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Kenneth Wang

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https://www.readbyqxmd.com/read/28303028/alectinib-ch5424802-antagonizes-abcb1-and-abcg2-mediated-multidrug-resistance-in-vitro-in-vivo-and-ex-vivo
#1
Ke Yang, Yifan Chen, Kenneth Kin Wah To, Fang Wang, Delan Li, Likun Chen, Liwu Fu
Alectinib, an inhibitor of anaplastic lymphoma kinase (ALK), was approved by the Food and Drug Administration (FDA) for the treatment of patients with ALK-positive non-small cell lung cancer (NSCLC). Here we investigated the reversal effect of alectinib on multidrug resistance (MDR) induced by ATP-binding cassette (ABC) transporters, which is the primary cause of chemotherapy failure. We provide the first evidence that alectinib increases the sensitivity of ABCB1- and ABCG2-overexpressing cells to chemotherapeutic agents in vitro and in vivo...
March 17, 2017: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/28300169/double-flow-focused-liquid-injector-for-efficient-serial-femtosecond-crystallography
#2
Dominik Oberthuer, Juraj Knoška, Max O Wiedorn, Kenneth R Beyerlein, David A Bushnell, Elena G Kovaleva, Michael Heymann, Lars Gumprecht, Richard A Kirian, Anton Barty, Valerio Mariani, Aleksandra Tolstikova, Luigi Adriano, Salah Awel, Miriam Barthelmess, Katerina Dörner, P Lourdu Xavier, Oleksandr Yefanov, Daniel R James, Garrett Nelson, Dingjie Wang, George Calvey, Yujie Chen, Andrea Schmidt, Michael Szczepek, Stefan Frielingsdorf, Oliver Lenz, Edward Snell, Philip J Robinson, Božidar Šarler, Grega Belšak, Marjan Maček, Fabian Wilde, Andrew Aquila, Sébastien Boutet, Mengning Liang, Mark S Hunter, Patrick Scheerer, John D Lipscomb, Uwe Weierstall, Roger D Kornberg, John C H Spence, Lois Pollack, Henry N Chapman, Saša Bajt
Serial femtosecond crystallography requires reliable and efficient delivery of fresh crystals across the beam of an X-ray free-electron laser over the course of an experiment. We introduce a double-flow focusing nozzle to meet this challenge, with significantly reduced sample consumption, while improving jet stability over previous generations of nozzles. We demonstrate its use to determine the first room-temperature structure of RNA polymerase II at high resolution, revealing new structural details. Moreover, the double flow-focusing nozzles were successfully tested with three other protein samples and the first room temperature structure of an extradiol ring-cleaving dioxygenase was solved by utilizing the improved operation and characteristics of these devices...
March 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28299310/corrigendum-fluidic-logic-used-in-a-systems-approach-to-enable-integrated-single-cell-functional-analysis
#3
Naveen Ramalingam, Brian Fowler, Lukasz Szpankowski, Anne A Leyrat, Kyle Hukari, Myo Thu Maung, Wiganda Yorza, Michael Norris, Chris Cesar, Joe Shuga, Michael L Gonzales, Chad D Sanada, Xiaohui Wang, Rudy Yeung, Win Hwang, Justin Axsom, Naga Sai Gopi Krishna Devaraju, Ninez Delos Angeles, Cassandra Greene, Ming-Fang Zhou, Eng-Seng Ong, Chang-Chee Poh, Marcos Lam, Henry Choi, Zaw Htoo, Leo Lee, Chee-Sing Chin, Zhong-Wei Shen, Chong T Lu, Ilona Holcomb, Aik Ooi, Craig Stolarczyk, Tony Shuga, Kenneth J Livak, Cate Larsen, Marc Unger, Jay A A West
[This corrects the article on p. 70 in vol. 4, PMID: 27709111.].
2017: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/28283652/brca2-hypomorphic-missense-variants-confer-moderate-risks-of-breast-cancer
#4
Hermela Shimelis, Romy L S Mesman, Catharina Von Nicolai, Asa Ehlen, Lucia Guidugli, Charlotte Martin, Fabienne Mgr Calleja, Huong Meeks, Emily Hallberg, Jamie Hinton, Jenna Lilyquist, Chunling Hu, Cora M Aalfs, Kristiina Aittomaki, Irene L Andrulis, Hoda Anton-Culver, Volker Arndt, Matthias W Beckmann, Javier J Benitez, Natalia Bogdanova, Stig E Bojesen, Manjeet K Bolla, Anne-Lise Borresen-Dale, Hiltrud Brauch, Paul Brennan, Hermann Brenner, Annegien Broeks, Barbara Brouwers, Thomas Bruning, Barbara Burwinkel, Jenny Chang-Claude, Georgia Chenevix-Trench, Ching-Yu Cheng, Ji-Yeob Choi, J Margriet Collée, Angela Cox, Simon S Cross, Kamila Czene, Hatef Darabi, Joe Dennis, Thilo Dork, Isabel Dos Santos Silva, Alison M Dunning, Peter A Fasching, Jonine D Figueroa, Henrik Flyger, Montserrat Garcia-Closas, Graham G Giles, Gord Glendon, Pascal Guenel, Christopher A Haiman, Per Hall, Ute Hamann, Mikael Hartman, Frans B L Hogervorst, Antoinette Hollestelle, John L Hopper, Hidemi Ito, Anna Jakubowska, Daehee Kang, Veli-Matti Kosma, Vessela Kristensen, Kah-Nyin Lai, Diether Lambrechts, Loic Le Marchand, Jingmei Li, Annika Lindblom, Artitaya Lophatananon, Jan Lubinski, Eva Machackova, Arto Mannermaa, Sara Margolin, Frederik Marme, Keitaro Matsuo, Hui Miao, Kyriaki Michailidou, Roger L Milne, Kenneth Muir, Susan L Neuhausen, Heli Nevanlinna, Janet E Olson, Curtis Olswold, Jan C Oosterwijk, Ana Osorio, Paolo Peterlongo, Julian Peto, Paul D P Pharoah, Katri Pylkäs, Paolo Radice, Muhammad U Rashid, Valerie Rhenius, Anja Rudolph, Suleeporn Sangrajrang, Elinor J Sawyer, Marjanka K Schmidt, Minouk J Schoemaker, Caroline M Seynaeve, Mitul Shah, Chen-Yang Shen, Martha J Shrubsole, Xiao-Ou Shu, Susan L Slager, Melissa C Southey, Daniel O Stram, Anthony J Swerdlow, Soo Hwang Teo, Ian Tomlinson, Diana Torres, Therese Truong, Christi J van Asperen, Lizet E van der Kolk, Qin Wang, Robert Winqvist, Anna H Wu, Jyh-Cherng Yu, Wei Zheng, Ying Zheng, Jennifer Leary, Logan C Walker, Lenka Foretova, Florentia Fostira, Kathleen Claes, Liliana Varesco, Setareh Moghadasi, Douglas F Easton, Amanda B Spurdle, Peter Devilee, Harry Vrieling, Alvaro N Monteiro, David E Goldgar, Aura Carreira, Maaike P G Vreeswijk, Fergus J Couch
Breast cancer risks conferred by many germline missense variants in the BRCA1 and BRCA2 genes, often referred to as variants of uncertain significance (VUS), have not been established. In this study, associations between 19 BRCA1 and 33 BRCA2 missense substitution variants and breast cancer risk were investigated through a breast cancer case control study using genotyping data from 38 studies of predominantly European ancestry (41,890 cases and 41,607 controls) and nine studies of Asian ancestry (6,269 cases and 6,624 controls)...
March 10, 2017: Cancer Research
https://www.readbyqxmd.com/read/28279611/co-liquefaction-of-spent-coffee-grounds-and-lignocellulosic-feedstocks
#5
Linxi Yang, Quan Sophia He, Peter Havard, Kenneth Corscadden, Chunbao Charles Xu, Xuan Wang
Co-liquefaction of spent coffee grounds (SCG) with paper filter (PF), corn stalk (CS) and white pine bark (WPB) respectively, was examined in subcritical water for bio-crude oil production. The optimum reaction temperature was 250°C, and the mixing biomass ratio was 1:1. SCG and CS was identified to be the best feedstock combination with a significant positive synergetic effect in the co-liquefaction process with 5% NaOH as a catalyst. The yield of bio-crude oil was increased by 20.9% compared to the mass averaged yield from two feedstocks, and the oil quality was also improved in terms of viscosity and relative molecular mass...
February 21, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28279462/screening-and-preventive-strategies-in-esophagogastric-cancer
#6
REVIEW
Liam Zakko, Lori Lutzke, Kenneth K Wang
Gastric adenocarcinoma, esophageal adenocarcinoma, and esophageal squamous cell carcinoma are among the most prevalent and deadly of malignancies worldwide. Screening and prevention programs will be critical to finally improving outcomes in these diseases. For gastric adenocarcinoma, screening in high-risk populations has significantly reduced mortality. More research is needed on screening high-risk individuals in low-risk populations. For esophageal adenocarcinoma, work is needed to develop efficient and effective techniques in mass screening programs...
April 2017: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/28274958/cabozantinib-eradicates-advanced-murine-prostate-cancer-by-activating-anti-tumor-innate-immunity
#7
Akash Patnaik, Kenneth D Swanson, Eva Csizmadia, Aniruddh Solanki, Natalie Landon-Brace, Marina P Gehring, Katja Helenius, Brian M Olson, Athalia R Pyzer, Lily C Wang, Olivier Elemento, Jesse Novak, Thomas B Thornley, John M Asara, Laleh Montaser, Joshua J Timmons, Todd M Morgan, Yugang Wang, Elena Levantini, John G Clohessy, Kathleen Kelly, Pier Paolo Pandolfi, Jacalyn M Rosenblatt, David E Avigan, Huihui Ye, Jeffrey M Karp, Sabina Signoretti, Steven P Balk, Lewis C Cantley
Several kinase inhibitors that target aberrant signaling pathways in tumor cells have been deployed in cancer therapy. However, their impact on the tumor immune microenvironment remains poorly understood. The tyrosine kinase inhibitor cabozantinib showed striking responses in cancer clinical trial patients across several malignancies. Here we show that cabozantinib rapidly eradicates invasive, poorly-differentiated PTEN/p53 deficient murine prostate cancer. This was associated with enhanced release of neutrophil chemotactic factors from tumor cells, including CXCL12 and HMGB1, resulting in robust infiltration of neutrophils into the tumor...
March 8, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28244745/the-ecstasy-and-agony-of-assay-interference-compounds
#8
Courtney Aldrich, Carolyn Bertozzi, Gunda I Georg, Laura Kiessling, Craig Lindsley, Dennis Liotta, Kenneth M Merz, Alanna Schepartz, Shaomeng Wang
No abstract text is available yet for this article.
February 28, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28244743/the-ecstasy-and-agony-of-assay-interference-compounds
#9
Courtney Aldrich, Carolyn Bertozzi, Gunda I Georg, Laura Kiessling, Craig Lindsley, Dennis Liotta, Kenneth M Merz, Alanna Schepartz, Shaomeng Wang
No abstract text is available yet for this article.
February 28, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28244742/the-ecstasy-and-agony-of-assay-interference-compounds
#10
Courtney Aldrich, Carolyn Bertozzi, Gunda I Georg, Laura Kiessling, Craig Lindsley, Dennis Liotta, Kenneth M Merz, Alanna Schepartz, Shaomeng Wang
No abstract text is available yet for this article.
March 14, 2017: Biochemistry
https://www.readbyqxmd.com/read/28244737/the-ecstasy-and-agony-of-assay-interference-compounds
#11
Courtney Aldrich, Carolyn Bertozzi, Gunda I Georg, Laura Kiessling, Craig Lindsley, Dennis Liotta, Kenneth M Merz, Alanna Schepartz, Shaomeng Wang
No abstract text is available yet for this article.
February 28, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28244728/the-ecstasy-and-agony-of-assay-interference-compounds
#12
Courtney Aldrich, Carolyn Bertozzi, Gunda I Georg, Laura Kiessling, Craig Lindsley, Dennis Liotta, Kenneth M Merz, Alanna Schepartz, Shaomeng Wang
No abstract text is available yet for this article.
February 28, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28244723/the-ecstasy-and-agony-of-assay-interference-compounds
#13
Courtney Aldrich, Carolyn Bertozzi, Gunda I Georg, Laura Kiessling, Craig Lindsley, Dennis Liotta, Kenneth M Merz, Alanna Schepartz, Shaomeng Wang
No abstract text is available yet for this article.
February 28, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/28241208/association-between-telomere-length-and-risk-of-cancer-and-non-neoplastic-diseases-a-mendelian-randomization-study
#14
Philip C Haycock, Stephen Burgess, Aayah Nounu, Jie Zheng, George N Okoli, Jack Bowden, Kaitlin Hazel Wade, Nicholas J Timpson, David M Evans, Peter Willeit, Abraham Aviv, Tom R Gaunt, Gibran Hemani, Massimo Mangino, Hayley Patricia Ellis, Kathreena M Kurian, Karen A Pooley, Rosalind A Eeles, Jeffrey E Lee, Shenying Fang, Wei V Chen, Matthew H Law, Lisa M Bowdler, Mark M Iles, Qiong Yang, Bradford B Worrall, Hugh Stephen Markus, Rayjean J Hung, Chris I Amos, Amanda B Spurdle, Deborah J Thompson, Tracy A O'Mara, Brian Wolpin, Laufey Amundadottir, Rachael Stolzenberg-Solomon, Antonia Trichopoulou, N Charlotte Onland-Moret, Eiliv Lund, Eric J Duell, Federico Canzian, Gianluca Severi, Kim Overvad, Marc J Gunter, Rosario Tumino, Ulrika Svenson, Andre van Rij, Annette F Baas, Matthew J Bown, Nilesh J Samani, Femke N G van t'Hof, Gerard Tromp, Gregory T Jones, Helena Kuivaniemi, James R Elmore, Mattias Johansson, James Mckay, Ghislaine Scelo, Robert Carreras-Torres, Valerie Gaborieau, Paul Brennan, Paige M Bracci, Rachel E Neale, Sara H Olson, Steven Gallinger, Donghui Li, Gloria M Petersen, Harvey A Risch, Alison P Klein, Jiali Han, Christian C Abnet, Neal D Freedman, Philip R Taylor, John M Maris, Katja K Aben, Lambertus A Kiemeney, Sita H Vermeulen, John K Wiencke, Kyle M Walsh, Margaret Wrensch, Terri Rice, Clare Turnbull, Kevin Litchfield, Lavinia Paternoster, Marie Standl, Gonçalo R Abecasis, John Paul SanGiovanni, Yong Li, Vladan Mijatovic, Yadav Sapkota, Siew-Kee Low, Krina T Zondervan, Grant W Montgomery, Dale R Nyholt, David A van Heel, Karen Hunt, Dan E Arking, Foram N Ashar, Nona Sotoodehnia, Daniel Woo, Jonathan Rosand, Mary E Comeau, W Mark Brown, Edwin K Silverman, John E Hokanson, Michael H Cho, Jennie Hui, Manuel A Ferreira, Philip J Thompson, Alanna C Morrison, Janine F Felix, Nicholas L Smith, Angela M Christiano, Lynn Petukhova, Regina C Betz, Xing Fan, Xuejun Zhang, Caihong Zhu, Carl D Langefeld, Susan D Thompson, Feijie Wang, Xu Lin, David A Schwartz, Tasha Fingerlin, Jerome I Rotter, Mary Frances Cotch, Richard A Jensen, Matthias Munz, Henrik Dommisch, Arne S Schaefer, Fang Han, Hanna M Ollila, Ryan P Hillary, Omar Albagha, Stuart H Ralston, Chenjie Zeng, Wei Zheng, Xiao-Ou Shu, Andre Reis, Steffen Uebe, Ulrike Hüffmeier, Yoshiya Kawamura, Takeshi Otowa, Tsukasa Sasaki, Martin Lloyd Hibberd, Sonia Davila, Gang Xie, Katherine Siminovitch, Jin-Xin Bei, Yi-Xin Zeng, Asta Försti, Bowang Chen, Stefano Landi, Andre Franke, Annegret Fischer, David Ellinghaus, Carlos Flores, Imre Noth, Shwu-Fan Ma, Jia Nee Foo, Jianjun Liu, Jong-Won Kim, David G Cox, Olivier Delattre, Olivier Mirabeau, Christine F Skibola, Clara S Tang, Merce Garcia-Barcelo, Kai-Ping Chang, Wen-Hui Su, Yu-Sun Chang, Nicholas G Martin, Scott Gordon, Tracey D Wade, Chaeyoung Lee, Michiaki Kubo, Pei-Chieng Cha, Yusuke Nakamura, Daniel Levy, Masayuki Kimura, Shih-Jen Hwang, Steven Hunt, Tim Spector, Nicole Soranzo, Ani W Manichaikul, R Graham Barr, Bratati Kahali, Elizabeth Speliotes, Laura M Yerges-Armstrong, Ching-Yu Cheng, Jost B Jonas, Tien Yin Wong, Isabella Fogh, Kuang Lin, John F Powell, Kenneth Rice, Caroline L Relton, Richard M Martin, George Davey Smith
Importance: The causal direction and magnitude of the association between telomere length and incidence of cancer and non-neoplastic diseases is uncertain owing to the susceptibility of observational studies to confounding and reverse causation. Objective: To conduct a Mendelian randomization study, using germline genetic variants as instrumental variables, to appraise the causal relevance of telomere length for risk of cancer and non-neoplastic diseases. Data Sources: Genomewide association studies (GWAS) published up to January 15, 2015...
February 23, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28238955/persistence-of-non-dysplastic-barrett-s-esophagus-is-not-protective-against-progression-to-adenocarcinoma
#15
Rajesh Krishnamoorthi, Guilherme Piovezani Ramos, Nicholas Crews, Michele Johnson, Ross Dierkhising, Qian Shi, Brenda Ginos, Kenneth Wang, David Katzka, Navtej Buttar, Prasad G Iyer
No abstract text is available yet for this article.
February 23, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28228579/network-wide-oscillations-in-the-parkinsonian-state-alterations-in-neuronal-activities-occur-in-the-premotor-cortex-in-parkinsonian-non-human-primates
#16
Jing Wang, Luke A Johnson, Alicia L Jensen, Kenneth B Baker, Jerrold L Vitek
A number of studies suggest that Parkinson's disease (PD) is associated with alterations of neuronal activity patterns in the basal-ganglia-thalamocortical circuit. There are limited electrophysiological data, however, describing how premotor cortex, which is involved in movement and decision making, is likely impacted in PD. In this study, spontaneous local field potential (LFP) and single unit neuronal activity were recorded in the dorsal premotor area of non-human primates in both the naïve and parkinsonian state using the MPTP model of parkinsonism...
February 22, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28221009/synthesis-and-exploration-of-ladder-structured-large-aromatic-dianhydrides-as-organic-cathodes-for-rechargeable-lithium-batteries
#17
Qichun Zhang, Jian Xie, Wangqiao Chen, Zilong Wang, Choo Wei Jie Kenneth Choo Wei Jie, Ming Liu
Comparing to anode materials in Li-ion batteries, the research on cathode materials is far behind and their capacities are much smaller. Thus, in order to address these issues, we believe that organic conjugated materials could be a solution. In this study, we demonstrate two non-polymeric dianhydrides with large aromatic structures: NDA-4N (naphthalenetetracarboxylicdianhydride with four nitrogen atoms) and PDA-4N (perylenetetracarboxylicdianhydride with four nitrogen atoms). Their electrochemical properties have been investigated between 2...
February 21, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28202732/atomic-structure-of-granulin-determined-from-native-nanocrystalline-granulovirus-using-an-x-ray-free-electron-laser
#18
Cornelius Gati, Dominik Oberthuer, Oleksandr Yefanov, Richard D Bunker, Francesco Stellato, Elaine Chiu, Shin-Mei Yeh, Andrew Aquila, Shibom Basu, Richard Bean, Kenneth R Beyerlein, Sabine Botha, Sébastien Boutet, Daniel P DePonte, R Bruce Doak, Raimund Fromme, Lorenzo Galli, Ingo Grotjohann, Daniel R James, Christopher Kupitz, Lukas Lomb, Marc Messerschmidt, Karol Nass, Kimberly Rendek, Robert L Shoeman, Dingjie Wang, Uwe Weierstall, Thomas A White, Garth J Williams, Nadia A Zatsepin, Petra Fromme, John C H Spence, Kenneth N Goldie, Johannes A Jehle, Peter Metcalf, Anton Barty, Henry N Chapman
To understand how molecules function in biological systems, new methods are required to obtain atomic resolution structures from biological material under physiological conditions. Intense femtosecond-duration pulses from X-ray free-electron lasers (XFELs) can outrun most damage processes, vastly increasing the tolerable dose before the specimen is destroyed. This in turn allows structure determination from crystals much smaller and more radiation sensitive than previously considered possible, allowing data collection from room temperature structures and avoiding structural changes due to cooling...
February 28, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28199092/application-of-a-quantitative-lc-ms-multiattribute-method-for-monitoring-site-specific-glycan-heterogeneity-on-a-monoclonal-antibody-containing-two-n-linked-glycosylation-sites
#19
Tian Wang, Lily Chu, Wenzhou Li, Ken Lawson, Izydor Apostol, Tamer Eris
A significant challenge of traditional glycan mapping techniques is that they do not provide site-specific glycosylation information. Therefore, for proteins containing multiple glycosylation sites, the individual glycan species present at a particular site cannot be differentiated from those species present at the other glycosylation sites on the molecule. Quantification of glycoform has previously been demonstrated using a multiattribute method (MAM), which can quantify multiple post-translational modifications including deamidation, oxidation, glycosylation variants, and fragmentation ( Rogers, R...
February 27, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28198858/extended-temporal-cloak-based-on-the-inverse-temporal-talbot-effect
#20
Bowen Li, Xie Wang, Jiqiang Kang, Yuan Wei, Toni Yung, Kenneth K Y Wong
A temporal cloak with a significantly extended cloaking window and spatial distribution is created using the inverse temporal Talbot effect. The continuously cloaking window and the total cloaking ratio are 196 ps and 74%, respectively, which are 5.4 and 1.6 times larger than the previous record. Moreover, the cloak is maintained over 5-km of dispersion-compensating fiber (DCF), which enables cloaking temporal events at multiple positions simultaneously. To demonstrate the cloaking performance, both message-encoded and pseudo-random temporal events are successfully concealed...
February 15, 2017: Optics Letters
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