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cardiac risk factor

Monica M Gaudier-Diaz, Adam H Haines, Ning Zhang, A Courtney DeVries
Social isolation presents a risk factor and worsens outcome to cerebrovascular diseases; however, the underlying mechanisms remain underspecified. This study examines the effect of social environment on microglial reactivity after global cerebral ischemia, to test the hypothesis that social isolation leads to greater microglial responses. Adult female and male mice were pair-housed or socially isolated for one week prior to cardiac arrest/cardiopulmonary resuscitation (CA/CPR) or the sham procedure, and following either 2 or 24 h of reperfusion, microglia samples were enriched and analyzed for gene expression...
June 19, 2018: Physiology & Behavior
Demilade Adedinsewo, Oluwatosin Omole, Oludamilola Oluleye, Itse Ajuyah, Fred Kusumoto
Data on cardiovascular disease, including arrhythmias, in Africa is limited. However, the burden of cardiovascular disease appears to be on the rise. Recent global data suggests an increase in atrial fibrillation rates despite declining rates of rheumatic heart disease. Atrial fibrillation is also associated with increased mortality in Africa. Current management with medical therapy is sub-optimal and ablation procedures, inaccessible. Atrial fibrillation is also an independent risk factor for death in patients with rheumatic heart disease...
June 22, 2018: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
Derek M Culnan, Rajiv Sood
Burn injuries generate multisystem physiological derangements. The authors present a case series of three patients developing acute coronary syndrome (ACS) stemming from coronary vasospasm (CVS) over a course of 5 months. This etiology of ACS is significant as it has previously not been described in burn patients and requires a different management algorithm than vaso-occlusive disease. All patients were admitted to a single accredited burn unit. Burn mechanisms were flash burn, chemical fire, and house fire...
December 4, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
Wolfgang Lieb, Ramachandran S Vasan
Longitudinal, well phenotyped, population-based cohort studies offer unique research opportunities in the context of genome-wide association studies (GWAS), including GWAS for new-onset (incident) cardiovascular disease (CVD) events, the assessment of gene x lifestyle interactions, and evaluating the incremental predictive utility of genetic information in apparently healthy individuals. Furthermore, comprehensively phenotyped community-dwelling samples have contributed to GWAS of numerous traits that reflect normal organ function (e...
2018: Frontiers in Cardiovascular Medicine
Mahek Shah, Brijesh Patel, Byomesh Tripathi, Manyoo Agarwal, Soumya Patnaik, Pradhum Ram, Shantanu Patil, Jooyoung Shin, Ulrich P Jorde
BACKGROUND: Cardiogenic shock (CS) in absence of acute myocardial infarction (AMI) has significant morbidity and mortality. This population of patients has been excluded from prior major randomized trials and observational studies. METHODS: We included patients with CS in absence of AMI from the 2013-14 HCUP's National Readmission Database. 30-day readmissions were studied and etiology for readmission was identified by using ICD-9CM codes in primary diagnosis field...
June 10, 2018: International Journal of Cardiology
Cosmo Godino, Andrea Scotti, Maurizio Taramasso, Marianna Adamo, Marco Russo, Mauro Chiarito, Francesco Melillo, Alessandro Beneduce, Carlo Andrea Pivato, Luca Arrigoni, Evelina Toscano, Anna Salerno, Alberto Cappelletti, Valeria Magni, Stefano Stella, Gabriele Fragasso, Matteo Montorfano, Eustachio Agricola, Federica Ettori, Alberto Margonato, Francesco Maisano, Antonio Colombo
BACKGROUND: MitraClip implantation has evolved as a new tool for treatment of inoperable or high-risk patients with severe functional mitral regurgitation (FMR) due to dilated cardiomyopathy (DCM). Limited data are available regarding MitraClip outcomes comparing patients with ischemic and non-ischemic DCM. METHODS: From 2008 to 2016, 314 patients received MitraClip for FMR at four institutions: Brescia, Zurich and Milan. Patients were stratified according to MR aetiology in non-ischemic FMR (n = 99) and ischemic FMR (n = 215)...
June 12, 2018: International Journal of Cardiology
Filippo Sanfilippo, Alberto Noto, Gaetano J Palumbo, Mariachiara Ippolito, Mariapia Gagliardone, Maria Scarlata, Elena Bignami, Fabio Sangalli, Sergio Cattaneo, Ilaria Blangetti, Sabino Scolletta, Alessandro Locatelli, Luigi Tritapepe, Ferdinando L Lorini, Antonio Arcadipane
OBJECTIVE: There is increasing burnout incidence among medical disciplines, and physicians working in emergency settings seem at higher risk. Cardiac anesthesiology is a stressful anesthesiology subspecialty dealing with high-risk patients. The authors hypothesized a high risk of burnout in cardiac anesthesiologists. DESIGN: National survey conducted on burnout SETTING: Italian cardiac centers. PARTICIPANTS: Cardiac anesthesiologists. INTERVENTIONS: The authors administered via email an anonymous questionnaire divided into 3 parts...
May 16, 2018: Journal of Cardiothoracic and Vascular Anesthesia
Chloe E Bird, Michael Manocchia, Brooke Tomblin, Peggy Payne, Mahesh Kulakodlu, Emily Iacolo, Allen M Fremont
BACKGROUND: Prior research documents gender gaps in cardiovascular risk management, with women receiving poorer quality routine care on average, even in managed care systems. Although population health management tools and quality improvement efforts have led to better overall care quality and narrowing of racial/ethnic gaps for a variety of measures, we sought to quantify persistent gender gaps in cardiovascular risk management and to assess the performance of routinely used commercial population health management tools in helping systems narrow gender gaps...
June 1, 2018: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
Tilman Ziegler, Andrea Bähr, Andrea Howe, Katharina Klett, Wira Husada, Christian Weber, Karl-Ludwig Laugwitz, Christian Kupatt, Rabea Hinkel
Translations of new therapeutic options for cardiovascular disease from animal studies into a clinical setting have been hampered, in part by an improper reflection of a relevant patient population in animal models. In this study, we investigated the impact of thymosin β4 (Tβ4), which promotes collateralization and capillarization, during hypercholesterolemia, a known risk factor of coronary artery disease. Initial in vitro results highlighted an improved endothelial cell function upon Tβ4 treatment under control conditions and during hypercholesterolemic stress (scratch area [pixels]: oxidized low-density lipoprotein [oxLDL], 191,924 ± 7,717; and oxLDL + Tβ4, 105,621 ± 11,245)...
June 19, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
Svetlana Lions, Robert Dragu, Yoav Carsenty, Robert Zukermann, Doron Aronson
PURPOSE: We aimed to investigate the factors that modulate the extent of QTc prolongation and potential arrhythmogenic consequences during mild therapeutic hypothermia (MTH). METHODS: We studied 205 patients after out-of-hospital cardiac arrest (131 underwent MTH). QTc was measured at baseline, 3h, 6h, 12h, 24h (end of hypothermia), 48h and 72h, and ventricular arrhythmias quantified. RESULTS: During MTH, the QTc interval increased progressively peaking at 12h (mean increase 42ms, 95% CI 30-55)...
August 2018: Journal of Critical Care
Carole Maupain, Nicolas Badenco, Françoise Pousset, Xavier Waintraub, Guillaume Duthoit, Thomas Chastre, Caroline Himbert, Jean-Louis Hébert, Robert Frank, Françoise Hidden-Lucet, Estelle Gandjbakhch
OBJECTIVES: The purpose of this study was to identify clinical factors associated with arrhythmic events and sudden cardiac death (SCD), and to evaluate the prognostic value of electrophysiological study (EPS) in arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) patients without implantable cardioverter-defibrillators (ICDs). BACKGROUND: ARVC/D is an inherited cardiomyopathy characterized by a risk of SCD. Few studies have evaluated predictive factors of ventricular arrhythmias (VAs) in patients without ICDs...
June 2018: JACC. Clinical Electrophysiology
Huong Nguyen-Thu, Yoshiaki Ohyama, Ayako Taketomi-Takahashi, Tien Nguyen-Cong, Akio Sugimoto, Makito Sato, Hisako Sumiyoshi, Tetsuya Nakamura, Masahiko Kurabayashi, Yoshito Tsushima
PURPOSE: Age-related aortic changes are related to adverse cardiac remodeling and reduced cardiac function. Here, we aim to assess the correlations between aortic arch width (AAW) and left ventricular (LV) remodeling and LV function as well as coronary artery calcification (CAC). MATERIALS AND METHODS: This retrospective study included 194 patients (ages, 67±12 y) who underwent both coronary computed tomography angiography and echocardiography. The AAW is defined as the longest width between the ascending and descending aorta on a transaxial noncontrast coronary computed tomography angiography image at the level of the pulmonary artery bifurcation...
July 2018: Journal of Thoracic Imaging
S Marchetta, R Dulgheru, C Oury, F Frippiat, P Lancellotti
Infective endocarditis is a rare disease that can lead to some diagnostic wandering because of its often nonspecific and polymorphic clinical manifestations. This latency is at the origin of severe cardiac and extra-cardiac complications, yet highly fatal. The clinician should always bear in mind the differential diagnosis of a patient with fever of undetermined origin, with risk factors for valve infection such as foreign material, and history recent invasive procedures (including dental procedures) or recent hospitalization...
May 2018: Revue Médicale de Liège
Chunhua Deng, Zhichao Zhang, Hongjun Li, Peng Bai, Xian Cao, Adrian Sandra Dobs
OBJECTIVE: To investigate associations between cardiovascular disease risk factors, including fasting glucose, cholesterol, high density lipoprotein cholesterol (HDL-c), LDL-c, blood pressure, body mass index (BMI), C-peptide, creatinine kinase, smoking, alcohol use, physical activity, C-reactive protein as well as homocysteine levels and cardiovascular events. METHODS: Data from 1545 men aged ≥40 years, with testosterone deficiency (TD) (<300 ng/dL) and non-TD (≥300 ng/dL) which were extracted from the National Health and Nutrition Examination Survey database 2011-2012 and analyzed...
June 20, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
E V Rosseĭkin, E E Kobzev, O V Popyl'kova, S S Durmanov, V V Bazylev
Death in patients with postinfarction aneurysms of the left ventricle (LV) is mainly caused by life-threatening ventricular arrhythmias - ventricular tachycardias (VTs) and ventricular fibrillations (VFs). Surgical reconstruction of the LV may potentially lead to disruption of the re-entry mechanism, lying at the basis of ventricular tachyarrhythmias. A series of authors demonstrated high efficacy of such procedures as endocardectomy and radiofrequency ablation of the borderline zone of the LV. But high incidence of relapses, difficulty detecting the localization of VT and performing radiofrequency ablation (RFA), as well as high incidence of spontaneous and induced VTs in patients with postinfarction aneurysms of the LV have preserved dissatisfaction with the currently existing techniques...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
Junhui Li, Xiaohua Sheng, Dongsheng Cheng, Feng Wang, Guihua Jian, Yongguang Li, Tao Xu, Xiaoxia Wang, Ying Fan, Niansong Wang
A high mean platelet volume (MPV) level has been demonstrated to predict poor clinical outcomes in patients with cardiovascular disease. However, the relationship between MPV and mortality in patients with acute cardiorenal syndrome (ACRS) is unknown. Therefore, we investigated the predictive value of MPV for in-hospital mortality of patients with ACRS who received continuous renal replacement therapy (CRRT) in this study.We retrospectively analyzed the demographics, etiology, severity of illness, prognosis, and risk factors of ACRS patients who underwent CRRT in our hospital from January 2009 to December 2014...
June 2018: Medicine (Baltimore)
Stephanie G Waterhouse, Jeffrey E Vergales, Mark R Conaway, Laura Lee
OBJECTIVES: To assess the prevalence of central line-associated bloodstream infections in pediatric patients with and without chylothorax after cardiac surgery and identify risk factors that predict those patients at highest risk for developing a central line-associated bloodstream infection. DESIGN: Retrospective single-center cohort study. SETTING: A PICU located within a tertiary-care academic pediatric hospital. PATIENTS: All pediatric patients admitted to the PICU after cardiac surgery between 2008 and 2014...
June 19, 2018: Pediatric Critical Care Medicine
Andrew Todd Ham, Jill Mackey, Gary Semb
Continuous electroencephalography (CEEG) is chiefly performed at The Medical University of South Carolina (MUSC) for identifying seizures, including its refined use within the epilepsy monitoring unit (EMU) as a differentiator between epileptic and psychogenic etiologies. CEEG also provides critical data that carry implications outside the bounds of both epilepsy and psychogenic events, such as the characterization of unorthodox clinical phenomena that are of physiological (though nonepileptic) origins. Although nonepileptic events (NEEs) are primarily linked with psychogenic phenomena (conversion disorder, malingering) that can mimic epileptic activity, they, like seizures, have diverse semiologies and etiologies...
2018: Neurodiagnostic Journal
M Buvneshkumar, K R John, M Logaraj
Background: Depression among elderly is an important public health problem responsible for considerable morbidity and disability. Causes of depression are multifactorial and often preventable. As there was dearth of community studies in Tamil Nadu, the present study was undertaken. Objectives: The objective of this study is to estimate the prevalence of depression and to assess the factors which are associated with depression among elderly. Methods: A cross-sectional study was done from July 2014 to July 2015 among elderly in Kattankulathur block with a sample size of 690 by cluster sampling method...
April 2018: Indian Journal of Public Health
Yun Liu, Huan-Jia Shen, Xin-Qiu-Yue Wang, Hai-Qi Liu, Ling-Yun Zheng, Jian-Dong Luo
Cardiac hypertrophy is one of the major risk factors for chronic heart failure. The role of endophilinA2 (EndoA2) in clathrin-mediated endocytosis and clathrin-independent endocytosis is well documented. In the present study, we tested the hypothesis that EndoA2 protects against angiotensin II (Ang II)-induced cardiac hypertrophy by mediating intracellular angiotensin II type 1 receptor (AT1-R) trafficking in neonatal rat cardiomyocytes (NRCMs). Cardiac hypertrophy was evaluated by using cell surface area and quantitative RT-PCR (qPCR) analyses...
June 20, 2018: Journal of Cellular Biochemistry
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