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[Alexander Lee]

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https://www.readbyqxmd.com/read/28819565/genomic-and-immune-heterogeneity-are-associated-with-differential-responses-to-therapy-in-melanoma
#1
Alexandre Reuben, Christine N Spencer, Peter A Prieto, Vancheswaran Gopalakrishnan, Sangeetha M Reddy, John P Miller, Xizeng Mao, Mariana Petaccia De Macedo, Jiong Chen, Xingzhi Song, Hong Jiang, Pei-Ling Chen, Hannah C Beird, Haven R Garber, Whijae Roh, Khalida Wani, Eveline Chen, Cara Haymaker, Marie-Andrée Forget, Latasha D Little, Curtis Gumbs, Rebecca L Thornton, Courtney W Hudgens, Wei-Shen Chen, Jacob Austin-Breneman, Robert Szczepaniak Sloane, Luigi Nezi, Alexandria P Cogdill, Chantale Bernatchez, Jason Roszik, Patrick Hwu, Scott E Woodman, Lynda Chin, Hussein Tawbi, Michael A Davies, Jeffrey E Gershenwald, Rodabe N Amaria, Isabella C Glitza, Adi Diab, Sapna P Patel, Jianhua Hu, Jeffrey E Lee, Elizabeth A Grimm, Michael T Tetzlaff, Alexander J Lazar, Ignacio I Wistuba, Karen Clise-Dwyer, Brett W Carter, Jianhua Zhang, P Andrew Futreal, Padmanee Sharma, James P Allison, Zachary A Cooper, Jennifer A Wargo
Appreciation for genomic and immune heterogeneity in cancer has grown though the relationship of these factors to treatment response has not been thoroughly elucidated. To better understand this, we studied a large cohort of melanoma patients treated with targeted therapy or immune checkpoint blockade (n = 60). Heterogeneity in therapeutic responses via radiologic assessment was observed in the majority of patients. Synchronous melanoma metastases were analyzed via deep genomic and immune profiling, and revealed substantial genomic and immune heterogeneity in all patients studied, with considerable diversity in T cell frequency, and few shared T cell clones (<8% on average) across the cohort...
2017: NPJ Genomic Medicine
https://www.readbyqxmd.com/read/28815224/a-picture-is-worth-a-thousand-words-electronic-cigarette-content-on-instagram-and-pinterest
#2
Alexander S Lee, Joy L Hart, Clara G Sears, Kandi L Walker, Allison Siu, Courteney Smith
INTRODUCTION: This study examined electronic cigarette (e-cig) content in visual materials posted on the social-media platforms Instagram and Pinterest. Both platforms allow users to upload pictures to the internet and share them globally. Users can search for pictures tagged with specific keywords and phrases. METHODS: Using content analysis, this study identified themes in image postings of e-cigs on social media. During five weeks of data collection, keywords were used to identify pictures related to e-cigs...
July 2017: Tobacco Prevention & Cessation
https://www.readbyqxmd.com/read/28813585/association-of-general-surgery-resident-remediation-and-program-director-attitudes-with-resident-attrition
#3
Alexander C Schwed, Steven L Lee, Edgardo S Salcedo, Mark E Reeves, Kenji Inaba, Richard A Sidwell, Farin Amersi, Chandrakanth Are, Tracey D Arnell, Richard B Damewood, Daniel L Dent, Timothy Donahue, Jeffrey Gauvin, Thomas Hartranft, Garth R Jacobsen, Benjamin T Jarman, Marc L Melcher, John D Mellinger, Jon B Morris, Mark Nehler, Brian R Smith, Mary Wolfe, Amy H Kaji, Christian de Virgilio
Importance: Previous studies of resident attrition have variably included preliminary residents and likely overestimated categorical resident attrition. Whether program director attitudes affect attrition has been unclear. Objectives: To determine whether program director attitudes are associated with resident attrition and to measure the categorical resident attrition rate. Design, Setting, and Participants: This multicenter study surveyed 21 US program directors in general surgery about their opinions regarding resident education and attrition...
August 16, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28811582/a-new-class-of-hybrid-secretion-system-is-employed-in-pseudomonas-amyloid-biogenesis
#4
Sarah L Rouse, William J Hawthorne, Jamie-Lee Berry, Dror S Chorev, Sandra A Ionescu, Sebastian Lambert, Fisentzos Stylianou, Wiebke Ewert, Uma Mackie, R Marc L Morgan, Daniel Otzen, Florian-Alexander Herbst, Per H Nielsen, Morten Dueholm, Hagan Bayley, Carol V Robinson, Stephen Hare, Stephen Matthews
Gram-negative bacteria possess specialised biogenesis machineries that facilitate the export of amyloid subunits for construction of a biofilm matrix. The secretion of bacterial functional amyloid requires a bespoke outer-membrane protein channel through which unfolded amyloid substrates are translocated. Here, we combine X-ray crystallography, native mass spectrometry, single-channel electrical recording, molecular simulations and circular dichroism measurements to provide high-resolution structural insight into the functional amyloid transporter from Pseudomonas, FapF...
August 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/28802073/species-delimitation-with-gene-flow-a-methodological-comparison-and-population-genomics-approach-to-elucidate-cryptic-species-boundaries-in-malaysian-torrent-frogs
#5
Kin Onn Chan, Alana M Alexander, Lee L Grismer, Yong-Chao Su, Jesse L Grismer, Evan S H Quah, Rafe M Brown
Accurately delimiting species boundaries is a non-trivial undertaking that can have significant effects on downstream inferences. We compared the efficacy of commonly-used species delimitation methods (SDMs) and a population genomics approach based on genome-wide single nucleotide polymorphisms (SNPs) to assess lineage separation in the Malaysian Torrent Frog Complex currently recognized as a single species (Amolops larutensis). First, we used morphological, mitochondrial DNA and genome-wide SNPs to identify putative species boundaries by implementing non-coalescent and coalescent-based SDMs (mPTP, iBPP, BFD*)...
August 12, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28799757/immobilization-of-growth-factors-to-collagen-surfaces-using-visible-light
#6
Gabriella Maria Fernandes Cunha, Hyun Jong Lee, Alisha Kumar, Alexander Kreymerman, Sarah Christine Heilshorn, David Myung
In the treatment of traumatic injuries, burns, and ulcers of the eye, inadequate epithelial tissue healing remains a major challenge. Wound healing is a complex process involving the temporal and spatial interplay between cells and their extracellular milieu. It can be impaired by a variety of causes including infection, poor circulation, loss of critical cells and/or proteins, and a deficiency in normal neural signaling (e.g. neurotrophic ulcers). Ocular anatomy is particularly vulnerable to lasting morbidity from delayed healing, whether it be scarring or perforation of the cornea, destruction of the conjunctival mucous membrane, or cicatricial changes to the eyelids and surrounding skin...
August 11, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28797605/space-available-for-cord-motion-and-disc-degeneration-at-the-adjacent-segments-level-of-degenerative-cervical-spondylolisthesis-using-kinematic-mri
#7
Permsak Paholpak, Alexander Nazareth, Kaku Barkoh, Larry V Lee, Joshua Lucas, Zorica Buser, Jeffrey C Wang
The objective was to evaluate motion, disc degeneration and Space Available for Cord (SAC) at the adjacent segments of degenerative cervical spondylolisthesis (DCS) using kinematic Magnetic Resonance Imaging (kMRI). The cervical spine kMRI of sixty-one DCS spinal levels (38 anterolisthesis and 23 retrolisthesis) were analyzed at the listhesis level and its adjacent segments in three position using kMRI. MRAnalyzer3 was used to analyze translation, angular motion and SAC. The caudad level had significantly less translation motion than the listhesis level in overall DCS or grade 2 anterolisthesis group (P<0...
August 7, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28795705/elucidating-the-mechanism-of-mgb2-initial-hydrogenation-via-a-combined-experimental-theoretical-study
#8
Keith G Ray, Leonard E Klebanoff, Jonathan R I Lee, Vitalie Stavila, Tae Wook Heo, Patrick Shea, Alexander A Baker, Shinyoung Kang, Michael Bagge-Hansen, Yi-Sheng Liu, James L White, Brandon C Wood
Mg(BH4)2 is a promising solid-state hydrogen storage material, releasing 14.9 wt% hydrogen upon conversion to MgB2. Although several dehydrogenation pathways have been proposed, the hydrogenation process is less well understood. Here, we present a joint experimental-theoretical study that elucidates the key atomistic mechanisms associated with the initial stages of hydrogen uptake within MgB2. Fourier transform infrared, X-ray absorption, and X-ray emission spectroscopies are integrated with spectroscopic simulations to show that hydrogenation can initially proceed via direct conversion of MgB2 to Mg(BH4)2 complexes...
August 10, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28794084/mechanically-induced-ectopy-via-stretch-activated-cation-nonselective-channels-is-caused-by-local-tissue-deformation-and-results-in-ventricular-fibrillation-if-triggered-on-the-repolarization-wave-edge-commotio-cordis
#9
T Alexander Quinn, Honghua Jin, Peter Lee, Peter Kohl
BACKGROUND: External chest impacts (commotio cordis) can cause mechanically induced premature ventricular excitation (PVEM) and, rarely, ventricular fibrillation (VF). Because block of stretch-sensitive ATP-inactivated potassium channels curtailed VF occurrence in a porcine model of commotio cordis, VF has been suggested to arise from abnormal repolarization caused by stretch activation of potassium channels. Alternatively, VF could result from abnormal excitation by PVEM, overlapping with normal repolarization-related electric heterogeneity...
August 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28793871/diagnostic-accuracy-of-contrast-enhanced-ultrasound-for-characterization-of-kidney-lesions-in-patients-with-and-without-chronic-kidney-disease
#10
Emily Hueywen Chang, Wui Kheong Chong, Sandeep Kumar Kasoji, Julia Rose Fielding, Ersan Altun, Lee B Mullin, Jung In Kim, Jason Peter Fine, Paul Alexander Dayton, Wendy Kimryn Rathmell
BACKGROUND: Patients with chronic kidney disease are at increased risk of cystic kidney disease that requires imaging monitoring in many cases. However, these same patients often have contraindications to contrast-enhanced computed tomography and magnetic resonance imaging. This study evaluates the accuracy of contrast-enhanced ultrasound (CEUS), which is safe for patients with chronic kidney disease, for the characterization of kidney lesions in patients with and without chronic kidney disease...
August 9, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28791874/renal-pelvic-pressure-in-percutaneous-nephrolithotomy-the-effect-of-multiple-tracts
#11
Samuel R Abourbih, Muhannad Alsyouf, Alexander Yeo, Jacob Martin, Janna M Vassantachart, Michael Jung Lee, Jonathan Maldonado, Michelle Lightfoot, Roger Li, Gaudencio Olgin, D Duane Baldwin
INTRODUCTION: During percutaneous nephrolithotomy (PCNL), elevated renal pelvic pressures (RPP) may spread infection through pyelovenous backflow while decreased pressures can hinder visualization and increase bleeding. The purpose of this study was to evaluate the effects of multiple access tracts and different sized endoscopic equipment on RPP in a porcine model. MATERIALS AND METHODS: RPP was measured in 1 versus 2-tract access, rigid versus flexible nephroscopy, and suction versus no suction...
August 9, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28783698/maintenance-of-macrophage-transcriptional-programs-and-intestinal-homeostasis-by-epigenetic-reader-sp140
#12
Stuti Mehta, D Alexander Cronkite, Megha Basavappa, Tahnee L Saunders, Fatemeh Adiliaghdam, Hajera Amatullah, Sara A Morrison, Jose D Pagan, Robert M Anthony, Pierre Tonnerre, Georg M Lauer, James C Lee, Sreehaas Digumarthi, Lorena Pantano, Shannan J Ho Sui, Fei Ji, Ruslan Sadreyev, Chan Zhou, Alan C Mullen, Vinod Kumar, Yang Li, Cisca Wijmenga, Ramnik J Xavier, Terry K Means, Kate L Jeffrey
Epigenetic "readers" that recognize defined posttranslational modifications on histones have become desirable therapeutic targets for cancer and inflammation. SP140 is one such bromodomain- and plant homeodomain (PHD)-containing reader with immune-restricted expression, and single-nucleotide polymorphisms (SNPs) within SP140 associate with Crohn's disease (CD). However, the function of SP140 and the consequences of disease-associated SP140 SNPs have remained unclear. We show that SP140 is critical for transcriptional programs that uphold the macrophage state...
March 3, 2017: Science Immunology
https://www.readbyqxmd.com/read/28767236/bio-instructive-coatings-for-hematopoietic-stem-cell-expansion-based-on-chemical-vapor-deposition-co-polymerization
#13
Anna-Lena Winkler, Meike Koenig, Alexander Welle, Vanessa Trouillet, Domenic Kratzer, Christoph Hussal, Joerg Lahann, Cornelia Lee-Thedieck
We report the chemical vapor deposition (CVD) of dual-functional polymer films for the specific and orthogonal immobilization of two biomolecules (Notch ligand delta-like 1 (DLL1) and an RGD-peptide) that govern the fate of hematopoietic stem and progenitor cells. The composition of the CVD polymer and thus the biomolecule ratio can be tailored to investigate and optimize the influence of the relative surface concentrations of biomolecules on stem cell behavior. Prior to cell experiments, all surfaces were characterized by infrared reflection adsorption spectroscopy, ToF-SIMS, and X-ray photoelectron spectroscopy to confirm the presence of both biomolecules...
August 2, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28767197/the-effect-of-additives-on-the-early-stages-of-growth-of-calcite-single-crystals
#14
Yi-Yeoun Kim, Colin Freeman, Xiuquing Gong, Mark A Levenstein, Yunwei Wang, Alexander Kulak, Clara Anduix Canto, Shunbo Li, Li Chen, Phillip Lee, Hugo K Christenson, Fiona Meldrum
As crystallization processes are often occur rapid, it can be difficult to monitor the growth mechanisms. Here, we use the fact that crystallization proceeds more slowly in small volumes than in bulk solution, to investigate the effects of the soluble additives Mg2+ and poly(styrene sulfonate) on the early stages of growth of calcite crystals. Using a "Crystal Hotel" microfluidic device to provide well-defined, nanoliter volumes, we observe that calcite crystals form via an amorphous precursor phase. Surprisingly, the first calcite crystals formed are perfect rhombohedra, and no morphological influence of the soluble additives is observed until the crystals reach sizes of 0...
August 2, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28758901/stromal-cell-cadherin-11-regulates-adipose-tissue-inflammation-and-diabetes
#15
Sook Kyung Chang, Ayano C Kohlgruber, Fumitaka Mizoguchi, Xavier Michelet, Benjamin J Wolf, Kevin Wei, Pui Y Lee, Lydia Lynch, Danielle Duquette, Victòria Ceperuelo-Mallafré, Alexander S Banks, Michael B Brenner
M2 macrophages, innate lymphoid type 2 cells (ILC2s), eosinophils, Tregs, and invariant NK T cells (iNKT cells) all help to control adipose tissue inflammation, while M1 macrophages, TNF, and other inflammatory cytokines drive inflammation and insulin resistance in obesity. Stromal cells regulate leukocyte responses in lymph nodes, but the role of stromal cells in adipose tissue inflammation is unknown. PDGFRα+ stromal cells are major producers of IL-33 in adipose tissue. Here, we show that mesenchymal cadherin-11 modulates stromal fibroblast function...
July 31, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28758010/skin-cancer-screening-recommendations-for-data-driven-screening-guidelines-and-a-review-of-the-us-preventive-services-task-force-controversy
#16
REVIEW
Mariah M Johnson, Sancy A Leachman, Lisa G Aspinwall, Lee D Cranmer, Clara Curiel-Lewandrowski, Vernon K Sondak, Clara E Stemwedel, Susan M Swetter, John Vetto, Tawnya Bowles, Robert P Dellavalle, Larisa J Geskin, Douglas Grossman, Kenneth F Grossmann, Jason E Hawkes, Joanne M Jeter, Caroline C Kim, John M Kirkwood, Aaron R Mangold, Frank Meyskens, Michael E Ming, Kelly C Nelson, Michael Piepkorn, Brian P Pollack, June K Robinson, Arthur J Sober, Shannon Trotter, Suraj S Venna, Sanjiv Agarwala, Rhoda Alani, Bruce Averbook, Anna Bar, Mirna Becevic, Neil Box, William E Carson, Pamela B Cassidy, Suephy C Chen, Emily Y Chu, Darrel L Ellis, Laura K Ferris, David E Fisher, Kari Kendra, David H Lawson, Philip D Leming, Kim A Margolin, Svetomir Markovic, Mary C Martini, Debbie Miller, Debjani Sahni, William H Sharfman, Jennifer Stein, Alexander J Stratigos, Ahmad Tarhini, Matthew H Taylor, Oliver J Wisco, Michael K Wong
Melanoma is usually apparent on the skin and readily detected by trained medical providers using a routine total body skin examination, yet this malignancy is responsible for the majority of skin cancer-related deaths. Currently, there is no national consensus on skin cancer screening in the USA, but dermatologists and primary care providers are routinely confronted with making the decision about when to recommend total body skin examinations and at what interval. The objectives of this paper are: to propose rational, risk-based, data-driven guidelines commensurate with the US Preventive Services Task Force screening guidelines for other disorders; to compare our proposed guidelines to recommendations made by other national and international organizations; and to review the US Preventive Services Task Force's 2016 Draft Recommendation Statement on skin cancer screening...
March 2017: Melanoma Management
https://www.readbyqxmd.com/read/28753344/scaling-analysis-of-the-screening-length-in-concentrated-electrolytes
#17
Alpha A Lee, Carla S Perez-Martinez, Alexander M Smith, Susan Perkin
The interaction between charged objects in an electrolyte solution is a fundamental question in soft matter physics. It is well known that the electrostatic contribution to the interaction energy decays exponentially with object separation. Recent measurements reveal that, contrary to the conventional wisdom given by the classic Poisson-Boltzmann theory, the decay length increases with the ion concentration for concentrated electrolytes and can be an order of magnitude larger than the ion diameter in ionic liquids...
July 14, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28753319/imaging-of-interlayer-coupling-in-van-der-waals-heterostructures-using-a-bright-field-optical-microscope
#18
Evgeny M Alexeev, Alessandro Catanzaro, Oleksandr Skrypka, Pramoda Kumar Nayak, Seongjoon Ahn, Sangyeon Pak, Juwon Lee, Jung Inn Sohn, Kostya S Novoselov, Hyeon Suk Shin, Alexander I Tartakovskii
Vertically stacked atomic layers from different layered crystals can be held together by van der Waals forces, which can be used for building novel heterostructures, offering a platform for developing a new generation of atomically thin, transparent and flexible devices. The performance of these devices is critically dependent on the layer thickness and the interlayer electronic coupling, influencing the hybridisation of the electronic states as well as charge and energy transfer between the layers. The electronic coupling is affected by the relative orientation of the layers as well as by the cleanliness of their interfaces...
July 28, 2017: Nano Letters
https://www.readbyqxmd.com/read/28746153/a-randomized-controlled-trial-of-postoperative-thoracic-epidural-analgesia-versus-intravenous-patient-controlled-analgesia-after-major-hepatopancreatobiliary-surgery
#19
Thomas A Aloia, Bradford J Kim, Yun Shin Segraves-Chun, Juan P Cata, Mark J Truty, Qiuling Shi, Alexander Holmes, Jose M Soliz, Keyuri U Popat, Thomas F Rahlfs, Jeffrey E Lee, Xin Shelley Wang, Jeffrey S Morris, Vijaya N R Gottumukkala, Jean-Nicolas Vauthey
OBJECTIVES: The primary objective of this randomized trial was to compare thoracic epidural analgesia (TEA) to intravenous patient-controlled analgesia (IV-PCA) for pain control over the first 48 hours after hepatopancreatobiliary (HPB) surgery. Secondary endpoints were patient-reported outcomes, total narcotic utilization, and complications. BACKGROUND: Although adequate postoperative pain control is critical to patient and surgeon success, the optimal analgesia regimen in HPB surgery remains controversial...
September 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28731448/left-frontal-hub-connectivity-during-memory-performance-supports-reserve-in-aging-and-mild-cognitive-impairment
#20
Nicolai Franzmeier, Julia C Hartmann, Alexander Nw Taylor, Migeul A Araque Caballero, Lee Simon-Vermot, Katharina Buerger, Lana M Kambeitz-Ilankovic, Birgit Ertl-Wagner, Claudia Mueller, Cihan Catak, Daniel Janowitz, Robert Stahl, Martin Dichgans, Marco Duering, Michael Ewers
Reserve in aging and Alzheimer's disease (AD) is defined as maintaining cognition at a relatively high level in the presence of neurodegeneration, an ability often associated with higher education among other life factors. Recent evidence suggests that higher resting-state functional connectivity within the frontoparietal control network, specifically the left frontal cortex (LFC) hub, contributes to higher reserve. Following up these previous resting-state fMRI findings, we probed memory-task related functional connectivity of the LFC hub as a neural substrate of reserve...
July 17, 2017: Journal of Alzheimer's Disease: JAD
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