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"Christopher C Thompson"

Emily L Dennis, Talin Babikian, Christopher C Giza, Paul M Thompson, Robert F Asarnow
Traumatic brain injury (TBI) is a major public health issue around the world and can be especially devastating in children as TBI can derail cognitive and social development. White matter (WM) is particularly vulnerable to disruption post-TBI, as myelination is ongoing during this period. Diffusion magnetic resonance imaging (dMRI) is a versatile modality for identifying and quantifying WM disruption and can detect diffuse axonal injury (DAI or TAI (traumatic axonal injury)). This review covers dMRI studies of pediatric TBI, including mild to severe injuries, and covering all periods post-injury...
October 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
Emily L Dennis, Faisal Rashid, Monica U Ellis, Talin Babikian, Roza M Vlasova, Julio E Villalon-Reina, Yan Jin, Alexander Olsen, Richard Mink, Christopher Babbitt, Jeffrey Johnson, Christopher C Giza, Paul M Thompson, Robert F Asarnow
OBJECTIVE: To examine longitudinal trajectories of white matter organization in pediatric moderate/severe traumatic brain injury (msTBI) over a 12-month period. METHODS: We studied 21 children (16 M/5 F) with msTBI, assessed 2-5 months postinjury and again 13-19 months postinjury, as well as 20 well-matched healthy control children. We assessed corpus callosum function through interhemispheric transfer time (IHTT), measured using event-related potentials, and related this to diffusion-weighted MRI measures of white matter (WM) microstructure...
April 11, 2017: Neurology
Emily L Dennis, Xue Hua, Julio Villalon-Reina, Lisa M Moran, Claudia Kernan, Talin Babikian, Richard Mink, Christopher Babbitt, Jeffrey Johnson, Christopher C Giza, Paul M Thompson, Robert F Asarnow
Traumatic brain injury (TBI) can cause widespread and prolonged brain degeneration. TBI can affect cognitive function and brain integrity for many years after injury, often with lasting effects in children, whose brains are still immature. Although TBI varies in how it affects different individuals, image analysis methods such as tensor-based morphometry (TBM) can reveal common areas of brain atrophy on magnetic resonance imaging (MRI), secondary effects of the initial injury, which will differ between subjects...
May 1, 2016: Journal of Neurotrauma
Emily L Dennis, Monica U Ellis, Sarah D Marion, Yan Jin, Lisa Moran, Alexander Olsen, Claudia Kernan, Talin Babikian, Richard Mink, Christopher Babbitt, Jeffrey Johnson, Christopher C Giza, Paul M Thompson, Robert F Asarnow
UNLABELLED: Traumatic brain injury (TBI) often results in traumatic axonal injury and white matter (WM) damage, particularly to the corpus callosum (CC). Damage to the CC can lead to impaired performance on neurocognitive tasks, but there is a high degree of heterogeneity in impairment following TBI. Here we examined the relation between CC microstructure and function in pediatric TBI. We used high angular resolution diffusion-weighted imaging (DWI) to evaluate the structural integrity of the CC in humans following brain injury in a sample of 32 children (23 males and 9 females) with moderate-to-severe TBI (msTBI) at 1-5 months postinjury, compared with well matched healthy control children...
July 15, 2015: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Emily L Dennis, Yan Jin, Julio E Villalon-Reina, Liang Zhan, Claudia L Kernan, Talin Babikian, Richard B Mink, Christopher J Babbitt, Jeffrey L Johnson, Christopher C Giza, Paul M Thompson, Robert F Asarnow
Traumatic brain injury (TBI) is the leading cause of death and disability in children and can lead to a wide range of impairments. Brain imaging methods such as DTI (diffusion tensor imaging) are uniquely sensitive to the white matter (WM) damage that is common in TBI. However, higher-level analyses using tractography are complicated by the damage and decreased FA (fractional anisotropy) characteristic of TBI, which can result in premature tract endings. We used the newly developed autoMATE (automated multi-atlas tract extraction) method to identify differences in WM integrity...
2015: NeuroImage: Clinical
Simion I Chiosea, Lindsay Williams, Christopher C Griffith, Lester D R Thompson, Ilan Weinreb, Julie E Bauman, Alyssa Luvison, Somak Roy, Raja R Seethala, Marina N Nikiforova
Contemporary classification and treatment of salivary duct carcinoma (SDC) require its thorough molecular characterization. Thirty apocrine SDCs were analyzed by the Ion Ampliseq Cancer HotSpot panel v2 for mutations in 50 cancer-related genes. Mutational findings were corroborated by immunohistochemistry (eg, TP53, BRAF, β-catenin, estrogen, and androgen receptors) or Sanger sequencing/SNaPshot polymerase chain reaction. ERBB2 (HER2), PTEN, FGFR1, CDKN2A/P16, CMET, EGFR, MDM2, and PIK3CA copy number changes were studied by fluorescence in situ hybridization...
June 2015: American Journal of Surgical Pathology
Christopher C Griffith, Lester D R Thompson, Adel Assaad, Bibianna M Purgina, Chi Lai, Julie E Bauman, Ilan Weinreb, Raja R Seethala, Simion I Chiosea
AIMS: The data on the histological type of carcinomatous component and the extent of extracapsular invasion for salivary carcinomas ex pleomorphic adenoma (PA) are conflicting. We aimed to determine the prognostic value of extracapsular invasion in salivary duct carcinomas (SDC) ex PA. METHODS AND RESULTS: A total of 117 patients with SDC were identified retrospectively; 44 cases involving major salivary glands had pre-existing PA (44 of 117, 37%). The morphological spectrum of SDC ex PA was characterized...
December 2014: Histopathology
Jonathon M Hall, Christopher C Parrish, Raymond J Thompson
No abstract text is available yet for this article.
June 2002: Biological Bulletin
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