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"Christopher Thompson"

William P Tormey
No abstract text is available yet for this article.
April 25, 2018: Irish Journal of Medical Science
Remco Hartkamp, Timothy C Moore, Christopher R Iacovella, Michael A Thompson, Pallav A Bulsara, David J Moore, Clare McCabe
The permeability of multicomponent phospholipid bilayers in the gel phase is investigated via molecular dynamics simulation. The physical role of the different molecules is probed by comparing multiple mixed-component bilayers containing distearylphosphatidylcholine (DSPC) with varying amounts of either the emollient isostearyl isostearate or long-chain alcohol (dodecanol, octadecanol, or tetracosanol) molecules. Permeability is found to depend on both the tail packing density and hydrogen bonding between lipid headgroups and water...
March 29, 2018: Journal of Physical Chemistry. B
Christopher Blackmore, Deborah Thompson, Johan Van Limbergen, Anthony Vandersteen, Rodrigo Romao
No abstract text is available yet for this article.
February 21, 2018: Journal of Pediatric Gastroenterology and Nutrition
Frances K Johnson, Jean-Christophe Delpech, Garth J Thompson, Lan Wei, Jin Hao, Peter Herman, Fahmeed Hyder, Arie Kaffman
Childhood maltreatment is associated with a wide range of psychopathologies including anxiety that emerge in childhood and in many cases persist in adulthood. Increased amygdala activation in response to threat and abnormal amygdala connectivity with frontolimbic brain regions, such as the hippocampus and the prefrontal cortex, are some of the most consistent findings seen in individuals exposed to childhood maltreatment. The underlying mechanisms responsible for these changes are difficult to study in humans but can be elucidated using animal models of early-life stress...
February 21, 2018: Translational Psychiatry
Peter Rieckmann, Diego Centonze, Irina Elovaara, Gavin Giovannoni, Eva Havrdová, Jurg Kesselring, Gisela Kobelt, Dawn Langdon, Sarah A Morrow, Celia Oreja-Guevara, Sven Schippling, Christoph Thalheim, Heidi Thompson, Patrick Vermersch, Karen Aston, Birgit Bauer, Christy Demory, Maria Paz Giambastiani, Jana Hlavacova, Jocelyne Nouvet-Gire, George Pepper, Maija Pontaga, Emma Rogan, Chrystal Rogalski, Pieter van Galen, Ali-Frédéric Ben-Amor
BACKGROUND: Patient engagement is vital in multiple sclerosis (MS) in order to optimise outcomes for patients, society and healthcare systems. It is essential to involve all stakeholders in potential solutions, working in a multidisciplinary way to ensure that people with MS (PwMS) are included in shared decision-making and disease management. To start this process, a collaborative, open environment between PwMS and healthcare professionals (HCPs) is required so that similarities and disparities in the perception of key areas in patient care and unmet needs can be identified...
January 2018: Multiple Sclerosis and related Disorders
Nicola Veronese, Ai Koyanagi, Brendon Stubbs, Marco Solmi, Michele Fornaro, Brisa S Fernandes, Christoph Muller, Trevor Thompson, André F Carvalho, Stefania Maggi
OBJECTIVE: Aspirin exhibits anti-atherosclerotic and anti-inflammatory properties-two potential risk factors for depression. The relationship between aspirin use and depression, however, remains unclear. We investigated whether the aspirin use is associated with a decreased incidence of depressive symptoms in a large North American cohort. METHODS: Data from the Osteoarthritis Initiative dataset, a multicenter, longitudinal study on community-dwelling adults was analyzed...
February 2018: International Journal of Geriatric Psychiatry
Beth A Taylor, Amanda L Zaleski, Kevin D Ballard, Gregory A Panza, Antonio B Fernandez, Lauren Corso, Linda S Pescatello, Aaron L Baggish, Christopher Troyanos, Paul D Thompson
OBJECTIVE: To investigate the effect of oral contraceptive (OC) use and compression socks on hemostatic activation in women flying cross-country to and from a marathon. DESIGN: Prospective study. SETTING: 2015 Boston Marathon. PARTICIPANTS: Women were divided into non-OC using (CONTROL; n = 12), OC-using (OC; n = 15), and OC-using plus compression sock (OC + SOCK; n = 14) groups. INTERVENTION: Women in OC + SOCK wore compression socks during flights to and from the marathon...
July 21, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
Madeleine R Geisheker, Gabriel Heymann, Tianyun Wang, Bradley P Coe, Tychele N Turner, Holly A F Stessman, Kendra Hoekzema, Malin Kvarnung, Marie Shaw, Kathryn Friend, Jan Liebelt, Christopher Barnett, Elizabeth M Thompson, Eric Haan, Hui Guo, Britt-Marie Anderlid, Ann Nordgren, Anna Lindstrand, Geert Vandeweyer, Antonino Alberti, Emanuela Avola, Mirella Vinci, Stefania Giusto, Tiziano Pramparo, Karen Pierce, Srinivasa Nalabolu, Jacob J Michaelson, Zdenek Sedlacek, Gijs W E Santen, Hilde Peeters, Hakon Hakonarson, Eric Courchesne, Corrado Romano, R Frank Kooy, Raphael A Bernier, Magnus Nordenskjöld, Jozef Gecz, Kun Xia, Larry S Zweifel, Evan E Eichler
Although de novo missense mutations have been predicted to account for more cases of autism than gene-truncating mutations, most research has focused on the latter. We identified the properties of de novo missense mutations in patients with neurodevelopmental disorders (NDDs) and highlight 35 genes with excess missense mutations. Additionally, 40 amino acid sites were recurrently mutated in 36 genes, and targeted sequencing of 20 sites in 17,688 patients with NDD identified 21 new patients with identical missense mutations...
August 2017: Nature Neuroscience
Stuart H Hershman, William A Kunkle, Michael P Kelly, Jacob M Buchowski, Wilson Z Ray, David B Bumpass, Jeffrey L Gum, Colleen M Peters, Weerasak Singhatanadgige, Jin Young Kim, Zachary A Smith, Wellington K Hsu, Ahmad Nassr, Bradford L Currier, Ra'Kerry K Rahman, Robert E Isaacs, Justin S Smith, Christopher Shaffrey, Sara E Thompson, Jeffrey C Wang, Elizabeth L Lord, Zorica Buser, Paul M Arnold, Michael G Fehlings, Thomas E Mroz, K Daniel Riew
STUDY DESIGN: Multicenter retrospective case series and review of the literature. OBJECTIVE: To determine the rate of esophageal perforations following anterior cervical spine surgery. METHODS: As part of an AOSpine series on rare complications, a retrospective cohort study was conducted among 21 high-volume surgical centers to identify esophageal perforations following anterior cervical spine surgery. Staff at each center abstracted data from patients' charts and created case report forms for each event identified...
April 2017: Global Spine Journal
David Eccleston, Mark Horrigan, Tony Rafter, Geoffrey Holt, Stephen G Worthley, Peter Sage, Alan Whelan, Christopher Reid, Peter L Thompson
BACKGROUND: Secondary prevention strategies after percutaneous coronary intervention (PCI) include statins and dual anti-platelet therapy, however there are significant gaps between guidelines and practice. Contemporary PCI practice requires comprehensive data collection to allow dynamic auditing and benchmarking of key performance and safety indices. Genesis HeartCare is Australia's largest collaborative venture of cardiologists, practising at over 40 public and private hospitals. We hypothesised that measurement and local reporting of data would improve patient outcomes through improving compliance with guideline therapies...
February 28, 2017: Heart, Lung & Circulation
Charles Mitz, Christopher Thome, Jeroen Thompson, Richard G Manzon, Joanna Y Wilson, Douglas R Boreham
We present a method to characterize variable thermal regimes in terms of an equivalent or effective temperature. Our method is based on a first order exponential transformation of a time series of temperatures to yield an exponentially-weighted mean temperature characteristic of the regime and independent of any particular species or end point. The resulting effective temperature or exponential mean, Te¯, offers an improved method for summarizing mean temperature where biological response scales exponentially to temperature...
April 2017: Journal of Thermal Biology
Adriana Botero, Sarah Keatley, Christopher Peacock, R C Andrew Thompson
Trypanosomes are blood protozoan parasites that are capable of producing illness in the vertebrate host. Within Australia, several native Trypanosoma species have been described infecting wildlife. However, only Trypanosoma copemani has been associated with pathological lesions in wildlife hosts and more recently has been associated with the drastic decline of the critically endangered woylie (Bettongia penicillata). The impact that some trypanosomes have on the health of the vertebrate host has led to the development of numerous drug compounds that could inhibit the growth or kill the parasite...
April 2017: International Journal for Parasitology, Drugs and Drug Resistance
George J Mak, Philipp Blanke, Kevin Ong, Christopher Naoum, Christopher R Thompson, John G Webb, Robert Moss, Robert Boone, Jian Ye, Anson Cheung, Brad Munt, Jonathon Leipsic, Jasmine Grewal
BACKGROUND: Previously, through the use of computed tomography (CT), it has been proposed that D-shaped versus saddle-shaped mitral annulus (MA) segmentation is more biomechanically appropriate to determine transcatheter mitral valve implantation size and eligibility. METHODS AND RESULTS: Forty-one patients with severe mitral regurgitation being considered for transcatheter mitral valve implantation who had undergone cardiac CT and 3-dimensional transesophageal echocardiography (3D-TEE) were retrospectively evaluated...
June 2016: Circulation. Cardiovascular Imaging
Emily A Ferenczi, Johannes Vierock, Kyoko Atsuta-Tsunoda, Satoshi P Tsunoda, Charu Ramakrishnan, Christopher Gorini, Kimberly Thompson, Soo Yeun Lee, Andre Berndt, Chelsey Perry, Sonja Minniberger, Arend Vogt, Joanna Mattis, Rohit Prakash, Scott Delp, Karl Deisseroth, Peter Hegemann
The extracellular ionic environment in neural tissue has the capacity to influence, and be influenced by, natural bouts of neural activity. We employed optogenetic approaches to control and investigate these interactions within and between cells, and across spatial scales. We began by developing a temporally precise means to study microdomain-scale interactions between extracellular protons and acid-sensing ion channels (ASICs). By coupling single-component proton-transporting optogenetic tools to ASICs to create two-component optogenetic constructs (TCOs), we found that acidification of the local extracellular membrane surface by a light-activated proton pump recruited a slow inward ASIC current, which required molecular proximity of the two components on the membrane...
April 5, 2016: Scientific Reports
Miguel A D Neves, Christophe Blaszykowski, Michael Thompson
Aptasensing of small molecules remains a challenge as detection often requires the use of labels or signal amplification methodologies, resulting in both difficult-to-prepare sensor platforms and multistep, complex assays. Furthermore, many aptasensors rely on the binding mechanism or structural changes associated with target capture by the aptameric probe, resulting in a detection scheme customized to each aptamer. It is in this context that we report herein a sensitive cocaine aptasensor that offers both real-time and label-free measurement capabilities...
March 15, 2016: Analytical Chemistry
Jacob R Joseph, Nader Delavari, D Andrew Wilkinson, Christopher Roark, B Gregory Thompson
BACKGROUND: Hemiballismus is a rare presentation of symptomatic carotid stenosis that is underreported in the neurosurgical literature. It is characterized by severe large-amplitude movements that are classically caused by lesions of the subthalamic nucleus. Given the arterial border zone position of the subthalamic nucleus between the anterior and posterior circulation, hemodynamically compromising carotid stenosis can lead to hypoperfusion in this location. CASE DESCRIPTION: We describe the case of a patient who presented with acute-onset hemiballismus that had complete resolution of symptoms after carotid endarterectomy...
November 2016: World Neurosurgery
Adriana Botero, Peta L Clode, Christopher Peacock, R C Andrew Thompson
Trypanosoma copemani has been found infecting several threatened/endangered marsupial species within Australia and is thought to be a key player in the rapid decline of the woylie (Bettongia penicillata). To better understand the biology and life cycle of this parasite, the growth requirements, and kinetics of infection of two newly described genotypes, T. copemani G1 and G2, were investigated and compared with the T. cruzi strain-10R26 in vitro. Both G1 and G2 were able to infect all four cell lines tested...
February 2016: Protist
Peter Rieckmann, Alexey Boyko, Diego Centonze, Irina Elovaara, Gavin Giovannoni, Eva Havrdová, Otto Hommes, Jurg Kesselring, Gisela Kobelt, Dawn Langdon, Jacques LeLorier, Sarah A Morrow, Celia Oreja-Guevara, Sven Schippling, Christoph Thalheim, Heidi Thompson, Patrick Vermersch
While advances in medicine, technology and healthcare services offer promises of longevity and improved quality of life (QoL), there is also increasing reliance on a patient׳s skills and motivation to optimize all the benefits available. Patient engagement in their own healthcare has been described as the 'blockbuster drug of the century'. In multiple sclerosis (MS), patient engagement is vital if outcomes for the patient, society and healthcare systems are to be optimized. The MS in the 21st Century Steering Group devised a set of themes that require action with regard to patient engagement in MS, namely: 1) setting and facilitating engagement by education and confidence-building; 2) increasing the importance placed on QoL and patient concerns through patient-reported outcomes (PROs); 3) providing credible sources of accurate information; 4) encouraging treatment adherence through engagement; and 5) empowering through a sense of responsibility...
May 2015: Multiple Sclerosis and related Disorders
Christopher Edge, Dean Thompson, Chunyan Hao, Jeff Houlahan
Herbicides and fertilizers are widely used throughout the world and pose a threat to aquatic ecosystems. Using a replicated, whole ecosystem experiment in which 24 small wetlands were split in half with an impermeable barrier we tested whether exposure to a glyphosate-based herbicide, Roundup WeatherMax™, alone or in combination with nutrient enrichment has an effect on the survival, growth or development of amphibians. The herbicide was applied at one of two concentrations (low=210 μg a.e./L, high=2880 μg a...
November 2014: Ecotoxicology and Environmental Safety
Jimmy Tiong, Andrew Gray, Christopher Jackson, Mark Thompson-Fawcett, Michael Schultz
BACKGROUND: Colorectal cancer is one of the most incident cancers in New Zealand. Due to resource limitations, some patients experienced protracted wait times before reaching a definitive diagnosis. We analysed the relationship between time to diagnosis and clinical stage and reviewed the length of time for components of the diagnostic work-up to identify priority areas for service improvement. We benchmarked our timeliness against introduced standards. METHODS: This retrospective study included all patients with colonic (not rectal) cancer between October 2007 and September 2009...
March 2017: ANZ Journal of Surgery
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