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Norwood variation

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https://www.readbyqxmd.com/read/27879470/incidence-and-management-of-thrombotic-and-thromboembolic-complications-following-the-norwood-procedure-a-systematic-review
#1
Arnav Agarwal, Mohammed Firdouse, Nishaan Brar, Andy Yang, Panos Lambiris, Anthony K Chan, Tapas K Mondal
BACKGROUND: The stage 1 Norwood procedure and its variants represent the first step of palliation for hypoplastic left heart syndrome. Although appropriate postoperative thromboprophylaxis is integral, significant variance remains across institutional practices. The purpose of this systematic review is to estimate the incidence of thrombosis and thromboembolism following the Norwood or modified Blalock-Taussig shunt procedure and examine current thromboprophylaxis regimens. METHODS: Ovid MEDLINE and Embase were searched from January 2000 to June 2016 for primary studies explicitly reporting incidence of thrombosis, thromboembolism (strokes and pulmonary embolisms), or shunt occlusion in neonates, infants, and children undergoing the Norwood procedure or any variant...
November 21, 2016: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/27314231/parasite-community-similarity-in-athabasca-river-trout-perch-percopsis-omiscomaycus-varies-with-local-scale-land-use-and-sediment-hydrocarbons-but-not-distance-or-linear-gradients
#2
C A Blanar, M Hewitt, M McMaster, J Kirk, Z Wang, W Norwood, D J Marcogliese
Parasite communities have been shown to be structured by processes at scales ranging from continental to microhabitat, but few studies have simultaneously considered spatial and environmental variables, measured at different scales, to assess their relative influences on parasite abundance, species richness, and community similarity. Parasite abundance, diversity, and community similarity in Athabasca River trout-perch (Percopsis omiscomaycus) were examined in relation to water quality, substrate profile, metal and organic compound levels in water and sediment, and landscape use patterns at different scales, as well as distance among sites and upstream-downstream position along the river...
October 2016: Parasitology Research
https://www.readbyqxmd.com/read/27266873/estimating-micro-area-behavioural-risk-factor-prevalence-from-large-population-based-surveys-a-full-bayesian-approach
#3
L Seliske, T A Norwood, J R McLaughlin, S Wang, C Palleschi, E Holowaty
BACKGROUND: An important public health goal is to decrease the prevalence of key behavioural risk factors, such as tobacco use and obesity. Survey information is often available at the regional level, but heterogeneity within large geographic regions cannot be assessed. Advanced spatial analysis techniques are demonstrated to produce sensible micro area estimates of behavioural risk factors that enable identification of areas with high prevalence. METHODS: A spatial Bayesian hierarchical model was used to estimate the micro area prevalence of current smoking and excess bodyweight for the Erie-St...
2016: BMC Public Health
https://www.readbyqxmd.com/read/27037714/state-policy-environment-and-the-dental-safety-net-a-case-study-of-professional-practice-environments-effect-on-dental-service-availability-in-federally-qualified-health-centers
#4
Hannah L Maxey, Connor W Norwood, Ziyue Liu
OBJECTIVES: To determine whether and to what extent the state policy environment for the dental hygiene workforce affects the availability of dental services at Federally Qualified Health Centers (FQHCs). METHODS: We examined data drawn from the Uniform Data System on 1,135 unique FQHC grantees receiving community health center funding from the U.S. Health Center program between 2004 and 2012. The Dental Hygiene Professional Practice Index was used to quantify variations in state policy environment...
April 1, 2016: Journal of Public Health Dentistry
https://www.readbyqxmd.com/read/26233275/influence-of-morphology-and-initial-surgical-strategy-on-survival-of-infants-with-tricuspid-atresia
#5
Bahaaldin Alsoufi, Brian Schlosser, Makoto Mori, Courtney McCracken, Timothy Slesnick, Brian Kogon, Christopher Petit, Ritu Sachdeva, Kirk Kanter
BACKGROUND: Tricuspid atresia (TA) is a heterogeneous single-ventricle anomaly in which initial presentation and, consequently, timing and mode of palliation vary based on morphology and degree of pulmonary or systemic outflow obstruction. We report current era palliation outcomes and examine whether morphologic and, subsequently, surgical factors influence survival. METHODS: From 2002 to 2012, 105 infants with TA underwent surgical palliation. Competing risks analyses modeled events after first-stage surgery (Glenn versus death) and after Glenn (Fontan versus death) and examined risk factors affecting outcomes...
October 2015: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/26208236/quality-improvement-through-collaboration-the-national-pediatric-quality-improvement-collaborative-initiative
#6
REVIEW
Sarah B Clauss, Jeffrey B Anderson, Carole Lannon, Stacey Lihn, Robert H Beekman, John D Kugler, Gerard R Martin
PURPOSE OF REVIEW: The National Pediatric Quality Improvement Collaborative (NPCQIC) was established to improve outcomes and quality of life in children with hypoplastic left heart syndrome and other single ventricle lesions requiring a Norwood operation. The NPCQIC consists of a network of providers and families collecting longitudinal data, conducting research, and using quality improvement science to decrease variations in care, develop and spread best practices, and decrease mortality...
October 2015: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/26169083/the-norwood-operation-relative-effects-of-surgeon-and-institutional-volumes-on-outcomes-and-resource-utilization
#7
Brett R Anderson, Adam J Ciarleglio, David J Cohen, Wyman W Lai, Matthew Neidell, Matthew Hall, Sherry A Glied, Emile A Bacha
BACKGROUND: Hypoplastic left heart syndrome is the most expensive birth defect managed in the United States, with a 5-year survival rate below 70%. Increasing evidence suggests that hospital volumes are inversely associated with mortality for infants with single ventricles undergoing stage 1 surgical palliation. Our aim was to examine the relative effects of surgeon and institutional volumes on outcomes and resource utilisation for these children. METHODS: A retrospective study was conducted using the Pediatric Health Information System database to examine the effects of the number of procedures performed per surgeon and per centre on mortality, costs, and post-operative length of stay for infants undergoing Risk Adjustment for Congenital Heart Surgery risk category six operations at tertiary-care paediatric hospitals, from 1 January, 2004 to 31 December, 2013...
April 2016: Cardiology in the Young
https://www.readbyqxmd.com/read/25710889/evaluation-of-virocyt%C3%A2-virus-counter-for-rapid-filovirus-quantitation
#8
Cynthia A Rossi, Brian J Kearney, Scott P Olschner, Priscilla L Williams, Camenzind G Robinson, Megan L Heinrich, Ashley M Zovanyi, Michael F Ingram, David A Norwood, Randal J Schoepp
Development and evaluation of medical countermeasures for diagnostics, vaccines, and therapeutics requires production of standardized, reproducible, and well characterized virus preparations. For filoviruses this includes plaque assay for quantitation of infectious virus, transmission electron microscopy (TEM) for morphology and quantitation of virus particles, and real-time reverse transcription PCR for quantitation of viral RNA (qRT-PCR). The ViroCyt® Virus Counter (VC) 2100 (ViroCyt, Boulder, CO, USA) is a flow-based instrument capable of quantifying virus particles in solution...
March 2015: Viruses
https://www.readbyqxmd.com/read/25358553/use-of-a-learning-network-to-improve-variation-in-interstage-weight-gain-after-the-norwood-operation
#9
MULTICENTER STUDY
Jeffrey B Anderson, Robert H Beekman, John D Kugler, Geoffrey L Rosenthal, Kathy J Jenkins, Thomas S Klitzner, Gerard R Martin, Steven R Neish, Lynn Darbie, Eileen King, Carole Lannon
BACKGROUND: Growth failure is common in infants with single ventricle. This study evaluated the use of a learning network, the National Pediatric Cardiology Quality Improvement Collaborative (NPC-QIC), to spread optimized nutritional practices and improve infant growth. METHODS: A previously identified Nutritional Bundle was spread among NPC-QIC sites. PRIMARY OUTCOME: interstage weight-for-age z-score change (ΔWAZ) between discharge from stage 1 palliation (S1) and stage 2 surgical palliation (S2)...
November 2014: Congenital Heart Disease
https://www.readbyqxmd.com/read/25204361/similar-response-patterns-to-topical-minoxidil-foam-5-in-frontal-and-vertex-scalp-of-men-with-androgenetic-alopecia-a-microarray-analysis
#10
P Mirmirani, M Consolo, P Oyetakin-White, E Baron, P Leahy, P Karnik
BACKGROUND: There are regional variations in the scalp hair miniaturization seen in androgenetic alopecia (AGA). Use of topical minoxidil can lead to reversal of miniaturization in the vertex scalp. However, its effects on other scalp regions have been less well studied. OBJECTIVES: To determine whether scalp biopsies from men with AGA show variable gene expression before and after 8 weeks of treatment with minoxidil topical foam 5% (MTF) vs. placebo. METHODS: A placebo-controlled double-blinded prospective pilot study of MTF vs...
June 2015: British Journal of Dermatology
https://www.readbyqxmd.com/read/24977855/structure-based-optical-filtering-by-the-silica-microshell-of-the-centric-marine-diatom-coscinodiscus-wailesii
#11
K Kieu, C Li, Y Fang, G Cohoon, O D Herrera, M Hildebrand, K H Sandhage, R A Norwood
Diatoms are a renewable (biologically reproducible) source of three-dimensional (3-D) nanostructured silica that could be attractive for a variety of photonic devices, owing to the wide range of quasi-periodic patterns of nano-to-microscale pores available on the silica microshells (frustules) of various diatom species. We have investigated the optical behavior of the silica frustule of a centric marine diatom, Coscinodiscus wailesii, using a coherent broadband (400-1700 nm) supercontinuum laser focused to a fine (20 µm diameter) spot...
June 30, 2014: Optics Express
https://www.readbyqxmd.com/read/24952712/factors-associated-with-neurodevelopment-for-children-with-single-ventricle-lesions
#12
RANDOMIZED CONTROLLED TRIAL
Caren S Goldberg, Minmin Lu, Lynn A Sleeper, William T Mahle, J William Gaynor, Ismee A Williams, Kathleen A Mussatto, Richard G Ohye, Eric M Graham, Deborah U Frank, Jeffrey P Jacobs, Catherine Krawczeski, Linda Lambert, Alan Lewis, Victoria L Pemberton, Renee Sananes, Erica Sood, Stephanie B Wechsler, David C Bellinger, Jane W Newburger
OBJECTIVE: To measure neurodevelopment at 3 years of age in children with single right-ventricle anomalies and to assess its relationship to Norwood shunt type, neurodevelopment at 14 months of age, and patient and medical factors. STUDY DESIGN: All subjects in the Single Ventricle Reconstruction Trial who were alive without cardiac transplant were eligible for inclusion. The Ages and Stages Questionnaire (ASQ, n = 203) and other measures of behavior and quality of life were completed at age 3 years...
September 2014: Journal of Pediatrics
https://www.readbyqxmd.com/read/24906601/the-effect-of-modified-blalock-taussig-shunt-size-and-coarctation-severity-on-coronary-perfusion-after-the-norwood-operation
#13
Chiara Corsini, Giovanni Biglino, Silvia Schievano, Tain-Yen Hsia, Francesco Migliavacca, Giancarlo Pennati, Andrew M Taylor
BACKGROUND: The size of the modified Blalock-Taussig shunt and the additional presence of aortic coarctation can affect the hemodynamics of the Norwood physiology. Multiscale modeling was used to gather insight into the effects of these variables, in particular on coronary perfusion. METHODS: A model was reconstructed from cardiac magnetic resonance imaging data of a representative patient, and then simplified with computer-aided design software. Changes were systematically imposed to the semi-idealized three-dimensional model, resulting in a family of nine models (3-, 3...
August 2014: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/24894896/surgical-volume-to-outcome-relationship-and-monitoring-of-technical-performance-in-pediatric-cardiac-surgery
#14
REVIEW
David Kalfa, Paul Chai, Emile Bacha
A significant inverse relationship of surgical institutional and surgeon volumes to outcome has been demonstrated in many high-stakes surgical specialties. By and large, the same results were found in pediatric cardiac surgery, for which a more thorough analysis has shown that this relationship depends on case complexity and type of surgical procedures. Lower-volume programs tend to underperform larger-volume programs as case complexity increases. High-volume pediatric cardiac surgeons also tend to have better results than low-volume surgeons, especially at the more complex end of the surgery spectrum (e...
August 2014: Pediatric Cardiology
https://www.readbyqxmd.com/read/24567024/variation-in-congenital-heart-surgery-costs-across-hospitals
#15
COMPARATIVE STUDY
Sara K Pasquali, Marshall L Jacobs, Xia He, Samir S Shah, Eric D Peterson, Matthew Hall, J William Gaynor, Kevin D Hill, John E Mayer, Jeffrey P Jacobs, Jennifer S Li
BACKGROUND: A better understanding of costs associated with common and resource-intense conditions such as congenital heart disease has become increasingly important as children's hospitals face growing pressure to both improve quality and reduce costs. We linked clinical information from a large registry with resource utilization data from an administrative data set to describe costs for common congenital cardiac operations and assess variation across hospitals. METHODS: Using linked data from The Society of Thoracic Surgeons and Pediatric Health Information Systems Databases (2006-2010), estimated costs/case for 9 operations of varying complexity were calculated...
March 2014: Pediatrics
https://www.readbyqxmd.com/read/24246548/perioperative-mechanical-circulatory-support-in-children-an-analysis-of-the-society-of-thoracic-surgeons-congenital-heart-surgery-database
#16
MULTICENTER STUDY
Christopher E Mascio, Erle H Austin, Jeffrey P Jacobs, Marshall L Jacobs, Amelia S Wallace, Xia He, Sara K Pasquali
OBJECTIVES: Analyses of mechanical circulatory support (MCS) in pediatric heart surgery have primarily focused on single-center outcomes or narrow applications. We describe the patterns of use, patient characteristics, and MCS-associated outcomes across a large multicenter cohort. METHODS: Patients (aged <18 years) in the Society of Thoracic Surgeons (STS) Congenital Heart Surgery Database (2000-2010) were included. The characteristics and outcomes of those receiving postoperative MCS were described, and bayesian hierarchical models were used to examine variations in the adjusted MCS rates across institutions...
February 2014: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/24210923/variation-in-feeding-practices-following-the-norwood-procedure
#17
RANDOMIZED CONTROLLED TRIAL
Linda M Lambert, Nancy A Pike, Barbara Medoff-Cooper, Victor Zak, Victoria L Pemberton, Lisa Young-Borkowski, Martha L Clabby, Kathryn N Nelson, Richard G Ohye, Bethany Trainor, Karen Uzark, Nancy Rudd, Louise Bannister, Rosalind Korsin, David S Cooper, Christian Pizarro, Sinai C Zyblewski, Bronwyn H Bartle, Richard V Williams
OBJECTIVES: To assess variation in feeding practice at hospital discharge after the Norwood procedure, factors associated with tube feeding, and associations among site, feeding mode, and growth before stage II. STUDY DESIGN: From May 2005 to July 2008, 555 subjects from 15 centers were enrolled in the Pediatric Heart Network Single Ventricle Reconstruction Trial; 432 survivors with feeding data at hospital discharge after the Norwood procedure were analyzed. RESULTS: Demographic and clinical variables were compared among 4 feeding modes: oral only (n = 140), oral/tube (n = 195), nasogastric tube (N-tube) only (n = 40), and gastrostomy tube (G-tube) only (n = 57)...
February 2014: Journal of Pediatrics
https://www.readbyqxmd.com/read/24180032/-variation-of-the-norwood-procedure-using-a-rv-pa-conduit-method-for-left-heart-hypoplastic-syndrome
#18
Hidefumi Kishimoto
No abstract text is available yet for this article.
February 2013: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/23606733/hereditary-myopathy-with-early-respiratory-failure-occurrence-in-various-populations
#19
Johanna Palmio, Anni Evilä, Françoise Chapon, Giorgio Tasca, Fengqing Xiang, Björn Brådvik, Bruno Eymard, Andoni Echaniz-Laguna, Jocelyn Laporte, Mikko Kärppä, Ibrahim Mahjneh, Rosaline Quinlivan, Pascal Laforêt, Maxwell Damian, Andres Berardo, Ana Lia Taratuto, Jose Antonio Bueri, Johanna Tommiska, Taneli Raivio, Matthias Tuerk, Philipp Gölitz, Frederic Chevessier, Caroline Sewry, Fiona Norwood, Carola Hedberg, Rolf Schröder, Lars Edström, Anders Oldfors, Peter Hackman, Bjarne Udd
OBJECTIVE: Several families with characteristic features of hereditary myopathy with early respiratory failure (HMERF) have remained without genetic cause. This international study was initiated to clarify epidemiology and the genetic underlying cause in these families, and to characterise the phenotype in our large cohort. METHODS: DNA samples of all currently known families with HMERF without molecular genetic cause were obtained from 12 families in seven different countries...
March 2014: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/23606453/ano5-gene-analysis-in-a-large-cohort-of-patients-with-anoctaminopathy-confirmation-of-male-prevalence-and-high-occurrence-of-the-common-exon-5-gene-mutation
#20
Anna Sarkozy, Debbie Hicks, Judith Hudson, Steve H Laval, Rita Barresi, David Hilton-Jones, Marcus Deschauer, Elizabeth Harris, Laura Rufibach, Esther Hwang, Rumaisa Bashir, Maggie C Walter, Sabine Krause, Peter van den Bergh, Isabel Illa, Isabelle Pénisson-Besnier, Liesbeth De Waele, Doug Turnbull, Michela Guglieri, Bertold Schrank, Benedikt Schoser, Jürgen Seeger, Herbert Schreiber, Dieter Gläser, Michelle Eagle, Geraldine Bailey, Richard Walters, Cheryl Longman, Fiona Norwood, John Winer, Francesco Muntoni, Michael Hanna, Mark Roberts, Laurence A Bindoff, Charlotte Brierley, Robert G Cooper, David A Cottrell, Nick P Davies, Andrew Gibson, Gráinne S Gorman, Simon Hammans, Andrew P Jackson, Aijaz Khan, Russell Lane, John McConville, Meriel McEntagart, Ali Al-Memar, John Nixon, Jay Panicker, Matt Parton, Richard Petty, Christopher J Price, Wojtek Rakowicz, Partha Ray, Anthony H Schapira, Robert Swingler, Chris Turner, Kathryn R Wagner, Paul Maddison, Pamela J Shaw, Volker Straub, Kate Bushby, Hanns Lochmüller
Limb girdle muscular dystrophy type 2L or anoctaminopathy is a condition mainly characterized by adult onset proximal lower limb muscular weakness and raised CK values, due to recessive ANO5 gene mutations. An exon 5 founder mutation (c.191dupA) has been identified in most of the British and German LGMD2L patients so far reported. We aimed to further investigate the prevalence and spectrum of ANO5 gene mutations and related clinical phenotypes, by screening 205 undiagnosed patients referred to our molecular service with a clinical suspicion of anoctaminopathy...
August 2013: Human Mutation
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