keyword
https://read.qxmd.com/read/38536068/best-overall-response-associated-signature-to-doxorubicin-in-soft-tissue-sarcomas-a-transcriptomic-analysis-from-announce
#1
JOURNAL ARTICLE
Jiangang Liu, David S Moura, Robin L Jones, Amit Aggarwal, Ebert J Philip, Andrew J Wagner, Jennifer Wright, Javier Martín-Broto, William D Tap
PURPOSE: This exploratory analysis evaluated the tumor samples of the patients treated with doxorubicin (with or without olaratumab) in a negative phase-3 ANNOUNCE trial to better understand the complexity of advanced soft tissue sarcomas (STS) and to potentially identify its predictive markers. EXPERIMENTAL DESIGN: RNA sequencing was performed on pretreatment tumor samples (n=273) from the ANNOUNCE trial to evaluate response patterns and identify potential predictive treatment markers for doxorubicin...
March 27, 2024: Clinical Cancer Research
https://read.qxmd.com/read/38535559/current-role-of-surgery-in-the-treatment-of-neurocysticercosis
#2
REVIEW
Pedro Tadao Hamamoto Filho, Luiz Fernando Norcia, Agnès Fleury, Marco Antônio Zanini
Neurocysticercosis (NCC) is a common parasitic disease of the central nervous system (CNS) in low- and middle-income countries. The infection is pleomorphic, caused by the larval form of the cestode, Taenia solium , and part of the heterogeneity of its clinical presentations is associated with the localization of the parasite within the CNS. Changes in the current epidemiological trends of NCC indicate that extra-parenchymal NCC is proportionally becoming more frequent. Extraparenchymal NCC is commonly accompanied by raised intracranial hypertension due to hydrocephalus, which is an emergency requiring cyst extirpation by surgical intervention to relieve the symptoms...
February 29, 2024: Pathogens
https://read.qxmd.com/read/38535080/differences-in-histological-subtypes-of-invasive-lobular-breast-carcinoma-according-to-immunohistochemical-molecular-classification
#3
JOURNAL ARTICLE
Ivan Ilić, Jana Cvetković, Ratko Ilić, Ljubiša Cvetković, Aleksandar Milićević, Stefan Todorović, Pavle Ranđelović
UNLABELLED: The technical complexity of gene expression profiling in routine practice has necessitated the use of surrogate molecular classification of breast cancer, based on immunohistochemical analyses. BACKGROUND AND OBJECTIVES: The aim of this study was to compare the differences between histological and molecular subtypes of invasive lobular carcinoma (ILC) of the breast, in order to be able to predict the behavior and prognosis of the disease, as well as to effectively determine therapy...
March 21, 2024: Diagnostics
https://read.qxmd.com/read/38532076/follicular-dendritic-cell-sarcoma-arising-from-the-lymph-node-of-the-pancreatic-head-a-case-report-with-literature-review
#4
JOURNAL ARTICLE
Takahiro Yamada, Keinosuke Ishido, Norihisa Kimura, Taiichi Wakiya, Hayato Nagase, Shintaro Goto, Tadashi Yoshizawa, Hiroshi Kijima, Seiichi Kato, Kenichi Hakamada
A 72-year-old man was referred to our hospital for the examination of a pancreatic head mass. Abdominal computed tomography revealed a contrasted 8-cm-diameter tumor extending from the dorsal pancreatic head to the porta hepatis. The preoperative diagnosis was challenging due to the absence of specific imaging findings and the inability to perform a biopsy. Positron emission tomography/computed tomography and diffusion-weighted imaging suggested a malignant tumor originating from the organs surrounding the pancreatic head...
March 26, 2024: Clinical Journal of Gastroenterology
https://read.qxmd.com/read/38530111/a-low-risk-hpv-associated-well-differentiated-squamous-cell-carcinoma-of-the-cervix-with-low-grade-squamous-intraepithelial-lesion-morphology-clinical-and-pathologic-diagnostic-difficulties-and-review-of-the-literature
#5
JOURNAL ARTICLE
Deniz Ates, Esra Nur Sahin, Kübra Katipoglu, Alp Usubutun
Approximately 95% of cervical squamous cell carcinomas are associated with high-risk HPV, with a small number of HPV-independent tumors. However, low-risk HPV types have also been detected in rare cervical squamous cell carcinomas. Low-grade squamous intraepithelial lesion-related changes are a rare morphologic finding in cervical squamous cell carcinoma. We present the case of a 30-yr-old woman who presented with pelvic pain and foul-smelling vaginal discharge showing an exophytic lesion protruding from the cervix...
March 26, 2024: Türk Patoloji Dergisi
https://read.qxmd.com/read/38528849/a-unique-presentation-site-of-pleomorphic-adenoma-in-a-young-woman-a-case-report
#6
Faryal S Rasheed, Rakan H Alelyani, Hana A Alazzmi, Emad A Alfadhel, Sultan N Alaqil, Hussain A Alobaidi, Othillah M Moazin, Haifa M Alshammari, Tanveer A Bhaat, Eyad A Nawwab
The expression "pleomorphic adenoma" has been used synonymously with mixed cutaneous tumors and chondroid syringomas. It originates from eccrine or apocrine skin, salivary glands, and lacrimal glands. Histologically, it comprises an epithelial-lined glandular component embedded in the cartilaginous, myxomatous, or fibrous stroma. These lesions are usually misdiagnosed because they are extremely rare. It commonly affects middle-aged men and has a slow-growing nature. The usual manifestation is a firm nodular lesion in the periorbital region, particularly at eyelid margins...
March 2024: Plastic and Reconstructive Surgery. Global Open
https://read.qxmd.com/read/38525319/-ret-fusion-testing-in-patients-with-nsclc-the-reting-study
#7
JOURNAL ARTICLE
Esther Conde, Susana Hernandez, Jose Luis Rodriguez Carrillo, Rebeca Martinez, Marta Alonso, Daniel Curto, Beatriz Jimenez, Alejandra Caminoa, Amparo Benito, Pilar Garrido, Sergi Clave, Edurne Arriola, Isabel Esteban-Rodriguez, Javier De Castro, Irene Sansano, Enriqueta Felip, Federico Rojo, Manuel Dómine, Ihab Abdulkader, Jorge Garcia-Gonzalez, Cristina Teixido, Noemi Reguart, Desamparados Compañ, Amelia Insa, Nuria Mancheño, Sarai Palanca, Oscar Juan-Vidal, Nuria Baixeras, Ernest Nadal, Maria Cebollero, Antonio Calles, Paloma Martin, Clara Salas, Mariano Provencio, Ignacio Aranda, Bartomeu Massuti, Laura Lopez-Vilaro, Margarita Majem, Luis Paz-Ares, Fernando Lopez-Rios
INTRODUCTION: RET inhibitors with impressive overall response rates are now available for patients with NSCLC, yet the identification of RET fusions remains a difficult challenge. Most guidelines encourage the upfront use of next-generation sequencing (NGS), or alternatively, fluorescence in situ hybridization (FISH) or reverse transcriptase-polymerase chain reaction (RT-PCR) when NGS is not possible or available. Taken together, the suboptimal performance of single-analyte assays to detect RET fusions, although consistent with the notion of encouraging universal NGS, is currently widening some of the clinical practice gaps in the implementation of predictive biomarkers in patients with advanced NSCLC...
April 2024: JTO clinical and research reports
https://read.qxmd.com/read/38525121/a-22-year-single-institution-review-of-119-cases-of-salivary-duct-carcinoma
#8
JOURNAL ARTICLE
Ethan J Han, Laith A Mukdad, Yazeed Alhiyari, Morcos N Nakhla, Dipti P Sajed, Maie A St John
OBJECTIVE: Salivary duct carcinoma (SDC) is a rare and aggressive salivary gland malignancy. Herein, we present the largest single-institution review of SDC to date. METHODS: This is a retrospective cohort study of all histologically confirmed cases of SDC seen at our institution from January 1, 2002, to August 1, 2022. Patient demographics, treatment, histological characteristics, tumor staging, and outcomes were extracted from the electronic medical record. Kaplan-Meier and Cox regression survival analyses were performed...
April 2024: Laryngoscope Investigative Otolaryngology
https://read.qxmd.com/read/38521165/neutrophil-to-lymphocyte-ratio-for-the-prediction-of-soft-tissue-sarcomas-response-to-pre-operative-radiation-therapy
#9
JOURNAL ARTICLE
Constanza Martinez, Rie Asso, Neelabh Rastogi, Carolyn Freeman, Fabio Cury
PURPOSE/OBJECTIVE: This study aims to assess the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) in soft tissue sarcomas (STS) treated with pre-operative hypofractionated radiotherapy (HFRT). MATERIALS/METHODS: This retrospective analysis included patients treated with pre-operative HFRT of 30 Gy in 5 fractions between 2016 and 2023. Clinical, demographic, and complete blood count (CBC) data were collected. NLR was calculated by dividing the absolute neutrophil count by the absolute lymphocyte count...
March 21, 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38513191/comparison-of-clinicopathological-features-of-pleomorphic-and-invasive-lobular-breast-carcinomas
#10
JOURNAL ARTICLE
Mehmet F Sağdıç, Onur C Güler, Orkun Subaşı, Özhan Albayrak, Cihangir Özaslan
PURPOSE: Accounting for about 15% of invasive lobular carcinomas and 1% of breast carcinomas, pleomorphic lobular carcinoma is known to be a rare histological subtype of invasive lobular carcinoma. Yet, it is more aggressive and produces a worse prognosis than other breast cancers. Ultimately, the present study compares the clinicopathological features of pleomorphic and invasive lobular breast carcinomas. METHODS: In the study, we retrospectively evaluated the data of 262 patients with histological subtypes of classical and pleomorphic lobular cancers having been recruited for surgical operations...
March 21, 2024: American Surgeon
https://read.qxmd.com/read/38510015/pdp-type-brain-tumor-in-association-with-multiple-endocrine-neoplasia-type-1
#11
Halldór Bjarki Einarsson, Anja Lisbeth Frederiksen, Inge Soekilde Pedersen, Marianne Schmidt Ettrup, Martin Wirenfeldt, Henning Boldt, Nina Nguyen, Marianne Skovsager Andersen, Carsten Reidies Bjarkam, Frantz Rom Poulsen
Multiple endocrine neoplasia type 1 (MEN1) is a rare autosomal dominant syndrome caused by inactivating pathogenic variants in the tumor suppressor gene menin 1 on chromosome 11q13 (Falchetti et al., 2009). The syndrome is characterized by neoplasia in two or more endocrine glands and has a high degree of penetrance. Pathogenic germline multiple neoplasia type 1 variants primarily result in neoplasia affecting the parathyroid glands, the pancreatic islet cells, and the anterior pituitary in combination. Primary hyperparathyroidism is the most common pathological manifestation of the syndrome, followed by pancreatic neuroendocrine tumors...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38509869/testicular-primary-well-differentiated-neuroendocrine-tumor-clinicopathologic-immunohistochemical-and-molecular-characterization-of-two-patients
#12
JOURNAL ARTICLE
Liwei Jia, Bo Zhang, Daniel Shen, Prasad R Koduru
Well-differentiated neuroendocrine tumor rarely occurs as a testicular primary tumor, accounting for less than 1% of all testicular cancers, and is rarely reported with sufficient molecular profiles. After searching our departmental database (2003-2023), two testicular primary well-differentiated neuroendocrine tumors were identified in a 35-year-old man and a 23-year-old man, respectively, both of whom had normal serum level of tumor markers. Both tumors grossly exhibited solid, yellow-tan, and homogeneous appearance and histologically displayed a mixture of growth patterns, including organoid, tubular, cribriform, nests, cords, and single cells, were composed of eosinophilic tumor cells with salt-and-pepper chromatin and indistinct cell borders...
March 21, 2024: International Journal of Surgical Pathology
https://read.qxmd.com/read/38503406/in-vivo-confocal-microscopy-findings-after-descemet-stripping-only-with-and-without-topical-ripasudil-supplementation-in-fuchs-endothelial-dystrophy
#13
JOURNAL ARTICLE
Luke C Northey, Cameron Oliver, Tanya Trinh, Raj N Devasahayam, Barbara Burgos-Blasco, Gregory Moloney
PURPOSE: To report corneal epithelial and corneal endothelial cell (CEC) changes following Descemet stripping only (DSO) with and without topical ripasudil using in vivo confocal microscopy (IVCM). METHODS: Prospective interventional case series of patients who underwent DSO for Fuchs endothelial dystrophy with or without postoperative topical ripasudil (4%, 6 times per day). Patients underwent IVCM (ConfoScan 3; NIDEK Technologies, Padova, Italy) at baseline, monthly until corneal clearance, and then every 6 months...
March 16, 2024: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://read.qxmd.com/read/38500901/unraveling-the-clinicopathological-diversity-and-subtypes-of-rhabdomyosarcoma-a-study-from-a-tertiary-care-center
#14
JOURNAL ARTICLE
Harika Mandava, Inuganti Venkata Renuka, Sudhakar Ramamoorthy
Background and objective Rhabdomyosarcoma (RMS) is a rare and malignant mesenchymal tumor characterized by skeletal muscle differentiation. While it is a common soft tissue sarcoma in children, its incidence significantly decreases with advancing age, rendering it exceptionally rare in individuals aged more than 45 years. This study aimed to shed light on the clinicopathological diversity and subtypes of RMS, thereby providing a comprehensive overview for enabling diagnostic precision and therapeutic strategies in treating this infrequently encountered malignancy in adults...
February 2024: Curēus
https://read.qxmd.com/read/38500382/a-rare-case-report-of-intraosseous-spindle-and-epithelioid-rhabdomyosarcoma-with-tfcp2-rearrangement-a-pathological-diagnostic-conundrum-and-literature-review
#15
JOURNAL ARTICLE
Cheng Si, Yihuan Wang, Jinghua Zhu
Rhabdomyosarcoma is a highly malignant tumor with striated muscle differentiation, which is histologically classified as alveolar, embryonal, pleomorphic, and spindle cell/sclerosing histological subtype. Rhabdomyosarcoma with TFCP2 rearrangement, which usually occurs in the bone, is a newly identified rare spindle and epithelioid rhabdomyosarcoma with characteristic clinicopathological features and molecular alterations. We report a 39-year-old female patient who underwent local excision of the mandibular lesion...
March 18, 2024: International Journal of Surgical Pathology
https://read.qxmd.com/read/38498193/correlation-between-mri-dwi-and-dce-and-cellularity-of-parotid-gland-pleomorphic-adenomas
#16
JOURNAL ARTICLE
Laura Monestier, Jean Del Grande, Ralph Haddad, Laure Santini, Justin Michel, Arthur Varoquaux, Nicolas Fakhry
PURPOSE: Parotid pleomorphic adenomas present a risk of recurrence, higher when the tumour is a hypocellular subtype. The aim of the study was to determine whether it is possible to characterize this histological subtype with diffusion and perfusion sequences of the preoperative MRI. METHODS: This retrospective study included 97 patients operated between 2010 and 2020. Histologic slides review was performed to classify tumours into three histologic subtypes: hypocellular, classical and hypercellular...
March 18, 2024: European Archives of Oto-rhino-laryngology
https://read.qxmd.com/read/38497430/characterization-of-a-molecularly-distinct-subset-of-oncocytic-pleomorphic-adenomas-myoepitheliomas-harboring-recurrent-zbtb47-as1-plag1-gene-fusion
#17
JOURNAL ARTICLE
Ziyad Alsugair, Jimmy Perrot, Françoise Descotes, Jonathan Lopez, Anne Champagnac, Daniel Pissaloux, Claire Castain, Mihaela Onea, Philippe Céruse, Pierre Philouze, Charles Lépine, Marie-Delphine Lanic, Marick Laé, Valérie Costes-Martineau, Nazim Benzerdjeb
Recurrent gene fusions are common in salivary gland tumors including benign tumors, such as pleomorphic adenoma (PA) and myoepithelioma (ME). In cases where chromosomal rearrangement is identified in the pleomorphic adenoma gene 1 (PLAG1) gene, different gene partners are found. Oncocytic metaplasia, characterized by oncocytes with abundant eosinophilic granular cytoplasm and hyperchromatic nuclei, is a well-known phenomenon in salivary gland neoplasms. However, the pure oncocytic variant of PA/ME showed PLAG1 gene rearrangements involving various gene partners at the molecular level, without any recurrent fusion being found...
March 18, 2024: American Journal of Surgical Pathology
https://read.qxmd.com/read/38496764/case-report-primary-pulmonary-low-grade-fibromyxoid-sarcoma-progressing-to-dedifferentiation-probably-due-to-tp53-driver-mutation
#18
Jiawen Zhang, Haisheng Fang, Xiaomei Zhu, Chenchen Yao, Qinhe Fan, Qixing Gong
Low Grade Fibromyxoid Sarcoma (LGFMS), a rare entity characterized by bland histologic features, typically affects deep soft tissues of the trunk and lower extremities. Rare cases have been reported arising from the viscera and few demonstrating morphology of high-grade dedifferentiation. Here we report a 39-year-old Chinese woman presenting with primary lung LGFMS, which metastasized to the pancreas five years after diagnosis and then relapsed ten years later as a mediastinum mass. Microscopically, the lung and pancreatic lumps shared similar classical features of LGFMS, composed of bland spindle-shaped cells with low mitotic activity...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38492357/endobronchial-solitary-fibrous-tumors-an-enigma-for-diagnosis
#19
Fátima Ramalhosa, Federica Pezzuto, Francesco Fortarezza, Gianluca Canu, Davide Biondini, Eleonora Faccioli, Roberta Polverosi, Chiara Giraudo, Fiorella Calabrese
Solitary fibrous tumors (SFTs) are rare mesenchymal neoplasms constituting less than 2% of all soft tissue tumors. They typically originate in the thoracic cavity, mainly in the pleura, but can also occur in other various sites such as lung parenchyma, pericardium, and bronchus. In this study, a 49-year-old non-smoking female with a history of allergies presented to our pulmonary clinic with a chronic cough. An explorative bronchoscopy revealed an intrabronchial mass in the left superior bronchi, and a 68 Ga-DOTATOC positron emission computed tomography suggested a carcinoid tumor...
March 4, 2024: Pathology, Research and Practice
https://read.qxmd.com/read/38487032/primary-leiomyosarcoma-with-osteosarcomatous-differentiation-of-the-breast
#20
Ekta Sethi, Sunayana Misra, Arvind Ahuja
Primary leiomyosarcoma with osteosarcomatous differentiation of the breast is an uncommon entity. We present the case of a 37-year-old female who presented with a lump in the breast and pulmonary lesions on PET-CT, for which she underwent a toilet mastectomy. Histopathological examination revealed a tumor with cells arranged in sheets. These tumor cells had moderate eosinophilic cytoplasm, highly pleomorphic, irregular hyperchromatic nuclei, coarse chromatin, and prominent nucleoli. Areas with spindle-cell morphology were noted...
2024: Autopsy & Case Reports
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