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https://www.readbyqxmd.com/read/29775879/catalytic-degradation-of-organophosphorous-nerve-agent-simulants-by-polymer-beads-graphene-oxide-with-organophosphorus-hydrolase-like-activity-based-on-rational-design-of-functional-bimetallic-nuclear-ligand
#1
Xuejuan Ma, Lin Zhang, Mengfan Xia, Xiaohong Zhang, Yaodong Zhang
The degradation of organophosphorous nerve agents is of primary concern due to the severe toxicity of these agents. Based on the active center of organophosphorus hydrolase (OPH), a bimetallic nuclear ligand, (5-vinyl-1,3-phenylene)bis(di(1H-imidazol-2-yl) methanol) (VPIM), was designed and synthesized, which contains four imidazole groups to mimic the four histidines at OPH active center. By grafting VPIM on graphene oxide (GO) surface via polymerization, the VPIM-polymer beads@GO was produced. The obtained OPH mimics has an impressive activity in dephosphorylation reactions (turnover frequency (TOF) towards paraoxon: 2...
May 15, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29775852/biomimetic-magnetoelectric-nanocrystals-synthesized-by-polymerization-of-heme-as-advanced-nanomaterials-for-biosensing-application
#2
Jeong Eun Hyeon, Da Woon Jeong, Young Jin Ko, Seung Wook Kim, Chulhwan Park, Sung Ok Han
Regardless of the malaria disease risk, the malaria parasite Plasmodium falciparum has an interesting mechanism. During its growth within the red blood cell, toxic free heme is converted into an insoluble crystalline form called the malaria pigment, or hemozoin. In particular, natural hemozoin nanocrystals can provide multiple applications in biosensing fields for health care and diagnosis as similar to artificial metal nanoparticles. In this study, the heme was biologically synthesized and polymerized by Corynebacterium glutamicum and final polymer was applied as a biomimetic conductive biopolymer...
May 10, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29775504/biomimetic-supramolecular-fibers-exhibit-water-induced-supercontraction
#3
Yuchao Wu, Darshil U Shah, Baoyuan Wang, Ji Liu, Xiaohe Ren, Michael H Ramage, Oren A Scherman
Spider silk is a fascinating material, combining high strength and elasticity that outperforms most synthetic fibers. Another intriguing feature of spider silk is its ability to "supercontract," shrinking up to 50% when exposed to water. This is likely on account of the entropy-driven recoiling of secondary structured proteins when water penetrates the spider silk. In contrast, humidity-driven contraction in synthetic fibers is difficult to achieve. Here, inspired by the spider silk model, a supercontractile fiber (SCF), which contracts up to 50% of its original length at high humidity, comparable to spider silk, is reported...
May 18, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29774068/platelet-camouflaged-nanococktail-simultaneous-inhibition-of-drug-resistant-tumor-growth-and-metastasis-via-a-cancer-cells-and-tumor-vasculature-dual-targeting-strategy
#4
Lijia Jing, Haijing Qu, Dongqi Wu, Chaojian Zhu, Yongbo Yang, Xing Jin, Jian Zheng, Xiangsheng Shi, Xiufeng Yan, Yang Wang
Multidrug resistance (MDR) poses a great challenge to cancer therapy. It is difficult to inhibit the growth of MDR cancer due to its chemoresistance. Furthermore, MDR cancers are more likely to metastasize, causing a high mortality among cancer patients. In this study, a nanomedicine RGD-NPVs@MNPs/DOX was developed by encapsulating melanin nanoparticles (MNPs) and doxorubicin (DOX) inside RGD peptide (c(RGDyC))-modified nanoscale platelet vesicles (RGD-NPVs) to efficiently inhibit the growth and metastasis of drug-resistant tumors via a cancer cells and tumor vasculature dual-targeting strategy...
2018: Theranostics
https://www.readbyqxmd.com/read/29773227/de1sign-of-synthetic-extracellular-matrices-for-probing-breast-cancer-cell-growth-using-robust-cyctocompatible-nucleophilic-thiol-yne-addition-chemistry
#5
Laura J Macdougall, Katherine L Wiley, April M Kloxin, Andrew P Dove
Controlled, three-dimensional (3D) cell culture systems are of growing interest for both tissue regeneration and disease, including cancer, enabling hypothesis testing about the effects of microenvironment cues on a variety of cellular processes, including aspects of disease progression. In this work, we encapsulate and culture in three dimensions different cancer cell lines in a synthetic extracellular matrix (ECM), using mild and efficient chemistry. Specifically, harnessing the nucleophilic addition of thiols to activated alkynes, we have created hydrogel-based materials with multifunctional poly(ethylene glycol) (PEG) and select biomimetic peptides...
May 7, 2018: Biomaterials
https://www.readbyqxmd.com/read/29772711/biomimetic-superhydrophobic-hollowed-out-pyramid-surface-based-on-self-assembly
#6
Weipeng Luo, Bin Yu, Dingbang Xiao, Meng Zhang, Xuezhong Wu, Guoxi Li
In this paper, we present a periodic hollowed-out pyramid microstructure with excellent superhydrophobicity. In our approach, T-topping pillars and capillary-induced self-assembly methods were combined with the photolithography process to fabricate a hollowed-out pyramid structure. First, a wideband ultraviolet source without a filter was used to fabricate the T-topping pillars during the exposure process; then, the evaporation-induced assembly collapsed the pillars and formed the hollowed-out pyramid structure...
May 16, 2018: Materials
https://www.readbyqxmd.com/read/29770323/dental-mesenchymal-stem-cell-based-translational-regenerative-dentistry-from-artificial-to-biological-replacement
#7
REVIEW
Mona K Marei, Rania M El Backly
Dentistry is a continuously changing field that has witnessed much advancement in the past century. Prosthodontics is that branch of dentistry that deals with replacing missing teeth using either fixed or removable appliances in an attempt to simulate natural tooth function. Although such "replacement therapies" appear to be easy and economic they fall short of ever coming close to their natural counterparts. Complications that arise often lead to failures and frequent repairs of such devices which seldom allow true physiological function of dental and oral-maxillofacial tissues...
2018: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/29767959/stabilization-of-immobilized-enzymes-via-the-chaperone-like-activity-of-mixed-lipid-bilayers
#8
Andres F Chaparro Sosa, Daniel F Kienle, Rebecca M Falatach, Jessica Flanagan, Joel L Kaar, Daniel K Schwartz
Biomimetic lipid bilayers represent intriguing materials for enzyme immobilization, which is critical for many biotechnological applications. Here, through the creation of mixed lipid bilayers, the retention of immobilized enzyme structure and catalytic activity are dramatically enhanced. The enhancement in the retention of enzyme structure, which correlated with an increase in enzyme activity, is observed using dynamic single-molecule (SM) fluorescence methods. The results of SM analysis specifically show that lipid bilayers composed of mixtures of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) and 1,2-dioleoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (DOPG) stabilize the folded state of nitroreductase (NfsB) increasing the rate of re-folding relative to unfolding of enzyme molecules on the bilayer surface...
May 16, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29767196/strategies-for-directing-cells-into-building-functional-hearts-and-parts
#9
REVIEW
Mahboubeh Jafarkhani, Zeinab Salehi, Reza Kowsari-Esfahan, Mohammad Ali Shokrgozar, M Rezaa Mohammadi, Jayakumar Rajadas, Masoud Mozafari
The increasing population of patients with heart disease and the limited availability of organs for transplantation have encouraged multiple strategies to fabricate healthy implantable cardiac tissues. One of the main challenges in cardiac tissue engineering is to direct cell behaviors to form functional three-dimensional (3D) biomimetic constructs. This article provides a brief review on various cell sources used in cardiac tissue engineering and highlights the effect of scaffold-based signals such as topographical and biochemical cues and stiffness...
May 16, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29765407/effects-of-transplanted-heparin-poloxamer-hydrogel-combining-dental-pulp-stem-cells-and-bfgf-on-spinal-cord-injury-repair
#10
Lihua Luo, Abdullkhaleg Ali Albashari, Xiaoyan Wang, Ling Jin, Yanni Zhang, Lina Zheng, Jianjian Xia, Helin Xu, Yingzheng Zhao, Jian Xiao, Yan He, Qingsong Ye
Spinal cord injury (SCI) is one of serious traumatic diseases of the central nervous system and has no effective treatment because of its complicated pathophysiology. Tissue engineering strategy which contains scaffolds, cells, and growth factors can provide a promising treatment for SCI. Hydrogel that has 3D network structure and biomimetic microenvironment can support cellular growth and embed biological macromolecules for sustaining release. Dental pulp stem cells (DPSCs), derived from cranial neural crest, possess mesenchymal stem cell (MSC) characteristics and have an ability to provide neuroprotective and neurotrophic properties for SCI treatment...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29765405/recent-progress-of-fabrication-of-cell-scaffold-by-electrospinning-technique-for-articular-cartilage-tissue-engineering
#11
REVIEW
Yingge Zhou, Joanna Chyu, Mimi Zumwalt
As a versatile nanofiber manufacturing technique, electrospinning has been widely employed for the fabrication of tissue engineering scaffolds. Since the structure of natural extracellular matrices varies substantially in different tissues, there has been growing awareness of the fact that the hierarchical 3D structure of scaffolds may affect intercellular interactions, material transportation, fluid flow, environmental stimulation, and so forth. Physical blending of the synthetic and natural polymers to form composite materials better mimics the composition and mechanical properties of natural tissues...
2018: International Journal of Biomaterials
https://www.readbyqxmd.com/read/29764691/overview-of-silk-fibroin-use-in-wound-dressings
#12
REVIEW
Mehdi Farokhi, Fatemeh Mottaghitalab, Yousef Fatahi, Ali Khademhosseini, David L Kaplan
Recently, biomimetic wound dressings were introduced as potential replacements for treating skin injuries. Although there are some clinically available skin replacements, the range of wound types and locations necessitates a broader range of options for the clinic. Natural polymeric-based dressings are of central interest in this area due to their outstanding biocompatibility, biodegradability, low toxicity, and non-allergenic nature. Among them, silk fibroin (SF) has exceptional characteristics as a wound dressing...
May 12, 2018: Trends in Biotechnology
https://www.readbyqxmd.com/read/29763945/leishmanicidal-effects-of-piperlongumine-piplartine-and-its-putative-metabolites
#13
Fernanda de Lima Moreira, Thalita Bachelli Riul, Marcela de Lima Moreira, Alan Cesar Pilon, Marcelo Dias-Baruffi, Márcio S S Araújo, Norberto Peporine Lopes, Anderson R M de Oliveira
Piperlongumine is an amide alkaloid found in Piperaceae species that shows a broad spectrum of biological properties, including antitumor and antiparasitic activities. Herein, the leishmanicidal effect of piperlongumine and its derivatives produced by a biomimetic model using metalloporphyrins was investigated. The results showed that IC50 values of piperlongumine in promastigote forms of Leishmania infantum and Leishmania amazonensis were 7.9 and 3.3 µM, respectively. The IC50 value of piperlongumine in the intracellular amastigote form of L...
May 15, 2018: Planta Medica
https://www.readbyqxmd.com/read/29763524/separating-extreme-ph-gradients-using-amphiphilic-copolymer-membranes
#14
Lorena Ruiz-Pérez, Claire Hurley, Salvador Tomás, Giuseppe Battaglia
Polymeric vesicles, also called polymersomes, are highly efficient biomimetic systems. They can generate compartmentalized volumes at the nanoscale supported by synthetic amphiphilic membranes that closely mimic their biological counterparts. Membrane permeability and the ability to separate extreme pH gradients is a crucial condition a successful biomimetic system must meet. We show polymersomes formed by non-ionic polybutadiene-b-polyethylene oxide (PBd-b-PEO) amphiphilic block copolymers engineer robust and stable membranes that are able able to sustain pH gradients of 10 for a minimum of 8 days...
May 15, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/29760422/sculpting-and-fusing-biomimetic-vesicle-networks-using-optical-tweezers
#15
Guido Bolognesi, Mark S Friddin, Ali Salehi-Reyhani, Nathan E Barlow, Nicholas J Brooks, Oscar Ces, Yuval Elani
Constructing higher-order vesicle assemblies has discipline-spanning potential from responsive soft-matter materials to artificial cell networks in synthetic biology. This potential is ultimately derived from the ability to compartmentalise and order chemical species in space. To unlock such applications, spatial organisation of vesicles in relation to one another must be controlled, and techniques to deliver cargo to compartments developed. Herein, we use optical tweezers to assemble, reconfigure and dismantle networks of cell-sized vesicles that, in different experimental scenarios, we engineer to exhibit several interesting properties...
May 14, 2018: Nature Communications
https://www.readbyqxmd.com/read/29758601/long-ligands-reinforce-biological-adhesion-under-shear-flow
#16
Aleksey V Belyaev
In this work, computer modeling has been used to show that longer ligands allow biological cells (e.g., blood platelets) to withstand stronger flows after their adhesion to solid walls. A mechanistic model of polymer-mediated ligand-receptor adhesion between a microparticle (cell) and a flat wall has been developed. The theoretical threshold between adherent and non-adherent regimes has been derived analytically and confirmed by simulations. These results lead to a deeper understanding of numerous biophysical processes, e...
April 2018: Physical Review. E
https://www.readbyqxmd.com/read/29756630/a-biomimetic-microfluidic-model-to-study-signalling-between-endothelial-and-vascular-smooth-muscle-cells-under-hemodynamic-conditions
#17
Nicole C A van Engeland, Andreas M A O Pollet, Jaap M J den Toonder, Carlijn V C Bouten, Oscar M J A Stassen, Cecilia M Sahlgren
Cell signalling and mechanics influence vascular pathophysiology and there is an increasing demand for in vitro model systems that enable examination of signalling between vascular cells under hemodynamic conditions. Current 3D vessel wall constructs do not recapitulate the mechanical conditions of the native tissue nor do they allow examination of cell-cell interactions under relevant hemodynamic conditions. Here, we describe a 3D microfluidic chip model of arterial endothelial and smooth muscle cells where cellular organization, composition and interactions, as well as the mechanical environment of the arterial wall are mimicked...
May 14, 2018: Lab on a Chip
https://www.readbyqxmd.com/read/29756586/the-review-of-nanomaterials-inducing-the-differentiation-of-stem-cells-into-chondrocyte-phenotypes-in-cartilage-tissue-engineering
#18
Xueping Xie, Qi Zhang, Tengfei Zhou, Quanquan Ma, Liao JinFeng
Cartilage, as a nanostructured tissue, because of its awfully poor capacity for inherent regeneration and complete hierarchical structure, is severely difficult to regenerate after damages. Tissue engineering methods have provided great contribution for cartilage repair. Nanomaterials have special superiority in regulating stem cell behaviors due to their special mechanical and biological properties and biomimetic characteristics, therefore, they have been given great attention in tissue regeneration. Nanomaterials are divided into organic and inorganic nanomaterials...
May 11, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29756272/harnessing-human-decellularized-blood-vessel-matrices-and-cellular-construct-implants-to-promote-bone-healing-in-an-ex-vivo-organotypic-bone-defect-model
#19
Stefanie Inglis, Karl Heinrich Schneider, Janos M Kanczler, Heinz Redl, Richard O C Oreffo
Decellularized matrices offer a beneficial substitute for biomimetic scaffolds in tissue engineering. The current study examines the potential of decellularized placental vessel sleeves (PVS) as a periosteal protective sleeve to enhance bone regeneration in embryonic day 18 chick femurs contained within the PVS and cultured organotypically over a 10 day period. The femurs are inserted into decellularized biocompatibility-tested PVS and maintained in an organotypic culture for a period of 10 days. In femurs containing decellularized PVS, a significant increase in bone volume (p < 0...
May 14, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29756148/understanding-the-viral-load-during-the-synthesis-and-after-rebinding-of-virus-imprinted-particles-via-real-time-quantitative-pcr
#20
M Gast, S Kühner, H Sobek, B Mizaikoff
In the present study, virus imprinted particles have been synthesized for recognizing and specifically binding viruses. These materials may be used for biomimetic sensing schemes and for selective removal of virus particles. Virus imprinting procedures require careful optimization of the synthesis route for obtaining selective and efficiently binding imprinted materials. A remaining limitation has been a facile method for the quantification of the viral load during the imprinting process. Herein, human adenovirus (AdV) was selected as a model virus facilitating the development and application of a rapid virus quantification method based on a molecular biological approach...
May 14, 2018: Analyst
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