keyword
https://read.qxmd.com/read/38536910/changes-in-an-enzyme-ensemble-during-catalysis-observed-by-high-resolution-xfel-crystallography
#1
JOURNAL ARTICLE
Nathan Smith, Medhanjali Dasgupta, David C Wych, Cole Dolamore, Raymond G Sierra, Stella Lisova, Darya Marchany-Rivera, Aina E Cohen, Sébastien Boutet, Mark S Hunter, Christopher Kupitz, Frédéric Poitevin, Frank R Moss, David W Mittan-Moreau, Aaron S Brewster, Nicholas K Sauter, Iris D Young, Alexander M Wolff, Virendra K Tiwari, Nivesh Kumar, David B Berkowitz, Ryan G Hadt, Michael C Thompson, Alec H Follmer, Michael E Wall, Mark A Wilson
Enzymes populate ensembles of structures necessary for catalysis that are difficult to experimentally characterize. We use time-resolved mix-and-inject serial crystallography at an x-ray free electron laser to observe catalysis in a designed mutant isocyanide hydratase (ICH) enzyme that enhances sampling of important minor conformations. The active site exists in a mixture of conformations, and formation of the thioimidate intermediate selects for catalytically competent substates. The influence of cysteine ionization on the ICH ensemble is validated by determining structures of the enzyme at multiple pH values...
March 29, 2024: Science Advances
https://read.qxmd.com/read/38533551/inhibitory-protein-protein-interactions-of-the-sirt1-deacetylase-are-choreographed-by-post-translational-modification
#2
JOURNAL ARTICLE
Troy C Krzysiak, You-Jin Choi, Yong Joon Kim, Yunhan Yang, Christopher DeHaven, Lariah Thompson, Ryan Ponticelli, Mara M Mermigos, Laurel Thomas, Andrea Marquez, Ian Sipula, Jongsook Kim Kemper, Michael Jurczak, Gary Thomas, Angela M Gronenborn
Regulation of SIRT1 activity is vital to energy homeostasis and plays important roles in many diseases. We previously showed that insulin triggers the epigenetic regulator DBC1 to prime SIRT1 for repression by the multifunctional trafficking protein PACS-2. Here, we show that liver DBC1/PACS-2 regulates the diurnal inhibition of SIRT1, which is critically important for insulin-dependent switch in fuel metabolism from fat to glucose oxidation. We present the x-ray structure of the DBC1 S1-like domain that binds SIRT1 and an NMR characterization of how the SIRT1 N-terminal region engages DBC1...
April 2024: Protein Science
https://read.qxmd.com/read/38527465/return-to-the-pre-injury-level-of-sport-after-anterior-cruciate-ligament-reconstruction-a-practical-review-with-medical-recommendations
#3
JOURNAL ARTICLE
Braidy S Solie, Luke V Tollefson, Christopher P Doney, Jeremy M J O'Keefe, Will C Thompson, Robert F LaPrade
Returning to sport after anterior cruciate ligament reconstruction (ACLR) can be a challenging and complex process for the athlete, with the rate of return to the pre-injury level of sport observed to be less than athlete expectations. Of the athletes that do return to sport (RTS), knee re-injury rates remain high, and multiple studies have observed impaired athletic performance upon RTS after ACLR as well as reduced playing time, productivity, and career lengths. To mitigate re-injury and improve RTS outcomes, multiple RTS after ACLR consensus statements/clinical practice guidelines have recommended objective RTS testing criteria to be met prior to medical clearance for unrestricted sports participation...
March 25, 2024: International Journal of Sports Medicine
https://read.qxmd.com/read/38520430/identifying-subgroups-of-youth-suicide-decedents-based-on-clinical-profiles-of-psychiatric-and-medical-diagnoses-a-latent-class-analysis
#4
JOURNAL ARTICLE
Amanda J Thompson, Christopher C Henrich, Danielle L Steelesmith, Jennifer Hughes, Donna Ruch, Jeffrey A Bridge, John V Campo, Cynthia A Fontanella
PURPOSE: To identify risk subgroups of youth suicide decedents using demographic and clinical psychiatric and medical diagnostic profiles to inform tailored youth suicide prevention efforts. METHODS: This study linked Ohio Medicaid and death certificate data for Medicaid enrolled youth aged 8-25 years who died by suicide between January 1, 2010, and December 31, 2020 (N = 511). Latent class analysis was used to identify distinct clinical risk subgroups. RESULTS: Three latent classes were identified...
March 21, 2024: Journal of Adolescent Health
https://read.qxmd.com/read/38516639/otterly-diverse-a-high-diversity-of-dracunculus-species-spirurida-dracunculoidea-in-north-american-river-otters-lontra-canadensis
#5
JOURNAL ARTICLE
Michael J Yabsley, Kayla B Garrett, Alec T Thompson, Erin K Box, Madeline R Giner, Ellen Haynes, Heather Barron, Renata M Schneider, Sarah M Coker, James C Beasley, Ernest J Borchert, Renn Tumlison, Allison Surf, Casey G Dukes, Colleen Olfenbuttel, Justin D Brown, Liandrie Swanepoel, Christopher A Cleveland
The genus Dracunculus contains numerous species of subcutaneous parasites of mammals and reptiles. In North America, there are at least three mammal-infecting species of Dracunculus . Reports of Dracunculus infections have been reported from river otters ( Lontra canadensis ) since the early 1900s; however, little is known about the species infecting otters or their ecology. Most reports of Dracunculus do not have a definitive species identified because females, the most common sex found due to their larger size and location in the extremities of the host, lack distinguishing morphological characteristics, and few studies have used molecular methods to confirm identifications...
April 2024: International Journal for Parasitology. Parasites and Wildlife
https://read.qxmd.com/read/38512644/combination-therapy-of-endoscopic-gastric-remodeling-with-glp-1ra-for-the-treatment-of-masld
#6
JOURNAL ARTICLE
Pichamol Jirapinyo, Aunchalee Jaroenlapnopparat, Stephen D Zucker, Christopher C Thompson
PURPOSE: The mainstay of treatment for metabolic dysfunction-associated steatotic liver disease (MASLD) is weight loss. Endoscopic gastric remodeling (EGR) and glucagon-like peptide-1 receptor agonist (GLP-1RA) are effective weight loss therapies. This study aims to assess the effect of combining EGR with GLP-1RA on liver-related outcomes and weight profile. MATERIALS AND METHODS: This is a retrospective study of a prospectively collected registry of patients with MASLD and compensated advanced chronic liver disease (cACLD) who underwent EGR...
March 21, 2024: Obesity Surgery
https://read.qxmd.com/read/38509364/adaptive-foraging-behaviours-in-the-horn-of-africa-during-toba-supereruption
#7
JOURNAL ARTICLE
John Kappelman, Lawrence C Todd, Christopher A Davis, Thure E Cerling, Mulugeta Feseha, Abebe Getahun, Racheal Johnsen, Marvin Kay, Gary A Kocurek, Brett A Nachman, Agazi Negash, Tewabe Negash, Kaedan O'Brien, Michael Pante, Minghua Ren, Eugene I Smith, Neil J Tabor, Dereje Tewabe, Hong Wang, Deming Yang, Solomon Yirga, Jordan W Crowell, Matthew F Fanuka, Teshager Habtie, Jayde N Hirniak, Carla Klehm, Natalia D Loewen, Sahleselasie Melaku, Sierra M Melton, Timothy S Myers, Sarah Millonig, Megan C Plummer, Keenan J Riordan, Nicholas A Rosenau, Anne Skinner, Abraham K Thompson, Lindsey M Trombetta, Adrienne Witzel, Ephrem Assefa, Maria Bodansky, Ayenachew A Desta, Christopher J Campisano, Daniel Dalmas, Connor Elliott, Metasebia Endalamaw, Nicholas J Ford, Frederick Foster, Tomas Getachew, Yibai Li Haney, Brittney H Ingram, Jonayah Jackson, Curtis W Marean, Sissi Mattox, Karla de la Cruz Medina, Gebretsadkan Mulubrhan, Keri Porter, Alexis Roberts, Perla Santillan, Alaric Sollenberger, Julia Sponholtz, Jessica Valdes, Lani Wyman, Meklit Yadeta, Sierra Yanny
Although modern humans left Africa multiple times over 100,000 years ago, those broadly ancestral to non-Africans dispersed less than 100,000 years ago1 . Most models hold that these events occurred through green corridors created during humid periods because arid intervals constrained population movements2 . Here we report an archaeological site-Shinfa-Metema 1, in the lowlands of northwest Ethiopia, with Youngest Toba Tuff cryptotephra dated to around 74,000 years ago-that provides early and rare evidence of intensive riverine-based foraging aided by the likely adoption of the bow and arrow...
March 20, 2024: Nature
https://read.qxmd.com/read/38496668/a-worldwide-enigma-study-on-epilepsy-related-gray-and-white-matter-compromise-across-the-adult-lifespan
#8
Judy Chen, Alexander Ngo, Raúl Rodríguez-Cruces, Jessica Royer, Maria Eugenia Caligiuri, Antonio Gambardella, Luis Concha, Simon S Keller, Fernando Cendes, Clarissa L Yasuda, Marina K M Alvim, Leonardo Bonilha, Ezequiel Gleichgerrcht, Niels K Focke, Barbara Kreilkamp, Martin Domin, Felix von Podewils, Soenke Langner, Christian Rummel, Roland Wiest, Pascal Martin, Raviteja Kotikalapudi, Benjamin Bender, Terence J O'Brien, Benjamin Sinclair, Lucy Vivash, Patrick Kwan, Patricia M Desmond, Elaine Lui, Gian Marco Duma, Paolo Bonanni, Alice Ballerini, Anna Elisabetta Vaudano, Stefano Meletti, Manuela Tondelli, Saud Alhusaini, Colin P Doherty, Gianpiero L Cavalleri, Norman Delanty, Reetta Kälviäinen, Graeme D Jackson, Magdalena Kowalczyk, Mario Mascalchi, Mira Semmelroch, Rhys H Thomas, Hamid Soltanian-Zadeh, Esmaeil Davoodi-Bojd, Junsong Zhang, Matteo Lenge, Renzo Guerrini, Emanuele Bartolini, Khalid Hamandi, Sonya Foley, Theodor Rüber, Tobias Bauer, Bernd Weber, Benoit Caldairou, Chantal Depondt, Julie Absil, Sarah J A Carr, Eugenio Abela, Mark P Richardson, Orrin Devinsky, Heath Pardoe, Mariasavina Severino, Pasquale Striano, Domenico Tortora, Erik Kaestner, Sean N Hatton, Donatello Arienzo, Sjoerd B Vos, Mina Ryten, Peter N Taylor, John S Duncan, Christopher D Whelan, Marian Galovic, Gavin P Winston, Sophia I Thomopoulos, Paul M Thompson, Sanjay M Sisodiya, Angelo Labate, Carrie R McDonald, Lorenzo Caciagli, Neda Bernasconi, Andrea Bernasconi, Sara Larivière, Dewi Schrader, Boris C Bernhardt
OBJECTIVES: Temporal lobe epilepsy (TLE) is commonly associated with mesiotemporal pathology and widespread alterations of grey and white matter structures. Evidence supports a progressive condition although the temporal evolution of TLE is poorly defined. This ENIGMA-Epilepsy study utilized multimodal magnetic resonance imaging (MRI) data to investigate structural alterations in TLE patients across the adult lifespan. We charted both grey and white matter changes and explored the covariance of age-related alterations in both compartments...
March 6, 2024: bioRxiv
https://read.qxmd.com/read/38470211/species-composition-of-culicoides-diptera-ceratopogonidae-in-the-ridge-and-valley-region-of-tennessee-usa
#9
JOURNAL ARTICLE
Emily E Doub, Stacey L Vigil, Alec T Thompson, Avery L Korns, Michael J Yabsley, Mark G Ruder, Christopher A Cleveland
Biting midges in the genus Culicoides Latreille (Diptera: Ceratopogonidae) are known to transmit many pathogens of veterinary and medical concern. Although much work has been done globally and in certain regions of North America, Culicoides spp. research in rural Appalachia is limited. To begin characterizing the distribution and community structure of Culicoides spp. in Appalachia, we surveyed 2 distinct sites in the Ridge and Valley ecoregion of northeastern Tennessee, USA, from April 2021-September 2021...
March 12, 2024: Journal of Medical Entomology
https://read.qxmd.com/read/38454086/correction-white-matter-diffusion-estimates-in-obsessive-compulsive-disorder-across-1653-individuals-machine-learning-findings-from-the-enigma-ocd-working-group
#10
Bo-Gyeom Kim, Gakyung Kim, Yoshinari Abe, Pino Alonso, Stephanie Ameis, Alan Anticevic, Paul D Arnold, Srinivas Balachander, Nerisa Banaj, Nuria Bargalló, Marcelo C Batistuzzo, Francesco Benedetti, Sara Bertolín, Jan Carl Beucke, Irene Bollettini, Silvia Brem, Brian P Brennan, Jan K Buitelaar, Rosa Calvo, Miguel Castelo-Branco, Yuqi Cheng, Ritu Bhusal Chhatkuli, Valentina Ciullo, Ana Coelho, Beatriz Couto, Sara Dallaspezia, Benjamin A Ely, Sónia Ferreira, Martine Fontaine, Jean-Paul Fouche, Rachael Grazioplene, Patricia Gruner, Kristen Hagen, Bjarne Hansen, Gregory L Hanna, Yoshiyuki Hirano, Marcelo Q Höxter, Morgan Hough, Hao Hu, Chaim Huyser, Toshikazu Ikuta, Neda Jahanshad, Anthony James, Fern Jaspers-Fayer, Selina Kasprzak, Norbert Kathmann, Christian Kaufmann, Minah Kim, Kathrin Koch, Gerd Kvale, Jun Soo Kwon, Luisa Lazaro, Junhee Lee, Christine Lochner, Jin Lu, Daniela Rodriguez Manrique, Ignacio Martínez-Zalacaín, Yoshitada Masuda, Koji Matsumoto, Maria Paula Maziero, Jose M Menchón, Luciano Minuzzi, Pedro Silva Moreira, Pedro Morgado, Janardhanan C Narayanaswamy, Jin Narumoto, Ana E Ortiz, Junko Ota, Jose C Pariente, Chris Perriello, Maria Picó-Pérez, Christopher Pittenger, Sara Poletti, Eva Real, Y C Janardhan Reddy, Daan van Rooij, Yuki Sakai, João Ricardo Sato, Cinto Segalas, Roseli G Shavitt, Zonglin Shen, Eiji Shimizu, Venkataram Shivakumar, Noam Soreni, Carles Soriano-Mas, Nuno Sousa, Mafalda Machado Sousa, Gianfranco Spalletta, Emily R Stern, S Evelyn Stewart, Philip R Szeszko, Rajat Thomas, Sophia I Thomopoulos, Daniela Vecchio, Ganesan Venkatasubramanian, Chris Vriend, Susanne Walitza, Zhen Wang, Anri Watanabe, Lidewij Wolters, Jian Xu, Kei Yamada, Je-Yeon Yun, Mojtaba Zarei, Qing Zhao, Xi Zhu, Paul M Thompson, Willem B Bruin, Guido A van Wingen, Federica Piras, Fabrizio Piras, Dan J Stein, Odile A van den Heuvel, Helen Blair Simpson, Rachel Marsh, Jiook Cha
No abstract text is available yet for this article.
March 7, 2024: Molecular Psychiatry
https://read.qxmd.com/read/38451304/accelerating-medicines-partnership%C3%A2-schizophrenia-amp%C3%A2-scz-rationale-and-study-design-of-the-largest-global-prospective-cohort-study-of-clinical-high-risk-for-psychosis
#11
JOURNAL ARTICLE
Cassandra M J Wannan, Barnaby Nelson, Jean Addington, Kelly Allott, Alan Anticevic, Celso Arango, Justin T Baker, Carrie E Bearden, Tashrif Billah, Sylvain Bouix, Matthew R Broome, Kate Buccilli, Kristin S Cadenhead, Monica E Calkins, Tyrone D Cannon, Guillermo Cecci, Eric Yu Hai Chen, Kang Ik K Cho, Jimmy Choi, Scott R Clark, Michael J Coleman, Philippe Conus, Cheryl M Corcoran, Barbara A Cornblatt, Covadonga M Diaz-Caneja, Dominic Dwyer, Bjørn H Ebdrup, Lauren M Ellman, Paolo Fusar-Poli, Liliana Galindo, Pablo A Gaspar, Carla Gerber, Louise Birkedal Glenthøj, Robert Glynn, Michael P Harms, Leslie E Horton, René S Kahn, Joseph Kambeitz, Lana Kambeitz-Ilankovic, John M Kane, Tina Kapur, Matcheri S Keshavan, Sung-Wan Kim, Nikolaos Koutsouleris, Marek Kubicki, Jun Soo Kwon, Kerstin Langbein, Kathryn E Lewandowski, Gregory A Light, Daniel Mamah, Patricia J Marcy, Daniel H Mathalon, Patrick D McGorry, Vijay A Mittal, Merete Nordentoft, Angela Nunez, Ofer Pasternak, Godfrey D Pearlson, Jesus Perez, Diana O Perkins, Albert R Powers, David R Roalf, Fred W Sabb, Jason Schiffman, Jai L Shah, Stefan Smesny, Jessica Spark, William S Stone, Gregory P Strauss, Zailyn Tamayo, John Torous, Rachel Upthegrove, Mark Vangel, Swapna Verma, Jijun Wang, Inge Winter-van Rossum, Daniel H Wolf, Phillip Wolff, Stephen J Wood, Alison R Yung, Carla Agurto, Mario Alvarez-Jimenez, Paul Amminger, Marco Armando, Ameneh Asgari-Targhi, John Cahill, Ricardo E Carrión, Eduardo Castro, Suheyla Cetin-Karayumak, M Mallar Chakravarty, Youngsun T Cho, David Cotter, Simon D'Alfonso, Michaela Ennis, Shreyas Fadnavis, Clara Fonteneau, Caroline Gao, Tina Gupta, Raquel E Gur, Ruben C Gur, Holly K Hamilton, Gil D Hoftman, Grace R Jacobs, Johanna Jarcho, Jie Lisa Ji, Christian G Kohler, Paris Alexandros Lalousis, Suzie Lavoie, Martin Lepage, Einat Liebenthal, Josh Mervis, Vishnu Murty, Spero C Nicholas, Lipeng Ning, Nora Penzel, Russell Poldrack, Pablo Polosecki, Danielle N Pratt, Rachel Rabin, Habiballah Rahimi Eichi, Yogesh Rathi, Avraham Reichenberg, Jenna Reinen, Jack Rogers, Bernalyn Ruiz-Yu, Isabelle Scott, Johanna Seitz-Holland, Vinod H Srihari, Agrima Srivastava, Andrew Thompson, Bruce I Turetsky, Barbara C Walsh, Thomas Whitford, Johanna T W Wigman, Beier Yao, Hok Pan Yuen, Uzair Ahmed, Andrew Jin Soo Byun, Yoonho Chung, Kim Do, Larry Hendricks, Kevin Huynh, Clark Jeffries, Erlend Lane, Carsten Langholm, Eric Lin, Valentina Mantua, Gennarina Santorelli, Kosha Ruparel, Eirini Zoupou, Tatiana Adasme, Lauren Addamo, Laura Adery, Munaza Ali, Andrea Auther, Samantha Aversa, Seon-Hwa Baek, Kelly Bates, Alyssa Bathery, Johanna M M Bayer, Rebecca Beedham, Zarina Bilgrami, Sonia Birch, Ilaria Bonoldi, Owen Borders, Renato Borgatti, Lisa Brown, Alejandro Bruna, Holly Carrington, Rolando I Castillo-Passi, Justine Chen, Nicholas Cheng, Ann Ee Ching, Chloe Clifford, Beau-Luke Colton, Pamela Contreras, Sebastián Corral, Stefano Damiani, Monica Done, Andrés Estradé, Brandon Asika Etuka, Melanie Formica, Rachel Furlan, Mia Geljic, Carmela Germano, Ruth Getachew, Mathias Goncalves, Anastasia Haidar, Jessica Hartmann, Anna Jo, Omar John, Sarah Kerins, Melissa Kerr, Irena Kesselring, Honey Kim, Nicholas Kim, Kyle Kinney, Marija Krcmar, Elana Kotler, Melanie Lafanechere, Clarice Lee, Joshua Llerena, Christopher Markiewicz, Priya Matnejl, Alejandro Maturana, Aissata Mavambu, Rocío Mayol-Troncoso, Amelia McDonnell, Alessia McGowan, Danielle McLaughlin, Rebecca McIlhenny, Brittany McQueen, Yohannes Mebrahtu, Martina Mensi, Christy Lai Ming Hui, Yi Nam Suen, Stephanie Ming Yin Wong, Neal Morrell, Mariam Omar, Alice Partridge, Christina Phassouliotis, Anna Pichiecchio, Pierluigi Politi, Christian Porter, Umberto Provenzani, Nicholas Prunier, Jasmine Raj, Susan Ray, Victoria Rayner, Manuel Reyes, Kate Reynolds, Sage Rush, Cesar Salinas, Jashmina Shetty, Callum Snowball, Sophie Tod, Gabriel Turra-Fariña, Daniela Valle, Simone Veale, Sarah Whitson, Alana Wickham, Sarah Youn, Francisco Zamorano, Elissa Zavaglia, Jamie Zinberg, Scott W Woods, Martha E Shenton
This article describes the rationale, aims, and methodology of the Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ). This is the largest international collaboration to date that will develop algorithms to predict trajectories and outcomes of individuals at clinical high risk (CHR) for psychosis and to advance the development and use of novel pharmacological interventions for CHR individuals. We present a description of the participating research networks and the data processing analysis and coordination center, their processes for data harmonization across 43 sites from 13 participating countries (recruitment across North America, Australia, Europe, Asia, and South America), data flow and quality assessment processes, data analyses, and the transfer of data to the National Institute of Mental Health (NIMH) Data Archive (NDA) for use by the research community...
March 7, 2024: Schizophrenia Bulletin
https://read.qxmd.com/read/38434252/post-intensive-cardiac-care-outpatient-long-term-outreach-clinic-piccolo-clinic-defining-health-care-needs-and-outcomes-among-coronary-care-unit-survivors
#12
JOURNAL ARTICLE
Christopher K Mason, Sara K Adie, Michael J Shea, Matthew C Konerman, Michael P Thomas, Jakob I McSparron, Theodore J Iwashyna, Hallie C Prescott, Andrea D Thompson
OBJECTIVE: Patients who survive critical illness endure complex physical and mental health conditions, referred to as post-intensive care syndrome (PICS). The University of Michigan's post-intensive cardiac care outpatient long-term outreach (PICCOLO) clinic is designed for patients recently admitted to the coronary care unit (CCU). The long-term goal of this clinic is to understand post-CCU patients' needs and design targeted interventions to reduce their morbidity and mortality post-discharge...
February 2024: American heart journal plus: cardiology research and practice
https://read.qxmd.com/read/38431106/endoscopic-ultrasound-guided-liver-palpation-as-a-screening-tool-for-advanced-fibrosis-and-cirrhosis-in-patients-with-suspected-metabolic-dysfunction-associated-steatotic-liver-disease-a-pilot-study
#13
JOURNAL ARTICLE
Thomas J Wang, Pichamol Jirapinyo, Raj Shah, Kimberly Schuster, Christopher C Thompson, David B Lautz, Laura Doyon, Kenneth Chang, Marvin Ryou
BACKGROUND AND AIMS: Endoscopic liver "palpation" can be performed by indenting the liver surface under endoscopic ultrasound (EUS). Indentation depth is measured with sonographic calipers. We hypothesize that fibrotic livers are more difficult to indent, and indentation can accurately predict liver fibrosis staging. We compared EUS-guided liver palpation to conventional screening modalities in patients with suspected metabolic dysfunction-associated steatotic liver disease (MASLD). METHODS: This was a cross-sectional pilot study...
February 29, 2024: Gastrointestinal Endoscopy
https://read.qxmd.com/read/38405049/optimizing-endoscopic-bypass-procedures
#14
JOURNAL ARTICLE
Christopher C Thompson
No abstract text is available yet for this article.
January 2024: Gastroenterology & Hepatology
https://read.qxmd.com/read/38383154/genotype-specific-spinal-cord-damage-in-spinocerebellar-ataxias-an-enigma-ataxia-study
#15
JOURNAL ARTICLE
Thiago Junqueira Ribeiro Rezende, Isaac Adanyaguh, Orlando G P Barsottini, Benjamin Bender, Fernando Cendes, Leo Coutinho, Andreas Deistung, Imis Dogan, Alexandra Durr, Juan Fernandez-Ruiz, Sophia L Göricke, Marina Grisoli, Carlos R Hernandez-Castillo, Christophe Lenglet, Caterina Mariotti, Alberto R M Martinez, Breno K Massuyama, Fanny Mochel, Lorenzo Nanetti, Anna Nigri, Sergio E Ono, Gülin Öz, José Luiz Pedroso, Kathrin Reetz, Matthis Synofzik, Helio Teive, Sophia I Thomopoulos, Paul M Thompson, Dagmar Timmann, Bart P C van de Warrenburg, Judith van Gaalen, Marcondes C França, Ian H Harding
BACKGROUND: Spinal cord damage is a feature of many spinocerebellar ataxias (SCAs), but well-powered in vivo studies are lacking and links with disease severity and progression remain unclear. Here we characterise cervical spinal cord morphometric abnormalities in SCA1, SCA2, SCA3 and SCA6 using a large multisite MRI dataset. METHODS: Upper spinal cord (vertebrae C1-C4) cross-sectional area (CSA) and eccentricity (flattening) were assessed using MRI data from nine sites within the ENIGMA-Ataxia consortium, including 364 people with ataxic SCA, 56 individuals with preataxic SCA and 394 nonataxic controls...
February 21, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/38380940/regional-practice-variation-and-outcomes-in-the-standard-versus-accelerated-initiation-of-renal-replacement-therapy-in-acute-kidney-injury-starrt-aki-trial-a-post-hoc-secondary-analysis
#16
JOURNAL ARTICLE
Suvi T Vaara, Ary Serpa Neto, Rinaldo Bellomo, Neill K J Adhikari, Didier Dreyfuss, Martin Gallagher, Stephane Gaudry, Eric Hoste, Michael Joannidis, Ville Pettilä, Amanda Y Wang, Kianoush Kashani, Ron Wald, Sean M Bagshaw, Marlies Ostermann, Sean M Bagshaw, Ron Wald, Neill K J Adhikari, Rinaldo Bellomo, Didier Dreyfuss, Bin Du, Martin P Gallagher, Stéphane Gaudry, Eric A Hoste, François Lamontagne, Michael Joannidis, Kathleen D Liu, Daniel F McAuley, Shay P McGuinness, Alistair D Nichol, Marlies Ostermann, Paul M Palevsky, Haibo Qiu, Ville Pettilä, Antoine G Schneider, Orla M Smith, Suvi T Vaara, Matthew Weir, Rinaldo Bellomo, Glenn M Eastwood, Leah Peck, Helen Young, Peter Kruger, Gordon Laurie, Emma Saylor, Jason Meyer, Ellen Venz, Krista Wetzig, Craig French, Forbes McGain, John Mulder, Gerard Fennessy, Sathyajith Koottayi, Samantha Bates, Miriam Towns, Rebecca Morgan, Anna Tippett, Andrew Udy, Chris Mason, Elisa Licari, Dashiell Gantner, Jason McClure, Alistair Nichol, Phoebe McCracken, Jasmin Board, Emma Martin, Shirley Vallance, Meredith Young, Chelsey Vladic, Steve McGloughlin, David Gattas, Heidi Buhr, Jennifer Coles, Debra Hutch, James Wun, Louise Cole, Christina Whitehead, Julie Lowrey, Kristy Masters, Rebecca Gresham, Victoria Campbell, David Gutierrez, Jane Brailsford, Loretta Forbes, Lauren Murray, Teena Maguire, Martina NiChonghaile, Neil Orford, Allison Bone, Tania Elderkin, Tania Salerno, Tim Chimunda, Jason Fletcher, Emma Broadfield, Sanjay Porwal, Cameron Knott, Catherine Boschert, Julie Smith, Angus Richardson, Dianne Hill, Graeme Duke, Peter Oziemski, Santiago Cegarra, Peter Chan, Deborah Welsh, Stephanie Hunter, Owen Roodenburg, John Dyett, Nicos Kokotsis, Max Moser, Yang Yang, Laven Padayachee, Joseph Vetro, Himangsu Gangopadhyay, Melissa Kaufman, Angaj Ghosh, Simone Said, Alpesh Patel, Shailesh Bihari, Elisha Matheson, Xia Jin, Tapaswi Shrestha, Kate Schwartz, Martin P Gallagher, Rosalba Cross, Winston Cheung, Helen Wong, Mark Kol, Asim Shah, Amanda Y Wang, Zoltan Endre, Celia Bradford, Pierre Janin, Simon Finfer, Naomi Diel, Jonathan Gatward, Naomi Hammond, Anthony Delaney, Frances Bass, Elizabeth Yarad, Hergen Buscher, Claire Reynolds, Nerilee Baker, Michael Joannidis, Romuald Bellmann, Andreas Peer, Julia Hasslacher, Paul Koglberger, Sebastian Klein, Klemens Zotter, Anna Brandtner, Armin Finkenstedt, Adelheid Ditlbacher, Frank Hartig, Dietmar Fries, Mirjam Bachler, Bettina Schenk, Martin Wagner, Thomas Staudinger, Esther Tiller, Peter Schellongowski, Andja Bojic, Eric A Hoste, Stephanie Bracke, Luc De Crop, Daisy Vermeiren, Fernando Thome, Bianca Chiella, Lucia Fendt, Veronica Antunes, Maisonneuve-Rosemont, Jean-Philippe Lafrance, François Lamontagne, Frédérick D'Aragon, Charles St-Arnaud, Michael Mayette, Élaine Carbonnaeu, Joannie Marchand, Marie-Hélène Masse, Marilène Ladouceur, Alexis F Turgeon, François Lauzier, David Bellemare, Charles Langis Francoeur, Guillaume LeBlanc, Gabrielle Guilbault, Stéphanie Grenier, Eve Cloutier, Annick Boivin, Charles Delisle-Thibault, Panagiota Giannakouros, Olivier Costerousse, Jean-François Cailhier, François-Martin Carrier, Ali Ghamraoui, Martine Lebrasseur, Fatna Benettaib, Maya Salamé, Dounia Boumahni, Ying Tung Sia, Jean-François Naud, Isabelle Roy, Henry T Stelfox, Stacey Ruddell, Braden J Manns, Shelley Duggan, Dominic Carney, Jennifer Barchard, Richard P Whitlock, Emilie Belley-Cote, Nevena Savija, Alexandra Sabev, Troy Campbell, Thais Creary, Kelson Devereaux, Shira Brodutch, Claudio Rigatto, Bojan Paunovic, Owen Mooney, Anna Glybina, Oksana Harasemiw, Michelle Di Nella, John Harmon, Navdeep Mehta, Louis Lakatos, Nicole Haslam, Francois Lellouche, Mathieu Simon, Ying Tung, Patricia Lizotte, Pierre-Alexandre Bourchard, Bram Rochwerg, Tim Karachi, Tina Millen, John Muscedere, David Maslove, J Gordon Boyd, Stephanie Sibley, John Drover, Miranda Hunt, Ilinca Georgescu, Randy Wax, Ilan Lenga, Kavita Sridhar, Andrew Steele, Kelly Fusco, Taneera Ghate, Michael Tolibas, Holly Robinson, Matthew A Weir, Ravi Taneja, Ian M Ball, Amit Garg, Eileen Campbell, Athena Ovsenek, Sean M Bagshaw, Sean van Diepen, Nadia Baig, Sheldon Magder, Han Yao, Ahsan Alam, Josie Campisi, Erika MacIntyre, Ella Rokosh, Kimberly Scherr, Stephen Lapinsky, Sangeeta Mehta, Sumesh Shah, Daniel J Niven, Henry T Stelfox, Stacey Ruddell, Michael Russell, Kym Jim, Gillian Brown, Kerry Oxtoby, Adam Hall, Luc Benoit, Colleen Sokolowski, Bhanu Prasad, Jag Rao, Shelley Giebel, Demetrios J Kutsogiannis, Patricia Thompson, Tayne Thompson, Robert Cirone, Kanthi Kavikondala, Mark Soth, France Clarke, Alyson Takaoka, Ron Wald, David Mazer, Karen Burns, Jan Friedrich, David Klein, Gyan Sandhu, Marlene Santos, Imrana Khalid, Jennifer Hodder, Peter Dodek, Najib Ayas, Victoria Alcuaz, Gabriel Suen, Oleksa Rewa, Gurmeet Singh, Sean Norris, Neil Gibson, Castro Arias, Aysha Shami, Celine Pelletier, Neill K J Adhikari, Alireza Zahirieh, Andre Amaral, Nicole Marinoff, Navjot Kaur, Adic Perez, Jane Wang, Gregory Haljan, Christopher Condin, Lauralyn McIntyre, Brigette Gomes, Rebecca Porteous, Irene Watpool, Swapnil Hiremath, Edward Clark, Margaret S Herridge, Felicity Backhouse, M Elizabeth Wilcox, Karolina Walczak, Vincent Ki, Asheer Sharman, Martin Romano, Sean M Bagshaw, R T Noel Gibney, Adam S Romanovsky, Oleksa Rewa, Lorena McCoshen, Nadia Baig, Gordon Wood, Daniel Ovakim, Fiona Auld, Gayle Carney, Meili Duan, Xiaojun Ji, Dongchen Guo, Zhili Qi, Jin Lin, Meng Zhang, Lei Dong, Jingfeng Liu, Pei Liu, Deyuan Zhi, Guoqiang Bai, Yu Qiu, Ziqi Yang, Jing Bai, Zhuang Liu, Haizhou Zhuang, Haiman Wang, Jian Li, Mengya Zhao, Xiao Zhou, Xianqing Shi, Baning Ye, Manli Liu, Jing Wu, Yongjian Fu, Dali Long, Yu Pan, Jinlong Wang, Huaxian Mei, Songsong Zhang, Mingxiang Wen, Enyu Yang, Sijie Mu, Jianquan Li, Tingting Hu, Bingyu Qin, Min Li, Cunzhen Wang, Xin Dong, Kaiwu Wang, Haibo Wang, Jianxu Yang, Bin Du, Chuanyao Wang, Dongxin Wang, Nan Li, Zhui Yu, Song Xu, Lan Yao, Guo Hou, Zhou Liu, Liping Lu, Yingtao Lian, Chunting Wang, Jichen Zhang, Ruiqi Ding, Guoqing Qi, Qizhi Wang, Peng Wang, Zhaoli Meng, Man Chen, Xiaobo Hu, Xiandi He, Shibing Zhao, Lele Hang, Rui Li, Suhui Qin, Kun Lu, Shijuan Dun, Cheng Liu, Qi Zhou, Zhenzhen Chen, Jing Mei, Minwei Zhang, Hao Xu, Jincan Lin, Qindong Shi, Lijuan Fu, Qinjing Zeng, Hongye Ma, Jinqi Yan, Lan Gao, Hongjuan Liu, Lei Zhang, Hao Li, Xiaona He, Jingqun Fan, Litao Guo, Yu Liu, Xue Wang, Jingjing Sun, Zhongmin Liu, Juan Yang, Lili Ding, Lulu Sheng, Xingang Liu, Jie Yan, Quihui Wang, Yifeng Wang, Dan Zhao, Shuangping Zhao, Chenghuan Hu, Jing Li, Fuxing Deng, Haibo Qiu, Yi Yang, Min Mo, Chun Pan, Changde Wu, Yingzi Huang, Lili Huang, Airan Liu, Ville Pettilä, Suvi T Vaara, Anna-Maija Korhonen, Sanna Törnblom, Sari Sutinen, Leena Pettilä, Jonna Heinonen, Eliria Lappi, Taria Suhonen, Sari Karlsson, Sanna Hoppu, Ville Jalkanen, Anne Kuitunen, Markus Levoranta, Jaakko Långsjö, Sanna Ristimäki, Kaisa Malila, Anna Wootten, Simo Varila, Mikko J Järvisalo, Outi Inkinen, Satu Kentala, Keijo Leivo, Paivi Haltia, Didier Dreyfuss, Jean-Damien Ricard, Jonathan Messika, Abirami Tiagarajah, Malo Emery, Aline Dechanet, Coralie Gernez, Damien Roux, Laurent Martin-Lefevre, Maud Fiancette, Isabelle Vinatier, Jean Claude Lacherade, Gwenhaël Colin, Christine Lebert, Marie-Ange Azais, Aihem Yehia, Caroline Pouplet, Matthieu Henry-Lagarrigue, Amélie Seguin, Laura Crosby, Julien Maizel, Dimitri Titeca-Beauport, Alain Combes, Ania Nieszkowska, Paul Masi, Alexandre Demoule, Julien Mayaux, Martin Dres, Elise Morawiec, Maxens Decalvele, Suela Demiri, Morgane Faure, Clémence Marios, Maxime Mallet, Marie Amélie Ordon, Laura Morizot, Marie Cantien, François Pousset, Stéphane Gaudry, Florent Poirson, Yves Cohen, Laurent Argaud, Martin Cour, Laurent Bitker, Marie Simon, Romain Hernu, Thomas Baudry, Sylvie De La Salle, Adrien Robine, Nicholas Sedillot, Xavier Tchenio, Camille Bouisse, Sylvie Roux, Davide Barbar, Rémi Trusson, Fabienne Tamion, Steven Grangé, Dorothée Carpentier, Guillaume Chevrel, Luis Ensenyat-Martin, Sophie Marque, Jean-Pierre Quenot, Pascal Andreu, Auguste Dargent, Audrey Large, Nicolas Chudeau, Mickael Landais, Benoit Derrien, Jean Christophe Callahan, Christophe Guitton, Charlène Le Moal, Alain Robert, Karim Asehnoune, Raphaël Cinotti, Nicolas Grillot, Dominique Demeure, Christophe Vinsonneau, Imen Rahmani, Mehdi Marzouk, Thibault Dekeyser, Caroline Sejourne, Mélanie Verlay, Fabienne Thevenin, Lucie Delecolle, Lens Didier Thevenin, Bertrand Souweine, Elisabeth Coupez, Mireille Adda, Jean-Pierre Eraldi, Antoine Marchalot, Nicolas De Prost, Armand Mekontso Dessap, Keyvan Razazi, Ferhat Meziani, Julie Boisrame-Helms, Raphael Clere-Jehl, Xavier Delabranche, Christine Kummerlen, Hamid Merdji, Alexandra Monnier, Yannick Rabouel, Hassene Rahmani, Hayat Allam, Samir Chenaf, Vincenta Franja, Bertrand Pons, Michel Carles, Frédéric Martino, Régine Richard, Benjamin Zuber, Guillaume Lacave, Karim Lakhal, Bertrand Rozec, Hoa Dang Van, Éric Boulet, René Dubos, Fouad Fadel, Cedric Cleophax, Nicolas Dufour, Caroline Grant, Marie Thuong, Jean Reignier, Emmanuel Canet, Laurent Nicolet, Thierry Boulain, Mai-Anh Nay, Dalila Benzekri, François Barbier, Anne Bretagnol, Toufik Kamel, Armelle Mathonnet, Grégoire Muller, Marie Skarzynski, Julie Rossi, Amandine Pradet, Sandra Dos Santos, Aurore Guery, Lucie Muller, Luis Felix, Julien Bohé, Guillaume Thiéry, Nadia Aissaoui, Damien Vimpere, Morgane Commeureuc, Jean-Luc Diehl, Emmanuel Guerot, Orfeas Liangos, Monika Wittig, Alexander Zarbock, Mira Küllmar, Thomas van Waegeningh, Nadine Rosenow, Alistair D Nichol, Kathy Brickell, Peter Doran, Patrick T Murray, Giovanni Landoni, Rosalba Lembo, Alberto Zangrillo, Giacomo Monti, Margherita Tozzi, Matteo Marzaroli, Gaetano Lombardi, Gianluca Paternoster, Michelangelo Vitiello, Shay McGuinness, Rachael Parke, Magdalena Butler, Eileen Gilder, Keri-Anne Cowdrey, Samantha Wallace, Jane Hallion, Melissa Woolett, Philippa Neal, Karina Duffy, Stephanie Long, Colin McArthur, Catherine Simmonds, Yan Chen, Rachael McConnochie, Lynette Newby, David Knight, Seton Henderson, Jan Mehrtens, Stacey Morgan, Anna Morris, Kymbalee Vander Hayden, Tara Burke, Matthew Bailey, Ross Freebairn, Lesley Chadwick, Penelope Park, Christine Rolls, Liz Thomas, Ulrike Buehner, Erin Williams, Jonathan Albrett, Simon Kirkham, Carolyn Jackson, Troy Browne, Jennifer Goodson, David Jackson, James Houghton, Owen Callender, Vicki Higson, Owen Keet, Clive Dominy, Paul Young, Anna Hunt, Harriet Judd, Cassie Lawrence, Shaanti Olatunji, Yvonne Robertson, Charlotte Latimer-Bell, Deborah Hendry, Agnes Mckay-Vucago, Nina Beehre, Eden Lesona, Leanlove Navarra, Chelsea Robinson, Ryan Jang, Andrea Junge, Bridget Lambert, Antoine G Schneider, Michel Thibault, Philippe Eckert, Sébastien Kissling, Erietta Polychronopoulos, Elettra Poli, Marco Altarelli, Madeleine Schnorf, Samia Abed Mallaird, Claudia Heidegger, Aurelie Perret, Philippe Montillier, Frederic Sangla, Seigenthaller Neils, Aude De Watteville, Mandeep-Kaur Phull, Aparna George, Nauman Hussain, Tatiana Pogreban, Steve Lobaz, Alison Daniels, Mishell Cunningham, Deborah Kerr, Alice Nicholson, Pradeep Shanmugasundaram, Judith Abrams, Katarina Manso, Geraldine Hambrook, Elizabeth McKerrow, Juvy Salva, Stephen Foulkes, Matthew Wise, Matt Morgan, Jenny Brooks, Jade Cole, Tracy Michelle Davies, Helen Hill, Emma Thomas, Marcela Vizcaychipi, Behrad Baharlo, Jaime Carungcong, Patricia Costa, Laura Martins, Ritoo Kapoor, Tracy Hazelton, Angela Moon, Janine Musselwhite, Ben Shelley, Philip McCall, Marlies Ostermann, Gill Arbane, Aneta Bociek, Martina Marotti, Rosario Lim, Sara Campos, Neus Grau Novellas, Armando Cennamo, Andrew Slack, Duncan Wyncoll, Luigi Camporota, Simon Sparkes, Rosalinde Tilley, Austin Rattray, Gayle Moreland, Jane Duffy, Elizabeth McGonigal, Philip Hopkins, Clare Finney, John Smith, Harriet Noble, Hayley Watson, Claire-Louise Harris, Emma Clarey, Eleanor Corcoran, James Beck, Clare Howcroft, Nora Youngs, Elizabeth Wilby, Bethan Ogg, Adam Wolverson, Sandra Lee, Susie Butler, Maryanne Okubanjo, Julia Hindle, Ingeborg Welters, Karen Williams, Emily Johnson, Julie Patrick-Heselton, David Shaw, Victoria Waugh, Richard Stewart, Esther Mwaura, Lynn Wren, Louise Mew, Sara-Beth Sutherland, Jane Adderley, Jim Ruddy, Margaret Harkins, Callum Kaye, Teresa Scott, Wendy Mitchell, Felicity Anderson, Fiona Willox, Vijay Jagannathan, Michele Clark, Sarah Purv, Andrew Sharman, Megan Meredith, Lucy Ryan, Louise Conner, Cecilia Peters, Dan Harvey, Ashraf Roshdy, Amy Collins, Malcolm Sim, Steven Henderson, Nigel Chee, Sally Pitts, Katie Bowman, Maria Dilawershah, Luke Vamplew, Elizabeth Howe, Paula Rogers, Clara Hernandez, Clara Prendergast, Jane Benton, Alex Rosenberg, Lui G Forni, Alice Grant, Paula Carvelli, Ajay Raithatha, Sarah Bird, Max Richardson, Matthew Needham, Claire Hirst, Jonathan Ball, Susannah Leaver, Luisa Howlett, Carlos Castro Delgado, Sarah Farnell-Ward, Helen Farrah, Geraldine Gray, Gipsy Joseph, Francesca Robinson, Ascanio Tridente, Clare Harrop, Karen Shuker, Derek McLaughlan, Judith Ramsey, Sharon Meehan, Bernd Oliver Rose, Rosie Reece-Anthony, Babita Gurung, Tony Whitehouse, Catherine Snelson, Tonny Veenith, Andy Johnston, Lauren Cooper, Ron Carrera, Karen Ellis, Emma Fellows, Samanth Harkett, Colin Bergin, Elaine Spruce, Liesl Despy, Stephanie Goundry, Natalie Dooley, Tracy Mason, Amy Clark, Gemma Dignam, Geraldine Ward, Ben Attwood, Penny Parsons, Sophie Mason, Michael Margarson, Jenny Lord, Philip McGlone, Luke E Hodgson, Indra Chadbourn, Raquel Gomez, Jordi Margalef, Rinus Pretorius, Alexandra Hamshere, Joseph Carter, Hazel Cahill, Lia Grainger, Kate Howard, Greg Forshaw, Zoe Guy, Kianoush B Kashani, Robert C Albright, Amy Amsbaugh, Anita Stoltenberg, Alexander S Niven, Matthew Lynch, AnnMarie O'Mara, Syed Naeem, Sairah Sharif, Joyce McKenney Goulart, Matthew Lynch, AnnMarie O'Mara, Syed Naeem, Sairah Sharif, Joyce McKenney Goulart, Ashita Tolwani, Claretha Lyas, Laura Latta, Azra Bihorac, Haleh Hashemighouchani, Philip Efron, Matthew Ruppert, Julie Cupka, Sean Kiley, Joshua Carson, Peggy White, George Omalay, Sherry Brown, Laura Velez, Alina Marceron, Javier A Neyra, Juan Carlos Aycinena, Madona Elias, Victor M Ortiz-Soriano, Caroline Hauschild, Robert Dorfman
OBJECTIVES: Among patients with severe acute kidney injury (AKI) admitted to the ICU in high-income countries, regional practice variations for fluid balance (FB) management, timing, and choice of renal replacement therapy (RRT) modality may be significant. DESIGN: Secondary post hoc analysis of the STandard vs. Accelerated initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial (ClinicalTrials.gov number NCT02568722). SETTING: One hundred-fifty-three ICUs in 13 countries...
February 2024: Critical care explorations
https://read.qxmd.com/read/38366132/herbivore-effects-increase-with-latitude-across-the-extent-of-a-foundational-seagrass
#17
JOURNAL ARTICLE
Justin E Campbell, O Kennedy Rhoades, Calvin J Munson, Andrew H Altieri, James G Douglass, Kenneth L Heck, Valerie J Paul, Anna R Armitage, Savanna C Barry, Enrique Bethel, Lindsey Christ, Marjolijn J A Christianen, Grace Dodillet, Katrina Dutton, James W Fourqurean, Thomas K Frazer, Bethany M Gaffey, Rachael Glazner, Janelle A Goeke, Rancel Grana-Valdes, Victoria J Jenkins, Olivier A A Kramer, Samantha T Linhardt, Charles W Martin, Isis G Martinez Lopez, Ashley M McDonald, Vivienne A Main, Sarah A Manuel, Candela Marco-Méndez, Duncan A O'Brien, Owen R O'Shea, Christopher J Patrick, Clare Peabody, Laura K Reynolds, Alex Rodriguez, Lucia M Rodriguez Bravo, Amanda Sang, Yvonne Sawall, Khalil Smith, Fee O H Smulders, Uriah Sun, Jamie E Thompson, Brigitta van Tussenbroek, William L Wied
Climate change is altering the functioning of foundational ecosystems. While the direct effects of warming are expected to influence individual species, the indirect effects of warming on species interactions remain poorly understood. In marine systems, as tropical herbivores undergo poleward range expansion, they may change food web structure and alter the functioning of key habitats. While this process ('tropicalization') has been documented within declining kelp forests, we have a limited understanding of how this process might unfold across other systems...
February 16, 2024: Nature Ecology & Evolution
https://read.qxmd.com/read/38355210/isolated-left-sternocleidomastoid-pyomyositis-a-rare-presentation-of-cervical-sepsis
#18
JOURNAL ARTICLE
Calum Fraser, Christopher Sg Thompson, Justin C L Yeo
An elderly gentleman self-presented to A+E with a 7-day history of significant and progressive left-sided neck pain, swelling and fevers, despite oral antibiotics from his general practitioner. Examination revealed a large left-sided neck mass involving levels 2-5 of the neck that was firm to palpate, with erythematous overlying skin.An urgent CT scan demonstrated a large collection throughout the length of the left sternocleidomastoid muscle (SCM), measuring 13×5.5×4 cm, with extensive adjacent inflammatory change...
February 14, 2024: BMJ Case Reports
https://read.qxmd.com/read/38349361/muscle-fiber-cross-sectional-area-is-associated-with-quadriceps-strength-and-rate-of-torque-development-after-acl-injury
#19
JOURNAL ARTICLE
Megan C Graham, Katherine L Thompson, Gregory S Hawk, Christopher S Fry, Brian Noehren
Graham, MC, Thompson, KL, Hawk, GS, Fry, CS, and Noehren, B. Muscle fiber cross-sectional area is associated with quadriceps strength and rate of torque development after ACL injury. J Strength Cond Res XX(X): 000-000, 2023-The purpose of this study was to investigate the relationship between muscle fiber type-specific properties of the vastus lateralis and quadriceps muscle performance in individuals after an anterior cruciate ligament (ACL) tear. 26 subjects (22.0 ± 5.4 years) were included in this cross-sectional study, and all data were collected before ACL reconstruction...
February 13, 2024: Journal of Strength and Conditioning Research
https://read.qxmd.com/read/38345397/high-specificity-crispr-mediated-genome-engineering-in-anti-bcma-allogeneic-car-t-cells-suppresses-allograft-rejection-in-preclinical-models
#20
JOURNAL ARTICLE
Émilie Degagné, Paul D Donohoue, Suparna Roy, Jessica Scherer, Tristan W Fowler, Ryan T Davis, Gustavo A Reyes, George Kwong, Morena Stanaway, Vanina Larroca Vicena, Devin Mutha, Raymond Guo, Leslie Edwards, Benjamin Schilling, McKay Shaw, Stephen C Smith, Bryan Kohrs, Heinrich J Kufeldt, Glen Churchward, Finey Ruan, David B Nyer, Kyle McSweeney, Matthew J Irby, Christopher K Fuller, Lynda Banh, Mckenzi S Toh, Matthew Thompson, Arthur L G Owen, Zili An, Scott Gradia, Justin Skoble, Mara Bryan, Elizabeth Garner, Steven B Kanner
Allogeneic chimeric antigen receptor (CAR) T-cell therapies hold the potential to overcome many of the challenges associated with patient-derived (autologous) CAR T cells. Key considerations in the development of allogeneic CAR T-cell therapies include prevention of GvHD and suppression of allograft rejection. Here we describe preclinical data supporting the ongoing first-in-human clinical study, the CaMMouflage trial (NCT05722418), evaluating CB-011 in patients with relapsed/refractory multiple myeloma. CB-011 is a hypoimmunogenic, allogeneic anti-B cell maturation antigen (BCMA) CAR T-cell therapy candidate...
February 9, 2024: Cancer Immunology Research
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