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Christopher C Thompson

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https://www.readbyqxmd.com/read/29220858/long-term-successful-closure-of-a-percutaneous-intragastric-trocar-tract-with-crossing-full-thickness-sutures-in-a-porcine-model
#1
Andrew C Storm, Hiroyuki Aihara, Matthew J Skinner, Marvin Ryou, Christopher C Thompson
Background and study aims A novel intragastric trocar placed using a percutaneous endoscopic gastrostomy technique enables the use of laparoscopic tools and procedures, including tissue stapling, cutting, suturing, and retraction. The aim of this porcine study was to determine long-term success of crossing full-thickness sutures in closure of the tract upon trocar withdrawal. Methods 10 trocars were placed in 5 animals. Each animal underwent a standardized tissue resection using a 5-mm stapler under gastroscopic guidance, and two full-thickness, absorbable, crossing sutures were used to close the trocar tracts...
December 8, 2017: Endoscopy
https://www.readbyqxmd.com/read/29214566/improved-diagnosis-and-care-for-rare-diseases-through-implementation-of-precision-public-health-framework
#2
Gareth Baynam, Faye Bowman, Karla Lister, Caroline E Walker, Nicholas Pachter, Jack Goldblatt, Kym M Boycott, William A Gahl, Kenjiro Kosaki, Takeya Adachi, Ken Ishii, Trinity Mahede, Fiona McKenzie, Sharron Townshend, Jennie Slee, Cathy Kiraly-Borri, Anand Vasudevan, Anne Hawkins, Stephanie Broley, Lyn Schofield, Hedwig Verhoef, Tudor Groza, Andreas Zankl, Peter N Robinson, Melissa Haendel, Michael Brudno, John S Mattick, Marcel E Dinger, Tony Roscioli, Mark J Cowley, Annie Olry, Marc Hanauer, Fowzan S Alkuraya, Domenica Taruscio, Manuel Posada de la Paz, Hanns Lochmüller, Kate Bushby, Rachel Thompson, Victoria Hedley, Paul Lasko, Kym Mina, John Beilby, Cynthia Tifft, Mark Davis, Nigel G Laing, Daria Julkowska, Yann Le Cam, Sharon F Terry, Petra Kaufmann, Iiro Eerola, Irene Norstedt, Ana Rath, Makoto Suematsu, Stephen C Groft, Christopher P Austin, Ruxandra Draghia-Akli, Tarun S Weeramanthri, Caron Molster, Hugh J S Dawkins
Public health relies on technologies to produce and analyse data, as well as effectively develop and implement policies and practices. An example is the public health practice of epidemiology, which relies on computational technology to monitor the health status of populations, identify disadvantaged or at risk population groups and thereby inform health policy and priority setting. Critical to achieving health improvements for the underserved population of people living with rare diseases is early diagnosis and best care...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29201280/a-network-approach-to-examining-injury-severity-in-pediatric-tbi
#3
Emily L Dennis, Faisal Rashid, Neda Jahanshad, Talin Babikian, Richard Mink, Christopher Babbitt, Jeffrey Johnson, Christopher C Giza, Robert F Asarnow, Paul M Thompson
Traumatic brain injury (TBI) is the leading cause of death and disability in children, and can lead to long lasting functional impairment. Many factors influence outcome, but imaging studies examining effects of individual variables are limited by sample size. Roughly 20-40% of hospitalized TBI patients experience seizures, but not all of these patients go on to develop a recurrent seizure disorder. Here we examined differences in structural network connectivity in pediatric patients who had sustained a moderate-severe TBI (msTBI)...
2017: Proceedings of the IEEE International Symposium on Biomedical Imaging: from Nano to Macro
https://www.readbyqxmd.com/read/29167563/specification-of-murine-ground-state-pluripotent-stem-cells-to-regional-neuronal-populations
#4
Walaa F Alsanie, Jonathan C Niclis, Cameron P Hunt, Isabelle R De Luzy, Vanessa Penna, Christopher R Bye, Colin W Pouton, John Haynes, Jaber Firas, Lachlan H Thompson, Clare L Parish
Pluripotent stem cells (PSCs) are a valuable tool for interrogating development, disease modelling, drug discovery and transplantation. Despite the burgeoned capability to fate restrict human PSCs to specific neural lineages, comparative protocols for mouse PSCs have not similarly advanced. Mouse protocols fail to recapitulate neural development, consequently yielding highly heterogeneous populations, yet mouse PSCs remain a valuable scientific tool as differentiation is rapid, cost effective and an extensive repertoire of transgenic lines provides an invaluable resource for understanding biology...
November 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29161989/comparison-of-toxicity-and-recovery-in-the-duodenum-of-b6c3f1-mice-following-treatment-with-intestinal-carcinogens-captan-folpet-and-hexavalent-chromium
#5
Chad M Thompson, Jeffrey C Wolf, Alene McCoy, Mina Suh, Deborah M Proctor, Christopher R Kirman, Laurie C Haws, Mark A Harris
High concentrations of hexavalent chromium (Cr(VI)), captan, and folpet induce duodenal tumors in mice. Using standardized tissue collection procedures and diagnostic criteria, we compared the duodenal histopathology in B6C3F1 mice following exposure to these 3 carcinogens to determine whether they share similar histopathological characteristics. B6C3F1 mice ( n = 20 per group) were exposed to 180 ppm Cr(VI) in drinking water, 12,000 ppm captan in feed, or 16,000 ppm folpet in feed for 28 days. After 28 days of exposure, villous enterocyte hypertrophy and mild crypt epithelial hyperplasia were observed in all exposed mice...
January 1, 2017: Toxicologic Pathology
https://www.readbyqxmd.com/read/29149383/diffusion-mri-in-pediatric-brain-injury
#6
Emily L Dennis, Talin Babikian, Christopher C Giza, Paul M Thompson, Robert F Asarnow
Traumatic brain injury (TBI) is a major public health issue around the world and can be especially devastating in children as TBI can derail cognitive and social development. White matter (WM) is particularly vulnerable to disruption post-TBI, as myelination is ongoing during this period. Diffusion magnetic resonance imaging (dMRI) is a versatile modality for identifying and quantifying WM disruption and can detect diffuse axonal injury (DAI or TAI (traumatic axonal injury)). This review covers dMRI studies of pediatric TBI, including mild to severe injuries, and covering all periods post-injury...
October 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29146842/genome-sequences-of-19-novel-erwinia-amylovora-bacteriophages
#7
Ian N D Esplin, Jordan A Berg, Ruchira Sharma, Robert C Allen, Daniel K Arens, Cody R Ashcroft, Shannon R Bairett, Nolan J Beatty, Madeline Bickmore, Travis J Bloomfield, T Scott Brady, Rachel N Bybee, John L Carter, Minsey C Choi, Steven Duncan, Christopher P Fajardo, Brayden B Foy, David A Fuhriman, Paul D Gibby, Savannah E Grossarth, Kala Harbaugh, Natalie Harris, Jared A Hilton, Emily Hurst, Jonathan R Hyde, Kayleigh Ingersoll, Caitlin M Jacobson, Brady D James, Todd M Jarvis, Daniella Jaen-Anieves, Garrett L Jensen, Bradley K Knabe, Jared L Kruger, Bryan D Merrill, Jenny A Pape, Ashley M Payne Anderson, David E Payne, Malia D Peck, Samuel V Pollock, Micah J Putnam, Ethan K Ransom, Devin B Ririe, David M Robinson, Spencer L Rogers, Kerri A Russell, Jonathan E Schoenhals, Christopher A Shurtleff, Austin R Simister, Hunter G Smith, Michael B Stephenson, Lyndsay A Staley, Jason M Stettler, Mallorie L Stratton, Olivia B Tateoka, P J Tatlow, Alexander S Taylor, Suzanne E Thompson, Michelle H Townsend, Trever L Thurgood, Brittian K Usher, Kiara V Whitley, Andrew T Ward, Megan E H Ward, Charles J Webb, Trevor M Wienclaw, Taryn L Williamson, Michael J Wells, Cole K Wright, Donald P Breakwell, Sandra Hope, Julianne H Grose
Erwinia amylovora is the causal agent of fire blight, a devastating disease affecting some plants of the Rosaceae family. We isolated bacteriophages from samples collected from infected apple and pear trees along the Wasatch Front in Utah. We announce 19 high-quality complete genome sequences of E. amylovora bacteriophages.
November 16, 2017: Genome Announcements
https://www.readbyqxmd.com/read/29139082/asge-endovators-summit-defining-the-role-and-value-of-endoscopic-therapies-in-obesity-management
#8
Marvin Ryou, Kenneth R McQuaid, Christopher C Thompson, Steven Edmundowic, Klaus Mergener
No abstract text is available yet for this article.
November 14, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29139029/asge-endovators-summit-defining-the-role-and-value-of-endoscopic-therapies-in-obesity-management
#9
Marvin Ryou, Kenneth R McQuaid, Christopher C Thompson, Steven Edmundowicz, Klaus Mergener
No abstract text is available yet for this article.
November 14, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29138927/asge-endovators-summit-defining-the-role-and-value-of-endoscopic-therapies-in-obesity-management
#10
Marvin Ryou, Kenneth R McQuaid, Christopher C Thompson, Steven Edmundowicz, Klaus Mergener
No abstract text is available yet for this article.
November 14, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29138344/targeting-the-mycn-parp-dna-damage-response-pathway-inneuroendocrine-prostate-cancer
#11
Wei Zhang, Bo Liu, Wenhui Wu, Likun Li, Bradley M Broom, Spyridon M Basourakos, Dimitrios Korentzelos, Yang Luan, Jianxiang Wang, Guang Yang, Sanghee Park, Abul K Azad, Xuhong Cao, Jeri Kim, Paul Corn, Christopher Logothetis, Ana M Aparicio, Arul M Chinnayan, Nora M Navone, Patricia Troncoso, Timothy C Thompson
PURPOSE: We investigated MYCN-regulated molecular pathways in castration-resistant prostate cancer (CRPC) classified by morphological criteria as adenocarcinoma or neuroendocrine to extend the molecular phenotype, establish driver pathways, and identify novel approaches to combination therapy for NEPC. RESULTS: Using comparative bioinformatics analyses of CRPC-Adeno and CRPC-Neuro RNA sequence data from public datasets and a panel of 28 PDX models we identified a MYCN-PARP-DNA damage response (DDR) pathway that is enriched in CRPC with neuroendocrine differentiation (NED) and CRPC-Neuro...
November 14, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29127551/endoscopic-evaluation-management-of-bariatric-surgery-complications
#12
REVIEW
Allison R Schulman, Christopher C Thompson
Purpose of Review Bariatric surgery has become increasingly common given the increasing prevalence of obesity and its associated co-morbidities. As a result, patients who have surgically altered anatomy will be seen with increasing frequency by gastroenterologists. Recent Findings Complications that arise in this patient population are unique and require specific knowledge for appropriate treatment. Summary A basic understanding of surgical anatomy, possible complications, and endoscopic techniques for management is crucial...
December 2017: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/29116093/the-challenge-of-mapping-the-human-connectome-based-on-diffusion-tractography
#13
Klaus H Maier-Hein, Peter F Neher, Jean-Christophe Houde, Marc-Alexandre Côté, Eleftherios Garyfallidis, Jidan Zhong, Maxime Chamberland, Fang-Cheng Yeh, Ying-Chia Lin, Qing Ji, Wilburn E Reddick, John O Glass, David Qixiang Chen, Yuanjing Feng, Chengfeng Gao, Ye Wu, Jieyan Ma, H Renjie, Qiang Li, Carl-Fredrik Westin, Samuel Deslauriers-Gauthier, J Omar Ocegueda González, Michael Paquette, Samuel St-Jean, Gabriel Girard, François Rheault, Jasmeen Sidhu, Chantal M W Tax, Fenghua Guo, Hamed Y Mesri, Szabolcs Dávid, Martijn Froeling, Anneriet M Heemskerk, Alexander Leemans, Arnaud Boré, Basile Pinsard, Christophe Bedetti, Matthieu Desrosiers, Simona Brambati, Julien Doyon, Alessia Sarica, Roberta Vasta, Antonio Cerasa, Aldo Quattrone, Jason Yeatman, Ali R Khan, Wes Hodges, Simon Alexander, David Romascano, Muhamed Barakovic, Anna Auría, Oscar Esteban, Alia Lemkaddem, Jean-Philippe Thiran, H Ertan Cetingul, Benjamin L Odry, Boris Mailhe, Mariappan S Nadar, Fabrizio Pizzagalli, Gautam Prasad, Julio E Villalon-Reina, Justin Galvis, Paul M Thompson, Francisco De Santiago Requejo, Pedro Luque Laguna, Luis Miguel Lacerda, Rachel Barrett, Flavio Dell'Acqua, Marco Catani, Laurent Petit, Emmanuel Caruyer, Alessandro Daducci, Tim B Dyrby, Tim Holland-Letz, Claus C Hilgetag, Bram Stieltjes, Maxime Descoteaux
Tractography based on non-invasive diffusion imaging is central to the study of human brain connectivity. To date, the approach has not been systematically validated in ground truth studies. Based on a simulated human brain data set with ground truth tracts, we organized an open international tractography challenge, which resulted in 96 distinct submissions from 20 research groups. Here, we report the encouraging finding that most state-of-the-art algorithms produce tractograms containing 90% of the ground truth bundles (to at least some extent)...
November 7, 2017: Nature Communications
https://www.readbyqxmd.com/read/29108984/transoral-outlet-reduction-a-comparison-of-pursestring-to-interrupted-stitch-technique
#14
Allison R Schulman, Nitin Kumar, Christopher C Thompson
BACKGROUND AND AIMS: Weight regain after Roux-en-Y gastric bypass (RYGB) correlates with dilated gastrojejunal anastomosis (GJA). Endoscopic sutured transoral outlet reduction (TORe) is safe and effective in the management, and has predominantly been performed by either (1) placing interrupted sutures at the GJA or (2) the creation of a pursestring. The aim of the current study was to compare these techniques. METHODS: All patients undergoing TORe using for weight regain after RYGB were prospectively enrolled...
November 3, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29092867/subsyndromal-delirium-and-institutionalization-among-patients-with-critical-illness
#15
Nathan E Brummel, Leanne M Boehm, Timothy D Girard, Pratik P Pandharipande, James C Jackson, Christopher G Hughes, Mayur B Patel, Jin H Han, Eduard E Vasilevskis, Jennifer L Thompson, Rameela Chandrasekhar, Gordon R Bernard, Robert S Dittus, E Wesley Ely
BACKGROUND: The prognostic importance of subsyndromal delirium is unknown. OBJECTIVE: To test whether duration of subsyndromal delirium is independently associated with institutionalization. METHODS: The Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) was used twice daily to assess for subsyndromal delirium in patients with respiratory failure or shock. Delirium was considered present if the assessment was positive. Subsyndromal delirium was considered present if the assessment was negative but the patient exhibited any CAM-ICU features...
November 2017: American Journal of Critical Care: An Official Publication, American Association of Critical-Care Nurses
https://www.readbyqxmd.com/read/29083042/practitioner-review-current-best-practice-in-the-use-of-parent-training-and-other-behavioural-interventions-in-the-treatment-of-children-and-adolescents-with-attention-deficit-hyperactivity-disorder
#16
REVIEW
David Daley, Saskia Van Der Oord, Maite Ferrin, Samuele Cortese, Marina Danckaerts, Manfred Doepfner, Barbara J Van den Hoofdakker, David Coghill, Margaret Thompson, Philip Asherson, Tobias Banaschewski, Daniel Brandeis, Jan Buitelaar, Ralf W Dittmann, Chris Hollis, Martin Holtmann, Eric Konofal, Michel Lecendreux, Aribert Rothenberger, Paramala Santosh, Emily Simonoff, Cesar Soutullo, Hans Christoph Steinhausen, Argyris Stringaris, Eric Taylor, Ian C K Wong, Alessandro Zuddas, Edmund J Sonuga-Barke
BACKGROUND: Behavioural interventions are recommended for use with children and young people with attention deficit hyperactivity disorder (ADHD); however, specific guidance for their implementation based on the best available evidence is currently lacking. METHODS: This review used an explicit question and answer format to address issues of clinical concern, based on expert interpretation of the evidence with precedence given to meta-analyses of randomised controlled trials...
October 30, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/29075966/endoscopic-sutured-gastroplasty-procedure-evolution-from-first-in-man-cases-through-current-technique
#17
Nitin Kumar, Barham K Abu Dayyeh, Gontrand Lopez-Nava Breviere, Manoel P Galvao Neto, Nicole P Sahdala, Sohail N Shaikh, Robert H Hawes, Christopher J Gostout, Mahesh K Goenka, Jorge R Orillac, Alonso Alvarado, Pichamol Jirapinyo, Natan Zundel, Christopher C Thompson
BACKGROUND: Endoscopic sutured gastroplasty (ESG) has evolved over time. With the advent of full-thickness endoscopic suturing, an efficient technique for ESG was developed and refined. METHODS: This prospective first-in-man trial started in April 2012 and represents the first use of full-thickness endoscopic suturing for primary obesity therapy. The trial focused on procedure development, reproducibility, safety, and short-term efficacy. The trial was performed at centers in five countries, in three phases...
October 26, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29069701/endoscopic-full-thickness-resection-of-fistula-tract-with-suture-closure
#18
Austin L Chiang, Andrew C Storm, Hiroyuki Aihara, Christopher C Thompson
No abstract text is available yet for this article.
October 25, 2017: Endoscopy
https://www.readbyqxmd.com/read/29064106/integration-of-mechanistic-and-pharmacokinetic-information-to-derive-oral-reference-dose-and-margin-of-exposure-values-for-hexavalent-chromium
#19
Chad M Thompson, Christopher R Kirman, Sean M Hays, Mina Suh, Seneca E Harvey, Deborah M Proctor, Julia E Rager, Laurie C Haws, Mark A Harris
The current US Environmental Protection Agency (EPA) reference dose (RfD) for oral exposure to chromium, 0.003 mg kg(-1)  day(-1) , is based on a no-observable-adverse-effect-level from a 1958 bioassay of rats exposed to ≤25 ppm hexavalent chromium [Cr(VI)] in drinking water. EPA characterizes the confidence in this RfD as "low." A more recent cancer bioassay indicates that Cr(VI) in drinking water is carcinogenic to mice at ≥30 ppm. To assess whether the existing RfD is health protective, neoplastic and non-neoplastic lesions from the 2 year cancer bioassay were modeled in a three-step process...
October 24, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29031960/the-effect-of-post-synthesis-aging-on-the-ligand-exchange-activity-of-iron-oxide-nanoparticles
#20
Kathleen Davis, Michael Vidmar, Airat Khasanov, Brian Cole, Melanie Ghelardini, Justin Mayer, Christopher Kitchens, Amar Nath, Brian A Powell, O Thompson Mefford
HYPOTHESIS: Ligand exchange is a widely-used method of controlling the surface chemistry of nanomaterials. Exchange is dependent on many factors including the age of the core particle being modified. Aging of the particles can impact surface structure and composition, which in turn can affect ligand binding. EXPERIMENTS: To quantify the effects of aging on ligand exchange, we employed a technique to track the exchange of radiolabeled (14)C-oleic acid with unlabeled, oleic acid bound to iron oxide nanoparticles...
September 23, 2017: Journal of Colloid and Interface Science
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