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Down syndrome AND exercise

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https://www.readbyqxmd.com/read/29573317/oxygen-uptake-efficiency-slope-during-exercise-in-adults-with-down-syndrome
#1
Goncalo V Mendonca, Afonso Borges, Sang O Wee, Bo Fernhall
BACKGROUND: Persons with Down syndrome (DS) have low aerobic exercise capacity. The present authors sought to compare the oxygen uptake efficiency slope (OUES) between adults with and without DS performing graded exercise testing (GXT) and to investigate its relationship with peak oxygen uptake (VO2peak ) in both groups of participants. METHOD: Twenty-three participants with DS and 24 non-disabled controls performed GXT with VO2 measurements. OUES was calculated from data of the first 75%, 90% and 100% GXT time...
March 24, 2018: Journal of Applied Research in Intellectual Disabilities: JARID
https://www.readbyqxmd.com/read/29554987/impact-of-medication-on-protein-and-amino-acid-metabolism-in-the-elderly-the-sulfur-amino-acid-and-paracetamol-case
#2
Carole Mast, Dominique Dardevet, Isabelle Papet
The optimisation of nutritional support for the growing number of older individuals does not usually take into account medication. Paracetamol (acetaminophen; APAP) is the first intention treatment of chronic pain that is highly prevalent and persistent in the elderly. Detoxification of APAP occurs in the liver and utilises sulfate and glutathione (GSH), both of which are issued from cysteine (Cys), a conditionally indispensable amino acid. The detoxification-induced siphoning of Cys could reduce the availability of Cys for skeletal muscle...
March 20, 2018: Nutrition Research Reviews
https://www.readbyqxmd.com/read/29536504/respiratory-morbidity-in-rett-syndrome-an-observational-study
#3
Jessica MacKay, Helen Leonard, Kingsley Wong, Andrew Wilson, Jenny Downs
AIM: Respiratory illness is a major cause of morbidity and mortality in Rett syndrome. This study investigated respiratory morbidity and relationships with age, mutation type, feeding, and walking status. METHOD: Families registered with the InterRett database (n=399) provided data on the health of their child with Rett syndrome (age 2-57y). Hospital admissions because of lower respiratory tract infection (LRTI) over a 5-year exposure period were investigated by age, mutation type, enteral feeding, and walking status...
March 14, 2018: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29501470/changes-in-cognitive-function-after-a-12-week-exercise-intervention-in-adults-with-down-syndrome
#4
Lauren T Ptomey, Amanda N Szabo, Erik A Willis, Anna M Gorczyca, J Leon Greene, Jessica C Danon, Joseph E Donnelly
BACKGROUND: Between 250,000 and 400,000 individuals in the United States are diagnosed with Down syndrome (DS). Nearly all adults with DS will develop Alzheimer's disease pathology starting in their thirties. Recent studies suggest that increased physical activity (PA) may be important for maintaining components of cognition, including memory. OBJECTIVE: The purpose of this study was to evaluate changes in cognitive function after completion of a 12-week exercise intervention in adults with DS...
February 26, 2018: Disability and Health Journal
https://www.readbyqxmd.com/read/29484778/walking-performance-in-adolescents-and-young-adults-with-down-syndrome-the-role-of-obesity-and-sleep-problems
#5
C-C J J Chen, S D R Ringenbach
BACKGROUND: High prevalence of obesity and features of obstructive sleep apnea (OSA) are major health issues in individuals with Down syndrome (DS), and both may also affect adversely on their daily activities. Further, lower levels of physical work capacity (PWC) have been reported in this population compared to their peers with intellectual disabilities. However, no study examines the relationships between obesity and sleep problems with PWC in individuals with DS. Thus, this study investigated the influence of body mass index (BMI) and different types of sleep problems on PWC in adolescents and young adults with DS (14-31 years)...
February 27, 2018: Journal of Intellectual Disability Research: JIDR
https://www.readbyqxmd.com/read/29468933/endocrinology-and-pediatric-exercise-science-the-year-that-was-2017
#6
Alon Eliakim
The Pediatric Exercise Science "Year That Was" section aims to highlight the most important (to the author's opinion) manuscripts that were published in 2017 in the field of endocrinology and pediatric exercise science. This year's selection includes studies showing that 1) in pubertal swimmers, there is a decrease in insulin-like growth factor-1 (IGF-I) and IGF-binding protein-3 (IGFBP-3) during intense training (a catabolic-type hormonal response) with an anabolic "rebound" characterized by a significant increase of these growth factors during training tapering down...
February 22, 2018: Pediatric Exercise Science
https://www.readbyqxmd.com/read/29461969/toll-like-receptor-expression-induced-by-exercise-in-obesity-and-metabolic-syndrome-a-systematic-review
#7
Isabel Rada, Louise Deldicque, Marc Francaux, Hermann Zbinden-Foncea
BACKGROUND: Obesity and metabolic syndrome are disorders that correlate with the activation of pro-inflammatory pathways and cytokine production, to which Toll like receptors (TLR) contribute. Exercise may act as an anti-inflammatory modulator, but there is no consensus about the role of the TLR in this tuning. The present styudy aims to systematically review the current evidence on exercise-induced TLR regulation in animals and humans suffering from obesity and metabolic syndrome. METHODS: Pubmed and Scopus databases were searched for publications from 1990 to September 2015...
2018: Exercise Immunology Review
https://www.readbyqxmd.com/read/29343130/a-community-based-exercise-program-to-increase-participation-in-physical-activities-among-youth-with-disability-a-feasibility-study
#8
Nora Shields, Roos van den Bos, Kirsty Buhlert-Smith, Luke Prendergast, Nicholas Taylor
PURPOSE: To evaluate the feasibility of a student-mentored community-based exercise program for youth with disability. METHOD: Nineteen youth (nine female; mean age 18 years) with disability (seven cerebral palsy, six Down syndrome, three spina bifida, two autism spectrum disorder, one spinal cord injury) were recruited. Each participant was matched with a student mentor and exercised twice a week for 12 weeks at their local gymnasium. Five domains of feasibility were assessed: demand, implementation, practicality, limited efficacy testing, and acceptability...
January 17, 2018: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29330572/effects-of-whole-body-vibration-on-muscle-strength-bone-mineral-content-and-density-and-balance-and-body-composition-of-children-and-adolescents-with-down-syndrome-a-systematic-review
#9
REVIEW
M B Saquetto, F F Pereira, R S Queiroz, C M da Silva, C S Conceição, M Gomes Neto
The aim of this study is to verify the effects of whole-body vibration (WBV) training on the muscle strength of children and adolescents with Down syndrome. We searched MEDLINE, Cochrane, SciELO, Lilacs and PUBMED databases and included manual searches to identify randomised controlled trials to investigate the effects of WBV on the structure and body function of children and adolescents with Down syndrome. Two reviewers independently selected the studies and performed statistical analysis. In total, five studies with 171 patients that compared WBV with exercise and/or control were included...
March 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29321033/environmental-enrichment-intervention-for-rett-syndrome-an-individually-randomised-stepped-wedge-trial
#10
Jenny Downs, Jenny Rodger, Chen Li, Xuesong Tan, Nan Hu, Kingsley Wong, Nicholas de Klerk, Helen Leonard
BACKGROUND: Rett syndrome is caused by a pathogenic mutation in the MECP2 gene with major consequences for motor and cognitive development. One of the effects of impaired MECP2 function is reduced production of Brain Derived Neurotrophic Factor (BDNF), a protein required for normal neuronal development. When housed in an enriched environment, MECP2 null mice improved motor abilities and increased levels of BDNF in the brain. We investigated the effects of environmental enrichment on gross motor skills and blood BDNF levels in girls with Rett syndrome...
January 10, 2018: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/29231277/do-individuals-with-intellectual-disability-have-a-lower-peak-heart-rate-and-maximal-oxygen-uptake
#11
Thessa Irena Maria Hilgenkamp, Tracy Baynard
BACKGROUND: Individuals with intellectual disability (ID) have very low physical activity and low peak oxygen uptake (VO2peak ), potentially explained by physiologically lower peak heart rates (HRpeak ). METHOD: The present authors performed a retrospective analysis of a large data set of individuals with intellectual disability (n = 100), with Down syndrome (DS) (n = 48) and without intellectual disability (n = 224) using multiple linear regression analyses, to determine if individuals with intellectual disability exhibit lower HRpeak and VO2peak than individuals without intellectual disability, controlling for age, sex and body mass index (BMI)...
December 12, 2017: Journal of Applied Research in Intellectual Disabilities: JARID
https://www.readbyqxmd.com/read/29203796/aerobic-exercise-and-a-bdnf-mimetic-therapy-rescue-learning-and-memory-in-a-mouse-model-of-down-syndrome
#12
Martina Parrini, Diego Ghezzi, Gabriele Deidda, Lucian Medrihan, Enrico Castroflorio, Micol Alberti, Pietro Baldelli, Laura Cancedda, Andrea Contestabile
Down syndrome (DS) is caused by the triplication of human chromosome 21 and represents the most frequent genetic cause of intellectual disability. The trisomic Ts65Dn mouse model of DS shows synaptic deficits and reproduces the essential cognitive disabilities of the human syndrome. Aerobic exercise improved various neurophysiological dysfunctions in Ts65Dn mice, including hippocampal synaptic deficits, by promoting synaptogenesis and neurotransmission at glutamatergic terminals. Most importantly, the same intervention also prompted the recovery of hippocampal adult neurogenesis and synaptic plasticity and restored cognitive performance in trisomic mice...
December 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29192799/communication-as-a-human-right-citizenship-politics-and-the-role-of-the-speech-language-pathologist
#13
Declan Murphy, Rena Lyons, Clare Carroll, Mari Caulfield, Gráinne De Paor
According to Article 19 of the Universal Declaration on Human Rights "Everyone has the right to freedom of opinion and expression; this right includes freedom to hold opinions without interference and to seek, receive and impart information and ideas through any media and regardless of frontiers." The purpose of this paper is to elucidate communication as a human right in the life of a young man called Declan who has Down syndrome. This commentary paper is co-written by Declan, his sister who is a speech-language pathologist (SLP) with an advocacy role, his SLP, and academics...
February 2018: International Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/29103914/what-effect-does-regular-exercise-have-on-oxidative-stress-in-people-with-down-syndrome-a-systematic-review-with-meta-analyses
#14
REVIEW
Nora Shields, Jenny Downs, Judy B de Haan, Nicholas F Taylor, Jennifer Torr, Bo Fernhall, Michael Kingsley, George Mnatzaganian, Helen Leonard
OBJECTIVE: What effect does regular exercise have on oxidative stress in people with Down syndrome? DESIGN: Systematic review with meta-analyses. METHODS: A systematic review with meta-analyses was conducted. Six databases were searched from inception until August 2017. Studies where included if participants with Down syndrome (any age) had completed an exercise program of at least 6 weeks duration and at least one biomarker measured the generation or removal of reactive oxidative species...
October 19, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/29056568/anatomic-and-functional-outcomes-of-paramesonephric-remnant-supported-laparoscopic-double-layer-peritoneal-pull-down-vaginoplasty-technique-in-patients-with-mayer-rokitansky-k%C3%A3-ster-hauser-syndrome-uncu-modification
#15
Gürkan Uncu, Kemal Özerkan, Barış Ata, Işıl Kasapoğlu, Mehmet Aral Atalay, Adnan Orhan, Kiper Aslan
OBJECTIVE: To describe modifications to the double-layer peritoneal pull-down laparoscopic vaginoplasty technique (Davydov operation) and evaluate anatomic and functional outcomes of the new technique, known as the Uncu modification. DESIGN: Case series (Canadian Task Force classification III). SETTING: Tertiary care university hospital. PATIENTS: Women with Mayer-Rokitansky-Küster-Hauser syndrome (MRKHS) who underwent surgery between 2010 and 2016...
October 19, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28904967/foot-structure-in-boys-with-down-syndrome
#16
Ewa Puszczałowska-Lizis, Krzysztof Nowak, Jarosław Omorczyk, Tadeusz Ambroży, Przemysław Bujas, Leszek Nosiadek
INTRODUCTION AND AIM: Down syndrome (DS) is associated with numerous developmental abnormalities, some of which cause dysfunctions of the posture and the locomotor system. The analysis of selected features of the foot structure in boys with DS versus their peers without developmental disorders is done. MATERIALS AND METHODS: The podoscopic examination was performed on 30 boys with DS aged 14-15 years. A control group consisted of 30 age- and gender-matched peers without DS...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28676038/efficacy-and-safety-of-oral-sildenafil-in-children-with-down-syndrome-and-pulmonary-hypertension
#17
RANDOMIZED CONTROLLED TRIAL
Maurice Beghetti, Andrzej Rudzinski, Min Zhang
BACKGROUND: Despite the increased risk for pulmonary hypertension in children with Down syndrome, the response to treatment with targeted therapies for pulmonary hypertension in these patients is not well characterized. The Sildenafil in Treatment-naive children, Aged 1-17 years, with pulmonary arterial hypertension (STARTS-1) trial was a dose-ranging study of the short-term efficacy and safety of oral sildenafil in children with pulmonary arterial hypertension. We assessed the safety and efficacy of oral sildenafil in children with Down syndrome and pulmonary arterial hypertension...
July 4, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28586511/factors-affecting-dance-exercise-performance-in-students-at-a-special-needs-school
#18
Yukiko Ito, Izumi Hiramoto, Hideya Kodama
BACKGROUND: In Japan, dance exercise has been introduced as a compulsory element of health and physical education, but there is a considerable discrepancy in the levels of performance among students with intellectual disability (ID) at special needs schools. The aim of this study was therefore to identify the factors affecting the performance of dance exercise in students with ID. METHODS: A 4 month dance exercise program was implemented for junior high school students at a special needs school, and the performance of 32 students at 22 sessions was assessed quantitatively according to calorie use during exercise and performance proficiency score...
June 6, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28585394/wii-based-exercise-program-to-improve-physical-fitness-motor-proficiency-and-functional-mobility-in-adults-with-down-syndrome
#19
V Silva, C Campos, A Sá, M Cavadas, J Pinto, P Simões, S Machado, E Murillo-Rodríguez, N Barbosa-Rocha
BACKGROUND: People with Down syndrome (DS) usually display reduced physical fitness (aerobic capacity, muscle strength and abnormal body composition), motor proficiency impairments (balance and postural control) and physical functional limitations. Exergames can be an appealing alternative to enhance exercise engagement and compliance, whilst improving physical fitness and motor function. This study aims to analyse the effects of a Wii-based exercise program on physical fitness, functional mobility and motor proficiency of adults with DS...
August 2017: Journal of Intellectual Disability Research: JIDR
https://www.readbyqxmd.com/read/28535762/gait-initiation-and-termination-strategies-in-patients-with-prader-willi-syndrome
#20
Veronica Cimolin, Nicola Cau, Manuela Galli, Cristina Santovito, Graziano Grugni, Paolo Capodaglio
BACKGROUND: Gait Initiation (GI) is a functional task representing one of the first voluntary destabilizing behaviours observed in the development of a locomotor pattern as the whole body centre of mass transitions from a large to a small base of support. Conversely, Gait Termination (GT) consists in the transition from walking to standing which, in everyday life, is a very common movement. Compared to normal walking, it requires higher control of postural stability. For a safe GT, the forward movement of the body has to be slowed down to achieve a stable upright position...
May 23, 2017: Journal of Neuroengineering and Rehabilitation
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