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https://www.readbyqxmd.com/read/29656011/apoe-genotype-modifies-the-association-between-central-arterial-stiffening-and-cognition-in-older-adults
#1
Francis E Cambronero, Dandan Liu, Jacquelyn E Neal, Elizabeth E Moore, Katherine A Gifford, James G Terry, Sangeeta Nair, Kimberly R Pechman, Katie E Osborn, Timothy J Hohman, Susan P Bell, J David Sweatt, Thomas J Wang, Joshua A Beckman, John Jeffrey Carr, Angela L Jefferson
Arterial stiffening is associated with cognitive impairment and prodromal Alzheimer's disease. This study tested the interaction between arterial stiffening and an Alzheimer's disease genetic risk factor (apolipoprotein E [APOE] genotype) on cognition among older adults. Vanderbilt Memory & Aging Project participants with normal cognition (n = 162, 72 ± 7 years, 29% APOE-ε4 carrier) and mild cognitive impairment (n = 121, 73 ± 8 years, 42% APOE-ε4 carrier) completed neuropsychological assessment and cardiac MRI to assess aortic stiffening using pulse wave velocity (PWV, m/s)...
February 20, 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29655790/hdac11-deletion-reduces-fructose-induced-cardiac-dyslipidemia-apoptosis-and-inflammation-by-attenuating-oxidative-stress-injury
#2
Xiao-Di Fan, Lan-Lan Wan, Man Duan, Shan Lu
Diabetes mellitus (DM) is a risk factor for abnormal heart development, but the molecular mechanism remains obscure. Histone deacetylase 11 (HDAC11), the most recently identified histone deacetylase, is the sole member of class IV HDACs. However, its role in diabetic cardiac injury is still poorly understood. In the present study, we attempted to explore the effects of HDAC11 on fructose (Fru)-induced cardiac injury using the wild type (HDAC11+/+ ) and knockout (HDAC11-/- ) mice. The results indicated that HDAC11 was significantly expressed in human and mouse diabetic heart failure (DHF) hearts...
April 12, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29652543/cardioprotection-by-intermittent-hypoxia-conditioning-evidence-mechanisms-and-therapeutic-potential
#3
Robert T Mallet, Eugenia B Manukhina, Steven S Ruelas, James L Caffrey, H Fred Downey
The calibrated application of limited duration, cyclic, moderately intense hypoxia-reoxygenation increases cardiac resistance to ischemia-reperfusion stress. These intermittent hypoxic conditioning (IHC) programs consistently produce striking reductions in myocardial infarction and ventricular tachyarrhythmias following coronary artery occlusion and reperfusion, and in many cases, improved contractile function and coronary blood flow. These IHC protocols are fundamentally different from those used to simulate sleep apnea, a recognized cardiovascular risk factor...
April 13, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29652425/-risk-factors-for-cardiac-device-related-infection-during-two-year-follow-up-a-retrospective-analysis
#4
Maciej Kempa, Grzegorz Sławiński, Ewa Lewicka, Szymon Budrejko, Grzegorz Raczak
No abstract text is available yet for this article.
2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29652289/iatrogenic-atrio-esophageal-fistula-following-a-video-assisted-thoracoscopic-maze-procedure-is-esophageal-instrumentation-justified-even-when-the-diagnosis-is-equivocal
#5
Shvetank Agarwal, Muhammad Salman Tahir Janjua, Paramvir Singh, Nadine Odo, Manuel R Castresana
A 74-year-old female underwent an uneventful bilateral thoracoscopic maze procedure for persistent atrial fibrillation with continuous transesophageal echocardiographic (TEE) guidance. She presented six weeks later with persistent fever and focal neurological signs. Computed tomography of the thorax revealed air in the posterior LA, raising suspicion for an abscess versus an atrioesophageal fistula (AEF). Before undergoing an exploratory median sternotomy, an esophagogastroduodenoscopy (EGD) was performed by the surgeon to check for any esophageal pathology...
April 2018: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/29652277/factors-associated-with-delayed-cardiac-tamponade-after-cardiac-surgery
#6
Edgar Hernández Leiva, Marisol Carreño, Fernando Rada Bucheli, Alberto Cadena Bonfanti, Juan Pablo Umaña, Rodolfo José Dennis
Context: Cardiac tamponade (CT) following cardiac surgery is a potentially fatal complication and the cause of surgical reintervention in 0.1%-6% of cases. There are two types of CT: acute, occurring within the first 48 h postoperatively, and subacute or delayed, which occurs more than 48 h postoperatively. The latter does not show specific clinical signs, which makes it more difficult to diagnose. The factors associated with acute CT (aCT) are related to coagulopathy or surgical bleeding, while the variables associated with subacute tamponade have not been well defined...
April 2018: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/29652077/the-implications-of-cocaine-use-and-associated-behaviors-on-adverse-cv-outcomes-among-veterans-insights-from-the-va-clinical-assessment-reporting-and-tracking-cart-program
#7
Ateka Gunja, Maggie A Stanislawski, Anna E Barón, Thomas M Maddox, Steven M Bradley, Mladen I Vidovich
BACKGROUND: Cocaine use has been associated with adverse cardiovascular outcomes in patients with coronary artery disease. It is unclear if this association is due to direct effects of cocaine or other factors. METHODS: The Veterans Affairs cardiac catheterization database was used to identify Veterans undergoing coronary catheterization between 2007 and 2014. We analyzed association between cocaine use and 1-year all-cause mortality, myocardial infarction (MI), and cerebrovascular accident (CVA) among Veterans with obstructive CAD (N=122,035)...
April 13, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29650543/rbm20-mutations-induce-an-arrhythmogenic-dilated-cardiomyopathy-related-to-disturbed-calcium-handling
#8
Maarten M G van den Hoogenhof, Abdelaziz Beqqali, Ahmad S Amin, Ingeborg van der Made, Simona Aufiero, Mohsin A F Khan, Cees A Schumacher, Joeri A Jansweijer, Karin Y van Spaendonck-Zwarts, Carol Ann Remme, Johannes Backs, Arie O Verkerk, Antonius Baartscheer, Yigal M Pinto, Esther E Creemers
Background -Mutations in RBM20 cause a clinically aggressive form of dilated cardiomyopathy (DCM), with an increased risk of malignant ventricular arrhythmias. RBM20 is a splicing factor that targets multiple pivotal cardiac genes, such as Titin (TTN) and Calcium/calmodulin-dependent kinase II delta (CAMK2D). Aberrant TTN splicing is thought to be the main determinant of RBM20-induced DCM, but is not likely to explain the increased risk of arrhythmias. Here, we investigated the extent at which RBM20 mutation carriers have an increased risk of arrhythmias and explore the underlying molecular mechanism...
April 12, 2018: Circulation
https://www.readbyqxmd.com/read/29649615/fever-related-arrhythmic-events-in-the-multicenter-survey-on-arrhythmic-events-in-brugada-syndrome-sabrus
#9
Yoav Michowitz, Anat Milman, Georgia Sarquella-Brugada, Antoine Andorin, Jean Champagne, Pieter G Postema, Ruben Casado-Arroyo, Eran Leshem, Jimmy Jm Juang, Carla Giustetto, Jacob Tfelt-Hansen, Yanushi D Wijeyeratne, Christian Veltmann, Domenico Corrado, Sung-Hwan Kim, Pietro Delise, Shingo Maeda, Jean-Baptiste Gourraud, Frederic Sacher, Philippe Mabo, Yoshihide Takahashi, Tsukasa Kamakura, Takeshi Aiba, Giulio Conte, Aviram Hochstadt, Yuka Mizusawa, Michael Rahkovich, Elena Arbelo, Zhengrong Huang, Isabelle Denjoy, Carlo Napolitano, Ramon Brugada, Leonardo Calo, Silvia G Priori, Masahiko Takagi, Elijah R Behr, Fiorenzo Gaita, Gan-Xin Yan, Josep Brugada, Antoine Leenhardt, Arthur A M Wilde, Pedro Brugada, Kengo F Kusano, Kenzo Hirao, Gi-Byoung Nam, Vincent Probst, Bernard Belhassen
BACKGROUND: The literature on fever related arrhythmic events (AE) in Brugada syndrome (BrS) is currently limited to few case reports and small series. OBJECTIVE: The current study aims to describe the characteristics of fever-related AE in a large cohort of BrS patients. METHODS: SABRUS is a multicenter study on 678 BrS patients with first AE documented at time of aborted cardiac arrest (ACA) (n=426) or after prophylactic ICD implantation (n=252)...
April 9, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29649579/prognostic-value-of-nutrition-status-in-the-response-of-cardiac-resynchronization-therapy
#10
Belén Alvarez-Alvarez, Javier García-Seara, Moisés Rodríguez-Mañero, Diego Iglesias-Alvarez, Jose L Martínez-Sande, Rosa M Agra-Bermejo, Xesús A Fernández López, Laila González-Melchor, Francisco Gude Sampedro, Carla Díaz-Louzao, José R González-Juanatey
BACKGROUND: Cardiac resynchronization therapy (CRT) is indicated in symptomatic heart failure (HF) patients after achieving optimal medical therapy. However, there are still a large percentage of patients who do not respond to CRT. Malnutrition is a frequent comorbidity in patients with HF, and it is associated with a poorer prognosis. Here, we evaluate the nutritional status of patients assessed by Controlling Nutritional Status (CONUT) score and its association with structural remodeling and cardiovascular events...
April 9, 2018: Indian Pacing and Electrophysiology Journal
https://www.readbyqxmd.com/read/29648667/epidemiology-risk-factors-and-characteristics-of-pediatric-stroke-a-nationwide-population-based-study
#11
Kuo-Liang Chiang, Chen-Yang Cheng
Background: Stroke, classically characterized as an acute acquired neurological deficit, is an important leading cause of death and chronic morbidity in children. Aims: This study reported the period prevalence, incidence, and risk factors of pediatric stroke in Taiwan. Methods and Procedures: All Taiwan inhabitants aged 1 month to 18 years registered in the National Health Insurance Research Database (NHIRD) between 2010 and 2011 were enrolled in this study...
April 10, 2018: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29643338/causal-pathways-from-blood-pressure-to-larger-qrs-amplitudes-a-mendelian-randomization-study
#12
M Yldau Van Der Ende, Tom Hendriks, Dirk J Van Veldhuisen, Harold Snieder, Niek Verweij, Pim Van Der Harst
Abnormal QRS duration and amplitudes on the electrocardiogram are indicative of cardiac pathology and are associated with adverse outcomes. The causal nature of these associations remains uncertain and could be due to QRS abnormalities being a symptom of cardiac damage rather than a factor on the causal pathway. By performing Mendelian randomization (MR) analyses using summary statistics of genome wide association study consortia with sample sizes between 20,687 and 339,224 individuals, we aimed to determine which cardiovascular risk factors causally lead to changes in QRS duration and amplitude (Sokolow-Lyon, Cornell and 12-leadsum products)...
April 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29643156/indecho-study-cohort-study-investigating-birth-size-childhood-growth-and-young-adult-cardiovascular-risk-factors-as-predictors-of-midlife-myocardial-structure-and-function-in-south-asians
#13
Senthil K Vasan, Ambuj Roy, Viji Thomson Samuel, Belavendra Antonisamy, Santosh K Bhargava, Anoop George Alex, Bhaskar Singh, Clive Osmond, Finney S Geethanjali, Fredrik Karpe, Harshpal Sachdev, Kanhaiya Agrawal, Lakshmy Ramakrishnan, Nikhil Tandon, Nihal Thomas, Prasanna S Premkumar, Prrathepa Asaithambi, Sneha F X Princy, Sikha Sinha, Thomas Vizhalil Paul, Dorairaj Prabhakaran, Caroline H D Fall
INTRODUCTION: South Asians have high rates of cardiovascular disease (CVD) and its risk factors (hypertension, diabetes, dyslipidaemia and central obesity). Left ventricular (LV) hypertrophy and dysfunction are features of these disorders and important predictors of CVD mortality. Lower birth and infant weight and greater childhood weight gain are associated with increased adult CVD mortality, but there are few data on their relationship to LV function. The IndEcho study will examine associations of birth size, growth during infancy, childhood and adolescence and CVD risk factors in young adulthood with midlife cardiac structure and function in South Asian Indians...
April 10, 2018: BMJ Open
https://www.readbyqxmd.com/read/29642997/gender-differences-in-symptom-presentation-of-st-elevation-myocardial-infarction-an-observational-multicenter-survey-study
#14
Sofia Sederholm Lawesson, Rose-Marie Isaksson, Ingela Thylén, Maria Ericsson, Karin Ängerud, Eva Swahn
BACKGROUND: Symptom presentation has been sparsely studied from a gender perspective restricting the inclusion to ST elevation myocardial infarction (STEMI) patients. Correct symptom recognition is vital in order to promptly seek care in STEMI where fast reperfusion therapy is of utmost importance. Female gender has been found associated with atypical presentation in studies on mixed MI populations but it is unclear whether this is valid also in STEMI. OBJECTIVES: We assessed whether there are gender differences in symptoms and interpretation of these in STEMI, and if this is attributable to sociodemographic and clinical factors...
March 24, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29642691/high-risk-pci-how-to-define-it-today
#15
Vincenzo DE Marzo, Domenico D'Amario, Mattia Galli, Rocco Vergallo, Italo Porto
Before the percutaneous spread, the mortality rate of patients with coronary heart disease not suitable for cardiac surgery was markedly high. This limit has been progressively exceeded with the advent of minimally invasive approaches, which, although was initially intended exclusively for low risk patients, was then employed in complex patients often too compromised to undergo cardiac surgery. Given to the rising of high-risk population, due to an increase of patients with multiple chronic conditions linked to the best care offered, we are witnessing an expansion of the high-risk percutaneous coronary interventions (PCI) population...
April 11, 2018: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/29629485/has-the-time-come-to-be-more-aggressive-with-bariatric-surgery-in-obese-patients-with-chronic-systolic-heart-failure
#16
REVIEW
Amanda R Vest
PURPOSE OF REVIEW: Obesity is a strong risk factor for the development of heart failure (HF). Diet, exercise, and weight-loss pharmacotherapies have limited potential to achieve significant and sustainable weight loss, especially in patients with symptomatic systolic HF. This review seeks to determine the role of bariatric surgery for patients with systolic HF and obesity. RECENT FINDINGS: Bariatric surgeries such as the laparoscopic sleeve gastrectomy (LSG) and Roux-en-Y gastric bypass (RYGB) represent the most successful long-term strategy for achieving weight loss and diabetes and hypertension remission in the general obese population...
April 8, 2018: Current Heart Failure Reports
https://www.readbyqxmd.com/read/29629297/influences-of-pinpoint-plantar-long-wavelength-infrared-light-irradiation-stress-free-therapy-on-chorioretinal-hemodynamics-atherosclerosis-factors-and-vascular-endothelial-growth-factor
#17
Keisou Ishimaru, Takuma Nakajima, Yoshihisa Namiki, Kenji Ryotokuji
Background: We previously reported that pinpoint plantar long-wavelength infrared light irradiation (stress-free therapy; SFT) is useful for alleviating insulin resistance and improving intracranial blood flow in patients with type 2 diabetes mellitus. This study was undertaken to evaluate the influences of SFT on chorioretinal hemodynamics (retinal artery and vein blood flows) as well as atherosclerosis-related factors (TG, LDL-C) and VEGF in patients with dyslipidemia. Methods: Four patients with dyslipidemia received 15-minute irradiation with a stress-free apparatus (far-infrared wavelength, 30 mW)...
March 2018: Integrative Medicine Research
https://www.readbyqxmd.com/read/29629255/obesity-cardiac-remodeling-and-metabolic-profile-validation-of-a-new-simple-index-beyond-body-mass-index
#18
Francesco Antonini-Canterin, Concetta Di Nora, Stefano Poli, Lina Sparacino, Iulian Cosei, Andreea Ravasel, Andreea Catarina Popescu, Bogdan Alexandru Popescu
Aim: The body mass index (BMI), the most used anthropometric index of obesity, has an important limitation, not taking into consideration the distribution of body fat. We developed a new simple index: the waist-corrected BMI (wBMI), calculated as waist circumference (WC) × BMI. The study aim was to assess the role of wBMI, compared to BMI, WC, and Waist-to-Height Ratio (WHtR) in predicting abnormal cardiac geometry, insulin resistance, increased arterial stiffness, and dyslipidemia. Methods: This was a cross-sectional study that included 805 patients referred to our Department of Preventive Cardiology for risk factors evaluation and treatment...
January 2018: Journal of Cardiovascular Echography
https://www.readbyqxmd.com/read/29629020/diagnosis-treatment-and-prevention-of-cardiovascular-toxicity-related-to-anti-cancer-treatment-in-clinical-practice-an-opinion-paper-from-the-working-group-on-cardio-oncology-of-the-korean-society-of-echocardiography
#19
REVIEW
Hyungseop Kim, Woo-Baek Chung, Kyoung Im Cho, Bong-Joon Kim, Jeong-Sook Seo, Seong-Mi Park, Hak Jin Kim, Ju-Hee Lee, Eun Kyoung Kim, Ho-Joong Youn
Cardiovascular (CV) toxicity associated with anti-cancer treatment is commonly encountered and raises critical problems that often result in serious morbidity or mortality. Most cardiac toxicities are related to the cumulative dose of chemotherapy; however, the type of chemotherapy, concomitant agents, and/or conventional CV risk factors have been frequently implicated in CV toxicity. Approximately half of the patients exhibiting CV toxicity receive an anthracycline-based regimen. Therefore, serologic biomarkers or cardiac imagings are important during anti-cancer treatment for early detection and the decision of appropriate management of cardiotoxicity...
March 2018: Journal of Cardiovascular Ultrasound
https://www.readbyqxmd.com/read/29628582/predictors-and-outcomes-of-postoperative-pulmonary-complications-following-abdominal-surgery-in-a-south-indian-population
#20
Lakshmi Kumar, Keerthi N Satheesan, Sunil Rajan, Bindu K Vasu, Jerry Paul
Background: Postoperative pulmonary complications (PPC) following abdominal surgery are associated with increased morbidity and poorer outcomes. We prospectively examined risk factors associated with the development of PPC in patients undergoing abdominal surgery. Aims: The primary outcome was to determine the association of predefined risk factors in the prediction of PPC after abdominal surgery. Secondary outcomes were evaluation of outcomes of PPC. Setting and Design: This was a prospective study conducted in the gastrosurgical and urological units of a tertiary care referral hospital in patients undergoing abdominal surgery over a period of 6 months (November 2015-April 2016)...
January 2018: Anesthesia, Essays and Researches
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