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Christopher Thompson

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https://www.readbyqxmd.com/read/28435122/global-motion-perception-is-related-to-motor-function-in-4-5-year-old-children-born-at-risk-of-abnormal-development
#1
Arijit Chakraborty, Nicola S Anstice, Robert J Jacobs, Nabin Paudel, Linda L LaGasse, Barry M Lester, Christopher J D McKinlay, Jane E Harding, Trecia A Wouldes, Benjamin Thompson
Global motion perception is often used as an index of dorsal visual stream function in neurodevelopmental studies. However, the relationship between global motion perception and visuomotor control, a primary function of the dorsal stream, is unclear. We measured global motion perception (motion coherence threshold; MCT) and performance on standardized measures of motor function in 606 4.5-year-old children born at risk of abnormal neurodevelopment. Visual acuity, stereoacuity and verbal IQ were also assessed...
April 20, 2017: Vision Research
https://www.readbyqxmd.com/read/28431138/cardiovascular-outcome-trials-in-patients-with-chronic-kidney-disease-challenges-associated-with-selection-of-patients-and-endpoints
#2
Patrick Rossignol, Rajiv Agarwal, Bernard Canaud, Alan Charney, Gilles Chatellier, Jonathan C Craig, William C Cushman, Ronald T Gansevoort, Bengt Fellström, Dahlia Garza, Nicolas Guzman, Frank A Holtkamp, Gerard M London, Ziad A Massy, Alexandre Mebazaa, Peter G M Mol, Marc A Pfeffer, Yves Rosenberg, Luis M Ruilope, Jonathan Seltzer, Amil M Shah, Salim Shah, Bhupinder Singh, Bergur V Stefánsson, Norman Stockbridge, Wendy Gattis Stough, Kristian Thygesen, Michael Walsh, Christoph Wanner, David G Warnock, Christopher S Wilcox, Janet Wittes, Bertram Pitt, Aliza Thompson, Faiez Zannad
Although cardiovascular disease is a major health burden for patients with chronic kidney disease, most cardiovascular outcome trials have excluded patients with advanced chronic kidney disease. Moreover, the major cardiovascular outcome trials that have been conducted in patients with end-stage renal disease have not demonstrated a treatment benefit. Thus, clinicians have limited evidence to guide the management of cardiovascular disease in patients with chronic kidney disease, particularly those on dialysis...
April 18, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28426003/a-temperate-rocky-super-earth-transiting-a-nearby-cool-star
#3
Jason A Dittmann, Jonathan M Irwin, David Charbonneau, Xavier Bonfils, Nicola Astudillo-Defru, Raphaëlle D Haywood, Zachory K Berta-Thompson, Elisabeth R Newton, Joseph E Rodriguez, Jennifer G Winters, Thiam-Guan Tan, Jose-Manuel Almenara, François Bouchy, Xavier Delfosse, Thierry Forveille, Christophe Lovis, Felipe Murgas, Francesco Pepe, Nuno C Santos, Stephane Udry, Anaël Wünsche, Gilbert A Esquerdo, David W Latham, Courtney D Dressing
M dwarf stars, which have masses less than 60 per cent that of the Sun, make up 75 per cent of the population of the stars in the Galaxy. The atmospheres of orbiting Earth-sized planets are observationally accessible via transmission spectroscopy when the planets pass in front of these stars. Statistical results suggest that the nearest transiting Earth-sized planet in the liquid-water, habitable zone of an M dwarf star is probably around 10.5 parsecs away. A temperate planet has been discovered orbiting Proxima Centauri, the closest M dwarf, but it probably does not transit and its true mass is unknown...
April 19, 2017: Nature
https://www.readbyqxmd.com/read/28425093/low-dose-aspirin-use-and-cognitive-function-in-older-age-a-systematic-review-and-meta-analysis
#4
Nicola Veronese, Brendon Stubbs, Stefania Maggi, Trevor Thompson, Patricia Schofield, Christoph Muller, Ping-Tao Tseng, Pao-Yen Lin, André F Carvalho, Marco Solmi
OBJECTIVES: To investigate whether low-dose aspirin (<300 mg/d) can influence the onset of cognitive impairment or dementia in observational studies and improve cognitive test scores in randomized controlled trials (RCTs) in participants without dementia. DESIGN: Systematic review and meta-analysis. SETTING: Observational and interventional studies. PARTICIPANTS: Individuals with no dementia or cognitive impairment initially...
April 20, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28416535/pneumatic-dental-extractions-an-unusual-cause-of-extensive-cervical-surgical-emphysema
#5
Christopher Thompson, Rohit Gohil
A 50-year-old fit and well man presented to the Accident and Emergency Department in a tertiary centre following lower molar extraction, complaining of voice hoarseness with neck and facial swelling. Clinical examination along with plain film radiography revealed pneumomediastinum and extensive cervical surgical emphysema. He was subsequently admitted for observation and managed conservatively under the ENT team with input from the maxillofacial and anaesthetic teams. With supportive treatment only, the emphysema resolved and he remained well up until discharge...
April 17, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28416512/investigating-the-genetic-architecture-of-the-pr-interval-using-clinical-phenotypes
#6
Jonathan D Mosley, M Benjamin Shoemaker, Quinn S Wells, Dawood Darbar, Christian M Shaffer, Todd L Edwards, Lisa Bastarache, Catherine A McCarty, Will Thompson, Christopher G Chute, Gail P Jarvik, David R Crosslin, Eric B Larson, Iftikhar J Kullo, Jennifer A Pacheco, Peggy L Peissig, Murray H Brilliant, James G Linneman, John S Witte, Josh C Denny, Dan M Roden
BACKGROUND: One potential use for the PR interval is as a biomarker of disease risk. We hypothesized that quantifying the shared genetic architectures of the PR interval and a set of clinical phenotypes would identify genetic mechanisms contributing to PR variability and identify diseases associated with a genetic predictor of PR variability. METHODS AND RESULTS: We used ECG measurements from the ARIC study (Atherosclerosis Risk in Communities; n=6731 subjects) and 63 genetically modulated diseases from the eMERGE network (Electronic Medical Records and Genomics; n=12 978)...
April 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/28411294/hospital-medicine-and-perioperative-care-a-framework-for-high-quality-high-value-collaborative-care
#7
REVIEW
Rachel E Thompson, Kurt Pfeifer, Paul J Grant, Cornelia Taylor, Barbara Slawski, Christopher Whinney, Laurence Wellikson, Amir K Jaffer
BACKGROUND: Hospitalists have long been involved in optimizing perioperative care for medically complex patients. In 2015, the Society of Hospital Medicine organized the Perioperative Care Work Group to summarize this experience and to develop a framework for providing optimal perioperative care. METHODS: The work group, which consisted of perioperative care experts from institutions throughout the United States, reviewed current hospitalist-based perioperative care programs, compiled key issues in each perioperative phase, and developed a framework to highlight essential elements to be considered...
April 2017: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/28408435/neurturin-and-a-glp-1-analogue-act-synergistically-to-alleviate-diabetes-in-zucker-diabetic-fatty-rats
#8
James L Trevaskis, Chester Bittencourt Sacramento, Hani Jouihan, Safina Ali, John Le Lay, Stephanie Oldham, Nicholas Bhagroo, Brandon B Boland, Jennifer Cann, Yuan Chang, Terrence O'Day, Victor Howard, Christina Reers, Maria Sorhede Winzell, David M Smith, Michael Feigh, Pernille Barkholt, Kay Schreiter, Matthias Austen, Uwe Andag, Simon Thompson, Lutz Jermutus, Matthew P Coghlan, Joseph Grimsby, Cord Dohrmann, Christopher J Rhodes, Cristina M Rondinone, Arun Sharma
Neurturin (NRTN), a member of the glial-derived neurotrophic factor (GDNF) family, was identified from an embryonic chicken pancreatic cDNA library in a screen for secreted factors. Here, we assessed the potential antidiabetic activities of NRTN relative to liraglutide, a GLP-1 receptor agonist, in Zucker diabetic fatty (ZDF) rats. Subcutaneous administration of NRTN to 8-week-old male ZDF rats prevented the development of hyperglycemia and improved metabolic parameters similar to liraglutide. NRTN treatment increased pancreatic insulin content and β-cell mass, and prevented deterioration of islet organization...
April 13, 2017: Diabetes
https://www.readbyqxmd.com/read/28407579/plga-peg-nano-delivery-system-for-epigenetic-therapy
#9
Asia Naz, Yi Cui, Christopher J Collins, David H Thompson, Joseph Irudayaraj
Efficient delivery of cytidine analogues such as Azacitidine (AZA) into solid tumors constitutes a primary challenge in epigenetic therapies. We developed a di-block nano-vector based on poly(lactic-co-glycolic acid) (PLGA) and poly(ethylene glycol) (PEG) for stabilization of the conjugated AZA under physiological conditions. With equimolar drug content, our nano-conjugate could elicit a better anti-proliferative effect over free drug in breast cancer both in vitro and in vivo, through reactivation of p21 and BRCA1 to restrict cell proliferation...
April 10, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28401679/the-role-of-cholesterol-metabolism-and-various-steroid-abnormalities-in-autism-spectrum-disorders-a-hypothesis-paper
#10
REVIEW
Christopher Gillberg, Elisabeth Fernell, Eva Kočovská, Helen Minnis, Thomas Bourgeron, Lucy Thompson, Clare S Allely
Based on evidence from the relevant research literature, we present a hypothesis that there may be a link between cholesterol, vitamin D, and steroid hormones which subsequently impacts on the development of at least some of the "autisms" [Coleman & Gillberg]. Our hypothesis, driven by the peer reviewed literature, posits that there may be links between cholesterol metabolism, which we will refer to as "steroid metabolism" and findings of steroid abnormalities of various kinds (cortisol, testosterone, estrogens, progesterone, vitamin D) in autism spectrum disorder (ASD)...
April 12, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28400472/novel-selective-%C3%AE-1-adrenoceptor-antagonists-for-concomitant-cardiovascular-and-respiratory-disease
#11
Jillian G Baker, Sheila M Gardiner, Jeanette Woolard, Christophe Fromont, Gopal P Jadhav, Shailesh N Mistry, Kevin S J Thompson, Barrie Kellam, Stephen J Hill, Peter M Fischer
β-Blockers reduce mortality and improve symptoms in people with heart disease; however, current clinically available β-blockers have poor selectivity for the cardiac β1-adrenoceptor (AR) over the lung β2-AR. Unwanted β2-blockade risks causing life-threatening bronchospasm and reduced efficacy of β2-agonist emergency rescue therapy. Thus, current life-prolonging β-blockers are contraindicated in patients with both heart disease and asthma. Here, we describe NDD-713 and -825, novel highly β1-selective neutral antagonists with good pharmaceutical properties that can potentially overcome this limitation...
April 11, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28397980/uterine-remodelling-during-pregnancy-and-pseudopregnancy-in-the-brushtail-possum-trichosurus-vulpecula-phalangeridae
#12
Melanie K Laird, Hanon McShea, Bronwyn M McAllan, Christopher R Murphy, Michael B Thompson
The formation of a placenta is critical for successful mammalian pregnancy and requires remodelling of the uterine epithelium. In eutherian mammals, remodelling involves specific morphological changes that often correlate with the mode of embryonic attachment. Given the differences between marsupial and eutherian placentae, formation of a marsupial placenta may involve patterns of uterine remodelling that are different from those in eutherians. Here we present a detailed morphological study of the uterus of the brushtail possum (Trichosurus vulpecula; Phalangeridae) throughout pregnancy, using both scanning and transmission electron microscopy, to identify whether uterine changes in marsupials correlate with mode of embryonic attachment as they do in eutherian mammals...
April 11, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28391700/effect-of-water-chemistry-and-hydrodynamics-on-nitrogen-transformation-activity-and-microbial-community-functional-potential-in-hyporheic-zone-sediment-columns
#13
Yuanyuan Liu, Chongxuan Liu, William C Nelson, Liang Shi, Fen Xu, Yunde Liu, Ailan Yan, Lirong Zhong, Christopher Thompson, James K Fredrickson, John M Zachara
Hyporheic zones (HZ) are active biogeochemical regions where groundwater and surface water mix. N transformations in HZ sediments were investigated in columns with a focus on understanding how the dynamic changes in groundwater and surface water mixing affect microbial community and its biogeochemical function with respect to N transformations. The results indicated that denitrification, DNRA, and nitrification rates and products changed quickly in response to changes in water and sediment chemistry, fluid residence time, and groundwater-surface water exchange...
April 18, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28389196/improving-guideline-compliance-in-australia-with-a-national-percutaneous-coronary-intervention-outcomes-registry
#14
David Eccleston, Mark Horrigan, Tony Rafter, Geoffrey Holt, Stephen G Worthley, Peter Sage, Alan Whelan, Christopher Reid, Peter L Thompson
BACKGROUND: Secondary prevention strategies after percutaneous coronary intervention (PCI) include statins and dual anti-platelet therapy, however there are significant gaps between guidelines and practice. Contemporary PCI practice requires comprehensive data collection to allow dynamic auditing and benchmarking of key performance and safety indices. Genesis HeartCare is Australia's largest collaborative venture of cardiologists, practising at over 40 public and private hospitals. We hypothesised that measurement and local reporting of data would improve patient outcomes through improving compliance with guideline therapies...
February 28, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28384479/mutant-huntingtin-disrupts-the-nuclear-pore-complex
#15
Jonathan C Grima, J Gavin Daigle, Nicolas Arbez, Kathleen C Cunningham, Ke Zhang, Joseph Ochaba, Charlene Geater, Eva Morozko, Jennifer Stocksdale, Jenna C Glatzer, Jacqueline T Pham, Ishrat Ahmed, Qi Peng, Harsh Wadhwa, Olga Pletnikova, Juan C Troncoso, Wenzhen Duan, Solomon H Snyder, Laura P W Ranum, Leslie M Thompson, Thomas E Lloyd, Christopher A Ross, Jeffrey D Rothstein
Huntington's disease (HD) is caused by an expanded CAG repeat in the Huntingtin (HTT) gene. The mechanism(s) by which mutant HTT (mHTT) causes disease is unclear. Nucleocytoplasmic transport, the trafficking of macromolecules between the nucleus and cytoplasm, is tightly regulated by nuclear pore complexes (NPCs) made up of nucleoporins (NUPs). Previous studies offered clues that mHTT may disrupt nucleocytoplasmic transport and a mutation of an NUP can cause HD-like pathology. Therefore, we evaluated the NPC and nucleocytoplasmic transport in multiple models of HD, including mouse and fly models, neurons transfected with mHTT, HD iPSC-derived neurons, and human HD brain regions...
April 5, 2017: Neuron
https://www.readbyqxmd.com/read/28379574/the-role-of-angiogenesis-in-group-3-medulloblastoma-pathogenesis-and-survival
#16
Eric M Thompson, Stephen T Keir, Talaignair Venkatraman, Christopher Lascola, Kristen W Yeom, Andrew B Nixon, Yingmiao Liu, Daniel Picard, Marc Remke, Darell D Bigner, Vijay Ramaswamy, Michael D Taylor
Background: Of the 4 medulloblastoma subgroups, Group 3 is the most aggressive but the importance of angiogenesis is unknown. This study sought to determine the role of angiogenesis and identify clinically relevant biomarkers of tumor vascularity and survival in Group 3 medulloblastoma. Methods: VEGFA mRNA expression and survival from several patient cohorts were analyzed. Group 3 xenografts were implanted intracranially in nude rats. Dynamic susceptibility weighted (DSC) MRI and susceptibility weighted imaging (SWI) were obtained...
April 3, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28374861/erratum-molecular-analysis-of-the-factorless-internal-ribosome-entry-site-in-cricket-paralysis-virus-infection
#17
Craig H Kerr, Zi Wang Ma, Christopher J Jang, Sunnie R Thompson, Eric Jan
No abstract text is available yet for this article.
April 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28369767/multiple-targets-for-flecainide-action-implications-for-cardiac-arrhythmogenesis
#18
REVIEW
Samantha C Salvage, Karthik H Chandrasekharan, Kamalan Jeevaratnam, Angela F Dulhunty, Andrew J Thompson, Antony P Jackson, Christopher L-H Huang
Flecainide suppresses cardiac tachyarrhythmias including paroxysmal atrial fibrillation, supraventricular tachycardia, arrhythmic long QT syndromes (LQTS), as well as the Ca(2+) -mediated, catecholaminergic polymorphic ventricular, tachycardia (CPVT). However, flecainide can also exert pro-arrhythmic effects most notably following myocardial infarction and when used to diagnose Brugada Syndrome (BrS). These divergent actions result from its physiological and pharmacological actions at multiple, interacting, levels of cellular organisation...
April 3, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28367633/the-hybrid-search-a-mass-spectral-library-search-method-for-discovery-of-modifications-in-proteomics
#19
Meghan C Burke, Yuri A Mirokhin, Dmitrii V Tchekhovskoi, Sanford P Markey, Jenny Heidbrink Thompson, Christopher Larkin, Stephen E Stein
We present a mass spectral library-based method to identify tandem mass spectra of peptides that contain unanticipated modifications and amino acid variants. We describe this as a "hybrid" method because it combines matching both ion m/z and mass losses. The mass loss is the difference between the mass of an ion peak and the mass of its precursor. This difference, termed DeltaMass, is used to shift the product ions in the library spectrum that contain the modification, thereby allowing library product ions that contain the unexpected modification to match the query spectrum...
April 11, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28366551/outcomes-following-thoracotomy-or-thoracoscopic-vascular-ring-division-in-children-and-young-adults
#20
Melissa A Herrin, David Zurakowski, Francis Fynn-Thompson, Christopher W Baird, Pedro J Del Nido, Sitaram M Emani
OBJECTIVE: To determine the short- and intermediate-term outcomes following vascular ring division by video-assisted thoracoscopic (VATS) or thoracotomy approach. METHODS: This study is a retrospective review of patients with double aortic arch or right aortic arch with aberrant left subclavian artery and left ligamentum (RAA with LSCA/LL) who underwent division via left thoracotomy or VATS approach at a single institution. Outcome measures included operation duration (OR time), hospital length of stay (LOS), postoperative complications, and freedom from reintervention...
March 11, 2017: Journal of Thoracic and Cardiovascular Surgery
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