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Kenneth Wang

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https://www.readbyqxmd.com/read/29227576/microscopic-investigation-of-topically-applied-nanoparticles-for-molecular-imaging-of-fresh-tissue-surfaces
#1
Soyoung Kang, Yu Winston Wang, Xiaochun Xu, Eric Navarro, Kenneth M Tichauer, Jonathan T C Liu
Previous studies have shown that functionalized nanoparticles (NPs) topically applied on fresh tissues are able to rapidly target cell-surface protein biomarkers of cancer. Furthermore, studies have shown that a paired-agent approach, in which an untargeted NP is co-administered with a panel of targeted NPs, controls for nonspecific behavior of the NPs, enabling quantitative imaging of biomarker expression. However, given the complexities in nonspecific accumulation, diffusion, and chemical binding of targeted NPs in tissues, studies are needed to better understand these processes at the microscopic scale...
December 11, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/29218423/early-intraocular-pressure-change-after-peripheral-iridotomy-with-ultralow-fluence-pattern-scanning-laser-and-nd-yag-laser-in-primary-angle-closure-suspect-kowloon-east%C3%A2-pattern-scanning-laser-study-report-no-3
#2
Jeffrey Chi Wang Chan, Bonnie Nga Kwan Choy, Orlando Chia Chieh Chan, Kenneth Kai Wang Li
PURPOSE: Our purpose was to assess the early intraocular pressure (IOP) changes of ultralow fluence laser iridotomy using pattern scanning laser followed by neodymium:yttrium-aluminum-gamet (Nd:YAG) laser. METHODS: This is a prospective interventional study. Thirty-three eyes of 33 adult Chinese primary angle-closure suspect subjects were recruited for prophylactic laser peripheral iridotomy. Sequential laser peripheral iridotomy was performed using pattern scanning laser followed by Nd:YAG laser...
December 7, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29218117/basis-and-statistical-design-of-the-passive-hiv-1-antibody-mediated-prevention-amp-test-of-concept-efficacy-trials
#3
Peter B Gilbert, Michal Juraska, Allan C deCamp, Shelly Karuna, Srilatha Edupuganti, Nyaradzo Mgodi, Deborah J Donnell, Carter Bentley, Nirupama Sista, Philip Andrew, Abby Isaacs, Yunda Huang, Lily Zhang, Edmund Capparelli, Nidhi Kochar, Jing Wang, Susan H Eshleman, Kenneth H Mayer, Craig A Magaret, John Hural, James G Kublin, Glenda Gray, David C Montefiori, Margarita M Gomez, David N Burns, Julie McElrath, Julie Ledgerwood, Barney S Graham, John R Mascola, Myron Cohen, Lawrence Corey
Background: Anti-HIV-1 broadly neutralizing antibodies (bnAbs) have been developed as potential agents for prevention of HIV-1 infection. The HIV Vaccine Trials Network and the HIV Prevention Trials Network are conducting the Antibody Mediated Prevention (AMP) trials to assess whether, and how, intravenous infusion of the anti-CD4 binding site bnAb, VRC01, prevents HIV-1 infection. These are the first test-of-concept studies to assess HIV-1 bnAb prevention efficacy in humans. Methods: The AMP trials are two parallel phase 2b HIV-1 prevention efficacy trials conducted in two cohorts: 2700 HIV-uninfected men and transgender persons who have sex with men in the United States, Peru, Brazil, and Switzerland; and 1500 HIV-uninfected sexually active women in seven countries in sub-Saharan Africa...
January 2017: Statistical Communications in Infectious Diseases
https://www.readbyqxmd.com/read/29214033/lupus-related-single-nucleotide-polymorphisms-and-risk-of-diffuse-large-b-cell-lymphoma
#4
Sasha Bernatsky, Héctor A Velásquez García, John J Spinelli, Patrick Gaffney, Karin E Smedby, Rosalind Ramsey-Goldman, Sophia S Wang, Hans-Olov Adami, Demetrius Albanes, Emanuele Angelucci, Stephen M Ansell, Yan W Asmann, Nikolaus Becker, Yolanda Benavente, Sonja I Berndt, Kimberly A Bertrand, Brenda M Birmann, Heiner Boeing, Paolo Boffetta, Paige M Bracci, Paul Brennan, Angela R Brooks-Wilson, James R Cerhan, Stephen J Chanock, Jacqueline Clavel, Lucia Conde, Karen H Cotenbader, David G Cox, Wendy Cozen, Simon Crouch, Anneclaire J De Roos, Silvia de Sanjose, Simonetta Di Lollo, W Ryan Diver, Ahmet Dogan, Lenka Foretova, Hervé Ghesquières, Graham G Giles, Bengt Glimelius, Thomas M Habermann, Corinne Haioun, Patricia Hartge, Henrik Hjalgrim, Theodore R Holford, Elizabeth A Holly, Rebecca D Jackson, Rudolph Kaaks, Eleanor Kane, Rachel S Kelly, Robert J Klein, Peter Kraft, Anne Kricker, Qing Lan, Charles Lawrence, Mark Liebow, Tracy Lightfoot, Brian K Link, Marc Maynadie, James McKay, Mads Melbye, Thierry J Molina, Alain Monnereau, Lindsay M Morton, Alexandra Nieters, Kari E North, Anne J Novak, Kenneth Offit, Mark P Purdue, Marco Rais, Jacques Riby, Eve Roman, Nathaniel Rothman, Gilles Salles, Gianluca Severi, Richard K Severson, Christine F Skibola, Susan L Slager, Alex Smith, Martyn T Smith, Melissa C Southey, Anthony Staines, Lauren R Teras, Carrie A Thompson, Hervé Tilly, Lesley F Tinker, Anne Tjonneland, Jenny Turner, Claire M Vajdic, Roel C H Vermeulen, Joseph Vijai, Paolo Vineis, Jarmo Virtamo, Zhaoming Wang, Stephanie Weinstein, Thomas E Witzig, Andrew Zelenetz, Anne Zeleniuch-Jacquotte, Yawei Zhang, Tongzhang Zheng, Mariagrazia Zucca, Ann E Clarke
Objective: Determinants of the increased risk of diffuse large B-cell lymphoma (DLBCL) in SLE are unclear. Using data from a recent lymphoma genome-wide association study (GWAS), we assessed whether certain lupus-related single nucleotide polymorphisms (SNPs) were also associated with DLBCL. Methods: GWAS data on European Caucasians from the International Lymphoma Epidemiology Consortium (InterLymph) provided a total of 3857 DLBCL cases and 7666 general-population controls...
2017: Lupus Science & Medicine
https://www.readbyqxmd.com/read/29212950/pi3k%C3%AE-inactivation-in-leptin-receptor-cells-increases-leptin-sensitivity-but-disrupts-growth-and-reproduction
#5
David Garcia-Galiano, Beatriz C Borges, Jose Donato, Susan J Allen, Nicole Bellefontaine, Mengjie Wang, Jean J Zhao, Kenneth M Kozloff, Jennifer W Hill, Carol F Elias
The role of PI3K in leptin physiology has been difficult to determine due to its actions downstream of several metabolic cues, including insulin. Here, we used a series of mouse models to dissociate the roles of specific PI3K catalytic subunits and of insulin receptor (InsR) downstream of leptin signaling. We show that disruption of p110α and p110β subunits in leptin receptor cells (LRΔα+β) produces a lean phenotype associated with increased energy expenditure, locomotor activity, and thermogenesis. LRΔα+β mice have deficient growth and delayed puberty...
December 7, 2017: JCI Insight
https://www.readbyqxmd.com/read/29204330/a-bias-in-the-evaluation-of-bias-comparing-randomized-trials-with-nonexperimental-studies
#6
Jessica M Franklin, Sara Dejene, Krista F Huybrechts, Shirley V Wang, Martin Kulldorff, Kenneth J Rothman
In a recent BMJ article, the authors conducted a meta-analysis to compare estimated treatment effects from randomized trials with those derived from observational studies based on routinely collected data (RCD). They calculated a pooled relative odds ratio (ROR) of 1.31 (95% confidence interval [CI]: 1.03-1.65) and concluded that RCD studies systematically over-estimated protective effects. However, their meta-analysis inverted results for some clinical questions to force all estimates from RCD to be below 1...
April 2017: Epidemiologic Methods
https://www.readbyqxmd.com/read/29203663/selected-reaction-monitoring-approach-for-validating-peptide-biomarkers
#7
Qing Wang, Ming Zhang, Tyler Tomita, Joshua T Vogelstein, Shibin Zhou, Nickolas Papadopoulos, Kenneth W Kinzler, Bert Vogelstein
We here describe a selected reaction monitoring (SRM)-based approach for the discovery and validation of peptide biomarkers for cancer. The first stage of this approach is the direct identification of candidate peptides through comparison of proteolytic peptides derived from the plasma of cancer patients or healthy individuals. Several hundred candidate peptides were identified through this method, providing challenges for choosing and validating the small number of peptides that might prove diagnostically useful...
December 4, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29203080/diastolic-wall-strain-is-associated-with-incident-heart-failure-in-african-americans-insights-from-the-atherosclerosis-risk-in-communities-study
#8
Daisuke Kamimura, Takeki Suzuki, Michael E Hall, Wanmei Wang, Michael D Winniford, Amil M Shah, Carlos J Rodriguez, Kenneth R Butler, Thomas H Mosley
BACKGROUND: Increased left ventricular (LV) myocardial stiffness may be associated with impaired LV hemodynamics and incident heart failure (HF). However, an indicator that estimates LV myocardial stiffness easily and non-invasively is lacking. The purpose of this study was to determine whether diastolic wall strain (DWS), an echocardiographic estimator of LV myocardial stiffness, is associated with incident HF in a middle-aged community-based cohort of African Americans. METHODS AND RESULTS: We investigated associations between DWS and incident HF among 1528 African Americans (mean age 58...
December 1, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/29202471/apoptosis-induced-cxcl5-accelerates-inflammation-and-growth-of-prostate-tumor-metastases-in-bone
#9
Hernan Roca, Jacqueline D Jones, Marta C Purica, Savannah Weidner, Amy J Koh, Robert Kuo, John E Wilkinson, Yugang Wang, Stephanie Daignault-Newton, Kenneth J Pienta, Todd M Morgan, Evan T Keller, Jacques E Nör, Lonnie D Shea, Laurie K McCauley
During tumor progression, immune system phagocytes continually clear apoptotic cancer cells in a process known as efferocytosis. However, the impact of efferocytosis in metastatic tumor growth is unknown. In this study, we observed that macrophage-driven efferocytosis of prostate cancer cells in vitro induced the expression of proinflammatory cytokines such as CXCL5 by activating Stat3 and NF-κB(p65) signaling. Administration of a dimerizer ligand (AP20187) triggered apoptosis in 2 in vivo syngeneic models of bone tumor growth in which apoptosis-inducible prostate cancer cells were either coimplanted with vertebral bodies, or inoculated in the tibiae of immunocompetent mice...
November 27, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29200354/hepatitis-c-testing-increased-among-baby-boomers-following-the-2012-change-to-cdc-testing-recommendations
#10
Joshua A Barocas, Jianing Wang, Laura F White, Abriana Tasillo, Joshua A Salomon, Kenneth A Freedberg, Benjamin P Linas
In 2012 the Centers for Disease Control and Prevention recommended routine testing for hepatitis C for people born in the period 1945-65. Until now, the recommendation's impact on hepatitis C screening rates in the United States has not been fully understood. We used an interrupted time series with comparison group design to analyze hepatitis C screening rates in the period 2010-14 among 2.8 million commercially insured adults in the MarketScan database. Hepatitis C screening rates increased yearly between 2010 and 2014, from 1...
December 2017: Health Affairs
https://www.readbyqxmd.com/read/29199147/factors-associated-with-progression-of-barrett-s-esophagus-a-systematic-review-and-meta-analysis
#11
Rajesh Krishnamoorthi, Siddharth Singh, Karthik Ragunathan, Kavel Visrodia, Kenneth K Wang, David A Katzka, Prasad G Iyer
BACKGROUND & AIMS: Endoscopic surveillance of patients with Barrett's esophagus (BE) is inefficient. Risk stratification of patients might improve the effectiveness of surveillance. We performed a systematic review and meta-analysis to identify factors associated with progression of BE without dysplasia or BE with low-grade dysplasia (LGD) to high-grade dysplasia or esophageal adenocarcinoma. METHODS: We performed a systematic search of databases through May 2016 to identify cohort studies of patients with baseline BE without dysplasia or BE with LGD that reported predictors of progression...
November 30, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29193996/genome-wide-association-study-of-rice-grain-width-variation
#12
Xiao-Ming Zheng, Tingting Gong, Hong-Ling Ou, Dayuan Xue, Weihua Qiao, Junrui Wang, Sha Liu, Qingwen Yang, Kenneth M Olsen
Seed size is variable within many plant species, and understanding the underlying genetic factors can provide insights into mechanisms of local environmental adaptation. Here we make use of the abundant genomic and germplasm resources available for rice (<i>Oryza sativa</i>) to perform a large scale genome-wide association study (GWAS) of grain width. Grain width varies widely within the crop and is also known to show climate-associated variation across populations of its wild progenitor. Using a filtered dataset of >1...
December 1, 2017: Genome Génome / Conseil National de Recherches Canada
https://www.readbyqxmd.com/read/29178186/mammary-epithelium-specific-inactivation-of-v-atpase-reduces-stiffness-of-extracellular-matrix-and-enhances-metastasis-of-breast-cancer
#13
Gajendra K Katara, Arpita Kulshrestha, Liqun Mao, Xin Wang, Manoranjan Sahoo, Safaa Ibrahim, Sahithi Pamarthy, Kimiko Suzue, Gajendra S Shekhawat, Alice Gilman-Sachs, Kenneth D Beaman
Extracellular matrix (ECM) critically impacts tumor progression and is influenced by both cancer and host tissue cells. While our understanding of cancer cell ECM remodeling is widespread, the importance of host tissue ECM, which provides initial congenial environment for primary tumor formation, is partly understood. Here, we report a novel role of epithelial cell associated vacuolar-ATPase 'a2' isoform (a2V) in regulating breast tissue ECM stiffness to control metastasis. Using a mammary-gland specific a2V knockout model, we show that in the absence of a2V, breast tumors exhibit atypically soft tumor phenotype, less tumor rigidity and necrotic tumor microenvironment...
November 27, 2017: Molecular Oncology
https://www.readbyqxmd.com/read/29171793/preoperative-skin-antisepsis-with-chlorhexidine-gluconate-versus-povidone-iodine-a-prospective-analysis-of-6959-consecutive-spinal-surgery-patients
#14
George M Ghobrial, Michael Y Wang, Barth A Green, Howard B Levene, Glen Manzano, Steven Vanni, Robert M Starke, George Jimsheleishvili, Kenneth M Crandall, Marina Dididze, Allan D Levi
OBJECTIVE The aim of this study was to determine the efficacy of 2 common preoperative surgical skin antiseptic agents, ChloraPrep and Betadine, in the reduction of postoperative surgical site infection (SSI) in spinal surgery procedures. METHODS Two preoperative surgical skin antiseptic agents-ChloraPrep (2% chlorhexidine gluconate and 70% isopropyl alcohol) and Betadine (7.5% povidone-iodine solution)-were prospectively compared across 2 consecutive time periods for all consecutive adult neurosurgical spine patients...
November 24, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29166588/regulatory-t-cell-migration-is-dependent-on-glucokinase-mediated-glycolysis
#15
Madhav Kishore, Kenneth C P Cheung, Hongmei Fu, Fabrizia Bonacina, Guosu Wang, David Coe, Eleanor J Ward, Alessandra Colamatteo, Maryam Jangani, Andrea Baragetti, Giuseppe Matarese, David M Smith, Robert Haas, Claudio Mauro, David C Wraith, Klaus Okkenhaug, Alberico L Catapano, Veronica De Rosa, Giuseppe D Norata, Federica M Marelli-Berg
Migration of activated regulatory T (Treg) cells to inflamed tissue is crucial for their immune-modulatory function. While metabolic reprogramming during Treg cell differentiation has been extensively studied, the bioenergetics of Treg cell trafficking remains undefined. We have investigated the metabolic demands of migrating Treg cells in vitro and in vivo. We show that glycolysis was instrumental for their migration and was initiated by pro-migratory stimuli via a PI3K-mTORC2-mediated pathway culminating in induction of the enzyme glucokinase (GCK)...
November 21, 2017: Immunity
https://www.readbyqxmd.com/read/29163847/a-relative-increase-in-circulating-platelets-following-chemoradiation-predicts-for-poor-survival-of-patients-with-glioblastoma
#16
Keeratikarn Boonyawan, Kenneth R Hess, Jie Yang, Lihong Long, Qianghu Wang, Ravesanker Ezhilarasan, Alessandra Auia, Kristin D Alfaro-Munoz, John F de Groot, Krishna P Bhat, Erik P Sulman
Background: Thrombocytosis is triggered by and promotes tumor growth. The relationship between the change in circulating platelets after chemoradiation therapy (CRT) or adjuvant temozolomide (TMZ) and survival in glioblastoma remains unclear. We hypothesized that an increase in platelets after these treatments would be predictive of a shorter survival. Methods: We retrospectively reviewed data on 122 patients with newly diagnosed, pathologically proven glioblastoma who had been treated with surgery, followed by CRT and adjuvant TMZ, from 2007 to 2016...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29163813/the-novel-zip4-regulation-and-its-role-in-ovarian-cancer
#17
Qipeng Fan, Qingchun Cai, Pengfei Li, Wenyan Wang, Jing Wang, Emily Gerry, Tian-Li Wang, Ie-Ming Shih, Kenneth P Nephew, Yan Xu
Our RNAseq analyses revealed that ZIP4 is a top gene up-regulated in more aggressive ovarian cancer cells. ZIP4's role in cancer stem cells has not been reported in any type of cancer. In addition, the role and regulation of ZIP4, a zinc transporter, have been studied in the context of extracellular zinc transporting. Factors other than zinc with ZIP4 regulatory effects are essentially unknown. ZIP4 expression and its regulation in epithelial ovarian cancer cells was assessed by immunoblotting, quantitative PCR, or immunohistochemistry staining in human ovarian tissues...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29161585/localized-lysosome-exocytosis-helps-breach-tissue-barriers
#18
Shaohe Wang, Kenneth M Yamada
Cell invasion across basement membrane barriers is important in both normal development and cancer metastasis. In this issue of Developmental Cell, Naegeli et al. (2017) identify a mechanism for breaching basement membranes. Localized lysosome exocytosis fuels generation of large, invasive cellular protrusions that expand tiny basement membrane openings.
November 20, 2017: Developmental Cell
https://www.readbyqxmd.com/read/29149871/near-work-outdoor-activity-and-myopia-in-children-in-rural-china-the-handan-offspring-myopia-study
#19
Zhong Lin, Tie Ying Gao, Balamurali Vasudevan, Kenneth J Ciuffreda, Yuan Bo Liang, Vishal Jhanji, Su Jie Fan, Wei Han, Ning Li Wang
BACKGROUND: The near work and outdoor activity are the most important environmental risk factors for myopia. However, data from Chinese rural children are relatively rare and remain controversial. Therefore, the purpose of this study was to evaluate the relationship of both near work and outdoor activities with refractive error in rural children in China. METHODS: In this cross-sectional study, 572 (65.1%) of 878 children (6-18 years of age) were included from the Handan Offspring Myopia Study (HOMS)...
November 17, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/29145448/steps-to-achieve-quantitative-measurements-of-microrna-using-two-step-droplet-digital-pcr
#20
Erica V Stein, David L Duewer, Natalia Farkas, Erica L Romsos, Lili Wang, Kenneth D Cole
Droplet digital PCR (ddPCR) is being advocated as a reference method to measure rare genomic targets. It has consistently been proven to be more sensitive and direct at discerning copy numbers of DNA than other quantitative methods. However, one of the largest obstacles to measuring microRNA (miRNA) using ddPCR is that reverse transcription efficiency depends upon the target, meaning small RNA nucleotide composition directly effects primer specificity in a manner that prevents traditional quantitation optimization strategies...
2017: PloS One
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