros-era
#6
Ingrid G M Poodt, Pauline E R Spronk, Guusje Vugts, Thijs van Dalen, M T F D Vrancken Peeters, Marjolijn L Rots, Anne Kuijer, Grard A P Nieuwenhuijzen, Robert-Jan Schipper
OBJECTIVES: To evaluate patterns of care in axillary surgery for Dutch clinical T1-4N0M0 (cT1-4N0M0) breast cancer patients and to assess the effect of the American College for Surgeons Oncology Group (ACOSOG)-Z0011 and After Mapping of the Axilla: Radiotherapy Or Surgery (AMAROS) trial on axillary surgery patterns in Dutch cT1-2N0M0 sentinel node positive breast cancer patients. BACKGROUND: Since publication of the ACOSOG-Z0011 and AMAROS trial, omitting a completion axillary lymph node dissection (cALND) in sentinel node positive breast cancer patients is proposed in selected patients...
July 24, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28741261/hereditary-breast-cancer-associated-with-cowden-syndrome-related-pten-mutation-with-lhermitte-duclos-disease
#7
Fuyo Kimura, Ai Ueda, Eiichi Sato, Jiro Akimoto, Hiroshi Kaise, Kimito Yamada, Mari Hosonaga, Yuko Kawai, Saeko Teraoka, Miki Okazaki, Takashi Ishikawa
BACKGROUND: Cowden syndrome is characterized by multiple hamartomas in various tissues, including the skin, brain, breast, thyroid, mucous membrane, and gastrointestinal tract, and is reported to increase the risk of malignant disease. CASE PRESENTATION: We describe the case of a 52-year-old woman in whom a tumor was diagnosed in the left cerebellar hemisphere and treated by surgical resection. Phosphatase and tensin homolog (PTEN) mutation in exon 8 insertion was found in the brain tumor tissue and leukocytes...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28740962/the-effect-of-corticosteroid-treatment-on-bilateral-idiopathic-granulomatous-mastitis
#8
Fatih Çiftci, İbrahim Abdurrahman, Zeynep Tatar
Idiopathic granulomatous mastitis (IGM) is the commonly encountered form of granulomatous mastitis that may result into repetitive infections and/or abscess formation. Mastitis may develop secondary to a systemic disorder such as tuberculosis, diabetes mellitus, or rheumatoid arthritis, or it may develop as an idiopathic disorder. Idiopathic granulomatous mastitis is the most frequent form of all granulomatous diseases affecting the breast. This disorder frequently presents as painful and fast-growing mass in the breast...
2017: Turk J Surg
https://www.readbyqxmd.com/read/28740447/breast-dynamic-contrast-enhanced-mri-fibrocystic-changes-presenting-as-a-non-mass-enhancement-mimicking-malignancy
#9
Zorica C Milosevic, Mirjan M Nadrljanski, Zorka M Milovanovic, Nina Z Gusic, Slavko S Vucicevic, Olga S Radulovic
BACKGROUND: We aimed to analyse the morphokinetic features of breast fibrocystic changes (nonproliferative lesions, proliferative lesions without atypia and proliferative lesions with atypia) presenting as a non-mass enhancement (NME)in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) examination. PATIENTS AND METHODS: Forty-six patients with histologically proven fibrocystic changes (FCCs) were retrospectively reviewed, according to Breast Imaging Reporting and Data System (BI-RADS) lexicon...
June 2017: Radiology and Oncology
https://www.readbyqxmd.com/read/28739767/predictors-of-malignancy-for-female-patients-with-suspicious-nipple-discharge-a-retrospective-study
#10
Liang Jin, Liling Zhu, Shunrong Li, Yinduo Zeng, Lin Haixiong, Fengxi Su, Kai Chen
BACKGROUND: Suspicious nipple discharge (ND) in females requires further treatment, including biopsy or selective duct excision. It is important to identify predictors of malignancy in female patients with suspicious ND. MATERIALS AND METHODS: This retrospective study included patients with suspicious ND who underwent surgical treatment at our center between January 2007 and December 2014. Clinicopathological features were compared between patients with and without malignancy...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28739748/application-of-localization-and-needle-placement-guided-by-mammographic-ultrasound-and-fiberoptic-ductoscopy-for-resection-of-non-palpable-breast-lesions
#11
Zhu Yuan, Xiang Qu, Zhong-Tao Zhang, Wen G Jiang
AIM: To evaluate the usefulness of localization needles under mammographic, ultrasound or fiberoptic ductoscopy guidance for non-palpable breast lesions. PATIENTS AND METHODS: Eighty-three patients undergoing needle localization and biopsy of non-palpable breast lesions under mammographic, ultrasound or fiberoptic ductoscopy guidance from June 2013 to December 2014 in Beijing Friendship Hospital were included in the study. The preoperative imaging assessment, application of localization needles, surgical operation and pathological examination were recorded and analyzed retrospectively...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28739702/anastrozole-induced-autoimmune-hepatitis-a-rare-complication-of-breast-cancer-therapy
#12
Oleksandra Klapko, Elie Ghoulam, Shriram Jakate, Sheila Eswaran, Lydia Usha
BACKGROUND: Autoimmune hepatitis (AIH) is an extremely rare complication of anastrozole therapy. It presents with elevated liver function tests. The diagnosis is established by detecting high titers of autoantibodies such as antinuclear antibodies, anti-smooth muscle antibodies, and elevated immunoglobulins. It is confirmed with a liver biopsy showing interface rosetting and an increased number of plasma cells. Early diagnosis of anastrozole-induced AIH is important because it allows anastrozole to be discontinued and immunomodulatory treatment to be promptly initiated...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28739193/intraocular-metastasis-comparison-of-clinical-presentation-with-a-known-and-unknown-primary-tumour
#13
R Ramoa, M A Saornil, C García-Alvarez, P Diezhandino, P Alonso-Martínez, E García-Lagarto, M F Muñoz-Moreno, F Lopez-Lara
OBJECTIVE: The purpose of the present study is to review the frequency of intraocular metastases as first presentation of systemic disease, and to identify clinical and tumour characteristics. METHODS: Retrospective study of consecutive cases diagnosed of intraocular metástasis at a referral intraocular tumours unit between 1993 and 2014. General, epidemiological and ophthalmological characteristics were recorded. RESULTS: A total of 21 patients, with a mean age 62...
July 21, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/28739122/idiopathic-granulomatous-mastitis-a-diagnostic-and-therapeutic-challenge
#14
C M Freeman, B T Xia, G C Wilson, J D Lewis, S Khan, S J Lee, E E Lower, M J Edwards, E A Shaughnessy
BACKGROUND: Idiopathic granulomatous mastitis is a rare benign breast disease of women of reproductive age. It usually presents as a painful mass. Since the etiology is unclear, directed diagnosis and management is lacking. METHODS: This is a retrospective chart review of 14 patients, over twelve years (2004-2016), identified through query of pathology findings. RESULTS: Two asymptomatic patients were diagnosed after oncologic breast resection following neoadjuvant chemotherapy...
July 8, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28738381/cytological-criteria-to-distinguish-phyllodes-tumour-of-the-breast-from-fibroadenoma
#15
Robert M Maritz, Pamela M Michelow
OBJECTIVE: To determine whether there are significant differences between fibroadenomas and phyllodes tumours with regard to selected cytomorphological features. STUDY DESIGN: A 10-year retrospective review was performed of patients who underwent excision of a fibroadenoma or phyllodes tumour and in whom a preoperative fine-needle aspiration was performed. The following cytological criteria were assessed: number of stromal and epithelial fragments, stromal-to-epithelial ratio, stromal cellularity, stromal borders, stromal atypia, and proportion of background wavy spindled cells...
July 25, 2017: Acta Cytologica
https://www.readbyqxmd.com/read/28736191/clinical-histological-and-ultrasound-follow-up-of-breast-reconstruction-with-one-stage-muscle-sparing-wrap-technique-a-single-center-experience
#16
Maria Giuseppina Onesti, Michele Maruccia, Giuseppe Di Taranto, Antonio Albano, Giuseppe Soda, Laura Ballesio, Nicolò Scuderi
BACKGROUND: Prepectoral implant placement and complete coverage with porcine acellular matrix after mastectomy is a new concept in breast surgery presented in few cases in the literature. This paper aimed to present our single-center experience in one-stage breast reconstruction muscle-sparing "wrap" technique by evaluating clinical and aesthetic outcomes, ultrasound and histological examination, and patient quality of life. METHODS: From January 2014 to January 2017, 52 patients (40 unilateral, 12 bilateral) underwent one-stage muscle-sparing breast reconstructions with Braxon(®) acellular dermal matrix and implant...
June 29, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28735457/impact-of-sentinel-lymph-node-biopsy-by-ultrasound-guided-core-needle-biopsy-for-patients-with-suspicious-node-positive-breast-cancer
#17
Rikiya Nakamura, Naohito Yamamoto, Toshiko Miyaki, Makiko Itami, Nobumitsu Shina, Masayuki Ohtsuka
PURPOSE: The purpose of this study was to investigate the accuracy of preoperative diagnostic tools for axillary lymph nodes (LNs) staging of breast cancer. MATERIALS AND METHODS: A total of 2464 consecutive patients with operable breast cancer were prospectively identified at our institution between April 2012 and March 2017. Patients with suspicious axillary LN of breast cancer were assessed using preoperative ultrasound(US) or computed tomography (CT), underwent fine-needle aspiration cytology (FNA) or core needle biopsy (CNB)...
July 22, 2017: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/28735069/surgical-versus-non-surgical-approach-in-primary-desmoid-type-fibromatosis-patients-a-nationwide-prospective-cohort-from-the-french-sarcoma-group
#18
Nicolas Penel, Axel Le Cesne, Sylvie Bonvalot, Antoine Giraud, Emmanuelle Bompas, Maria Rios, Sébastien Salas, Nicolas Isambert, Pascaline Boudou-Rouquette, Charles Honore, Antoine Italiano, Isabelle Ray-Coquard, Sophie Piperno-Neumann, François Gouin, François Bertucci, Thomas Ryckewaert, Jean-Emmanuel Kurtz, Françoise Ducimetiere, Jean-Michel Coindre, Jean-Yves Blay
PURPOSE: The outcome of desmoid-type fibromatosis (DTF) is unpredictable. Currently, a wait-and-see approach tends to replace large en bloc resection as the first therapeutic approach. Nevertheless, there are no validated factors to guide the treatment choice. METHOD: We conducted a prospective study of 771 confirmed cases of DTF. We analysed event-free survival (EFS) based on the occurrence of relapse after surgery, progressive disease during the wait-and-see approach, or change in therapeutic strategy...
July 20, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28734185/primary-small-cell-neuroendocrine-carcinoma-of-the-breast-a-case-report-and-review-of-the-literature
#19
Abigail Tremelling, Selyne Samuel, Mary Murray
INTRODUCTION: Primary small cell neuroendocrine carcinoma of the breast (SCNCB) is a very uncommon type of breast cancer. Histology and morphology are virtually indistinguishable from small cell neuroendocrine carcinomas of the lung (SCNCL), mandating a search for a primary site elsewhere in the body. There is no standard approach to treatment as there are only a limited number of cases reported in the literature. This report summarizes a case of primary SCNCB and presents a review of the literature...
July 8, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28733706/phage-display-selection-in-vitro-characterization-and-correlative-pet-imaging-of-a-novel-her3-peptide
#20
Benjamin M Larimer, Nicholas Phelan, Eric Wehrenberg-Klee, Umar Mahmood
PURPOSE: HER3 (ERBB3) is a receptor tyrosine kinase that is implicated in treatment resistance across multiple cancers, including those of the breast, lung, and prostate. Overexpression of HER3 following targeted therapy can occur rapidly and heterogeneously both within a single lesion and across sites of metastasis, making protein quantification by biopsy highly challenging. A global, non-invasive methodology such as positron emission tomography (PET) imaging can permit serial quantification of HER3, providing a useful approach to monitor HER3 expression across the entire tumor burden both prior to and following treatment...
July 21, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
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