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Immunonutrition AND Surgery

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https://www.readbyqxmd.com/read/29623417/peri-operative-oral-immunonutrition-in-malnourished-ovarian-cancer-patients-assessed-by-the-nutritional-risk-screening
#1
Linda Hertlein, Christine Zeder-Göß, Sophie Fürst, Daniela Bayer, Fabian Trillsch, Bastian Czogalla, Sven Mahner, Alexander Burges, Peter Rittler
OBJECTIVES: Aim of this study was to determine whether peri-operative immunonutrition can decrease complications and the length of stay (LOS) in malnourished ovarian cancer patients. STUDY DESIGN: Patients suspicious for advanced ovarian cancer before histopathological diagnosis and a nutritional risk score (NRS) ≥ 3 received oral immune-modulating diets (IMDs) for 5 days pre-operative and at least 5 days post-operative. Parameters for clinical outcome were infectious and non-infectious complications during hospital stay, and time of hospitalization...
April 5, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29596212/perioperative-nutritional-optimization-in-spine-surgery
#2
Rabia Qureshi, Mohammad Rasool, Varun Puvanesarajah, Hamid Hassanzadeh
Nutritional optimization in patients undergoing spine surgery is important as improved surgical outcomes and decreased rates of complications have been noted in optimized patients. With the increasingly high numbers of elderly patient and patients with metabolic comorbidities undergoing spine procedures, perioperative nutritional status should be enhanced for the best possible surgical outcomes. Methods of optimization include preoperative screening with Nutritional Risk Score or other scoring systems, looking for changes in body mass index, detecting sarcopenia, and screening for metabolic abnormalities...
April 2018: Clinical Spine Surgery
https://www.readbyqxmd.com/read/29594107/effects-of-enteral-immunonutrition-in-esophageal-cancer
#3
REVIEW
Kenji Mimatsu, Nobutada Fukino, Yasuo Ogasawara, Yoko Saino, Takatsugu Oida
Background: Immunonutrition (IN) significantly reduces the incidence of postoperative infectious complications and the length of hospitalization in patients undergoing major elective surgery for gastrointestinal malignances. However, the clinical benefit of IN in patients who have undergone esophagectomy for esophageal cancer is unclear. Moreover, the effect of enteral IN in patients during preoperative adjuvant chemoradiotherapy and in patients treated with concurrent chemoradiotherapy for advanced esophageal cancer is unknown...
February 2018: Gastrointestinal Tumors
https://www.readbyqxmd.com/read/29518432/perioperative-immunonutrition-modulates-inflammatory-response-after-radical-cystectomy-results-of-a-pilot-randomized-controlled-clinical-trial
#4
Jill M Hamilton-Reeves, Abigail Stanley, Misty D Bechtel, Thomas M Yankee, Prabhakar Chalise, Lauren K Hand, Eugene K Lee, Woodson Smelser, Moben Mirza, Hadley Wyre, Holly Hull, Susan E Carlson, Jeffrey M Holzbeierlein
PURPOSE: Poor preoperative nutritional status is associated with higher complication rates in bladder cancer patients after radical cystectomy (RC). Given the short lag time between diagnosis and RC, we compared a short-term Specialized IMmunonutrition (SIM) to a standard oral nutrition supplement (ONS) on the acute inflammatory response and arginine status in RC patients. MATERIALS AND METHODS: Twenty-nine men received SIM (n = 14) or ONS (n = 15) to drink three cartons/day for five days before and five days after RC in a prospective, randomized study...
March 5, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29420749/prospective-randomized-investigation-implementing-immunonutritional-therapy-using-a-nutritional-supplement-with-a-high-blend-ratio-of-%C3%AF-3-fatty-acids-during-the-perioperative-period-for-head-and-neck-carcinomas
#5
Nobuhiro Hanai, Hoshino Terada, Hitoshi Hirakawa, Hidenori Suzuki, Daisuke Nishikawa, Shintaro Beppu, Yasuhisa Hasegawa
Objectives: The purpose of this study is to evaluate whether a nutritional supplement with a high blend ratio of ω-3 fatty acids can minimize weight loss and attenuate increases in inflammatory marker levels during the perioperative period in patients undergoing surgery for head and neck carcinoma. Methods: Patients with ≥5% weight loss within 6 months were considered as targets for aggressive nutritional intervention. Among these patients, those with head and neck squamous cell carcinoma, who underwent major invasive surgery with free flap reconstruction were included in the present study...
February 6, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29368455/effect-of-preoperative-immunonutrition-on-postoperative-short-term-outcomes-of-patients-with-head-and-neck-squamous-cell-carcinoma
#6
Carla Aeberhard, Catherine Mayer, Simone Meyer, Simon Andreas Mueller, Philipp Schuetz, Zeno Stanga, Roland Giger
BACKGROUND: Patients with head and neck squamous cell carcinoma (HNSCC) often acquire an impaired nutritional status resulting in compromised outcomes. Perioperative immunonutrition may have a positive effect on outcomes after elective surgery. METHODS: Short-term outcomes before and after implementation of preoperative immunonutrition were retrospectively assessed. Regression models adjusted for outcome predictors were used to compare the length of stay (LOS) in the hospital, local infections, and general complications...
January 24, 2018: Head & Neck
https://www.readbyqxmd.com/read/29338698/enteral-immunonutrition-versus-enteral-nutrition-for-gastric-cancer-patients-undergoing-a-total-gastrectomy-a-systematic-review-and-meta-analysis
#7
Ying Cheng, Junfeng Zhang, Liwei Zhang, Juan Wu, Zhen Zhan
BACKGROUND: Nutrition support is a common means for patients with gastric cancer, especially for those undergoing elective surgery. Recently, enteral immunonutrition (EIN) was increasingly found to be more effective than enteral nutrition (EN) in enhancing the host immunity and eventually improving the prognosis of gastric cancer patients undergoing gastrectomy. However, the results reported were not consistent. This meta-analysis aimed to assess the impact of EIN for patients with GC on biochemical, immune indices and clinical outcomes...
January 16, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29335838/effect-of-immunonutrition-on-colorectal-cancer-patients-undergoing-surgery-a-meta-analysis
#8
Jing Xu, Xian Sun, Qianqian Xin, Ying Cheng, Zhen Zhan, Junfeng Zhang, Juan Wu
PURPOSE: Immunonutrition has been used to prevent the complications after colorectal elective surgery. This systematic review aimed to analyze and assess the effect of immunonutrition on colorectal cancer patients who received elective surgery. METHODS: Three electronic databases (Medline, Embase, Cochrane) were used to search the latent studies which investigated the effects of enteral immunonutrition (EIN) compared with standard enteral nutrition (EN) or parenteral immunonutrition (PIN) compared with standard parenteral nutrition (PN) on colorectal cancer patients who are undergoing surgery until 21st of April, 2017...
March 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29238571/immunonutrition-within-enhanced-recovery-after-surgery-eras-an-unresolved-matter
#9
EDITORIAL
Ruchir Gupta, Anthony Senagore
Preoperative malnutrition because of poor oral intake significantly increases the risk of adverse events after surgery and leads to increased length of stay. While immunonutrition has been utilized in the non-ERAS setting, its utility in both minimally invasive surgery and ERAS pathway procedures remain poorly defined. There are at least ten meta-analyses regarding the assessment of immunonutrition, but virtually, all of these were performed in an era prior to minimally invasive surgery, adoption of enhanced recovery protocols, and an understanding of the assessment and physiology of sarcopenia...
2017: Perioperative Medicine
https://www.readbyqxmd.com/read/29181067/preoperative-immunonutrition-regulates-tumor-infiltrative-lymphocytes-and-increases-tumor-angiogenesis-in-gastric-cancer-patients
#10
Kivanc Derya Peker, Sidika Seyma Ozkanli, Cebrail Akyuz, Orhan Uzun, Necdet Fatih Yasar, Mustafa Duman, Sinan Yol
Introduction: An increased number of tumor infiltrative lymphocytes (TILs) is considered a favorable prognostic factor in various cancers because it is a marker of antitumoral activity of the immune system. In this prospective, non-randomized clinical trial, we evaluated the impact of preoperative immunonutrition on tumor infiltrative lymphocytes and neoangiogenesis in cancerous tissue in patients with locoregional and resectable gastric adenocarcinoma. Material and methods: Patients with locoregional and resectable gastric adenocarcinoma were divided non-randomly into two study groups...
October 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29169443/perioperative-preparation-and-nutritional-considerations-for-patients-undergoing-urinary-diversion
#11
REVIEW
Jessie R Gills, Jeffrey M Holzbeierlein
Patients undergoing urinary diversion are at high risk for complications in the perioperative period. The exact cause of these complications remains poorly defined but is likely multifactorial. Current efforts to optimize patients in the perioperative period, including prehabilitation, smoking cessation, recognition and treatment of comorbid conditions and malnutrition, immunonutrition supplementation, carbohydrate loading, and prevention of known complications and implementation of enhanced recovery after surgery pathways, seem beneficial in helping to improve outcomes in this at-risk population...
February 2018: Urologic Clinics of North America
https://www.readbyqxmd.com/read/29130226/-prevention-and-treatment-of-perioperative-non-surgery-related-complications-in-elderly-patients-with-gastric-cancer
#12
Sheng Lu, Min Yan
The incidence of elderly gastric cancer patients is increasing, since the average life span is longer than ever before and the medical management is improved. Elderly patients usually have more comorbidities due to gradual loss of immunonutritional and functional status, leading to a higher rate of non-surgery-related postoperative morbidity and mortality. Along with the development of surgical and nursing technique, more and more surgeons would perform surgical procedures on elderly gastric cancer patients without hesitation...
October 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29022493/immunonutrition-before-esophagectomy-impact-on-immune-surveillance-mechanisms
#13
Marco Scarpa, Andromachi Kotsafti, Matteo Fassan, Melania Scarpa, Francesco Cavallin, Teresa Nardi, Eleonora Pinto, Rita Alfieri, Matteo Cagol, Marco Agostini, Massimo Rugge, Ignazio Castagliuolo, Carlo Castoro
Preoperative oral immunonutrition was demonstrated to improve immune response and to decrease the infection rate in patients with cancer. This study aimed to assess how immunonutrition could influence the immune cell response in the mucosal microenvironment of esophageal adenocarcinoma. Therefore, A prospective cohort of consecutive patients undergoing esophagectomy for esophageal adenocarcinoma was enrolled. A subgroup of them was given preoperative oral immunonutrition with Oral Impact® and was compared to those who received no preoperative supplementation...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28968919/nutritional-aspects-of-enhanced-recovery-after-esophagectomy-with-gastric-conduit-reconstruction
#14
REVIEW
B Feike Kingma, Elles Steenhagen, Jelle P Ruurda, Richard van Hillegersberg
Enhanced Recovery After Surgery (ERAS) aims to accelerate recovery by a set of multimodality management strategies. For esophagectomy, several nutritional elements of ERAS can be safely introduced and are advised in routine practice, including preadmission counseling to screen and treat for potential malnutrition, shortened preoperative fasting, and carbohydrate loading. However, the timing of oral intake and the use of routine nasogastric decompression remain matter of debate after esophagectomy. Furthermore, more research is needed on future developments such as perioperative immunonutrition...
October 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28944324/surgeons-approach-toward-clinical-nutrition-a-survey-based-study
#15
Bahadır Osman Bozkırlı, Rıza Haldun Gündoğdu, Soner Akbaba, Turgay Sayın, Pamir Eren Ersoy
OBJECTIVE: Although many surgical patients face postoperative problems due to a poor nutritional status, there is evidence that many cases of malnutrition still go unnoticed and untreated in surgical wards. This study aims to define the current attitudes of surgeons toward nutritional screening and support. MATERIAL AND METHODS: A questionnaire with 13 questions was e-mailed to 1500 surgeons. Cross-queries were made over the responses. RESULTS: The response rate was 20...
2017: Turkish journal of surgery
https://www.readbyqxmd.com/read/28940219/meta-analysis-of-immunonutrition-in-major-abdominal-surgery
#16
REVIEW
P Probst, S Ohmann, U Klaiber, F J Hüttner, A T Billeter, A Ulrich, M W Büchler, M K Diener
BACKGROUND: The objective of this study was to evaluate the potential benefits of immunonutrition in major abdominal surgery with special regard to subgroups and influence of bias. METHODS: A systematic literature search from January 1985 to July 2015 was performed in MEDLINE, Embase and CENTRAL. Only RCTs investigating immunonutrition in major abdominal surgery were included. Outcomes evaluated were mortality, overall complications, infectious complications and length of hospital stay...
November 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28734748/effects-of-arginine-based-immunonutrition-on-inpatient-total-costs-and-hospitalization-outcomes-for-patients-undergoing-colorectal-surgery
#17
Souvik Banerjee, Louis P Garrison, Aurelie Danel, Juan B Ochoa Gautier, David R Flum
OBJECTIVE: The aim of this study was to assess the effects of an arginine-based immunonutrition intervention for patients undergoing elective colorectal surgery on postsurgical utilization and cost outcomes. METHODS: This analysis was based on data from two Washington State databases: Surgical Care and Outcomes Assessment Program (SCOAP) linked to the Comprehensive Hospital Abstract Reporting System (CHARS). The sample (N=722) comprises adult patients who underwent elective colorectal surgery with anastomosis in a Washington State hospital that participated in the Strong for Surgery (S4S) initiative between January 1, 2012, and December 31, 2013...
June 24, 2017: Nutrition
https://www.readbyqxmd.com/read/28616919/-effects-of-early-enteral-immunonutrition-on-postoperative-immune-function-and-rehabilitation-of-patients-with-gastric-cancer-and-nutritional-risk
#18
Chang-Bing Peng, Wen-Zhong Li, Rui Xu, Wen Zhuang
OBJECTIVES: To investigate the effects of early enteral immunonutrition on postoperative immune function and rehabilitation of gastric cancer patients with nutritional risk. METHODS: New hospitalized patients with gastric cancer were evaluated the nutrient status based on NRS 2002. The patients who scored between 3 to 5 points were randomized into two groups(30 cases for each group), and those in experimental group were given 7-d early postoperative enteral immune nutrition, those in control group were given normal nutrition...
May 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28286066/emerging-impact-of-malnutrition-on-surgical-patients-literature-review-and-potential-implications-for-cystectomy-in-bladder-cancer
#19
REVIEW
Conrad M Tobert, Jill M Hamilton-Reeves, Lyse A Norian, Chermaine Hung, Nathan A Brooks, Jeff M Holzbeierlein, Tracy M Downs, Douglas P Robertson, Ruth Grossman, Kenneth G Nepple
PURPOSE: Malnutrition is emerging as a significant factor in patient outcomes. A contemporary review of malnutrition has not been performed for the urologist. We review the available literature and current standards of care for malnutrition screening, assessment and intervention, focusing on patients with bladder cancer treated with cystectomy. MATERIALS AND METHODS: Our multidisciplinary team searched PubMed® for available literature on malnutrition, focusing on definition and significance, importance to urologists, screening, assessment, diagnosis, immunological and economic impacts, and interventions...
September 2017: Journal of Urology
https://www.readbyqxmd.com/read/28162818/efficacy-of-preoperative-immunonutrition-in-locally-advanced-pancreatic-cancer-undergoing-irreversible-electroporation-ire
#20
RANDOMIZED CONTROLLED TRIAL
R C G Martin, S Agle, M Schlegel, T Hayat, C R Scoggins, K M McMasters, P Philips
BACKGROUND: Improved preoperative immunonutrition has been shown to decrease the length of stay (LOS) and complications among patients undergoing elective gastrointestinal cancer surgeries. The purpose of this study was to determine whether preoperative immunonutrition supplementation decreases postoperative LOS, infectious complications, and morbidity in patients undergoing irreversible electroporation (IRE) surgery for locally advanced pancreatic cancer (LAPC). METHODS: At a regional hepatopancreatobiliary referral center within an academic medical center 71 patients receiving IRE treatment of LAPC were included in the study...
April 2017: European Journal of Surgical Oncology
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