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https://www.readbyqxmd.com/read/28819618/serum-levels-of-cyfra-21-in-patients-with-benign-and-malignant-salivary-gland-tumors
#1
Naghmeh Jeiroodi, Seyed Mohammad-Javad Aslani, Bijan Khademi, Mahyar Malekzadeh, Zohreh Jaafari-Ashkavandi
INTRODUCTION: Cyfra 21 is a serum-soluble fragment of cytokeratin19. Increased Cyfra 21 serum levels and their benefit as a tumor marker have been shown in some malignancies. This study aimed to evaluate the serum levels of Cyfra 21 in patients with benign and malignant salivary gland tumors. MATERIALS AND METHODS: In this cross-sectional study, the serum level of Cyfra 21 in 44 patients with malignant salivary gland tumors and 16 cases of pleomorphic adenoma were compared with 28 healthy controls using enzyme-linked immunosorbent assay (ELISA)...
July 2017: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28816958/effective-apatinib-treatment-of-pleomorphic-liposarcoma-a-case-report
#2
Peng Yan, Mei-Li Sun, Yu-Ping Sun, Chuan-Yong Liu
RATIONALE: Pleomorphic liposarcoma (PLS) is a rare and aggressive malignant tumor, and both radiation and conventional cytotoxic chemotherapy remain controversial for metastatic or unresectable disease. PATIENT CONCERNS: We presented an 81-year-old Chinese woman with advanced PLS who received apatinib after failure chemotherapy. DIAGNOSES: The patient was diagnosed as having PLS by biopsy. INTERVENTIONS: After a failed chemotherapy, apatinib started to be taken orally 425 mg per day...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28816366/modification-of-the-paris-system-for-urinary-tract-washing-specimens-using-diagnostic-cytological-features
#3
J Suh, H Go, C Sung, S Baek, H Hwang, S Jeong, Y Cho
OBJECTIVE: The Paris System (TPS), which was recently introduced, emphasised the key features of malignant urine cytology: a high nuclear to cytoplasmic ratio, nuclear hyperchromasia, irregular nuclear membranes and coarse chromatin. Although other diagnostic features have been described, the diagnostic significance of such features and their application to TPS have not been fully defined for urinary tract washing specimens. METHODS: A total of 142 cases of urinary tract washing specimens with corresponding surgical pathology samples were examined for the key features of TPS and 13 previously described features...
August 17, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/28815663/who-2016-classification-of-gliomas
#4
Pieter Wesseling, David Capper
Gliomas are the most frequent intrinsic tumours of the central nervous system and encompass two principle subgroups: diffuse gliomas and gliomas showing a more circumscribed growth pattern ('non-diffuse gliomas'). In the revised 4th edition of the WHO Classification of CNS tumors published in 2016, classification of especially diffuse gliomas has fundamentally changed: for the first time a large subset of these tumours is now defined based on presence/absence of IDH mutation and 1p/19q codeletion. Following this approach, the diagnosis of (anaplastic) oligoastrocytoma can be expected to largely disappear...
August 16, 2017: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/28815579/-histological-characteristics-of-hpv-associated-and-independent-squamous-cell-carcinomas-of-the-vulva-a-study-of-1594-cases
#5
Natalia Rakislova, Omar Clavero, Laia Alemany, Adela Saco, Beatriz Quirós, Belen Lloveras, Maria Alejo, Michael Pawlita, Wim Quint, Marta Del Pino, Silvia de Sanjose, Jaume Ordi
There are at least two different etio-pathogenic pathways for the development of vulvar squamous cell carcinoma (VSCC): one associated with infection by human papillomavirus (HPV) and another independent of HPV. We aimed to describe the histological characteristics of HPV-associated and HPV-independent tumors and to determine the best strategy to identify HPV in VSCC. A single paraffin block was available for review from a series of 1594 VSCCs. In all cases HPV DNA detection was analyzed using the SPF10PCR/DEIA/LiPA25 system and p16 immunohistochemistry (IHC)...
August 17, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28814294/canine-intrathoracic-sarcoma-with-ultrastructural-characteristics-of-human-synovial-sarcoma-case-report
#6
Ser Lovell, R K Burchell, P J Roady, R L Fredrickson, A Gal
BACKGROUND: Canine joint sarcomas, designated synovial sarcomas, are uncommon malignant mesenchymal neoplasms that occur in the large joints of the extremities of middle-aged, large-breed dogs. We report the diagnosis of an intrathoracic sarcoma with ultrastructural characteristics reminiscent of human synovial sarcoma in a dog. CASE PRESENTATION: A 7-year-old female spayed Tibetan terrier crossbred dog was presented for acute severe labored breathing and diagnosed with an intrathoracic neoplastic mass...
August 16, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28812533/immunoreactivity-of-canine-liposarcoma-to-muscle-and-brown-adipose-antigens
#7
Elise Eva Bella LaDouceur, Sarah E Stevens, Jason Wood, Christopher M Reilly
Liposarcoma, rhabdomyosarcoma, and hibernoma share some overlapping histologic and immunohistochemical features. Although immunohistochemistry (IHC) is commonly used in the diagnosis of these neoplasms, expression of muscle markers has been reported in human liposarcoma and canine hibernoma in addition to rhabdomyosarcoma. Thus, these neoplasms are a diagnostic challenge but important to distinguish because of differences in prognosis and treatment. Rhabdomyosarcoma and liposarcoma are both malignant, but rhabdomyosarcoma has a higher potential for metastasis...
January 1, 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/28812461/soft-tissue-perineurioma-in-a-child-with-neurofibromatosis-type-1-a-case-report-and-review-of-the-literature
#8
Mudher Al-Adnani
Soft tissue perineurioma is a rare benign peripheral nerve sheath tumor, especially in children. This manuscript presents an unusual case of soft tissue perineurioma in a 10-year-old boy with neurofibromatosis type 1. The patient presented with a lump in the region of the right breast. A subcutaneous, well circumscribed mass was removed. The cut surface was cream with a vaguely nodular appearance. Histology showed a spindle cell lesion with variable architecture and biphasic morphology. There was no nuclear atypia or pleomorphism...
September 2017: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/28806631/unraveling-complex-relationships-among-dysphoric-disorder-localization-related-epilepsy-and-mood-disorders
#9
Tetsufumi Suda, Yasutaka Tatsuzawa, Taichi Mogi, Aihide Yoshino
BACKGROUND: Dysphoric disorder (DD), characterized by intermittent pleomorphic symptoms, has been believed to be specific to epilepsy. However, our previous study revealed that DD in patients with localization-related epilepsy was associated with a lifetime diagnosis of mood disorders. The present study was conducted to estimate the prevalence of DD in patients with mood disorders, but not epilepsy, and to identify the clinical similarities and differences of DD in patients with either epilepsy or mood disorders...
August 11, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28805986/histiocytic-sarcoma-new-insights-into-fna-cytomorphology-and-molecular-characteristics
#10
Yin P Hung, Scott B Lovitch, Xiaohua Qian
BACKGROUND: Histiocytic sarcoma (HS) is a rare malignant neoplasm showing morphologic and immunophenotypic features of histiocytes. Molecular characteristics of HS and fine-needle aspiration (FNA) criteria for its diagnosis have not been established. METHODS: A case series of HS in 8 FNA samples from 6 patients was reviewed along with histopathologic and clinical data. Immunohistochemistry was performed on cell blocks (3 cases), core biopsies (5 cases), and surgical specimens (4 cases)...
August 2017: Cancer
https://www.readbyqxmd.com/read/28802505/soft-tissue-tumors-of-uncertain-histogenesis-a-review-for-dermatopathologists
#11
REVIEW
Darya Buehler, Paul Weisman
The mesenchymal tumors discussed herein represent a heterogeneous group of neoplasms with distinctive morphologic, immunophenotypic, and molecular genetic features. These uncommon tumors often arise in the dermis and subcutis and can pose a major diagnostic challenge to dermatopathologists because they closely mimic melanoma, carcinoma, fibrous histiocytoma, schwannoma, or granulomatous inflammation. This article reviews the clinical presentation, histopathology, differential diagnosis, and diagnostic pitfalls of epithelioid sarcoma, clear cell sarcoma, perivascular epithelioid cell tumor, ossifying fibromyxoid tumor, pleomorphic hyalinizing angiectatic tumor, and hemosiderotic fibrolipomatous tumor...
September 2017: Clinics in Laboratory Medicine
https://www.readbyqxmd.com/read/28796899/plag1-immunohistochemistry-is-a-sensitive-marker-for-pleomorphic-adenoma-a-comparative-study-with-plag1-genetic-abnormalities
#12
Nora Katabi, Bin Xu, Achim A Jungbluth, Lei Zhang, Sung Yun Shao, Jason Lane, Ronald Ghossein, Cristina R Antonescu
AIMS: PLAG1 gene rearrangement is the most common genetic abnormality in pleomorphic adenoma (PA), resulting in overexpression of PLAG1 protein. PA and carcinoma ex pleomorphic adenoma (CA ex-PA) can mimic various benign and malignant salivary gland tumors. The aims of this study are to evaluate the sensitivity and specificity of PLAG1 immunohistochemistry (IHC) in the differential diagnosis of PA and CA ex-PA and to compare the PLAG1 immunohistochemical results to PLAG1 gene abnormalities as detected by fluorescence in situ hybridization (FISH)...
August 10, 2017: Histopathology
https://www.readbyqxmd.com/read/28791066/corneal-alterations-associated-with-pseudoexfoliation-syndrome-and-glaucoma-a-literature-review
#13
REVIEW
Joel R Palko, Owen Qi, Arsham Sheybani
A systematic literature review was performed evaluating articles examining the effects of pseudoexfoliation syndrome (PEX) and glaucoma (PEXG) on the cornea with a focus on the corneal endothelium. We searched for articles relevant to pseudoexfoliation syndrome, pseudoexfoliation glaucoma and corneal endothelial cell counts using Pubmed, Google Scholar Database, Web of Science and Cochrane Library databases published prior to September of 2016. We then screened the references of these retrieved papers and performed a Web of Science cited reference search...
July 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/28782639/the-differential-diagnosis-between-pleural-sarcomatoid-mesothelioma-and-spindle-cell-pleomorphic-sarcomatoid-carcinomas-of-the-lung-evidence-based-guidelines-from-the-international-mesothelioma-panel-and-the-mesopath-national-reference-center
#14
Alberto M Marchevsky, Nolwenn LeStang, Kenzo Hiroshima, Giuseppe Pelosi, Richard Attanoos, Andrew Churg, Lucien Chirieac, Sanja Dacic, Aliya Husain, Andras Khoor, Sonja Klebe, Silvie Lantuejoul, Victor Roggli, Jean-Michel Vignaud, Birgit Weynand, Jennifer Sauter, Douglas Henderson, Kazuki Nabeshima, Francoise Galateau-Salle
Immunohistochemistry is used to distinguish sarcomatoid malignant mesotheliomas (SMM) from spindle cell and pleomorphic carcinomas (SPC) but there are no guidelines on how to interpret cases that show overlapping or equivocal immunohistochemical findings. A systematic literature review of the immunophenotype of these lesions was performed and the experience with 587 SMM and 46 SPC at MESOPATH was collected. Data were analyzed with Comprehensive Meta-Analysis 2.0 software (Biostast, Englewood N.J.). There were insufficient data to evaluate the differential diagnosis between SPC and localized SMM or peritoneal SMM...
August 4, 2017: Human Pathology
https://www.readbyqxmd.com/read/28772134/expression-of-c-x-c-motif-chemokine-receptors-4-and-7-in-salivary-gland-neoplasms
#15
Ekarat Phattarataratip, Kittipong Dhanuthai
OBJECTIVES: Chemokine receptors have been shown to overexpress in several cancer types. Binding of chemokines to their cognate chemokine receptors on tumor cells can promote tumor growth, angiogenesis and metastasis. The purposes of this study was to examine the expression of chemokine receptors, CXCR4 and CXCR7, in salivary gland neoplasms and its association with pathologic characteristics. DESIGN: Sixty-two cases of salivary gland neoplasms, including 25 mucoepidermoid carcinomas (MEC), 18 adenoid cystic carcinomas (ACC), 14 pleomorphic adenomas (PA) and 5 polymorphous low-grade adenocarcinoma (PLGA) were investigated for CXCR4 and CXCR7 expression immunohistochemically...
July 26, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28764610/synovial-sarcoma-mimicking-pleomorphic-hyalinizing-angiectatic-tumor-of-soft-parts-a-case-report
#16
Neha Gupta, Samuel Kenan, Leonard B Kahn
Synovial sarcoma is a high-grade sarcoma commonly affecting young adults. The sites of involvement include soft tissue near joints, lung, pleura, mediastinum, larynx, kidney, and buttocks. Histologic types include monophasic, biphasic, and undifferentiated. We report a unique case of synovial sarcoma with low-grade histologic features mimicking pleomorphic hyalinizing angiectatic tumor (PHAT) with indolent behavior for a period of 10 years. The tumor showed angiectatic blood vessels with fibrinous cuffing, hypocellular and hypercellular spindle cell areas with rare mitoses, and focal atypia in a myxoid background...
August 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28762020/conception-and-management-of-a-poorly-understood-spectrum-of-dermatologic-neoplasms-atypical-fibroxanthoma-pleomorphic-dermal-sarcoma-and-undifferentiated-pleomorphic-sarcoma
#17
REVIEW
Teo Soleymani, S Tyler Hollmig
Atypical fibroxanthoma (AFX) and pleomorphic dermal sarcoma (PDS) tumors share many clinical, etiologic, and histologic features and likely represent components of a tumor spectrum. In dermatologic oncology, differentiating between AFX and PDS is pivotal as tumors with histological features consistent with PDS are more likely to behave in a clinically aggressive manner. Importantly, the term "pleomorphic dermal sarcoma" (PDS) is a more appropriate designation than "undifferentiated pleomorphic sarcoma" (UPS) for describing deeper, more aggressive, histologically high-grade cutaneous tumors that otherwise resemble AFX...
August 2017: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/28761985/synovial-sarcoma-showing-loss-of-a-green-signal-in-ss18-fluorescence-in-situ-hybridization-a-clinicopathological-and-molecular-study-of-12-cases
#18
Dan Jiang, Ran Peng, Xiaochu Yan, Min Chen, Ting Lan, Huijiao Chen, Zhang Zhang, Wenyi Jing, Lili Jiang, Limei Ma, Hongying Zhang
The phenomenon of losing a green signal in synovial sarcoma (SS) using the SS18 break-apart probe by fluorescence in situ hybridization (FISH) has been poorly described. In this study, 12 SS with missing a green signal were identified. This series included 7 males and 5 females, aged 17 to 69 years (median, 38.5 years). The tumors involved the extremities (50%), mediastinum (16.7%), hypopharynx (8.3%), neck (8.3%), thyroid (8.3%), and retroperitoneum (8.3%). The tumors were classified as monophasic SS (58...
July 31, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28761545/primary-pleomorphic-xanthoastrocytoma-of-the-spinal-cord-a-case-report-and-review-of-literature
#19
Mayur Sharma, Vernon Velho, Rachana Binayake, Hrushikesh Kharosekar
Primary pleomorphic xanthoastrocytoma (PXA) of the spinal cord is a rare slow growing tumor. To our knowledge, only five such cases have been reported in the literature till date. We report the clinical, radiological, and histopathological features of a spinal PXA in a 23-year-old female previously operated 5 years back for a spinal tumor, presented with weakness in lower limbs, sphincter incontinence and low back pain. Magnetic resonance imaging scan with contrast reveals an intramedullary lesion in the spinal cord from D8-D10 level...
July 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28759137/soft-tissue-sarcomas-from-a-morphological-to-a-molecular-biological-approach
#20
REVIEW
Yoshinao Oda, Hidetaka Yamamoto, Kenichi Kohashi, Yuichi Yamada, Kunio Iura, Takeaki Ishii, Akira Maekawa, Hirofumi Bekki
Recently developed molecular genetic techniques have led to the elucidation of tumor-specific genomic alterations and thereby the reclassification of tumor entities of soft tissue sarcoma. A solitary fibrous tumor-mimicking tumor with the AHRR-NCOA2 gene has been isolated as angiofibroma of soft tissue. As for small round cell sarcomas, novel fusion genes such as CIC-DUX4 and BCOR-CCNB3 have been identified in these tumor groups. SMARCB1/INI1 deficient tumors with round cell morphology are also expected to be reclassified in three types, based on the combination of their morphology and genotype...
July 31, 2017: Pathology International
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