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"Kenneth Wang"

Iraad F Bronner, Thomas D Otto, Min Zhang, Kenneth Udenze, Chengqi Wang, Michael A Quail, Rays H Y Jiang, John H Adams, Julian C Rayner
Genetic screening using random transposon insertions has been a powerful tool for uncovering biology in prokaryotes, where whole-genome saturating screens have been performed in multiple organisms. In eukaryotes, such screens have proven more problematic, in part because of the lack of a sensitive and robust system for identifying transposon insertion sites. We here describe quantitative insertion-site sequencing, or QIseq, which uses custom library preparation and Illumina sequencing technology and is able to identify insertion sites from both the 5' and 3' ends of the transposon, providing an inbuilt level of validation...
July 2016: Genome Research
Emma Colvill, Jeremy Booth, Simeon Nill, Martin Fast, James Bedford, Uwe Oelfke, Mitsuhiro Nakamura, Per Poulsen, Esben Worm, Rune Hansen, Thomas Ravkilde, Jonas Scherman Rydhög, Tobias Pommer, Per Munck Af Rosenschold, Stephanie Lang, Matthias Guckenberger, Christian Groh, Christian Herrmann, Dirk Verellen, Kenneth Poels, Lei Wang, Michael Hadsell, Thilo Sothmann, Oliver Blanck, Paul Keall
PURPOSE: A study of real-time adaptive radiotherapy systems was performed to test the hypothesis that, across delivery systems and institutions, the dosimetric accuracy is improved with adaptive treatments over non-adaptive radiotherapy in the presence of patient-measured tumor motion. METHODS AND MATERIALS: Ten institutions with robotic(2), gimbaled(2), MLC(4) or couch tracking(2) used common materials including CT and structure sets, motion traces and planning protocols to create a lung and a prostate plan...
April 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
M Zhang, Q Lu, B Egan, X-B Zhong, K Brandt, J Wang
OBJECTIVE: Abnormal metabolic activities of chondrocytes may cause articular cartilage (AC) degradation, but key transcription factors regulating metabolic activities in AC of aging individuals remain unknown. This study aimed to investigate the role of transcription factor NFAT1 in regulating the expression of anabolic and catabolic molecules in AC of aged mice. METHODS: The hip, knee, and shoulder joints of BALB/c mice were harvested at 6, 12, 15, 18, and 24 months of age for histopathological and immunohistochemical (IHC) analyses...
July 2016: Osteoarthritis and Cartilage
Hui Liu, Wei Liu, Ying Lin, Teng Liu, Zhaowu Ma, Mo Li, Hong-Mei Zhang, Qing Kenneth Wang, An-Yuan Guo
Scoring the correlation between two genes by their shared properties is a common and basic work in biological study. A prospective way to score this correlation is to quantify the overlap between the two sets of homogeneous properties of the two genes. However the proper model has not been decided, here we focused on studying the quantification of overlap and proposed a more effective model after theoretically compared 7 existing models. We defined three characteristic parameters (d, R, r) of an overlap, which highlight essential differences among the 7 models and grouped them into two classes...
2015: Scientific Reports
Harry R Chobanian, Barbara Pio, Yan Guo, Hong Shen, Mark A Huffman, Maria Madeira, Gino Salituro, Jenna L Terebetski, James Ormes, Nina Jochnowitz, Lizbeth Hoos, Yuchen Zhou, Dale Lewis, Brian Hawes, Lyndon Mitnaul, Kim O'Neill, Kenneth Ellsworth, Liangsu Wang, Tesfaye Biftu, Joseph L Duffy
Modification of the previously disclosed (S)-N-(2-(aminomethyl)-5-chlorobenzyl)-1-((R)-2-hydroxy-3,3-dimethylbutanoyl)pyrrolidine-2-carboxamide 2 by optimization of the P3 group afforded novel, low molecular weight thrombin inhibitors. Heterocycle replacement of the hydroxyl functional group helped maintain thrombin in vitro potency while improving the chemical stability and pharmacokinetic profile. These modifications led to the identification of compound 10, which showed excellent selectivity over related serine proteases as well as in vivo efficacy in the rat arteriovenous shunt...
May 14, 2015: ACS Medicinal Chemistry Letters
Alan Dardik, Kenneth Ouriel, JinSong Wang, Christos Liapis
The 2014 meeting of the International Society for Vascular Surgery (ISVS) was held in Guangzhou, China, in conjunction with the fifth annual Wang Zhong-Gao's Vascular Forum, the eighth annual China Southern Endovascular Congress, and the third annual Straits Vascular Forum. Keynote addresses were given by Professors Christos Liapis, Wang Zhong-Gao, and Wang Shen-Ming. President Liapis presented the first ISVS Lifetime Achievement Award to Professor Wang Zhong-Gao for his multi-decade accomplishments establishing Vascular Surgery as a specialty in China...
October 2014: Vascular
Tao Wang, Michelle L Lamb, Michael H Block, Audrey Molina Davies, Yongxin Han, Ethan Hoffmann, Stephanos Ioannidis, John A Josey, Zhong-Ying Liu, Paul D Lyne, Terry MacIntyre, Peter J Mohr, Charles A Omer, Tove Sjögren, Kenneth Thress, Bin Wang, Haiyun Wang, Dingwei Yu, Hai-Jun Zhang
Trk receptor tyrosine kinases have been implicated in cancer and pain. A crystal structure of TrkA with AZ-23 (1a) was obtained, and scaffold hopping resulted in two 5/6-bicyclic series comprising either imidazo[4,5-b]pyridines or purines. Further optimization of these two fusion series led to compounds with subnanomolar potencies against TrkA kinase in cellular assays. Antitumor effects in a TrkA-driven mouse allograft model were demonstrated with compounds 2d and 3a.
September 13, 2012: ACS Medicinal Chemistry Letters
Kenneth Rolston, Weiqun Wang, Lior Nesher, Elizabeth Coyle, Samuel Shelburne, Randall A Prince
Telavancin is a dual action, bactericidal lipoglycopeptide. Its in vitro activity was compared with vancomycin and linezolid against 392 Gram-positive isolates from cancer patients. MIC90 values (μg ml(-1)) for telavancin, vancomycin and linezolid were determined for methicillin-susceptible Staphylococcus aureus (MSSA), methicillin-resistant S. aureus (MRSA), methicillin-susceptible (MS), methicillin-resistant (MR), coagulase-negative staphylococci (CoNS), viridans group streptococci (VGS), Streptococcus pneumoniae, Bacillus species, Corynebacterium species and Micrococcus species...
July 2014: Journal of Antibiotics
Stephanie E Bettis, Kenneth Hanson, Li Wang, Melissa K Gish, Javier J Concepcion, Zhen Fang, Thomas J Meyer, John M Papanikolas
Femtosecond transient absorption spectroscopy is used to characterize the first photoactivation step in a chromophore/water oxidation catalyst assembly formed through a "layer-by-layer" approach. Assemblies incorporating both chromophores and catalysts are central to the function of dye-sensitized photoelectrosynthesis cells (DSPECs) for generating solar fuels. The chromophore, [Rua(II)](2+) = [Ru(pbpy)2(bpy)](2+), and water oxidation catalyst, [Rub(II)-OH2](2+) = [Ru(4,4'-(CH2PO3H2)2bpy)(Mebimpy)(H2O)](2+), where bpy = 2,2'-bipyridine, pbpy = 4,4'-(PO3H2)2bpy, and Mebimpy = 2,6-bis(1-methylbenzimidazol-2-yl)pyridine), are arranged on nanocrystalline TiO2 via phosphonate-Zr(IV) coordination linkages...
November 13, 2014: Journal of Physical Chemistry. A
Ozgur Sahin, Qingfei Wang, Samuel W Brady, Kenneth Ellis, Hai Wang, Chia-Chi Chang, Qingling Zhang, Preety Priya, Rui Zhu, Stephen T Wong, Melissa D Landis, William J Muller, Francisco J Esteva, Jenny Chang, Dihua Yu
Combinatorial targeted therapies are more effective in treating cancer by blocking by-pass mechanisms or inducing synthetic lethality. However, their clinical application is hampered by resistance and toxicity. To meet this important challenge, we developed and tested a novel concept of biomarker-guided sequential applications of various targeted therapies using ErbB2-overexpressing/PTEN-low, highly aggressive breast cancer as our model. Strikingly, sustained activation of ErbB2 and downstream pathways drives trastuzumab resistance in both PTEN-low/trastuzumab-resistant breast cancers from patients and mammary tumors with intratumoral heterogeneity from genetically-engineered mice...
May 2014: Cell Research
Fengxia Xiao, Yeong C Kim, Hongxiu Wen, Jiangtao Luo, Peixian Chen, Kenneth Cowan, San Ming Wang
Genetic studies often use genomic DNA from whole blood cells, of which the majority are the polymorphonuclear myeloid cells. Those cells undergo dramatic change of nuclear morphology following cellular differentiation. It remains elusive if the nuclear morphological change accompanies sequence alternations from the intact genome. If such event exists, it will cause a serious problem in using such type of genomic DNA for genetic study as the sequences will not represent the intact genome in the host individuals...
2013: PloS One
Miguel Martin, Jacques Bonneterre, Charles E Geyer, Yoshinori Ito, Jungsil Ro, Istvan Lang, Sung-Bae Kim, Caroline Germa, Jennifer Vermette, Kenneth Wang, Kongming Wang, Ahmad Awada
BACKGROUND: The safety and efficacy of neratinib monotherapy were compared with that of lapatinib plus capecitabine in patients with human epidermal growth factor receptor-2-positive (HER2+), locally advanced/metastatic breast cancer and prior trastuzumab treatment. METHODS: Patients received neratinib 240mg/d continuously (n=117) or lapatinib 1250mg/d continuously plus capecitabine 2000mg/m(2) per day on days 1-14 of each 21-d cycle (n=116). The primary aim was to demonstrate non-inferiority of neratinib for progression-free survival (PFS)...
December 2013: European Journal of Cancer
Jennifer L Collinger, Michael L Boninger, Tim M Bruns, Kenneth Curley, Wei Wang, Douglas J Weber
Spinal cord injury (SCI) often affects a person's ability to perform critical activities of daily living and can negatively affect his or her quality of life. Assistive technology aims to bridge this gap in order to augment function and increase independence. It is critical to involve consumers in the design and evaluation process as new technologies such as brain-computer interfaces (BCIs) are developed. In a survey study of 57 veterans with SCI participating in the 2010 National Veterans Wheelchair Games, we found that restoration of bladder and bowel control, walking, and arm and hand function (tetraplegia only) were all high priorities for improving quality of life...
2013: Journal of Rehabilitation Research and Development
Reena Shakya, Tamas Gonda, Michael Quante, Martha Salas, Samuel Kim, Jenna Brooks, Steffen Hirsch, Justine Davies, Angelica Cullo, Kenneth Olive, Timothy C Wang, Matthias Szabolcs, Benjamin Tycko, Thomas Ludwig
Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy that resists current treatments. To test epigenetic therapy against this cancer, we used the DNA demethylating drug 5-aza-2'-deoxycytidine (DAC) in an aggressive mouse model of stromal rich PDAC (KPC-Brca1 mice). In untreated tumors, we found globally decreased 5-methyl-cytosine (5-mC) in malignant epithelial cells and in cancer-associated myofibroblasts (CAF), along with increased amounts of 5-hydroxymethyl-cytosine (5-HmC) in CAFs, in progression from pancreatic intraepithelial neoplasia to PDAC...
January 15, 2013: Cancer Research
Kenneth Hung, Jui-Chih Wang, Cheng-Wei Chen, Cheng-Long Chuang, Kun-Nan Tsai, Chung-Ming Chen
Most alignment algorithms find an initial equivalent residue pair followed by an iterative optimization process to explore better near-optimal alignments in the surrounding solution space of the initial alignment. It plays a decisive role in determining the alignment quality since a poor initial alignment may make the final alignment trapped in an undesirable local optimum even with an iterative optimization. We proposed a vector-based alignment algorithm with a new initial alignment approach accounting for local structure features called MIRAGE-align...
November 2012: IEEE Transactions on Information Technology in Biomedicine
Corinna Dan, Kenneth Tai, Su Wang, Jeffrey Caballero, Melinda Martin, Stacy Lavilla, Nina Agbayani
No abstract text is available yet for this article.
May 2012: Journal of Health Care for the Poor and Underserved
Chaur-Jian Hsu, Michael R Kane, Kenneth Winkler, Canyun Wang, David Linton Johnson
In the laboratory setup, a borehole traverses a dry sandstone formation, which is subjected to a controlled uniaxial stress in the direction perpendicular to the borehole axis. Measurements are made in a single loading-unloading stress cycle from zero to 10 MPa and then back down to zero stress. The applied stress and the presence of the borehole induce anisotropy in the bulk of the material and stress concentration around the borehole, both azimuthally and radially. Acoustic waves are generated and detected in the water-filled borehole, including compressional and shear headwaves, as well as modes of monopole, dipole, quadrupole, and higher order azimuthal symmetries...
October 2011: Journal of the Acoustical Society of America
Kenneth Kollias, Hengyu Wang, Ying Song, Min Zou
The wettability of glass substrates textured via aluminum-induced crystallization (AIC) of amorphous silicon (a-Si) was studied. It was found that a stable superhydrophilic surface could be produced by AIC of a-Si. This research suggests that densely distributed micron-sized silicon islands with nanoscale silicon spikes produced by the technique of AIC of a-Si are responsible for the stable superhydrophilicity. The study also shows that these superhydrophilic surfaces can be easily converted to superhydrophobic ones by means of coating with C(4)F(8)...
November 19, 2008: Nanotechnology
Kenneth Plante, Eryu Wang, Charalambos D Partidos, James Weger, Rodion Gorchakov, Konstantin Tsetsarkin, Erin M Borland, Ann M Powers, Robert Seymour, Dan T Stinchcomb, Jorge E Osorio, Ilya Frolov, Scott C Weaver
Chikungunya virus (CHIKV) is a reemerging mosquito-borne pathogen that has recently caused devastating urban epidemics of severe and sometimes chronic arthralgia. As with most other mosquito-borne viral diseases, control relies on reducing mosquito populations and their contact with people, which has been ineffective in most locations. Therefore, vaccines remain the best strategy to prevent most vector-borne diseases. Ideally, vaccines for diseases of resource-limited countries should combine low cost and single dose efficacy, yet induce rapid and long-lived immunity with negligible risk of serious adverse reactions...
July 2011: PLoS Pathogens
Salim S Virani, Lechauncy D Woodard, Cassie R Landrum, Kenneth Pietz, Degang Wang, Christie M Ballantyne, Laura A Petersen
BACKGROUND: The aim of this analysis was to identify the proportion of coronary heart disease (CHD) patients achieving guideline-recommended low-density lipoprotein cholesterol (LDL-C) and non-high-density lipoprotein cholesterol (non-HDL-C) goals and to identify correlates of dual goal attainment. METHODS: We analyzed patient, provider, and facility characteristics for 21,801 CHD patients in one Veterans Affairs Hospitals Network. RESULTS: Low-density lipoprotein cholesterol goal attainment was 80%, but optional LDL-C goal attainment was 41%...
June 2011: American Heart Journal
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