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https://www.readbyqxmd.com/read/28435395/prevention-of-pancreatic-cancer
#1
REVIEW
Stefan Kuroczycki-Saniutycz, Agnieszka Grzeszczuk, Zbigniew Wojciech Zwierz, Paweł Kołodziejczyk, Jakub Szczesiul, Beata Zalewska-Szajda, Krystyna Ościłowicz, Napoleon Waszkiewicz, Krzysztof Zwierz, Sławomir Dariusz Szajda
Pancreatic ductal adenocarcinoma (PDA) accounts for 95% of all pancreatic cancers. About 230,000 PDA cases are diagnosed worldwide each year. PDA has the lowest five-year survival rate as compared to others cancers. PDA in Poland is the fifth leading cause of death after lung, stomach, colon and breast cancer. In our paper we have analysed the newest epidemiological research, some of it controversial, to establish the best practical solution for pancreatic cancer prevention in the healthy population as well as treatment for patients already diagnosed with pancreatic cancer...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/28431964/microvillus-specific-protein-tyrosine-phosphatase-sap-1-plays-a-role-in-regulating-the-intestinal-paracellular-transport-of-macromolecules
#2
Shingo Mori, Noriyasu Kamei, Yoji Murata, Kozo Takayama, Takashi Matozaki, Mariko Takeda-Morishita
The stomach cancer associated protein tyrosine phosphatase 1 (SAP-1) is a receptor-type protein tyrosine phosphatase that is specifically expressed on the apical membrane of the intestinal epithelium. SAP-1 is known to maintain the balance of phosphorylation of proteins together with protein kinases, however, its biological function and impact on pharmacokinetics in the intestine remain unclear. The present study, therefore, aimed to clarify the relationship between SAP-1 and the intestinal absorption behaviors of typical transporter substrates and macromolecules...
April 18, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28389380/etumortype-an-algorithm-of-discriminating-cancer-types-for-circulating-tumor-cells-or-cell-free-dnas-in-blood
#3
Jinfeng Zou, Edwin Wang
With the technology development on detecting circulating tumor cells (CTCs) and cell-free DNAs (cfDNAs) in blood, serum, and plasma, non-invasive diagnosis of cancer becomes promising. A few studies reported good correlations between signals from tumor tissues and CTCs or cfDNAs, making it possible to detect cancers using CTCs and cfDNAs. However, the detection cannot tell which cancer types the person has. To meet these challenges, we developed an algorithm, eTumorType, to identify cancer types based on copy number variations (CNVs) of the cancer founding clone...
April 4, 2017: Genomics, Proteomics & Bioinformatics
https://www.readbyqxmd.com/read/28382188/an-updated-review-of-cribriform-carcinomas-with-emphasis-on-histopathological-diagnosis-and-prognostic-significance
#4
REVIEW
Giovanni Branca, Antonio Ieni, Valeria Barresi, Giovanni Tuccari, Rosario Alberto Caruso
Cribriform is a histopathological term used to describe a neoplastic epithelial proliferation in the form of large nests perforated by many quite rounded different-sized spaces. This growth pattern may be seen in carcinomas arising in different organs, and shows important prognostic implications. Therefore, recent data in literature suggest that cribriform carcinoma is a histologically and clinically distinctive type of tumour that should be separated from other similar tumour types. In this article, the pathology of cribriform adenocarcinoma of the prostate, lung, breast, stomach, colon, thyroid, and skin is discussed with particular reference to morphologic and immunohistochemical features, differential diagnosis, and clinical behaviour...
March 3, 2017: Oncology Reviews
https://www.readbyqxmd.com/read/28352187/risk-of-subsequent-primary-malignancies-among-patients-with-prior-colorectal-cancer-a-population-based-cohort-study
#5
Jiao Yang, Shuting Li, Meng Lv, Yinying Wu, Zheling Chen, Yanwei Shen, Biyuan Wang, Ling Chen, Min Yi, Jin Yang
BACKGROUND: The site-distribution pattern and relative risk of subsequent primary malignancies (SPMs) in colorectal cancer (CRC) patients remains to be determined. MATERIALS AND METHODS: A population-based cohort of 288,390 CRC patients diagnosed between 1973 and 2012 from the Surveillance, Epidemiology, and End Results database was retrospectively reviewed. Standardized incidence ratios were calculated to estimate the relative risk for SPMs. RESULTS: The overall risk of SPMs increased in CRC patients (standardized incidence ratio 1...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28322405/gastrointestinal-absorption-antiproliferative-and-anti-inflammatory-effect-of-the-major-carotenoids-of-gardenia-jasminoides-ellis-on-cancer-cells
#6
Hélder Oliveira, Xiaoshuang Cai, Qian Zhang, Victor de Freitas, Nuno Mateus, Jingren He, Iva Fernandes
The gastrointestinal absorption of the main carotenoids present in Gardenia jasminoides Ellis, crocetin, crocin-1 and crocin-2, was assayed through transport studies on MKN-28 and Caco-2 cell lines. Overall, crocetin was the compound that presented the highest gastrointestinal transport efficiency. Additionally, and since after absorption crocins are metabolized into crocetin, the antiproliferative capacity of crocetin was assayed in MKN-28 (stomach), MCF-7 (breast) and Caco-2 (colon) cancer cell lines. The results point to an antiproliferative effect of crocetin on the three cell lines tested...
April 19, 2017: Food & Function
https://www.readbyqxmd.com/read/28316229/mucinous-carcinoma-with-extensive-signet-ring-cell-differentiation-a-case-report
#7
Hye Min Kim, Eun Kyung Kim, Ja Seung Koo
Breast cancers that present with mucin include mucinous carcinoma and carcinoma with signet ring cell differentiation. The former shows extracellular mucin and the latter shows abundant intracellular mucin. Here, we report a case of breast cancer showing both extracellular mucin and extensive signet ring cell differentiation due to abundant intracellular mucin. Unlike mucinous carcinoma, this case had the features of high-grade nuclear pleomorphism, high mitotic index, estrogen receptor negativity, progesterone receptor negativity, human epidermal growth factor receptor-2 positivity, and ductal type with positivity for E-cadherin...
March 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28302993/content-analysis-of-news-coverage-on-cancer-prevention-and-screening-in-japanese-newspapers
#8
Rina Miyawaki, Kaori Ishii, Ai Shibata, Koichiro Oka
Objectives The present study investigated articles on cancer prevention published in Japanese newspapers in 2011.Methods A content analysis of news coverage on cancer primary prevention and screening was conducted. Articles which mentioned cancer risk, prevention, and screening were extracted. For all articles on prevention, the newspaper's name, month of publication, and information source were checked. Coding variables for articles on primary prevention included causes of human cancer, risk and/or prevention, and recommended screening criteria...
2017: [Nihon Kōshū Eisei Zasshi] Japanese Journal of Public Health
https://www.readbyqxmd.com/read/28297325/an-evaluation-of-organ-dose-modulation-on-a-ge-optima-ct660-computed-tomography-scanner
#9
Matthew T Dixon, Robert J Loader, Gregory C Stevens, Nick P Rowles
Organ Dose Modulation or ODM (GE Healthcare, Milwaukee, WI) was evaluated to characterize changes in CTDIvol, image noise, effective dose, and organ dose saving to patients. Three separate investigations were completed: a tube current modulation phantom was scanned with and without ODM, a CTDIvol phantom was scanned with ODM, and Monte Carlo simulations were performed. ODM was found to reduce the CTDIvol by approximately 20% whilst increasing the noise by approximately 14%. This was reflected in the dose distribution, where the anterior peripheral dose was reduced by approximately 40% whilst the identical posterior dose remained largely unaffected...
May 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28289662/mucosa-associated-lymphoid-tissue-lymphoma-of-the-cecum-and-rectum-a-case-report
#10
Myung Jin Nam, Byung Chang Kim, Sung Chan Park, Chang Won Hong, Kyung Su Han, Dae Kyung Sohn, Weon Seo Park, Hee Jin Chang, Jae Hwan Oh
A colonic mucosa-associated lymphoid-tissue (MALT) lymphoma is relatively rare compared to lymphomas of the stomach or small intestine. We present a case of a MALT lymphoma in the cecum and rectum found during screening colonoscopy. A 54-year-old female, who had undergone right-breast-conserving surgery with axillary dissection due to an invasive ductal carcinoma and a left-breast excisional biopsy due to microcalcification following adjuvant chemoradiation therapy 3 years earlier, was found to have 3-mm-sized smooth elevated lesions in both the cecum and rectum...
February 2017: Annals of Coloproctology
https://www.readbyqxmd.com/read/28279589/difference-of-stage-at-cancer-diagnosis-by-socioeconomic-status-for-four-target-cancers-of-the-national-cancer-screening-program-in-korea-results-from-the-gwangju-and-jeonnam-cancer-registries
#11
Sun-Seog Kweon, Min-Gyeong Kim, Mi-Ran Kang, Min-Ho Shin, Jin-Su Choi
BACKGROUND: The aim of this study was to evaluate whether stage at cancer diagnosis differed according to patient economic status. METHODS: A total of 10,528 patients with cancer of the stomach, colorectum, breast, or cervix, which are target organs of the Korean National Cancer Screening Program (NCSP; fully implemented in 2005) were extracted from population-based cancer registries. The patients were classified into four groups based on socioeconomic status (SES), as determined using their National Health Insurance (NHI) monthly premium at the time of cancer diagnosis...
March 6, 2017: Journal of Epidemiology
https://www.readbyqxmd.com/read/28265721/association-between-type-2-diabetes-and-risk-of-cancer-mortality-a-pooled-analysis-of-over-771-000-individuals-in-the-asia-cohort-consortium
#12
Yu Chen, Fen Wu, Eiko Saito, Yingsong Lin, Minkyo Song, Hung N Luu, Prakash C Gupta, Norie Sawada, Akiko Tamakoshi, Xiao-Ou Shu, Woon-Puay Koh, Yong-Bing Xiang, Yasutake Tomata, Kemmyo Sugiyama, Sue K Park, Keitaro Matsuo, Chisato Nagata, Yumi Sugawara, You-Lin Qiao, San-Lin You, Renwei Wang, Myung-Hee Shin, Wen-Harn Pan, Mangesh S Pednekar, Shoichiro Tsugane, Hui Cai, Jian-Min Yuan, Yu-Tang Gao, Ichiro Tsuji, Seiki Kanemura, Hidemi Ito, Keiko Wada, Yoon-Ok Ahn, Keun-Young Yoo, Habibul Ahsan, Kee Seng Chia, Paolo Boffetta, Wei Zheng, Manami Inoue, Daehee Kang, John D Potter
AIMS/HYPOTHESIS: The aims of the study were to evaluate the association between type 2 diabetes and the risk of death from any cancer and specific cancers in East and South Asians. METHODS: Pooled analyses were conducted of 19 prospective population-based cohorts included in the Asia Cohort Consortium, comprising data from 658,611 East Asians and 112,686 South Asians. HRs were used to compare individuals with diabetes at baseline with those without diabetes for the risk of death from any cancer and from site-specific cancers, including cancers of the oesophagus, stomach, colorectum, colon, rectum, liver, bile duct, pancreas, lung, breast, endometrium, cervix, ovary, prostate, bladder, kidney and thyroid, as well as lymphoma and leukaemia...
March 7, 2017: Diabetologia
https://www.readbyqxmd.com/read/28231672/-analysis-on-cancer-deaths-and-cause-eliminated-life-expectancy-among-residents-of-tianjin-2015
#13
Z L Xu, H Zhang, D Z Wang, G D Song, C F Shen, S Zhang, Y Zhang, G H Jiang
Objective: To explore the causes of cancer deaths and cause-eliminated-life-expectancy among residents of Tianjin. Methods: Data from the death registry system of Tianjin residents in 2015 were collected and cancers were grouped according to the classification of Global Burden of Disease. Specific cancer crude death rate and cause eliminated life expectancy (CELE) were calculated. Results: In 2015, 17 641 Tianjin residents died of cancer, with the crude death rate as 171.79 per 100 thousand and the standardized rate according to the Chinese population in 2000 as 86...
February 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28228842/worldwide-malaria-incidence-and-cancer-mortality-are-inversely-associated
#14
Li Qin, Changzhong Chen, Lili Chen, Ran Xue, Ming Ou-Yang, Chengzhi Zhou, Siting Zhao, Zhengxiang He, Yu Xia, Jianxing He, Pinghua Liu, Nanshan Zhong, Xiaoping Chen
BACKGROUND: Investigations on the effects of malaria infection on cancer mortality are limited except for the incidence of Burkitt's lymphoma (BL) in African children. Our previous murine lung cancer model study demonstrated that malaria infection significantly inhibited tumor growth and prolonged the life span of tumor-bearing mice. This study aims to assess the possible associations between malaria incidence and human cancer mortality. METHODS: We compiled data on worldwide malaria incidence and age-standardized mortality related to 30 types of cancer in 56 countries for the period 1955-2008, and analyzed their longitudinal correlations by a generalized additive mixed model (GAMM), adjusted for a nonlinear year effect and potential confounders such as country's income levels, life expectancies and geographical locations...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28212584/hyaluronic-acid-serum-albumin-conjugate-based-nanoparticles-for-targeted-cancer-therapy
#15
Ravit Edelman, Yehuda G Assaraf, Inna Levitzky, Tal Shahar, Yoav D Livney
Multiple carcinomas including breast, ovarian, colon, lung and stomach cancer, overexpress the hyaluronic acid (HA) receptor, CD44. Overexpression of CD44 contributes to key cancer processes including tumor invasion, metastasis, recurrence, and chemoresistance. Herein, we devised novel targeted nanoparticles (NPs) for delivery of anticancer chemotherapeutics, comprised of self-assembling Maillard reaction-based conjugates of HA and bovine serum albumin (BSA). HA served as the hydrophilic block, and as the ligand for actively targeting cancer cells overexpressing CD44...
April 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28195060/pathophysiology-and-clinical-characteristics-of-pain-in-most-common-locations-in-cancer-patients
#16
W Leppert, R Zajaczkowska, J Wordliczek, J Dobrogowski, J Woron, M Krzakowski
Pain is one of the most common symptoms in cancer patients, especially in advanced disease. However, pain also accompanies a significant percentage of patients during diagnostic and therapeutic procedures. In some patients pain may be the first symptom of the disease. The causes of pain in cancer patients are often multifactorial including direct and indirect cancer effects, anticancer therapy and co-morbidities. Moreover, pain in cancer patients often has mixed pathophysiology including both nociceptive and neuropathic components, especially in patients with bone metastases...
December 2016: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/28178396/immunological-evaluation-of-peptide-vaccination-for-cancer-patients-with-the-hla-a11-or-a33-allele
#17
Shinjiro Sakamoto, Satoko Matsueda, Shinzo Takamori, Uhi Toh, Masanori Noguchi, Shigeru Yutani, Akira Yamada, Shigeki Shichijo, Teppei Yamada, Shigetaka Suekane, Kouichiro Kawano, Masayasu Naitou, Tetsuro Sasada, Noboru Hattori, Nobuoki Kohno, Kyogo Itoh
The HLA-A11 or -A33 allele is found in approximately 18% or 10% of the Asian population, respectively, but each of which is a minor allele worldwide, and therefore no clinical trials were previously conducted. To develop a therapeutic peptide vaccine for each of them, we investigated immunological responses of advanced cancer patients with the HLA-A11(+) /A11(+) (n = 18) or -A33(+) /A33(+) (n = 13) allele to personalized peptide vaccine (PPV) regimens. The primary sites of HLA-A11+/A11+ or -A33+/A33+ patients were the colon (n = 4 or 2), stomach (2 or 3), breast (3 or 2), lung and pancreas (2 or 2), and so on...
February 8, 2017: Cancer Science
https://www.readbyqxmd.com/read/28152885/creating-an-online-resource-providing-hospital-cancer-surgery-volumes-in-california
#18
Laurence C Baker, Jennifer Malin, Joseph Parker, Merry Holliday-Hanson, Niya Fong, Stephanie Teleki, Lance Lang, Maryann O'Sullivan
172 Background: Little evidence is available to help patients and providers, payers and policymakers find the highest-quality hospitals for cancer surgery. We initiated a groundbreaking effort in California ( www.calqualitycare.org ) to publicly report hospital cancer surgery volume data online. METHODS: With financial support from the nonprofit California HealthCare Foundation, we assembled a multidisciplinary team to oversee the project and ensure sound methodology. We obtained existing hospital discharge summary data from the California Office of Statewide Health Planning and Development (OSHPD)...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28150875/atp2a3-gene-as-an-important-player-for-resveratrol-anticancer-activity-in-breast-cancer-cells
#19
Eduardo Izquierdo-Torres, Gabriela Rodríguez, Iván Meneses-Morales, Angel Zarain-Herzberg
The Ca(2+) -ATPases from the Sarco/endoplasmic reticulum (SERCA) are fundamental for maintaining intracellular [Ca(2+) ] homeostasis by pumping Ca(2+) into the endoplasmic reticulum (ER) of eukaryotic cells. SERCA enzymes are encoded by three different genes (ATP2A1-3), whose expression occurs in a tissue and development stage-specific manner. It has been reported alterations in the expression of SERCA2 and SERCA3 pumps in different types of cancer: oral, lung, colon, stomach, central nervous system, thyroid, breast, and prostate...
February 2, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28123722/systematic-analysis-of-the-achaete-scute-complex-like-gene-signature-in-clinical-cancer-patients
#20
Chih-Yang Wang, Payam Shahi, John Ting Wei Huang, Nam Nhut Phan, Zhengda Sun, Yen-Chang Lin, Ming-Derg Lai, Zena Werb
The achaete-scute complex-like (ASCL) family, also referred to as 'achaete-scute complex homolog' or 'achaete-scute family basic helix-loop-helix transcription factor', is critical for proper development of the nervous system and deregulation of ASCL plays a key role in psychiatric and neurological disorders. The ASCL family consists of five members, namely ASCL1, ASCL2, ASCL3, ASCL4 and ASCL5. The ASCL1 gene serves as a potential oncogene during lung cancer development. There is a correlation between increased ASCL2 expression and colon cancer development...
January 2017: Molecular and Clinical Oncology
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