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https://www.readbyqxmd.com/read/28235249/secukinumab-sustains-improvement-in-signs-and-symptoms-of-patients-with-active-ankylosing-spondylitis-through-2-years-results-from-a-phase-3-study
#1
H Marzo-Ortega, J Sieper, A Kivitz, R Blanco, M Cohen, R Martin, A Readie, H B Richards, B Porter
OBJECTIVE: Secukinumab improved the signs and symptoms of ankylosing spondylitis (AS) over 52 weeks in the phase 3 MEASURE 2 study (NCT01649375). Here, we report longer-term (104 weeks) efficacy and safety results. METHODS: Patients with active AS were randomized to subcutaneous secukinumab 150 mg, 75 mg, or placebo at baseline; weeks 1, 2 and 3; and every 4 weeks from week 4. The primary endpoint was the ASAS20 response rate at week 16. Other endpoints included ASAS40, hsCRP, ASAS5/6, BASDAI, SF-36 PCS, ASAS partial remission, EQ-5D, and FACIT-Fatigue...
February 24, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28235077/luxcde-luxab-based-promoter-reporter-system-to-monitor-the-yersinia-enterocolitica-o-3-gene-expression-in-vivo
#2
Elif Bozcal, Melih Dagdeviren, Atac Uzel, Mikael Skurnik
It is crucial to understand the in vitro and in vivo regulation of the virulence factor genes of bacterial pathogens. In this study, we describe the construction of a versatile reporter system for Yersinia enterocolitica serotype O:3 (YeO3) based on the luxCDABE operon. In strain YeO3-luxCDE we integrated the luciferase substrate biosynthetic genes, luxCDE, into the genome of the bacterium so that the substrate is constitutively produced. The luxAB genes that encode the luciferase enzyme were cloned into a suicide vector to allow cloning of any promoter-containing fragment upstream the genes...
2017: PloS One
https://www.readbyqxmd.com/read/28233360/emergency-department-and-inpatient-coding-for-self-harm-and-suicide-attempts-validation-using-clinician-assessment-data
#3
Jason R Randall, Leslie L Roos, Lisa M Lix, Laurence Y Katz, James M Bolton
Administrative data have been used to determine the occurrence of suicide attempts and deliberate self-harm, but research about the accuracy of these sources is limited. This study used a clinical sample (n = 5719) containing psychiatry consultations from the emergency departments and inpatient units of the two major tertiary hospitals in Winnipeg, Canada to validate the accuracy of inpatient hospital diagnosis codes at identifying presentations for self-harm and suicide attempts. The Columbia Classification Algorithm of Suicide Assessment (C-CASA) was used as the gold standard...
February 24, 2017: International Journal of Methods in Psychiatric Research
https://www.readbyqxmd.com/read/28232919/investigation-of-the-plausibility-of-5-alpha-reductase-inhibitor-syndrome
#4
REVIEW
Raymond Fertig, Jerry Shapiro, Wilma Bergfeld, Antonella Tosti
Postfinasteride syndrome (PFS) is a term recently coined to characterize a constellation of reported undesirable side effects described in postmarketing reports and small uncontrolled studies that developed during or after stopping finasteride treatment, and persisted after drug discontinuation. Symptoms included decreased libido, erectile dysfunction, sexual anhedonia, decreased sperm count, gynecomastia, skin changes, cognitive impairment, fatigue, anxiety, depression, and suicidal ideation. The aim of this study is to review the existing medical literature for evidence-based research of permanent sexual dysfunction and mood changes during treatment with 5-alpha-reductase inhibitors including finasteride and dutasteride...
January 2017: Skin Appendage Disorders
https://www.readbyqxmd.com/read/28232817/analysis-of-audiometric-differences-of-patients-with-and-without-tinnitus-in-a-large-clinical-database
#5
Dominik Gollnast, Konstantin Tziridis, Patrick Krauss, Achim Schilling, Ulrich Hoppe, Holger Schulze
Human hearing loss (HL) and comorbidities like tinnitus pose serious problems for people's daily life, which in most severe cases may lead to social isolation, depression, and suicide. Here, we investigate the relationship between hearing deficits and tinnitus. To this end, we conducted a retrospective study on anonymized pure tone and speech audiometric data from patients of the ENT hospital Erlangen in which we compare audiometric data between patients with and without tinnitus. Overall data from 37,661 patients with sensorineural (SHL) or conductive HL (CHL) with (T, 9...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28232274/corpus-callosum-volumes-in-bipolar-disorders-and-suicidal-vulnerability
#6
Anthony J Gifuni, Emilie Olié, Yang Ding, Fabienne Cyprien, Emmanuelle le Bars, Alain Bonafé, Philippe Courtet, Fabrice Jollant
Reduced size of the corpus callosum (CC) has been associated with bipolar disorders and suicidality. Here, we aimed at investigating the relative independence of these associations in a large sample of patients. Two samples of males and females totaling 209 euthymic participants were recruited, including 72 patients with a major depressive disorder, 64 with bipolar disorders and 73 healthy controls. Among patients, 61 had a lifetime history of suicide attempt and 75 had none. Structural scans were acquired with 1...
February 10, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28231627/factors-predicting-recovery-from-suicide-in-attempted-suicide-patients
#7
Fan-Ko Sun, Chu-Yun Lu, Yun Shan Tseng, Chun-Ying Chiang
AIMS AND OBJECTIVES: The aim of this study was to explore the factors predicting suicide recovery and to provide guidance for healthcare professionals when caring for individuals who have attempted suicide. BACKGROUND: The high rate of suicide is a global health problem. Suicide prevention has become an important issue in contemporary mental health. Most suicide research has focused on suicidal prevention and care. There is a lack of research on the factors predicting suicidal recovery DESIGN: A cross-sectional design was adopted...
February 23, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28231481/the-influence-of-personality-traits-and-emotional-and-behavioral-problems-on-repetitive-nonsuicidal-self-injury-in-a-school-sample
#8
Janine Lüdtke, Benedict Weizenegger, Rachel Rauber, Brigitte Contin, Tina In-Albon, Marc Schmid
BACKGROUND: Nonsuicidal self-injury (NSSI) is highly prevalent among adolescents and associated with various mental health problems and suicidality. Previous studies have found that certain personality traits are related to NSSI behavior, however only few studies examined personality traits in adolescents with NSSI. Our study aimed to assess the relationship between personality traits and emotional and behavioral problems in predicting repetitive NSSI among adolescents from a school sample...
February 14, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28230897/unnatural-and-violent-death-in-cases-with-high-blood-alcohol-concentration-autopsy-study
#9
Danica Cvetković, Vladimir Živković, Vera Lukić, Slobodan Nikolić
The use of alcohol increases the risk of dying from unnatural or violent causes. The presented study explored the distribution of age, gender, cause, and circumstances of death in persons who died in an unnatural and violent manner, with a blood alcohol concentration (BAC) higher than 0.3 g/dL, and where the cause of death was not alcohol intoxication. We defined the control (0 < BAC < 0.3 g/dL) and study (BAC ≥ 0.3 g/dL) groups, as in subjects with these concentrations, there is a significant risk of gross intoxication, stupor, and death...
February 23, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28230751/the-feasibility-of-embedding-data-collection-into-the-routine-service-delivery-of-a-multi-component-program-for-high-risk-young-people
#10
Alice Knight, Alys Havard, Anthony Shakeshaft, Myfanwy Maple, Mieke Snijder, Bernie Shakeshaft
BACKGROUND: There is little evidence about how to improve outcomes for high-risk young people, of whom Indigenous young people are disproportionately represented, due to few evaluation studies of interventions. One way to increase the evidence is to have researchers and service providers collaborate to embed evaluation into the routine delivery of services, so program delivery and evaluation occur simultaneously. This study aims to demonstrate the feasibility of integrating best-evidence measures into the routine data collection processes of a service for high-risk young people, and identify the number and nature of risk factors experienced by participants...
February 20, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28230653/suicides-by-jumping-off-istanbul-bridges-linking-asia-and-europe
#11
Ayşe Yurtseven, İbrahim Üzün, Murat Nihat Arslan
AIM: The aim of this study was to determine the injury spectrum and characteristics of people who committed suicide by jumping into water from the July 15th Martyrs Bridge and Fatih Sultan Mehmet Bridges in Istanbul, Turkey. METHODS: This study included all of the jumpers from the July 15th Martyrs Bridge and Fatih Sultan Mehmet Bridge who were autopsied by the Council of Forensic Medicine, Istanbul Morgue Department, between 2000 and 2013. All of the data were collected from archived case files...
February 23, 2017: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/28230577/suicide-and-suicide-attempts-on-hospital-grounds-and-clinic-areas
#12
Peter D Mills, Bradley V Watts, Robin R Hemphill
OBJECTIVES: The goal of this study was to describe suicide and suicide attempts that occurred while the patient was on hospital grounds, common spaces, and clinic areas using root cause analysis (RCA) reports of these events in a national health care organization in the United States. METHOD: This is an observational review of all RCA reports of suicide and suicide attempts on hospital grounds, common spaces, and clinic areas in our system between December 1, 1999, and December 31, 2014...
February 22, 2017: Journal of Patient Safety
https://www.readbyqxmd.com/read/28230432/nursing-children-and-young-people-what-mental-health-training-is-required
#13
Leah Thomas
AIM: The aim of this research was to investigate the views of children and young people's nurses on the mental health training they had received and what recommendations they would make for future staff training. METHOD: Nine such nurses who had experience of nursing young people following self-harm or a suicide attempt were recruited. Data were collected using individual 45-minute semi-structured interviews and analysed using interpretative phenomenological analysis...
February 23, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/28230051/cellular-senescence-mediates-fibrotic-pulmonary-disease
#14
Marissa J Schafer, Thomas A White, Koji Iijima, Andrew J Haak, Giovanni Ligresti, Elizabeth J Atkinson, Ann L Oberg, Jodie Birch, Hanna Salmonowicz, Yi Zhu, Daniel L Mazula, Robert W Brooks, Heike Fuhrmann-Stroissnigg, Tamar Pirtskhalava, Y S Prakash, Tamara Tchkonia, Paul D Robbins, Marie Christine Aubry, João F Passos, James L Kirkland, Daniel J Tschumperlin, Hirohito Kita, Nathan K LeBrasseur
Idiopathic pulmonary fibrosis (IPF) is a fatal disease characterized by interstitial remodelling, leading to compromised lung function. Cellular senescence markers are detectable within IPF lung tissue and senescent cell deletion rejuvenates pulmonary health in aged mice. Whether and how senescent cells regulate IPF or if their removal may be an efficacious intervention strategy is unknown. Here we demonstrate elevated abundance of senescence biomarkers in IPF lung, with p16 expression increasing with disease severity...
February 23, 2017: Nature Communications
https://www.readbyqxmd.com/read/28229246/psychological-well-being-as-a-predictor-of-casual-sex-relationships-and-experiences-among-adolescents-a-short-term-prospective-study
#15
Sophie Dubé, Francine Lavoie, Martin Blais, Martine Hébert
Psychological characteristics may predispose youths to engage in casual sex relationships and experiences (CSREs). Using a prospective longitudinal design and in a subsample of 2601 high school students in the province of Québec, we explored possible shifts in engaging in one-night stands (ONSs) and friends with benefits (FWB) relationships over a 6-month period among sexually active adolescents. We also examined the relationships among well-being predictors (psychological distress, self-esteem, suicidal ideation, and alcohol and drug consumption) and these shifts while exploring possible gender differences...
February 22, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/28229240/microglia-in-the-dorsal-raphe-nucleus-plays-a-potential-role-in-both-suicide-facilitation-and-prevention-in-affective-disorders
#16
Ralf Brisch, Johann Steiner, Christian Mawrin, Marta Krzyżanowska, Zbigniew Jankowski, Tomasz Gos
An involvement of the central serotonergic system has constantly been reported in the pathogenesis of suicide. The dorsal raphe nucleus (DRN) is the main source of serotonergic innervation of forebrain limbic structures disturbed in suicidal behaviour, in which an abnormal microglia reaction seems to play a role. In our present study, the density of microglia immunostained for the HLA-DR antigen was evaluated in the DRN. These analyses were carried out on paraffin-embedded brains from 24 suicidal and 21 non-suicidal patients; among them, 27 depressed (15 major depressive disorder and 12 bipolar disorder) and 18 schizophrenia (9 residual and 9 paranoid) patients and 22 matched controls without mental disorders...
February 22, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28228633/relationship-between-geographical-characteristics-and-suicide-rate-in-wakayama-prefecture-its-visualization-using-geographic-information-system-and-consideration-on-the-index-of-regional-disparities
#17
Mayumi Oka, Takafumi Kubota, Hiroe Tsubaki, Keita Yamauchi, Mikio Arita
No abstract text is available yet for this article.
2017: [Nihon Kōshū Eisei Zasshi] Japanese Journal of Public Health
https://www.readbyqxmd.com/read/28228065/a-linguistic-analysis-of-suicide-related-twitter-posts
#18
Bridianne O'Dea, Mark E Larsen, Philip J Batterham, Alison L Calear, Helen Christensen
BACKGROUND: Suicide is a leading cause of death worldwide. Identifying those at risk and delivering timely interventions is challenging. Social media site Twitter is used to express suicidality. Automated linguistic analysis of suicide-related posts may help to differentiate those who require support or intervention from those who do not. AIMS: This study aims to characterize the linguistic profiles of suicide-related Twitter posts. METHOD: Using a dataset of suicide-related Twitter posts previously coded for suicide risk by experts, Linguistic Inquiry and Word Count (LIWC) and regression analyses were conducted to determine differences in linguistic profiles...
February 23, 2017: Crisis
https://www.readbyqxmd.com/read/28228064/a-mapping-study-on-the-internet-and-suicide
#19
Karolina Krysinska, Michael Westerlund, Thomas Niederkrotenthaler, Karl Andriessen, Vladimir Carli, Gergö Hadlaczky, Benedikt Till, Danuta Wasserman
BACKGROUND: Since the mid-1990s concerns have been raised regarding the possible links between suicide and the Internet, especially among adolescents and young adults. AIMS: To identify the nature and extent of the scientific publications, especially original research studies, on suicide and the Internet, and to investigate how the field has developed over time. In particular, this mapping study looks at types of publications, topic areas, focus of original research papers, and suicide-related variables of interest in publications...
February 23, 2017: Crisis
https://www.readbyqxmd.com/read/28228063/psychiatric-consultation-and-referral-of-persons-who-have-attempted-suicide
#20
Marc Roelands, Reginald Deschepper, Johan Bilsen
BACKGROUND: Persons who have attempted suicide are often admitted to a hospital's emergency department (ED). The risk of them repeating their attempt is lower if they have had access to a psychiatrist in hospital and had been referred to mental health care services. However, the literature suggests this is often lacking. AIMS: To describe perceived barriers to and supportive factors for psychiatric consultation and appropriate referral of suicide attempters in the ED...
February 23, 2017: Crisis
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