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https://www.readbyqxmd.com/read/29916277/efficacy-of-d-l-methadone-in-the-treatment-of-glioblastoma-in-vitro
#1
Konstantin Brawanski, Gero Brockhoff, Peter Hau, Arabel Vollmann-Zwerenz, Christian Freyschlag, Annette Lohmeier, Markus J Riemenschneider, Claudius Thomé, Alexander Brawanski, Martin A Proescholdt
AIM: Recently, D,L-methadone has been put forward as adjuvant treatment in glioblastoma (GBM). METHODS: We analyzed the μ-opioid receptor expression in a set of GBM cell lines and investigated the efficacy of D,L-methadone alone and in combination with temozolomide (TMZ). Results & conclusion: Expression of the μ-opioid receptor was similar in the tested cell lines. High concentrations of D,L-methadone induced apoptosis in all cell lines and showed treatment interaction with TMZ...
June 19, 2018: CNS Oncology
https://www.readbyqxmd.com/read/29915993/fentanyl-treatment-for-end-of-life-dyspnoea-relief-in-advanced-cancer-patients
#2
Miguel Angel Benítez-Rosario, Inmaculada Rosa-González, Enrique González-Dávila, Emilio Sanz
PURPOSE: We assessed the effects of subcutaneous-endovenous fentanyl on dyspnoea in a cohort of advanced cancer patients. METHODS: We performed a retrospective study in a cohort of advanced cancer patients with dyspnoea at rest who received subcutaneous or intravenous fentanyl. Patients with no shortness of breath at rest or at minimal exertion, no rescue doses per 24 h, were deemed to be responders to fentanyl. The period of assessment was 6 days from the beginning of fentanyl treatment...
June 18, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29915645/kratom-a-dangerous-player-in-the-opioid-crisis
#3
Khadija Tayabali, Colin Bolzon, Paul Foster, Janki Patel, Mohammad Omar Kalim
Kratom use as a herbal supplement is on the rise in the United States, with reported medical outcomes and lethal effects suggesting a public health threat. Even though the Drug Enforcement Administration has included kratom on its drugs of concern list and the FDA has published a press release to identify it as an opioid with a potential for abuse, its therapeutic and side effects are still not well defined in the literature. Here, we present a case of a 32-year-old man with a history of kratom use who became acutely ill with a brief prodromal illness, followed by jaundice and elevated liver enzymes showing a cholestatic picture, and his successful treatment...
2018: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29914717/future-directions-for-medication-assisted-treatment-for-opioid-use-disorder-with-american-indian-alaska-natives
#4
Kamilla L Venner, Dennis M Donovan, Aimee N C Campbell, Dennis C Wendt, Traci Rieckmann, Sandra M Radin, Sandra L Momper, Carmen L Rosa
The U.S. is experiencing an alarming opioid epidemic, and although American Indians and Alaska Natives (AI/ANs) are especially hard hit, there is a paucity of opioid-related treatment research with these communities. AI/ANs are second only to Whites in the U.S. for overdose mortality. Thus, the National Institute on Drug Abuse convened a meeting of key stakeholders to elicit feedback on the acceptability and uptake of medication assisted treatment (MAT) for opioid use disorders (OUDs) among AI/ANs. Five themes from this one-day meeting emerged: 1) the mismatch between Western secular and reductionistic medicine and the AI/AN holistic healing tradition; 2) the need to integrate MAT into AI/AN traditional healing; 3) the conflict between standardized MAT delivery and the traditional AI/AN desire for healing to include being medicine free; 4) systemic barriers; and 5) the need to improve research with AI/ANs using culturally relevant methods...
May 23, 2018: Addictive Behaviors
https://www.readbyqxmd.com/read/29914524/sustaining-alcohol-and-opioid-use-disorder-treatment-in-primary-care-a-mixed-methods-study
#5
Sarah B Hunter, Allison J Ober, Colleen M McCullough, Erik D Storholm, Praise O Iyiewuare, Chau Pham, Katherine E Watkins
BACKGROUND: Efforts to integrate substance use disorder treatment into primary care settings are growing. Little is known about how well primary care settings can sustain treatment delivery to address substance use following the end of implementation support. METHODS: Data from two clinics operated by one multi-site federally qualified health center (FQHC) in the US, including administrative data, staff surveys, interviews, and focus groups, were used to gather information about changes in organizational capacity related to alcohol and opioid use disorder (AOUD) treatment delivery during and after a multi-year implementation intervention was executed...
June 18, 2018: Implementation Science: IS
https://www.readbyqxmd.com/read/29914061/pain-and-pain-medication-among-older-people-with-intellectual-disabilities-in-comparison-with-the-general-population
#6
Anna Axmon, Gerd Ahlström, Hans Westergren
Little is known about pain and pain treatment among people with intellectual disabilities (IDs). We aimed to describe pain and pain medications among older people with ID compared to the general population. Data on diagnoses and prescriptions were collected from national registers for the period between 2006 and 2012 for 7936 people with an ID and a referent cohort from the general population. IDs were associated with a decreased risk of being diagnosed with headaches, musculoskeletal pain, and pain related to the circulatory and respiratory systems, but they were associated with increased risk of being diagnosed with pain related to the urinary system...
June 15, 2018: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/29914002/pain-sensitivity-and-experimentally-induced-sensitisation-in-red-haired-females
#7
Trine Andresen, Dagmar Lunden, Asbjørn M Drewes, Lars Arendt-Nielsen
Introduction and aim Pain sensitivity has been linked to the melanocortin-1 receptor (MC1R) gene. A mutation in MC1R can result in pale skin and red hair in humans and may modulate pain responses in general. Human studies have shown that women with non-functional MC1R's were sensitive to experimental induced cold and heat pain. A study demonstrated that females with red hair required higher dose of anesthesia than females with dark hair to experience analgesia to electrical stimulation. Moreover, women expressing non-functional MC1Rs display greater analgesia from opioid analgesia...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913983/a-6-months-randomised-placebo-controlled-evaluation-of-efficacy-and-tolerability-of-a-low-dose-7-day-buprenorphine-transdermal-patch-in-osteoarthritis-patients-na%C3%A3-ve-to-potent-opioids
#8
Harald Breivik, Tone Marte Ljosaa, Kristian Stengaard-Pedersen, Jan Persson, Hannu Aro, John Villumsen, Dorthe Tvinnemose
Objective Patients with osteoarthritis (OA) pain often have insufficient pain relief from non-opioid analgesics. The aim of this trial was to study efficacy and tolerability of a low dose 7-day buprenorphine transdermal delivery system, added to a NSAID or coxib regimen, in opioid-naïve patients with moderate to severe OA pain. Methods A 6 months randomised, double-blind, parallel-group study at 19 centres in Denmark, Finland, Norway, and Sweden, in which OA patients (>40 years) with at least moderate radiographic OA changes and at least moderate pain in a hip and/or knee while on a NSAID or a coxib were randomised to a 7-day buprenorphine patch (n = 100) or an identical placebo patch (n = 99)...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913911/buprenorphine-clinically-useful-but-often-misunderstood
#9
Stephen Butler
Background There are a number of false myths about buprenorphine based on unconfirmed animal data, even from isolated animal organs, and early clinical research. These myths came into textbooks on pharmacology and pain about 30 years ago and have been difficult to eradicate. Animal models of pain and pain relief are notoriously unreliable as predictors of human clinical effects. The fact is that in clinical practice there is NO bell-shaped dose-response curve, there is NO plateau on the dose-response curve, and there is NO antagonist effect from buprenorphine on other mu-opioid agonists...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913894/evaluation-of-a-novel-chemokine-receptor-2-ccr2-antagonist-in-painful-diabetic-polyneuropathy
#10
Jarkko Kalliomäki, Bror Jonzon, Karin Huizar, Michael O'Malley, Anita Andersson, David M Simpson
Background and aims Preclinical data suggest that the chemokine receptor 2 (CCR2) is involved in the pathophysiology of neuropathic pain through modulation of neuronal excitability, synaptic transmission and activation of spinal cord microglia. CCR2-antagonists have shown to be effective in preclinical models of neuropathic pain. The aim of this study was to evaluate the analgesic efficacy, safety and tolerability of a novel CCR2-antagonist, AZD2423, in patients with painful diabetic neuropathy (PDN). Methods This was a double-blind, randomized, parallel-group, multi-center study in patients with symmetric distal sensory polyneuropathy due to type 1 or 2 diabetes and duration of neuropathic pain between 3 months and 5 years...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913873/postherpetic-neuralgia-new-hopes-in-prevention-with-adult-vaccination-and-in-treatment-with-a-concentrated-capsaicin-patch
#11
Ewa Gawecka, Oddbjørn Viken
Background and purpose Postherpetic neuralgia (PHN) is a complication of acute herpes zoster (HZ). The evidence base for management of PHN has increased by recent publications. Therefore, we reviewed incidence of HZ, prevalence, risk factors, and mechanism of PHN pain, prevention and treatment of PHN with special interest in studies on adult vaccination and topical application of lidocaine and concentrated capsaicin patch. Methods We searched databases with an English language restriction: MEDLINE 1944-2011, EMBASE 1988-2011, PubMed, and the Cochrane Controlled Trial Register and Cochrane Library (2011)...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913859/recovery-after-a-lumbar-disc-herniation-is-dependent-on-a-gender-and-oprm1-asn40asp-genotype-interaction
#12
M B Olsen, L M Jacobsen, E I Schistad, L M Pedersen, L J Rygh, C Røe, J Gjerstad
Background/aims The μ-opioid receptor (OPRM1) is the major target of endogenous opioid peptides and opioid analgesic agents. An important single nucleotide polymorphism (SNP) in this gene is the functional SNP, rs1799971, leading to a substitution of asparagine (Asn) to aspartic acid (Asp) at codon 40 in exon 1. Previous studies have suggested that this SNP may give different phenotypes in males and females. In the present study we therefore investigated whether the OPRM1 Asn40Asp SNP, grouped by gender, could predict clinical outcome regarding progression of pain intensity and disability in patients with discogenic low back pain and sciatica...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913822/comparison-between-ropivacaine-local-infiltration-analgesia-with-ketorolac-or-placebo-for-total-knee-replacement-surgery
#13
K V Andersen, L Nikolajsen, V Haraldsted, N T Andersen, C F Jepsen, K Soeballe
Background/aims Optimal pain treatment with minimal side-effects is essential for early mobilization and recovery in patients undergoing total knee replacement surgery. Local infiltration analgesia (LIA) with local anaesthetic might be effective and adjuncts such as ketorolac may provide additional effects on opioid requirements and pain. We tested the hypothesis that adding ketorolac significantly improves analgesia after total knee replacement surgery. Methods Sixty patients were enrolled in this prospective double-blinded study and allocated to either group R (placebo) or Group RK (ketorolac 120 mg)...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913771/long-term-outcome-of-multidisciplinary-intervention-of-chronic-non-cancer-pain-patients-in-a-private-setting
#14
Villy Meineche-Schmidt, Niels-Henrik Jensen, Per Sjøgren
Background and aim The present study reports on chronic non-cancer patients who were referred to a private pain clinic, according to a waiting time guarantee and treated within one month from referral. Based on evaluation by members of the multidisciplinary staff at our pain clinic a pain management program could be offered individually or as group therapy. Methods Health related quality of life, psychometric tests, use of pain medication; socio-economic status and number of consultations in general practice were recorded at referral to the clinic and by postal questionnaires at follow-up 21 months later...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913762/the-impact-of-chronic-pain-european-patients-perspective-over-12-months
#15
Tony O'Brien, Harald Breivik
Background and methods Pain Study Tracking Ongoing Responses for a Year (PainSTORY) is a longitudinal study generating some quantitative and limited qualitative data concerning the experiences of individual patients with non-malignant chronic pain. Research was conducted across 13 European countries and a total of 294 patients completed the full evaluation process over 12 months. Adult patients (>18 years old) scoring >4 on an 11-point numeric pain rating scale (NRS-11) for most days during an average week were eligible...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913756/predictive-validity-of-pharmacologic-interventions-in-animal-models-of-neuropathic-pain
#16
Per Hartvig Honoré, Anna Basnet, Pernille Kristensen, Lene Munkholm Andersen, Signe Neustrup, Pia Møllgaard, Laila Eljaja, Ole J Bjerrum
Introduction The pathophysiologic and neurochemical characteristics of neuropathic pain must be considered in the search for new treatment targets. Breakthroughs in the understanding of the structural and biochemical changes in neuropathy have opened up possibilities to explore new treatment paradigms. However, long term sequels from the damage are still difficult to treat. Aim of the study To examine the validity of pharmacological treatments in humans and animals for neuropathic pain. Method An overview from the literature and own experiences of pharmacological treatments employed to interfere in pain behavior in different animal models was performed...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913751/parenteral-opioids-in-emergency-medicine-a-systematic-review-of-efficacy-and-safety
#17
Leila Niemi-Murola, Jani Unkuri, Katri Hamunen
Introduction and aim Pain is a frequent symptom in emergency patients and opioids are commonly used to treat it at emergency departments and at pre-hospital settings. The aim of this systematic review is to examine the efficacy and safety of parenteral opioids used for acute pain in emergency medicine. Method Qualitative review of randomized controlled trials (RCTs) on parenteral opioids for acute pain in adult emergency patients. Main outcome measures were: type and dose of the opioid, analgesic efficacy as compared to either placebo or another opioid and adverse effects...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913706/evaluation-of-spinal-interventions-in-a-single-doctor-private-practice-in-sweden
#18
Leif Måwe, Lena Thorén, Jan Persson
Aims To evaluate the effect of spinal interventions following ISIS guidelines [1]. Methods Data from all patients from April 2012 until February 2014 have been registered and followed up after 4-6 months. Patients were mainly referred from surgeons at the regional hospitals. Employment status, medication, VAS, EQ-5D-5L, EQ-VAS and pain reduction were gathered before and at the follow-up. Only patients receiving any kind of treatment were included. Results So far 419/823 patients have been followed-up. Here we present levels of medication and total pain reduction for all patients and, separately, for patients treated with radio frequency facet joint medial branch neurotomy (n = 76)...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913688/inflammation-reactive-astrocytes-can-be-restored-with-a-three-drug-combination
#19
E Hansson, L Block, U Björklund, B Biber
Aims In inflammation-reactive astrocytes the cell parameters, Ca2+ signalling, Na+ transporters, cytoskeleton, and release of proinflammatory cytokines are affected. We want to re-establish these parameters with agents, which might have a potential to restore the cells back to a normal non-inflammatory level. Methods Astrocytes in primary cultures were incubated with lipopolysaccharide (LPS) (10 ng/ml) for 24 h to become inflammation-reactive. Different parameters were analysed to verify this inflammation: Ca2+ signalling, Na+/K+-ATPase expression, actin filament organization, and interleukin-1beta release (IL-1β)...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913668/effects-of-prolonged-release-oxycodone-naloxone-on-pain-control-bowel-function-and-quality-of-life-a-prospective-observational-study
#20
Sabine Hesselbarth, Oliver Löwenstein, Thomas Cegla
Background and aim Strong opioids including oxycodone are amongst the most effective analgesics to combat moderate to severe pain of various aetiologies, but opioid-induced bowel dysfunction (OIBD) represents a relevant problem. The rationale for development of a prolonged-release (PR) fixed combination of oxycodone and naloxone was to counteract OIBD. Due to its negligible oral bioavailability, the μ-opioid receptor antagonist naloxone is able to selectively displace opioids from local μ-receptors in the gastrointestinal tract without affecting central opioid binding sites...
December 29, 2017: Scandinavian Journal of Pain
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