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Resveratrol AND Mitochondria

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https://www.readbyqxmd.com/read/28197625/different-effect-of-resveratrol-to-induction-of-apoptosis-depending-on-the-type-of-human-cancer-cells
#1
Michinori Takashina, Sayaka Inoue, Kei Tomihara, Kengo Tomita, Kohshi Hattori, Qing-Li Zhao, Tokiko Suzuki, Makoto Noguchi, Wakana Ohashi, Yuichi Hattori
The effect of resveratrol on various human cancer cells was investigated with special focus on apoptotic cell death, in an attempt to further characterize its mechanism of action. There were great differences in the anti-viability effect of resveratrol between different types of human cancer cells. While the inhibition of cell viability by resveratrol was marked in U937 and MOLT-4 leukemia cells, resveratrol moderately inhibited cell viability in MCF-7 breast, HepG2 liver, and A549 lung cancer cells, and the effect was slight on cell viability in Caco-2, HCT116, and SW480 colon cancer cells...
March 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28157696/resveratrol-induces-mitochondria-mediated-caspase-independent-apoptosis-in-murine-prostate-cancer-cells
#2
Sanjay Kumar, Erdal Eroglu, James A Stokes, Karyn Scissum-Gunn, Sabita N Saldanha, Udai P Singh, Upender Manne, Selvarangan Ponnazhagan, Manoj K Mishra
Found in the skins of red fruits, including grapes, resveratrol (RES) is a polyphenolic compound with cancer chemopreventive activity. Because of this activity, it has gained interest for scientific investigations. RES inhibits tumor growth and progression by targeting mitochondria-dependent or -independent pathways. However, further investigations are needed to explore the underlying mechanisms.The present study is focused on examining the role of RES-induced, mitochondria-mediated, caspase-independent apoptosis of prostate cancer cells, namely transgenic adenocarcinoma of mouse prostate (TRAMP) cells...
February 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28031523/protective-effects-of-resveratrol-against-mancozeb-induced-apoptosis-damage-in-mouse-oocytes
#3
Yu Liu, Ya-Long Wang, Shu-Wen He, Ming-Huang Chen, Zhen Zhang, Xian-Pei Fu, Bin-Bin Fu, Bao-Qiong Liao, Yan-Hong Lin, Zhong-Quan Qi, Hai-Long Wang
Mancozeb, a mixture of ethylene-bis-dithiocarbamate manganese and zinc salts, is one of the most widely used fungicides in agriculture. Mancozeb could lead to mitochondria dysfunction, cellular anti-oxidation enzymes depletion and apoptotic pathways activation. Previous studies indicated the exposure of mancozeb through mother would lead to irregular estrous cycles, decreased progesterone levels, reduced litter sizes, and more frequent delivery of dead fetuses. In this study, we investigated mancozeb inducing reproductive toxicity, especially focusing on its apoptotic effect and epigenetic modifications...
January 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/28024576/resveratrol-loaded-folic-acid-grafted-dextran-stearate-submicron-particles-exhibits-enhanced-antitumor-efficacy-in-non-small-cell-lung-cancers
#4
Qing-Sheng Zhao, Ling-Ling Hu, Zhi-Dong Wang, Zhao-Pei Li, Ai-Wen Wang, Jing Liu
In this study, we have aimed to prepare folic acid-conjugated dextran stearate (DF) polymeric micelles to target resveratrol in lung cancers. The polymeric micelle was nanosized and exhibited a controlled drug release pattern. The resveratrol (RSV)-loaded dextran stearate (RSV-DF) micelles exhibited an enhanced cellular uptake in A549 cells due to the folic acid-based receptor interactions. We have demonstrated that RSV-DF polymeric micelles retain the cytotoxic and metabolic effects of RSV on A549 cancer cells with potencies similar to that of the free compound...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28003866/sirt1-3-activation-by-resveratrol-attenuates-acute-kidney-injury-in-a-septic-rat-model
#5
Siqi Xu, Youguang Gao, Qin Zhang, Siwei Wei, Zhongqing Chen, Xingui Dai, Zhenhua Zeng, Ke-Seng Zhao
Sepsis often results in damage to multiple organ systems, possibly due to severe mitochondrial dysfunction. Two members of the sirtuin family, SIRT1 and SIRT3, have been implicated in the reversal of mitochondrial damage. The aim of this study was to determine the role of SIRT1/3 in acute kidney injury (AKI) following sepsis in a septic rat model. After drug pretreatment and cecal ligation and puncture (CLP) model reproduction in the rats, we performed survival time evaluation and kidney tissue extraction and renal tubular epithelial cell (RTEC) isolation...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27981241/high-throughput-screening-of-clinically-approved-drugs-that-prime-polyethylenimine-transfection-reveals-modulation-of-mitochondria-dysfunction-response-improves-gene-transfer-efficiencies
#6
Albert Nguyen, Jared Beyersdorf, Jean-Jack Riethoven, Angela K Pannier
Nonviral gene delivery methods are advantageous over viral vectors in terms of safety, cost, and flexibility in design and application, but suffer from lower gene transfer efficiency. In addition to modifications to nucleic acid design and nonviral carriers, new tools are sought to enhance transfection. Priming is the pharmacological modulation of transfection efficiency and transgene expression, and has demonstrated transfection increase in several compounds, for example, chloroquine and glucocorticoids. To develop a library of transfection priming compounds, a high-throughput screen was performed of the NIH Clinical Collection (NCC) to identify clinical compounds that prime polyethylenimine (PEI) transfection...
June 2016: Bioeng Transl Med
https://www.readbyqxmd.com/read/27958670/resveratrol-attenuates-mitochondrial-dysfunction-in-the-liver-of-intrauterine-growth-retarded-suckling-piglets-by-improving-mitochondrial-biogenesis-and-redox-status
#7
Hao Zhang, Yue Li, Weipeng Su, Zhixiong Ying, Le Zhou, Lili Zhang, Tian Wang
SCOPE: Emerging evidence has identified mitochondrial biogenesis and oxidative phosphorylation as potential targets for the prevention and treatment of metabolic syndrome. This study investigated the effect of resveratrol (RSV) on hepatic mitochondrial function in intrauterine growth-retarded (IUGR) suckling piglets. METHODS AND RESULTS: Seven normal birth weight (NBW) and fourteen IUGR neonatal male piglets were selected. Piglets were fed control diets supplemented with 0 (NBW-CON), 0 (IUGR-CON), and 1...
December 13, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27938439/the-antileishmanial-activity-of-xanthohumol-is-mediated-by-mitochondrial-inhibition
#8
Lianet Monzote, Alexandra Lackova, Katrin Staniek, Silvia Steinbauer, Gerald Pichler, Walter Jäger, Lars Gille
Xanthohumol (Xan) is a natural constituent of human nutrition. Little is known about its actions on leishmanial parasites and their mitochondria as putative target. Therefore, we determined the antileishmanial activity of Xan and resveratrol (Res, as alternative compound with antileishmanial activity) with respect to mitochondria in Leishmania amazonensis promastigotes/amastigotes (LaP/LaA) in comparison with their activity in peritoneal macrophages from mouse (PMM) and macrophage cell line J774A.1 (J774). Mechanistic studies were conducted in Leishmania tarentolae promastigotes (LtP) and mitochondrial fractions isolated from LtP...
December 12, 2016: Parasitology
https://www.readbyqxmd.com/read/27931585/resveratrol-ameliorated-vascular-calcification-by-regulating-sirt-1-and-nrf2
#9
P Zhang, Y Li, Y Du, G Li, L Wang, F Zhou
Pathologic vascular calcification is a significant reason for mortality and morbidity in patients who suffer from end-stage renal disease (ESRD). Resveratrol, a scavenger for many free radicals, is a crucial compound for biomedicine. However, the role and mechanism of resveratrol in vascular calcification is still unknown. In this study, to mimic vascular calcification in ESRD, we used β-glyceophosphate to stimulate the rat vascular smooth muscle cells (RASMCs). We investigate the therapeutic role of resveratrol pretreatment in vascular calcification...
December 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27611176/autophagy-and-mitochondrial-dysfunction-in-adjuvant-arthritis-rats-treatment-with-resveratrol
#10
Junqiang Zhang, Xianbin Song, Wei Cao, Jinseng Lu, Xiaoqing Wang, Gaoyuan Wang, Zhicheng Wang, Xiaoyu Chen
Resveratrol is a polyphenol derivatives which exhibits a pro-apoptotic effect in a variety of human cancers by triggering mitochondria apoptosis pathway and autophagy. However, there are scarcely reports on its apoptosis-promoting effect in abnormal proliferation fibroblast-like synoviocytes (FLSs). In this study, we investigated the underlying mechanism and apoptosis-inducing effects of resveratrol on the abnormal proliferation of FLSs in adjuvant-arthritis (AA) rats. Since using resveratrol for 12 days resulted in a significant decreasing the swelling degree of the paw, reducing malondialdehyde (MDA) content and enhancing superoxide dismutase (SOD) activity, antioxidant capacity, glutathione peroxidase and glutathione reductase ratio in AA rats...
September 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27606689/resveratrol-specifically-kills-cancer-cells-by-a-devastating-increase-in-the-ca2-coupling-between-the-greatly-tethered-endoplasmic-reticulum-and-mitochondria
#11
Corina T Madreiter-Sokolowski, Benjamin Gottschalk, Warisara Parichatikanond, Emrah Eroglu, Christiane Klec, Markus Waldeck-Weiermair, Roland Malli, Wolfgang F Graier
BACKGROUND/AIMS: Resveratrol and its derivate piceatannol are known to induce cancer cell-specific cell death. While multiple mechanisms of actions have been described including the inhibition of ATP synthase, changes in mitochondrial membrane potential and ROS levels, the exact mechanisms of cancer specificity of these polyphenols remain unclear. This paper is designed to reveal the molecular basis of the cancer-specific initiation of cell death by resveratrol and piceatannol. METHODS: The two cancer cell lines EA...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27551266/benzo-a-pyrene-induced-p53-mediated-male-germ-cell-apoptosis-synergistic-protective-effects-of-curcumin-and-resveratrol
#12
Bhaswati Banerjee, Supriya Chakraborty, Debidas Ghosh, Sanghamitra Raha, Parimal C Sen, Kuladip Jana
Benzo(a)pyrene (B(a)P) is an environmental toxicant that induces male germ cell apoptosis. Curcumin and resveratrol are phytochemicals with cytoprotective and anti-oxidative properties. At the same time resveratrol is also a natural Aryl hydrocarbon Receptor (AhR) antagonist. Our present study in isolated testicular germ cell population from adult male Wistar rats, highlighted the synergistic protective effect of curcumin and resveratrol against B(a)P induced p53 mediated germ cell apoptosis. Curcumin-resveratrol significantly prevented B(a)P induced decrease in sperm cell count and motility, as well as increased serum testosterone level...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27519633/low-oxygen-level-increases-proliferation-and-metabolic-changes-in-bovine-granulosa-cells
#13
Shogo Shiratsuki, Tomotaka Hara, Yasuhisa Munakata, Koumei Shirasuna, Takehito Kuwayama, Hisataka Iwata
The present study addresses molecular backgrounds underlying low oxygen induced metabolic changes and 1.2-fold change in bovine granulosa cell (GCs) proliferation. RNA-seq revealed that low oxygen (5%) upregulated genes associated with HIF-1 and glycolysis and downregulated genes associated with mitochondrial respiration than that in high oxygen level (21%). Low oxygen level induced high glycolytic activity and low mitochondrial function and biogenesis. Low oxygen level enhanced GC proliferation with high expression levels of HIF-1, VEGF, AKT, mTOR, and S6RP, whereas addition of anti-VEGF antibody decreased cellular proliferation with low phosphorylated AKT and mTOR expression levels...
December 5, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27490778/cstmp-induces-apoptosis-and-mitochondrial-dysfunction-in-human-myeloma-rpmi8226-cells-via-chop-dependent-endoplasmic-reticulum-stress
#14
Xing Sun, Wang Liao, Jialing Wang, Ping Wang, Hongxiu Gao, Meng Wang, Chunling Xu, Yaping Zhong, Yan Ding
BACKGROUND: The natural product tetramethylpyrazine (TMP) and resveratrol have a variety of biologic activities, including anti-cancer effects. However the pharmacological function of CSTMP (a newly designed and synthesized TMP and resveratrol derivative) in cancer have not been elucidated. METHODS: In RPMI8226 cells, the cytotoxic effects and apoptosis were detected by MTT and Double staining for Annexin V-FITC and propidium iodide (PI). The protein and mRNA expression levels were detected by Real Time PCR and Western blot, respectively...
October 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27489133/the-protective-effect-of-resveratrol-against-cytotoxicity-induced-by-mycotoxin-zearalenone
#15
Yaqiu Sang, Wenzhu Li, Genyi Zhang
Zearalenone (ZEA), a non-steroidal estrogenic mycotoxin, is widely present in cereals and agricultural products. The literature reports suggest that oxidative damage seems to be a key determinant of ZEA-induced toxicity, and the protective effect of resveratrol (RSV), an antioxidant phenolic compound, on ZEA-induced cytotoxicity to HEK293 cells was investigated. The experimental results showed that ZEA decreased cell viability in a dose dependent manner with an IC50 value of 80 μM, and induced an increase in intracellular reactive oxygen species (ROS) in HEK293 cells...
September 14, 2016: Food & Function
https://www.readbyqxmd.com/read/27470364/ire1%C3%AE-traf2-ask1-pathway-is-involved-in-cstmp-induced-apoptosis-and-er-stress-in-human-non-small-cell-lung-cancer-a549-cells
#16
Jiexia Zhang, Ying Liang, Yongbin Lin, Yuanbin Liu, YouYou, Weiqiang Yin
BACKGROUND: CSTMP, a Tetramethylpyrazine (TMP) analogue, is designed and synthesized based on the pharmacophores of TMP and resveratrol. Recent studies showed that CSTMP had strong protective effects in endothelial cells apoptosis by its anti-oxidant activity. However, the pharmacological function of CSTMP in cancer have not been elucidated to date. The objective of this study was to investigate the anti-cancer effect of CSTMP against human non-small cell lung cancer (NSCLC) A549 cells and the underlying mechanisms...
August 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27400479/use-of-microbial-fuel-cells-to-monitor-current-production-in-qi-deficient-liver-cells
#17
Karen Poon, Lexin Liang, Chang Xu
OBJECTIVE: To monitor current production in Qi-deficient liver cells, and to study how cellular proton leakage might affect electric current production. METHODS: Cells were placed in an microbial fuel cells (MFC) anode and the electric current was measured. Mitochondrial-affecting chemicals, 2,4-dinitrophenol (DNP) and resveratrol (RVT), were used to induce proton leakage in cells and their effect on current production observed. MCF-7 breast cancer cells exhibited higher proton leakage relative to normal liver cells...
April 2016: Journal of Traditional Chinese Medicine, Chung i Tsa Chih Ying Wen Pan
https://www.readbyqxmd.com/read/27373419/signaling-mechanisms-underlying-the-glioprotective-effects-of-resveratrol-against-mitochondrial-dysfunction
#18
Bruna Bellaver, Larissa Daniele Bobermin, Débora Guerini Souza, Marília Danielly Nunes Rodrigues, Adriano Martimbianco de Assis, Moacir Wajner, Carlos-Alberto Gonçalves, Diogo Onofre Souza, André Quincozes-Santos
Resveratrol, a polyphenol found in grapes and red wine, exhibits antioxidant, anti-inflammatory, anti-aging and, neuroprotective effects. Resveratrol also plays a significant role modulating glial functionality, protecting the health of neuroglial cells against several neuropsychiatric in vivo and in vitro experimental models. Mitochondrial impairment strongly affected astrocyte functions and consequently brain homeostasis. Molecules that promote astrocyte mitochondrial protection are fundamental to maintain brain energy balance and cellular redox state, contributing to brain healthy...
September 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27344270/bedaquiline-an-fda-approved-antibiotic-inhibits-mitochondrial-function-and-potently-blocks-the-proliferative-expansion-of-stem-like-cancer-cells-cscs
#19
Marco Fiorillo, Rebecca Lamb, Herbert B Tanowitz, Anna Rita Cappello, Ubaldo E Martinez-Outschoorn, Federica Sotgia, Michael P Lisanti
Bedaquiline (a.k.a., Sirturo) is an anti-microbial agent, which is approved by the FDA for the treatment of multi-drug resistant pulmonary tuberculosis (TB). Bedaquiline is a first-in-class diaryl-quinoline compound, that mechanistically inhibits the bacterial ATP-synthase, and shows potent activity against both drug-sensitive and drug-resistant TB. Interestingly, eukaryotic mitochondria originally evolved from engulfed aerobic bacteria. Thus, we hypothesized that, in mammalian cells, bedaquiline might also target the mitochondrial ATP-synthase, leading to mitochondrial dysfunction and ATP depletion...
August 2016: Aging
https://www.readbyqxmd.com/read/27340138/polydatin-post-treatment-alleviates-myocardial-ischaemia-reperfusion-injury-by-promoting-autophagic-flux
#20
Yuanna Ling, Guiming Chen, Yi Deng, Huixiong Tang, Long Ling, Xiaoming Zhou, Xudong Song, Pingzhen Yang, Yingfeng Liu, Zhiliang Li, Cong Zhao, Yufei Yang, Xianbao Wang, Masafumi Kitakaze, Yulin Liao, Aihua Chen
Polydatin (PD), a resveratrol (RES) glycoside, has a stronger antioxidative effect than RES. It is known that RES is an autophagic enhancer and exerts a cardioprotective effect against ischaemia/reperfusion (I/R) injury. However, the effect of PD post-treatment on myocardial I/R injury remains unclear. In the present study, we investigated the influences of PD post-treatment on myocardial I/R injury and autophagy. C57BL/6 mice underwent left coronary artery (LCA) occlusion and cultured neonatal rat cardiomyocytes (NRCs) subjected to hypoxia were treated with vehicle or PD during reperfusion or re-oxygenation...
September 1, 2016: Clinical Science (1979-)
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