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https://www.readbyqxmd.com/read/28816441/an-integrated-design-material-and-fabrication-platform-for-engineering-biomechanically-and-biologically-functional-soft-tissues
#1
Onur Bas, Davide D'Angella, Jeremy G Baldwin, Nathan J Castro, Felix M Wunner, Navid T Saidy, Stefan Kollmannsberger, Alessandro Reali, Ernst Rank, Elena M De-Juan-Pardo, Dietmar W Hutmacher
We present a design rationale for stretchable soft network composites for engineering tissues which predominantly function under high tensile loads. The convergence of 3D-printed fibers selected from a design library and biodegradable interpenetrating polymer networks (IPNs) result in biomimetic tissue engineered constructs (bTECs) with fully tunable properties that can match specific tissue requirements. We present our technology platform using an exemplary soft network composite model that is characterized to be flexible, yet ~125 times stronger (E = 3...
August 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28816316/hydrogel-scaffolds-for-differentiation-of-adipose-derived-stem-cells
#2
REVIEW
Qiutong Huang, Yijie Zou, Maria C Arno, Shuai Chen, Tao Wang, Jingyi Gao, Andrew P Dove, Jianzhong Du
Natural extracellular matrices (ECMs) have been widely used as a support for the adhesion, migration, differentiation, and proliferation of adipose-derived stem cells (ADSCs). However, poor mechanical behavior and unpredictable biodegradation properties of natural ECMs considerably limit their potential for bioapplications and raise the need for different, synthetic scaffolds. Hydrogels are regarded as the most promising alternative materials as a consequence of their excellent swelling properties and their resemblance to soft tissues...
August 17, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28816035/surface-modification-with-ecm-inspired-sdf-1%C3%AE-laminin-loaded-nanocoating-for-vascular-wound-healing
#3
Tao Liu, Xin Wang, Xiaohan Tang, Tao Gong, Wei Ye, Changjiang Pan, Hongyan Ding, Xun Luo, Xia Li, Qing Mei Wang
Surface biomimetic modification with extra-cellular matrix (ECM)-derived biomolecules is an emerging potential method of accelerating the healing of vascular stent lesions. However, insufficient capacity of the constructed biofunctional layer in maintaining its long-term efficiency and preventing thrombus and neointimal hyperplasia continue to be major limitations in clinical application. Based on the structure and function of ECM, in this study, we constructed a novel stromal cell-derived factor-1α (SDF-1α)/laminin-loaded nanocoating on the 316L stainless steel (SS) surface to provide improved function in modulation of vascular remodeling...
August 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28814127/carbon-nanotubes-functionalized-with-folic-acid-attached-via-biomimetic-peptide-linker
#4
Justyna Fraczyk, Malgorzata Walczak, Lukasz Szymanski, Zbigniew Kolacinski, Henryk Wrzosek, Ireneusz Majsterek, Karolina Przybylowska-Sygut, Zbigniew J Kaminski
AIM: Anchoring folic acid (FA) with a biomimetic peptidic linker resistant to proteolytic degradation to act as a homing device on functionalized carbon nanotubes. MATERIALS & METHODS: Ethylenediamine was attached to oxidized multiwalled carbon nanotubes (MWNTs) using 4-(4,6-dimethoxy-[1,3,5]triazin-2-yl)-4-methylmorpholinium tetrafluoroborate. FA was coupled with 6-aminohexanoic acid and derivatives of β-alanine, affording four intermediates, which connected to the MWNTs via peptidic linkers of various lengths...
August 17, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28814019/stiffness-control-of-a-nylon-twisted-coiled-actuator-for-use-in-mechatronic-rehabilitation-devices
#5
Brandon P R Edmonds, Ana Luisa Trejos
Mechatronic rehabilitation devices, especially wearables, have been researched extensively and proven to be promising additions to physical therapy, but most designs utilize traditional actuators providing unnatural, robot-like movements. Therefore, many researchers have focused on the development of actuators that mimic biological properties to provide patients with improved results, safety, and comfort. Recently, a twisted-coiled actuator (TCA) made from nylon thread has been found to possess many of these important properties when heated, such as variable stiffness, flexibility, and high power density...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28814004/biomimetic-finger-extension-mechanism-for-soft-wearable-hand-rehabilitation-devices
#6
Dong Hyun Kim, Si-Hwan Heo, Hyung-Soon Park
For the rehabilitation and assistance of the hand functions, wearable devices have been developed, and the interest in tendon driven mechanisms have especially increased since it allows light weight and compact design. The tendon driven hand rehabilitation devices provides grasping force via exo-tendons routed on the dorsal and palmar sides of the hand pulled by remotely located actuators. However, most of the devices were not able to provide natural joint extension sequence of the finger and showed hyperextension of finger joints because the tendons for extension were fixed at the fingertip, concentrating the torque at the distal interphalangeal joint...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813991/voluntary-phantom-hand-and-finger-movements-in-transhumerai-amputees-could-be-used-to-naturally-control-polydigital-prostheses
#7
Nathanael Jarrasse, Caroline Nicol, Florian Richer, Amelie Touillet, Noel Martinet, Jean Paysant, Jozina B De Graaf
An arm amputation is extremely invalidating since many of our daily tasks require bi-manual and precise control of hand movements. Perfect hand prostheses should therefore offer a natural, intuitive and cognitively simple control over their numerous biomimetic active degrees of freedom. While efficient polydigital prostheses are commercially available, their control remains complex to master and offers limited possibilities, especially for high amputation levels. In this pilot study, we demonstrate the possibility for upper-arm amputees to intuitively control a polydigital hand prosthesis by using surface myoelectric activities of residual limb muscles (sEMG) associated with phantom limb movements, even if these residual arm muscles on which the phantom activity is measured were not naturally associated with hand movements before amputation...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813979/towards-low-back-support-with-a-passive-biomimetic-exo-spine
#8
Matthias B Naf, Laura De Rijcke, Carlos Rodriguez Guerrero, Matthew Millard, Bram Vanderborght, Dirk Lefeber
Low-Back Pain (LBP) affects a large portion of the working population. Preventive exoskeletons have been proposed to reduce the moments on the lower back, specifically around the lumbosacral (L5/S1) joint. High correlation has been shown, between reducing the moments around the L5/S1 joint and intervertebral compression forces, which in turn have been identified as a risk factor for developing LBP. However, most passive back support exoskeletons use rigid plates or stiff beams to support the spine that limit the range of motion of the wearer...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28812999/synthesis-and-evaluation-of-a-sodium-alginate-4-aminosalicylic-acid-based-microporous-hydrogel-for-potential-viscosupplementation-for-joint-injuries-and-arthritis-induced-conditions
#9
Dharmesh R Chejara, Mostafa Mabrouk, Pradeep Kumar, Yahya E Choonara, Pierre P D Kondiah, Ravindra V Badhe, Lisa C du Toit, Divya Bijukumar, Viness Pillay
A microporous hydrogel was developed using sodium alginate (alg) and 4-aminosalicylic acid (4-ASA). The synthesized hydrogel was characterized using various analytical techniques such as Fourier transform infrared spectroscopy (FTIR), Carbon-13 nuclear magnetic resonance ((13)C-NMR), X-ray powder diffraction (XRD), scanning electron microscopy (SEM), and differential scanning calorimetry (DSC). Additonal carboxyl and hydroxyl functional groups of 4-ASA provided significant lubrication and stress-triggered sol-gel transition to the conjugated hydrogel...
August 16, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28811739/a-fem-experimental-approach-for-the-development-of-a-conceptual-linear-actuator-based-on-tendril-s-free-coiling
#10
Luca Cortese, Selena Milanovic, Renato Vidoni
Within the vastness of the plant species, certain living systems show tendril structures whose motion is of particular interest for biomimetic engineers. Tendrils sense and coil around suitable grips, and by shortening in length, they erect the remaining plant body. To achieve contraction, tendrils rotate along their main axis and shift from a linear to a double-spring geometry. This phenomenon is denoted as the free-coiling phase. In this work, with the aim of understanding the fundamentals of the mechanics behind the free coiling, a reverse-engineering approach based on the finite element method was firstly applied...
2017: Applied Bionics and Biomechanics
https://www.readbyqxmd.com/read/28811463/a-light-regulated-host-guest-based-nanochannel-system-inspired-by-channelrhodopsins-protein
#11
Yue Sun, Junkai Ma, Fan Zhang, Fei Zhu, Yuxiao Mei, Lu Liu, Demei Tian, Haibing Li
The light-controlled gating of ion transport across membranes is central to nature (e.g., in protein channels). Herein, inspired by channelrhodopsins, we introduce a facile non-covalent approach towards light-responsive biomimetic channelrhodopsin nanochannels using host-guest interactions between a negative pillararene host and a positive azobenzene guest. By switching between threading and dethreading states with alternating visible and UV light irradiation, the functional channels can be flexible to regulate the inner surface charge of the channels, which in turn was exploited to achieve different forms of ion transport, for instance, cation-selective transport and anion-selective transport...
August 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/28809430/a-one-step-method-for-the-functional-and-property-modification-of-dopa-based-nanocoatings
#12
Qinghua Lyu, Jieyu Zhang, Koon Gee Neoh, Christina Li Lin Chai
Biomimetic poly(catecholamine) coatings have gained much attention in recent years due to their versatility as functional materials. Despite this, only limited methods are available to modify the function and property of poly(catecholamine) coatings, primarily through post-modification methods. Our approach reported herein provides a simple approach to the fabrication of novel functionalized poly(catecholamine) coatings. The strategy employs the copolymerization of N-Ac-3,4-dihydroxyphenylalanine methyl ester (NADOPAMe) with nucleophilic additives, giving rise to nano-coatings on various surfaces including plastic, metal, glass and polymers...
August 15, 2017: Nanoscale
https://www.readbyqxmd.com/read/28809073/biocatalytic-stimuli-responsive-asymmetric-triblock-terpolymer-membranes-for-localized-permeability-gating
#13
Jennifer L Poole, Scott Donahue, David Wilson, Yuk Mun Li, Qi Zhang, Yibei Gu, Rachel Ferebee, Zhao Lu, Rachel Mika Dorin, Lawrence F Hancock, Larry Takiff, Ilhem F Hakem, Michael R Bockstaller, Ulrich Wiesner, Jeremy Walker
The functionalization with phosphotriesterase of poly(isoprene-b-styrene-b-4-vinylpyridine)-based nanoporous membranes fabricated by self-assembly and nonsolvent induced phase separation (SNIPS) is shown to enable dynamically responsive membranes capable of substrate-specific and localized gating response. Integration of the SNIPS process with macroporous nylon support layers yields mechanically robust textile-type films with high moisture vapor transport rates that display rapid and local order-of-magnitude modulation of permeability...
August 15, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28808430/amelogenin-affects-brushite-crystal-morphology-and-promotes-its-phase-transformation-to-monetite
#14
Dongni Ren, Qichao Ruan, Jinhui Tao, Jonathan Lo, Steven Nutt, Janet Moradian-Oldak
Amelogenin protein is involved in organized apatite crystallization during enamel formation. Brushite (CaHPO4·2H2O), one of the precursors of hydroxyapatite mineralization in vitro, has been used for fabrication of biomaterials for hard tissue repair. In order to explore its potential application in biomimetic material synthesis, we studied the influence of the enamel protein amelogenin on brushite morphology and phase transformation to monetite. Our results show that amelogenin can adsorb onto the surface of brushite, leading to the formation of layered morphology on the (010) face...
September 7, 2016: Crystal Growth & Design
https://www.readbyqxmd.com/read/28805830/in-vitro-and-in-vivo-analysis-of-visible-light-crosslinkable-gelatin-methacryloyl-gelma-hydrogels
#15
Iman Noshadi, Seonki Hong, Kelly E Sullivan, Ehsan Shirzaei Sani, Roberto Portillo-Lara, Ali Tamayol, Su Ryon Shin, Albert E Gao, Whitney L Stoppel, Lauren D Black Iii, Ali Khademhosseini, Nasim Annabi
Photocrosslinkable materials have been frequently used for constructing soft and biomimetic hydrogels for tissue engineering. Although ultraviolet (UV) light is commonly used for photocrosslinking such materials, its use has been associated with several biosafety concerns such as DNA damage, accelerated aging of tissues, and cancer. Here we report an injectable visible light crosslinked gelatin-based hydrogel for myocardium regeneration. Mechanical characterization revealed that the compressive moduli of the engineered hydrogels could be tuned in the range of 5-56 kPa by changing the concentrations of the initiator, co-initiator and co-monomer in the precursor formulation...
August 14, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28803478/biomimetic-bone-like-hydroxyapatite-by-mineralization-on-supramolecular-porous-fiber-networks
#16
Bo Li, Lei Kan, Xinyue Zhang, Jie Li, Ruiting Li, Qinyuan Gui, Dengli Qiu, Fei He, Ning Ma, Yapei Wang, Hao Wei
Hydroxyapatite (HA), the main inorganic component of bone tissue, is mineralized with collagen fibril scaffolds during bone formation. Inspired by the process, a self-assembled porous network architecture was designed and synthesized by using the 2-ureido-4[1H]-pyrimidone (UPy) modified glycerol molecule UPy-Gly, which was further utilized as a template for biomimetic mineralization. When incubated in simulated body fluid (SBF), the HA nucleus first formed in the holes of the template by the induction of hydroxyls on the surface, grew along the nanofibers, and fused with the template to fabricate hydroxyapatite composites (UPy-Gly/HA)...
August 18, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28802201/biomimetic-surfaces-supporting-dissociated-pancreatic-islet-cultures
#17
Parker L Andersen, Patrick Vermette
This study describes a method to screen biomimetic surfaces based on intracellular insulin content of either fully or partly dissociated primary endocrine islet tissue. It is challenging to maintain endocrine pancreatic islets and more so, dissociated ones. Physiological activity of isolated islet cells in vitro declines due to loss of cell-to-cell and cell-to-extracellular matrix interactions. An in vitro model was developed to evaluate specific extracellular binding components potentially affecting islet biology, with the intention to identify in vivo-like peptides promoting survival and function...
July 25, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28801269/elastin-plga-hybrid-electrospun-nanofiber-scaffolds-for-salivary-epithelial-cell-self-organization-and-polarization
#18
Zahraa I Foraida, Tim Kamaldinov, Deirdre A Nelson, Melinda Larsen, James Castracane
Development of electrospun nanofibers that mimic the structural, mechanical and biochemical properties of natural extracellular matrices (ECMs) is a promising approach for tissue regeneration. Electrospun fibers of synthetic polymers partially mimic the topography of the ECM, however, their high stiffness, poor hydrophilicity and lack of in vivo-like biochemical cues is not optimal for epithelial cell self-organization and function. In search of a biomimetic scaffold for salivary gland tissue regeneration, we investigated the potential of elastin, an ECM protein, to generate elastin hybrid nanofibers that have favorable physical and biochemical properties for regeneration of the salivary glands...
August 8, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28800466/monitoring-and-modulating-ion-traffic-in-hybrid-lipid-polymer-vesicles
#19
Walter F Paxton, Patrick T McAninch, Komandoor E Achyuthan, Sun Hae Ra Shin, Haley L Monteith
Controlling the traffic of molecules and ions across membranes is a critical feature in a number of biologically relevant processes and highly desirable for the development of technologies based on membrane materials. In this paper, ion transport behavior of hybrid lipid/polymer membranes was studied in the absence and presence of ion transfer agents. A pH-sensitive fluorophore was used to investigate ion (H(+)/OH(-)) permeability across hybrid lipid/polymer membranes as a function of the fraction of amphiphilic block copolymer...
August 1, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28800434/enhanced-photothermal-therapy-of-biomimetic-polypyrrole-nanoparticles-through-improving-blood-flow-perfusion
#20
Xuejun Wang, Haichun Li, Xianping Liu, Ye Tian, Huishu Guo, Ting Jiang, Zimiao Luo, Kai Jin, Xinping Kuai, Yao Liu, Zhiqing Pang, Wuli Yang, Shun Shen
In this study, we reported a strategy to improve delivery efficiency of a long-circulation biomimetic photothermal nanoagent for enhanced photothermal therapy through selectively dilating tumor vasculature. By using a simply nanocoating technology, a biomimetic layer of natural red blood cell (RBC) membranes was camouflaged on the surface of photothermal polypyrrole nanoparticles (PPy@RBC NPs). The erythrocyte-mimicking PPy NPs inherited the immune evasion ability from natural RBC resulting in superior prolonged blood retention time...
August 5, 2017: Biomaterials
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