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https://www.readbyqxmd.com/read/29667143/diagnostic-performance-of-18-f-fdg-pet-ct-and-whole-body-diffusion-weighted-imaging-with-background-body-suppression-dwibs-in-detection-of-lymph-node-and-bone-metastases-from-pediatric-neuroblastoma
#1
Hiroaki Ishiguchi, Shinji Ito, Katsuhiko Kato, Yusuke Sakurai, Hisashi Kawai, Naotoshi Fujita, Shinji Abe, Atsushi Narita, Nobuhiro Nishio, Hideki Muramatsu, Yoshiyuki Takahashi, Shinji Naganawa
OBJECTIVE: Recent many studies have shown that whole body "diffusion-weighted imaging with background body signal suppression" (DWIBS) seems a beneficial tool having higher tumor detection sensitivity without ionizing radiation exposure for pediatric tumors. In this study, we evaluated the diagnostic performance of whole body DWIBS and 18 F-FDG PET/CT for detecting lymph node and bone metastases in pediatric patients with neuroblastoma. METHODS: Subjects in this retrospective study comprised 13 consecutive pediatric patients with neuroblastoma (7 males, 6 females; mean age, 2...
April 17, 2018: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29666972/initial-experience-with-a-sipm-based-pet-ct-scanner-influence-of-acquisition-time-on-image-quality
#2
Ida Sonni, Lucia Baratto, Sonya Park, Negin Hatami, Shyam Srinivas, Guido Davidzon, Sanjiv Sam Gambhir, Andrei Iagaru
BACKGROUND: A newly introduced PET/CT scanner (Discovery Meaningful Insights-DMI, GE Healthcare) includes the silicon photomultiplier (SiPM) with time-of-flight (TOF) technology first used in the GE SIGNA PET/MRI. In this study, we investigated the impact of various acquisition times on image quality using this SiPM-based PET/CT. METHODS: We reviewed data from 58 participants with cancer who were scanned using the DMI PET/CT scanner. The administered dosages ranged 295...
April 18, 2018: EJNMMI Physics
https://www.readbyqxmd.com/read/29666795/cell-chirality-drives-left-right-asymmetric-morphogenesis
#3
REVIEW
Mikiko Inaki, Takeshi Sasamura, Kenji Matsuno
Most macromolecules found in cells are chiral, meaning that they cannot be superimposed onto their mirror image. However, cells themselves can also be chiral, a subject that has received little attention until very recently. In our studies on the mechanisms of left-right (LR) asymmetric development in Drosophila , we discovered that cells can have an intrinsic chirality to their structure, and that this "cell chirality" is generally responsible for the LR asymmetric development of certain organs in this species...
2018: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/29664602/engineering-persistent-luminescence-nanoparticles-for-biological-applications-from-biosensing-bioimaging-to-theranostics
#4
Shao-Kai Sun, He-Fang Wang, Xiu-Ping Yan
Persistent luminescence nanoparticles (PLNPs) are unique optical materials emitting long-lasting luminescence after ceasing excitation. Such a unique optical feature allows luminescence detection without constant external illumination to avoid the interferences of autofluorescence and scattering light from biological fluids and tissues. Besides, near-infrared (NIR) PLNPs have advantages of deep penetration and the reactivation of the persistent luminescence (PL) by red or NIR light. These features make the application of NIR-emitting PLNPs in long-term bioimaging no longer limited by the lifetime of PL...
April 17, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29664223/chondrogenic-response-in-presence-of-cartilage-extracellular-matrix-nanoparticles
#5
Saeed Zahiri, Elahe Masaeli, Elahe Poorazizi, Mohammad Hossein Nasr-Esfahani
Current studies based on regenerative medicine suggest, decellularized extracellular matrix (DC-ECM) components can regulate cell phenotype. In this regard, it is believed, presence of cartilage extracellular matrix particles in culture condition could produce physical and biochemical supportive cues for chondrogenesis. In this study, DC-ECM nanoparticles with average size of 61.5± 22.4 nm were produced by decellularization and mechanical processing. Homogenous distribution and nano scale size of yield particles were observed by Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM) microscopy imaging...
April 17, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29663673/developing-the-digital-kyoto-collection-in-education-and-research
#6
Mark Anthony Hill
The Kyoto embryo collection was begun in 1961 by Dr. Hideo Nishimura. The collection has been continuously developed and currently contains over 44,000 human normal and abnormal specimens. Beginning online in 1997, the internet provided an opportunity to make embryos from the collection widely available for research and educational purposes (http://tiny.cc/Embryo). These embryonic development resources have been continuously published and available from that time until today. Published in Japanese as an Atlas of Embryonic Development...
April 16, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29663461/the-legal-frameworks-that-govern-fetal-surgery-in-the-united-kingdom-european-union-and-the-united-states
#7
REVIEW
Kevin X Cao, Alice Booth, Sebastien Ourselin, Anna L David, Richard Ashcroft
The specialty of fetal surgery or fetal intervention is one of the most exciting emerging fields of modern medicine. It is made possible by decades of major developments in antenatal imaging, obstetric anaesthesia, fetal medicine, paediatric surgery and of course by the bold and novel practitioners willing to take new steps to advance the field. Beginning in the 1970s it has now reached a stage of maturity where there are several established in-utero procedures and countless clinical trials and studies to develop more...
April 16, 2018: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29662559/deep-learning-in-nuclear-medicine-and-molecular-imaging-current-perspectives-and-future-directions
#8
REVIEW
Hongyoon Choi
Recent advances in deep learning have impacted various scientific and industrial fields. Due to the rapid application of deep learning in biomedical data, molecular imaging has also started to adopt this technique. In this regard, it is expected that deep learning will potentially affect the roles of molecular imaging experts as well as clinical decision making. This review firstly offers a basic overview of deep learning particularly for image data analysis to give knowledge to nuclear medicine physicians and researchers...
April 2018: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29662558/radiomics-as-a-quantitative-imaging-biomarker-practical-considerations-and-the-current-standpoint-in-neuro-oncologic-studies
#9
REVIEW
Ji Eun Park, Ho Sung Kim
Radiomics utilizes high-dimensional imaging data to discover the association with diagnostic, prognostic, predictive endpoint or radiogenomics. It is an emerging field of study that potentially depicts the intratumoral heterogeneity from quantitative and classified high-throughput data. The radiomics approach has an analytic pipeline where the imaging features are extracted, processed and analyzed. At this point, special data handling is essential because it faces issues of a high-dimensional biomarker compared to a single biomarker approach...
April 2018: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29662557/ct-radiomics-in-thoracic-oncology-technique-and-clinical-applications
#10
REVIEW
Geewon Lee, So Hyeon Bak, Ho Yun Lee
Precision medicine offers better treatment options and improved survival for cancer patients based on individual variability. As the success of precision medicine depends on robust biomarkers, the requirement for improved imaging biomarkers that reflect tumor biology has grown exponentially. Radiomics, the field of study in which high-throughput data are generated and large amounts of advanced quantitative features are extracted from medical images, has shown great potential as a source of quantitative biomarkers in the field of oncology...
April 2018: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29662316/metformin-inhibits-proliferation-and-cytotoxicity-and-induces-apoptosis-via-ampk-pathway-in-cd19-chimeric-antigen-receptor-modified-t-cells
#11
Qian Mu, Miao Jiang, Yuzhu Zhang, Fei Wu, Hui Li, Wen Zhang, Fang Wang, Jiang Liu, Liang Li, Dongshan Wang, Wenjuan Wang, Shiwu Li, Haibo Song, Dongqi Tang
Background: CD19-chimericantigen receptor (CAR) modified T cells (CD19-CAR T cells) have been well documented to possess potent anti-tumor properties against CD19-expressingleukemia cells. As a traditional medicine, metformin has been widely used to treat type II diabetes mellitus and more recently has become a candidate for the treatment of cancer. However, no report has revealed the direct effect of metformin on CD19-CAR T cell biological function and its underling mechanisms. Purpose: The purpose of this research was to explore the effect of metformin on CD19-CAR T cell biological function and the mechanisms involved...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29662077/pharmacodynamics-of-mutant-idh1-inhibitors-in-glioma-patients-probed-by-in-vivo-3d-mrs-imaging-of-2-hydroxyglutarate
#12
Ovidiu C Andronesi, Isabel C Arrillaga-Romany, K Ina Ly, Wolfgang Bogner, Eva M Ratai, Kara Reitz, A John Iafrate, Jorg Dietrich, Elizabeth R Gerstner, Andrew S Chi, Bruce R Rosen, Patrick Y Wen, Daniel P Cahill, Tracy T Batchelor
Inhibitors of the mutant isocitrate dehydrogenase 1 (IDH1) entered recently in clinical trials for glioma treatment. Mutant IDH1 produces high levels of 2-hydroxyglurate (2HG), thought to initiate oncogenesis through epigenetic modifications of gene expression. In this study, we show the initial evidence of the pharmacodynamics of a new mutant IDH1 inhibitor in glioma patients, using non-invasive 3D MR spectroscopic imaging of 2HG. Our results from a Phase 1 clinical trial indicate a rapid decrease of 2HG levels by 70% (CI 13%, P = 0...
April 16, 2018: Nature Communications
https://www.readbyqxmd.com/read/29661520/utilization-trends-in-diagnostic-imaging-for-a-commercially-insured-population-a-study-of-massachusetts-residents-2009-to-2013
#13
Stephen Flaherty, Koenraad J Mortele, Gary J Young
PURPOSE: To report utilization trends in diagnostic imaging among commercially insured Massachusetts residents from 2009 to 2013. MATERIALS AND METHODS: Current Procedural Terminology codes were used to identify diagnostic imaging claims in the Massachusetts All-Payer Claims Database for the years 2009 to 2013. We reported utilization and spending annually by imaging modality using total claims, claims per 1,000 individuals, total expenditures, and average per claim payments...
April 13, 2018: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29660210/anions-reversibly-responsive-luminescent-tb-iii-nanocellulose-complex-hydrogels-for-latent-fingerprint-detection-and-encryption
#14
Jun Hai, Tianrong Li, Junxia Su, Wensheng Liu, Yanmin Ju, Baodui Wang, Yanglong Hou
Fingerprint fluorescence imaging has become one of the most prominent technologies in the field of forensic medicine, but it seldom considers the security protection of detection information, which is of great importance in modern society. Here we demonstrate that ClO-/SCN- reversibly responsive luminescent Tb(III) carboxymethyl-cellulose (CMC) complex-binding aptamer hydrogels can be used to realize selective detection, protection, and storage of fingerprint information. The imaging information of the fingerprint can be quenched and recovered by using ClO-/SCN- regulation, respectively, resulting in reversible on/off conversion of the luminescent signals in the process of encryption and decryption of multiple information...
April 16, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29658792/scandium-and-terbium-radionuclides-for-radiotheranostics-current-state-of-development-towards-clinical-application
#15
Cristina Müeller, Katharina A Domnanich, Christoph A Umbricht, Nicholas P van der Meulen
Currently, different radiometals are in use for imaging and therapy in nuclear medicine: 68 Ga and 111 In are examples of nuclides for positron emission tomography (PET) and single photon emission computed tomography (SPECT), respectively, while 177 Lu and 225 Ac are used for β- - and α-radionuclide therapy. The application of diagnostic and therapeutic radionuclides of the same element (radioisotopes) would utilize chemically-identical radiopharmaceuticals for imaging and subsequent treatment, thereby enabling the radiotheranostic concept...
April 16, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29658536/-education-motivations-and-working-conditions-of-a-cohort-of-nurses-attending-to-an-open-competition
#16
Roberto Accardi, Silvia Pazzaglia, Antonella Demarchi, Barbara Sappa, Dario Laquintana
. Education, motivations and working conditions of a cohort of nurses attending to an open-competition. INTRODUCTION: In the last decade, the progressive reduction of staff turnover decreased together with the number of open competitions, now attended by thousands of candidates, portraying an image of massive unemployment in the nursing profession. AIM: To describe the socio-demographic profile, the studies, previous work experiences and motivations of a cohort of nurses participats a maxi-competition in Lombardy region...
January 2018: Assistenza Infermieristica e Ricerca: AIR
https://www.readbyqxmd.com/read/29657900/occipital-and-cingulate-hypometabolism-are-significantly-under-reported-on-18-fluorodeoxyglucose-positron-emission-tomography-scans-of-patients-with-lewy-body-dementia
#17
Moath Hamed, Frank Schraml, Jeffrey Wilson, James Galvin, Marwan N Sabbagh
Objective: To determine whether occipital and cingulate hypometabolism is being under-reported or missed on 18-fluorodeoxyglucose positron emission tomography (FDG-PET) CT scans in patients with Dementia with Lewy Bodies (DLB). Background: Recent studies have reported higher sensitivity and specificity for occipital and cingulate hypometabolism on FDG-PET of DLB patients. Methods: This retrospective chart review looked at regions of interest (ROI's) in FDG-PET CT scan reports in 35 consecutive patients with a clinical diagnosis of probable, possible, or definite DLB as defined by the latest DLB Consortium Report...
2018: Journal of Alzheimer's Disease and Parkinsonism
https://www.readbyqxmd.com/read/29657576/high-speed-optical-coherence-tomography-by-circular-interferometric-ranging
#18
Meena Siddiqui, Ahhyun S Nam, Serhat Tozburun, Norman Lippok, Cedric Blatter, Benjamin J Vakoc
Existing three-dimensional optical imaging methods excel in controlled environments but are difficult to deploy over large, irregular and dynamic fields. This has limited imaging in areas such as material inspection and medicine. To better address these applications, we developed methods in optical coherence tomography (OCT) to efficiently interrogate sparse scattering fields, i.e., those in which most locations (voxels) do not generate meaningful signal. Frequency comb sources are used to superimpose reflected signals from equispaced locations through optical subsampling...
2018: Nature Photonics
https://www.readbyqxmd.com/read/29657459/stress-radiographs-for-evaluating-acromioclavicular-joint-separations-in-an-active-duty-patient-population-what-have-we-learned
#19
K Aaron Shaw, John Synovec, Josef Eichinger, Christopher J Tucker, Jason A Grassbaugh, Stephen A Parada
Introduction: Acromioclavicular (AC) joint separation is a common entity in athletic patient populations. The surgical treatment of these injuries varies based upon extent of injury, with numerous imaging modalities recommended to differentiate injury severity and treatment options. The use of weighted stress radiographs is controversial in the diagnostic evaluation of AC separation with previous consensus recommending against their use. No study to date has investigated the clinical utilization of diagnostic studies in the evaluation of AC joint separations in a military surgeon population...
March 2018: Journal of Orthopaedics
https://www.readbyqxmd.com/read/29656662/beneficial-effects-of-salvia-miltiorrhiza-in-the-healing-of-burn-wounds-an-experimental-study-in-rats
#20
Fatih Irmak, Sevgi Kurt Yazar, Serhat Selami Şirvan, Merdan Serin, Ayşim Özağarı, Ayşin Karasoy Yeşilada
INTRODUCTION: Burn healing is a complicated process and very few treatments can positively alter its effects. The aim of this study was to investigate the effects Salvia miltiorrhiza (SM -Danshen), a traditional Chinese medicine, on burn wound healing. MATERIAL AND METHODS: Twenty rats were included in this study and divided into two groups. 3 × 2 cm wide burn areas were created in the dorsal skin of all the animals with thermal contact. Intraoral 1 ml/day saline and 1 g/kg/day SM were given in control and experiment groups, respectively...
April 14, 2018: Journal of Plastic Surgery and Hand Surgery
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