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https://www.readbyqxmd.com/read/29334363/macrophage-membrane-coated-iron-oxide-nanoparticles-for-enhanced-photothermal-tumor-therapy
#1
Qian-Fang Meng, Lang Rao, Minghui Zan, Ming Chen, Guang-Tao Yu, Xiaoyun Wei, Zhuhao Wu, Yue Sun, Shi Shang Guo, Xing-Zhong Zhao, Fu-Bing Wang, Wei Liu
Nanotechnology possesses the potential to revolutionize the diagnosis and treatment of tumors. The ideal nanoparticles used for in vivo cancer therapy should own long blood circulation and active cancer targeting. Additionally, they should be innoxious and invisible to the immune system. Here, we developed a biomimetic nanoplatform with the above properties for cancer therapy. Macrophage membranes were reconstructed into vesicles and then coated onto magnetic iron oxide nanoparticles (Fe3O4 NPs). Inherited from the Fe3O4 core and the macrophage membrane shell, the resulting Fe3O4@MM NPs exhibited good biocompatibility, immune evasion, cancer targeting, and light-to-heat conversion capabilities...
January 15, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29334219/mussel-inspired-conductive-polymer-binder-for-si-alloy-anode-in-lithium-ion-batteries
#2
Hui Zhao, Yang Wei, Cheng Wang, Rui-Min Qiao, Wanli Yang, Phillip B Messersmith, Gao Liu
The excessive volume changes during cell cycling of Si-based anode in lithium ion batteries impeded its application. One major reason for the cell failure is particle isolation during volume shrinkage in delithiation process, which makes strong adhesion between polymer binder and anode active material particles a highly desirable property. Here, a biomimetic side-chain conductive polymer incorporating catechol, a key adhesive component of the mussel holdfast protein, was synthesized. Atomic force microscopy (AFM) based single molecule force measurements of mussel-inspired conductive polymer binder contacting a silica surface revealed similar adhesion toward substrate when compared with an effective Si anode binder, homo-polyacrylic acid (PAA), with the added benefit of being electronically conductive...
January 15, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29333680/cellulose-based-biomimetics-and-their-applications
#3
REVIEW
Ana P C Almeida, João P Canejo, Susete N Fernandes, Coro Echeverria, Pedro L Almeida, Maria H Godinho
Nature has been producing cellulose since long before man walked the surface of the earth. Millions of years of natural design and testing have resulted in cellulose-based structures that are an inspiration for the production of synthetic materials based on cellulose with properties that can mimic natural designs, functions, and properties. Here, five sections describe cellulose-based materials with characteristics that are inspired by gratings that exist on the petals of the plants, structurally colored materials, helical filaments produced by plants, water-responsive materials in plants, and environmental stimuli-responsive tissues found in insects and plants...
January 15, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29333203/biomimetic-microfluidic-platform-for-the-quantification-of-transient-endothelial-monolayer-permeability-and-therapeutic-transport-under-mimicked-cancerous-conditions
#4
Christopher George Uhl, Vladimir R Muzykantov, Yaling Liu
Therapeutic delivery from microvasculature to cancerous sites is influenced by many factors including endothelial permeability, vascular flow rates/pressures, cancer secretion of cytokines and permeabilizing agents, and characteristics of the chosen therapeutics. This work uses bi-layer microfluidics capable of studying dye and therapeutic transport from a simulated vessel to a cancerous region while allowing for direct visualization and quantification of endothelial permeability. 2.5 to 13 times greater dye transport was observed when utilizing small dye sizes (FITC) when compared to larger molecules (FITC-Dextran 4 kDa and FITC-Dextran 70 kDa), respectively...
January 2018: Biomicrofluidics
https://www.readbyqxmd.com/read/29332935/novel-treatment-strategies-for-chronic-kidney-disease-insights-from-the-animal-kingdom
#5
REVIEW
Peter Stenvinkel, Johanna Painer, Makoto Kuro-O, Miguel Lanaspa, Walter Arnold, Thomas Ruf, Paul G Shiels, Richard J Johnson
Many of the >2 million animal species that inhabit Earth have developed survival mechanisms that aid in the prevention of obesity, kidney disease, starvation, dehydration and vascular ageing; however, some animals remain susceptible to these complications. Domestic and captive wild felids, for example, show susceptibility to chronic kidney disease (CKD), potentially linked to the high protein intake of these animals. By contrast, naked mole rats are a model of longevity and are protected from extreme environmental conditions through mechanisms that provide resistance to oxidative stress...
January 15, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29332844/understanding-carbon-nanotube-channel-formation-in-the-lipid-membrane
#6
Moon-Ki Choi, Hyunki Kim, Byung Ho Lee, Teayeop Kim, Junsuk Rho, Moon Ki Kim, Kyunghoon Kim
Carbon nanotube (CNT) has been considered as a prominent nano-channel in cell membranes because of their prominent ion-conductance and ion-selectivity, offering agents for biomimetic channel platform. Using a coarse-grained molecular dynamics simulation, we clarify a construction mechanism of vertical CNT nano-channels in the lipid membrane for a long period, that has been difficult to observe in previous CNT-lipid interaction simulations. The result shows that both lipid coating density and length of CNT affect the suitable fabrication condition for a vertical and stable CNT-channel...
January 15, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29332574/biomacromolecular-based-fibers-in-nanomedicine-a-combination-of-drug-delivery-and-tissue-engineering
#7
Elham Arkan, Abbas Hemati Azandaryani, Pouran Moradipour, Leila Behbood
BACKGROUND: Biopolymers based materials (polysaccharides, lipids, proteins, and nucleic acids) are one of the basic resources in bio-engineering sciences because of desirable features. Moreover, nanobiotechnology innovates nanomaterial and associated technique in nano medicine (drug delivery and tissue engineering). METHODS: In the nano-medicine, fibers are introduced as a successful biomimetic extracellular matrix scaffolds and drug carrier systems. Electrospinning as a simple and cost-effective technique is used to design nanofibers...
January 12, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29331223/structure-based-design-and-application-of-a-nucleotide-coenzyme-mimetic-ligand-application-to-the-affinity-purification-of-nucleotide-dependent-enzymes
#8
Marigianna Marinou, Dimitrios Platis, Farid S Ataya, Evangelia Chronopoulou, Dimitrios Vlachakis, Nikolaos E Labrou
In the present study, a structure-based approach was exploited for the in silico design of a nucleotide coenzyme mimetic ligand. The enzyme formate dehydrogenase (FDH) was employed as a model in our study. The biomimetic ligand was designed and synthesized based on a tryptamine/3-aminopropylphosphonic acid bi-substituted 1,3,5-triazine (Trz) scaffold (Tra-Trz-3APP), which potentially mimics the interactions of NAD+-FDH complex. Molecular docking studies of the biomimetic ligand predicted that it can occupy the same binding site as the natural coenzyme...
January 3, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29330415/unusual-multiscale-mechanics-of-biomimetic-nanoparticle-hydrogels
#9
Yunlong Zhou, Pablo F Damasceno, Bagganahalli S Somashekar, Michael Engel, Falin Tian, Jian Zhu, Rui Huang, Kyle Johnson, Carl McIntyre, Kai Sun, Ming Yang, Peter F Green, Ayyalusamy Ramamoorthy, Sharon C Glotzer, Nicholas A Kotov
Viscoelastic properties are central for gels and other materials. Simultaneously, high storage and loss moduli are difficult to attain due to their contrarian requirements to chemical structure. Biomimetic inorganic nanoparticles offer a promising toolbox for multiscale engineering of gel mechanics, but a conceptual framework for their molecular, nanoscale, mesoscale, and microscale engineering as viscoelastic materials is absent. Here we show nanoparticle gels with simultaneously high storage and loss moduli from CdTe nanoparticles...
January 12, 2018: Nature Communications
https://www.readbyqxmd.com/read/29328519/surface-modification-using-the-biomimetic-method-in-alumina-zirconia-porous-ceramics-obtained-by-the-replica-method
#10
André D R Silva, Willian R Rigoli, Denise Osiro, Daphne C R Mello, Luana M R Vasconcellos, Anderson O Lobo, Eliria M J A Pallone
The modification of biomaterials approved by the Food and Drug Administration could be an alternative to reduce the period of use in humans. Porous bioceramics are widely used as support structures for bone formation and repair. This composite has essential characteristics for an implant, including good mechanical properties, high chemical stability, biocompatibility and adequate aesthetic appearance. Here, three-dimensional porous scaffolds of Al2 O3 containing 5% by volume of ZrO2 were produced by the replica method...
January 12, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29327586/composite-hydrogel-modified-by-igf-1c-domain-improves-stem-cell-therapy-for-limb-ischemia
#11
Xiaomin Wang, Jimin Zhang, Weilong Cui, Yuan Fang, Li Li, Shenglu Ji, Duo Mao, Tingyu Ke, Xin Yao, Dan Ding, Guowei Feng, Deling Kong
Stem cell treatment for critical limb ischemia yields a limited therapeutic effect due to cell loss and dysfunction caused by local ischemic environment. Biomimetic scaffolds emerge as ideal cell delivery vehicles for regulating cell fate via mimicking the components of stem cell niche. Herein, we prepared a bioactive hydrogel by mixing chitosan and hyaluronic acid that is immobilized with C domain peptide of IGF-1 (IGF-1C), and examined whether this hydrogel could augment stem cell survival and therapeutic potential...
January 12, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29327014/design-of-biomimetic-substrates-for-long-term-maintenance-of-alveolar-epithelial-cells
#12
James C H Poon, Zhongfa Liao, Takaya Suzuki, Miranda M Carleton, John P Soleas, J Stewart Aitchison, Golnaz Karoubi, Alison P McGuigan, Thomas K Waddell
There is a need to establish in vitro lung alveolar epithelial culture models to better understand the fundamental biological mechanisms that drive lung diseases. While primary alveolar epithelial cells (AEC) are a useful option to study mature lung biology, they have limited utility in vitro. Cells that survive demonstrate limited proliferative capacity and loss of phenotype over the first 3-5 days in traditional culture conditions. To address this limitation, we generated a novel physiologically relevant cell culture system for enhanced viability and maintenance of phenotype...
January 12, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29324678/immobilization-of-enzymes-on-a-phospholipid-bionically-modified-polysulfone-gradient-pore-membrane-for-the-enhanced-performance-of-enzymatic-membrane-bioreactors
#13
Yizong Guo, Xueyan Zhu, Fei Fang, Xiao Hong, Huimin Wu, Dajing Chen, Xiaojun Huang
Enzymatic membrane bioreactors (EMBRs), with synergistic catalysis-separation performance, have increasingly been used for practical applications. Generally, the membrane properties, particularly the pore structures and interface interactions, have a significant impact on the catalytic efficiency of the EMBR. Therefore, a biomimetic interface based on a phospholipid assembled onto a polysulfone hollow-fiber membrane with perfect radial gradient pores (RGM-PSF) has been prepared in this work to construct a highly efficient and stable EMBR...
January 11, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29323660/laser-doppler-sensing-for-blood-vessel-detection-with-a-biologically-inspired-steerable-needle
#14
Vani Virdyawan, Matthew Oldfield, Ferdinando Rodriguez Y Baena
Puncturing blood vessels during percutaneous intervention in minimally invasive brain surgery can be a life threatening complication. Embedding a forward looking sensor in a rigid needle has been proposed to tackle this problem but, when using a rigid needle, the procedure needs to be interrupted and the needle extracted if a vessel is detected. As an alternative, we propose a novel optical method to detect a vessel in front of a steerable needle. The needle itself is based on a biomimetic, multi-segment design featuring four hollow working channels...
January 11, 2018: Bioinspiration & Biomimetics
https://www.readbyqxmd.com/read/29323433/electrically-driven-microengineered-bioinspired-soft-robots
#15
Su Ryon Shin, Bianca Migliori, Beatrice Miccoli, Yi-Chen Li, Pooria Mostafalu, Jungmok Seo, Serena Mandla, Alessandro Enrico, Silvia Antona, Ram Sabarish, Ting Zheng, Lorenzo Pirrami, Kaizhen Zhang, Yu Shrike Zhang, Kai-Tak Wan, Danilo Demarchi, Mehmet R Dokmeci, Ali Khademhosseini
To create life-like movements, living muscle actuator technologies have borrowed inspiration from biomimetic concepts in developing bioinspired robots. Here, the development of a bioinspired soft robotics system, with integrated self-actuating cardiac muscles on a hierarchically structured scaffold with flexible gold microelectrodes is reported. Inspired by the movement of living organisms, a batoid-fish-shaped substrate is designed and reported, which is composed of two micropatterned hydrogel layers. The first layer is a poly(ethylene glycol) hydrogel substrate, which provides a mechanically stable structure for the robot, followed by a layer of gelatin methacryloyl embedded with carbon nanotubes, which serves as a cell culture substrate, to create the actuation component for the soft body robot...
January 11, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29320700/role-of-phosphorylation-in-moesin-interactions-with-pip2-containing-biomimetic-membranes
#16
Quentin Lubart, Helene Vitet, Fabien Dalonneau, Aline Le Roy, Mathieu Kowalski, Morgane Lourdin, Christine Ebel, Marianne Weidenhaupt, Catherine Picart
Moesin, a protein of the ezrin, radixin, and moesin family, which links the plasma membrane to the cytoskeleton, is involved in multiple physiological and pathological processes, including viral budding and infection. Its interaction with the plasma membrane occurs via a key phosphoinositide, the phosphatidyl(4,5)inositol-bisphosphate (PIP2), and phosphorylation of residue T558, which has been shown to contribute, in cellulo, to a conformationally open protein. We study the impact of a double phosphomimetic mutation of moesin (T235D, T558D), which mimics the phosphorylation state of the protein, on protein/PIP2/microtubule interactions...
January 9, 2018: Biophysical Journal
https://www.readbyqxmd.com/read/29320454/combined-layer-particle-approaches-in-surface-molecular-imprinting-of-proteins-signal-enhancement-and-competition
#17
Nam Van Ho Phan, Hermann F Sussitz, Eva Ladenhauf, Dietmar Pum, Peter A Lieberzeit
Herein we report novel approaches to the molecular imprinting of proteins utilizing templates sizing around 10 nm and some 100 nm. The first step comprised synthesizing nanoparticles of molecularly imprinted polymers (MIP) towards bovine serum albumin (BSA) and characterizing them according to size and binding capacity. In a second step, they were utilized as templates. Quartz crystal microbalances (QCM) coated with MIP thin films based on BSA MIP nanoparticles lead to a two-fold increase in sensor responses, compared with the case of directly using the protein as the template...
January 10, 2018: Sensors
https://www.readbyqxmd.com/read/29319533/flax-stems-from-a-specific-architecture-to-an-instructive-model-for-bioinspired-composite-structures
#18
Christophe Baley, Camille Goudenhooft, Marianne Gibaud, Alain Bourmaud
The present paper proposes to carefully study and describe the reinforcement mechanisms within a flax stem, which is an exceptional natural model of composite structure. Thanks to accurate microscopic investigations, with both optical and SEM method, we finely depicted the flax stem architecture, which can be view as a composite structure with an outer protection, a unidirectional ply on the periphery and a porous core; each component has a specific function, such as mechanical reinforcement for the unidirectional ply and the porous core...
January 10, 2018: Bioinspiration & Biomimetics
https://www.readbyqxmd.com/read/29318880/bismuth-oxyiodide-couples-with-glucose-oxidase-a-special-synergized-dual-catalysis-mechanism-for-photoelectrochemical-enzymatic-bioanalysis
#19
Ling Zhang, Yi-Fan Ruan, Yan Yu Liang, Wei-Wei Zhao, Xiao-Dong Yu, Jing-Juan Xu, Hong-Yuan Chen
On the basis of a special synergized dual-catalysis mechanism, this work reports the preparation of BiOI-based heterojunction and its use for cathodic photoelectrochemical (PEC) oxidase biosensing, which, unexpectedly, revealed that H2O2 impacted greater than O2. Specifically, BiOI layer was in situ formed on the substrate through an impregnating hydroxylation method for the following coupling with the model enzyme of glucose oxidases (GOx). The constructed cathodic PEC enzyme sensor exhibited good analytical performance of rapid response, high stability, and good selectivity...
January 10, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29318678/nociceptive-memristor
#20
Yumin Kim, Young Jae Kwon, Dae Eun Kwon, Kyung Jean Yoon, Jung Ho Yoon, Sijung Yoo, Hae Jin Kim, Tae Hyung Park, Jin-Woo Han, Kyung Min Kim, Cheol Seong Hwang
The biomimetic characteristics of the memristor as an electronic synapse and neuron have inspired the advent of new information technology in the neuromorphic computing. The application of the memristors can be extended to the artificial nerves on condition of the presence of electronic receptors which can transfer the external stimuli to the internal nerve system. In this work, nociceptor behaviors are demonstrated from the Pt/HfO2 /TiN memristor for the electronic receptors. The device shows four specific nociceptive behaviors; threshold, relaxation, allodynia, and hyperalgesia, according to the strength, duration, and repetition rate of the external stimuli...
January 10, 2018: Advanced Materials
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