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https://www.readbyqxmd.com/read/28930451/a-biomimetic-stress-sensitive-hydrogel-controlled-by-dna-nanoswitches
#1
Swapneel R Deshpande, Roel Hammink, Frank H T Nelissen, Alan E Rowan, Hans A Heus
One of the most intriguing and important aspects of biological supramolecular materials is its ability to adapt macroscopic properties in response to environmental cues for controlling cellular processes. Recently, bulk matrix stiffness, in particular stress sensitivity, has been established as a key mechanical cue in cellular function and development. However, stress-stiffening capacity and the ability to control and exploit this key characteristic is relatively new to the field of biomimetic materials. In this work, DNA-responsive hydrogels, composed of semiflexible PIC polymers equipped with DNA cross-linkers, were engineered to create mimics of natural biopolymer networks that capture these essential elastic properties and can be controlled by external stimuli...
September 20, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28930438/supported-planar-mammalian-membranes-as-models-of-in-vivo-cell-surface-architectures
#2
Han-Yuan Liu, Hannah Grant, Hung-Lun Hsu, Raya Sorkin, Filip Bošković, G J L Wuite, Susan Daniel
Emerging technologies use cell plasma membrane vesicles or 'blebs' as an intermediate to form molecularly complete, planar cell surface mimetics that are compatible with a variety of characterization tools and microscopy methods. This approach enables direct incorporation of membrane proteins into supported lipid bilayers without using detergents and reconstitution and preserves native lipids and membrane species. Such a system can be advantageous as in vitro models of in vivo cell surfaces for study of the roles of membrane proteins as drug targets in drug delivery, host-pathogen interactions, tissue engineering, and many other bioanalytical and sensing applications...
September 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28930358/fabrication-and-characterization-of-a-3d-bioprinted-nanoparticle-hydrogel-hybrid-device-for-biomimetic-detoxification
#3
Maggie S Chen, Yue Zhang, Liangfang Zhang
A biomimetic micro/nanodevice is 3D bioprinted using polyethylene glycol (PEG) hydrogel as the supporting platform, along with the red blood cell (RBC) membrane-coated nanoparticles (RBC-NPs) encapsulated in the hydrogel as the detoxification mechanism. RBC-NPs are prepared through a nanoprecipitation and coating method and then mixed into the poly(ethylene glycol) diacrylate (PEGDA) monomer solution for 3D bioprinting through photopolymerization. This resulting detoxification device is engineered with multiple inner channels for the RBC-NPs to nonspecifically soak up the various toxins flowing through the channels...
September 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28930090/biomimetic-matrix-fabricated-by-lmp-1-gene-transduced-mc3t3-e1-cells-for-bone-regeneration
#4
Junxuan Ma, Wei Guo, Manman Gao, Baoding Huang, Qihua Qi, Zemin Ling, Yan Chen, Hao Hu, Hailian Zhou, Fei Yu, Ke Chen, Zhiyu Zhou, Deming Xiao, Xuenong Zou
Bone healing is regulated by multiple microenvironmental signals provided by the extracellular matrix (ECM). The study aimed to mimic native osteoinductive microenvironment by developing an ECM using gene-transduced cells. LIM mineralization protein-1 (LMP-1) gene was transferred to the murine pre-osteoblast cells (MC3T3-E1) using lentiviral vectors. Western blotting essay indicated that the MC3T3-E1 cells expressed an increased level of bone morphologic protein-2, -4 and-7 (BMP-2, -4 and -7) after LMP-1 gene transduction...
September 20, 2017: Biofabrication
https://www.readbyqxmd.com/read/28929590/enhancing-photocurrent-generation-in-photosynthetic-reaction-center-based-photoelectrochemical-cells-with-biomimetic-dna-antenna
#5
Anne-Marie Carey, Haojie Zhang, Minghui Liu, Daiana Sharaf, Natalie Akram, Hao Yan, Su Lin, Neal Woodbury, Dong-Kyun Seo
3 to 4 times higher performance of biohybrid photoelectrochemical cells with photosynthetic reaction centers (RC) has been achieved by using a DNA-based biomimetic antenna. Synthetic dyes Cy3 and Cy5 were chosen and strategically placed in the anntena in such a way that they can collect additional light energy in the visible region of the solar spectrum and transfer it to RC through Förster resonance energy transfer (FRET). The antenna, a DNA templated multiple dye system, is attached to each Rhodobacter sphaeroides RC near the primary donor, P, to facilitate the energy transfer process...
September 19, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28929134/cooperative-deformations-of-periodically-patterned-hydrogels
#6
Zhi Jian Wang, Chao Nan Zhu, Wei Hong, Zi Liang Wu, Qiang Zheng
Nature has shown elegant paradigms of smart deformation, which inspired biomimetic systems with controllable bending, folding, and twisting that are significant for the development of soft electronics and actuators. Complex deformations are usually realized by additively incorporating typical structures in selective domains with little interaction. We demonstrate the cooperative deformations of periodically patterned hydrogel sheets, in which neighboring domains mutually interact and cooperatively deform. Nonswelling disc gels are periodically positioned in a high-swelling gel...
September 2017: Science Advances
https://www.readbyqxmd.com/read/28928478/biomimetically-engineered-amphotericin-b-nano-aggregates-circumvent-toxicity-constraints-and-treat-systemic-fungal-infection-in-experimental-animals
#7
Qamar Zia, Owais Mohammad, Mohd Ahmar Rauf, Wasi Khan, Swaleha Zubair
Biomimetic synthesis of nanoparticles offers a convenient and bio friendly approach to fabricate complex structures with sub-nanometer precision from simple precursor components. In the present study, we have synthesized nanoparticles of Amphotericin B (AmB), a potent antifungal agent, using Aloe vera leaf extract. The synthesis of AmB nano-assemblies (AmB-NAs) was established employing spectro-photometric and electron microscopic studies, while their crystalline nature was established by X-ray diffraction...
September 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28928362/analysis-of-the-pressure-requirements-for-silk-spinning-reveals-a-pultrusion-dominated-process
#8
James Sparkes, Chris Holland
Silks are remarkable materials with desirable mechanical properties, yet the fine details of natural production remain elusive and subsequently inaccessible to biomimetic strategies. Improved knowledge of the natural processes could therefore unlock development of a host of bio inspired fibre spinning systems. Here, we use the Chinese silkworm Bombyx mori to review the pressure requirements for natural spinning and discuss the limits of a biological extrusion domain. This provides a target for finite element analysis of the flow of silk proteins, with the aim of bringing the simulated and natural domains into closer alignment...
September 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/28927931/polyurethane-foam-scaffold-as-in-vitro-model-for-breast-cancer-bone-metastasis
#9
Valentina Angeloni, Nicola Contessi, Cinzia De Marco, Serena Bertoldi, Maria Cristina Tanzi, Maria Grazia Daidone, Silvia Farè
Breast cancer (BC) represents the most incident cancer case in women (29%), with high mortality rate. Bone metastasis occurs in 20-50% cases and, despite advances in BC research, the interactions between tumor cells and the metastatic microenvironment are still poorly understood. In vitro 3D models gained great interest in cancer research, thanks to the reproducibility, the 3D spatial cues and associated low costs, compared to in vivo and 2D in vitro models. In this study, we investigated the suitability of a poly-ether-urethane (PU) foam as 3D in vitro model to study the interactions between BC tumor-initiating cells and the bone microenvironment...
September 16, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28927342/expert-opinion-biomimetic-functionalized-surfaces-and-the-induction-of-bone-formation
#10
Ugo Ripamonti
Tissue engineering still needs to assign the molecular basis of pattern formation, tissue induction and morphogenesis: What next to morphogens and stem cells? Macroporous biomimetic matrices per se, without the addition of the soluble osteogenic molecular signals of the transforming growth factor-β (TGF-β) supergene family, initiate the induction of bone formation. Carving geometries within different calcium phosphate-based macroporous bioreactors we show that geometric cues imprinted within the macroporous spaces initiate the spontaneous induction of bone...
September 19, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28925549/biomaterial-substrate-mediated-multicellular-spheroid-formation-and-their-applications-in-tissue-engineering
#11
REVIEW
Ting-Chen Tseng, Chui-Wei Wong, Fu-Yu Hsieh, Shan-Hui Hsu
Three-dimentional (3D) multicellular aggregates (spheroids), compared to the traditional 2D monolayer cultured cells, are physiologically more similar to the cells in vivo. So far there are various techniques to generate 3D spheroids. Spheroids obtained from different methods have already been applied to regenerative medicine or cancer research. Among the cell spheroids created by different methods, the substrate-derived spheroids and their forming mechanism are unique. This review focuses on the formation of biomaterial substrate-mediated multicellular spheroids and their applications in tissue engineering and tumor models...
September 19, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/28923362/human-retinal-endothelial-cells-and-astrocytes-cultured-on-3-d-scaffolds-for-ocular-drug-discovery-and-development
#12
Kay D Beharry, Charles L Cai, Gloria B Valencia, Douglas Lazzaro, Arwin M Valencia, Fabrizio Salomone, Jacob V Aranda
Topical ocular ketorolac improves the outcomes of severe retinopathy of prematurity and when administered with systemic caffeine, decreases the severity of oxygen-induced retinopathy. We tested the hypothesis that co-cultures of human retinal endothelial cells (HRECs) and human retinal astrocytes (HRAs) on 3-dimensional (3-D) hydrogel scaffolds is a more representative biomimetic paradigm of the blood-retinal-barrier (BRB) than 2-D cultures, and should be utilized for preclinical drug discovery and development...
September 15, 2017: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/28922634/functionalisation-of-ti6al4v-and-hydroxyapatite-surfaces-with-combined-peptides-based-on-kklpda-and-eeeeeeee-peptides
#13
Gabriela Melo Rodriguez, James Bowen, David Grossin, Besim Ben-Nissan, Artemis Stamboulis
Surface modifications are usually performed on titanium alloys to improve osteo-integration and surface bioactivity. Modifications such as alkaline and acid etching, or coating with bioactive materials such as hydroxyapatite, have previously been demonstrated. The aim of this work is to develop a peptide with combined titanium oxide and hydroxyapatite binders in order to achieve a biomimetic hydroxyapatite coating on titanium surfaces. The technology would also be applicable for the functionalisation of titanium and hydroxyapatite surfaces for selective protein adsorption, conjugation of antimicrobial peptides, and adsorption of specialised drugs for drug delivery...
September 9, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28921946/biomimetic-magnetosomes-as-versatile-artificial-antigen-presenting-cells-to-potentiate-t-cell-based-anticancer-therapy
#14
Qianmei Zhang, Wei Wei, Peilin Wang, Liping Zuo, Feng Li, Jin Xu, Xiaobo Xi, Xiaoyong Gao, Guanghui Ma, Hai-Yan Xie
Adoptive T-cell transfer for cancer therapy relies on both effective ex vivo T-cell expansion and in vivo targeting performance. One promising but challenging method for accomplishing this purpose is to construct multifunctional artificial antigen-presenting cells (aAPCs). We herein developed biomimetic magnetosomes as versatile aAPCs, wherein magnetic nanoclusters were coated with azide-engineered leucocyte membranes and then decorated with T-cell stimuli through copper-free click chemistry. These nano aAPCs not only exhibited high performance for antigen-specific cytotoxic T-cell (CTL) expansion and stimulation but also visually and effectively guided reinfused CTLs to tumor tissues through magnetic resonance imaging and magnetic control...
September 20, 2017: ACS Nano
https://www.readbyqxmd.com/read/28921943/self-assembly-of-mesoscale-artificial-clathrin-mimics
#15
Yifan Kong, Mina-Elraheb S Hanna, Denys Zhuo, Katherine G Chang, Tara Bozorg-Grayeli, Nicholas A Melosh
Fluidic control and sampling in complex environments is an important process in biotechnology, materials synthesis, and microfluidics. An elegant solution to this problem has evolved in nature through cellular endocytosis, where the dynamic recruitment, self-assembly, and spherical budding of clathrin proteins allows cells to sample their external environment. Yet despite the importance and utility of endocytosis, artificial systems which can replicate this dynamic behavior have not been developed. Guided by clathrin's unusual structure, we created simplified metallic microparticles that capture the three-legged shape, particle curvature, and interfacial attachment characteristics of clathrin...
September 18, 2017: ACS Nano
https://www.readbyqxmd.com/read/28920612/visible-light-mediated-oxidative-demethylation-of-n-6-methyl-adenines
#16
Li-Jun Xie, Rui-Li Wang, Dong Wang, Li Liu, Liang Cheng
We report a simple protocol that affords oxidative demethylation of N(6)-methyl groups in N(6)-methyl adenines (m(6)A). The biologically compatible photocatalyst riboflavin prompts a highly selective C-H abstraction from N(6)-methyl in adenines under the irradiation of a visible blue LED light, affording a novel and highly selective biomimetic demethylation of m(6)A and related N-methyl adenine analogues.
September 18, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28920442/novelty-of-dynamic-process-in-the-synthesis-of-biocompatible-silica-nanotubes-by-biomimetic-glycyldodecylamide-as-a-soft-template
#17
Hyejung Choi, Joong-Jo Kim, Yong-Hwan Mo, Benjaram Mahipal Reddy
Dynamic process in the synthesis of silica nanotubes (SNTs) by utilizing glycyldodecylamide (GDA) as a soft template was thoroughly investigated. The morphological evolution from GDA to SNTs was deeply explored to elucidate the formation mechanism for optimizing the synthesis procedure. Various analytical tools, namely, XRD, FTIR, SEM, TEM, Z-potential, and N2 adsorption/desorption isotherms were employed during the synthesis procedure. The interactive structure of GDA was also investigated using TEM-EDX as a function of aging time...
September 18, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28919736/carbon-nanotubes-gathered-onto-silica-particles-lose-their-biomimetic-properties-with-the-cytoskeleton-becoming-biocompatible
#18
Elena González-Domínguez, Nerea Iturrioz-Rodríguez, Esperanza Padín-González, Juan Villegas, Lorena García-Hevia, Moisés Pérez-Lorenzo, Wolfgang J Parak, Miguel A Correa-Duarte, Mónica L Fanarraga
Carbon nanotubes (CNTs) are likely to transform the therapeutic and diagnostic fields in biomedicine during the coming years. However, the fragmented vision of their side effects and toxicity in humans has proscribed their use as nanomedicines. Most studies agree that biocompatibility depends on the state of aggregation/dispersion of CNTs under physiological conditions, but conclusions are confusing so far. This study designs an experimental setup to investigate the cytotoxic effect of individualized multiwalled CNTs compared to that of identical nanotubes assembled on submicrometric structures...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28915048/xfel-radiation-damage-through-the-s-state-cycle-of-the-oxygen-evolving-complex-of-photosystem-ii
#19
Muhamed Amin, Mikhail Askerka, Victor S Batista, Gary W Brudvig, Marilyn R Gunner
The oxygen-evolving complex (OEC) of photosystem II (PSII) catalyzes water-splitting through a reaction mechanism that cycles the OEC through five redox states, the 'S-state' intermediates. Understanding structure/function relations of the S-state intermediates is crucial for elucidation of the reaction mechanism and the design of biomimetic catalytic systems. Due to the limitations of conventional X-ray crystallography, serial femtosecond X-ray crystallography has been used to minimize the radiation-damage...
September 15, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28914740/the-role-of-precisely-matching-fascicles-in-the-quick-recovery-of-nerve-function-in-long-peripheral-nerve-defects
#20
Liwei Yan, Zhi Yao, Tao Lin, Qingtang Zhu, Jian Qi, Liqiang Gu, Jintao Fang, Xiang Zhou, Xiaolin Liu
Peripheral nerve injury therapy in the clinic remains less than satisfactory. The gold standard of treatment for long peripheral nerve defects is autologous nerve grafts; however, numerous clinical complications are associated with this treatment. As tissue engineering has developed, tissue-engineered nerve grafts (TENGs) have shown potential applications as alternatives to autologous nerve grafts. To verify the important role of the biomimetic pathway of fascicle design in TENGs, we designed an animal model to study the role of the precise matching of fascicles in the effectiveness of nerve function recovery...
October 18, 2017: Neuroreport
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