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Christopher C. Thompson

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https://www.readbyqxmd.com/read/29930110/analysis-of-shared-heritability-in-common-disorders-of-the-brain
#1
Verneri Anttila, Brendan Bulik-Sullivan, Hilary K Finucane, Raymond K Walters, Jose Bras, Laramie Duncan, Valentina Escott-Price, Guido J Falcone, Padhraig Gormley, Rainer Malik, Nikolaos A Patsopoulos, Stephan Ripke, Zhi Wei, Dongmei Yu, Phil H Lee, Patrick Turley, Benjamin Grenier-Boley, Vincent Chouraki, Yoichiro Kamatani, Claudine Berr, Luc Letenneur, Didier Hannequin, Philippe Amouyel, Anne Boland, Jean-François Deleuze, Emmanuelle Duron, Badri N Vardarajan, Christiane Reitz, Alison M Goate, Matthew J Huentelman, M Ilyas Kamboh, Eric B Larson, Ekaterina Rogaeva, Peter St George-Hyslop, Hakon Hakonarson, Walter A Kukull, Lindsay A Farrer, Lisa L Barnes, Thomas G Beach, F Yesim Demirci, Elizabeth Head, Christine M Hulette, Gregory A Jicha, John S K Kauwe, Jeffrey A Kaye, James B Leverenz, Allan I Levey, Andrew P Lieberman, Vernon S Pankratz, Wayne W Poon, Joseph F Quinn, Andrew J Saykin, Lon S Schneider, Amanda G Smith, Joshua A Sonnen, Robert A Stern, Vivianna M Van Deerlin, Linda J Van Eldik, Denise Harold, Giancarlo Russo, David C Rubinsztein, Anthony Bayer, Magda Tsolaki, Petra Proitsi, Nick C Fox, Harald Hampel, Michael J Owen, Simon Mead, Peter Passmore, Kevin Morgan, Markus M Nöthen, Martin Rossor, Michelle K Lupton, Per Hoffmann, Johannes Kornhuber, Brian Lawlor, Andrew McQuillin, Ammar Al-Chalabi, Joshua C Bis, Agustin Ruiz, Mercè Boada, Sudha Seshadri, Alexa Beiser, Kenneth Rice, Sven J van der Lee, Philip L De Jager, Daniel H Geschwind, Matthias Riemenschneider, Steffi Riedel-Heller, Jerome I Rotter, Gerhard Ransmayr, Bradley T Hyman, Carlos Cruchaga, Montserrat Alegret, Bendik Winsvold, Priit Palta, Kai-How Farh, Ester Cuenca-Leon, Nicholas Furlotte, Tobias Kurth, Lannie Ligthart, Gisela M Terwindt, Tobias Freilinger, Caroline Ran, Scott D Gordon, Guntram Borck, Hieab H H Adams, Terho Lehtimäki, Juho Wedenoja, Julie E Buring, Markus Schürks, Maria Hrafnsdottir, Jouke-Jan Hottenga, Brenda Penninx, Ville Artto, Mari Kaunisto, Salli Vepsäläinen, Nicholas G Martin, Grant W Montgomery, Mitja I Kurki, Eija Hämäläinen, Hailiang Huang, Jie Huang, Cynthia Sandor, Caleb Webber, Bertram Muller-Myhsok, Stefan Schreiber, Veikko Salomaa, Elizabeth Loehrer, Hartmut Göbel, Alfons Macaya, Patricia Pozo-Rosich, Thomas Hansen, Thomas Werge, Jaakko Kaprio, Andres Metspalu, Christian Kubisch, Michel D Ferrari, Andrea C Belin, Arn M J M van den Maagdenberg, John-Anker Zwart, Dorret Boomsma, Nicholas Eriksson, Jes Olesen, Daniel I Chasman, Dale R Nyholt, Andreja Avbersek, Larry Baum, Samuel Berkovic, Jonathan Bradfield, Russell Buono, Claudia B Catarino, Patrick Cossette, Peter De Jonghe, Chantal Depondt, Dennis Dlugos, Thomas N Ferraro, Jacqueline French, Helle Hjalgrim, Jennifer Jamnadas-Khoda, Reetta Kälviäinen, Wolfram S Kunz, Holger Lerche, Costin Leu, Dick Lindhout, Warren Lo, Daniel Lowenstein, Mark McCormack, Rikke S Møller, Anne Molloy, Ping-Wing Ng, Karen Oliver, Michael Privitera, Rodney Radtke, Ann-Kathrin Ruppert, Thomas Sander, Steven Schachter, Christoph Schankin, Ingrid Scheffer, Susanne Schoch, Sanjay M Sisodiya, Philip Smith, Michael Sperling, Pasquale Striano, Rainer Surges, G Neil Thomas, Frank Visscher, Christopher D Whelan, Federico Zara, Erin L Heinzen, Anthony Marson, Felicitas Becker, Hans Stroink, Fritz Zimprich, Thomas Gasser, Raphael Gibbs, Peter Heutink, Maria Martinez, Huw R Morris, Manu Sharma, Mina Ryten, Kin Y Mok, Sara Pulit, Steve Bevan, Elizabeth Holliday, John Attia, Thomas Battey, Giorgio Boncoraglio, Vincent Thijs, Wei-Min Chen, Braxton Mitchell, Peter Rothwell, Pankaj Sharma, Cathie Sudlow, Astrid Vicente, Hugh Markus, Christina Kourkoulis, Joana Pera, Miriam Raffeld, Scott Silliman, Vesna Boraska Perica, Laura M Thornton, Laura M Huckins, N William Rayner, Cathryn M Lewis, Monica Gratacos, Filip Rybakowski, Anna Keski-Rahkonen, Anu Raevuori, James I Hudson, Ted Reichborn-Kjennerud, Palmiero Monteleone, Andreas Karwautz, Katrin Mannik, Jessica H Baker, Julie K O'Toole, Sara E Trace, Oliver S P Davis, Sietske G Helder, Stefan Ehrlich, Beate Herpertz-Dahlmann, Unna N Danner, Annemarie A van Elburg, Maurizio Clementi, Monica Forzan, Elisa Docampo, Jolanta Lissowska, Joanna Hauser, Alfonso Tortorella, Mario Maj, Fragiskos Gonidakis, Konstantinos Tziouvas, Hana Papezova, Zeynep Yilmaz, Gudrun Wagner, Sarah Cohen-Woods, Stefan Herms, Antonio Julià, Raquel Rabionet, Danielle M Dick, Samuli Ripatti, Ole A Andreassen, Thomas Espeseth, Astri J Lundervold, Vidar M Steen, Dalila Pinto, Stephen W Scherer, Harald Aschauer, Alexandra Schosser, Lars Alfredsson, Leonid Padyukov, Katherine A Halmi, James Mitchell, Michael Strober, Andrew W Bergen, Walter Kaye, Jin Peng Szatkiewicz, Bru Cormand, Josep Antoni Ramos-Quiroga, Cristina Sánchez-Mora, Marta Ribasés, Miguel Casas, Amaia Hervas, Maria Jesús Arranz, Jan Haavik, Tetyana Zayats, Stefan Johansson, Nigel Williams, Astrid Dempfle, Aribert Rothenberger, Jonna Kuntsi, Robert D Oades, Tobias Banaschewski, Barbara Franke, Jan K Buitelaar, Alejandro Arias Vasquez, Alysa E Doyle, Andreas Reif, Klaus-Peter Lesch, Christine Freitag, Olga Rivero, Haukur Palmason, Marcel Romanos, Kate Langley, Marcella Rietschel, Stephanie H Witt, Soeren Dalsgaard, Anders D Børglum, Irwin Waldman, Beth Wilmot, Nikolas Molly, Claiton H D Bau, Jennifer Crosbie, Russell Schachar, Sandra K Loo, James J McGough, Eugenio H Grevet, Sarah E Medland, Elise Robinson, Lauren A Weiss, Elena Bacchelli, Anthony Bailey, Vanessa Bal, Agatino Battaglia, Catalina Betancur, Patrick Bolton, Rita Cantor, Patrícia Celestino-Soper, Geraldine Dawson, Silvia De Rubeis, Frederico Duque, Andrew Green, Sabine M Klauck, Marion Leboyer, Pat Levitt, Elena Maestrini, Shrikant Mane, Daniel Moreno- De-Luca, Jeremy Parr, Regina Regan, Abraham Reichenberg, Sven Sandin, Jacob Vorstman, Thomas Wassink, Ellen Wijsman, Edwin Cook, Susan Santangelo, Richard Delorme, Bernadette Rogé, Tiago Magalhaes, Dan Arking, Thomas G Schulze, Robert C Thompson, Jana Strohmaier, Keith Matthews, Ingrid Melle, Derek Morris, Douglas Blackwood, Andrew McIntosh, Sarah E Bergen, Martin Schalling, Stéphane Jamain, Anna Maaser, Sascha B Fischer, Céline S Reinbold, Janice M Fullerton, José Guzman-Parra, Fermin Mayoral, Peter R Schofield, Sven Cichon, Thomas W Mühleisen, Franziska Degenhardt, Johannes Schumacher, Michael Bauer, Philip B Mitchell, Elliot S Gershon, John Rice, James B Potash, Peter P Zandi, Nick Craddock, I Nicol Ferrier, Martin Alda, Guy A Rouleau, Gustavo Turecki, Roel Ophoff, Carlos Pato, Adebayo Anjorin, Eli Stahl, Markus Leber, Piotr M Czerski, Cristiana Cruceanu, Ian R Jones, Danielle Posthuma, Till F M Andlauer, Andreas J Forstner, Fabian Streit, Bernhard T Baune, Tracy Air, Grant Sinnamon, Naomi R Wray, Donald J MacIntyre, David Porteous, Georg Homuth, Margarita Rivera, Jakob Grove, Christel M Middeldorp, Ian Hickie, Michele Pergadia, Divya Mehta, Johannes H Smit, Rick Jansen, Eco de Geus, Erin Dunn, Qingqin S Li, Matthias Nauck, Robert A Schoevers, Aartjan Tf Beekman, James A Knowles, Alexander Viktorin, Paul Arnold, Cathy L Barr, Gabriel Bedoya-Berrio, O Joseph Bienvenu, Helena Brentani, Christie Burton, Beatriz Camarena, Carolina Cappi, Danielle Cath, Maria Cavallini, Daniele Cusi, Sabrina Darrow, Damiaan Denys, Eske M Derks, Andrea Dietrich, Thomas Fernandez, Martijn Figee, Nelson Freimer, Gloria Gerber, Marco Grados, Erica Greenberg, Gregory L Hanna, Andreas Hartmann, Matthew E Hirschtritt, Pieter J Hoekstra, Alden Huang, Chaim Huyser, Cornelia Illmann, Michael Jenike, Samuel Kuperman, Bennett Leventhal, Christine Lochner, Gholson J Lyon, Fabio Macciardi, Marcos Madruga-Garrido, Irene A Malaty, Athanasios Maras, Lauren McGrath, Eurípedes C Miguel, Pablo Mir, Gerald Nestadt, Humberto Nicolini, Michael S Okun, Andrew Pakstis, Peristera Paschou, John Piacentini, Christopher Pittenger, Kerstin Plessen, Vasily Ramensky, Eliana M Ramos, Victor Reus, Margaret A Richter, Mark A Riddle, Mary M Robertson, Veit Roessner, Maria Rosário, Jack F Samuels, Paul Sandor, Dan J Stein, Fotis Tsetsos, Filip Van Nieuwerburgh, Sarah Weatherall, Jens R Wendland, Tomasz Wolanczyk, Yulia Worbe, Gwyneth Zai, Fernando S Goes, Nicole McLaughlin, Paul S Nestadt, Hans-Jorgen Grabe, Christel Depienne, Anuar Konkashbaev, Nuria Lanzagorta, Ana Valencia-Duarte, Elvira Bramon, Nancy Buccola, Wiepke Cahn, Murray Cairns, Siow A Chong, David Cohen, Benedicto Crespo-Facorro, James Crowley, Michael Davidson, Lynn DeLisi, Timothy Dinan, Gary Donohoe, Elodie Drapeau, Jubao Duan, Lieuwe Haan, David Hougaard, Sena Karachanak-Yankova, Andrey Khrunin, Janis Klovins, Vaidutis Kučinskas, Jimmy Lee Chee Keong, Svetlana Limborska, Carmel Loughland, Jouko Lönnqvist, Brion Maher, Manuel Mattheisen, Colm McDonald, Kieran C Murphy, Igor Nenadic, Jim van Os, Christos Pantelis, Michele Pato, Tracey Petryshen, Digby Quested, Panos Roussos, Alan R Sanders, Ulrich Schall, Sibylle G Schwab, Kang Sim, Hon-Cheong So, Elisabeth Stögmann, Mythily Subramaniam, Draga Toncheva, John Waddington, James Walters, Mark Weiser, Wei Cheng, Robert Cloninger, David Curtis, Pablo V Gejman, Frans Henskens, Morten Mattingsdal, Sang-Yun Oh, Rodney Scott, Bradley Webb, Gerome Breen, Claire Churchhouse, Cynthia M Bulik, Mark Daly, Martin Dichgans, Stephen V Faraone, Rita Guerreiro, Peter Holmans, Kenneth S Kendler, Bobby Koeleman, Carol A Mathews, Alkes Price, Jeremiah Scharf, Pamela Sklar, Julie Williams, Nicholas W Wood, Chris Cotsapas, Aarno Palotie, Jordan W Smoller, Patrick Sullivan, Jonathan Rosand, Aiden Corvin, Benjamin M Neale
Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common variant risk, whereas neurological disorders appear more distinct from one another and from the psychiatric disorders...
June 22, 2018: Science
https://www.readbyqxmd.com/read/29905176/endoscopic-submucosal-dissection-pocket-technique-for-removal-of-recurrent-colonic-lesion
#2
Hiroyuki Aihara, Matthew J Skinner, Christopher C Thompson
No abstract text is available yet for this article.
February 2018: VideoGIE: an official video journal of the American Society for Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29895892/large-scale-mapping-of-cortical-alterations-in-22q11-2-deletion-syndrome-convergence-with-idiopathic-psychosis-and-effects-of-deletion-size
#3
Daqiang Sun, Christopher R K Ching, Amy Lin, Jennifer K Forsyth, Leila Kushan, Ariana Vajdi, Maria Jalbrzikowski, Laura Hansen, Julio E Villalon-Reina, Xiaoping Qu, Rachel K Jonas, Therese van Amelsvoort, Geor Bakker, Wendy R Kates, Kevin M Antshel, Wanda Fremont, Linda E Campbell, Kathryn L McCabe, Eileen Daly, Maria Gudbrandsen, Clodagh M Murphy, Declan Murphy, Michael Craig, Jacob Vorstman, Ania Fiksinski, Sanne Koops, Kosha Ruparel, David R Roalf, Raquel E Gur, J Eric Schmitt, Tony J Simon, Naomi J Goodrich-Hunsaker, Courtney A Durdle, Anne S Bassett, Eva W C Chow, Nancy J Butcher, Fidel Vila-Rodriguez, Joanne Doherty, Adam Cunningham, Marianne B M van den Bree, David E J Linden, Hayley Moss, Michael J Owen, Kieran C Murphy, Donna M McDonald-McGinn, Beverly Emanuel, Theo G M van Erp, Jessica A Turner, Paul M Thompson, Carrie E Bearden
The 22q11.2 deletion (22q11DS) is a common chromosomal microdeletion and a potent risk factor for psychotic illness. Prior studies reported widespread cortical changes in 22q11DS, but were generally underpowered to characterize neuroanatomic abnormalities associated with psychosis in 22q11DS, and/or neuroanatomic effects of variability in deletion size. To address these issues, we developed the ENIGMA (Enhancing Neuro Imaging Genetics Through Meta-Analysis) 22q11.2 Working Group, representing the largest analysis of brain structural alterations in 22q11DS to date...
June 13, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29892050/fine-mapping-of-prostate-cancer-susceptibility-loci-in-a-large-meta-analysis-identifies-candidate-causal-variants
#4
Tokhir Dadaev, Edward J Saunders, Paul J Newcombe, Ezequiel Anokian, Daniel A Leongamornlert, Mark N Brook, Clara Cieza-Borrella, Martina Mijuskovic, Sarah Wakerell, Ali Amin Al Olama, Fredrick R Schumacher, Sonja I Berndt, Sara Benlloch, Mahbubl Ahmed, Chee Goh, Xin Sheng, Zhuo Zhang, Kenneth Muir, Koveela Govindasami, Artitaya Lophatananon, Victoria L Stevens, Susan M Gapstur, Brian D Carter, Catherine M Tangen, Phyllis Goodman, Ian M Thompson, Jyotsna Batra, Suzanne Chambers, Leire Moya, Judith Clements, Lisa Horvath, Wayne Tilley, Gail Risbridger, Henrik Gronberg, Markus Aly, Tobias Nordström, Paul Pharoah, Nora Pashayan, Johanna Schleutker, Teuvo L J Tammela, Csilla Sipeky, Anssi Auvinen, Demetrius Albanes, Stephanie Weinstein, Alicja Wolk, Niclas Hakansson, Catharine West, Alison M Dunning, Neil Burnet, Lorelei Mucci, Edward Giovannucci, Gerald Andriole, Olivier Cussenot, Géraldine Cancel-Tassin, Stella Koutros, Laura E Beane Freeman, Karina Dalsgaard Sorensen, Torben Falck Orntoft, Michael Borre, Lovise Maehle, Eli Marie Grindedal, David E Neal, Jenny L Donovan, Freddie C Hamdy, Richard M Martin, Ruth C Travis, Tim J Key, Robert J Hamilton, Neil E Fleshner, Antonio Finelli, Sue Ann Ingles, Mariana C Stern, Barry Rosenstein, Sarah Kerns, Harry Ostrer, Yong-Jie Lu, Hong-Wei Zhang, Ninghan Feng, Xueying Mao, Xin Guo, Guomin Wang, Zan Sun, Graham G Giles, Melissa C Southey, Robert J MacInnis, Liesel M FitzGerald, Adam S Kibel, Bettina F Drake, Ana Vega, Antonio Gómez-Caamaño, Laura Fachal, Robert Szulkin, Martin Eklund, Manolis Kogevinas, Javier Llorca, Gemma Castaño-Vinyals, Kathryn L Penney, Meir Stampfer, Jong Y Park, Thomas A Sellers, Hui-Yi Lin, Janet L Stanford, Cezary Cybulski, Dominika Wokolorczyk, Jan Lubinski, Elaine A Ostrander, Milan S Geybels, Børge G Nordestgaard, Sune F Nielsen, Maren Weisher, Rasmus Bisbjerg, Martin Andreas Røder, Peter Iversen, Hermann Brenner, Katarina Cuk, Bernd Holleczek, Christiane Maier, Manuel Luedeke, Thomas Schnoeller, Jeri Kim, Christopher J Logothetis, Esther M John, Manuel R Teixeira, Paula Paulo, Marta Cardoso, Susan L Neuhausen, Linda Steele, Yuan Chun Ding, Kim De Ruyck, Gert De Meerleer, Piet Ost, Azad Razack, Jasmine Lim, Soo-Hwang Teo, Daniel W Lin, Lisa F Newcomb, Davor Lessel, Marija Gamulin, Tomislav Kulis, Radka Kaneva, Nawaid Usmani, Chavdar Slavov, Vanio Mitev, Matthew Parliament, Sandeep Singhal, Frank Claessens, Steven Joniau, Thomas Van den Broeck, Samantha Larkin, Paul A Townsend, Claire Aukim-Hastie, Manuela Gago-Dominguez, Jose Esteban Castelao, Maria Elena Martinez, Monique J Roobol, Guido Jenster, Ron H N van Schaik, Florence Menegaux, Thérèse Truong, Yves Akoli Koudou, Jianfeng Xu, Kay-Tee Khaw, Lisa Cannon-Albright, Hardev Pandha, Agnieszka Michael, Andrzej Kierzek, Stephen N Thibodeau, Shannon K McDonnell, Daniel J Schaid, Sara Lindstrom, Constance Turman, Jing Ma, David J Hunter, Elio Riboli, Afshan Siddiq, Federico Canzian, Laurence N Kolonel, Loic Le Marchand, Robert N Hoover, Mitchell J Machiela, Peter Kraft, Matthew Freedman, Fredrik Wiklund, Stephen Chanock, Brian E Henderson, Douglas F Easton, Christopher A Haiman, Rosalind A Eeles, David V Conti, Zsofia Kote-Jarai
Prostate cancer is a polygenic disease with a large heritable component. A number of common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here we apply the Bayesian multivariate variable selection algorithm JAM to fine-map 84 prostate cancer susceptibility loci, using summary data from a large European ancestry meta-analysis. We observe evidence for multiple independent signals at 12 regions and 99 risk signals overall. Only 15 original GWAS tag SNPs remain among the catalogue of candidate variants identified; the remainder are replaced by more likely candidates...
June 11, 2018: Nature Communications
https://www.readbyqxmd.com/read/29892016/association-analyses-of-more-than-140-000-men-identify-63-new-prostate-cancer-susceptibility-loci
#5
Fredrick R Schumacher, Ali Amin Al Olama, Sonja I Berndt, Sara Benlloch, Mahbubl Ahmed, Edward J Saunders, Tokhir Dadaev, Daniel Leongamornlert, Ezequiel Anokian, Clara Cieza-Borrella, Chee Goh, Mark N Brook, Xin Sheng, Laura Fachal, Joe Dennis, Jonathan Tyrer, Kenneth Muir, Artitaya Lophatananon, Victoria L Stevens, Susan M Gapstur, Brian D Carter, Catherine M Tangen, Phyllis J Goodman, Ian M Thompson, Jyotsna Batra, Suzanne Chambers, Leire Moya, Judith Clements, Lisa Horvath, Wayne Tilley, Gail P Risbridger, Henrik Gronberg, Markus Aly, Tobias Nordström, Paul Pharoah, Nora Pashayan, Johanna Schleutker, Teuvo L J Tammela, Csilla Sipeky, Anssi Auvinen, Demetrius Albanes, Stephanie Weinstein, Alicja Wolk, Niclas Håkansson, Catharine M L West, Alison M Dunning, Neil Burnet, Lorelei A Mucci, Edward Giovannucci, Gerald L Andriole, Olivier Cussenot, Géraldine Cancel-Tassin, Stella Koutros, Laura E Beane Freeman, Karina Dalsgaard Sorensen, Torben Falck Orntoft, Michael Borre, Lovise Maehle, Eli Marie Grindedal, David E Neal, Jenny L Donovan, Freddie C Hamdy, Richard M Martin, Ruth C Travis, Tim J Key, Robert J Hamilton, Neil E Fleshner, Antonio Finelli, Sue Ann Ingles, Mariana C Stern, Barry S Rosenstein, Sarah L Kerns, Harry Ostrer, Yong-Jie Lu, Hong-Wei Zhang, Ninghan Feng, Xueying Mao, Xin Guo, Guomin Wang, Zan Sun, Graham G Giles, Melissa C Southey, Robert J MacInnis, Liesel M FitzGerald, Adam S Kibel, Bettina F Drake, Ana Vega, Antonio Gómez-Caamaño, Robert Szulkin, Martin Eklund, Manolis Kogevinas, Javier Llorca, Gemma Castaño-Vinyals, Kathryn L Penney, Meir Stampfer, Jong Y Park, Thomas A Sellers, Hui-Yi Lin, Janet L Stanford, Cezary Cybulski, Dominika Wokolorczyk, Jan Lubinski, Elaine A Ostrander, Milan S Geybels, Børge G Nordestgaard, Sune F Nielsen, Maren Weischer, Rasmus Bisbjerg, Martin Andreas Røder, Peter Iversen, Hermann Brenner, Katarina Cuk, Bernd Holleczek, Christiane Maier, Manuel Luedeke, Thomas Schnoeller, Jeri Kim, Christopher J Logothetis, Esther M John, Manuel R Teixeira, Paula Paulo, Marta Cardoso, Susan L Neuhausen, Linda Steele, Yuan Chun Ding, Kim De Ruyck, Gert De Meerleer, Piet Ost, Azad Razack, Jasmine Lim, Soo-Hwang Teo, Daniel W Lin, Lisa F Newcomb, Davor Lessel, Marija Gamulin, Tomislav Kulis, Radka Kaneva, Nawaid Usmani, Sandeep Singhal, Chavdar Slavov, Vanio Mitev, Matthew Parliament, Frank Claessens, Steven Joniau, Thomas Van den Broeck, Samantha Larkin, Paul A Townsend, Claire Aukim-Hastie, Manuela Gago Dominguez, Jose Esteban Castelao, Maria Elena Martinez, Monique J Roobol, Guido Jenster, Ron H N van Schaik, Florence Menegaux, Thérèse Truong, Yves Akoli Koudou, Jianfeng Xu, Kay-Tee Khaw, Lisa Cannon-Albright, Hardev Pandha, Agnieszka Michael, Stephen N Thibodeau, Shannon K McDonnell, Daniel J Schaid, Sara Lindstrom, Constance Turman, Jing Ma, David J Hunter, Elio Riboli, Afshan Siddiq, Federico Canzian, Laurence N Kolonel, Loic Le Marchand, Robert N Hoover, Mitchell J Machiela, Zuxi Cui, Peter Kraft, Christopher I Amos, David V Conti, Douglas F Easton, Fredrik Wiklund, Stephen J Chanock, Brian E Henderson, Zsofia Kote-Jarai, Christopher A Haiman, Rosalind A Eeles
Genome-wide association studies (GWAS) and fine-mapping efforts to date have identified more than 100 prostate cancer (PrCa)-susceptibility loci. We meta-analyzed genotype data from a custom high-density array of 46,939 PrCa cases and 27,910 controls of European ancestry with previously genotyped data of 32,255 PrCa cases and 33,202 controls of European ancestry. Our analysis identified 62 novel loci associated (P < 5.0 × 10-8 ) with PrCa and one locus significantly associated with early-onset PrCa (≤55 years)...
June 11, 2018: Nature Genetics
https://www.readbyqxmd.com/read/29882736/complications-following-pediatric-cranioplasty-after-decompressive-craniectomy-a-multicenter-retrospective-study
#6
Brandon G Rocque, Bonita S Agee, Eric M Thompson, Mark Piedra, Lissa C Baird, Nathan R Selden, Stephanie Greene, Christopher P Deibert, Todd C Hankinson, Sean M Lew, Bermans J Iskandar, Taryn M Bragg, David Frim, Gerald Grant, Nalin Gupta, Kurtis I Auguste, Dimitrios C Nikas, Michael Vassilyadi, Carrie R Muh, Nicholas M Wetjen, Sandi K Lam
OBJECTIVE In children, the repair of skull defects arising from decompressive craniectomy presents a unique set of challenges. Single-center studies have identified different risk factors for the common complications of cranioplasty resorption and infection. The goal of the present study was to determine the risk factors for bone resorption and infection after pediatric cranioplasty. METHODS The authors conducted a multicenter retrospective case study that included all patients who underwent cranioplasty to correct a skull defect arising from a decompressive craniectomy at 13 centers between 2000 and 2011 and were less than 19 years old at the time of cranioplasty...
June 8, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29869518/selective-osmotic-shock-for-islet-isolation-in-the-cadaveric-canine-pancreas
#7
Elizabeth M Thompson, Jennifer L Sollinger, Emmanuel C Opara, Christopher A Adin
Currently, islet isolation is performed using harsh collagenases that cause nonspecific injury to both islets and exocrine tissue, negatively affecting the outcome of cell transplantation. We evaluated a novel islet isolation protocol utilizing high concentrations of glucose to cause selective osmotic shock (SOS). Islets have a membrane glucose transporter that allows adaptation to changes in glucose concentrations while exocrine tissue can be selectively destroyed by these osmolar shifts. Canine pancreata were obtained within 15 min after euthanasia from animals ( n = 6) euthanized for reasons unrelated to this study...
March 2018: Cell Transplantation
https://www.readbyqxmd.com/read/29861849/real-time-scratch-assay-reveals-mechanisms-of-early-calcium-signaling-in-breast-cancer-cells-in-response-to-wounding
#8
Stephen J P Pratt, Erick O Hernández-Ochoa, Rachel M Lee, Eleanor C Ory, James S Lyons, Humberto C Joca, Ashley Johnson, Keyata Thompson, Patrick Bailey, Cornell J Lee, Trevor Mathias, Michele I Vitolo, Matt Trudeau, Joseph P Stains, Christopher W Ward, Martin F Schneider, Stuart S Martin
Aggressive cellular phenotypes such as uncontrolled proliferation and increased migration capacity engender cellular transformation, malignancy and metastasis. While genetic mutations are undisputed drivers of cancer initiation and progression, it is increasingly accepted that external factors are also playing a major role. Two recently studied modulators of breast cancer are changes in the cellular mechanical microenvironment and alterations in calcium homeostasis. While many studies investigate these factors separately in breast cancer cells, very few do so in combination...
May 18, 2018: Oncotarget
https://www.readbyqxmd.com/read/29848573/prospective-analysis-of-adoptive-til-therapy-in-patients-with-metastatic-melanoma-response-impact-of-anti-ctla4-and-biomarkers-to-predict-clinical-outcome
#9
Marie-Andrée Forget, Cara Haymaker, Kenneth R Hess, Yuzhong Jeff Meng, Caitlin Creasy, Tatiana V Karpinets, Orenthial J Fulbright, Jason Roszik, Scott E Woodman, Young Uk Kim, Donastas Sakellariou-Thompson, Ankit Bhatta, Arely Wahl, Esteban Flores, Shawne T Thorsen, Rene J Tavera, Renjith Ramachandran, Audrey M Gonzalez, Christopher Toth, Seth Wardell, Rahmatu Mansaray, Vruti Patel, Destiny Joy Carpio, Carol S Vaughn, Chantell M Farinas, Portia G Velasquez, Wen-Jen Hwu, Sapna P Patel, Michael A Davies, Adi Diab, Isabella C Glitza, Hussein Tawbi, Michael K K Wong, Suzanne Cain, Merrick I Ross, Jeffrey E Lee, Jeffrey E Gershenwald, Anthony Lucci, Richard Royal, J N Cormier, Jennifer A Wargo, Laszlo G Radvanyi, Carlos A Torres Cabala, Rameen Beroukhim, Patrick Hwu, Rodabe N Amaria, Chantale Bernatchez
PURPOSE: Adoptive cell therapy (ACT) using tumor-infiltrating lymphocytes (TIL) has consistently demonstrated clinical efficacy in metastatic melanoma. Recent widespread use of checkpoint blockade has shifted the treatment landscape, raising questions regarding impact of these therapies on response to TIL and appropriate immunotherapy sequence. EXPERIMENTAL DESIGN: Seventy-four metastatic melanoma patients were treated with autologous TIL and evaluated for clinical response according to irRC, overall survival and progression free survival...
May 30, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29843811/first-results-on-survival-from-a-large-phase-3-clinical-trial-of-an-autologous-dendritic-cell-vaccine-in-newly-diagnosed-glioblastoma
#10
Linda M Liau, Keyoumars Ashkan, David D Tran, Jian L Campian, John E Trusheim, Charles S Cobbs, Jason A Heth, Michael Salacz, Sarah Taylor, Stacy D D'Andre, Fabio M Iwamoto, Edward J Dropcho, Yaron A Moshel, Kevin A Walter, Clement P Pillainayagam, Robert Aiken, Rekha Chaudhary, Samuel A Goldlust, Daniela A Bota, Paul Duic, Jai Grewal, Heinrich Elinzano, Steven A Toms, Kevin O Lillehei, Tom Mikkelsen, Tobias Walpert, Steven R Abram, Andrew J Brenner, Steven Brem, Matthew G Ewend, Simon Khagi, Jana Portnow, Lyndon J Kim, William G Loudon, Reid C Thompson, David E Avigan, Karen L Fink, Francois J Geoffroy, Scott Lindhorst, Jose Lutzky, Andrew E Sloan, Gabriele Schackert, Dietmar Krex, Hans-Jorg Meisel, Julian Wu, Raphael P Davis, Christopher Duma, Arnold B Etame, David Mathieu, Santosh Kesari, David Piccioni, Manfred Westphal, David S Baskin, Pamela Z New, Michel Lacroix, Sven-Axel May, Timothy J Pluard, Victor Tse, Richard M Green, John L Villano, Michael Pearlman, Kevin Petrecca, Michael Schulder, Lynne P Taylor, Anthony E Maida, Robert M Prins, Timothy F Cloughesy, Paul Mulholland, Marnix L Bosch
BACKGROUND: Standard therapy for glioblastoma includes surgery, radiotherapy, and temozolomide. This Phase 3 trial evaluates the addition of an autologous tumor lysate-pulsed dendritic cell vaccine (DCVax® -L) to standard therapy for newly diagnosed glioblastoma. METHODS: After surgery and chemoradiotherapy, patients were randomized (2:1) to receive temozolomide plus DCVax-L (n = 232) or temozolomide and placebo (n = 99). Following recurrence, all patients were allowed to receive DCVax-L, without unblinding...
May 29, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29812901/nci-program-for-natural-product-discovery-a-publicly-accessible-library-of-natural-product-fractions-for-high-throughput-screening
#11
Christopher C Thornburg, John R Britt, Jason R Evans, Rhone K Akee, James A Whitt, Spencer K Trinh, Matthew J Harris, Jerell R Thompson, Teresa L Ewing, Suzanne M Shipley, Paul G Grothaus, David J Newman, Tanja Grkovic, Barry R O'Keefe
The US National Cancer Institute's (NCI) Natural Product Repository is one of the world's largest, most diverse collections of natural products containing over 230,000 unique extracts derived from plant, marine and microbial organisms that have been collected from biodiverse regions throughout the world. Importantly, this national resource is available to the research community for the screening of extracts and the isolation of bioactive natural products. However, despite the success of natural products in drug discovery, compatibility issues that make extracts challenging for liquid handling systems, extended timelines that complicate natural product-based drug discovery efforts and the presence of pan-assay interfering compounds have reduced enthusiasm for the high-throughput screening (HTS) of crude natural product extract libraries in targeted assay systems...
May 29, 2018: ACS Chemical Biology
https://www.readbyqxmd.com/read/29803026/accumulate-or-eliminate-seasonal-mercury-dynamics-in-albatrosses-the-most-contaminated-family-of-birds
#12
Yves Cherel, Christophe Barbraud, Maxime Lahournat, Audrey Jaeger, Sébastien Jaquemet, Ross M Wanless, Richard A Phillips, David R Thompson, Paco Bustamante
Albatrosses (Diomedeidae) are iconic pelagic seabirds whose life-history traits (longevity, high trophic position) put them at risk of high levels of exposure to methylmercury (MeHg), a powerful neurotoxin that threatens humans and wildlife. Here, we report total Hg (THg) concentrations in body feathers from 516 individual albatrosses from 35 populations, including all 20 taxa breeding in the Southern Ocean. Our key finding is that albatrosses constitute the family of birds with the highest levels of contamination by Hg, with mean feather THg concentrations in different populations ranging from moderate (3...
May 23, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29801011/effect-of-intravesical-instillation-of-gemcitabine-vs-saline-immediately-following-resection-of-suspected-low-grade-non-muscle-invasive-bladder-cancer-on-tumor-recurrence-swog-s0337-randomized-clinical-trial
#13
RANDOMIZED CONTROLLED TRIAL
Edward M Messing, Catherine M Tangen, Seth P Lerner, Deepak M Sahasrabudhe, Theresa M Koppie, David P Wood, Philip C Mack, Robert S Svatek, Christopher P Evans, Khaled S Hafez, Daniel J Culkin, Timothy C Brand, Lawrence I Karsh, Jeffrey M Holzbeierlein, Shandra S Wilson, Guan Wu, Melissa Plets, Nicholas J Vogelzang, Ian M Thompson
Importance: Low-grade non-muscle-invasive urothelial cancer frequently recurs after excision by transurethral resection of bladder tumor (TURBT). Objective: To determine whether immediate post-TURBT intravesical instillation of gemcitabine reduces recurrence of suspected low-grade non-muscle-invasive urothelial cancer compared with saline. Design, Setting, and Participants: Randomized double-blind clinical trial conducted at 23 US centers...
May 8, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29799823/trauma-hemostasis-and-oxygenation-research-network-position-paper-on-the-role-of-hypotensive-resuscitation-as-part-of-remote-damage-control-resuscitation
#14
Thomas Woolley, Patrick Thompson, Emrys Kirkman, Richard Reed, Sylvain Ausset, Andrew Beckett, Christopher Bjerkvig, Andrew P Cap, Tim Coats, Mitchell Cohen, Marc Despasquale, Warren Dorlac, Heidi Doughty, Richard Dutton, Brian Eastridge, Elon Glassberg, Anthony Hudson, Donald Jenkins, Sean Keenan, Christophe Martinaud, Ethan Miles, Ernest Moore, Giles Nordmann, Nicolas Prat, Joseph Rappold, Michael C Reade, Paul Rees, Rory Rickard, Martin Schreiber, Stacy Shackelford, Håkon Skogran Eliassen, Jason Smith, Mike Smith, Philip Spinella, Geir Strandenes, Kevin Ward, Sarah Watts, Nathan White, Steve Williams
The Trauma Hemostasis and Oxygenation Research (THOR) Network has developed a consensus statement on the role of permissive hypotension in remote damage control resuscitation (RDCR). A summary of the evidence on permissive hypotension follows the THOR Network position on the topic. In RDCR, the burden of time in the care of the patients suffering from noncompressible hemorrhage affects outcomes. Despite the lack of published evidence, and based on clinical experience and expertise, it is the THOR Network's opinion that the increase in prehospital time leads to an increased burden of shock, which poses a greater risk to the patient than the risk of rebleeding due to slightly increased blood pressure, especially when blood products are available as part of prehospital resuscitation...
June 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29787415/cooccurrence-of-post-intensive-care-syndrome-problems-among-406-survivors-of-critical-illness
#15
Annachiara Marra, Pratik P Pandharipande, Timothy D Girard, Mayur B Patel, Christopher G Hughes, James C Jackson, Jennifer L Thompson, Rameela Chandrasekhar, Eugene Wesley Ely, Nathan E Brummel
OBJECTIVES: To describe the frequency of cooccurring newly acquired cognitive impairment, disability in activities of daily livings, and depression among survivors of a critical illness and to evaluate predictors of being free of post-intensive care syndrome problems. DESIGN: Prospective cohort study. SETTING: Medical and surgical ICUs from five U.S. centers. PATIENTS: Patients with respiratory failure or shock, excluding those with preexisting cognitive impairment or disability in activities of daily livings...
May 21, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29775310/fragment-based-discovery-of-a-potent-orally-bioavailable-inhibitor-which-modulates-the-phosphorylation-and-catalytic-activity-of-erk1-2
#16
Tom D Heightman, Valerio Berdini, Hannah Braithwaite, Ildiko Maria Buck, Megan Cassidy, Juan Castro, Aurelie Courtin, James E H Day, Charlotte East, Lynsey Fazal, Brent Graham, Charlotte M Griffiths-Jones, John F Lyons, Vanessa Martins, Sandra Muench, Joanne M Munck, David Norton, Marc O'Reilly, Nick Palmer, Puja Pathuri, Michael Reader, David C Rees, Sharna J Rich, Caroline Richardson, Harpreet Saini, Neil T Thompson, Nicola G Wallis, Hugh Walton, Nicola E Wilsher, Alison J-A Woolford, Michael Cooke, David Cousin, Stuart Onions, Jonathan Shannon, John Watts, Christopher W Murray
Aberrant activation of the MAPK pathway drives cell proliferation in multiple cancers. Inhibitors of BRAF and MEK kinases are approved for the treatment of BRAF mutant melanoma, but resistance frequently emerges, often mediated by increased signalling through ERK1/2. Here we describe the fragment based generation of ERK1/2 inhibitors which block catalytic phosphorylation of downstream substrates such as RSK but also modulate phosphorylation of ERK1/2 by MEK without directly inhibiting MEK. X-ray crystallographic and biophysical fragment screening followed by structure-guided optimization and growth from the hinge into a pocket proximal to the C-α helix afforded highly potent ERK1/2 inhibitors with excellent kinome selectivity...
May 18, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29749094/magnetic-resonance-spectroscopy-of-fiber-tracts-in-children-with-traumatic-brain-injury-a-combined-mrs-diffusion-mri-study
#17
Emily L Dennis, Talin Babikian, Jeffry Alger, Faisal Rashid, Julio E Villalon-Reina, Yan Jin, Alexander Olsen, Richard Mink, Christopher Babbitt, Jeffrey Johnson, Christopher C Giza, Paul M Thompson, Robert F Asarnow
Traumatic brain injury can cause extensive damage to the white matter (WM) of the brain. These disruptions can be especially damaging in children, whose brains are still maturing. Diffusion magnetic resonance imaging (dMRI) is the most commonly used method to assess WM organization, but it has limited resolution to differentiate causes of WM disruption. Magnetic resonance spectroscopy (MRS) yields spectra showing the levels of neurometabolites that can indicate neuronal/axonal health, inflammation, membrane proliferation/turnover, and other cellular processes that are on-going post-injury...
May 10, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29720450/er-stress-in-prostate-cancer-a-therapeutically-exploitable-vulnerability
#18
REVIEW
Christopher Logothetis, Ana Aparicio, Timothy C Thompson
Cooperative oncogenic effects resulting from the loss of PTEN and overexpression of MYC overcome the deleterious effects of endoplasmic reticulum stress not only to promote the growth of aggressive prostate cancer but also to expose a new therapy target for this disease (Nguyen et al , this issue).
May 2, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29695609/bitopic-binding-mode-of-an-m-1-muscarinic-acetylcholine-receptor-agonist-associated-with-adverse-clinical-trial-outcomes
#19
Sophie J Bradley, Colin Molloy, Christoffer Bundgaard, Adrian J Mogg, Karen J Thompson, Louis Dwomoh, Helen E Sanger, Michael D Crabtree, Simon M Brooke, Patrick M Sexton, Christian C Felder, Arthur Christopoulos, Lisa M Broad, Andrew B Tobin, Christopher J Langmead
The realization of the therapeutic potential of targeting the M1 muscarinic acetylcholine receptor (mAChR) for the treatment of cognitive decline in Alzheimer's disease has prompted the discovery of M1 mAChR ligands showing efficacy in alleviating cognitive dysfunction in both rodents and humans. Among these is GSK1034702 (7-fluoro-5-methyl-3-[1-(oxan-4-yl)piperidin-4-yl]-1 H -benzimidazol-2-one), described previously as a potent M1 receptor allosteric agonist, which showed procognitive effects in rodents and improved immediate memory in a clinical nicotine withdrawal test but induced significant side effects...
June 2018: Molecular Pharmacology
https://www.readbyqxmd.com/read/29678867/effect-of-the-duodenal-jejunal-bypass-liner-on-glycemic-control-in-patients-with-type-2-diabetes-with-obesity-a-meta-analysis-with-secondary-analysis-on-weight-loss-and-hormonal-changes
#20
REVIEW
Pichamol Jirapinyo, Andrea V Haas, Christopher C Thompson
OBJECTIVE: Duodenal-jejunal bypass liner (DJBL) is an endoscopic device that may mimic small bowel mechanisms of Roux-en-Y gastric bypass (RYGB). Previous studies have demonstrated the efficacy of DJBL at inducing weight loss. We assessed the effect of DJBL on glycemic control in patients with type 2 diabetes (T2D) with obesity. RESEARCH DESIGN AND METHODS: Data sources included MEDLINE, EMBASE, and Web of Science through 1 July 2017. Included were published studies that assessed DJBL outcomes in obese T2D patients...
May 2018: Diabetes Care
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