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JOURNAL ARTICLE
Breanne Mefford, Katie L Wallace, J Chris Donaldson, Brittany D Bissell Turpin, Parijat Sen, Aric D Schadler, Lucas J Liu, Melissa L Thompson Bastin
Piperacillin-tazobactam (TZP), cefepime (FEP), or meropenem (MEM) and vancomycin (VAN) are commonly used in combination for sepsis. Studies have shown an increased risk of acute kidney injury (AKI) with TZP and VAN compared to FEP or MEM. VAN guidelines recommend area under the curve (AUC) monitoring over trough (Tr) to minimize the risk of AKI. We investigated the association of AKI and MAKE-30 with the two VAN monitoring strategies when used in combination with TZP or FEP/MEM. Adult patients between 2015 and 2019 with VAN > 72 hours were included...
April 12, 2024: Antimicrobial Agents and Chemotherapy
#2
JOURNAL ARTICLE
Shelby E McIlroy, Isis Guibert, Anand Archana, Wing Yi Haze Chung, J Emmett Duffy, Rinaldi Gotama, Jerome Hui, Nancy Knowlton, Matthieu Leray, Chris Meyer, Gianni Panagiotou, Gustav Paulay, Bayden Russell, Philip D Thompson, David M Baker
Both human populations and marine biodiversity are concentrated along coastlines, with growing conservation interest in how these ecosystems can survive intense anthropogenic impacts. Tropical urban centres provide valuable research opportunities because these megacities are often adjacent to mega-diverse coral reef systems. The Pearl River Delta is a prime exemplar, as it encompasses one of the most densely populated and impacted regions in the world and is located just northwest of the Coral Triangle. However, the spatial and taxonomic complexity of this biodiversity, most of which is small, cryptic in habitat and poorly known, make comparative analyses challenging...
April 2024: Global Change Biology
#3
JOURNAL ARTICLE
Richard J Gilbertson, Sam Behjati, Anna-Lisa Böttcher, Marianne E Bronner, Matthew Burridge, Henrick Clausing, Harry Clifford, Tracey Danaher, Laura K Donovan, Jarno Drost, Alexander M M Eggermont, Chris Emerson, Mona G Flores, Petra Hamerlik, Nada Jabado, Andrew Jones, Henrick Kaessmann, Claudia L Kleinman, Marcel Kool, Lena M Kutscher, Gavin Lindberg, Emily Linnane, John C Marioni, John M Maris, Michelle Monje, Alexandra Macaskill, Steven Niederer, Paul A Northcott, Elizabeth Peeters, Willemijn Plieger-van Solkema, Liane Preußner, Anne C Rios, Karsten Rippe, Peter Sandford, Nikolaos G Sgourakis, Adam Shlien, Pete Smith, Karin Straathof, Patrick J Sullivan, Mario L Suvà, Michael D Taylor, Emma Thompson, Roser Vento-Tormo, Brandon J Wainwright, Robert J Wechsler-Reya, Frank Westermann, Shannon Winslade, Bissan Al-Lazikani, Stefan M Pfister
We are building the world's first Virtual Child-a computer model of normal and cancerous human development at the level of each individual cell. The Virtual Child will "develop cancer" that we will subject to unlimited virtual clinical trials that pinpoint, predict, and prioritize potential new treatments, bringing forward the day when no child dies of cancer, giving each one the opportunity to lead a full and healthy life.
April 4, 2024: Cancer Discovery
#4
JOURNAL ARTICLE
Dominick J Lemas, Xinsong Du, Masoud Rouhizadeh, Braeden Lewis, Simon Frank, Lauren Wright, Alex Spirache, Lisa Gonzalez, Ryan Cheves, Marina Magalhães, Ruben Zapata, Rahul Reddy, Ke Xu, Leslie Parker, Chris Harle, Bridget Young, Adetola Louis-Jaques, Bouri Zhang, Lindsay Thompson, William R Hogan, François Modave
The objective of this study is to develop and evaluate natural language processing (NLP) and machine learning models to predict infant feeding status from clinical notes in the Epic electronic health records system. The primary outcome was the classification of infant feeding status from clinical notes using Medical Subject Headings (MeSH) terms. Annotation of notes was completed using TeamTat to uniquely classify clinical notes according to infant feeding status. We trained 6 machine learning models to classify infant feeding status: logistic regression, random forest, XGBoost gradient descent, k-nearest neighbors, and support-vector classifier...
April 3, 2024: Scientific Reports
#5
JOURNAL ARTICLE
Stephanie Panzer, Alice Paladin, Stephanie Zesch, Wilfried Rosendahl, Peter Augat, Randall C Thompson, Michael I Miyamoto, M Linda Sutherland, Adel H Allam, L Samuel Wann, James D Sutherland, Chris J Rowan, David E Michalik, Klaus Hergan, Albert R Zink
The ancient Egyptians considered the heart to be the most important organ. The belief that the heart remained in the body is widespread in the archeological and paleopathological literature. The purpose of this study was to perform an overview of the preserved intrathoracic structures and thoracic and abdominal cavity filling, and to determine the prevalence and computed tomography (CT) characteristics of the myocardium in the preserved hearts of ancient Egyptian mummies. Whole-body CT examinations of 45 ancient Egyptian mummies (23 mummies from the Ägyptisches Museum und Papyrussammlung, Berlin, Germany, and 22 mummies from the Museo Egizio, Turin, Italy) were systematically assessed for preserved intrathoracic soft tissues including various anatomical components of the heart (pericardium, interventricular septum, four chambers, myocardium, valves)...
April 2, 2024: Clinical Anatomy
#6
JOURNAL ARTICLE
Rebekkah J Hitti-Malin, Daan M Panneman, Zelia Corradi, Erica G M Boonen, Galuh Astuti, Claire-Marie Dhaenens, Heidi Stöhr, Bernhard H F Weber, Dror Sharon, Eyal Banin, Marianthi Karali, Sandro Banfi, Tamar Ben-Yosef, Damjan Glavač, G Jane Farrar, Carmen Ayuso, Petra Liskova, Lubica Dudakova, Marie Vajter, Monika Ołdak, Jacek P Szaflik, Anna Matynia, Michael B Gorin, Kati Kämpjärvi, Miriam Bauwens, Elfride De Baere, Carel B Hoyng, Catherina H Z Li, Caroline C W Klaver, Chris F Inglehearn, Kaoru Fujinami, Carlo Rivolta, Rando Allikmets, Jana Zernant, Winston Lee, Osvaldo L Podhajcer, Ana Fakin, Jana Sajovic, Alaa AlTalbishi, Sandra Valeina, Gita Taurina, Andrea L Vincent, Lisa Roberts, Raj Ramesar, Giovanna Sartor, Elena Luppi, Susan M Downes, L Ingeborgh van den Born, Terri L McLaren, John N De Roach, Tina M Lamey, Jennifer A Thompson, Fred K Chen, Anna M Tracewska, Smaragda Kamakari, Juliana Maria Ferraz Sallum, Hanno J Bolz, Hülya Kayserili, Susanne Roosing, Frans P M Cremers
Inherited macular dystrophies (iMDs) are a group of genetic disorders, which affect the central region of the retina. To investigate the genetic basis of iMDs, we used single-molecule Molecular Inversion Probes to sequence 105 maculopathy-associated genes in 1352 patients diagnosed with iMDs. Within this cohort, 39.8% of patients were considered genetically explained by 460 different variants in 49 distinct genes of which 73 were novel variants, with some affecting splicing. The top five most frequent causative genes were ABCA4 (37...
March 19, 2024: Biomolecules
#7
JOURNAL ARTICLE
Jeffrey B Locke, Chris M Pillar, Mariana Castanheira, Cecilia G Carvalhaes, David Andes, Jalal A Aram, Christina Andrzejewski, Ken Bartizal, Anita F Das, Taylor Sandison, George R Thompson, Peter G Pappas
Rezafungin is a long-acting, intravenously administered echinocandin for the treatment of candidemia and invasive candidiasis (IC). Non-inferiority of rezafungin vs caspofungin for the treatment of adults with candidemia and/or IC was demonstrated in the Phase 3 ReSTORE study based on the primary endpoints of day 14 global cure and 30-day all-cause mortality. Here, an analysis of ReSTORE data evaluating efficacy outcomes by baseline Candida species is described. Susceptibility testing was performed for Candida species using the Clinical and Laboratory Standards Institute reference broth microdilution method...
March 25, 2024: Antimicrobial Agents and Chemotherapy
#8
JOURNAL ARTICLE
Chris L Adamson, Bonnie Alexander, Claire E Kelly, Gareth Ball, Richard Beare, Jeanie L Y Cheong, Alicia J Spittle, Lex W Doyle, Peter J Anderson, Marc L Seal, Deanne K Thompson
The delineation of cortical areas on magnetic resonance images (MRI) is important for understanding the complexities of the developing human brain. The previous version of the Melbourne Children's Regional Infant Brain (M-CRIB-S) (Adamson et al. Scientific Reports, 10(1), 10, 2020) is a software package that performs whole-brain segmentation, cortical surface extraction and parcellation of the neonatal brain. Available cortical parcellation schemes in the M-CRIB-S are the adult-compatible 34- and 31-region per hemisphere Desikan-Killiany (DK) and Desikan-Killiany-Tourville (DKT), respectively...
March 16, 2024: Neuroinformatics
#9
Bo-Gyeom Kim, Gakyung Kim, Yoshinari Abe, Pino Alonso, Stephanie Ameis, Alan Anticevic, Paul D Arnold, Srinivas Balachander, Nerisa Banaj, Nuria Bargalló, Marcelo C Batistuzzo, Francesco Benedetti, Sara Bertolín, Jan Carl Beucke, Irene Bollettini, Silvia Brem, Brian P Brennan, Jan K Buitelaar, Rosa Calvo, Miguel Castelo-Branco, Yuqi Cheng, Ritu Bhusal Chhatkuli, Valentina Ciullo, Ana Coelho, Beatriz Couto, Sara Dallaspezia, Benjamin A Ely, Sónia Ferreira, Martine Fontaine, Jean-Paul Fouche, Rachael Grazioplene, Patricia Gruner, Kristen Hagen, Bjarne Hansen, Gregory L Hanna, Yoshiyuki Hirano, Marcelo Q Höxter, Morgan Hough, Hao Hu, Chaim Huyser, Toshikazu Ikuta, Neda Jahanshad, Anthony James, Fern Jaspers-Fayer, Selina Kasprzak, Norbert Kathmann, Christian Kaufmann, Minah Kim, Kathrin Koch, Gerd Kvale, Jun Soo Kwon, Luisa Lazaro, Junhee Lee, Christine Lochner, Jin Lu, Daniela Rodriguez Manrique, Ignacio Martínez-Zalacaín, Yoshitada Masuda, Koji Matsumoto, Maria Paula Maziero, Jose M Menchón, Luciano Minuzzi, Pedro Silva Moreira, Pedro Morgado, Janardhanan C Narayanaswamy, Jin Narumoto, Ana E Ortiz, Junko Ota, Jose C Pariente, Chris Perriello, Maria Picó-Pérez, Christopher Pittenger, Sara Poletti, Eva Real, Y C Janardhan Reddy, Daan van Rooij, Yuki Sakai, João Ricardo Sato, Cinto Segalas, Roseli G Shavitt, Zonglin Shen, Eiji Shimizu, Venkataram Shivakumar, Noam Soreni, Carles Soriano-Mas, Nuno Sousa, Mafalda Machado Sousa, Gianfranco Spalletta, Emily R Stern, S Evelyn Stewart, Philip R Szeszko, Rajat Thomas, Sophia I Thomopoulos, Daniela Vecchio, Ganesan Venkatasubramanian, Chris Vriend, Susanne Walitza, Zhen Wang, Anri Watanabe, Lidewij Wolters, Jian Xu, Kei Yamada, Je-Yeon Yun, Mojtaba Zarei, Qing Zhao, Xi Zhu, Paul M Thompson, Willem B Bruin, Guido A van Wingen, Federica Piras, Fabrizio Piras, Dan J Stein, Odile A van den Heuvel, Helen Blair Simpson, Rachel Marsh, Jiook Cha
No abstract text is available yet for this article.
March 7, 2024: Molecular Psychiatry
#10
REVIEW
Jonah A Hoyt, Emily Cozzi, David A D'Alessio, Chris C Thompson, Vanita R Aroda
Affecting 5%-10% of the world population, type 2 diabetes (T2DM) is firmly established as one of the major health burdens of modern society. People with T2DM require long-term therapies to reduce blood glucose, an approach that can mitigate the vascular complications. However, fewer than half of those living with T2DM reach their glycaemic targets despite the availability of multiple oral and injectable medications. Adherence and access to medications are major barriers contributing to suboptimal diabetes treatment...
March 4, 2024: Diabetes, Obesity & Metabolism
#11
REVIEW
Debbie Kinsey, Daniele Carrieri, Simon Briscoe, Sam Febrey, Dylan Kneale, Chris Lovegrove, Michael Nunns, Jo Thompson Coon, John McGrath, Anthony Hemsley, Liz Shaw
BACKGROUND AND OBJECTIVES: Hospitals streamline treatment pathways to reduce the length of time older adults admitted for planned procedures spend in hospital. However patient perspectives have been poorly evaluated. This systematic review aimed to understand the experiences of older patients, carers, families and staff of multi-component interventions intended to improve recovery following elective treatment. RESEARCH DESIGN AND METHODS: Bibliographic databases searched in June 2021 included MEDLINE ALL, HMIC, CENTRAL, CINAHL, AMED and ProQuest Dissertations and Theses...
March 2024: International Journal of Older People Nursing
#12
JOURNAL ARTICLE
Suvi T Vaara, Ary Serpa Neto, Rinaldo Bellomo, Neill K J Adhikari, Didier Dreyfuss, Martin Gallagher, Stephane Gaudry, Eric Hoste, Michael Joannidis, Ville Pettilä, Amanda Y Wang, Kianoush Kashani, Ron Wald, Sean M Bagshaw, Marlies Ostermann
OBJECTIVES: Among patients with severe acute kidney injury (AKI) admitted to the ICU in high-income countries, regional practice variations for fluid balance (FB) management, timing, and choice of renal replacement therapy (RRT) modality may be significant. DESIGN: Secondary post hoc analysis of the STandard vs. Accelerated initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial (ClinicalTrials.gov number NCT02568722). SETTING: One hundred-fifty-three ICUs in 13 countries...
February 2024: Critical care explorations
#13
JOURNAL ARTICLE
Hayley S Clements, Emmanuel Do Linh San, Gareth Hempson, Birthe Linden, Bryan Maritz, Ara Monadjem, Chevonne Reynolds, Frances Siebert, Nicola Stevens, Reinette Biggs, Alta De Vos, Ryan Blanchard, Matthew Child, Karen J Esler, Maike Hamann, Ty Loft, Belinda Reyers, Odirilwe Selomane, Andrew L Skowno, Tshegofatso Tshoke, Diarrassouba Abdoulaye, Thierry Aebischer, Jesús Aguirre-Gutiérrez, Graham J Alexander, Abdullahi H Ali, David G Allan, Esther E Amoako, Samuel Angedakin, Edward Aruna, Nico L Avenant, Gabriel Badjedjea, Adama Bakayoko, Abraham Bamba-Kaya, Michael F Bates, Paul J J Bates, Steven R Belmain, Emily Bennitt, James Bradley, Chris A Brewster, Michael B Brown, Michelle Brown, Josef Bryja, Thomas M Butynski, Filipe Carvalho, Alan Channing, Colin A Chapman, Callan Cohen, Marina Cords, Jennifer D Cramer, Nadine Cronk, Pamela M K Cunneyworth, Fredrik Dalerum, Emmanuel Danquah, Harriet T Davies-Mostert, Andrew D de Blocq, Yvonne A De Jong, Terrence C Demos, Christiane Denys, Chabi A M S Djagoun, Thomas M Doherty-Bone, Marine Drouilly, Johan T du Toit, David A Ehlers Smith, Yvette C Ehlers Smith, Seth J Eiseb, Peter J Fashing, Adam W Ferguson, José M Fernández-García, Manfred Finckh, Claude Fischer, Edson Gandiwa, Philippe Gaubert, Jerome Y Gaugris, Dalton J Gibbs, Jason S Gilchrist, Jose M Gil-Sánchez, Anthony N Githitho, Peter S Goodman, Laurent Granjon, J Paul Grobler, Bonginkosi C Gumbi, Vaclav Gvozdik, James Harvey, Morgan Hauptfleisch, Firas Hayder, Emmanuel M Hema, Marna Herbst, Mariano Houngbédji, Brian J Huntley, Rainer Hutterer, Samuel T Ivande, Kate Jackson, Gregory F M Jongsma, Javier Juste, Blaise Kadjo, Prince K Kaleme, Edwin Kamugisha, Beth A Kaplin, Humphrey N Kato, Christian Kiffner, Duncan M Kimuyu, Robert M Kityo, N'goran G Kouamé, Marcel Kouete T, Aliza le Roux, Alan T K Lee, Mervyn C Lötter, Anne Mette Lykke, Duncan N MacFadyen, Gacheru P Macharia, Zimkitha J K Madikiza, Themb'alilahlwa A M Mahlaba, David Mallon, Mnqobi L Mamba, Claude Mande, Rob A Marchant, Robin A Maritz, Wanda Markotter, Trevor McIntyre, John Measey, Addisu Mekonnen, Paulina Meller, Haemish I Melville, Kevin Z Mganga, Michael G L Mills, Liaan Minnie, Alain Didier Missoup, Abubakr Mohammad, Nancy N Moinde, Bakwo Fils E Moise, Pedro Monterroso, Jennifer F Moore, Simon Musila, Sedjro Gilles A Nago, Maganizo W Namoto, Fatimata Niang, Violaine Nicolas, Jerry B Nkenku, Evans E Nkrumah, Gonwouo L Nono, Mulavwa M Norbert, Katarzyna Nowak, Benneth C Obitte, Arnold D Okoni-Williams, Jonathan Onongo, M Justin O'Riain, Samuel T Osinubi, Daniel M Parker, Francesca Parrini, Mike J S Peel, Johannes Penner, Darren W Pietersen, Andrew J Plumptre, Damian W Ponsonby, Stefan Porembski, R John Power, Frans G T Radloff, Ramugondo V Rambau, Tharmalingam Ramesh, Leigh R Richards, Mark-Oliver Rödel, Dominic P Rollinson, Francesco Rovero, Mostafa A Saleh, Ute Schmiedel, M Corrie Schoeman, Paul Scholte, Thomas L Serfass, Julie Teresa Shapiro, Sidney Shema, Stefan J Siebert, Jasper A Slingsby, Alexander Sliwa, Hanneline A Smit-Robinson, Etotepe A Sogbohossou, Michael J Somers, Stephen Spawls, Jarryd P Streicher, Lourens Swanepoel, Iroro Tanshi, Peter J Taylor, William A Taylor, Mariska Te Beest, Paul T Telfer, Dave I Thompson, Elie Tobi, Krystal A Tolley, Andrew A Turner, Wayne Twine, Victor Van Cakenberghe, Frederik Van de Perre, Helga van der Merwe, Chris J G van Niekerk, Pieter C V van Wyk, Jan A Venter, Luke Verburgt, Geraldine Veron, Susanne Vetter, Maria S Vorontsova, Thomas C Wagner, Paul W Webala, Natalie Weber, Sina M Weier, Paula A White, Melissa A Whitecross, Benjamin J Wigley, Frank J Willems, Christiaan W Winterbach, Galena M Woodhouse
Sub-Saharan Africa is under-represented in global biodiversity datasets, particularly regarding the impact of land use on species' population abundances. Drawing on recent advances in expert elicitation to ensure data consistency, 200 experts were convened using a modified-Delphi process to estimate 'intactness scores': the remaining proportion of an 'intact' reference population of a species group in a particular land use, on a scale from 0 (no remaining individuals) to 1 (same abundance as the reference) and, in rare cases, to 2 (populations that thrive in human-modified landscapes)...
February 12, 2024: Scientific Data
#14
JOURNAL ARTICLE
Zachary Abramson, Dylan Thompson, Chris Goode, Cara E Morin, Sarah Daniels, Asim F Choudhri, Andrew M Davidoff
As the field of three-dimensional (3D) visualization rapidly advances, how healthcare professionals perceive and interact with real and virtual objects becomes increasingly complex. Lack of clear vocabulary to navigate the changing landscape of 3D visualization hinders clinical and scientific advancement, particularly within the field of radiology. In this article, we provide foundational definitions and illustrative examples for 3D visualization in clinical care, with a focus on the pediatric patient population...
February 9, 2024: Pediatric Radiology
#15
JOURNAL ARTICLE
Bo-Gyeom Kim, Gakyung Kim, Yoshinari Abe, Pino Alonso, Stephanie Ameis, Alan Anticevic, Paul D Arnold, Srinivas Balachander, Nerisa Banaj, Nuria Bargalló, Marcelo C Batistuzzo, Francesco Benedetti, Sara Bertolín, Jan Carl Beucke, Irene Bollettini, Silvia Brem, Brian P Brennan, Jan K Buitelaar, Rosa Calvo, Miguel Castelo-Branco, Yuqi Cheng, Ritu Bhusal Chhatkuli, Valentina Ciullo, Ana Coelho, Beatriz Couto, Sara Dallaspezia, Benjamin A Ely, Sónia Ferreira, Martine Fontaine, Jean-Paul Fouche, Rachael Grazioplene, Patricia Gruner, Kristen Hagen, Bjarne Hansen, Gregory L Hanna, Yoshiyuki Hirano, Marcelo Q Höxter, Morgan Hough, Hao Hu, Chaim Huyser, Toshikazu Ikuta, Neda Jahanshad, Anthony James, Fern Jaspers-Fayer, Selina Kasprzak, Norbert Kathmann, Christian Kaufmann, Minah Kim, Kathrin Koch, Gerd Kvale, Jun Soo Kwon, Luisa Lazaro, Junhee Lee, Christine Lochner, Jin Lu, Daniela Rodriguez Manrique, Ignacio Martínez-Zalacaín, Yoshitada Masuda, Koji Matsumoto, Maria Paula Maziero, Jose M Menchón, Luciano Minuzzi, Pedro Silva Moreira, Pedro Morgado, Janardhanan C Narayanaswamy, Jin Narumoto, Ana E Ortiz, Junko Ota, Jose C Pariente, Chris Perriello, Maria Picó-Pérez, Christopher Pittenger, Sara Poletti, Eva Real, Y C Janardhan Reddy, Daan van Rooij, Yuki Sakai, João Ricardo Sato, Cinto Segalas, Roseli G Shavitt, Zonglin Shen, Eiji Shimizu, Venkataram Shivakumar, Carles Soriano-Mas, Nuno Sousa, Mafalda Machado Sousa, Gianfranco Spalletta, Emily R Stern, S Evelyn Stewart, Philip R Szeszko, Rajat Thomas, Sophia I Thomopoulos, Daniela Vecchio, Ganesan Venkatasubramanian, Chris Vriend, Susanne Walitza, Zhen Wang, Anri Watanabe, Lidewij Wolters, Jian Xu, Kei Yamada, Je-Yeon Yun, Mojtaba Zarei, Qing Zhao, Xi Zhu, Paul M Thompson, Willem B Bruin, Guido A van Wingen, Federica Piras, Fabrizio Piras, Dan J Stein, Odile A van den Heuvel, Helen Blair Simpson, Rachel Marsh, Jiook Cha
White matter pathways, typically studied with diffusion tensor imaging (DTI), have been implicated in the neurobiology of obsessive-compulsive disorder (OCD). However, due to limited sample sizes and the predominance of single-site studies, the generalizability of OCD classification based on diffusion white matter estimates remains unclear. Here, we tested classification accuracy using the largest OCD DTI dataset to date, involving 1336 adult participants (690 OCD patients and 646 healthy controls) and 317 pediatric participants (175 OCD patients and 142 healthy controls) from 18 international sites within the ENIGMA OCD Working Group...
February 7, 2024: Molecular Psychiatry
#16
JOURNAL ARTICLE
Paul M Salmon, Scott McLean, Tony Carden, Brandon J King, Jason Thompson, Chris Baber, Neville A Stanton, Gemma J M Read
There are concerns that Artificial General Intelligence (AGI) could pose an existential threat to humanity; however, as AGI does not yet exist it is difficult to prospectively identify risks and develop requisite controls. We applied the Work Domain Analysis Broken Nodes (WDA-BN) and Event Analysis of Systemic Teamwork-Broken Links (EAST-BL) methods to identify potential risks in a future 'envisioned world' AGI-based uncrewed combat aerial vehicle system. The findings suggest five main categories of risk in this context: sub-optimal performance risks, goal alignment risks, super-intelligence risks, over-control risks, and enfeeblement risks...
February 5, 2024: Applied Ergonomics
#17
JOURNAL ARTICLE
Nasya Thompson, Chris Frampton, Giovanni Losco
AIMS: To assess the outcomes of patients with haematuria from radiation cystitis admitted to Christchurch Hospital's Urology Service and identify treatment differences and hospitalisation trends. METHODS: From November 2021 to January 2023, a retrospective analysis of 144 acute haematuria admissions was conducted. Data covered demographics, diagnosis, surgeries, complications and hospital stay length. Predictive factors for admissions and surgical interventions were explored...
February 2, 2024: New Zealand Medical Journal
#18
JOURNAL ARTICLE
Karoline Freeman, Alice Mansbridge, Hilary Stobart, Karen Clements, Matthew G Wallis, Sarah E Pinder, Olive Kearins, Abeer M Shaaban, Cliona C Kirwan, Louise S Wilkinson, Sharon Webb, Emma O'Sullivan, Jacquie Jenkins, Suzanne Wright, Kathryn Taylor, Claire Bailey, Chris Holcombe, Lynda Wyld, Kim Edwards, David J Jenkinson, Nisha Sharma, Elena Provenzano, Bridget Hilton, Nigel Stallard, Alastair M Thompson, Sian Taylor-Phillips
Evidence-based clinical guidelines are essential to maximize patient benefit and to reduce clinical uncertainty and inconsistency in clinical practice. Gaps in the evidence base can be addressed by data acquired in routine practice. At present, there is no international consensus on management of women diagnosed with atypical lesions in breast screening programmes. Here, we describe how routine NHS breast screening data collected by the Sloane atypia project was used to inform a management pathway that maximizes early detection of cancer and minimizes over-investigation of lesions with uncertain malignant potential...
December 20, 2023: British Journal of Radiology
#19
JOURNAL ARTICLE
Stephen A Kelly, Nuala H O'Connell, Thomas P Thompson, Lucy Dillon, Jiaqi Wu, Chris Creevey, James Powell, Brendan F Gilmore, Colum P Dunne
Reports of nosocomial infections typically describe recognised microorganisms. In this study, a novel bacterial species was isolated, based on rectal swab screening for carbapenemases post-admission, then phenotypically and genetically characterised. Determined to be a possible Enterobacterales, whole genome sequencing and phylogenetic analysis confirmed identification as Pseudocitrobacter, a relatively new genus (2013) with three known species. This isolate was found to be distinct from these, with 99.7% 16s rRNA identity to Pseudocitrobacter corydidari; an Asian cockroach-associated species...
January 10, 2024: Journal of Hospital Infection
#20
JOURNAL ARTICLE
Caitlin Wheeler, John K Pearman, Jamie D Howarth, Marcus J Vandergoes, Katherine Holt, Steven A Trewick, Xun Li, Lucy Thompson, Georgia Thomson-Laing, Mailys Picard, Chris Moy, Nicholas P Mckay, Adelaine Moody, Claire Shepherd, Valerie van den Bos, Konstanze Steiner, Susanna A Wood
Cyanobacterial blooms are one of the most significant threats to global water security and freshwater biodiversity. Interactions among multiple stressors, including habitat degradation, species invasions, increased nutrient runoff, and climate change, are key drivers. However, assessing the role of anthropogenic activity on the onset of cyanobacterial blooms and exploring response variation amongst lakes of varying size and depth is usually limited by lack of historical records. In the present study we applied molecular, paleolimnological (trace metal, Itrax-µ-XRF and hyperspectral scanning, chronology), paleobotanical (pollen) and historical data to reconstruct cyanobacterial abundance and community composition and anthropogenic impacts in two dune lakes over a period of up to 1200 years...
January 2024: Harmful Algae
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