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https://www.readbyqxmd.com/read/29140569/single-cell-functional-analysis-of-stem-cell-derived-cardiomyocytes-on-micropatterned-flexible-substrates
#1
Jan David Kijlstra, Dongjian Hu, Peter van der Meer, Ibrahim J Domian
Human pluripotent stem-cell derived cardiomyocytes (hPSC-CMs) hold great promise for applications in human disease modeling, drug discovery, cardiotoxicity screening, and, ultimately, regenerative medicine. The ability to study multiple parameters of hPSC-CM function, such as contractile and electrical activity, calcium cycling, and force generation, is therefore of paramount importance. hPSC-CMs cultured on stiff substrates like glass or polystyrene do not have the ability to shorten during contraction, making them less suitable for the study of hPSC-CM contractile function...
November 15, 2017: Current Protocols in Stem Cell Biology
https://www.readbyqxmd.com/read/29139261/-study-on-suitable-distribution-areas-of-sichuan-safflower-in-sichuan-province-based-on-3s-technologies
#2
Wu-Xue Cheng, Guang Dong, Ming-Yan Wu, Lan He, Jia-Li Chen
Sichuan safflower (Carthamus tinctorius) is a traditional Chinese medicine for promoting blood circulation and removing blood stasis. In this paper, taking Sichuan province as an example, based on TM image, digital elevation model (DEM), meteorology, soil and other data, and using remote sensing and GIS technology to extract grassland, elevation, temperature and precipitation, soil and other influencing factors, the spatial distribution of the suitability of safflower was studied, and the field investigation was carried out...
August 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29138745/spontaneous-nervous-system-concussion-in-dogs-a-description-of-two-cases-and-a-review-of-terminology-in-veterinary-medicine
#3
Angelo Pasquale Giannuzzi, Antonio De Simone, Mario Ricciardi
In human medicine, central nervous system (CNS) concussion is defined as a transient neurological dysfunction following a traumatic event, without evidence of structural abnormalities of the affected region on advanced diagnostic imaging. Depending on the anatomical region involved, three forms of concussive syndromes are described: brain concussion, spinal concussion and cerebellar concussion. Although major textbooks of veterinary neurology admit the existence of canine brain concussion, spontaneous cases of this pathological condition have not been reported in small animals so far...
2017: Open veterinary journal
https://www.readbyqxmd.com/read/29138636/stem-cell-tracking-technologies-for-neurological-regenerative-medicine-purposes
#4
REVIEW
Yongtao Zheng, Jiongwei Huang, Tongming Zhu, Ronggang Li, Zhifu Wang, Fukai Ma, Jianhong Zhu
The growing field of stem cell therapy is moving toward clinical trials in a variety of applications, particularly for neurological diseases. However, this translation of cell therapies into humans has prompted a need to create innovative and breakthrough methods for stem cell tracing, to explore the migration routes and its reciprocity with microenvironment targets in the body, to monitor and track the outcome after stem cell transplantation therapy, and to track the distribution and cell viability of transplanted cells noninvasively and longitudinally...
2017: Stem Cells International
https://www.readbyqxmd.com/read/29137611/diagnostic-validity-and-triage-concordance-of-a-physiotherapist-compared-to-physicians-diagnoses-for-common-knee-disorders
#5
S Décary, M Fallaha, B Pelletier, P Frémont, J Martel-Pelletier, J-P Pelletier, D E Feldman, M-P Sylvestre, P-A Vendittoli, F Desmeules
BACKGROUND: Emergence of more autonomous roles for physiotherapists warrants more evidence regarding their diagnostic capabilities. Therefore, we aimed to evaluate diagnostic and surgical triage concordance between a physiotherapist and expert physicians and to assess the diagnostic validity of the physiotherapist's musculoskeletal examination (ME) without imaging. METHODS: This is a prospective diagnostic study where 179 consecutive participants consulting for any knee complaint were independently diagnosed and triaged by two evaluators: a physiotherapist and one expert physician (orthopaedic surgeons or sport medicine physicians)...
November 14, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29135734/cone-beam-computed-tomography-assessment-of-accessory-infraorbital-foramen-and-determination-of-infraorbital-foramen-position
#6
Ibrahim K Ali, Kaustubh Sansare, Freny R Karjodkar, Prashant Salve
There is no evidence about evaluating accessory infraorbital foramen by 3-dimensional analysis like multi slice computed tomography or cone beam computed tomography (CBCT) in human subjects. To authors' best knowledge this is a first study to assess the accessory infraorbital foramen and position of infraorbital foramen in relation to crown of maxillary teeth using CBCT. This study primarily aimed to assess the location and number of accessory infraorbital foramen (AIOF), to measure the distance between main infraorbital foramen and AIOF and secondarily to determine the position of infraorbital foramen in relation to crowns of maxillary second premolar, first molar, and second molar...
November 9, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29135305/choroidal-thickness-of-helicobacter-positive-patients-without-central-serous-chorioretinopathy
#7
Fatih Horozoglu, Ozkan Sever, Ekrem Celik, Rafet Mete, Ertan Sahin
PURPOSE: To evaluate the effect of Helicobacter pylori (H. pylori) infection on subfoveal choroidal thickness (SFCT) in patients without clinical central serous chorioretinopathy (CSC). MATERIALS AND METHODS: This prospective study included 50 patients with pathologically proven H. pylori infection (H. pylori (+)) and 50 patients without H. pylori infection (H. pylori (-)). All of the recruited patients were previously admitted to the Gastroenterology Department of the Namik Kemal University School of Medicine over the period of July 2014 to September 2015...
November 14, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29135224/radiation-responsive-esculin-derived-molecular-gels-as-signal-enhancers-for-optical-imaging
#8
Julian R Silverman, Qize Zhang, Nabendu B Pramanik, Malick Samateh, Travis M Shaffer, Sai Sateesh Sagiri, Jan Grimm, George John
Recent interest in detecting visible photons that emanate from interactions of ionizing radiation with matter have spurred the development of multifunctional materials that amplify this optical signal from radiotracers. Tailored stimuli-responsive systems may be paired with diagnostic radionuclides to improving surgical guidance and aid in detecting therapeutic radionuclides otherwise difficult to image with conventional nuclear medicine approaches. Since light emanating from these interactions is typically low in intensity and blue-weighted (i...
November 14, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29134673/modified-dixon-based-renal-dynamic-contrast-enhanced-mri-facilitates-automated-registration-and-perfusion-analysis
#9
Anneloes de Boer, Tim Leiner, Eva E Vink, Peter J Blankestijn, Cornelis A T van den Berg
PURPOSE: Renal dynamic contrast-enhanced (DCE) MRI provides information on renal perfusion and filtration. However, clinical implementation is hampered by challenges in postprocessing as a result of misalignment of the kidneys due to respiration. We propose to perform automated image registration using the fat-only images derived from a modified Dixon reconstruction of a dual-echo acquisition because these provide consistent contrast over the dynamic series. METHODS: DCE data of 10 hypertensive patients was used...
November 13, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29134367/imaging-of-cardiovascular-disease-in-pregnancy-and-the-peripartum-period
#10
REVIEW
Theodore Pierce, Meline Hovnanian, Sandeep Hedgire, Brian Ghoshhajra
Cardiovascular disease is an important cause of morbidity and mortality during pregnancy and the postpartum period. During pregnancy, the cardiovascular system undergoes extensive hemodynamic, hormonal, and microstructural changes which may exacerbate a preexisting underlying cardiovascular condition or predispose to cardiovascular complications not typically seen in young healthy women. Such conditions include spontaneous coronary artery dissection, atherosclerotic coronary artery disease, and peripartum cardiomyopathy...
November 14, 2017: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29134189/toward-uniform-implementation-of-parametric-map-digital-imaging-and-communication-in-medicine-standard-in-multisite-quantitative-diffusion-imaging-studies
#11
Dariya Malyarenko, Andriy Fedorov, Laura Bell, Melissa Prah, Stefanie Hectors, Lori Arlinghaus, Mark Muzi, Meiyappan Solaiyappan, Michael Jacobs, Maggie Fung, Amita Shukla-Dave, Kevin McManus, Michael Boss, Bachir Taouli, Thomas E Yankeelov, Christopher Chad Quarles, Kathleen Schmainda, Thomas L Chenevert, David C Newitt
This paper reports on results of a multisite collaborative project launched by the MRI subgroup of Quantitative Imaging Network to assess current capability and provide future guidelines for generating a standard parametric diffusion map Digital Imaging and Communication in Medicine (DICOM) in clinical trials that utilize quantitative diffusion-weighted imaging (DWI). Participating sites used a multivendor DWI DICOM dataset of a single phantom to generate parametric maps (PMs) of the apparent diffusion coefficient (ADC) based on two models...
January 2018: Journal of Medical Imaging
https://www.readbyqxmd.com/read/29133818/searching-for-prostate-cancer-by-fully-automated-magnetic-resonance-imaging-classification-deep-learning-versus-non-deep-learning
#12
Xinggang Wang, Wei Yang, Jeffrey Weinreb, Juan Han, Qiubai Li, Xiangchuang Kong, Yongluan Yan, Zan Ke, Bo Luo, Tao Liu, Liang Wang
Prostate cancer (PCa) is a major cause of death since ancient time documented in Egyptian Ptolemaic mummy imaging. PCa detection is critical to personalized medicine and varies considerably under an MRI scan. 172 patients with 2,602 morphologic images (axial 2D T2-weighted imaging) of the prostate were obtained. A deep learning with deep convolutional neural network (DCNN) and a non-deep learning with SIFT image feature and bag-of-word (BoW), a representative method for image recognition and analysis, were used to distinguish pathologically confirmed PCa patients from prostate benign conditions (BCs) patients with prostatitis or prostate benign hyperplasia (BPH)...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29133699/referral-practice-reporting-standards-and-the-impact-of-dopamine-transporter-scans-done-in-a-tertiary-hospital
#13
Shakya Bhattacharjee, Albi J Chalissery, Tim Barry, Donagh O'Sullivan, Martin O'Connell, Timothy Lynch
AIMS: We studied the referral practice, reporting standards, and the impact of 123 ioflupane single photon emission computed tomogram dopamine transporters (DAT-SPECT) scans conducted for the diagnosis and clinical management of patients. SETTINGS AND DESIGNS: The present study was a retrospective, non-interventional study. MATERIALS AND METHODS: We assessed the DAT scan referral and the official reports available from the Nuclear Medicine Department of the Mater Misericordiae University Hospital over 1 year (2013)...
November 2017: Neurology India
https://www.readbyqxmd.com/read/29132573/critical-decisions-in-the-management-of-thoracic-trauma
#14
REVIEW
Morgan Schellenberg, Kenji Inaba
Traumatic injuries to the thorax are common after both blunt and penetrating trauma. Emergency medicine physicians must be able to manage the initial resuscitation and diagnostic workup of these patients. This involves familiarity with a range of radiologic investigations and invasive bedside procedures, including resuscitative thoracotomy. This knowledge is critical to allow for rapid decision making when life-threatening injuries are encountered. This article explores the initial resuscitation and assessment of patients after thoracic trauma, discusses available imaging modalities, reviews frequently performed procedures, and provides an overview of the indications for operative intervention, while emphasizing the critical decision making throughout...
February 2018: Emergency Medicine Clinics of North America
https://www.readbyqxmd.com/read/29130901/quantification-of-fat-fraction-in-lumbar-vertebrae-correlation-with-age-and-implications-for-bone-marrow-dosimetry-in-molecular-radiotherapy
#15
Maikol Salas-Ramirez, Johannes Tran-Gia, Christian Kesenheimer, Andreas Max Weng, Aleksander Kosmala, Anke Heidemeier, Herbert Koestler, Michael Lassmann
Absorbed dose to active bone marrow is a predictor of hematological toxicity in molecular radiotherapy. Due to the complex composition of bone marrow tissue, the necessity to improve the personalized dosimetry has led to the application of non-conventional imaging methods in nuclear medicine. The aim of this study is to apply magnetic resonance imaging (MRI) for quantification of the fat fraction in lumbar vertebrae and to analyze its implications for bone marrow dosimetry. Methods First, a highly accelerated two-point Dixon MRI sequence for fat-water separation was validated in a 3T system against the magnetic resonance spectroscopy (MRS) gold standard...
November 13, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29130515/spectral-decomposition-for-resolving-partial-volume-effects-in-mrsi
#16
Mohammed Z Goryawala, Sulaiman Sheriff, Radka Stoyanova, Andrew A Maudsley
PURPOSE: Estimation of brain metabolite concentrations by MR spectroscopic imaging (MRSI) is complicated by partial volume contributions from different tissues. This study evaluates a method for increasing tissue specificity that incorporates prior knowledge of tissue distributions. METHODS: A spectral decomposition (sDec) technique was evaluated for separation of spectra from white matter (WM) and gray matter (GM), and for measurements in small brain regions using whole-brain MRSI...
November 11, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29130082/a-solid-phase-assisted-approach-for-the-facile-synthesis-of-a-highly-water-soluble-zirconium-89-chelator-for-radiopharmaceutical-development
#17
Manon Briand, Margaret L Aulsebrook, Thomas L Mindt, Gilles Gasser
Nuclear medicine has seen impressive growth in recent years. An important development in this field occurred through the application of new radionuclides, e.g., (89)Zr (t1/2 = 78.4 h, β+ 0.396 MeV), the physical properties of which allow the use of antibodies as biological vectors for specific cancer targeting in combination with high resolution imaging by positron emission tomography (PET). The most commonly used chelator for (89)Zr-based PET imaging is the hexadentate desferrioxamine (DFO) chelator. However, due to the instability of this complex, there has been a strong push towards the development of octadentate chelators...
November 13, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29128344/validity-of-combining-history-elements-and-physical-examination-tests-to-diagnose-patellofemoral-pain
#18
Simon Décary, Pierre Frémont, Bruno Pelletier, Michel Fallaha, Belzile Sylvain, Johanne Martel-Pelletier, Pelletier Jean-Pierre, Debbie Feldman, Sylvestre Marie-Pierre, Pascal-André Vendittoli, François Desmeules
OBJECTIVE: to assess the validity of diagnostic clusters combining history elements and physical examination tests to diagnose or exclude patellofemoral pain (PFP). DESIGN: prospective diagnostic study. SETTINGS: orthopaedic outpatients clinics (n=2), family medicine clinics (n=2) and community-dwelling. PARTICIPANTS: consecutive patients (n=279) consulting one of the participating orthopaedic surgeons (n=3) or sport medicine physicians (n=2) for any knee complaint...
November 8, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29128035/bedside-identification-of-massive-pulmonary-embolism-with-point-of-care-transesophageal-echocardiography
#19
Tomislav Jelic, Melanie Baimel, Jordan Chenkin
BACKGROUND: Pulmonary embolism can be difficult to diagnose, particularly in those who are hemodynamically unstable and cannot be imaged to confirm the diagnosis. Echocardiography can allow for rapid assessment of patients in shock, but requires adequate transthoracic windows to obtain clinically useful information. Emergency physician-performed transesophageal echocardiography (TEE) may be a useful tool when transthoracic echocardiography fails. CASE REPORT: An 86-year-old woman presented to the emergency department after a fall at home...
November 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29128002/update-in-parathyroid-imaging
#20
REVIEW
Samuel J Kuzminski, Julie A Sosa, Jenny K Hoang
Primary hyperparathyroidism (PHPT) is characterized by excessive, dysregulated production of parathyroid hormone (PTH) by 1 or more abnormal parathyroid glands. Minimally invasive surgical techniques have created a need for more precise localization of the parathyroid lesion by imaging. A variety of imaging protocols and techniques have been used for this purpose, but no one modality is clearly superior. Nuclear medicine scintigraphy and ultrasound imaging are established modalities, although multiphase or 4-dimensional computed tomography is an emerging modality with several advantages...
February 2018: Magnetic Resonance Imaging Clinics of North America
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