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toxic shock streptococcal syndrome

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https://www.readbyqxmd.com/read/29868022/the-surface-exposed-protein-snta-contributes-to-complement-evasion-in-zoonotic-streptococcus-suis
#1
Simin Deng, Tong Xu, Qiong Fang, Lei Yu, Jiaqi Zhu, Long Chen, Jiahui Liu, Rui Zhou
Streptococcus suis is an emerging zoonotic pathogen causing streptococcal toxic shock like syndrome (STSLS), meningitis, septicemia, and even sudden death in human and pigs. Serious septicemia indicates this bacterium can evade the host complement surveillance. In our previous study, a functionally unknown protein SntA of S. suis has been identified as a heme-binding protein, and contributes to virulence in pigs. SntA can interact with the host antioxidant protein AOP2 and consequently inhibit its antioxidant activity...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29788397/polyspecific-intravenous-immunoglobulin-in-clindamycin-treated-patients-with-streptococcal-toxic-shock-syndrome-a-systematic-review-and-meta-analysis
#2
Tom Parks, Clare Wilson, Nigel Curtis, Anna Norrby-Teglund, Shiranee Sriskandan
We evaluated the effect of adjunctive intravenous immunoglobulin (IVIG) on mortality in clindamycin-treated streptococcal toxic shock syndrome patients using a meta-analysis. In association with IVIG, mortality fell from 33.7% to 15.7% (risk ratio 0.46, 95% confidence intervals 0.26-0.83, p=0.010) with remarkable consistency across the single randomised and four non-randomised studies.
May 17, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29741523/fulminant-streptococcal-toxic-shock-syndrome
#3
S Zavala, M Arias, P Legua
We present a case of a previously healthy 37-year-old male who developed fever, nausea, vomiting, diarrhoea, and hypovolaemia. Within 5.5 h he presented with tachycardia, tachypnoea, became hypotensive and displayed a diffuse erythematous rash. In the following hours he developed persistent hypotension, acute respiratory distress syndrome, liver failure, kidney failure and disseminated intravascular coagulation. A diagnosis of toxic shock syndrome was made, but despite antibiotic therapy, immunoglobulin administration, and supportive measures, the patient died 50 h after presentation...
March 2018: Journal of the Royal College of Physicians of Edinburgh
https://www.readbyqxmd.com/read/29722472/fulminant-group-a-streptococcal-infection-without-gangrene-in-the-extremities-analysis-of-five-autopsy-cases
#4
Shu Kato, Motoi Yanazaki, Kino Hayashi, Fumiko Satoh, Ichiro Isobe, Yutaka Tsutsumi
Five autopsy cases of fulminant group A streptococcal infection without gangrene in the extremities are presented. Clinical course of the fulminant illness was short (2-4 days). One pathological autopsy case was aged (86-years-old), and hemorrhagic cystitis was observed. The other four forensic autopsy cases were young (24-38 years-old) with the mean age of 32, and the primary infective lesions were located in the postpartum endometrium, tonsil and bronchus (2 cases). Systemic coccal dissemination with poor neutrophilic reaction was seen in two of five cases...
May 3, 2018: Pathology International
https://www.readbyqxmd.com/read/29619033/triggering-receptor-expressed-on-myeloid-cells-1-signaling-protective-and-pathogenic-roles-on-streptococcal-toxic-shock-like-syndrome-caused-by-streptococcus-suis
#5
REVIEW
Li Han, Lei Fu, Yongbo Peng, Anding Zhang
Streptococcus suis infections can cause septic shock, which is referred to as streptococcal toxic-shock-like syndrome (STSLS). The disease is characterized by a severe inflammatory response, multiple organ failure, and high mortality. However, no superantigen that is responsible for toxic shock syndrome was detected in S. suis , indicating that the mechanism underlying STSLS is different and remains to be elucidated. Triggering receptor expressed on myeloid cells-1 (TREM-1), belonging to the Ig superfamily, is an activating receptor expressed on myeloid cells, and has been recognized as a critical immunomodulator in several inflammatory diseases of both infectious and non-infectious etiologies...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29601458/epidemiology-and-clinical-relevance-of-toxic-shock-syndrome-in-us-children
#6
James T Gaensbauer, Meghan Birkholz, Michael A Smit, Roger Garcia, James K Todd
INTRODUCTION: It is important for clinicians to recognize the contribution of toxic shock syndrome (TSS) to the overall burden of pediatric septic shock because the clinical features, optimal therapy and prognosis differ from non-TSS septic shock. METHODS: We analyzed cases of pediatric septic shock reported to the Pediatric Health Information Systems (PHIS) database between 2009 and 2013 to define the clinical and demographic characteristics of pediatric TSS in the US...
March 27, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29581121/dextromethorphan-attenuates-nadph-oxidase-regulated-glycogen-synthase-kinase-3%C3%AE-and-nf-%C3%AE%C2%BAb-activation-and-reduces-nitric-oxide-production-in-group-a-streptococcal-infection
#7
Chia-Ling Chen, Miao-Huei Cheng, Chih-Feng Kuo, Yi-Lin Cheng, Ming-Han Li, Chih-Peng Chang, Jiunn-Jong Wu, Robert Anderson, Shuying Wang, Pei-Jane Tsai, Ching-Chuan Liu, Yee-Shin Lin
Group A Streptococcus (GAS) is an important human pathogen that causes a wide spectrum of diseases, including necrotizing fasciitis and streptococcal toxic shock syndrome. Dextromethorphan (DM), an antitussive drug, has been demonstrated to efficiently reduce inflammatory responses, thereby contributing to an increased survival rate of GAS-infected mice. However, the anti-inflammatory mechanisms underlying DM treatment in GAS infection remain unclear. DM is known to exert neuroprotective effects through an NADPH oxidase-dependent regulated process...
June 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29457020/infective-endocarditis-associated-with-streptococcal-toxic-shock-syndrome-due-to-streptococcus-dysgalactiae-subsp-equisimilis-infection-in-a-hemodialysis-patient
#8
Momoko Kan, Yasukiyo Mori, Nao Kishimoto, Hiroki Shibutani, Yuno Tomita, Tomoko Hagino, Eiko Ohira, Masahiro Karakawa
The risk of infective endocarditis in chronic hemodialysis patients is markedly higher than that in the general population. We report the first case of a hemodialysis patient with infective endocarditis caused by Streptococcus dysgalactiae subsp. equisimilis (SDSE) who presented with streptococcal toxic shock syndrome. In the last decade, there has been an increase in the incidence of SDSE infections. Therefore, it is important to recognize SDSE as a possible causative agent of infective endocarditis in an immunocompromised population, such as hemodialysis patients...
September 2017: Case Reports in Nephrology and Dialysis
https://www.readbyqxmd.com/read/29384948/treatment-with-antibodies-against-primary-group-a-streptococcal-peritonitis-a-case-report-and-a-review-of-the-literature
#9
Daisuke Iitaka, Fumiaki Ochi, Susumu Nakashima, Jyunshin Fujiyama, Mamoru Masuyama
RATIONALE: Several reports describe severe group A streptococcal (GAS) infections causing septic shock, soft-tissue necrosis, and multiple organ failure known as streptococcal toxic shock syndrome (STSS). However, primary peritonitis with GAS is rare and most of them were undertaken surgical procedure. PATIENT CONCERNS: We herein reported the case of 26-year-old healthy woman with sudden severe abdominal pain and hypotension. Computed tomography (CT) showed that large amount of free fluid in the peritoneal cavity consist with peritonitis, and no free air...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29359701/deletion-of-from-streptococcus-pyogenes-results-in-hypervirulence-in-a-mouse-model-of-sepsis-and-is-luxs-independent
#10
Izabela Sitkiewicz, James M Musser
Group A Streptococcus (GAS) is a Gram-positive human pathogen that causes a variety of diseases ranging from pharyngitis to life-threatening streptococcal toxic shock syndrome. Recently, several global gene expression analyses have yielded extensive new information regarding the regulation of genes encoding known and putative virulence factors in GAS. A microarray analysis found that transcription of the GAS gene M5005_Spy_1343 was significantly increased in response to interaction with human polymorphonuclear leukocytes...
March 30, 2017: Polish Journal of Microbiology
https://www.readbyqxmd.com/read/29284248/streptococcus-suis-a-re-emerging-pathogen-associated-with-occupational-exposure-to-pigs-or-pork-products-part-i-epidemiology
#11
Jacek Dutkiewicz, Jacek Sroka, Violetta Zając, Bernard Wasiński, Ewa Cisak, Anna Sawczyn, Anna Kloc, Angelina Wójcik-Fatla
<i>Streptococcus suis</i> (ex Elliot 1966, Kilpper-Bälz & Schleifer 1987) is a facultatively anaerobic Gram-positive ovoid or coccal bacterium surrounded by a polysaccharide capsule. Based on the antigenic diversity of the capsule, <i>S. suis</i> strains are classified serologically into 35 serotypes. <i>Streptococcus suis</i> is a commensal of pigs, commonly colonizing their tonsils and nasal cavities, mostly in weaning piglets between 4-10 weeks of age. This species occurs also in cattle and other mammals, in birds and in humans...
December 23, 2017: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/29109702/genomic-comparison-among-lethal-invasive-strains-of-streptococcus-pyogenes-serotype-m1
#12
Gabriel R Fernandes, Aulus E A D Barbosa, Renan N Almeida, Fabíola F Dos S Castro, Marina de C P da Ponte, Celio Faria-Junior, Fernanda M P Müller, Antônio A B Viana, Dario Grattapaglia, Octavio L Franco, Sérgio A Alencar, Simoni C Dias
Streptococcus pyogenes , also known as group A Streptococcus (GAS), is a human pathogen that causes diverse human diseases including streptococcal toxic shock syndrome (STSS). A GAS outbreak occurred in Brasilia, Brazil, during the second half of the year 2011, causing 26 deaths. Whole genome sequencing was performed using Illumina platform. The sequences were assembled and genes were predicted for comparative analysis with emm type 1 strains: MGAS5005 and M1 GAS. Genomics comparison revealed one of the invasive strains that differ from others isolates and from emm 1 reference genomes...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29107650/molecular-characterization-and-antibiotic-resistance-of-streptococcus-dysgalactiae-subspecies-equisimilis-isolated-from-patients-with-streptococcal-toxic-shock-syndrome
#13
T Ikebe, R Okuno, M Sasaki, Y Kanda, H Otsuka, R Kawahara, H Ohya, M Suzuki, K Uchida, H Nihonmatsu, M Ohnishi
Streptococcal toxic shock syndrome (STSS) is a severe invasive infection characterized by the sudden onset of shock, multiorgan failure, and high mortality. Although STSS is mainly caused by Streptococcus pyogenes, group G streptococcus identified as S. dysgalactiae subsp. equisimilis (SDSE) causing STSS has also been reported; however, no study has analyzed >100 isolates of SDSE causing STSS. Therefore, we characterized the emm genotype of 173 SDSE isolates obtained from STSS patients in Japan during 2014-2016 and performed antimicrobial susceptibility testing using the broth microdilution method and emm gene typing...
February 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29097247/emerging-group-c-and-group-g-streptococcal-endocarditis-a-canadian-perspective
#14
Sylvain A Lother, Davinder S Jassal, Philippe Lagacé-Wiens, Yoav Keynan
OBJECTIVES: The aim of this study was to determine the incidence of infective endocarditis (IE) in patients with bacteremia caused by group C and group G streptococci (GCGS) and to characterize the burden of disease, clinical characteristics, and outcomes through a case series of patients with GCGS IE. METHODS: Individuals with blood cultures growing GCGS in Manitoba, Canada, between January 2012 and December 2015 were included. Clinical and echocardiographic parameters were collected retrospectively...
December 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28973822/leucocyte-recruitment-and-molecular-fortification-of-keratinocytes-triggered-by-streptococcal-m1-protein
#15
Sandra T Persson, Simon Hauri, Johan Malmström, Heiko Herwald
Streptococcus pyogenes of the M1 serotype is commonly associated with invasive streptococcal infections and development of streptococcal toxic shock syndrome. The M1 protein is a powerful inducer of inflammatory responses for several human cell types, but the reason why M1 protein-related strains is over-represented in invasive streptococcal diseases is still not understood. This study was undertaken to investigate if soluble M1 protein can aggravate the severity of streptococcal skin infections in respect to inflammation, leucocyte recruitment, and tissue remodelling as seen in patients with cellulitis and necrotizing fasciitis...
January 2018: Cellular Microbiology
https://www.readbyqxmd.com/read/28954758/rare-presentation-of-necrotising-fasciitis-and-streptococcal-toxic-shock-syndrome-by-group-a-streptococcus
#16
Saqib Saeed, Sara Alothman, Leaque Ahmed, Brian Donaldson
No abstract text is available yet for this article.
September 27, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28951316/streptococcus-pyogenes-camp-factor-promotes-bacterial-adhesion-and-invasion-in-pharyngeal-epithelial-cells-without-serum-via-pi3k-akt-signaling-pathway
#17
Mie Kurosawa, Masataka Oda, Hisanori Domon, Toshihito Isono, Yuki Nakamura, Issei Saitoh, Haruaki Hayasaki, Masaya Yamaguchi, Shigetada Kawabata, Yutaka Terao
Streptococcus pyogenes is a bacterium that causes systemic diseases, such as pharyngitis and toxic shock syndrome, via oral- or nasal-cavity infection. S. pyogenes produces various molecules known to function with serum components that lead to bacterial adhesion and invasion in human tissues. In this study, we identified a novel S. pyogenes adhesin/invasin. Our results revealed that CAMP factor promoted streptococcal adhesion and invasion in pharyngeal epithelial Detroit562 cells without serum. Recombinant CAMP factor initially localized on the membranes of cells and then became internalized in the cytosol following S...
January 2018: Microbes and Infection
https://www.readbyqxmd.com/read/28803736/an-aggressive-and-fatal-craniofacial-group-a-streptococcus-infection-resulting-from-a-minimally-displaced-orbital-floor-fracture
#18
R M Uhrich, M Sherban, C Valdez
While sharp, penetrating trauma is often associated with group A Streptococcus (GAS) infections and subsequent necrotizing fasciitis (NF) and streptococcal toxic shock syndrome (STSS), there are scant reports in the oral and maxillofacial surgery literature regarding blunt, non-penetrating trauma in association with these conditions. With a clinical course that initially appears relatively benign following blunt trauma, NF can progress swiftly through the fascial planes and may quickly become life-threatening if the oral and maxillofacial surgeon fails to recognize some of the critical pathognomonic signs...
January 2018: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28794279/nasopharyngeal-infection-by-streptococcus-pyogenes-requires-superantigen-responsive-v%C3%AE-specific-t-cells
#19
Joseph J Zeppa, Katherine J Kasper, Ivor Mohorovic, Delfina M Mazzuca, S M Mansour Haeryfar, John K McCormick
The globally prominent pathogen Streptococcus pyogenes secretes potent immunomodulatory proteins known as superantigens (SAgs), which engage lateral surfaces of major histocompatibility class II molecules and T-cell receptor (TCR) β-chain variable domains (Vβs). These interactions result in the activation of numerous Vβ-specific T cells, which is the defining activity of a SAg. Although streptococcal SAgs are known virulence factors in scarlet fever and toxic shock syndrome, mechanisms by how SAgs contribute to the life cycle of S...
August 9, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28790435/emergence-of-a-streptococcus-dysgalactiae-subspecies-equisimilis-stg62647-lineage-associated-with-severe-clinical-manifestations
#20
Oddvar Oppegaard, Haima Mylvaganam, Steinar Skrede, Paul Christoffer Lindemann, Bård Reiakvam Kittang
Increasing incidence rates of invasive Streptococcus dysgalactiae subspecies equisimilis (SDSE) infections have been reported worldwide, but the evolutionary mechanisms underlying this development remain elusive. Through prospective surveillance of invasive SDSE infections in western Norway, we observed the emergence of a novel and virulent SDSE genotype, stG62647. This emm-type, rarely encountered as a cause of invasive disease during 1999-2012, emerged in 2013 as the predominant SDSE-genotype. The stG62647-infections were associated with an aggressive clinical course, including the occurrence of streptococcal toxic shock syndrome, necrotizing soft-tissue infections and endocarditis...
August 8, 2017: Scientific Reports
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