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JOURNAL ARTICLE
Viktoria Eleftheriadou, Carine Delattre, Shala Chetty-Mhlanga, Christopher Lee, Laura Girardat-Rotar, Iftekhar Khan, Amit Mathew, Andrew R Thompson
This retrospective study, using UK Clinical Practice Research Datalink and Hospital Episode Statistics databases, analysed 17,239 incident patients with vitiligo. Mean incidence of vitiligo was 0.16 (2010-2021) per 1000 person-years (range: 0.10 [2010-COVID] to 0.19 [2013/2018]); prevalence increased from 0.21% (2010) to 0.38% (2021). The most common comorbidities recorded after vitiligo diagnosis were diabetes (19.4%), eczema (8.9%), thyroid disease (7.5%), and rheumatoid arthritis (6.9%). Mental health diagnoses recorded at any time were most commonly depression and/or anxiety (24...
March 27, 2024: British Journal of Dermatology
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JOURNAL ARTICLE
Troy C Krzysiak, You-Jin Choi, Yong Joon Kim, Yunhan Yang, Christopher DeHaven, Lariah Thompson, Ryan Ponticelli, Mara M Mermigos, Laurel Thomas, Andrea Marquez, Ian Sipula, Jongsook Kim Kemper, Michael Jurczak, Gary Thomas, Angela M Gronenborn
Regulation of SIRT1 activity is vital to energy homeostasis and plays important roles in many diseases. We previously showed that insulin triggers the epigenetic regulator DBC1 to prime SIRT1 for repression by the multifunctional trafficking protein PACS-2. Here, we show that liver DBC1/PACS-2 regulates the diurnal inhibition of SIRT1, which is critically important for insulin-dependent switch in fuel metabolism from fat to glucose oxidation. We present the x-ray structure of the DBC1 S1-like domain that binds SIRT1 and an NMR characterization of how the SIRT1 N-terminal region engages DBC1...
April 2024: Protein Science
#23
JOURNAL ARTICLE
Braidy S Solie, Luke V Tollefson, Christopher P Doney, Jeremy M J O'Keefe, Will C Thompson, Robert F LaPrade
Returning to sport after anterior cruciate ligament reconstruction (ACLR) can be a challenging and complex process for the athlete, with the rate of return to the pre-injury level of sport observed to be less than athlete expectations. Of the athletes that do return to sport (RTS), knee re-injury rates remain high, and multiple studies have observed impaired athletic performance upon RTS after ACLR as well as reduced playing time, productivity, and career lengths. To mitigate re-injury and improve RTS outcomes, multiple RTS after ACLR consensus statements/clinical practice guidelines have recommended objective RTS testing criteria to be met prior to medical clearance for unrestricted sports participation...
March 25, 2024: International Journal of Sports Medicine
#24
JOURNAL ARTICLE
Karl J Fisher, Laura Shirtcliff, Greg Buchanan, Andrew W Thompson, Frank X Woolard, Donald H LaMunyon, Jonathan L Marshall, Maya B Baranouskas, Rodger B Voelker, Jason S Lusk, Charles E Wells, Raodoh Mohamath, Robert Kinsey, William R Lykins, Gabi Ramer-Denisoff, Christopher B Fox, Christopher J Paddon, Derek McPhee
Emulsions of the triterpene squalene ((6 E ,10 E ,14 E ,18 E )-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene, CAS 111-02-4) have been used as adjuvants in influenza vaccines since the 1990s. Traditionally sourced from shark liver oil, the overfishing of sharks and concomitant reduction in the oceanic shark population raises sustainability issues for vaccine adjuvant grade squalene. We report a semisynthetic route to squalene meeting current pharmacopeial specifications for use in vaccines that leverages the ready availability of trans -β-farnesene ((6 E )-7,11-dimethyl-3-methylene-1,6,10-dodecatriene, CAS 18794-84-8), manufactured from sustainable sugarcane via a yeast fermentation process...
December 15, 2023: Organic Process Research & Development
#25
JOURNAL ARTICLE
Amanda J Thompson, Christopher C Henrich, Danielle L Steelesmith, Jennifer Hughes, Donna Ruch, Jeffrey A Bridge, John V Campo, Cynthia A Fontanella
PURPOSE: To identify risk subgroups of youth suicide decedents using demographic and clinical psychiatric and medical diagnostic profiles to inform tailored youth suicide prevention efforts. METHODS: This study linked Ohio Medicaid and death certificate data for Medicaid enrolled youth aged 8-25 years who died by suicide between January 1, 2010, and December 31, 2020 (N = 511). Latent class analysis was used to identify distinct clinical risk subgroups. RESULTS: Three latent classes were identified...
March 21, 2024: Journal of Adolescent Health
#26
JOURNAL ARTICLE
Andrea Lorenzo Polo, Michael Nix, Christopher Thompson, Christopher John O'Hara, Jonathan Entwisle, Louis Murray, Ane L Appelt, Ola Weistrand, Stina Svensson
Deformable image registration (DIR) is a widely used technique in radiotherapy. Complex deformations, resulting from large anatomical changes, are a regular challenge. DIR algorithms generally seek a balance between capturing large deformations and preserving a smooth deformation vector field (DVF). We propose a novel structure-based term that can enhance the registration efficacy while ensuring a smooth DVF.
The proposed novel similarity metric for controlling structures was introduced as a new term into a commercially available algorithm...
March 22, 2024: Physics in Medicine and Biology
#27
JOURNAL ARTICLE
Kyana Y Garza, Mary E King, Chandandeep Nagi, Rachel J DeHoog, Jialing Zhang, Marta Sans, Anna Krieger, Clara L Feider, Alena V Bensussan, Michael F Keating, John Q Lin, Min Woo Sun, Robert Tibshirani, Christopher Pirko, Kirtan A Brahmbhatt, Ahmed R Al-Fartosi, Alastair M Thompson, Elizabeth Bonefas, James Suliburk, Stacey A Carter, Livia S Eberlin
IMPORTANCE: Surgery with complete tumor resection remains the main treatment option for patients with breast cancer. Yet, current technologies are limited in providing accurate assessment of breast tissue in vivo, warranting development of new technologies for surgical guidance. OBJECTIVE: To evaluate the performance of the MasSpec Pen for accurate intraoperative assessment of breast tissues and surgical margins based on metabolic and lipid information. DESIGN, SETTING, AND PARTICIPANTS: In this diagnostic study conducted between February 23, 2017, and August 19, 2021, the mass spectrometry-based device was used to analyze healthy breast and invasive ductal carcinoma (IDC) banked tissue samples from adult patients undergoing breast surgery for ductal carcinomas or nonmalignant conditions...
March 4, 2024: JAMA Network Open
#28
JOURNAL ARTICLE
Michael J Yabsley, Kayla B Garrett, Alec T Thompson, Erin K Box, Madeline R Giner, Ellen Haynes, Heather Barron, Renata M Schneider, Sarah M Coker, James C Beasley, Ernest J Borchert, Renn Tumlison, Allison Surf, Casey G Dukes, Colleen Olfenbuttel, Justin D Brown, Liandrie Swanepoel, Christopher A Cleveland
The genus Dracunculus contains numerous species of subcutaneous parasites of mammals and reptiles. In North America, there are at least three mammal-infecting species of Dracunculus . Reports of Dracunculus infections have been reported from river otters ( Lontra canadensis ) since the early 1900s; however, little is known about the species infecting otters or their ecology. Most reports of Dracunculus do not have a definitive species identified because females, the most common sex found due to their larger size and location in the extremities of the host, lack distinguishing morphological characteristics, and few studies have used molecular methods to confirm identifications...
April 2024: International Journal for Parasitology. Parasites and Wildlife
#29
JOURNAL ARTICLE
Pichamol Jirapinyo, Aunchalee Jaroenlapnopparat, Stephen D Zucker, Christopher C Thompson
PURPOSE: The mainstay of treatment for metabolic dysfunction-associated steatotic liver disease (MASLD) is weight loss. Endoscopic gastric remodeling (EGR) and glucagon-like peptide-1 receptor agonist (GLP-1RA) are effective weight loss therapies. This study aims to assess the effect of combining EGR with GLP-1RA on liver-related outcomes and weight profile. MATERIALS AND METHODS: This is a retrospective study of a prospectively collected registry of patients with MASLD and compensated advanced chronic liver disease (cACLD) who underwent EGR...
March 21, 2024: Obesity Surgery
#30
EDITORIAL
Jongsang Son, M Hongchul Sohn, Christopher K Thompson
No abstract text is available yet for this article.
2024: Front Rehabil Sci
#31
JOURNAL ARTICLE
John Kappelman, Lawrence C Todd, Christopher A Davis, Thure E Cerling, Mulugeta Feseha, Abebe Getahun, Racheal Johnsen, Marvin Kay, Gary A Kocurek, Brett A Nachman, Agazi Negash, Tewabe Negash, Kaedan O'Brien, Michael Pante, Minghua Ren, Eugene I Smith, Neil J Tabor, Dereje Tewabe, Hong Wang, Deming Yang, Solomon Yirga, Jordan W Crowell, Matthew F Fanuka, Teshager Habtie, Jayde N Hirniak, Carla Klehm, Natalia D Loewen, Sahleselasie Melaku, Sierra M Melton, Timothy S Myers, Sarah Millonig, Megan C Plummer, Keenan J Riordan, Nicholas A Rosenau, Anne Skinner, Abraham K Thompson, Lindsey M Trombetta, Adrienne Witzel, Ephrem Assefa, Maria Bodansky, Ayenachew A Desta, Christopher J Campisano, Daniel Dalmas, Connor Elliott, Metasebia Endalamaw, Nicholas J Ford, Frederick Foster, Tomas Getachew, Yibai Li Haney, Brittney H Ingram, Jonayah Jackson, Curtis W Marean, Sissi Mattox, Karla de la Cruz Medina, Gebretsadkan Mulubrhan, Keri Porter, Alexis Roberts, Perla Santillan, Alaric Sollenberger, Julia Sponholtz, Jessica Valdes, Lani Wyman, Meklit Yadeta, Sierra Yanny
Although modern humans left Africa multiple times over 100,000 years ago, those broadly ancestral to non-Africans dispersed less than 100,000 years ago1 . Most models hold that these events occurred through green corridors created during humid periods because arid intervals constrained population movements2 . Here we report an archaeological site-Shinfa-Metema 1, in the lowlands of northwest Ethiopia, with Youngest Toba Tuff cryptotephra dated to around 74,000 years ago-that provides early and rare evidence of intensive riverine-based foraging aided by the likely adoption of the bow and arrow...
March 20, 2024: Nature
#32
JOURNAL ARTICLE
Alexander S D Gamble, Kyle M A Thompson, Jessica L Bigg, Christopher Pignanelli, Lawrence L Spriet, Jamie F Burr
PURPOSE: To characterize and compare female ice hockey players' peak skating speed and acceleration ability during linear sprints and gameplay. We also sought to quantify the time spent at various speeds and the frequency of accelerations at different thresholds during games. METHODS: Seventeen varsity-level female ice hockey players (20 [1.4] y, 68.9 [4.9] kg, 167.6 [4.7] cm) participated in an on-ice practice session (performing 3 × 40-m linear sprints) and 4 regular-season games while being monitored using a local positioning system...
March 19, 2024: International Journal of Sports Physiology and Performance
#33
Judy Chen, Alexander Ngo, Raúl Rodríguez-Cruces, Jessica Royer, Maria Eugenia Caligiuri, Antonio Gambardella, Luis Concha, Simon S Keller, Fernando Cendes, Clarissa L Yasuda, Marina K M Alvim, Leonardo Bonilha, Ezequiel Gleichgerrcht, Niels K Focke, Barbara Kreilkamp, Martin Domin, Felix von Podewils, Soenke Langner, Christian Rummel, Roland Wiest, Pascal Martin, Raviteja Kotikalapudi, Benjamin Bender, Terence J O'Brien, Benjamin Sinclair, Lucy Vivash, Patrick Kwan, Patricia M Desmond, Elaine Lui, Gian Marco Duma, Paolo Bonanni, Alice Ballerini, Anna Elisabetta Vaudano, Stefano Meletti, Manuela Tondelli, Saud Alhusaini, Colin P Doherty, Gianpiero L Cavalleri, Norman Delanty, Reetta Kälviäinen, Graeme D Jackson, Magdalena Kowalczyk, Mario Mascalchi, Mira Semmelroch, Rhys H Thomas, Hamid Soltanian-Zadeh, Esmaeil Davoodi-Bojd, Junsong Zhang, Matteo Lenge, Renzo Guerrini, Emanuele Bartolini, Khalid Hamandi, Sonya Foley, Theodor Rüber, Tobias Bauer, Bernd Weber, Benoit Caldairou, Chantal Depondt, Julie Absil, Sarah J A Carr, Eugenio Abela, Mark P Richardson, Orrin Devinsky, Heath Pardoe, Mariasavina Severino, Pasquale Striano, Domenico Tortora, Erik Kaestner, Sean N Hatton, Donatello Arienzo, Sjoerd B Vos, Mina Ryten, Peter N Taylor, John S Duncan, Christopher D Whelan, Marian Galovic, Gavin P Winston, Sophia I Thomopoulos, Paul M Thompson, Sanjay M Sisodiya, Angelo Labate, Carrie R McDonald, Lorenzo Caciagli, Neda Bernasconi, Andrea Bernasconi, Sara Larivière, Dewi Schrader, Boris C Bernhardt
OBJECTIVES: Temporal lobe epilepsy (TLE) is commonly associated with mesiotemporal pathology and widespread alterations of grey and white matter structures. Evidence supports a progressive condition although the temporal evolution of TLE is poorly defined. This ENIGMA-Epilepsy study utilized multimodal magnetic resonance imaging (MRI) data to investigate structural alterations in TLE patients across the adult lifespan. We charted both grey and white matter changes and explored the covariance of age-related alterations in both compartments...
March 6, 2024: bioRxiv
#34
JOURNAL ARTICLE
Ying Liu, Jacquelyn Bainbridge, Stefan Sillau, Sarah Rajkovic, Michelle Adkins, Christopher H Domen, John A Thompson, Tristan Seawalt, Jost Klawitter, Cristina Sempio, Grace Chin, Lisa Forman, Michelle Fullard, Trevor Hawkins, Lauren Seeberger, Heike Newman, David Vu, Maureen Anne Leehey
BACKGROUND: Cannabis use is frequent in Parkinson's disease (PD), despite inadequate evidence of benefits and risks. OBJECTIVE: The aim is to study short-term efficacy and tolerability of relatively high cannabidiol (CBD)/low Δ-9-tetrahydrocannabinol (THC) to provide preliminary data for a longer trial. METHODS: Persons with PD with ≥20 on motor Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) who had negative cannabis testing took cannabis extract (National Institute of Drug Abuse) oral sesame oil solution for 2 weeks, increasing to final dose of 2...
March 15, 2024: Movement Disorders: Official Journal of the Movement Disorder Society
#35
JOURNAL ARTICLE
Seok Kyu Kang, Nicole A Hawkins, Christopher H Thompson, Erin M Baker, Dennis M Echevarria-Cooper, Levi Barse, Tyler Thenstedt, Conor J Dixon, Nathan Speakes, Alfred L George, Jennifer A Kearney
Pathogenic variants in KCNB1 are associated with a neurodevelopmental disorder spectrum that includes global developmental delays, cognitive impairment, abnormal electroencephalogram (EEG) patterns, and epilepsy with variable age of onset and severity. Additionally, there are prominent behavioral disturbances, including hyperactivity, aggression, and features of autism spectrum disorder. The most frequently identified recurrent variant is KCNB1-p.R306C, a missense variant located within the S4 voltage-sensing transmembrane domain...
March 12, 2024: Neurobiology of Disease
#36
JOURNAL ARTICLE
Annie A Wu, Elizabeth D Thompson, John L Cameron, Jin He, Richard A Burkhart, William R Burns, Kelly J Lafaro, Christopher R Shubert, Marcia I Canto, Elliot K Fishman, Ralph H Hruban
The radiologic finding of focal stenosis of the main pancreatic duct is highly suggestive of pancreatic cancer. Even in the absence of a mass lesion, focal duct stenosis can lead to surgical resection of the affected portion of the pancreas. We present four patients with distinctive pathology associated with non-neoplastic focal stenosis of the main pancreatic duct. The pathology included stenosis of the pancreatic duct accompanied by wavy, acellular, serpentine-like fibrosis, chronic inflammation with foreign body-type giant cell reaction, and calcifications...
March 14, 2024: American Journal of Surgical Pathology
#37
JOURNAL ARTICLE
Rachel L Randell, Stephen J Balevic, Rachel G Greenberg, Michael Cohen-Wolkowiez, Elizabeth J Thompson, Saranya Venkatachalam, Michael J Smith, Catherine Bendel, Joseph M Bliss, Hala Chaaban, Rakesh Chhabra, Christiane E L Dammann, L Corbin Downey, Chi Hornik, Naveed Hussain, Matthew M Laughon, Adrian Lavery, Fernando Moya, Matthew Saxonhouse, Gregory M Sokol, Andrea Trembath, Joern-Hendrik Weitkamp, Christoph P Hornik
Pharmacokinetic models rarely undergo external validation in vulnerable populations such as critically ill infants, thereby limiting the accuracy, efficacy, and safety of model-informed dosing in real-world settings. Here, we describe an opportunistic approach using dried blood spots (DBS) to evaluate a population pharmacokinetic model of metronidazole in critically ill preterm infants of gestational age (GA) ≤31 weeks from the Metronidazole Pharmacokinetics in Premature Infants (PTN_METRO, NCT01222585) study...
March 13, 2024: Antimicrobial Agents and Chemotherapy
#38
JOURNAL ARTICLE
Carmen L Diaz Soria, Teresa Attenborough, Zhigang Lu, Santiago Fontenla, Jennie Graham, Christopher Hall, Sam Thompson, Toby G R Andrews, Kate A Rawlinson, Matthew Berriman, Gabriel Rinaldi
Schistosomiasis is a major Neglected Tropical Disease, caused by the infection with blood flukes in the genus Schistosoma. To complete the life cycle, the parasite undergoes asexual and sexual reproduction within an intermediate snail host and a definitive mammalian host, respectively. The intra-molluscan phase provides a critical amplification step that ensures a successful transmission. However, the cellular and molecular mechanisms underlying the development of the intra-molluscan stages remain poorly understood...
March 12, 2024: Scientific Reports
#39
JOURNAL ARTICLE
Emily E Doub, Stacey L Vigil, Alec T Thompson, Avery L Korns, Michael J Yabsley, Mark G Ruder, Christopher A Cleveland
Biting midges in the genus Culicoides Latreille (Diptera: Ceratopogonidae) are known to transmit many pathogens of veterinary and medical concern. Although much work has been done globally and in certain regions of North America, Culicoides spp. research in rural Appalachia is limited. To begin characterizing the distribution and community structure of Culicoides spp. in Appalachia, we surveyed 2 distinct sites in the Ridge and Valley ecoregion of northeastern Tennessee, USA, from April 2021-September 2021...
March 12, 2024: Journal of Medical Entomology
#40
Samyra R Cox, Abhay Kadam, Sachin Atre, Akshay N Gupte, Hojoon Sohn, Nikhil Gupte, Trupti Sawant, Vishal Mhadeshwar, Ryan Thompson, Emily Kendall, Christopher Hofmann, Nishi Suryavanshi, Deanna Kerrigan, Srikanth Tripathy, Arjunlal Kakrani, Madhusudan S Barthwal, Vidya Mave, Jonathan E Golub
No abstract text is available yet for this article.
March 11, 2024: Trials
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