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Kenneth Wang

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https://www.readbyqxmd.com/read/29027465/multi-stage-structural-transformations-in-zero-strain-lithium-titanate-unveiled-by-in-situ-x-ray-absorption-fingerprints
#1
Wei Zhang, Mehmet Topsakal, Christina Cama, Christopher J Pelliccione, Hu Zhao, Steven Ehrlich, Lijun Wu, Yimei Zhu, Anatoly I Frenkel, Kenneth J Takeuchi, Esther S Takeuchi, Amy C Marschilok, Deyu Lu, Feng Wang
Zero-strain electrodes, such as spinel lithium titanate (Li4/3Ti5/3O4), are appealing for battery applications due to their negligible volume change and extraordinary stability upon repeated charge/discharge cycles. On the other hand, this same property makes it challenging to probe their structural changes during the electrochemical reaction. Herein, we report in situ studies of lithiation-driven structural transformations in Li4/3Ti5/3O4 via a combination of X-ray absorption spectroscopy and ab initio calculations...
October 13, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29023486/the-sea-cucumber-genome-provides-insights-into-morphological-evolution-and-visceral-regeneration
#2
Xiaojun Zhang, Lina Sun, Jianbo Yuan, Yamin Sun, Yi Gao, Libin Zhang, Shihao Li, Hui Dai, Jean-François Hamel, Chengzhang Liu, Yang Yu, Shilin Liu, Wenchao Lin, Kaimin Guo, Songjun Jin, Peng Xu, Kenneth B Storey, Pin Huan, Tao Zhang, Yi Zhou, Jiquan Zhang, Chenggang Lin, Xiaoni Li, Lili Xing, Da Huo, Mingzhe Sun, Lei Wang, Annie Mercier, Fuhua Li, Hongsheng Yang, Jianhai Xiang
Apart from sharing common ancestry with chordates, sea cucumbers exhibit a unique morphology and exceptional regenerative capacity. Here we present the complete genome sequence of an economically important sea cucumber, A. japonicus, generated using Illumina and PacBio platforms, to achieve an assembly of approximately 805 Mb (contig N50 of 190 Kb and scaffold N50 of 486 Kb), with 30,350 protein-coding genes and high continuity. We used this resource to explore key genetic mechanisms behind the unique biological characters of sea cucumbers...
October 2017: PLoS Biology
https://www.readbyqxmd.com/read/29023112/design-of-leucine-rich-repeat-kinase-2-lrrk2-inhibitors-using-a-crystallographic-surrogate-derived-from-checkpoint-kinase-1-chk1
#3
Douglas S Williamson, Garrick P Smith, Pamela Acheson-Dossang, Simon T Bedford, Victoria Chell, I-Jen Chen, Justus C A Daechsel, Zoe Daniels, Laurent David, Pawel Dokurno, Morten Hentzer, Martin C Herzig, Roderick E Hubbard, Jonathan D Moore, James B Murray, Samantha Newland, Stuart C Ray, Terry Shaw, Allan E Surgenor, Lindsey Terry, Kenneth Thirstrup, Yikang Wang, Kenneth V Christensen
Mutations in leucine-rich repeat kinase 2 (LRRK2), such as G2019S, are associated with an increased risk of developing Parkinson's disease. Surrogates for the LRRK2 kinase domain based on checkpoint kinase 1 (CHK1) mutants were designed, expressed in insect cells infected with baculovirus, purified and crystallized. X-ray structures of the surrogates complexed with known LRRK2 inhibitors rationalized compound potency and selectivity. The CHK1 10-point mutant was preferred, following assessment of surrogate binding affinity with LRRK2 inhibitors...
October 12, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29018166/hybrid-atrial-fibrillation-ablation-current-status-and-a-look-ahead
#4
REVIEW
Ali Khoynezhad, Kenneth A Ellenbogen, Talal Al-Atassi, Paul J Wang, Vigneshwar Kasirajan, Xunzhang Wang, James R Edgerton
No abstract text is available yet for this article.
October 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28986324/the-ubiquitin-conjugating-enzyme-ube2w-regulates-solubility-of-the-huntington-s-disease-protein-huntingtin
#5
Bo Wang, Li Zeng, Sean A Merillat, Joseph Ochaba, Leslie M Thompson, Sami J Barmada, Kenneth M Scaglione, Henry L Paulson
Huntington's disease (HD) is caused by a CAG repeat expansion that encodes a polyglutamine (polyQ) expansion in the HD disease protein, huntingtin (HTT). PolyQ expansion promotes misfolding and aggregation of mutant HTT (mHTT) within neurons. The cellular pathways, including ubiquitin-dependent processes, by which mHTT is regulated remain incompletely understood. Ube2W is the only ubiquitin conjugating enzyme (E2) known to ubiquitinate substrates at their amino (N)-termini, likely favoring substrates with disordered N-termini...
October 3, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28981617/transcription-factors-sp8-and-sp9-coordinately-regulate-olfactory-bulb-interneuron-development
#6
Jiwen Li, Chunyang Wang, Zhuangzhi Zhang, Yan Wen, Lei An, Qifei Liang, Zhejun Xu, Song Wei, Weiwei Li, Teng Guo, Guoping Liu, Guangxu Tao, Yan You, Heng Du, Zhuoning Fu, Miao He, Bin Chen, Kenneth Campbell, Arturo Alvarez-Buylla, John L Rubenstein, Zhengang Yang
Neural stem cells in the postnatal telencephalic ventricular-subventricular zone (V-SVZ) generate new interneurons, which migrate tangentially through the rostral migratory stream (RMS) into the olfactory bulb (OB). The Sp8 and Sp9 transcription factors are expressed in neuroblasts, as well as in the immature and mature interneurons in the V-SVZ-RMS-OB system. Here we show that Sp8 and Sp9 coordinately regulate OB interneuron development: although Sp9 null mutants show no major OB interneuron defect, conditional deletion of both Sp8 and Sp9 resulted in a much more severe reduction of OB interneuron number than that observed in the Sp8 conditional mutant mice, due to defects in neuronal differentiation, tangential and radial migration, and increased cell death in the V-SVZ-RMS-OB system...
August 1, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28968981/structure-based-design-synthesis-and-activity-studies-of-small-hybrid-molecules-as-hdac-and-g9a-dual-inhibitors
#7
Lanlan Zang, Shukkoor M Kondengaden, Qing Zhang, Xiaobo Li, Dilep K Sigalapalli, Shameer M Kondengadan, Kenneth Huang, Keqin Kathy Li, Shanshan Li, Zhongying Xiao, Liuqing Wen, Hailiang Zhu, Bathini N Babu, Lijuan Wang, Fengyuan Che, Peng George Wang
Aberrant enzymatic activities or expression profiles of epigenetic regulations are therapeutic targets for cancers. Among these, histone 3 lysine 9 methylation (H3K9Me2) and global de-acetylation on histone proteins are associated with multiple cancer phenotypes including leukemia, prostatic carcinoma, hepatocellular carcinoma and pulmonary carcinoma. Here, we report the discovery of the first small molecule capable of acting as a dual inhibitor targeting both G9a and HDAC. Our structure based design, synthesis, and screening for the dual activity of the small molecules led to the discovery of compound 14 which displays promising inhibition of both G9a and HDAC in low micro-molar range in cell based assays...
September 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28968167/gefitinib-plus-chemotherapy-versus-chemotherapy-in-epidermal-growth-factor-receptor-mutation-positive-non-small-cell-lung-cancer-resistant-to-first-line-gefitinib-impress-overall-survival-and-biomarker-analyses
#8
Tony S K Mok, Sang-We Kim, Yi-Long Wu, Kazuhiko Nakagawa, Jin-Ji Yang, Myung-Ju Ahn, Jie Wang, James Chih-Hsin Yang, You Lu, Shinji Atagi, Santiago Ponce, Xiaojin Shi, Yuri Rukazenkov, Vincent Haddad, Kenneth S Thress, Jean-Charles Soria
Purpose The Iressa Mutation-Positive Multicentre Treatment Beyond ProgRESsion Study (IMPRESS) compared the continuation of gefitinib plus chemotherapy with placebo plus chemotherapy in patients with epidermal growth factor receptor ( EGFR) mutation-positive advanced non-small-cell lung cancer with progression (Response Evaluation Criteria in Solid Tumors 1.1) after first-line gefitinib. Primary results indicated no difference between treatments in terms of progression-free survival (PFS). The current analysis presents final, mature, overall survival (OS) data, together with exploratory analyses that examined whether specific biomarkers, including T790M mutation status, were able to differentiate a relative treatment effect...
October 2, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28960967/diblock-copolymer-hydrophobicity-facilitates-efficient-gene-silencing-and-cytocompatible-nanoparticle-mediated-sirna-delivery-to-musculoskeletal-cell-types
#9
Dominic W Malcolm, Margaret A T Freeberg, Yuchen Wang, Kenneth R Sims, Hani A Awad, Danielle S W Benoit
pH-responsive diblock copolymers provide tailorable nanoparticle (NP) architecture and chemistry critical for siRNA delivery. Here, diblock polymers varying in first (corona) and second (core) block molecular weight (Mn), corona/core ratio, and core hydrophobicity (%BMA) were synthesized to determine their effect on siRNA delivery in murine tenocytes (mTenocyte) and murine and human mesenchymal stem cells (mMSC and hMSCs, respectively). NP-mediated siRNA uptake, gene silencing, and cytocompatibility were quantified...
October 11, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28960889/esnail-a-transcriptome-based-molecular-resource-of-the-central-nervous-system-for-terrestrial-gastropods
#10
Min Zhao, Tianfang Wang, Michael J Stewart, Utpal Bose, Saowaros Suwansa-Ard, Kenneth B Storey, Scott F Cummins
To expand on emerging terrestrial gastropod molecular resources, we have undertaken transcriptome-based sequencing of the central nervous system (CNS) from six ecologically invasive terrestrial gastropods. Focusing on snail species Cochlicella acuta and Helix aspersa, and reticulated slugs Deroceras invadens, Deroceras reticulatum, Lehmannia nyctelia, and Milax gagates, we obtained a total of 367,869,636 high quality reads and compared them with existing CNS transcript resources for the invasive Mediterranean snail, Theba pisana...
September 28, 2017: Molecular Ecology Resources
https://www.readbyqxmd.com/read/28957327/up-for-a-challenge-u4c-stimulating-innovation-in-breast-cancer-genetic-epidemiology
#11
EDITORIAL
Leah E Mechanic, Sara Lindström, Kenneth M Daily, Solveig K Sieberts, Christopher I Amos, Huann-Sheng Chen, Nancy J Cox, Marina Dathe, Eric J Feuer, Michael J Guertin, Joshua Hoffman, Yunxian Liu, Jason H Moore, Chad L Myers, Marylyn D Ritchie, Joellen Schildkraut, Fredrick Schumacher, John S Witte, Wen Wang, Scott M Williams, Elizabeth M Gillanders
No abstract text is available yet for this article.
September 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28951456/myc-inhibition-depletes-cancer-stem-like-cells-in-triple-negative-breast-cancer
#12
Aimin Yang, Shenghui Qin, Bradley A Schulte, Stephen P Ethier, Kenneth D Tew, Gavin Y Wang
There is mounting evidence that cancer stem-like cells (CSCs) are selectively enriched in residual tumors after anticancer therapies which may account for tumor recurrence and metastasis by regenerating new tumors. Thus, there is a critical need to develop new therapeutic agents that can effectively eliminate drug-resistant CSCs and improve the efficacy of cancer therapy. Here we report that Triptolide (C1572), a small molecule natural product selectively depletes CSCs in a dose-dependent fashion in human triple-negative breast cancer (TNBC) cell lines...
September 26, 2017: Cancer Research
https://www.readbyqxmd.com/read/28950101/tension-creates-an-endoreplication-wavefront-that-leads-regeneration-of-epicardial-tissue
#13
Jingli Cao, Jinhu Wang, Christopher P Jackman, Amanda H Cox, Michael A Trembley, Joseph J Balowski, Ben D Cox, Alessandro De Simone, Amy L Dickson, Stefano Di Talia, Eric M Small, Daniel P Kiehart, Nenad Bursac, Kenneth D Poss
Mechanisms that control cell-cycle dynamics during tissue regeneration require elucidation. Here we find in zebrafish that regeneration of the epicardium, the mesothelial covering of the heart, is mediated by two phenotypically distinct epicardial cell subpopulations. These include a front of large, multinucleate leader cells, trailed by follower cells that divide to produce small, mononucleate daughters. By using live imaging of cell-cycle dynamics, we show that leader cells form by spatiotemporally regulated endoreplication, caused primarily by cytokinesis failure...
September 25, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28947741/cryo-em-structure-of-the-extended-type-vi-secretion-system-sheath-tube-complex
#14
Jing Wang, Maximilian Brackmann, Daniel Castaño-Díez, Mikhail Kudryashev, Kenneth N Goldie, Timm Maier, Henning Stahlberg, Marek Basler
The bacterial type VI secretion system (T6SS) uses contraction of a long sheath to quickly thrust a tube with associated effectors across membranes of eukaryotic and bacterial cells (1-5) . Only limited structural information is available about the inherently unstable precontraction state of the T6SS. Here, we obtain a 3.7 Å resolution structure of a non-contractile sheath-tube complex using cryo-electron microscopy and show that it resembles the extended T6SS inside Vibrio cholerae cells. We build a pseudo-atomic model of the complete sheath-tube assembly, which provides a mechanistic understanding of coupling sheath contraction with pushing and rotating the inner tube for efficient target membrane penetration...
September 25, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28942944/death-receptor-3-regulates-distinct-pathological-attributes-of-acute-versus-chronic-murine-allergic-lung-inflammation
#15
Ravinder Kaur Singh, William Victor Perks, Jason Peter Twohig, Emma J Kidd, Kenneth Broadley, Stuart N Farrow, Anwen Sian Williams, Philip Russel Taylor, Eddie Chung Yern Wang
The Death Receptor 3 (DR3)/Tumour Necrosis Factor-like cytokine 1A (TL1A) axis stimulates effector T cells and type 2 innate lymphocytes (ILC2) that trigger cytokine release and drive disease pathology in several inflammatory and autoimmune diseases, including murine models of acute allergic lung inflammation (ALI). The aim of this study was to elucidate the role of DR3 in chronic ALI compared to acute ALI, using mice genetically deficient in the DR3 gene (DR3(ko)). Results showed DR3 expression in the lungs of wild-type mice was up-regulated following induction of acute ALI and this increased expression was maintained in chronic disease...
September 15, 2017: Cellular Immunology
https://www.readbyqxmd.com/read/28937538/severe-neonatal-cholestasis-in-cerebrotendinous-xanthomatosis-genetics-immunostaining-mass-spectrometry
#16
Jing-Yu Gong, Kenneth D R Setchell, Jing Zhao, Wujuan Zhang, Brian Wolfe, Yi Lu, Karolin Lackner, A S Knisely, Neng-Li Wang, Chen-Zhi Hao, Mei-Hong Zhang, Jian-She Wang
OBJECTIVES: Cerebrotendinous xanthomatosis (CTX) is caused by defects in sterol 27-hydroxylase (CYP27A1, encoded by CYP27A1), a key enzyme in the bile acid synthesis pathway. CTX usually presents as neurologic disease in adults or older children. The very rare reports of CTX manifest as neonatal cholestasis assess the cholestasis as transient, with patient survival. Our experience differs. METHODS: Homozygous or compound heterozygous CYP27A1 mutations were detected in 8 neonatal cholestasis patients by whole exome sequencing, panel sequencing, or Sanger sequencing...
September 20, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28936536/multimolecular-assemblies-on-high-surface-area-metal-oxides-and-their-role-in-interfacial-energy-and-electron-transfer
#17
REVIEW
Jamie C Wang, Sean P Hill, Tristan Dilbeck, Omotola O Ogunsolu, Tanmay Banerjee, Kenneth Hanson
High surface area metal oxides offer a unique substrate for the assembly of multiple molecular components at an interface. The choice of molecules, metal oxide, and the nature of the assembly method can have a profound influence on the mechanism, rate, and efficiency of photoinduced energy and electron transfer events at the interface. Owing to their diversity and high level of control, these interfacial assemblies are of interest for numerous applications including solar energy conversion, photoelectrosynthesis, photo-writable memory, and more...
September 22, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28927839/a-novel-method-to-prevent-catheter-dysfunction-during-spray-cryotherapy
#18
Kavel Visrodia, Liam Zakko, Theresa Nolte, Kenneth K Wang
No abstract text is available yet for this article.
September 16, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28927838/use-of-volumetric-laser-endomicroscopy-to-characterize-a-duodenal-neuroendocrine-tumor
#19
Amrit K Kamboj, Prasuna Muppa, Liam Zakko, Kenneth K Wang, Cadman L Leggett
No abstract text is available yet for this article.
September 16, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28919490/alcohol-exposure-induces-chick-craniofacial-bone-defects-by-negatively-affecting-cranial-neural-crest-development
#20
Ping Zhang, Guang Wang, Zhuangling Lin, Yushi Wu, Jing Zhang, Meng Liu, Kenneth Ka Ho Lee, Manli Chuai, Xuesong Yang
Excess alcohol consumption during pregnancy could lead to fetal alcohol syndrome (FAS). However, the molecular mechanism leading to craniofacial abnormality, a feature of FAS, is still poorly understood. The cranial neural crest cells (NCCs) contribute to the formation of the craniofacial bones. Therefore, NCCs exposed to ethanol was investigated - using chick embryos and in vitro explant culture as experimental models. We demonstrated that exposure to 2% ethanol induced craniofacial defects, which includes parietal defect, in the developing chick fetus...
September 14, 2017: Toxicology Letters
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