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Chris Thompson

Jonathan C Niclis, Carlos W Gantner, Walaa F Alsanie, Stuart J McDougall, Chris R Bye, Andrew G Elefanty, Edouard G Stanley, John M Haynes, Colin W Pouton, Lachlan H Thompson, Clare L Parish
: : Recent studies have shown evidence for the functional integration of human pluripotent stem cell (hPSC)-derived ventral midbrain dopamine (vmDA) neurons in animal models of Parkinson's disease. Although these cells present a sustainable alternative to fetal mesencephalic grafts, a number of hurdles require attention prior to clinical translation. These include the persistent use of xenogeneic reagents and challenges associated with scalability and storage of differentiated cells. In this study, we describe the first fully defined feeder- and xenogeneic-free protocol for the generation of vmDA neurons from hPSCs and utilize two novel reporter knock-in lines (LMX1A-eGFP and PITX3-eGFP) for in-depth in vitro and in vivo tracking...
October 14, 2016: Stem Cells Translational Medicine
Yogesh Sharma, Michelle Miller, Rashmi Shahi, Paul Hakendorf, Chris Horwood, Campbell Thompson
BACKGROUND: The rate of malnutrition among hospitalised elderly patients in Australia is 42.3%. Malnutrition is known to lead to significant adverse outcomes for the patients and increase hospital costs through increased use of resources. AIM: This study assessed nutrition screening adequacy and investigated factors associated with missed opportunity to diagnose malnutrition. METHODS: A prospective cross-sectional study involving 205 general medical patients aged ≥60 years admitted acutely in a tertiary hospital over a period of 1 year...
October 13, 2016: British Journal of Nursing: BJN
Bonnie Alexander, Andrea L Murray, Wai Yen Loh, Lillian G Matthews, Chris Adamson, Richard Beare, Jian Chen, Claire E Kelly, Sandra Rees, Simon K Warfield, Peter J Anderson, Lex W Doyle, Alicia J Spittle, Jeanie L Y Cheong, Marc L Seal, Deanne K Thompson
Investigating neonatal brain structure and function can offer valuable insights into behaviour and cognition in healthy and clinical populations; both at term age, and longitudinally in comparison with later time points. Parcellated brain atlases for adult populations are readily available, however warping infant data to adult template space is not ideal due to morphological and tissue differences between these groups. Several parcellated neonatal atlases have been developed, although there remains strong demand for manually parcellated ground truth data with detailed cortical definition...
October 7, 2016: NeuroImage
Monica Vaccari, Shari N Gordon, Slim Fourati, Luca Schifanella, Namal P M Liyanage, Mark Cameron, Brandon F Keele, Xiaoying Shen, Georgia D Tomaras, Erik Billings, Mangala Rao, Amy W Chung, Karen G Dowell, Chris Bailey-Kellogg, Eric P Brown, Margaret E Ackerman, Diego A Vargas-Inchaustegui, Stephen Whitney, Melvin N Doster, Nicolo Binello, Poonam Pegu, David C Montefiori, Kathryn Foulds, David S Quinn, Mitzi Donaldson, Frank Liang, Karin Loré, Mario Roederer, Richard A Koup, Adrian McDermott, Zhong-Min Ma, Christopher J Miller, Tran B Phan, Donald N Forthal, Matthew Blackburn, Francesca Caccuri, Massimiliano Bissa, Guido Ferrari, Vaniambadi Kalyanaraman, Maria G Ferrari, DeVon Thompson, Marjorie Robert-Guroff, Silvia Ratto-Kim, Jerome H Kim, Nelson L Michael, Sanjay Phogat, Susan W Barnett, Jim Tartaglia, David Venzon, Donald M Stablein, Galit Alter, Rafick-Pierre Sekaly, Genoveffa Franchini
No abstract text is available yet for this article.
October 6, 2016: Nature Medicine
Laura A Verbruggen, Melissa M Thompson, Chris J Durall
No abstract text is available yet for this article.
September 26, 2016: Journal of Sport Rehabilitation
Jeanna Jacobi, Mónica García-Barros, Shyam Rao, Jimmy A Rotolo, Chris Thompson, Aviram Mizrachi, Regina Feldman, Katia Manova, Alicja Bielawska, Jacek Bielawska, Zvi Fuks, Richard Kolesnick, Adriana Haimovitz-Friedman
Despite great promise, combining anti-angiogenic and conventional anti-cancer drugs has produced limited therapeutic benefit in clinical trials, presumably because mechanisms of anti-angiogenic tissue response remain only partially understood. Here we define a new paradigm, in which anti-angiogenic drugs can be used to chemosensitize tumors by targeting the endothelial acid sphingomyelinase (ASMase) signal transduction pathway. We demonstrate that paclitaxel and etoposide, but not cisplatin, confer ASMase-mediated endothelial injury within minutes...
October 1, 2016: Cellular Signalling
Richard Pebody, Fiona Warburton, Joanna Ellis, Nick Andrews, Alison Potts, Simon Cottrell, Jillian Johnston, Arlene Reynolds, Rory Gunson, Catherine Thompson, Monica Galiano, Chris Robertson, Rachel Byford, Naomh Gallagher, Mary Sinnathamby, Ivelina Yonova, Sameera Pathirannehelage, Matthew Donati, Catherine Moore, Simon de Lusignan, Jim McMenamin, Maria Zambon
The United Kingdom (UK) is in the third season of introducing universal paediatric influenza vaccination with a quadrivalent live attenuated influenza vaccine (LAIV). The 2015/16 season in the UK was initially dominated by influenza A(H1N1)pdm09 and then influenza of B/Victoria lineage, not contained in that season's adult trivalent inactivated influenza vaccine (IIV). Overall adjusted end-of-season vaccine effectiveness (VE) was 52.4% (95% confidence interval (CI): 41.0-61.6) against influenza-confirmed primary care consultation, 54...
September 22, 2016: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
Vassiliki L Tsikitis, Aimee Potter, Motomi Mori, Julie A Buckmeier, Christina R Preece, Chris A Harrington, Angela N Bartley, Achyut Bhattacharyya, Stanley R Hamilton, Peter Lance, Patricia A Thompson
Colorectal cancer (CRC) and adenoma adjacent to cancer exhibit distinct microRNA (miR) alterations in an apparent mucosa-to-adenocarcinoma sequence. The pattern of microRNAs in screen-detected polyps in relation to histologic features and cancer risk has not been investigated. miR expression analysis was performed on normal mucosa (NM), hyperplastic polyps (HPs), tubular adenomas (TAs), tubulovillous adenomas or high-grade dysplasia (TVHGs), and serrated polyps (sessile serrated adenoma/polyps, SSA/Ps, and traditional serrated adenomas, TSAs) in biopsy specimens from 109 patients undergoing screening/surveillance colonoscopy...
September 22, 2016: Cancer Prevention Research
Serban Radian, Yoan Diekmann, Plamena Gabrovska, Brendan Holland, Lisa Bradley, Helen Wallace, Karen Stals, Anna-Marie Bussell, Karen McGurren, Martin Cuesta, Anthony W Ryan, Maria Herincs, Laura C Hernández-Ramírez, Aidan Holland, Jade Samuels, Elena Daniela Aflorei, Sayka Barry, Judit Dénes, Ida Pernicova, Craig E Stiles, Giampaolo Trivellin, Ronan McCloskey, Michal Ajzensztejn, Noina Abid, Scott A Akker, Moises Mercado, Mark Cohen, Rajesh V Thakker, Stephanie Baldeweg, Ariel Barkan, Madalina Musat, Miles Levy, Stephen M Orme, Martina Unterländer, Joachim Burger, Ajith V Kumar, Sian Ellard, Joseph McPartlin, Ross McManus, Gerard J Linden, Brew Atkinson, David J Balding, Amar Agha, Chris J Thompson, Steven J Hunter, Mark G Thomas, Patrick J Morrison, Márta Korbonits
The aryl hydrocarbon receptor interacting protein (AIP) founder mutation R304(*) (or p.R304(*) ; NM_003977.3:c.910C>T, p.Arg304Ter) identified in Northern Ireland (NI) predisposes to acromegaly/gigantism; its population health impact remains unexplored. We measured R304(*) carrier frequency in 936 Mid Ulster, 1,000 Greater Belfast (both in NI) and 2,094 Republic of Ireland (ROI) volunteers and in 116 NI or ROI acromegaly/gigantism patients. Carrier frequencies were 0.0064 in Mid Ulster (95%CI = 0.0027-0...
September 21, 2016: Human Mutation
Eric B Larson, Chris Tachibana, Ella Thompson, Gloria D Coronado, Lynn DeBar, Laura M Dember, Stacey Honda, Susan S Huang, Jeffrey G Jarvik, Christine Nelson, Edward Septimus, Greg Simon, Karin E Johnson
Pragmatic clinical trials are increasingly common because they have the potential to yield findings that are directly translatable to real-world healthcare settings. Pragmatic clinical trials need to integrate research into clinical workflow without placing an undue burden on the delivery system. This requires a research partnership between investigators and healthcare system representatives. This paper, organized as a series of case studies drawn from our experience in the NIH Health Care Systems Research Collaboratory, presents guidance from informational interviews of physician-scientists, health services researchers, and delivery system leaders who recently launched pragmatic clinical trials...
September 2016: Healthcare
Amanda Hall, Bethan Copsey, Helen Richmond, Jacqueline Thompson, Manuela Ferreira, Jane Latimer, Chris G Maher
BACKGROUND: Tai chi is recommended for musculoskeletal conditions, however, the evidence for its clinical effectiveness is uncertain. PURPOSE: To determine whether tai chi is beneficial for clinical outcomes in people with musculoskeletal pain. DATA SOURCES: Seven databases EMBASE, PEDro, AMED, MEDLINE, CINAHL, Sport Discus, and the Cochrane Central Register of Controlled Trials. STUDY SELECTION: Randomized controlled trials of tai chi for people with a chronic musculoskeletal condition were included...
September 15, 2016: Physical Therapy
Jenny L Donovan, Freddie C Hamdy, J Athene Lane, Malcolm Mason, Chris Metcalfe, Eleanor Walsh, Jane M Blazeby, Tim J Peters, Peter Holding, Susan Bonnington, Teresa Lennon, Lynne Bradshaw, Deborah Cooper, Phillipa Herbert, Joanne Howson, Amanda Jones, Norma Lyons, Elizabeth Salter, Pauline Thompson, Sarah Tidball, Jan Blaikie, Catherine Gray, Prasad Bollina, James Catto, Andrew Doble, Alan Doherty, David Gillatt, Roger Kockelbergh, Howard Kynaston, Alan Paul, Philip Powell, Stephen Prescott, Derek J Rosario, Edward Rowe, Michael Davis, Emma L Turner, Richard M Martin, David E Neal
Background Robust data on patient-reported outcome measures comparing treatments for clinically localized prostate cancer are lacking. We investigated the effects of active monitoring, radical prostatectomy, and radical radiotherapy with hormones on patient-reported outcomes. Methods We compared patient-reported outcomes among 1643 men in the Prostate Testing for Cancer and Treatment (ProtecT) trial who completed questionnaires before diagnosis, at 6 and 12 months after randomization, and annually thereafter...
October 13, 2016: New England Journal of Medicine
Melissa Thompson, Chris Henshall, Louis P Garrison, Adrian D Griffin, Doug Coyle, Stephen Long, Zayna A Khayat, Dana L Anger, Rebecca Yu
OBJECTIVES: To address the uncertainty associated with procuring pharmaceutical products, product listing agreements (PLAs) are increasingly being used to support responsible funding decisions in Canada and elsewhere. These agreements typically involve financial-based rebating initiatives or, less frequently, outcome-based contracts. A qualitative survey was conducted to improve the understanding of outcome-based and more innovative PLAs (IPLAs) based on input from Canadian and international key opinion leaders in the areas of drug manufacturing and reimbursement...
2016: ClinicoEconomics and Outcomes Research: CEOR
Arutha Kulasinghe, Chris Perry, Majid E Warkiani, Tony Blick, Anthony Davies, Ken O'Byrne, Erik W Thompson, Colleen C Nelson, Ian Vela, Chamindie Punyadeera
Minimally invasive techniques are required for the identification of head and neck cancer (HNC) patients who are at an increased risk of metastasis, or are not responding to therapy. An approach utilised in other solid cancers is the identification and enumeration of circulating tumour cells (CTCs) in the peripheral blood of patients. Low numbers of CTCs has been a limiting factor in the HNC field to date. Here we present a methodology to expand HNC patient derived CTCs ex-vivo. As a proof of principle study, 25 advanced stage HNC patient bloods were enriched for circulating tumour cells through negative selection and cultured in 2D and 3D culture environments under hypoxic conditions (2% O2, 5% CO2)...
August 9, 2016: Oncotarget
Caroline G Watts, Christine M Madronio, Rachael L Morton, Chris Goumas, Bruce K Armstrong, Austin Curtin, Scott W Menzies, Graham J Mann, John F Thompson, Anne E Cust
BACKGROUND/OBJECTIVES: To describe the method of diagnosis, clinical management and adherence to clinical practice guidelines for melanoma patients at high risk of a subsequent primary melanoma, and compare this with melanoma patients at lower risk. METHODS: The Melanoma Patterns of Care study was a population-based, observational study based on doctors' reported clinical management of melanoma patients in New South Wales, Australia, diagnosed with in situ or invasive melanoma over a 12-month period from October 2006...
August 1, 2016: Australasian Journal of Dermatology
Tassos Grammatikopoulos, Melissa Sambrotta, Sandra Strautnieks, Pierre Foskett, A S Knisely, Bart Wagner, Maesha Deheragoda, Chris Starling, Giorgina Mieli-Vergani, Joshua Smith, University Of Washington Center For Mendelian Genomics, Laura Bull, Richard J Thompson
BACKGROUND & AIMS: Neonatal sclerosing cholangitis (NSC) is a severe neonatal-onset cholangiopathy commonly leading to liver transplantation (LT) for end-stage liver disease in childhood. Liver-biopsy findings histopathologically resemble those in biliary atresia (BA); however, in NSC extrahepatic bile ducts are patent, whilst in BA their lumina are obliterated. NSC is commonly seen in consanguineous kindreds, suggesting autosomal recessive inheritance. METHODS: From 29 NSC patients (24 families) identified, DNA was available in 24 (21 families)...
July 25, 2016: Journal of Hepatology
Chris Thompson, Tariq Ismail, Simon Radley, Robert Walt, Stephen Thomas Ward
OBJECTIVE: To quantify the proportion of requests for colonoscopy that are performed as flexible sigmoidoscopy and documented reasons for this in ordinary UK hospital practice. To determine the effect these requests have on colonoscopy completion rate if they are included in the denominator of the calculated rate by individual endoscopist. DESIGN: Retrospective study of 22 months flexible sigmoidoscopy practice at a major UK teaching hospital. All flexible sigmoidoscopies performed had their associated request form examined...
July 2016: Frontline Gastroenterology
Johanna C Bendell, Todd M Bauer, Ruth Lamar, Mathew Joseph, William Penley, Dana S Thompson, David R Spigel, Rami Owera, Cassie M Lane, Chris Earwood, Howard A Burris
BACKGROUND: AUY922 is an inhibitor of heat shock protein 90 (Hsp90). Hsp90 inhibitors induce kit degradation in preclinical gastrointestinal stromal tumor (GIST) models. This trial was designed to determine the progression-free survival (PFS) of patients with GIST refractory to or intolerant of imatinib and sunitinib. METHODS: Eligible patients received AUY922 70 mg/mg(2) by intravenous (IV) infusion on days 1, 8, and 15 of 21-day cycles. Treatment continued until progression or unacceptable toxicity...
July 2, 2016: Cancer Investigation
Peter E Morris, Michael J Berry, D Clark Files, J Clifton Thompson, Jordan Hauser, Lori Flores, Sanjay Dhar, Elizabeth Chmelo, James Lovato, L Douglas Case, Rita N Bakhru, Aarti Sarwal, Selina M Parry, Pamela Campbell, Arthur Mote, Chris Winkelman, Robert D Hite, Barbara Nicklas, Arjun Chatterjee, Michael P Young
IMPORTANCE: Physical rehabilitation in the intensive care unit (ICU) may improve the outcomes of patients with acute respiratory failure. OBJECTIVE: To compare standardized rehabilitation therapy (SRT) to usual ICU care in acute respiratory failure. DESIGN, SETTING, AND PARTICIPANTS: Single-center, randomized clinical trial at Wake Forest Baptist Medical Center, North Carolina. Adult patients (mean age, 58 years; women, 55%) admitted to the ICU with acute respiratory failure requiring mechanical ventilation were randomized to SRT (n=150) or usual care (n=150) from October 2009 through May 2014 with 6-month follow-up...
June 28, 2016: JAMA: the Journal of the American Medical Association
Travis Saunders, Nerissa Campbell, Timothy Jason, Gail Dechman, Paul Hernandez, Kara Thompson, Chris M Blanchard
BACKGROUND: Although individual studies have reported on the number of steps/day taken by individuals with COPD, this evidence has not been systematically reviewed or synthesized. METHODS: MEDLINE and PsycINFO were searched for studies reporting objectively-measured steps/day and percent predicted forced expiratory volume in one second (FEV1%) in patients with COPD. Meta-analyses were used to estimate steps/day across studies, while meta-regression was used to estimate between-study variance based on clinical and demographic factors (year and location of study, activity monitor brand, number of days wearing the monitor, whether participants were about to enter pulmonary rehabilitation, 6 minute walk distance (6MWD), FEV1%, age, and sex)...
June 22, 2016: Journal of Physical Activity & Health
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