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"Alexander Lee"

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https://www.readbyqxmd.com/read/27736877/no-overt-deficits-in-aged-tau-deficient-c57bl-6-mapttm1-egfp-kit-gfp-knockin-mice
#1
Annika van Hummel, Mian Bi, Stefania Ippati, Julia van der Hoven, Alexander Volkerling, Wei S Lee, Daniel C S Tan, Andre Bongers, Arne Ittner, Yazi D Ke, Lars M Ittner
Several mouse lines with knockout of the tau-encoding MAPT gene have been reported in the past; they received recent attention due to reports that tau reduction prevented Aβ-induced deficits in mouse models of Alzheimer's disease. However, the effects of long-term depletion of tau in vivo remained controversial. Here, we used the tau-deficient GFP knockin line Mapttm1(EGFP)kit on a pure C57Bl/6 background and subjected a large cohort of males and females to a range of motor, memory and behavior tests and imaging analysis, at the advanced age of over 16 months...
2016: PloS One
https://www.readbyqxmd.com/read/27643718/correction-to-dna-compatible-multistep-synthesis-and-applications-to-dna-encoded-libraries
#2
Alexander Lee Satz, Jianping Cai, Yi Chen, Robert Goodnow, Felix Gruber, Agnieszka Kowalczyk, Ann Petersen, Goli Naderi-Oboodi, Lucja Orzechowski, Quentin Strebel
No abstract text is available yet for this article.
September 19, 2016: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/27602776/a-novel-method-for-rna-extraction-from-ffpe-samples-reveals-significant-differences-in-biomarker-expression-between-orthotopic-and-subcutaneous-pancreatic-cancer-patient-derived-xenografts
#3
Malachia Hoover, Yvess Adamian, Mark Brown, Ali Maawy, Alexander Chang, Jacqueline Lee, Armen Gharibi, Matthew H Katz, Jason Fleming, Robert M Hoffman, Michael Bouvet, Robert Doebler, Jonathan A Kelber
Next-generation sequencing (NGS) can identify and validate new biomarkers of cancer onset, progression and therapy resistance. Substantial archives of formalin-fixed, paraffin-embedded (FFPE) cancer samples from patients represent a rich resource for linking molecular signatures to clinical data. However, performing NGS on FFPE samples is limited by poor RNA purification methods. To address this hurdle, we developed an improved methodology for extracting high-quality RNA from FFPE samples. By briefly integrating a newly-designed micro-homogenizing (mH) tool with commercially available FFPE RNA extraction protocols, RNA recovery is increased by approximately 3-fold while maintaining standard A260/A280 ratios and RNA quality index (RQI) values...
September 1, 2016: Oncotarget
https://www.readbyqxmd.com/read/27422356/truncating-mutations-in-app-cause-a-distinct-neurological-phenotype
#4
Steven Klein, Alexander Goldman, Hane Lee, Shahnaz Ghahremani, Viraj Bhakta, Stanley F Nelson, Julian A Martinez-Agosto
Dominant missense mutations in the amyloid β (Aβ) precursor protein (APP) gene have been implicated in early onset Alzheimer disease. These mutations alter protein structure to favor the pathologic production of Aβ. We report that homozygous nonsense mutations in APP are associated with decreased somatic growth, microcephaly, hypotonia, developmental delay, thinning of the corpus callosum, and seizures. We compare the phenotype of this case to those reported in mouse models and demonstrate multiple similarities, strengthening the role of amyloid precursor protein in normal brain function and development...
September 2016: Annals of Neurology
https://www.readbyqxmd.com/read/27418887/endoscopic-versus-open-cubital-tunnel-release-a-systematic-review-and-meta-analysis
#5
REVIEW
Salah Aldekhayel, Alexander Govshievich, James Lee, Youssef Tahiri, Mario Luc
BACKGROUND: Several surgical techniques exist for treatment of cubital tunnel syndrome. Endoscopic cubital tunnel release (ECTuR) has been recently reported as a promising minimally invasive technique. This study aims to compare outcomes and complications of open cubital tunnel release (OCTuR) and ECTuR in the treatment of idiopathic cubital tunnel syndrome. METHODS: A systematic review of the literature (1980-2014) identified 118 citations. Studies including adults with idiopathic cubital tunnel treated exclusively by ECTuR or OCTuR were included...
March 2016: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/27373150/impaired-recall-of-positional-memory-following-chemogenetic-disruption-of-place-field-stability
#6
Rong Zhao, Stacy D Grunke, Madhusudhanan M Keralapurath, Michael J Yetman, Alexander Lam, Tang-Cheng Lee, Konstantinos Sousounis, Yongying Jiang, Deborah A Swing, Lino Tessarollo, Daoyun Ji, Joanna L Jankowsky
The neural network of the temporal lobe is thought to provide a cognitive map of our surroundings. Functional analysis of this network has been hampered by coarse tools that often result in collateral damage to other circuits. We developed a chemogenetic system to temporally control electrical input into the hippocampus. When entorhinal input to the perforant path was acutely silenced, hippocampal firing patterns became destabilized and underwent extensive remapping. We also found that spatial memory acquired prior to neural silencing was impaired by loss of input through the perforant path...
July 19, 2016: Cell Reports
https://www.readbyqxmd.com/read/27343527/calcifying-fibrous-pseudotumor-of%C3%A2-the-posterior-mediastinum-with-encapsulation-of-the-thoracic-duct
#7
Sumudu N Dissanayake, Jeffrey Hagen, Alexander Fedenko, Christopher Lee
We report the first case of calcifying fibrous pseudotumor (CFPT) to arise in the posterior mediastinum with encapsulation of the thoracic duct. This exceedingly rare lesion was incidentally discovered in an asymptomatic young woman and treated with surgical resection, requiring ligation and excision of the thoracic duct. There has been no evidence of tumor recurrence or postoperative complication.
July 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27250484/note-development-of-leg-size-sensors-for-fluid-accumulation-monitoring
#8
Song Zhang, Rajesh Rajamani, Lee Alexander, A Serdar Sezen
A number of diseases can lead to fluid accumulation and swelling in the lower leg. Early detection of leg swelling can be used to effectively predict potential health risks and allows for early intervention from medical providers. Hence this note develops a novel leg size sensor based on the use of magnetic field measurement. An electromagnet is combined with two magnetic field transducers to provide a drift-free leg size estimation technique immune to environmental disturbances. The sensor can measure changes as small as 1 mm in diameter reliably during in vitro tests...
May 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27116029/simulated-screens-of-dna-encoded-libraries-the-potential-influence-of-chemical-synthesis-fidelity-on-interpretation-of-structure-activity-relationships
#9
Alexander L Satz
Simulated screening of DNA encoded libraries indicates that the presence of truncated byproducts complicates the relationship between library member enrichment and equilibrium association constant (these truncates result from incomplete chemical reactions during library synthesis). Further, simulations indicate that some patterns observed in reported experimental data may result from the presence of truncated byproducts in the library mixture and not structure-activity relationships. Potential experimental methods of minimizing the presence of truncates are assessed via simulation; the relationship between enrichment and equilibrium association constant for libraries of differing purities is investigated...
July 11, 2016: ACS Combinatorial Science
https://www.readbyqxmd.com/read/27109596/telemedicine-in-urology-state-of-the-art
#10
REVIEW
Chandy Ellimoottil, Ted Skolarus, Matthew Gettman, Richard Boxer, Alexander Kutikov, Benjamin R Lee, Jeremy Shelton, Todd Morgan
Whereas telemedicine is recognized as one of the fastest-growing components of the healthcare system, the status of telemedicine use in urology is largely unknown. In this narrative review, we detail studies that investigate the use of televisits and teleconsultations for urologic conditions. Moreover, we discuss current regulatory and reimbursement policies. Finally, we discuss the significant barriers to widespread dissemination and implementation of telemedicine and reasons why the field of urology may be positioned to become a leader in the provision of telemedicine services...
August 2016: Urology
https://www.readbyqxmd.com/read/26980057/characterization-of-brain-penetrant-pyrimidine-containing-molecules-with-differential-microtubule-stabilizing-activities-developed-as-potential-therapeutic-agents-for-alzheimer-s-disease-and-related-tauopathies
#11
Jane Kovalevich, Anne-Sophie Cornec, Yuemang Yao, Michael James, Alexander Crowe, Virginia M-Y Lee, John Q Trojanowski, Amos B Smith, Carlo Ballatore, Kurt R Brunden
The microtubule (MT)-stabilizing protein tau disengages from MTs and forms intracellular inclusions known as neurofibrillary tangles in Alzheimer's disease and related tauopathies. Reduced tau binding to MTs in tauopathies may contribute to neuronal dysfunction through decreased MT stabilization and disrupted axonal transport. Thus, the introduction of brain-penetrant MT-stabilizing compounds might normalize MT dynamics and axonal deficits in these disorders. We previously described a number of phenylpyrimidines and triazolopyrimidines (TPDs) that induce tubulin post-translational modifications indicative of MT stabilization...
May 2016: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/26972568/propensity-score-analysis-of-endoscopic-and-open-approaches-to-malignant-paranasal-and-anterior-skull-base-tumor-outcomes
#12
Douglas Farquhar, Luke Kim, Douglas Worrall, Alexander Chiu, John Y K Lee, Sammy Khalili, Sean Grady, Bert W O'Malley, David W Kennedy, Jason G Newman, James N Palmer, Nithin D Adappa
OBJECTIVES/HYPOTHESIS: Malignant sinonasal and skull base tumors are now being resected using an endoscopic technique, but there has been controversy regarding the oncologic safety of this approach. Various studies have compared the outcomes from endoscopic surgery to those from open techniques; however, all have been limited by substantial differences in the patient populations receiving each approach. In this study we compare outcomes of open and endoscopic techniques and use propensity score matching to control for these differences in the patient populations...
August 2016: Laryngoscope
https://www.readbyqxmd.com/read/26891606/anticipatory-nausea-risk-factors-and-its-impact-on-chemotherapy-induced-nausea-and-vomiting-results-from-the-pan-european-emesis-registry-study
#13
Alexander Molassiotis, Paul H Lee, Thomas A Burke, Mario Dicato, Pere Gascon, Fausto Roila, Matti Aapro
CONTEXT: Anticipatory (prechemotherapy) nausea (AN) is a classic conditioned symptom not responding well to current antiemetics. Minimal work has been done to assess its risk factors and impact on chemotherapy-induced nausea and vomiting (CINV). OBJECTIVES: To evaluate risk factors for AN and assess its impact on CINV development. METHODS: We analyzed data (n = 991) from a prospective observational multisite study in eight European countries over three cycles of chemotherapy...
June 2016: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/26847342/serotonin-promotes-exploitation-in-complex-environments-by-accelerating-decision-making
#14
Shachar Iwanir, Adam S Brown, Stanislav Nagy, Dana Najjar, Alexander Kazakov, Kyung Suk Lee, Alon Zaslaver, Erel Levine, David Biron
BACKGROUND: Fast responses can provide a competitive advantage when resources are inhomogeneously distributed. The nematode Caenorhabditis elegans was shown to modulate locomotion on a lawn of bacterial food in serotonin (5-HT)-dependent manners. However, potential roles for serotonergic signaling in responding to food discovery are poorly understood. RESULTS: We found that 5-HT signaling in C. elegans facilitates efficient exploitation in complex environments by mediating a rapid response upon encountering food...
2016: BMC Biology
https://www.readbyqxmd.com/read/26835420/the-influence-of-c-ions-and-x-rays-on-human-umbilical-vein-endothelial-cells
#15
Alexander Helm, Ryonfa Lee, Marco Durante, Sylvia Ritter
Damage to the endothelium of blood vessels, which may occur during radiotherapy, is discussed as a potential precursor to the development of cardiovascular disease. We thus chose human umbilical vein endothelial cells as a model system to examine the effect of low- and high-linear energy transfer (LET) radiation. Cells were exposed to 250 kV X-rays or carbon ions (C-ions) with the energies of either 9.8 MeV/u (LET = 170 keV/μm) or 91 MeV/u (LET = 28 keV/μm). Subculture of cells was performed regularly up to 46 days (~22 population doublings) post-irradiation...
2016: Frontiers in Oncology
https://www.readbyqxmd.com/read/26726589/silicon-surface-modification-using-c4f8-o2-plasma-for-nano-imprint-lithography
#16
Junmyung Lee, Alexander Efremov, Jaemin Lee, Geun Young Yeom, Kwang-Ho Kwon
The investigation of C4F8+O2 feed gas composition on both plasma parameters and plasma treated silicon surface characteristics was carried out. The combination of plasma diagnostics by Langmuir probes and plasma modeling indicated that an increase in O2 mixing ratio results in monotonically decreasing densities of CF(x) (x = 1-3) radicals as well as in non-monotonic behavior of F atom density. The surface characterization by X-ray photoelectron spectroscopy and contact angle measurements showed that the C4F8+O2 mixtures with less than 60% 02 result in modification of Si surfaces due to the deposition of the FC polymer films while the change of O2 mixing ratio in the range of 30%-60% provides an effective adjustment of the surface characteristics such as surface energy, contact angle, etc...
November 2015: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/26448909/impaired-target-detection-in-schizophrenia-and-the-ventral-attentional-network-findings-from-a-joint-event-related-potential-functional-mri-analysis
#17
Jonathan K Wynn, Amy M Jimenez, Brian J Roach, Alexander Korb, Junghee Lee, William P Horan, Judith M Ford, Michael F Green
Schizophrenia patients have abnormal neural responses to salient, infrequent events. We integrated event-related potentials (ERP) and fMRI to examine the contributions of the ventral (salience) and dorsal (sustained) attention networks to this dysfunctional neural activation. Twenty-one schizophrenia patients and 22 healthy controls were assessed in separate sessions with ERP and fMRI during a visual oddball task. Visual P100, N100, and P300 ERP waveforms and fMRI activation were assessed. A joint independent components analysis (jICA) on the ERP and fMRI data were conducted...
2015: NeuroImage: Clinical
https://www.readbyqxmd.com/read/26390919/tumor-suppressor-wwox-moderates-the-mitochondrial-respiratory-complex
#18
Amanda Choo, Louise V O'Keefe, Cheng Shoou Lee, Stephen L Gregory, Zeeshan Shaukat, Alexander Colella, Kristie Lee, Donna Denton, Robert I Richards
Fragile site FRA16D exhibits DNA instability in cancer, resulting in diminished levels of protein from the WWOX gene that spans it. WWOX suppresses tumor growth by an undefined mechanism. WWOX participates in pathways involving aerobic metabolism and reactive oxygen species. WWOX comprises two WW domains as well as a short-chain dehydrogenase/reductase enzyme. Herein is described an in vivo genetic analysis in Drosophila melanogaster to identify functional interactions between WWOX and metabolic pathways. Altered WWOX levels modulate variable cellular outgrowths caused by genetic deficiencies of components of the mitochondrial respiratory complexes...
December 2015: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/26230778/concentrating-tripartite-quantum-information
#19
Alexander Streltsov, Soojoon Lee, Gerardo Adesso
We introduce the concentrated information of tripartite quantum states. For three parties Alice, Bob, and Charlie, it is defined as the maximal mutual information achievable between Alice and Charlie via local operations and classical communication performed by Charlie and Bob. We derive upper and lower bounds to the concentrated information, and obtain a closed expression for it on several classes of states including arbitrary pure tripartite states in the asymptotic setting. We show that distillable entanglement, entanglement of assistance, and quantum discord can all be expressed in terms of the concentrated information, thus revealing its role as a unifying informational primitive...
July 17, 2015: Physical Review Letters
https://www.readbyqxmd.com/read/26176408/dna-encoded-library-selections-and-insights-provided-by-computational-simulations
#20
Alexander L Satz
DNA encoded library (DEL) technology allows for rapid generation of extremely large numbers of small molecules and is often used to find novel chemical starting points for pharmaceutically relevant proteins. DEL selection output consists of a list of small-molecule structures and enrichment levels. It is widely presumed that molecules with greater enrichment will have larger equilibrium association constants, and follow-up efforts are triaged accordingly. Herein we describe a simple mathematical model used to simulate DEL selections...
October 16, 2015: ACS Chemical Biology
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