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https://www.readbyqxmd.com/read/28918355/gallium-iii-chelates-of-mixed-phosphonate-carboxylate-triazamacrocyclic-ligands-relevant-to-nuclear-medicine-structural-stability-and-in-vivo-studies
#1
Maria I M Prata, João P André, Zoltán Kovács, Anett I Takács, Gyula Tircsó, Imre Tóth, Carlos F G C Geraldes
Three triaza macrocyclic ligands, H6NOTP (1,4,7-triazacyclononane-N,N',N″-trimethylene phosphonic acid), H4NO2AP (1,4,7-triazacyclononane-N-methylenephosphonic acid-N',N″-dimethylenecarboxylic acid), and H5NOA2P (1,4,7-triazacyclononane-N,N'-bis(methylenephosphonic acid)-N″-methylene carboxylic acid), and their gallium(III) chelates were studied in view of their potential interest as scintigraphic and PET (Positron Emission Tomography) imaging agents. A (1)H, (31)P and (71)Ga multinuclear NMR study gave an insight on the structure, internal dynamics and stability of the chelates in aqueous solution...
September 1, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28917501/personalized-translational-epilepsy-research-novel-approaches-and-future-perspectives-part-i-clinical-and-network-analysis-approaches
#2
REVIEW
Felix Rosenow, Natascha van Alphen, Albert Becker, Andreas Chiocchetti, Ralf Deichmann, Thomas Deller, Thomas Freiman, Christine M Freitag, Johannes Gehrig, Anke M Hermsen, Peter Jedlicka, Christian Kell, Karl Martin Klein, Susanne Knake, Dimitri M Kullmann, Stefan Liebner, Braxton A Norwood, Diana Omigie, Karlheinz Plate, Andreas Reif, Philipp S Reif, Yvonne Reiss, Jochen Roeper, Michael W Ronellenfitsch, Stephanie Schorge, Gerhard Schratt, Stephan W Schwarzacher, Joachim P Steinbach, Adam Strzelczyk, Jochen Triesch, Marlies Wagner, Matthew C Walker, Frederic von Wegner, Sebastian Bauer
Despite the availability of more than 15 new "antiepileptic drugs", the proportion of patients with pharmacoresistant epilepsy has remained constant at about 20-30%. Furthermore, no disease-modifying treatments shown to prevent the development of epilepsy following an initial precipitating brain injury or to reverse established epilepsy have been identified to date. This is likely in part due to the polyetiologic nature of epilepsy, which in turn requires personalized medicine approaches. Recent advances in imaging, pathology, genetics and epigenetics have led to new pathophysiological concepts and the identification of monogenic causes of epilepsy...
September 13, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28917498/personalized-translational-epilepsy-research-novel-approaches-and-future-perspectives-part-ii-experimental-and-translational-approaches
#3
REVIEW
Sebastian Bauer, Natascha van Alphen, Albert Becker, Andreas Chiocchetti, Ralf Deichmann, Thomas Deller, Thomas Freiman, Christine M Freitag, Johannes Gehrig, Anke M Hermsen, Peter Jedlicka, Christian Kell, Karl Martin Klein, Susanne Knake, Dimitri M Kullmann, Stefan Liebner, Braxton A Norwood, Diana Omigie, Karlheinz Plate, Andreas Reif, Philipp S Reif, Yvonne Reiss, Jochen Roeper, Michael W Ronellenfitsch, Stephanie Schorge, Gerhard Schratt, Stephan W Schwarzacher, Joachim P Steinbach, Adam Strzelczyk, Jochen Triesch, Marlies Wagner, Matthew C Walker, Frederic von Wegner, Felix Rosenow
Despite the availability of more than 15 new "antiepileptic drugs", the proportion of patients with pharmacoresistant epilepsy has remained constant at about 20-30%. Furthermore, no disease-modifying treatments shown to prevent the development of epilepsy following an initial precipitating brain injury or to reverse established epilepsy have been identified to date. This is likely in part due to the polyetiologic nature of epilepsy, which in turn requires personalized medicine approaches. Recent advances in imaging, pathology, genetics, and epigenetics have led to new pathophysiological concepts and the identification of monogenic causes of epilepsy...
September 13, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28916930/tongue-image-analysis-and-its-mobile-app-development-for-health-diagnosis
#4
Ratchadaporn Kanawong, Tayo Obafemi-Ajayi, Dahai Liu, Meng Zhang, Dong Xu, Ye Duan
Computer-aided diagnosis provides a medical procedure that assists physicians in interpretation of medical images. This work focuses on computer-aided tongue image analysis specifically, based on Traditional Chinese Medicine (TCM). Tongue diagnosis is an important component of TCM. Computerized tongue diagnosis can aid medical practitioners in capturing quantitative features to improve reliability and consistency of diagnosis. Recently, researchers have started to develop computer-aided tongue analysis algorithms based on new advancement in digital photogrammetry, image analysis, and pattern recognition technologies...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28916881/a-3d-mammometric-comparison-of-implant-based-breast-reconstruction-with-and-without-acellular-dermal-matrix-adm
#5
Cynthia Tsay, Victor Zhu, Tracy Sturrock, Ajul Shah, Stephanie Kwei
This retrospective study utilizes 3D imaging and mammometrics to compare implant-based breast reconstruction with and without the use of ADM. Previous studies have suggested improved aesthetic outcomes with the use of ADM, but none have been able to quantify this difference. Images were obtained at early and late time points following the expander-implant exchange procedure. Measurements included the point of maximum projection, the superior, inferior, medial and lateral volumetric distribution, and the distance from the point of maximum projection to the inframammary fold along the breast meridian...
September 15, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28916593/carnosic-acid-and-carnosol-two-major-antioxidants-of-rosemary-act-through-different-mechanisms
#6
Margot Loussouarn, Anja Krieger-Liszkay, Ljubica Svilar, Antoine Bily, Simona Birtic, Michel Havaux
Carnosic acid, a phenolic diterpene specific of the Lamiaceae family, is highly abundant in rosemary species. Despite numerous industrial and medicinal/pharmaceutical applications of its antioxidative features, this compound in planta and its antioxidant mechanism have received little attention, except a few studies of rosemary plants under natural conditions. In vitro analyses, using HPLC-UV and luminescence imaging, revealed that carnosic acid and its major oxidized derivative, carnosol, protect lipids from oxidation...
September 15, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28915974/rapid-and-accurate-intraoperative-pathological-diagnosis-by-artificial-intelligence-with-deep-learning-technology
#7
Jing Zhang, Yanlin Song, Fan Xia, Chenjing Zhu, Yingying Zhang, Wenpeng Song, Jianguo Xu, Xuelei Ma
Frozen section is widely used for intraoperative pathological diagnosis (IOPD), which is essential for intraoperative decision making. However, frozen section suffers from some drawbacks, such as time consuming and high misdiagnosis rate. Recently, artificial intelligence (AI) with deep learning technology has shown bright future in medicine. We hypothesize that AI with deep learning technology could help IOPD, with a computer trained by a dataset of intraoperative lesion images. Evidences supporting our hypothesis included the successful use of AI with deep learning technology in diagnosing skin cancer, and the developed method of deep-learning algorithm...
September 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28914269/looking-beyond-the-exome-a-phenotype-first-approach-to-molecular-diagnostic-resolution-in-rare-and-undiagnosed-diseases
#8
Loren D M Pena, Yong-Hui Jiang, Kelly Schoch, Rebecca C Spillmann, Nicole Walley, Nicholas Stong, Sarah Rapisardo Horn, Jennifer A Sullivan, Allyn McConkie-Rosell, Sujay Kansagra, Edward C Smith, Mays El-Dairi, Jane Bellet, Martha Ann Keels, Joan Jasien, Peter G Kranz, Richard Noel, Shashi K Nagaraj, Robert K Lark, Daniel S G Wechsler, Daniela Del Gaudio, Marco L Leung, Laura G Hendon, Collette C Parker, Kelly L Jones, David B Goldstein, Vandana Shashi
PurposeTo describe examples of missed pathogenic variants on whole-exome sequencing (WES) and the importance of deep phenotyping for further diagnostic testing.MethodsGuided by phenotypic information, three children with negative WES underwent targeted single-gene testing.ResultsIndividual 1 had a clinical diagnosis consistent with infantile systemic hyalinosis, although WES and a next-generation sequencing (NGS)-based ANTXR2 test were negative. Sanger sequencing of ANTXR2 revealed a homozygous single base pair insertion, previously missed by the WES variant caller software...
September 14, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28914065/-the-image-of-a%C3%A2-good-pharmacist-in-the-works-of-saladin-di-ascoli-and-valerius-cordus
#9
Anton Bartunek, František Šimon
Separation of pharmacy from medicine induced the requirements formulation for an ideal pharmacist. Two prominent authors did so, Saladin di Ascoli (the first half of the XVth century) in the work Compendium aromatariorum (1488) and Valerius Cordus (1515-1544) in the work Dispensatorium pharmacopolarum (1546). Both of them formulate similar postulates of both professional and ethical nature, namely a knowledge of Latin, good education, experience, good character traits, need of satisfied marriage; both say that the pharmacist is required to be a good Christian, they condemn alcohol, relationships with women, poisons and abortifacients, remember right relationship to money...
2017: Ceská a Slovenská Farmacie
https://www.readbyqxmd.com/read/28913930/accuracy-repeatability-and-interplatform-reproducibility-of-t1-quantification-methods-used-for-dce-mri-results-from-a-multicenter-phantom-study
#10
Octavia Bane, Stefanie J Hectors, Mathilde Wagner, Lori L Arlinghaus, Madhava P Aryal, Yue Cao, Thomas L Chenevert, Fiona Fennessy, Wei Huang, Nola M Hylton, Jayashree Kalpathy-Cramer, Kathryn E Keenan, Dariya I Malyarenko, Robert V Mulkern, David C Newitt, Stephen E Russek, Karl F Stupic, Alina Tudorica, Lisa J Wilmes, Thomas E Yankeelov, Yi-Fei Yen, Michael A Boss, Bachir Taouli
PURPOSE: To determine the in vitro accuracy, test-retest repeatability, and interplatform reproducibility of T1 quantification protocols used for dynamic contrast-enhanced MRI at 1.5 and 3 T. METHODS: A T1 phantom with 14 samples was imaged at eight centers with a common inversion-recovery spin-echo (IR-SE) protocol and a variable flip angle (VFA) protocol using seven flip angles, as well as site-specific protocols (VFA with different flip angles, variable repetition time, proton density, and Look-Locker inversion recovery)...
September 14, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28913879/short-t2-imaging-using-a-3d-double-adiabatic-inversion-recovery-prepared-ultrashort-echo-time-cones-3d-dir-ute-cones-sequence
#11
Ya-Jun Ma, Yanchun Zhu, Xing Lu, Michael Carl, Eric Y Chang, Jiang Du
PURPOSE: To investigate high contrast imaging of short T2 tissues with a three-dimensional double adiabatic inversion recovery prepared ultrashort echo time Cones (3D DIR-UTE-Cones) sequence. METHODS: The sequence used two sequential adiabatic inversion pulses to suppress signals from long T2 tissues, followed by multispoke UTE acquisition to detect signals from short T2 tissues. The two adiabatic inversion pulses are identical with a center frequency located at the water peak, but the spectral width is broad enough to cover both water and fat frequencies...
September 14, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28913838/simultaneous-acquisition-of-perfusion-image-and-dynamic-mr-angiography-using-time-encoded-pseudo-continuous-asl
#12
Yuriko Suzuki, Michael Helle, Peter Koken, Marc Van Cauteren, Matthias J P van Osch
PURPOSE: Both dynamic magnetic resonance angiography (4D-MRA) and perfusion imaging can be acquired by using arterial spin labeling (ASL). While 4D-MRA highlights large vessel pathology, such as stenosis or collateral blood flow patterns, perfusion imaging provides information on the microvascular status. Therefore, a complete picture of the cerebral hemodynamic condition could be obtained by combining the two techniques. Here, we propose a novel technique for simultaneous acquisition of 4D-MRA and perfusion imaging using time-encoded pseudo-continuous arterial spin labeling...
September 14, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28913157/non-functioning-gastroenteropancreatic-gep-tumors-a-111-in-pentetreotide-spect-ct-diagnostic-study
#13
Angela Spanu, Orazio Schillaci, Bastiana Piras, Diego F Calvisi, Antonio Falchi, Roberta Danieli, Susanna Nuvoli, Franca Dore, Giuseppe Madeddu
In a retrospective study performed in non-functioning GEP tumor patients we further investigated (111)In-Pentetreotide SPECT/CT usefulness in diagnosis, staging and follow-up also evaluating whether the procedure may give more information than conventional imaging procedures (CIP), such as CT, MRI, US. We enrolled 104 consecutive patients with non-functioning GEP tumors, 30 in initial diagnosis and staging phases (IDS) and 74 in follow-up (FU). All patients underwent somatostatin receptor scintigraphy (SRS) whole body scan at 4, 24 and, if necessary, 48 hours followed by abdominal and chest SPECT/CT after (111)In-Pentetreotide 148-222 MBq i...
2017: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28913156/head-and-neck-pet-ct-therapy-response-interpretation-criteria-hopkins-criteria-external-validation-study
#14
Ayse Tuba Kendi, David Brandon, Jeffrey Switchenko, Jeffery Trad Wadsworth, Mark W El-Deiry, Nabil F Saba, David M Schuster, Rathan M Subramaniam
Qualitative assessment of PET/CT results in post therapy is very important to provide a reproducible and systemic reporting. A recently introduced response criteria, known as the Hopkins criteria showed promising results. Our aim is to externally validate the Hopkins interpretation system to assess therapy response in head and neck squamous cell cancer (HNSCC). The study included 69 biopsy proven HNSCC patients who underwent post therapy PET/CT between 5-24 weeks after completion of therapy. PET/CT images were interpreted by one nuclear medicine physician and one nuclear radiologist, independently...
2017: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28912940/technical-report-on-the-modification-of-3-dimensional-non-contact-human-body-laser-scanner-for-the-measurement-of-anthropometric-dimensions-verification-of-its-accuracy-and-precision
#15
Akram Sadat Jafari Roodbandi, Hamid Naderi, Naser Hashenmi-Nejad, Alireza Choobineh, Mohammad Reza Baneshi, Vafa Feyzi
Introduction: Three-dimensional (3D) scanners are widely used in medicine. One of the applications of 3D scanners is the acquisition of anthropometric dimensions for ergonomics and the creation of an anthropometry data bank. The aim of this study was to evaluate the precision and accuracy of a modified 3D scanner fabricated in this study. Methods: In this work, a 3D scan of the human body was obtained using DAVID Laser Scanner software and its calibration background, a linear low-power laser, and one advanced webcam...
2017: Journal of Lasers in Medical Sciences
https://www.readbyqxmd.com/read/28911214/growth-regulation-by-estrogen-in-breast-cancer-1-greb1-is-a-novel-progesterone-responsive-gene-required-for-human-endometrial-stromal-decidualization
#16
Alison J Camden, Maria M Szwarc, Sangappa B Chadchan, Francesco J DeMayo, Bert W O'Malley, John P Lydon, Ramakrishna Kommagani
STUDY QUESTION: Is Growth Regulation by Estrogen in Breast Cancer 1 (GREB1) required for progesterone-driven endometrial stromal cell decidualization? SUMMARY ANSWER: GREB1 is a novel progesterone-responsive gene required for progesterone-driven human endometrial stromal cell (HESC) decidualization. WHAT IS KNOWN ALREADY: Successful establishment of pregnancy requires HESCs to transform from fibroblastic to epithelioid cells in a process called decidualization...
September 1, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28910997/paediatric-nuclear-medicine-imaging
#17
Lorenzo Biassoni, Marina Easty
Background: Nuclear medicine imaging explores tissue viability and function by using radiotracers that are taken up at cellular level with different mechanism. This imaging technique can also be used to assess blood flow and transit through tubular organs. Nuclear medicine imaging has been used in paediatrics for decades and this field is continuously evolving. Sources of data: The data presented comes from clinical experience and some milestone papers on the subject...
September 1, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/28910912/-percutaneous-catheterization-for-extracorporeal-membrane-oxygenation-a-retrospective-case-series
#18
X Y Li, H Y He, X Tang, R Wang, C Y Zhang, S Q Wang, B Sun, Z H Tong
Objective: To review the experience of percutaneous catheterization for extracorporeal membrane oxygenation (ECMO) by respiratory intensivists at a single institution. Methods: A retrospective review of 87 patients undergoing percutaneous catheterization for ECMO in Department of Respiratory and Critical Care Medicine of Beijing Chaoyang Hospital from November 2009 to January 2017. Subject demographics, type of support, cannulation configuration, types of cannulas, use of imaging modalities, and complications were recorded and summarized...
September 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28910834/-imaging-in-clinic-and-research-contribution-to-individualized-medicine
#19
Otmar Schober, Olaf Dössel, Helmut Ermert, Hermann Requardt, Sibylle Ziegler, Gerhard Adam
No abstract text is available yet for this article.
October 2017: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/28906462/time-resolved-diffuse-optical-spectroscopy-and-imaging-using-solid-state-detectors-characteristics-present-status-and-research-challenges
#20
REVIEW
Mrwan Alayed, M Jamal Deen
Diffuse optical spectroscopy (DOS) and diffuse optical imaging (DOI) are emerging non-invasive imaging modalities that have wide spread potential applications in many fields, particularly for structural and functional imaging in medicine. In this article, we review time-resolved diffuse optical imaging (TR-DOI) systems using solid-state detectors with a special focus on Single-Photon Avalanche Diodes (SPADs) and Silicon Photomultipliers (SiPMs). These TR-DOI systems can be categorized into two types based on the operation mode of the detector (free-running or time-gated)...
September 14, 2017: Sensors
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