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Down syndrome AND swimming

Ning Yang, Dan-Feng Zhang, Zhen Tao, Meng Li, Su-Ming Zhou, Guo-Liang Wang
Class B scavenger receptors (SRBs), which are present in mammals and insects, have been implicated in a wide range of functions. Herein, a novel SRB homologue, PtSRB, was cloned from the swimming crab, Portunus trituberculatus. PtSRB has 538 amino acid residues, and it consists of two transmembrane regions, a large extracellular loop, and two intracellular tails. A phylogenetic analysis showed that PtSRB distinctly clustered with Marsupenaeus japonicas SRB-1 and most Drosophila SRB homologues, including Croquemort, Peste, NinaD, and Santa Maria, but was separate from the Drosophila sensory neuron membrane protein, MjSRB-2, and all vertebrate SRBs...
September 12, 2016: Fish & Shellfish Immunology
Qiuxiao Yu, Shuxian Hao, Huamin Wang, Xi Song, Qiyang Shen, Jihong Kang
Patients with polycystic ovary syndrome (PCOS) can suffer from psychological disorders, among which depression is the most commonly diagnosed. However, the pathogenesis is still unclear. The aims of the present study were to investigate the behaviors of dehydroepiandrosterone (DHEA)-induced PCOS mice, the effects of high-fat diet (HFD) on mouse behaviors, and the underlying mechanism. Prepubertal C57BL/6 mice (25 days of age) were divided into four groups and injected daily with the vehicle sesame oil or DHEA on the normal chow or a 60% HFD for 20 consecutive days...
October 2016: Biology of Reproduction
Torrey L S Truszkowski, Eric J James, Mashfiq Hasan, Tyler J Wishard, Zhenyu Liu, Kara G Pratt, Hollis T Cline, Carlos D Aizenman
BACKGROUND: Fragile X Syndrome is the leading monogenetic cause of autism and most common form of intellectual disability. Previous studies have implicated changes in dendritic spine architecture as the primary result of loss of Fragile X Mental Retardation Protein (FMRP), but recent work has shown that neural proliferation is decreased and cell death is increased with either loss of FMRP or overexpression of FMRP. The purpose of this study was to investigate the effects of loss of FMRP on behavior and cellular activity...
August 8, 2016: Neural Development
Ying-pan Zhao, Min Su, Feng-yun Wang, Zhao-xiang Bian, Jian-qin Yang, Wei Wang, Xu-dong Tang
OBJECTIVE: To explore the effect of Chang'an No. I Recipe (CA) on 5-hydroxytryptamine signal system and mRNA expression levels of hippocampal brain derived neurotrophic factor (BDNF) in visceral hypersensitivity model rats with irritable bowel syndrome (IBS). METHODS: IBS visceral hypersensitivity rat models were established by combined chronic restraint stress and forced swimming. Successfully modeled rats were randomly divided into the model group, the Dicetelgroup (27 mg/kg) , the Fluoxetine group (3...
October 2015: Chinese Journal of Integrated Traditional and Western Medicine
Jie Zhu, Baoqin Wang, Zegeng Li, Mei Lu, Qinghe Peng, Cheng Yang, Jiabing Tong
OBJECTIVE: To investigate the effect of Qibaipingfei Capsule (QPC) on the expressions of calcineurin (CaN) and nuclear factor of activated T-cells isoform c3 (NFATc3) of rat models with phlegm and blood stasis syndrome of chronic obstructive pulmonary disease (COPD), and to explore the possible mechanism underlying the intervention of QPC in pulmonary vascular remodeling of COPD. METHODS: Sixty male Sprague-Dawley (SD) rats were randomly divided into a normal group, a model group, a positive group of nifedipine, a high dose group, a middle dose group and a low dose group of QPC...
November 2015: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
Fei Liu, Wenjun Xia, Jiongjiong Hu, Yingzhi Wang, Fan Yang, Shaoyang Sun, Jin Zhang, Nan Jiang, Huijun Wang, Weidong Tian, Xu Wang, Duan Ma
Hearing loss is one of the most prevalent human birth defects. Genetic factors contribute to the pathogenesis of deafness. It is estimated that one-third of deafness genes have already been identified. The current work is an attempt to find novel genes relevant to hearing loss using guilt-by-profiling and guilt-by-association bioinformatics analyses of approximately 80 known non-syndromic hereditary hearing loss (NSHL) genes. Among the 300 newly identified candidate deafness genes, slc26a2 were selected for functional studies in zebrafish...
2015: PloS One
Su-Ming Zhou, Xue-Mei Yuan, Shun Liu, Meng Li, Zhen Tao, Guo-Liang Wang
The Toll signaling pathway is one of the most important regulators of the immune response in both vertebrates and invertebrates. Herein, three novel Toll (PtToll1-3) cDNA sequences were cloned from the swimming crab, Portunus trituberculatus. PtToll1 has 1003 amino acid residues and consists of an extracellular domain containing 15 leucine-rich repeats (LRRs) and a cytoplasmic Toll/interleukin-1 receptor (TIR) domain of 139 residues. PtToll2 encodes 1196 peptides, with an extracellular domain containing 28 LRRs and a cytoplasmic TIR domain...
October 2015: Fish & Shellfish Immunology
Libin Zhou, Jun Yin, Conghui Wang, Jiawei Liao, George Liu, Ling Chen
The Seipin gene was originally found to be responsible for type 2 congenital lipodystrophy and involved in lipid droplet formation. Seipin is highly expressed in the central nervous system as well. Seipin mutations have been identified in motor neuron diseases such as Silver syndrome and spastic paraplegia. In this study, we generated neuron-specific seipin knockout mice (seipin-nKO) to investigate the influence of seipin deficiency on locomotion and affective behaviors. In comparison with control mice, 8-week-old male seipin-nKO mice, but not female mice, displayed anxiety- and depression-like behaviors as assessed by open-field, elevated plus-maze, forced swim and tail suspension tests...
August 1, 2014: Human Molecular Genetics
Amanda Faith Casey, Marilyn Mackay-Lyons, Eilish Marie Connolly, Craig Jennings, Roy Rasmussen
PURPOSE: Individuals with Down syndrome (DS) may be at heightened risk for stroke due to a combination of physiological conditions and lifestyle choices. There remains a lack of information regarding the effectiveness of exercise training on individuals with DS post-stroke. This case report describes the effects of a comprehensive exercise program on an individual with DS who had sustained a stroke. METHOD: A 20-year-old male with DS recovering from a left hemorrhagic stroke 18 months previous underwent a 12-week land and water-based program 60 minutes/session, 5 sessions/week...
2014: Disability and Rehabilitation
H F Sakr
Western diet rich in cholesterol and sucrose with decreased physical activity cause overweight and metabolic syndrome. The aim of the present study was to investigate the effect of swimming on the cardiac adiponectin mRNA expression in high cholesterol and fructose fed rats. Forty Sprague-Dawley male rats divided into 2 equal groups. First group - control, that was fed with chow diet for 15 weeks. Second group was fed with high cholesterol and fructose diet (HCFD) for 15 weeks. Ten rats from both groups performed swimming during the last 4 weeks...
April 2013: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
Yeshayahu Hutzler, Mali Oz, Sharon Barak
Based on social-learning and self-determination motivational theories, the purpose of this study was to determine the sources of motivation in youth and young adults with intellectual disability (ID) who participate in Special Olympics (SO) competitions and those of typically developed (TD) age- and activity-matched athletes. A convenience sample of 63 SO (25 females and 38 males) and 59 TD (16 females and 43 males) athletes was retrieved through communication with local club coaches. Three sub-groups of SO athletes were identified based on disability, including non specified intellectual disability (NSID=39), Down syndrome (DS=17), and Autism (Aut=7)...
July 2013: Research in Developmental Disabilities
Inês Marques-Aleixo, Ana Querido, Pedro Figueiredo, João Paulo Vilas-Boas, Rui Corredeira, Daniel Daly, Ricardo J Fernandes
This study examined the differences in intracycle velocity variation and arm coordination in front crawl in swimmers with Down syndrome in three breathing conditions. International swimmers with Down syndrome (N = 16) performed 3 × 20 m front crawl at 50 m race speed: without breathing, breathing to the preferred side, and breathing to the nonpreferred side. A two dimensional video movement analysis was performed using the APASystem. Breathing conditions were compared using Repeated Measures ANOVA. Swimming velocity was higher without breathing and intracyclic velocity variation was higher while breathing...
January 2013: Adapted Physical Activity Quarterly: APAQ
Brandon H Cline, Harry W M Steinbusch, Dmitry Malin, Alexander V Revishchin, Galia V Pavlova, Raymond Cespuglio, Tatyana Strekalova
BACKGROUND: A number of epidemiological studies have established a link between insulin resistance and the prevalence of depression. The occurrence of depression was found to precede the onset of diabetes and was hypothesized to be associated with inherited inter-related insufficiency of the peripheral and central insulin receptors. Recently, dicholine succinate, a sensitizer of the neuronal insulin receptor, was shown to stimulate insulin-dependent H2O2 production of the mitochondrial respiratory chain leading to an enhancement of insulin receptor autophosphorylation in neurons...
2012: BMC Neuroscience
Chang-Zheng Liu, Bo Lei
OBJECTIVE: To study the effect of acupuncture on blood oxygen free radical metabolism in rats with chronic fatigue syndrome (CFS). METHODS: Thirty male SD rats were randomly divided into control group (n = 10), model group (n = 10) and acupuncture group (n = 10). CFS model was established by repeated suspension (1.0-2.5 h) and forced cold water swimming (7 min), once daily continuously for 12 days. For rats in the acupuncture group, bilateral "Zusanli" (ST 36) and "Sanyinjiao" (SP 6) were stimulated by manipulating the acupuncture needles intermittently for 20 min, once daily, and with 7 days being a treatment course...
February 2012: Zhen Ci Yan Jiu, Acupuncture Research
P K Singh, K Chopra, A Kuhad, I P Kaur
BACKGROUND:   In recent years the interface between neuropsychiatry and gastroenterology has converged in to a new discipline referred to as enteric neuroscience. Implications of brain-gut communication in the pathogenesis of psychiatric disorders indicate a possible role of suitably packaged/delivered probiotics as newer therapeutic options. In the present study probable role of per-oral administration of free Lactobacillus acidophilus (LAB) and LAB loaded alginate beads in attenuation of the symptoms associated with chronic fatigue syndrome (CFS) were evaluated...
April 2012: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
Laura Capranica, Mindy L Millard-Stafford
A prevailing theory (and practical application) is that elite performance requires early childhood skill development and training across various domains, including sport. Debate continues whether children specializing early (ie, training/competition in a single sport) have true advantage compared with those who sample various sports early and specialize in a single sport later (adolescence). Retrospective data and case studies suggest either model yields elite status depending upon the sport category (ie, situational: ball games, martial arts, fencing; quantitative: track and field, swimming, skiing; or qualitative: gymnastics, diving, figure skating)...
December 2011: International Journal of Sports Physiology and Performance
Jessica Arseneault-Bréard, Isabelle Rondeau, Kim Gilbert, Stéphanie-Anne Girard, Thomas A Tompkins, Roger Godbout, Guy Rousseau
Myocardial infarction (MI) in rats is accompanied by apoptosis in the limbic system and a behavioural syndrome similar to models of depression. We have already shown that probiotics can reduce post-MI apoptosis and designed the present study to determine if probiotics can also prevent post-MI depressive behaviour. We also tested the hypothesis that probiotics achieve their central effects through changes in the intestinal barrier. MI was induced in anaesthetised rats via 40-min transient occlusion of the left anterior coronary artery...
June 2012: British Journal of Nutrition
Amanda Faith Casey, Claudia Emes
Reduced respiratory muscle strength in individuals with Down syndrome (DS) may affect speech respiratory variables such as maximum phonation duration (MPD), initiation volume, and expired mean airflow. Researchers randomly assigned adolescents with DS (N = 28) to either 12 weeks of swim training (DS-ST) or a control group (DS-NT). Repeated measures MANOVA demonstrated a significant increase in MPD for DS-ST participants from pretest to posttest, t(11) = -3.44, p = 0.006, that was not maintained at follow-up, t(11) = 6...
October 2011: Adapted Physical Activity Quarterly: APAQ
Elizabeth A Geelhoed, Ami Bebbington, Carol Bower, Aditya Deshpande, Helen Leonard
OBJECTIVE: To assess the direct annual health care costs for children and adolescents with Down syndrome in Western Australia and to explore the variation in health care use including respite, according to age and disease profile. STUDY DESIGN: Population-based data were derived from a cross-sectional questionnaire that was distributed to all families who had a child with Down syndrome as old as 25 years of age in Western Australia. RESULTS: Seventy-three percent of families (363/500) responded to the survey...
October 2011: Journal of Pediatrics
Shi-yi Song, Yan-jie Wang, De-shan Wang, Ji-yan Chai
OBJECTIVE: To investigate the effect of oculo-acupuncture therapy (OAT) on the alteration of colonic serotonin reuptake transporter (SERT) expression in rats with irritable bowel syndrome (IBS) so as to explore its underlying mechanism in relieving IBS. METHODS: Thirty male Wistar rats were randomized into control, IBS model and OAT groups (n = 10/group). IBS model was established by repeated stress stimulation [water-intake inhibition (24 h), warm box keeping (40 degrees C,5 min), electric shock stimulation (30 V, 120 s), forced cool water swimming (14 t, 5 min), 24 h fasting, and tail clamping (180 s)] for 18 days...
April 2011: Zhen Ci Yan Jiu, Acupuncture Research
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