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"Christopher Thompson"

George J Mak, Philipp Blanke, Kevin Ong, Christopher Naoum, Christopher R Thompson, John G Webb, Robert Moss, Robert Boone, Jian Ye, Anson Cheung, Brad Munt, Jonathon Leipsic, Jasmine Grewal
BACKGROUND: Previously, through the use of computed tomography (CT), it has been proposed that D-shaped versus saddle-shaped mitral annulus (MA) segmentation is more biomechanically appropriate to determine transcatheter mitral valve implantation size and eligibility. METHODS AND RESULTS: Forty-one patients with severe mitral regurgitation being considered for transcatheter mitral valve implantation who had undergone cardiac CT and 3-dimensional transesophageal echocardiography (3D-TEE) were retrospectively evaluated...
June 2016: Circulation. Cardiovascular Imaging
Emily A Ferenczi, Johannes Vierock, Kyoko Atsuta-Tsunoda, Satoshi P Tsunoda, Charu Ramakrishnan, Christopher Gorini, Kimberly Thompson, Soo Yeun Lee, Andre Berndt, Chelsey Perry, Sonja Minniberger, Arend Vogt, Joanna Mattis, Rohit Prakash, Scott Delp, Karl Deisseroth, Peter Hegemann
The extracellular ionic environment in neural tissue has the capacity to influence, and be influenced by, natural bouts of neural activity. We employed optogenetic approaches to control and investigate these interactions within and between cells, and across spatial scales. We began by developing a temporally precise means to study microdomain-scale interactions between extracellular protons and acid-sensing ion channels (ASICs). By coupling single-component proton-transporting optogenetic tools to ASICs to create two-component optogenetic constructs (TCOs), we found that acidification of the local extracellular membrane surface by a light-activated proton pump recruited a slow inward ASIC current, which required molecular proximity of the two components on the membrane...
2016: Scientific Reports
Miguel A D Neves, Christophe Blaszykowski, Michael Thompson
Aptasensing of small molecules remains a challenge as detection often requires the use of labels or signal amplification methodologies, resulting in both difficult-to-prepare sensor platforms and multistep, complex assays. Furthermore, many aptasensors rely on the binding mechanism or structural changes associated with target capture by the aptameric probe, resulting in a detection scheme customized to each aptamer. It is in this context that we report herein a sensitive cocaine aptasensor that offers both real-time and label-free measurement capabilities...
March 15, 2016: Analytical Chemistry
Jacob R Joseph, Nader Delavari, D Andrew Wilkinson, Christopher Roark, B Gregory Thompson
Hemiballismus is a rare presentation of symptomatic carotid stenosis that is underreported in the neurosurgical literature. It is characterized by severe, large amplitude movements that are classically caused by lesions of the subthalamic nucleus. Given the arterial border zone position of the subthalamic nucleus between the anterior and posterior circulation, hemodynamically compromising carotid stenosis can lead to hypoperfusion in this location. We describe the case of a patient who presented with acute-onset hemiballismus that had complete resolution of symptoms after carotid endarterectomy...
January 21, 2016: World Neurosurgery
Adriana Botero, Peta L Clode, Christopher Peacock, R C Andrew Thompson
Trypanosoma copemani has been found infecting several threatened/endangered marsupial species within Australia and is thought to be a key player in the rapid decline of the woylie (Bettongia penicillata). To better understand the biology and life cycle of this parasite, the growth requirements, and kinetics of infection of two newly described genotypes, T. copemani G1 and G2, were investigated and compared with the T. cruzi strain-10R26 in vitro. Both G1 and G2 were able to infect all four cell lines tested...
February 2016: Protist
Peter Rieckmann, Alexey Boyko, Diego Centonze, Irina Elovaara, Gavin Giovannoni, Eva Havrdová, Otto Hommes, Jurg Kesselring, Gisela Kobelt, Dawn Langdon, Jacques LeLorier, Sarah A Morrow, Celia Oreja-Guevara, Sven Schippling, Christoph Thalheim, Heidi Thompson, Patrick Vermersch
While advances in medicine, technology and healthcare services offer promises of longevity and improved quality of life (QoL), there is also increasing reliance on a patient׳s skills and motivation to optimize all the benefits available. Patient engagement in their own healthcare has been described as the 'blockbuster drug of the century'. In multiple sclerosis (MS), patient engagement is vital if outcomes for the patient, society and healthcare systems are to be optimized. The MS in the 21st Century Steering Group devised a set of themes that require action with regard to patient engagement in MS, namely: 1) setting and facilitating engagement by education and confidence-building; 2) increasing the importance placed on QoL and patient concerns through patient-reported outcomes (PROs); 3) providing credible sources of accurate information; 4) encouraging treatment adherence through engagement; and 5) empowering through a sense of responsibility...
May 2015: Multiple Sclerosis and related Disorders
Christopher Edge, Dean Thompson, Chunyan Hao, Jeff Houlahan
Herbicides and fertilizers are widely used throughout the world and pose a threat to aquatic ecosystems. Using a replicated, whole ecosystem experiment in which 24 small wetlands were split in half with an impermeable barrier we tested whether exposure to a glyphosate-based herbicide, Roundup WeatherMax™, alone or in combination with nutrient enrichment has an effect on the survival, growth or development of amphibians. The herbicide was applied at one of two concentrations (low=210 μg a.e./L, high=2880 μg a...
November 2014: Ecotoxicology and Environmental Safety
Jimmy Tiong, Andrew Gray, Christopher Jackson, Mark Thompson-Fawcett, Michael Schultz
BACKGROUND: Colorectal cancer is one of the most incident cancers in New Zealand. Due to resource limitations, some patients experienced protracted wait times before reaching a definitive diagnosis. We analysed the relationship between time to diagnosis and clinical stage and reviewed the length of time for components of the diagnostic work-up to identify priority areas for service improvement. We benchmarked our timeliness against introduced standards. METHODS: This retrospective study included all patients with colonic (not rectal) cancer between October 2007 and September 2009...
August 4, 2014: ANZ Journal of Surgery
Ruthanna Seidel, Christopher Carroll, Debra Thompson, Rena G Diem, Kwabena Yeboah, A J Hayes, Brett Hall, Harry T Whelan
Oxygen toxicity seizures are a rare but recognized complication of hyperbaric oxygen (HBO2) therapy. Many patients undergoing HBO2 therapy have medical conditions or are taking medications that could contribute to seizures. Previous literature has not extensively reported on these factors in patients experiencing oxygen toxicity seizures. We conducted a chart review at several hyperbaric oxygen centers in the Milwaukee, Wisc., area to explore whether the patients who experienced seizures in the hyperbaric chamber had other medical comorbidities or were on medications which lowered their seizure threshold, thereby contributing to oxygen toxicity seizures...
November 2013: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
Bin Wang, Xiaohan Lai, Christopher Price, William R Thompson, Wen Li, Tonima R Quabili, Wei-Ju Tseng, Xiaowei Sherry Liu, Hong Zhang, Jun Pan, Catherine B Kirn-Safran, Mary C Farach-Carson, Liyun Wang
The pericellular matrix (PCM), a thin coating surrounding nearly all mammalian cells, plays a critical role in many cell-surface phenomena. In osteocytes, the PCM is believed to control both "outside-in" (mechanosensing) and "inside-out" (signaling molecule transport) processes. However, the osteocytic PCM is challenging to study in situ because it is thin (∼100 nm) and enclosed in mineralized matrix. To this end, we recently developed a novel tracer velocimetry approach that combined fluorescence recovery after photobleaching (FRAP) imaging with hydrodynamic modeling to quantify the osteocytic PCM in young murine bone...
April 2014: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Lisa Prach, Ruth Koepke, Martin Kharrazi, Steven Keiles, Danieli B Salinas, Maria Carmen Reyes, Mark Pian, Harry Opsimos, Kimberly N Otsuka, Karen Ann Hardy, Carlos E Milla, Jacquelyn M Zirbes, Bradley Chipps, Susan O'Bra, Muhammad M Saeed, Reddivalam Sudhakar, Susan Lehto, Dennis Nielson, Gregory F Shay, Mary Seastrand, Sanjay Jhawar, Bruce Nickerson, Christopher Landon, Ann Thompson, Eliezer Nussbaum, Terry Chin, Henry Wojtczak
California uses a unique method to screen newborns for cystic fibrosis (CF) that includes gene scanning and DNA sequencing after only one California-40 cystic fibrosis transmembrane conductance regulator (CFTR) panel mutation has been identified in hypertrypsinogenemic specimens. Newborns found by sequencing to have one or more additional mutations or variants (including novel variants) in the CFTR gene are systematically followed, allowing for prospective assessment of the pathogenic potential of these variants...
September 2013: Journal of Molecular Diagnostics: JMD
Christopher Chapple, Karl-Dietrich Sievert, Scott MacDiarmid, Vik Khullar, Piotr Radziszewski, Christopher Nardo, Catherine Thompson, Jihao Zhou, Cornelia Haag-Molkenteller
BACKGROUND: Overactive bladder (OAB) syndrome with urinary incontinence (UI) is prevalent in the population and impairs health-related quality of life (HRQOL). OBJECTIVE: To assess the impact on efficacy, safety, and HRQOL of onabotulinumtoxinA (BOTOX(®), Allergan, Inc.) treatment in patients with OAB with UI. DESIGN, SETTING, AND PARTICIPANTS: This pivotal, multicentre, double-blind, randomised, placebo-controlled, phase 3 study enrolled patients with idiopathic OAB with ≥ 3 urgency UI episodes over 3 d and ≥ 8 micturitions per day who were inadequately managed by anticholinergics...
August 2013: European Urology
Val Shilling, Christopher Morris, Jo Thompson-Coon, Obioha Ukoumunne, Morwenna Rogers, Stuart Logan
AIM: To review the qualitative and quantitative evidence of the benefits of peer support for parents of children with disabling conditions in the context of health, well-being, impact on family, and economic and service implications. METHOD: We comprehensively searched multiple databases. Eligible studies evaluated parent-to-parent support and reported on the psychological health and experience of giving or receiving support. There were no limits on the child's condition, study design, language, date, or setting...
July 2013: Developmental Medicine and Child Neurology
Eric Rovner, Roger Dmochowski, Christopher Chapple, Catherine Thompson, Wayne Lam, Cornelia Haag-Molkenteller
AIMS: To evaluate the effect of onabotulinumtoxinA on urodynamic outcomes in patients with urinary incontinence (UI) due to neurogenic detrusor overactivity (NDO). METHODS: Results from two pivotal Phase III trials (n = 691) were pooled. MS or SCI patients with NDO, received intradetrusor onabotulinumtoxinA 200 U (n = 227), 300 U (n = 223), or placebo (n = 241). Change from baseline in UI episodes/week (Week 6), maximum cystometric capacity (MCC), maximum detrusor pressure at first involuntary detrusor contraction (IDC) (PdetmaxIDC), volume at first IDC (VpmaxIDC), and detrusor compliance (DC) were measured...
November 2013: Neurourology and Urodynamics
Ar Kar Aung, Bing Mei Teh, Christopher McGrath, Philip J Thompson
Pulmonary infections by Sporothrix spp. manifest radiologically as cavitary or non-cavitary disease depending on whether the infection is primary pulmonary or multifocal sporotrichosis. Despite current guidelines, the optimal management for pulmonary sporotrichosis remains unclear. In order to clarify this, we present two cases of pulmonary sporotrichosis, as well as the results of a comprehensive literature review of treatment outcomes based on clinico-radiological presentation patterns of the disease. A literature search of all case reports in English language over the last 50 years (1960-2010) was conducted...
July 2013: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
Christopher Carswell, Andrew Thompson, Ana Lukic, John Stevens, Peter Rudge, Simon Mead, John Collinge, Harpreet Hyare
BACKGROUND: Establishing a confident clinical diagnosis before an advanced stage of illness can be difficult in Creutzfeldt-Jakob disease (CJD) but unlike common causes of dementia, prion diseases can often be diagnosed by identifying characteristic MRI signal changes. However, it is not known how often CJD-associated MRI changes are identified at the initial imaging report, whether the most sensitive sequences are used, and what impact MRI-diagnosis has on prompt referral to clinical trial-like studies...
2012: BMC Neurology
Ceren Avci, Sonia Sheikh, Christophe Blaszykowski, Michael Thompson
The dynamics of serum adsorption on bare and monoethylene glycol adlayer-modified gold surfaces is investigated using acoustic wave physics. Hydration experiments support the pivotal role ascribed to water in the antifouling of surfaces. Behavioural discrepancy is interpreted in terms of difference in water structuring properties (surface kosmotropicity).
January 18, 2013: Chemical Communications: Chem Comm
Christopher Kobylecki, Jennifer C Thompson, Matthew Jones, Samantha J Mills, Sandip Shaunak, James W Ironside, Julie S Snowden, Anna M Richardson
Progressive non-fluent aphasia (PNFA) is typically associated with pathological changes consistent with frontotemporal lobar degeneration. A 65-year-old male presented with effortful speech, markedly impaired naming and features of speech apraxia, consistent with PNFA. Perceptuospatial function, calculation and executive function were intact. Brain SPECT showed left perisylvian hypoperfusion. He deteriorated profoundly over the subsequent eight months, with appearances on diffusion-weighted magnetic resonance imaging typical of sporadic Creutzfeldt-Jakob disease, which was confirmed pathologically at postmortem examination...
October 2013: Alzheimer Disease and Associated Disorders
Laura Eirmann, Christopher Cowell, Larry Thompson
Food safety is of concern for both human and companion animal health. Government agencies, pet food manufacturers, and veterinarians play crucial roles in ensuring the safety of pet food and safeguarding pets and their owners. Recent legislation will increase the governmental role in regulating pet food and will affect many manufacturers. Veterinarians continue to play a vital role by recognizing and reporting pet food safety issues and by educating clients on matters related to pet food safety.
January 2012: Compendium: Continuing Education for Veterinarians
Sonia Sheikh, David Yi Yang, Christophe Blaszykowski, Michael Thompson
Through systematic structural modification, it is shown that the internal, single oxygen atom of simple monoethylene glycol-based organic films is essential for radically altering the fouling behaviour of quartz against undiluted serum, as characterized by the electromagnetic piezoelectric acoustic sensor. The synergy is strongest with distal hydroxyls.
January 30, 2012: Chemical Communications: Chem Comm
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