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https://www.readbyqxmd.com/read/11850571/molecular-detection-of-minimal-residual-disease-for-patients-with-leukaemia-and-lymphoma
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R Liang, D Chan, Y L Kwong, V Chan
Although a complete clinical remission can often be achieved with chemotherapy for patients with leukaemia and lymphoma, relapses still occur. Residual tumour cells probably have survived therapy and account for subsequent disease relapse. The sensitivity of conventioned ways of detecting residual tumour cells, such as morphological studies, immunophenotyping, and cytogenetics, is only about 1% to 5% and may be inadequate. Polymerase chain reaction technology has provided a simple and highly sensitive means for the detection of minimal residual disease...
June 1997: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
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