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https://www.readbyqxmd.com/read/29667115/biopsy-feasibility-trial-for-breast-cancer-pathologic-complete-response-detection-after-neoadjuvant-chemotherapy-imaging-assessment-and-correlation-endpoints
#1
Gaiane M Rauch, Henry M Kuerer, Beatriz Adrada, Lumarie Santiago, Tanya Moseley, Rosalind P Candelaria, Elsa Arribas, Jia Sun, Jessica W T Leung, Savitri Krishnamurthy, Wei T Yang
PURPOSE: This study was designed to present the secondary imaging endpoints of the trial for evaluating mammogram (MMG), ultrasound (US) and image guided biopsy (IGBx) assessment of pathologic complete response (pCR) in breast cancer (BC) patients undergoing neoadjuvant chemotherapy (NAC). METHODS: Patients with T1-3, N0-3, M0 triple-negative or HER2-positive BC who received NAC were enrolled in an Institutional Review Board-approved prospective, clinical trial...
April 17, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29666097/natural-history-of-luminal-a-breast-invasive-ductal-carcinoma-in-an-elderly
#2
Geok Hoon Lim, Samantha Piao Xue Tay, Mihir Gudi
An elderly woman, with no clinically palpable breast lump, presented with an initially benign-appearing lesion on ultrasound. She was followed up to reveal the natural history of luminal A breast cancer.
April 17, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29665100/accuracy-of-ultrasound-for-preoperative-assessment-of-tumor-size-in-patients-with-newly-diagnosed-breast-cancer-is-it-affected-by-the-background-parenchymal-echotexture
#3
Kyung Hee Ko, Eun Ju Son, In Wha Kim
OBJECTIVES: To assess the impact of the background parenchymal echotexture on the accuracy of tumor size estimation using breast ultrasound (US). METHODS: A total of 140 women with newly diagnosed invasive breast cancer from January 2014 to December 2015 were enrolled in this study. Two radiologists retrospectively reviewed US images in consensus for background parenchymal echotexture interpretation. The maximum tumor diameter from static images was recorded. Tumor size measurements were considered as having agreement with histologic results if they were within ±5 mm compared to the pathologic size...
April 17, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29664831/design-of-mini-latissimus-dorsi-flap-based-on-thoracodorsal-vascular-patterns
#4
Ehab Mostafa Elzawawy, Melad Naim Kelada, Ahmed Farouk Al Karmouty
INTRODUCTION: Latissimus dorsi (LD) flap has been used for reconstructive purposes in oncoplastic breast surgery. Using large part of the muscle as a flap leads to a residual functional loss. Muscle sparing and mini LD flaps can be used with no functional sequelae. However, the design of such flap presents a challenge. METHODS: Twenty cadavers were dissected on both sides to identify the different vascular patterns of the thoracodorsal (TD) pedicle. The vessels were counted, and the following measurements were taken: diameter, length, distance from inferior angel of scapula, and vertebral level...
April 17, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29661602/automated-breast-ultrasound-interpretation-times-a-reader-performance-study
#5
Ashley I Huppe, Marc F Inciardi, Mark Redick, Melissa Carroll, Jennifer Buckley, Jacqueline D Hill, Jason B Gatewood
RATIONALE AND OBJECTIVES: This study aimed to determine the average time for breast radiologists of varied experience to interpret automated breast ultrasound (ABUS) examinations. MATERIALS AND METHODS: A reader performance study was conducted on female patients, with ACR BI-RADS 4 breast density classifications of C or D, who received both an ABUS screening examination and a digital mammogram from 2013 to 2014 at an academic institution. Three faculty breast radiologists with varied levels of ABUS experience (advanced, intermediate, novice) read all ABUS examinations, with interpretation times and final impressions (categorized as "normal" or "abnormal") recorded for each examination...
April 13, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29661546/strategy-for-the-accurate-preoperative-evaluation-of-the-number-of-metastatic-axillary-lymph-nodes-in-breast-cancer
#6
Nao Imai, Mika Kitayama, Akiko Shibahara, Yuri Bessho, Mai Shibusawa, Aya Noro, Keiko Inakami, Noriko Hanamura, Hiroshi Imai, Tomoko Ogawa
BACKGROUND: After the ACOSOG Z0011 trial, it became important to evaluate the number of metastatic axillary lymph nodes (LNs) preoperatively. The purpose of this paper is to confirm whether the number of metastases can be accurately diagnosed by preoperative computed tomography (CT), ultrasound sonography (US), and US-guided fine-needle aspiration cytology (FNAC). METHODS: We retrospectively analyzed the axillary LNs finding of preoperative CT/US of 470 breast cancer patients...
April 13, 2018: Asian Journal of Surgery
https://www.readbyqxmd.com/read/29660916/comparison-of-strain-and-acoustic-radiation-force-impulse-elastography-of-breast-lesions-by-qualitative-evaluation
#7
Qing Zhao, Xiao-Lei Wang, Jia-Wei Sun, Zhao-Peng Jiang, Lin Tao, Xian-Li Zhou
OBJECTIVES: To compare the diagnostic performance of conventional strain elastography (CSE) and acoustic radiation force impulse (ARFI) induced SE for qualitative assessment of breast lesions and evaluate the additional value of the two techniques combined with Breast Imaging Reporting and Data System (BI-RADS) respectively for the differentiation of benign and malignant breast lesions. METHODS: In a cohort of 110 women, the conventional ultrasound (US) features and the elasticity scores of CSE and ARFI induced SE were recorded...
April 13, 2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29660908/evaluation-of-shear-wave-elastography-for-differential-diagnosis-of-breast-lesions-a-new-qualitative-analysis-versus-conventional-quantitative-analysis
#8
Wei-Wei Ren, Xiao-Long Li, Dan Wang, Bo-Ji Liu, Chong-Ke Zhao, Hui-Xiong Xu
OBJECTIVE: To evaluate a special kind of ultrasound (US) shear wave elastography for differential diagnosis of breast lesions, using a new qualitative analysis (i.e. the elasticity score in the travel time map) compared with conventional quantitative analysis. METHODS: From June 2014 to July 2015, 266 pathologically proven breast lesions were enrolled in this study. The maximum, mean, median, minimum, and standard deviation of shear wave speed (SWS) values (m/s) were assessed...
April 13, 2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29660903/complex-cystic-and-solid-breast-lesions-diagnostic-performance-of-conventional-ultrasound-strain-imaging-and-point-shear-wave-speed-measurement
#9
Ying Zhang, Hui-Xiong Xu, Chong-Ke Zhao, Xiao-Long Li, Xiao-Wan Bo, Ya-Ping He, Bo-Ji Liu, Dan Wang, Wei-Wei Ren
OBJECTIVE: To assess the performance of conventional high frequency ultrasound (US) and US elastography in diagnosis of complex cystic and solid breast lesions. METHODS: Ninety three lesions in 93 patients underwent conventional US and US elastography, including strain elastography, acoustic radiation force impulse (ARFI) imaging, and point shear wave speed (SWS) measurement. RESULTS: Pathological examination revealed 31 (33.3%) of the 93 lesions were malignant and the remaining 62 (66...
April 13, 2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29658793/growing-bi-rads-category-3-lesions-on-follow-up-breast-ultrasound-malignancy-rates-and-worrisome-features
#10
Su Min Ha, Eun Young Chae, Joo Hee Cha, Hee Jung Shin, Woo Jung Choi, Hak Hee Kim
OBJECTIVE: To determine the frequency and malignancy rate among growing Breast Imaging Reporting and Data System (BI-RADS) category 3 lesions diagnosed on follow-up breast ultrasound (US) and to evaluate the radiological and clinical features associated with malignancy. METHODS: Of the 38,482 women who underwent breast US between January 2010 and December 2011, 11,582 (30.1%) patients had 12,514 BI-RADS category 3 lesions. Patients whose lesions showed ≥20% enlargement on follow-up US were selected for this study...
April 16, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29658786/imaging-findings-of-mammary-and-systemic-silicone-deposition-secondary-to-breast-implants
#11
Naziya Samreen, Katrina N Glazebrook, Asha Bhatt, Sudhakar K Venkatesh, Brendan P McMenomy, Anupam Chandra, Shuai Ieng, Kalie E Adler, Cynthia H McCollough
In patients with silicone breast implants, implant rupture can occur, which can be intracapsular or extracapsular. Following implant rupture, silicone can travel through the lymphatic system into regional and distant lymph nodes. The purpose of this pictorial essay is to present findings of silicone implant rupture with intramammary and systemic silicone deposition as seen on dual energy CT (DECT), US, mammogram, PET/CT and MRI. We include imaging findings of silicone deposition in the breast in cases of intracapsular and extracapsular rupture...
April 16, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29656881/fundamentals-of-functional-imaging-i-current-clinical-techniques
#12
A Luna, T Martín Noguerol, L Alcalá Mata
Imaging techniques can establish a structural, physiological, and molecular phenotype for cancer, which helps enable accurate diagnosis and personalized treatment. In recent years, various imaging techniques that make it possible to study the functional characteristics of tumors quantitatively and reproducibly have been introduced and have become established in routine clinical practice. Perfusion studies enable us to estimate the microcirculation as well as tumor angiogenesis and permeability using ultrafast dynamic acquisitions with ultrasound, computed tomography, or magnetic resonance (MR) imaging...
April 12, 2018: Radiología
https://www.readbyqxmd.com/read/29656388/preliminary-results-of-acoustic-radiation-force-impulse-imaging-by-combined-qualitative-and-quantitative-analyses-for-evaluation-of-breast-lesions
#13
Lin Wang, Cai-Feng Wan, Jing Du, Feng-Hua Li
OBJECTIVES: The purpose of this study was to evaluate the application of a new elastographic technique, acoustic radiation force impulse (ARFI) imaging, and its diagnostic performance for characterizing breast lesions. METHODS: One hundred consecutive female patients with 126 breast lesions were enrolled in our study. After routine breast ultrasound examinations, the patients underwent ARFI elasticity imaging. Virtual Touch tissue imaging (VTI) and Virtual Touch tissue quantification (Siemens Medical Solutions, Mountain View, CA) were used to qualitatively and quantitatively analyze the elasticity and hardness of tumors...
April 15, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29653288/ph-protective-y-1-receptor-ligand-functionalized-antiphagocytosis-bplp-wpu-micelles-for-enhanced-tumor-imaging-and-therapy-with-prolonged-survival-time
#14
Zhenqi Jiang, Yuchen Tian, Dingying Shan, Yinjie Wang, Ethan Gerhard, Jianbi Xia, Rong Huang, Yan He, Aiguo Li, Jianchao Tang, Huimin Ruan, Yong Li, Juan Li, Jian Yang, Aiguo Wu
Nanoparticle-based tumor therapies are extensively studied; however, few are capable of improving patient survival time due to premature drug leakage, off target effects, and poor tissue penetration. Previously, we successfully synthesized a novel family of Y1 receptor (Y1 R) ligand modified, photoluminescent BPLP nanobubbles and nanoparticles for targeted breast cancer ultrasound imaging; however, increased accumulation could also be observed in the liver, kidney, and spleen, suggesting significant interaction of the particles with macrophages in vivo...
April 4, 2018: Biomaterials
https://www.readbyqxmd.com/read/29650929/-a-case-of-her2-positive-occult-breast-cancer-presenting-as-swollen-axillary-lymphnodes
#15
Toshiyuki Ishiba, Goshi Oda, Tsuyoshi Nakagawa, Takumi Akashi, Yamato Yamashita, Tomoki Aburatani, Taichi Ogo, Yutaka Nakashima, Hironobu Baba, Naoaki Hoshino, Yoshinobu Nishioka, Tatsuyuki Kawano
Occult breast cancer, which develops as a metastatic lesion with no primary tumor detected in the breast, is a rare breast cancer. A 68-year-old female patient particularly complained of the presence of a right axillary mass. The mass in the right axilla was palpable, but no tumor was found in both the breasts on palpation, ultrasound examination, or MRI. Partial breast resection and axillary lymph node dissection were performed following a diagnosis of invasive ductal carcinoma by core needle biopsy. There was no mammary gland tissue present around the tumor due to the pathology of the disease, and the tumor was diagnosed as occult breast cancer...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650314/a-topo-graph-model-for-indistinct-target-boundary-definition-from-anatomical-images
#16
Hui Cui, Xiuying Wang, Jianlong Zhou, Guanzhong Gong, Stefan Eberl, Yong Yin, Lisheng Wang, Dagan Feng, Michael Fulham
BACKGROUND AND OBJECTIVE: It can be challenging to delineate the target object in anatomical imaging when the object boundaries are difficult to discern due to the low contrast or overlapping intensity distributions from adjacent tissues. METHODS: We propose a topo-graph model to address this issue. The first step is to extract a topographic representation that reflects multiple levels of topographic information in an input image. We then define two types of node connections - nesting branches (NBs) and geodesic edges (GEs)...
June 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29644867/ultrasonically-controlled-estrone-modified-liposomes-for-estrogen-positive-breast-cancer-therapy
#17
Najla M Salkho, Vinod Paul, Pierre Kawak, Rute F Vitor, Ana M Martins, Mohammad Al Sayah, Ghaleb A Husseini
A new modality of drug targeting to tumors has been proposed. The ligand-mediated approach, that already increases the therapeutic index of the drug, can still be optimized by the encapsulation of the drug into sonosensitive nanoparticles. In this work, an endogenous ligand, estrone, was used to synthesize doxorubicin-encapsulating liposomes for estrogen receptor (ER)-positive breast cancer therapy with cyanuric chloride (2,4,6 trichloro-1,3,5 triazine) being used as a linking molecule to attach 3-OH group of estrone to the surface of liposomes...
April 12, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29644453/analysis-of-factors-predicting-surgical-intervention-and-associated-costs-in-pediatric-breast-masses-a-single-center-study
#18
E Graham Englert, Guillermo Ares, Andrea Henricks, Karen Rychlik, Catherine J Hunter
PURPOSE: Finding a breast mass in a child provokes apprehension in parents, especially in those with a family history of breast cancer. Clinicians must decide between serial imaging or biopsy of the mass. Herein, we identify management differences in those with and without a positive family history, as well as identify cost differences. METHODS: An institutional retrospective review was performed of patients (2-18 years of age) with a diagnosis of breast mass...
April 11, 2018: Pediatric Surgery International
https://www.readbyqxmd.com/read/29643620/opioid-free-anesthesia-for-breast-cancer-surgery-an-observational-study
#19
Swagata Tripathy, Satyajit Rath, Suresh Agrawal, P Bhaskar Rao, A Panda, T S Mishra, Sukdev Nayak
Background and Aims: Opioids are associated with postoperative nausea, vomiting, drowsiness, and increased analgesic requirement. A nonopioid anesthesia technique may reduce morbidity, enable day care surgery, and possibly decrease tumor recurrence. We compared opioid-free, nerve block-based anesthesia with opioid-based general anesthesia for breast cancer surgery in a prospective cohort study. Material and Methods: Twenty four adult American Society of Anesthesiologists grade I-III patients posted for modified radical mastectomy (MRM) with axillary dissection were induced with propofol and maintained on isoflurane (0...
January 2018: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/29643136/orbital-metastasis-from-an-occult-breast-carcinoma-t0-n1-m1
#20
Rita Pinto Proença, Júlia Fernandes, Miguel N Burnier, Rui Proença
The authors report a case of an orbital metastasis from an occult breast carcinoma. A 66-year-old woman presented with a growing left orbital tumour. Orbital CT scan was consistent with lymphoma. However, ocular pathology revealed small neoplastic cells showing an 'indian file pattern' suggestive of metastatic carcinoma and immunohistochemistry was positive for CK7, CK CAM5.2 and oestrogen receptor. A systemic evaluation was then performed with mammogram, breast ultrasound and MRI considered normal. An exhaustive systemic evaluation revealed multiple bone lesions, a right axillary lymph node lesion, which presented the same pattern on pathology and immunohistochemistry, with no evidence of a primary tumour...
April 11, 2018: BMJ Case Reports
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