keyword
MENU ▼
Read by QxMD icon Read
search

Toxic shock

keyword
https://www.readbyqxmd.com/read/29142545/rapid-screening-of-pyogenic-staphylococcus-aureus-for-confirmation-of-genus-and-species-methicillin-resistance-and-virulence-factors-by-using-two-novel-multiplex-pcr
#1
Abdul Haque, Asma Haque, Muhammad Saeed, Aysha Azhar, Samreen Rasool, Sidra Shan, Beenish Ehsan, Zohaib Nisar
Objectives: Emergence of methicillin resistant Staphylococcus aureus (MRSA) is a major medical problem of current era. These bacteria are resistant to most drugs and rapid diagnosis can provide a clear guideline to clinicians. They possess specific virulence factors and relevant information can be very useful. We designed this study to develop multiplex PCRs to provide rapid information. Methods: We studied 60 Staphylococcus aureus isolates and detected methicillin resistance by cefoxitin sensitivity and targeting of mecA gene...
September 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29138096/one-single-salt-bridge-explains-the-different-cytolytic-activities-shown-by-actinoporins-sticholysin-i-and-ii-from-the-venom-of-stichodactyla-helianthus
#2
Esperanza Rivera-de-Torre, Juan Palacios-Ortega, Sara García-Linares, José G Gavilanes, Álvaro Martínez-Del-Pozo
Sticholysins I and II (StnI and StnII), α-pore forming toxins from the sea anemone Stichodactyla helianthus, are water-soluble toxic proteins which upon interaction with lipid membranes of specific composition bind to the bilayer, extend and insert their N-terminal α-helix, and become oligomeric integral membrane structures. The result is a pore that leads to cell death by osmotic shock. StnI and StnII show 93% of sequence identity, but also different membrane pore-forming activities. The hydrophobicity profile along the first 18 residues revealed differences which were canceled by substituting StnI amino acids 2 and 9...
November 11, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29132006/ocean-acidification-dampens-physiological-stress-response-to-warming-and-contamination-in-a-commercially-important-fish-argyrosomus-regius
#3
Eduardo Sampaio, Ana R Lopes, Sofia Francisco, Jose R Paula, Marta Pimentel, Ana L Maulvault, Tiago Repolho, Tiago F Grilo, Pedro Pousão-Ferreira, António Marques, Rui Rosa
Increases in carbon dioxide (CO2) and other greenhouse gases emissions are changing ocean temperature and carbonate chemistry (warming and acidification, respectively). Moreover, the simultaneous occurrence of highly toxic and persistent contaminants, such as methylmercury, will play a key role in further shaping the ecophysiology of marine organisms. Despite recent studies reporting mostly additive interactions between contaminant and climate change effects, the consequences of multi-stressor exposure are still largely unknown...
November 10, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29127768/diabetic-ketoacidosis-hyperuricemia-and-encephalopathy-intractable-to-regular-dose-insulin
#4
Jillian Gregory, Sonali Basu
BACKGROUND: Diabetic ketoacidosis (DKA) in children less than 1 year of age is a rare occurrence. Typical presentation includes a prodrome of weight loss and polyuria with subsequent presentation to medical care when acidosis becomes symptomatic. CASE PRESENTATION: We describe an unusual case of a previously healthy infant with a 3 days' history of constipation, presenting acutely with abdominal pain, lethargy, and dehydration. On initial evaluation, our patient had profound encephalopathy, with marked tachypnea and work of breathing...
November 11, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29127548/protective-effect-of-agaricus-blazei-polysaccharide-against-cadmium-induced-damage-on-the-testis-of-chicken
#5
Yangyang Song, Ruili Zhang, Hongmei Wang, Yan Yan, Ge Ming
Cadmium (Cd) exposure can cause reproductive toxicity through oxidative stress and inflammatory response. A polysaccharide extract of the edible mushroom Agaricus blazei Murill has been isolated and exhibits antioxidant activity and immunoregulatory effect. The aim of this study was to investigate the protective role of Agaricus blazei polysaccharide (ABP) against Cd-induced damage in chicken testis through enhancing antioxidant activity and alleviating inflammatory response. One hundred twenty healthy 7-day-old Hy-Line male chickens (Harbin, China) were randomly divided into four groups, and each group consisted of 30 chickens: Normal control was fed daily with full feed and 0...
November 10, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/29124121/patients-comorbidities-reduce-the-clinical-value-of-emergency-colonoscopy-results-of-a-retrospective-cohort-study
#6
Cristiano Cremone, Anouk Esch, Charlotte Gagniere, Alessandro Fugazza, Faria Mesli, Michael Levy, Aurelien Amiot, Alexis Laurent, Yann LeBaleur, Francois Hemery, Nicolas De'Angelis, Francesco Brunetti, Iradj Sobhani
Background and study aims:  Urgent endoscopy is often used to diagnose and sometimes treat acute upper gastrointestinal syndromes (hemorrhage, toxic ingestion, and occlusion). However, its suitability concerning the management of lower gastrointestinal conditions in emergency circumstances is controversial. Patients and methods:  We studied the role of emergency colonoscopy in diagnosis and treatment of all consecutive patients presenting with acute lower gastrointestinal symptoms referred to our hospital on an emergency basis...
November 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/29121598/novel-c-terminal-heat-shock-protein-90-inhibitors-ku711-and-ku757-are-effective-in-targeting-head-and-neck-squamous-cell-carcinoma-cancer-stem-cells
#7
C Subramanian, K J Kovatch, M W Sim, G Wang, M E Prince, T E Carey, R Davis, B S J Blagg, M S Cohen
Advanced head and neck squamous cell carcinoma (HNSCC) remains a therapeutic challenge due to the development of therapy resistance. Several studies have implicated the development of cancer stem cells as a possible mechanism for therapy resistance in HNSCC. Heat shock protein 90's (Hsp90's) molecular chaperone function is implicated in pathways of resistance in HNSCC. Therefore, in the present study, we investigated the efficacy of novel C-terminal Hsp90 inhibitors (KU711 and KU757) in targeting HNSCC cancer stem cells (CSCs)...
November 6, 2017: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/29121559/a-screen-printed-paper-microbial-fuel-cell-biosensor-for-detection-of-toxic-compounds-in-water
#8
Jon Chouler, Álvaro Cruz-Izquierdo, Saravanan Rengaraj, Janet L Scott, Mirella Di Lorenzo
Access to safe drinking water is a human right, crucial to combat inequalities, reduce poverty and allow sustainable development. In many areas of the world, however, this right is not guaranteed, in part because of the lack of easily deployable diagnostic tools. Low-cost and simple methods to test water supplies onsite can protect vulnerable communities from the impact of contaminants in drinking water. Ideally such devices would also be easy to dispose of so as to leave no trace, or have a detrimental effect on the environment...
November 6, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29116755/capture-of-cadmium-by-reactive-polysulfides-attenuates-cadmium-induced-adaptive-responses-and-hepatotoxicity
#9
Masahiro Akiyama, Yasuhiro Shinkai, Takamitsu Unoki, Ilseob Shim, Isao Ishii, Yoshito Kumagai
Cadmium (Cd) is an environmental electrophile modifying protein nucleophiles, thereby modulating cellular signaling and toxicity. While reactive persulfides/polysulfides exhibit relatively high nucleophilic properties, their roles in the altered gene expression and toxicity caused by Cd remain unclear. Exposing primary mouse hepatocytes to Cd caused heat shock protein 70 (HSP70) and metallothionein (MT)-I/II to be upregulated and cytotoxicity to occur. These effects were blocked in the presence of polysulfide sodium tetrasulfide (Na2S4)...
November 8, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/29112091/macro-and-microvascular-parameters-following-toxic-shock-syndrome
#10
Katherine Yh Chen, Ling-Jun Li, Tien Y Wong, Carol Y Cheung, Nigel Curtis, Michael Cheung, David P Burgner
Whether individuals who had toxic shock syndrome (TSS) in childhood have differences in macro- and retinal microvascular parameters indicative of increased cardiovascular risk is unknown. We found no evidence of adverse macrovascular changes in 22 TSS participants compared to 60 control participants. Microvascular comparisons showed a reduction in retinal total fractal dimension which has been associated with cardiovascular risk factors in children.
November 3, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29111472/assessment-of-8-hydroxy-2-deoxyguanosine-activity-gene-expression-and-antioxidant-enzyme-activity-on-rainbow-trout-oncorhynchus-mykiss-tissues-exposed-to-biopesticide
#11
Gonca Alak, Arzu Ucar, Veysel Parlak, Aslı Çilingir Yeltekin, Ismail Hakkı Taş, Doğukan Ölmez, Esat Mahmut Kocaman, Mustafa Yılgın, Muhammed Atamanalp, Telat Yanık
The goal of this study was to determinate toxicity mechanism of biopesticide with antioxidant enzymes parameters such as superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) and malondialdehyde (MDA) levels, oxidative DNA damage (8-hydroxy-2-deoxyguanosine (8-OHdG)), transcriptional changes of heat shock protein 70 (HSP70), and cytochromes P4501A (CYP1A), sod, cat, and gpx in liver and gill tissues of Oncorhynchus mykiss. For this aim, plant-based (natural pesticides, azadirachtin (AZA)) and synthetic pesticides (deltamethrin (DLM)) were exposed on the fish at different concentrations (0...
December 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29109702/genomic-comparison-among-lethal-invasive-strains-of-streptococcus-pyogenes-serotype-m1
#12
Gabriel R Fernandes, Aulus E A D Barbosa, Renan N Almeida, Fabíola F Dos S Castro, Marina de C P da Ponte, Celio Faria-Junior, Fernanda M P Müller, Antônio A B Viana, Dario Grattapaglia, Octavio L Franco, Sérgio A Alencar, Simoni C Dias
Streptococcus pyogenes, also known as group A Streptococcus (GAS), is a human pathogen that causes diverse human diseases including streptococcal toxic shock syndrome (STSS). A GAS outbreak occurred in Brasilia, Brazil, during the second half of the year 2011, causing 26 deaths. Whole genome sequencing was performed using Illumina platform. The sequences were assembled and genes were predicted for comparative analysis with emm type 1 strains: MGAS5005 and M1 GAS. Genomics comparison revealed one of the invasive strains that differ from others isolates and from emm 1 reference genomes...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29108905/-maternal-deaths-due-to-infectious-cause-results-from-the-french-confidential-enquiry-into-maternal-deaths-2010-2012
#13
A Rigouzzo, V Tessier, L Zieleskiewicz
Over the period 2010-2012, maternal mortality from infectious causes accounted for 5% of maternal deaths by direct causes and 16% of maternal deaths by indirect causes. Among the 22 deaths caused by infection occurred during this period, 6 deaths were attributed to direct causes from genital tract origin, confirming thus the decrease in direct maternal deaths by infection during the last ten years. On the contrary, indirect maternal deaths by infection, from extragenital origin, doubled during the same period, with 16 deaths in the last triennium, dominated by winter respiratory infections, particularly influenza: the 2009-2010 influenza A (H1N1) virus pandemic was the leading cause of indirect maternal mortality by infection during the studied period...
November 3, 2017: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29107650/molecular-characterization-and-antibiotic-resistance-of-streptococcus-dysgalactiae-subspecies-equisimilis-isolated-from-patients-with-streptococcal-toxic-shock-syndrome
#14
T Ikebe, R Okuno, M Sasaki, Y Kanda, H Otsuka, R Kawahara, H Ohya, M Suzuki, K Uchida, H Nihonmatsu, M Ohnishi
Streptococcal toxic shock syndrome (STSS) is a severe invasive infection characterized by the sudden onset of shock, multiorgan failure, and high mortality. Although STSS is mainly caused by Streptococcus pyogenes, group G streptococcus identified as S. dysgalactiae subsp. equisimilis (SDSE) causing STSS has also been reported; however, no study has analyzed >100 isolates of SDSE causing STSS. Therefore, we characterized the emm genotype of 173 SDSE isolates obtained from STSS patients in Japan during 2014-2016 and performed antimicrobial susceptibility testing using the broth microdilution method and emm gene typing...
October 26, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29103113/testicular-toxicity-and-sperm-quality-following-copper-exposure-in-wistar-albino-rats-ameliorative-potentials-of-l-carnitine
#15
Maurya Khushboo, Meesala Krishna Murthy, Maibam Sunita Devi, Sanasam Sanjeev, Kalibulla Syed Ibrahim, Nachimuthu Senthil Kumar, Vikas Kumar Roy, Guruswami Gurusubramanian
Copper is a persistent toxic and bio-accumulative heavy metal of global concern. Continuous exposure of copper compounds of different origin is the most common form of copper poisoning and in turn adversely altering testis morphology and function and affecting sperm quality. L-carnitine has a vital role in the spermatogenesis, physiology of sperm, sperm production and quality. This study was designed to examine whether the detrimental effects of long-term copper consumption on sperm quality and testis function of Wistar albino rat could be prevented by L-carnitine therapy...
November 4, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29098099/life-threatening-irinotecan-induced-toxicity-in-an-adult-patient-with-alveolar-rhabdomyosarcoma-the-role-of-a-ugt1a1-polymorphism
#16
Arnaud Jannin, Benjamin Hennart, Antoine Adenis, Bruno Chauffert, Nicolas Penel
Alveolar rhabdomyosarcoma (AR) in adult patients is an exceptional malignancy. Management of AR is based on (neo)adjuvant chemotherapy combining ifosfamide, vincristine, and actinomycin D and local curative-intent surgery/radiotherapy. In cases of relapsing AR, the combination of temozolomide/irinotecan is regarded as a possible option. Here we describe life-threatening long-lasting toxicity related to the 1st cycle of irinotecan-based chemotherapy in a 56-year-old woman suffering from locally advanced and metastatic head and neck AR...
2017: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/29097247/emerging-group-c-and-g-streptococcal-endocarditis-a-canadian-perspective
#17
Sylvain A Lother, Davinder S Jassal, Philippe Lagacé-Wiens, Yoav Keynan
OBJECTIVES: We sought to determine the incidence of infective endocarditis (IE) from patients with Group C and G streptococci (GCGS) bacteremia, and characterize the burden of disease, clinical characteristics, and outcomes through a case series of patients with GCGS IE. METHODS: Individuals with blood cultures growing GCGS in Manitoba, Canada, between January 2012 and December 2015 were included. Clinical and echocardiographic parameters were collected retrospectively...
October 30, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29096256/bioaugmentation-of-strain-methylobacterium-sp-c1-towards-p-nitrophenol-removal-with-broad-spectrum-coaggregating-bacteria-in-sequencing-batch-biofilm-reactors
#18
Wenlong Yue, Mei Chen, Zhongqin Cheng, Liqun Xie, Mengying Li
This work was conducted in order to evaluate an instance of bioaugmentation, namely, the addition of a novel p-nitrophenol (PNP)-degrading bacterium Methylobacterium sp. C1 coaggregated with two other broad-spectrum coaggregating strains (Bacillus megaterium T1 and Bacillus cereus G5) within sequence batch biofilm reactors (SBBRs). Results showed that biofilms consisting of C1 and coaggregating bacteria were resistant to shock loads and were more efficient at PNP removal. High-throughput sequencing data revealed that biofilms formed in the presence of the coaggregating bacteria demonstrated greater microbial diversity...
October 20, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29094165/phosphodiesterase-inhibitors-sildenafil-and-vardenafil-reduce-zebrafish-rod-photoreceptor-outer-segment-shedding
#19
Leah J Campbell, Abbie M Jensen
Purpose: The vertebrate rod photoreceptor undergoes daily growth and shedding to renew the rod outer segment (ROS), a modified cilium that contains the phototransduction machinery. It has been demonstrated that ROS shedding is regulated by the light-dark cycle; however, we do not yet have a satisfactory understanding of the molecular mechanisms that underlie this regulation. Given that phototransduction relies on the hydrolysis of cGMP via phosphodiesterase 6 (PDE6), we examined ROS growth and shedding in zebrafish treated with cGMP-specific PDE inhibitors...
November 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29092737/oxalate-nephropathy-following-vitamin-c-intake-within-intensive-care-unit%C3%A2
#20
Eloïse Colliou, Arnaud Mari, Audrey Delas, Antoine Delarche, Stanislas Faguer
OBJECTIVE: To report a case of acute oxalate nephropathy related to vitamin C intake within the intensive care unit (ICU). DESIGN: Case report. SETTING: ICU and nephrology department of a French university hospital. PATIENT: A 57-year-old woman with septic shock related to Legionella pneumophila pneumonia complicated by acute respiratory distress syndrome and acute kidney injury who required renal replacement therapy for 75 days...
October 26, 2017: Clinical Nephrology
keyword
keyword
79180
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"