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https://www.readbyqxmd.com/read/28910621/a-fully-automated-approach-to-spike-sorting
#1
Jason E Chung, Jeremy F Magland, Alex H Barnett, Vanessa M Tolosa, Angela C Tooker, Kye Y Lee, Kedar G Shah, Sarah H Felix, Loren M Frank, Leslie F Greengard
Understanding the detailed dynamics of neuronal networks will require the simultaneous measurement of spike trains from hundreds of neurons (or more). Currently, approaches to extracting spike times and labels from raw data are time consuming, lack standardization, and involve manual intervention, making it difficult to maintain data provenance and assess the quality of scientific results. Here, we describe an automated clustering approach and associated software package that addresses these problems and provides novel cluster quality metrics...
September 13, 2017: Neuron
https://www.readbyqxmd.com/read/28899363/a-phase-i-open-label-dose-escalation-study-of-the-anti-her3-monoclonal-antibody-ljm716-in-patients-with-advanced-squamous-cell-carcinoma-of-the-esophagus-or-head-and-neck-and-her2-overexpressing-breast-or-gastric-cancer
#2
Kerry Lynn Reynolds, Philippe L Bedard, Se-Hoon Lee, Chia-Chi Lin, Josep Tabernero, Maria Alsina, Ezra Cohen, José Baselga, George Blumenschein, Donna M Graham, Ignacio Garrido-Laguna, Dejan Juric, Sunil Sharma, Ravi Salgia, Abdelkader Seroutou, Xianbin Tian, Rose Fernandez, Alex Morozov, Qing Sheng, Thiruvamoor Ramkumar, Angela Zubel, Yung-Jue Bang
BACKGROUND: Human epidermal growth factor receptor 3 (HER3) is important in maintaining epidermal growth factor receptor-driven cancers and mediating resistance to targeted therapy. A phase I study of anti-HER3 monoclonal antibody LJM716 was conducted with the primary objective to identify the maximum tolerated dose (MTD) and/or recommended dose for expansion (RDE), and dosing schedule. Secondary objectives were to characterize safety/tolerability, pharmacokinetics, pharmacodynamics, and preliminary antitumor activity...
September 12, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28893450/emergency-medicine-evaluation-and-management-of-the-end-stage-renal-disease-patient
#3
REVIEW
Brit Long, Alex Koyfman, Courtney M Lee
BACKGROUND: End stage renal disease (ESRD) is increasing in the U.S., and these patients demonstrate greater all-cause mortality, cardiovascular events, and hospitalization rates when compared to those with normal renal function. These patients may experience significant complications associated with loss of renal function and dialysis. OBJECTIVE: This review evaluates complications of ESRD including cardiopulmonary, neurologic, infectious disease, vascular, and access site complications, as well as medication use in this population...
September 5, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28891100/roq1-mediates-recognition-of-the-xanthomonas-and-pseudomonas-effector-proteins-xopq-and-hopq1
#4
Alex Schultink, Tiancong Qi, Arielle Lee, Adam D Steinbrenner, Brian Staskawicz
Xanthomonas spp are phytopathogenic bacteria that can cause disease on a wide variety of plant species resulting in significant impacts on crop yields. Limited genetic resistance is available in most crop species and current control methods are often inadequate, particularly when environmental conditions favor disease. The plant Nicotiana benthamiana has been shown to be resistant to Xanthomonas and Pseudomonas due to an immune response triggered by the bacterial effector proteins XopQ and HopQ1, respectively...
September 11, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28864465/automated-left-heart-chambers-volumetric-assessment-using-three-dimensional-echocardiography-in-chinese-adolescents
#5
Xiu-Xia Luo, Fang Fang, Hung-Kwan So, Chao Liu, Man-Ching Yam, Alex Pui-Wai Lee
BACKGROUND: Several studies have reported the accuracy and reproducibility of HeartModel for automated determination of three-dimensional echocardiography (3DE)-derived left heart volumes and left ventricular (LV) ejection fraction (LVEF) in adult patients. However, it remains unclear whether this automated adaptive analytics algorithm, derived from a 'training' population, can encompass adequate echo images in Chinese adolescents. OBJECTIVES: The aim of our study was to explore the accuracy of HeartModel in adolescents compared with expert manual three-dimensional (3D) echocardiography...
September 1, 2017: Echo Research and Practice
https://www.readbyqxmd.com/read/28855115/catheter-ablation-versus-medical-rate-control-in-atrial-fibrillation-and-systolic-dysfunction-camera-mri
#6
Sandeep Prabhu, Andrew J Taylor, Ben T Costello, David M Kaye, Alex Aj McLellan, Aleksandr Voskoboinik, Hariharan Sugumar, Siobhan M Lockwood, Michael B Stokes, Bhupesh Pathik, Chrishan J Nalliah, Geoff R Wong, Sonia M Azzopardi, Sarah Gutman, Geoffrey Lee, Jamie Layland, Justin A Mariani, Liang-Han Ling, Jonathan M Kalman, Peter M Kistler
BACKGROUND: Atrial fibrillation (AF) and left ventricular systolic dysfunction (LVSD) frequently co-exist despite adequate rate-control. Existing randomized studies of AF and LVSD of varying etiologies have demonstrated modest benefits with a rhythm control strategy. OBJECTIVE: To determine whether catheter ablation (CA) for AF could improve LVSD compared to medical rate-control (MRC) where the etiology of the LVSD was unexplained, apart from the presence of AF...
August 22, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28828076/effects-of-cluster-sets-and-rest-redistribution-on-mechanical-responses-to-back-squats-in-trained-men
#7
James J Tufano, Jenny A Conlon, Sophia Nimphius, Lee E Brown, Alex Petkovic, Justin Frick, G Gregory Haff
Eight resistance-trained men completed three protocols separated by 48-96 hours. Each protocol included 36 repetitions with the same rest duration, but the frequency and length of rest periods differed. The cluster sets of four (CS4) protocol included 30 s of rest after the 4th, 8th, 16th, 20th, 28th, and 32nd repetition in addition to 120 s of rest after the 12th and 24th repetition. For the other two protocols, the total 420 s rest time of CS4 was redistributed to include nine sets of four repetitions (RR4) with 52...
September 2017: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28813531/short-term-leprosy-forecasting-from-an-expert-opinion-survey
#8
Michael S Deiner, Lee Worden, Alex Rittel, Sarah F Ackley, Fengchen Liu, Laura Blum, James C Scott, Thomas M Lietman, Travis C Porco
We conducted an expert survey of leprosy (Hansen's Disease) and neglected tropical disease experts in February 2016. Experts were asked to forecast the next year of reported cases for the world, for the top three countries, and for selected states and territories of India. A total of 103 respondents answered at least one forecasting question. We elicited lower and upper confidence bounds. Comparing these results to regression and exponential smoothing, we found no evidence that any forecasting method outperformed the others...
2017: PloS One
https://www.readbyqxmd.com/read/28807347/dorsoradial-instability-of-the-thumb-metacarpophalangeal-joint-a-biomechanical-investigation
#9
Byung-Sung Kim, Alex Doermann, Michelle McGarry, Masaki Akeda, Hansel Ihn, Thay Q Lee
PURPOSE: To define the role of the dorsal capsule and associated dorsal fibrocartilage (DFC) and their interactions with the radial collateral ligament (RCL) as a thumb metacarpophalangeal (MCP) joint stabilizer. METHODS: Eight cadaveric thumbs were mounted onto a custom jig with 20 N of muscle load applied. The thumb position in space was digitized to measure ulnar-radial, pronation-supination, and volar-dorsal laxity at 0°, 30°, and 60° MCP joint flexion. Serial sectioning was performed and measurements were repeated for the intact state, proper RCL insufficiency, proper and accessory (complete) RCL insufficiency, complete RCL with 50% DFC (radial) insufficiency, and complete RCL with complete DFC insufficiency...
August 11, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28802148/inattentional-blindness-in-anesthesiology-a-simulation-study
#10
Anthony M-H Ho, Joseph Y C Leung, Glenio B Mizubuti, Leeanne H Contardi, Matthew T V Chan, Thomas S F Lo, Alex K T Lee
STUDY OBJECTIVES: Inattentional blindness is the psychological phenomenon of inability to see the unexpected even if it is in plain view. We hypothesized that anesthesiologists may overlook unexpected intraoperative events whereas medical students, lacking in intraoperative monitoring experience and knowledge, may be more likely to notice such events. DESIGN: A simulation study using a video of a simulated septic patient undergoing abdominal surgery. SETTING: A large academic center...
August 9, 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28798083/hamp1-mrna-and-plasma-hepcidin-levels-are-influenced-by-sex-and-strain-but-don-t-predict-tissue-iron-levels-in-inbred-mice
#11
Stela McLachlan, Kathryn E Page, Seung-Min Lee, Alex Loguinov, Erika Valore, Simon T Hui, Grace Jung, Jie Zhou, Aldons J Lusis, Brie Fuqua, Tomas Ganz, Elizabeta Nemeth, Chris D Vulpe
Iron homeostasis is tightly regulated and the peptide hormone hepcidin is considered to be a principal regulator of iron metabolism. Previous studies in a limited number of mouse strains found equivocal sex and strain dependent differences in mRNA and serum levels of hepcidin. Similarly, conflicting data on the relationship between hepcidin (Hamp1) mRNA levels and iron status as assessed by transferrin saturation and tissue iron concentrations were reported. Our aim was to clarify the relationships between strain, sex and hepcidin expression by examining multiple tissues and the effects of different dietary conditions in multiple inbred strains...
August 10, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28789959/emergency-department-blood-alcohol-level-associates-with-injury-factors-and-six-month-outcome-after-uncomplicated-mild-traumatic-brain-injury
#12
John K Yue, Laura B Ngwenya, Pavan S Upadhyayula, Hansen Deng, Ethan A Winkler, John F Burke, Young M Lee, Caitlin K Robinson, Adam R Ferguson, Hester F Lingsma, Maryse C Cnossen, Romain Pirracchio, Frederick K Korley, Mary J Vassar, Esther L Yuh, Pratik Mukherjee, Wayne A Gordon, Alex B Valadka, David O Okonkwo, Geoffrey T Manley
The relationship between blood alcohol level (BAL) and mild traumatic brain injury (mTBI) remains in need of improved characterization. Adult patients suffering mTBI without intracranial pathology on computed tomography (CT) from the prospective Transforming Research and Clinical Knowledge in Traumatic Brain Injury Pilot study with emergency department (ED) Glasgow Coma Scale (GCS) 13-15 and recorded blood alcohol level (BAL) were extracted. BAL≥80-mg/dl was set as proxy for excessive use. Multivariable regression was performed for patients with six-month Glasgow Outcome Scale-Extended (GOSE; functional recovery) and Wechsler Adult Intelligence Scale Processing Speed Index Composite Score (WAIS-PSI; nonverbal processing speed), using BAL≥80-mg/dl and <80-mg/dl cohorts, adjusting for demographic/injury factors...
August 5, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28781119/primary-antibiotic-resistance-in-helicobacter-pylori-in-the-asia-pacific-region-a-systematic-review-and-meta-analysis
#13
Yu-Ting Kuo, Jyh-Ming Liou, Emad M El-Omar, Jeng-Yih Wu, Alex Hwong Ruey Leow, Khean Lee Goh, Rajashree Das, Hong Lu, Jaw-Town Lin, Yu-Kang Tu, Yoshio Yamaoka, Ming-Shiang Wu
BACKGROUND: So far, a comprehensive systematic review and meta-analysis has not been done of the prevalence of primary antibiotic resistance in Helicobacter pylori in the Asia-Pacific region. We aimed to assess the trends and regional differences in primary antibiotic resistance to H pylori in the Asia-Pacific region and to examine the relation between resistance and first-line eradication. METHODS: We did a systematic review and meta-analysis of primary antibiotic resistance to H pylori and the efficacy of first-line regimens in the Asia-Pacific region...
August 3, 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28763166/comparison-of-three-methods-for-the-methylation-of-aliphatic-and-aromatic-compounds
#14
Hyejung Lee, Sarah J Feakins, Zhiyao Lu, Arndt Schimmelmann, Alex L Sessions, Jessica E Tierney, Travis J Williams
RATIONALE: Methylation protocols commonly call for acidic, hot conditions that are known to promote organic (1) H/(2) H exchange in aromatic and aliphatic C-H bonds. Here we tested two such commonly-used methods and compared a third that avoids these acidic conditions, to quantify isotope effects with each method and to directly determine acidic-exchange rates relevant to experimental conditions. METHODS: We compared acidic and non-acidic methylation approaches catalyzed by hydrochloric acid, acetyl chloride and EDCI (1-ethyl-3-(3-dimethylaminopropyl)carbodiimide) / DMAP (4-dimethylaminopyridine) respectively...
August 1, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28762251/h-pylori-management-in-asean-the-bangkok-consensus-report
#15
REVIEW
Varocha Mahachai, Ratha-Korn Vilaichone, Rapat Pittayanon, Jarin Rojborwonwitaya, Somchai Leelakusolvong, Monthira Maneerattanaporn, Peranart Chotivitayatarakorn, Sombat Treeprasertsuk, Chomsri Kositchaiwat, Pises Pisespongsa, Pisaln Mairiang, Aziz Rani, Alex Leow, Swe Mon Mya, Yi-Chia Lee, Sengdao Vannarath, Bouachanh Rasachak, Oung Chakravuth, Moe Myint Aung, Tiing-Leong Ang, Jose D Sollano, Duc Quach Trong, Inchaya Sansak, Olarn Wiwattanachang, Piyathida Harnsomburana, Ari Fahrial Syam, Yoshio Yamaoka, Kwong-Ming Fock, Khean-Lee Goh, Kentaro Sugano, David Graham
Helicobacter pylori (H. pylori) infection remains to be the major cause of important upper gastrointestinal diseases such as chronic gastritis, peptic ulcer, gastric adenocarcinoma and mucosa-associated lymphoid tissue (MALT) lymphoma. H. pylori management in ASEAN: the Bangkok consensus report gathered key opinion leaders for the region to review and evaluate clinical aspects of H. pylori infection and to develop consensus statements, rationales and grades of recommendation for the management of H. pylori infection in clinical practice in ASEAN countries...
July 31, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28760982/low-frequency-hippocampal-cortical-activity-drives-brain-wide-resting-state-functional-mri-connectivity
#16
Russell W Chan, Alex T L Leong, Leon C Ho, Patrick P Gao, Eddie C Wong, Celia M Dong, Xunda Wang, Jufang He, Ying-Shing Chan, Lee Wei Lim, Ed X Wu
The hippocampus, including the dorsal dentate gyrus (dDG), and cortex engage in bidirectional communication. We propose that low-frequency activity in hippocampal-cortical pathways contributes to brain-wide resting-state connectivity to integrate sensory information. Using optogenetic stimulation and brain-wide fMRI and resting-state fMRI (rsfMRI), we determined the large-scale effects of spatiotemporal-specific downstream propagation of hippocampal activity. Low-frequency (1 Hz), but not high-frequency (40 Hz), stimulation of dDG excitatory neurons evoked robust cortical and subcortical brain-wide fMRI responses...
August 15, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28750199/a-systems-approach-to-healthcare-innovation-using-the-mit-hacking-medicine-model
#17
Tatyana A Gubin, Hari P Iyer, Shirlene N Liew, Aartik Sarma, Alex Revelos, João Ribas, Babak Movassaghi, Zen M Chu, Ayesha N Khalid, Maulik D Majmudar, Christopher Xiang Lee
MIT Hacking Medicine is a student, academic, and community-led organization that uses systems-oriented "healthcare hacking" to address challenges around innovation in healthcare. The group has organized more than 80 events around the world that attract participants with diverse backgrounds. These participants are trained to address clinical needs from the perspective of multiple stakeholders and emphasize utility and implementation viability of proposed solutions. We describe the MIT Hacking Medicine model as a potential method to integrate collaboration and training in rapid innovation techniques into academic medical centers...
July 26, 2017: Cell Systems
https://www.readbyqxmd.com/read/28745509/contact-angle-and-adhesion-dynamics-and-hysteresis-on-molecularly-smooth-chemically-homogeneous-surfaces
#18
Szu-Ying Chen, Yair Kaufman, Alex M Schrader, Dongjin Seo, Dong Woog Lee, Steven H Page, Peter H Koenig, Sandra Isaacs, Yonas Gizaw, Jacob N Israelachvili
Measuring truly equilibrium adhesion energies or contact angles to obtain the thermodynamic values is experimentally difficult because it requires loading/unloading or advancing/receding boundaries to be measured at rates that can be slower than 1 nm/s. We have measured advancing-receding contact angles and loading-unloading adhesion energies for various systems and geometries involving molecularly smooth and chemically homogeneous surfaces moving at different but steady velocities in both directions, ±V, focusing on the thermodynamic limit of ±V → 0...
August 29, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28737409/low-buffer-capacity-and-alternating-motility-along-the-human-gastrointestinal-tract-implications-for-in-vivo-dissolution-and-absorption-of-ionizable-drugs
#19
Bart Hens, Yasuhiro Tsume, Marival Bermejo, Paulo Paixao, Mark J Koenigsknecht, Jason R Baker, William L Hasler, Robert Lionberger, Jianghong Fan, Joseph Dickens, Kerby Shedden, Bo Wen, Jeffrey Wysocki, Raimar Loebenberg, Allen Lee, Ann Frances, Greg Amidon, Alex Yu, Gail Benninghoff, Niloufar Salehi, Arjang Talattof, Duxin Sun, Gordon L Amidon
In this study, we determined the pH and buffer capacity of human gastrointestinal (GI) fluids (aspirated from the stomach, duodenum, proximal jejunum, and mid/distal jejunum) as a function of time, from 37 healthy subjects after oral administration of an 800 mg immediate-release tablet of ibuprofen (reference listed drug; RLD) under typical prescribed bioequivalence (BE) study protocol conditions in both fasted and fed states (simulated by ingestion of a liquid meal). Simultaneously, motility was continuously monitored using water-perfused manometry...
August 4, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28730651/a-comparison-of-the-electrophysiologic-and-electroanatomic-characteristics-between-the-right-and-left-atrium-in-persistent-atrial-fibrillation-is-the-right-atrium-a-window-into-the-left
#20
Sandeep Prabhu, Aleksandr Voskoboinik, Alex J A McLellan, Kah Y Peck, Bhupesh Pathik, Chrishan J Nalliah, Geoff R Wong, Sonia M Azzopardi, Geoffrey Lee, Justin Mariani, Liang-Han Ling, Andrew J Taylor, Jonathan M Kalman, Peter M Kistler
INTRODUCTION: The right atrium (RA) is readily accessible; however, it is unclear whether changes in the RA are representative of the LA. We performed detailed biatrial electroanatomic mapping to determine the electrophysiological relationship between the atria. METHODS AND RESULTS: Consecutive patients with persistent AF underwent biatrial electroanatomical mapping with a contact force catheter acquiring points with a CF >10 g prior to ablation. Points were analyzed for tissue voltage, complex electrograms, low voltage (<0...
July 21, 2017: Journal of Cardiovascular Electrophysiology
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