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https://www.readbyqxmd.com/read/29781944/early-comparative-outcomes-of-carbon-fiber-reinforced-polymer-plate-in-the-fixation-of-distal-femur-fractures
#1
Phillip M Mitchell, Adam K Lee, Cory A Collinge, Bruce H Ziran, Kate G Hartley, A Alex Jahangir
OBJECTIVE: To evaluate the early clinical results of distal femur fractures treated with carbon fiber reinforced - polyetheretherketone (CFR-PEEK) plates compared to stainless steel (SS) lateral locking plates. DESIGN: Retrospective comparative cohort study SETTING:: ACS Level I trauma center. PATIENTS/PARTICIPANTS: Twenty-two patients (11 SS, 11 CFR-PEEK) with closed distal femur fractures treated by a single surgeon over a 6-year period...
May 16, 2018: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29777787/patency-and-incontinence-rates-after-robotic-bladder-neck-reconstruction-for-vesicourethral-anastomotic-stenosis-and-recalcitrant-bladder-neck-contractures-the-turns-experience
#2
Eric J Kirshenbaum, Lee C Zhao, Jeremy B Myers, Sean P Elliott, Alex J Vanni, Nima Baradaran, Bradley A Erickson, Jill C Buckley, Bryan B Voelzke, Michael A Granieri, Stephen J Summers, Benjamin N Breyer, Atreya Dash, Aaron Weinberg, Nejd F Alsikafi
OBJECTIVE: To review a robotic approach to recalcitrant bladder neck obstruction and assess success and incontinence rates. METHODS: Patients with a recalcitrant bladder neck contracture or vesicourethral anastomotic stenosis who underwent robotic bladder neck reconstruction (RBNR) were identified. We reviewed patient demographics, medical history, etiology, previous endoscopic management, cystoscopic and symptomatic outcomes, urinary continence and complications...
May 16, 2018: Urology
https://www.readbyqxmd.com/read/29776585/tears-of-wine-the-dance-of-the-droplets
#3
REVIEW
Alex Nikolov, Darsh Wasan, Jongju Lee
For a long time, the phenomenon known as the "tears of wine" was believed to be due only to the surface tension gradient (e.g., the Thomson-Marangoni stress on the fluid/fluid surface's dynamics of wetting) and gravity. We experimentally demonstrated that the wine tear formation is not solely due to the surface tension gradient; instead, the ridge instability triggers the wine tears. Pouring wine into a glass causes a wine film to form on the glass. The film drains down under gravity and a ridge forms at its upper part...
May 5, 2018: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/29775536/spatial-variability-of-sources-and-mixing-state-of-atmospheric-particles-in-a-metropolitan-area
#4
Qing Ye, Peishi Gu, Hugh Z Li, Ellis S Robinson, Eric M Lipsky, Christos Kaltsonoudis, Alex K Y Lee, Joshua Schulz Apte, Allen L Robinson, Ryan Christopher Sullivan, Albert A Presto, Neil M Donahue
Characterizing intra-city variations of atmospheric particulate matter has mostly relied on fixed-site monitoring and quantifying variability in terms of different bulk aerosol species. In this study, we performed ground-based mobile measurements using a single-particle mass spectrometer to study spatial patterns of source-specific particles and the evolution of particle mixing state in 21 areas in the metropolitan area of Pittsburgh, PA. We selected sampling areas based on traffic density and restaurant density with each area ranging from 0...
May 18, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29764965/effect-of-treat-to-target-strategies-aiming-at-remission-of-arterial-stiffness-in-early-rheumatoid-arthritis-a-randomized-controlled-study
#5
Lydia Ho-Pui Tam, Qing Shang, Edmund Kwok-Ming Li, Priscilla Ching-Han Wong, Kitty Yan Kwok, Emily Wai-Lin Kun, Isaac Cheuk-Wan Yim, Violet Ka-Lai Lee, Ronald Man-Lung Yip, Steve Hin-Ting Pang, Virginia Weng-Nga Lao, Queenie Wah-Yan Mak, Isaac Tsz-Ho Cheng, Xerox Sze-Lok Lau, Tena Ka-Yan Li, Tracy Yaner Zhu, Alex Pui-Wai Lee, Lai-Shan Tam
OBJECTIVE: To determine the efficacy of 2 tight control treatment strategies aiming at Simplified Disease Activity Score (SDAI) remission (SDAI ≤ 3.3) compared to 28-joint count Disease Activity Score (DAS28) remission (DAS28 < 2.6) in the prevention of arterial stiffness in patients with early rheumatoid arthritis (RA). METHODS: This was an open-label study in which 120 patients with early RA were randomized to receive 1 year of tight control treatment. Group 1 (n = 60) aimed to achieve SDAI ≤ 3...
May 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29757973/a-new-strategy-to-control-and-eradicate-undruggable-oncogenic-k-ras-driven-pancreatic-cancer-molecular-insights-and-core-principles-learned-from-developmental-and-evolutionary-biology
#6
REVIEW
Robert E Van Sciver, Michael P Lee, Caroline Dasom Lee, Alex C Lafever, Elizaveta Svyatova, Kevin Kanda, Amber L Colliver, Lauren L Siewertsz van Reesema, Angela M Tang-Tan, Vasilena Zheleva, Monicah N Bwayi, Minglei Bian, Rebecca L Schmidt, Lynn M Matrisian, Gloria M Petersen, Amy H Tang
Oncogenic K-RAS mutations are found in virtually all pancreatic cancers, making K-RAS one of the most targeted oncoproteins for drug development in cancer therapies. Despite intense research efforts over the past three decades, oncogenic K-RAS has remained largely "undruggable". Rather than targeting an upstream component of the RAS signaling pathway (i.e., EGFR/HER2) and/or the midstream effector kinases (i.e., RAF/MEK/ERK/PI3K/mTOR), we propose an alternative strategy to control oncogenic K-RAS signal by targeting its most downstream signaling module, Seven-In-Absentia Homolog (SIAH)...
May 14, 2018: Cancers
https://www.readbyqxmd.com/read/29750786/correction-single-trait-and-multi-trait-genome-wide-association-analyses-identify-novel-loci-for-blood-pressure-in-african-ancestry-populations
#7
Jingjing Liang, Thu H Le, Digna R Velez Edwards, Bamidele O Tayo, Kyle J Gaulton, Jennifer A Smith, Yingchang Lu, Richard A Jensen, Guanjie Chen, Lisa R Yanek, Karen Schwander, Salman M Tajuddin, Tamar Sofer, Wonji Kim, James Kayima, Colin A McKenzie, Ervin Fox, Michael A Nalls, J Hunter Young, Yan V Sun, Jacqueline M Lane, Sylvia Cechova, Jie Zhou, Hua Tang, Myriam Fornage, Solomon K Musani, Heming Wang, Juyoung Lee, Adebowale Adeyemo, Albert W Dreisbach, Terrence Forrester, Pei-Lun Chu, Anne Cappola, Michele K Evans, Alanna C Morrison, Lisa W Martin, Kerri L Wiggins, Qin Hui, Wei Zhao, Rebecca D Jackson, Erin B Ware, Jessica D Faul, Alex P Reiner, Michael Bray, Joshua C Denny, Thomas H Mosley, Walter Palmas, Xiuqing Guo, George J Papanicolaou, Alan D Penman, Joseph F Polak, Kenneth Rice, Ken D Taylor, Eric Boerwinkle, Erwin P Bottinger, Kiang Liu, Neil Risch, Steven C Hunt, Charles Kooperberg, Alan B Zonderman, Cathy C Laurie, Diane M Becker, Jianwen Cai, Ruth J F Loos, Bruce M Psaty, David R Weir, Sharon L R Kardia, Donna K Arnett, Sungho Won, Todd L Edwards, Susan Redline, Richard S Cooper, D C Rao, Jerome I Rotter, Charles Rotimi, Daniel Levy, Aravinda Chakravarti, Xiaofeng Zhu, Nora Franceschini
[This corrects the article DOI: 10.1371/journal.pgen.1006728.].
May 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29740330/heart-failure-and-frailty-in-the-community-living-elderly-population-what-the-ufo-study-will-tell-us
#8
Erik Fung, Elsie Hui, Xiaobo Yang, Leong T Lui, King F Cheng, Qi Li, Yiting Fan, Daljit S Sahota, Bosco H M Ma, Jenny S W Lee, Alex P W Lee, Jean Woo
Heart failure and frailty are clinical syndromes that present with overlapping phenotypic characteristics. Importantly, their co-presence is associated with increased mortality and morbidity. While mechanical and electrical device therapies for heart failure are vital for select patients with advanced stage disease, the majority of patients and especially those with undiagnosed heart failure would benefit from early disease detection and prompt initiation of guideline-directed medical therapies. In this article, we review the problematic interactions between heart failure and frailty, introduce a focused cardiac screening program for community-living elderly initiated by a mobile communication device app leading to the Undiagnosed heart Failure in frail Older individuals (UFO) study, and discuss how the knowledge of pre-frailty and frailty status could be exploited for the detection of previously undiagnosed heart failure or advanced cardiac disease...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29739475/an-outbreak-of-streptococcus-pyogenes-in-a-mental-health-facility-advantage-of-well-timed-whole-genome-sequencing-over-emm-typing
#9
Sarah M Bergin, Balamurugan Periaswamy, Timothy Barkham, Hong Choon Chua, Yee Ming Mok, Daniel Shuen Sheng Fung, Alex Hsin Chuan Su, Yen Ling Lee, Ming Lai Ivan Chua, Poh Yong Ng, Wei Jia Wendy Soon, Collins Wenhan Chu, Siyun Lucinda Tan, Mary Meehan, Brenda Sze Peng Ang, Yee Sin Leo, Matthew T G Holden, Partha De, Li Yang Hsu, Swaine L Chen, Paola Florez de Sessions, Kalisvar Marimuthu
OBJECTIVEWe report the utility of whole-genome sequencing (WGS) conducted in a clinically relevant time frame (ie, sufficient for guiding management decision), in managing a Streptococcus pyogenes outbreak, and present a comparison of its performance with emm typing.SETTINGA 2,000-bed tertiary-care psychiatric hospital.METHODSActive surveillance was conducted to identify new cases of S. pyogenes. WGS guided targeted epidemiological investigations, and infection control measures were implemented. Single-nucleotide polymorphism (SNP)-based genome phylogeny, emm typing, and multilocus sequence typing (MLST) were performed...
May 9, 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29737830/self-healing-wide-and-thin-li-metal-anodes-prepared-using-calendared-li-metal-powder-for-improving-cycle-life-and-rate-capability
#10
Dahee Jin, Jeonghun Oh, Alex Friesen, Kyuman Kim, Taejin Jo, Yong Min Lee, Myung-Hyun Ryou
The commercialization of Li metal electrodes is a long-standing objective in the battery community. To accomplish this goal, the formation of Li dendrites and mossy Li deposition, which cause poor cycle performance and safety issues, must be resolved. In addition, it is necessary to develop wide and thin Li metal anodes to increase not only the energy density, but also the design freedom of large-scale Li-metal-based batteries. We solved both issues by developing a novel approach involving the application of calendared stabilized Li metal powder (LiMP) electrodes as anodes...
May 8, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29729303/intestinal-microbial-derived-sphingolipids-are-inversely-associated-with-childhood-food-allergy
#11
Kathleen Lee-Sarwar, Rachel S Kelly, Jessica Lasky-Su, D Branch Moody, Alex R Mola, Tan-Yun Cheng, Laurie E Comstock, Robert S Zeiger, George T O'Connor, Megan T Sandel, Leonard B Bacharier, Avraham Beigelman, Nancy Laranjo, Diane R Gold, Supinda Bunyavanich, Jessica H Savage, Scott T Weiss, Patrick J Brennan, Augusto A Litonjua
Intestinal Bacteroides-derived sphingolipids in infancy were inversely associated with food allergy among sensitized subjects. This may be mediated in part by invariant NK T cell activation.
May 2, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29704269/genotype-guided-warfarin-dosing-versus-conventional-dosing-strategies-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#12
Gary Tse, Mengqi Gong, Guangping Li, Sunny Hei Wong, William K K Wu, Wing Tak Wong, Leonardo Roever, Alex Pui Wai Lee, Gregory Y H Lip, Martin C S Wong, Tong Liu
BACKGROUND: Previous trials on the effectiveness of genotype-guided warfarin dosing versus conventional dosing have been inconclusive. We conducted a systematic review and meta-analysis of randomized trials comparing genotype-guided to conventional dosing strategies. METHODS: PubMed and Cochrane Library were searched until 23rd October 2017. RESULTS: A total of 76 and 94 entries were retrieved. A total of 2626 subjects in the genotype-guided dosing (mean age: 63...
April 28, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29685872/comparative-effectiveness-of-a-technology-facilitated-depression-care-management-model-in-safety-net-primary-care-patients-with-type-2-diabetes-6-month-outcomes-of-a-large-clinical-trial
#13
Shinyi Wu, Kathleen Ell, Haomiao Jin, Irene Vidyanti, Chih-Ping Chou, Pey-Jiuan Lee, Sandra Gross-Schulman, Laura Myerchin Sklaroff, David Belson, Arthur M Nezu, Joel Hay, Chien-Ju Wang, Geoffrey Scheib, Paul Di Capua, Caitlin Hawkins, Pai Liu, Magaly Ramirez, Brian W Wu, Mark Richman, Caitlin Myers, Davin Agustines, Robert Dasher, Alex Kopelowicz, Joseph Allevato, Mike Roybal, Eli Ipp, Uzma Haider, Sharon Graham, Vahid Mahabadi, Jeffrey Guterman
BACKGROUND: Comorbid depression is a significant challenge for safety-net primary care systems. Team-based collaborative depression care is effective, but complex system factors in safety-net organizations impede adoption and result in persistent disparities in outcomes. Diabetes-Depression Care-management Adoption Trial (DCAT) evaluated whether depression care could be significantly improved by harnessing information and communication technologies to automate routine screening and monitoring of patient symptoms and treatment adherence and allow timely communication with providers...
April 23, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29683667/optimization-of-selective-mitogen-activated-protein-kinase-interacting-kinases-1-and-2-mnk1-2-inhibitors-for-the-treatment-of-blast-crisis-leukemia
#14
Hai Yan Yang, Lohitha Rao Chennamaneni, Melvyn Wai Tuck Ho, Shi Hua Ang, Eldwin Sum Wai Tan, Duraiswamy Athisayamani Jeyaraj, Yoon Sheng Yeap, Boping Liu, Esther Hq Ong, Joma Kanikadu Joy, John Liang Kuan Wee, Perlyn Kwek, Priya Retna, Nurul Dinie, Thuy Thi Hanh Nguyen, Shi Jing Tai, Vithya Manoharan, Vishal Pendharkar, Choon Bing Low, Yun Shan Chew, Susmitha Vuddagiri, Kanda Sangthongpitag, Meng Ling Choong, May Ann Lee, Srinivasaraghavan Kannan, Chandra S Verma, Anders Poulsen, Sharon Lim, Charles Chuah, Tiong Sin Ong, Jeffrey Hill, Alex Matter, Kassoum Nacro
Chronic Myeloid Leukemia (CML) is a myeloproliferative disease caused by bcr-abl1, a constitutively active tyrosine kinase fusion gene responsible for an abnormal proliferation of leukemic stem cells (LSCs). Inhibition of BCR-ABL1 kinase activity offers long term relief to CML patients. However, for a proportion of them, BCR-ABL1 inhibition will become ineffective at treating the disease and CML will progress to blast crisis (BC) CML with poor prognosis. BC-CML is often associated with excessive phosphorylated eukaryotic translation initiation factor 4E (eIF4E) which renders LSCs capable of proliferating via self-renewal, oblivious to BCR-ABL1 inhibition...
April 23, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29682598/cycloid-scanning-for-wide-field-optical-coherence-tomography-endomicroscopy-and-angiography-in-vivo
#15
Kaicheng Liang, Zhao Wang, Osman O Ahsen, Hsiang-Chieh Lee, Benjamin M Potsaid, Vijaysekhar Jayaraman, Alex Cable, Hiroshi Mashimo, Xingde Li, James G Fujimoto
Devices that perform wide field-of-view (FOV) precision optical scanning are important for endoscopic assessment and diagnosis of luminal organ disease such as in gastroenterology. Optical scanning for in vivo endoscopic imaging has traditionally relied on one or more proximal mechanical actuators, limiting scan accuracy and imaging speed. There is a need for rapid and precise two-dimensional (2D) microscanning technologies to enable the translation of benchtop scanning microscopies to in vivo endoscopic imaging...
January 20, 2018: Optica
https://www.readbyqxmd.com/read/29682008/transcatheter-tricuspid-valve-edge-to-edge-repair-for-severe-tricuspid-regurgitation-in-a-chinese-patient
#16
Gary S H Cheung, Kevin K H Kam, Yat-Yin Lam, Alex P W Lee
No abstract text is available yet for this article.
2018: Heart Asia
https://www.readbyqxmd.com/read/29677092/current-publication-rates-of-abstracts-presented-at-the-orthopaedic-trauma-association-annual-meetings-2005-2010
#17
Ryan Lee, Ishwarya S Mamidi, Alex Gu, Jordan S Cohen, William Probasco, James DeBritz
OBJECTIVES: To evaluate the publication rate of abstracts presented at the 2005-2010 Orthopaedic Trauma Association (OTA) Annual Meetings. METHODS: All abstracts from the 2005 to 2010 OTA meetings were identified through the OTA's official website. Each abstract was searched across PubMed and Google to determine its publication status. The overall publication rate of abstracts was determined, along with the first authors' sex, number of authors, time and journal of publication, and analyzed with statistical testing...
May 2018: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29672134/metabolism-and-biodegradation-of-spacecraft-cleaning-reagents-by-strains-of-spacecraft-associated-acinetobacter
#18
Rakesh Mogul, Gregory A Barding, Sidharth Lalla, Sooji Lee, Steve Madrid, Ryan Baki, Mahjabeen Ahmed, Hania Brasali, Ivonne Cepeda, Trevor Gornick, Shawn Gunadi, Nicole Hearn, Chirag Jain, Eun Jin Kim, Thi Nguyen, Vinh Bao Nguyen, Alex Oei, Nicole Perkins, Joseph Rodriguez, Veronica Rodriguez, Gautam Savla, Megan Schmitz, Nicholas Tedjakesuma, Jillian Walker
Spacecraft assembly facilities are oligotrophic and low-humidity environments, which are routinely cleaned using alcohol wipes for benchtops and spacecraft materials, and alkaline detergents for floors. Despite these cleaning protocols, spacecraft assembly facilities possess a persistent, diverse, dynamic, and low abundant core microbiome, where the Acinetobacter are among the dominant members of the community. In this report, we show that several spacecraft-associated Acinetobacter metabolize or biodegrade the spacecraft cleaning reagents of ethanol (ethyl alcohol), 2-propanol (isopropyl alcohol), and Kleenol 30 (floor detergent) under ultraminimal conditions...
April 19, 2018: Astrobiology
https://www.readbyqxmd.com/read/29664228/measure-the-unmeasurable-by-ir-spectroscopy-carbon-deposition-kinetics-in-dry-reforming-of-methane
#19
Jiazheng Ren, Alex Chinghuan Lee, Kai Cheng, Ming Li, Yongsheng Chen
Dry reforming of methane converts two greenhouse gases to syngas, and Ni catalysts are commonly used for this reaction. A major catalyst deactivation mechanism is carbon deposition. Although numerous kinetic modelling works have been done on carbon formation, there were only scarce attempts to measure carbon deposition kinetics under relevant (but not real) conditions due to technical difficulties. Here we report first successful measurements of the kinetics under real reaction conditions. This was made possible by a novel algorithm we have developed...
April 17, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/29618797/development-of-a-characterised-tool-kit-for-the-interrogation-of-nlrp3-inflammasome-dependent-responses
#20
Elena Redondo-Castro, Dorte Faust, Simon Fox, Alex G Baldwin, Simon Osborne, Michael J Haley, Eric Karran, Hugh Nuthall, Peter J Atkinson, Lee A Dawson, Carol Routledge, Stuart M Allan, Sally Freeman, Janet Brownlees, David Brough
Inflammation is an established contributor to disease and the NLRP3 inflammasome is emerging as a potential therapeutic target. A number of small molecule inhibitors of the NLRP3 pathway have been described. Here we analysed the most promising of these inhibitor classes side by side to assess relative potency and selectivity for their respective putative targets. Assessed using ASC inflammasome-speck formation, and release of IL-1β, in both human monocyte/macrophage THP1 cells and in primary mouse microglia, we compared the relative potency and selectivity of P2X7 inhibitors, inflammasome inhibitors (diarylsulfonylurea vs...
April 4, 2018: Scientific Reports
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