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Resveratrol AND Mitochondria

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https://www.readbyqxmd.com/read/28435473/downregulation-of-mitochondrial-cyclooxygenase-2-inhibits-the-stemness-of-nasopharyngeal-carcinoma-by-decreasing-the-activity-of-dynamin-related-protein-1
#1
Teng-Jian Zhou, Shi-Li Zhang, Cheng-Yong He, Qun-Ying Zhuang, Pei-Yu Han, Sheng-Wei Jiang, Huan Yao, Yi-Jun Huang, Wen-Hua Ling, Yu-Chun Lin, Zhong-Ning Lin
Cancer stem cells (CSCs) are a small subset of malignant cells, possessing stemness, with strong tumorigenic capability, conferring resistance to therapy and leading to the relapse of nasopharyngeal carcinoma (NPC). Our previous study suggested that cyclooxygenase-2 (COX-2) would be a novel target for the CSCs-like side population (SP) cells in NPC. In the present study, we further found that COX-2 maintained the stemness of NPC by enhancing the activity of mitochondrial dynamin-related protein 1 (Drp1), a mitochondrial fission mediator, by studying both sorted SP cells from NPC cell lines and gene expression analyses in NPC tissues...
2017: Theranostics
https://www.readbyqxmd.com/read/28434671/resveratrol-improves-mitochondrial-function-in-the-remnant-kidney-from-5-6-nephrectomized-rats
#2
Yan Hui, Miaomiao Lu, Yarong Han, Hongli Zhou, Wei Liu, Lijing Li, Ruixia Jin
Mitochondrial dysfunction is involved in the pathogenesis of chronic kidney disease (CKD). Resveratrol has been demonstrated to be beneficial for the recovery of kidney diseases. In this study, the 5/6 nephrectomized rat was used as a CKD model and the TGF-β1-exposed mouse mesangial cells were used as an in vitro model. Pathological examination showed that resveratrol treatment attenuated glomerular injury in the remnant kidney of 5/6 nephrectomized rat. Additionally, resveratrol improved mitochondrial function in vivo and in vitro, as evidenced by increasing mitochondrial membrane potential, increasing ATP, decreasing reactive oxygen species production and enhancing activities of complex I and III...
April 20, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/28419719/spectroscopic-evidences-of-toxic-trans-crotonaldehyde-trapped-and-transformed-by-resveratrol-to-prevent-the-damage-of-mitochondrial-dna
#3
Yanwen Su, Lei Chen, Yanbin Su, Zhengqiang Li, Chuang Zhang, Tongxing Mu
The purpose of this study is to probe the spectroscopic evidences of toxic trans-crotonaldehyde (TCA) trapped and transformed by resveratrol (Res) to prevent the damage of mitochondrial DNA. In aldehyde dehydrogenase (ALDH) at the different pH or mitochondria, the spectroscopic characteristics of TCA trapped and transformed by Res were observed by means of both UV-vis and Raman spectra. When Res interacted with TCA, TCA peak at 316 nm immediately disappeared while Res main peak at 305 nm and shoulder peak at 320 nm were dramatically changed, Raman peaks of TCA at 1,688 cm(-1) assigned to CHO and 1,641 cm(-1) affiliated to CC were strikingly shifted, Raman peaks of Res itself were significantly displaced or disappeared, especially in mitochondria and ALDH at different pH...
April 16, 2017: IUBMB Life
https://www.readbyqxmd.com/read/28406974/resveratrol-reduces-the-apoptosis-induced-by-cigarette-smoke-extract-by-upregulating-mfn2
#4
Chao Song, Bailing Luo, Li Gong
PURPOSE: The aim of this study was to investigate the effect of resveratrol (RSV) on cigarette smoke extract (CSE)-induced cell apoptosis and mitochondrial dysfunction in vitro, as well as changes in the MFN2 expression level. METHODS: Cultured human bronchial epithelial (HBE) cells were initially treated with CSE to induce apoptosis, followed by incubation either with or without RSV. Numerous techniques were used to evaluate the outcomes of the present study, including a cell counting kit-8 assay, real-time quantitative polymerase chain reaction (real-time qPCR), western blotting, JC-1 fluorescence, Hoechst 33342 staining, Annexin V-PI flow cytometry apoptosis analyses, and siRNA technology...
2017: PloS One
https://www.readbyqxmd.com/read/28383775/polydatin-impairs-mitochondria-fitness-and-ameliorates-podocyte-injury-by-suppressing-drp1-expression
#5
Ni Zheng, Tao Liang, Xiaohui Xu, Zelin Zhao, Jiangang Liu, Zhao Song, Weikang Huo, Hongchao Xu, Qiujing Wang, Xin Li
Polydatin (PD), a resveratrol glycoside, has been shown to protect renal function in diabetic nephropathy (DN), but the underlying molecular mechanism remains unclear. This study demonstrates that PD stabilize the mitochondrial morphology and attenuate mitochondrial malfunction in both KKAy mice and in hyperglycemia (HG)-induced MPC5 cells. We use western blot analysis to demonstrate that PD reversed podocyte apoptosis induced by HG via suppressing dynamin-related protein 1 (Drp1). This effect may depend on the ability of PD to inhibit the generation of cellular reactive oxygen species (ROS)...
April 6, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28374891/short-term-hypoxia-reverses-ox-ldl-induced-cd36-and-glut4-switching-metabolic-pathways-in-h9c2-cardiomyoblast-cells
#6
Yeh-Peng Chen, Hsi-Hsien Hsu, Rathinasamy Baskaran, Su-Ying Wen, Chia-Yao Shen, Cecilia-Hsuan Day, Tsung-Jung Ho, Viswanadha Vijaya Padma, Wei-Wen Kuo, Chih-Yang Huang
High levels of circulating low-density lipoproteins (LDL, plasma proteins that carry cholesterol and triglycerides) are associated with type 2 diabetes, arteriosclerosis, obesity and hyperlipidemia. In the heart, the accumulation of oxidized low-density lipoprotein (Ox-LDL) has been proposed to play a role in the development of cardiovascular disease. We obtain cholesterol from animals and animal-derived foods such as milk, eggs and cheese. In previous studies, the ratio of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) was shown to be important for our health...
April 4, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28298149/methotrexate-induced-mitochondrial-injury-and-cytochrome-c-release-in-rat-liver-hepatocytes
#7
Abdullah Al Maruf, Peter J O'Brien, Parvaneh Naserzadeh, Rozhina Fathian, Ahmad Salimi, Jalal Pourahmad
Methotrexate (MTX) is a folic acid antagonist that is widely used to treat a variety of diseases. One of the most serious side effects of MTX therapy is hepatotoxicity. The potential molecular cytotoxic mechanisms of MTX toward isolated rat hepatocytes were investigated using Accelerated Cytotoxicity Mechanism Screening (ACMS) techniques. A concentration and time dependent increase in cytotoxicity and reactive oxygen species (ROS) formation and a decrease in mitochondrial membrane potential (MMP) were observed with MTX...
March 16, 2017: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/28286268/resveratrol-rescues-cadmium-induced-mitochondrial-injury-by-enhancing-transcriptional-regulation-of-pgc-1%C3%AE-and-sod2-via-the-sirt3-foxo3a-pathway-in-tcmk-1-cells
#8
Beibei Fu, Jiamin Zhao, Wei Peng, Haibo Wu, Yong Zhang
Resveratrol has been reported to ameliorate Cd-induced nephrotoxicity. However, the beneficial effects of resveratrol on Cd-induced nephrotoxicity and the underlying mechanisms of this protection remain unclear. Here, we showed that mouse renal tubular epithelial (TCMK-1) cells exposed to Cd experienced significantly increased mitochondrial reactive oxygen species (mROS) production, as well as decreased mitochondrial biogenesis and function. Cd exposure dramatically decreased Sirt3 protein expression and activity and promoted the acetylation of forkhead box O3 (FoxO3a)...
April 22, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28283884/resveratrol-and-brain-mitochondria-a-review
#9
REVIEW
Fernanda Rafaela Jardim, Fernando Tonon de Rossi, Marielle Xavier Nascimento, Renata Gabriele da Silva Barros, Paula Agrizzi Borges, Isabella Cristina Prescilio, Marcos Roberto de Oliveira
Resveratrol (3,4',5-trihydroxystilbene; C14H12O3) is a polyphenolic phytoalexin found in grapes, berries, peanuts, and wines. Resveratrol has been viewed as an antioxidant, anti-inflammatory, anti-apoptotic, and anticancer agent. Moreover, it has been reported that resveratrol modulates mitochondrial function, redox biology, and dynamics in both in vitro and in vivo experimental models. Resveratrol also attenuates mitochondrial impairment induced by certain stressors. Resveratrol upregulates, for example, mitochondria-located antioxidant enzymes, decreasing the production of reactive species by these organelles...
March 10, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28235489/resveratrol-stimulates-mitochondrial-fusion-by-a-mechanism-requiring-mitofusin-2
#10
Ellen L Robb, Fereshteh Moradi, Lucas A Maddalena, Andrew J F Valente, Joao Fonseca, Jeffrey A Stuart
Resveratrol (RES) is a plant-derived stilbene associated with a wide range of health benefits. Mitochondria are a key downstream target of RES, and in some cell types RES promotes mitochondrial biogenesis, altered cellular redox status, and a shift toward oxidative metabolism. Mitochondria exist as a dynamic network that continually remodels via fusion and fission processes, and the extent of fusion is related to cellular redox status and metabolism. We investigated RES's effects on mitochondrial network morphology in several cell lines using a quantitative approach to measure the extent of network fusion...
April 1, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28197625/different-effect-of-resveratrol-to-induction-of-apoptosis-depending-on-the-type-of-human-cancer-cells
#11
Michinori Takashina, Sayaka Inoue, Kei Tomihara, Kengo Tomita, Kohshi Hattori, Qing-Li Zhao, Tokiko Suzuki, Makoto Noguchi, Wakana Ohashi, Yuichi Hattori
The effect of resveratrol on various human cancer cells was investigated with special focus on apoptotic cell death, in an attempt to further characterize its mechanism of action. There were great differences in the anti-viability effect of resveratrol between different types of human cancer cells. While the inhibition of cell viability by resveratrol was marked in U937 and MOLT-4 leukemia cells, resveratrol moderately inhibited cell viability in MCF-7 breast, HepG2 liver, and A549 lung cancer cells, and the effect was slight on cell viability in Caco-2, HCT116, and SW480 colon cancer cells...
March 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28157696/resveratrol-induces-mitochondria-mediated-caspase-independent-apoptosis-in-murine-prostate-cancer-cells
#12
Sanjay Kumar, Erdal Eroglu, James A Stokes, Karyn Scissum-Gunn, Sabita N Saldanha, Udai P Singh, Upender Manne, Selvarangan Ponnazhagan, Manoj K Mishra
Found in the skins of red fruits, including grapes, resveratrol (RES) is a polyphenolic compound with cancer chemopreventive activity. Because of this activity, it has gained interest for scientific investigations. RES inhibits tumor growth and progression by targeting mitochondria-dependent or -independent pathways. However, further investigations are needed to explore the underlying mechanisms.The present study is focused on examining the role of RES-induced, mitochondria-mediated, caspase-independent apoptosis of prostate cancer cells, namely transgenic adenocarcinoma of mouse prostate (TRAMP) cells...
March 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28031523/protective-effects-of-resveratrol-against-mancozeb-induced-apoptosis-damage-in-mouse-oocytes
#13
Yu Liu, Ya-Long Wang, Shu-Wen He, Ming-Huang Chen, Zhen Zhang, Xian-Pei Fu, Bin-Bin Fu, Bao-Qiong Liao, Yan-Hong Lin, Zhong-Quan Qi, Hai-Long Wang
Mancozeb, a mixture of ethylene-bis-dithiocarbamate manganese and zinc salts, is one of the most widely used fungicides in agriculture. Mancozeb could lead to mitochondria dysfunction, cellular anti-oxidation enzymes depletion and apoptotic pathways activation. Previous studies indicated the exposure of mancozeb through mother would lead to irregular estrous cycles, decreased progesterone levels, reduced litter sizes, and more frequent delivery of dead fetuses. In this study, we investigated mancozeb inducing reproductive toxicity, especially focusing on its apoptotic effect and epigenetic modifications...
January 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/28024576/resveratrol-loaded-folic-acid-grafted-dextran-stearate-submicron-particles-exhibits-enhanced-antitumor-efficacy-in-non-small-cell-lung-cancers
#14
Qing-Sheng Zhao, Ling-Ling Hu, Zhi-Dong Wang, Zhao-Pei Li, Ai-Wen Wang, Jing Liu
In this study, we have aimed to prepare folic acid-conjugated dextran stearate (DF) polymeric micelles to target resveratrol in lung cancers. The polymeric micelle was nanosized and exhibited a controlled drug release pattern. The resveratrol (RSV)-loaded dextran stearate (RSV-DF) micelles exhibited an enhanced cellular uptake in A549 cells due to the folic acid-based receptor interactions. We have demonstrated that RSV-DF polymeric micelles retain the cytotoxic and metabolic effects of RSV on A549 cancer cells with potencies similar to that of the free compound...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28003866/sirt1-3-activation-by-resveratrol-attenuates-acute-kidney-injury-in-a-septic-rat-model
#15
Siqi Xu, Youguang Gao, Qin Zhang, Siwei Wei, Zhongqing Chen, Xingui Dai, Zhenhua Zeng, Ke-Seng Zhao
Sepsis often results in damage to multiple organ systems, possibly due to severe mitochondrial dysfunction. Two members of the sirtuin family, SIRT1 and SIRT3, have been implicated in the reversal of mitochondrial damage. The aim of this study was to determine the role of SIRT1/3 in acute kidney injury (AKI) following sepsis in a septic rat model. After drug pretreatment and cecal ligation and puncture (CLP) model reproduction in the rats, we performed survival time evaluation and kidney tissue extraction and renal tubular epithelial cell (RTEC) isolation...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27981241/high-throughput-screening-of-clinically-approved-drugs-that-prime-polyethylenimine-transfection-reveals-modulation-of-mitochondria-dysfunction-response-improves-gene-transfer-efficiencies
#16
Albert Nguyen, Jared Beyersdorf, Jean-Jack Riethoven, Angela K Pannier
Nonviral gene delivery methods are advantageous over viral vectors in terms of safety, cost, and flexibility in design and application, but suffer from lower gene transfer efficiency. In addition to modifications to nucleic acid design and nonviral carriers, new tools are sought to enhance transfection. Priming is the pharmacological modulation of transfection efficiency and transgene expression, and has demonstrated transfection increase in several compounds, for example, chloroquine and glucocorticoids. To develop a library of transfection priming compounds, a high-throughput screen was performed of the NIH Clinical Collection (NCC) to identify clinical compounds that prime polyethylenimine (PEI) transfection...
June 2016: Bioengineering & Translational Medicine
https://www.readbyqxmd.com/read/27958670/resveratrol-attenuates-mitochondrial-dysfunction-in-the-liver-of-intrauterine-growth-retarded-suckling-piglets-by-improving-mitochondrial-biogenesis-and-redox-status
#17
Hao Zhang, Yue Li, Weipeng Su, Zhixiong Ying, Le Zhou, Lili Zhang, Tian Wang
SCOPE: Emerging evidence has identified mitochondrial biogenesis and oxidative phosphorylation as potential targets for the prevention and treatment of metabolic syndrome. This study investigated the effect of resveratrol (RSV) on hepatic mitochondrial function in intrauterine growth-retarded (IUGR) suckling piglets. METHODS AND RESULTS: Seven normal birth weight (NBW) and fourteen IUGR neonatal male piglets were selected. Piglets were fed control diets supplemented with 0 (NBW-CON), 0 (IUGR-CON), and 1...
December 13, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27938439/the-antileishmanial-activity-of-xanthohumol-is-mediated-by-mitochondrial-inhibition
#18
Lianet Monzote, Alexandra Lackova, Katrin Staniek, Silvia Steinbauer, Gerald Pichler, Walter Jäger, Lars Gille
Xanthohumol (Xan) is a natural constituent of human nutrition. Little is known about its actions on leishmanial parasites and their mitochondria as putative target. Therefore, we determined the antileishmanial activity of Xan and resveratrol (Res, as alternative compound with antileishmanial activity) with respect to mitochondria in Leishmania amazonensis promastigotes/amastigotes (LaP/LaA) in comparison with their activity in peritoneal macrophages from mouse (PMM) and macrophage cell line J774A.1 (J774). Mechanistic studies were conducted in Leishmania tarentolae promastigotes (LtP) and mitochondrial fractions isolated from LtP...
December 12, 2016: Parasitology
https://www.readbyqxmd.com/read/27931585/resveratrol-ameliorated-vascular-calcification-by-regulating-sirt-1-and-nrf2
#19
P Zhang, Y Li, Y Du, G Li, L Wang, F Zhou
Pathologic vascular calcification is a significant reason for mortality and morbidity in patients who suffer from end-stage renal disease (ESRD). Resveratrol, a scavenger for many free radicals, is a crucial compound for biomedicine. However, the role and mechanism of resveratrol in vascular calcification is still unknown. In this study, to mimic vascular calcification in ESRD, we used β-glyceophosphate to stimulate the rat vascular smooth muscle cells (RASMCs). We investigate the therapeutic role of resveratrol pretreatment in vascular calcification...
December 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27611176/autophagy-and-mitochondrial-dysfunction-in-adjuvant-arthritis-rats-treatment-with-resveratrol
#20
Junqiang Zhang, Xianbin Song, Wei Cao, Jinseng Lu, Xiaoqing Wang, Gaoyuan Wang, Zhicheng Wang, Xiaoyu Chen
Resveratrol is a polyphenol derivatives which exhibits a pro-apoptotic effect in a variety of human cancers by triggering mitochondria apoptosis pathway and autophagy. However, there are scarcely reports on its apoptosis-promoting effect in abnormal proliferation fibroblast-like synoviocytes (FLSs). In this study, we investigated the underlying mechanism and apoptosis-inducing effects of resveratrol on the abnormal proliferation of FLSs in adjuvant-arthritis (AA) rats. Since using resveratrol for 12 days resulted in a significant decreasing the swelling degree of the paw, reducing malondialdehyde (MDA) content and enhancing superoxide dismutase (SOD) activity, antioxidant capacity, glutathione peroxidase and glutathione reductase ratio in AA rats...
September 9, 2016: Scientific Reports
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