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https://www.readbyqxmd.com/read/28319669/cell-adhesion-on-dynamic-supramolecular-surfaces-probed-by-fluid-force-microscopy-based-single-cell-force-spectroscopy
#1
Shrikrishnan Sankaran, Leena Jaatinen, Jenny Brinkmann, Tomaso Zambelli, Janos Vörös, Pascal Jonkheijm
Biomimetic and stimuli-responsive cell-material interfaces are actively being developed to study and control various cell-dynamics phenomena. Since cells naturally reside in the highly dynamic and complex environment of the extracellular matrix, attempts are being made to replicate these conditions in synthetic biomaterials. Supramolecular chemistry, dealing with non-covalent interactions, has recently provided possibilities to incorporate such dynamicity and responsiveness in various types of architectures...
March 20, 2017: ACS Nano
https://www.readbyqxmd.com/read/28318155/-biomineralization-of-electrospun-polycaprolactone-guided-bone-regeneration-membrane
#2
Deng Xia, Bai Shi
OBJECTIVE: To evaluate the biomineralization of the tissue-engineering electrospun polycaprolactone (PCL) scaffold and its potential use for guided bone regeneration (GBR) membranes. METHODS: PCL ultrafinefiber scaffolds were fabricated by electrospinning and then immersed in supersaturated calcification solution (SCS) for biomineralization investigation. The electrospun PCL scaffolds and the calcium phosphate coating were identified by scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR)...
December 1, 2016: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28317772/ultrasensitive-detection-of-clenbuterol-by-a-covalent-imprinted-polymer-as-a-biomimetic-antibody
#3
Yiwei Tang, Jingwen Gao, Xiuying Liu, Xue Gao, Tao Ma, Xiaonan Lu, Jianrong Li
As an ideal biomimetic antibody, molecularly imprinted polymer (MIP) has shown great promise in immunoassays. Here, we developed a covalent imprinting method to prepare MIP artificial antibody towards clenbuterol on the well surface of a microtiter plate. Template molecule (clenbuterol) was splited by hydrolysis with functional monomer and removed by methanol/acetic acid solution, and then three-dimensional cavities were fabricated in the MIP, which can rebind template molecule via hydrogen bond interaction...
August 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28317269/hyper-assembly-of-self-assembled-glycoclusters-mediated-by-specific-carbohydrate-carbohydrate-interactions
#4
Gengwei Yan, Takumi Yamaguchi, Tatsuya Suzuki, Saeko Yanaka, Sota Sato, Makoto Fujita, Koichi Kato
Hybridization of a self-assembled, spherical complex with oligosaccharides containing Lewis X, a functional trisaccharide displayed on various cell surfaces, yielded well-defined glycoclusters. The self-assembled glycoclusters exhibited homophilic hyper-assembly in aqueous solution in a Ca2+-dependent manner through specific carbohydrate-carbohydrate interactions, offering a structural scaffold for functional biomimetic systems.
March 20, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28316275/central-growth-factor-loaded-depots-in-bone-tissue-engineering-scaffolds-for-enhanced-cell-attraction
#5
Mandy Quade, Sven Knaack, Ashwini Rahul Akkineni, Anastasia Gabrielyan, Anja Lode, Angela Roesen-Wolff, Michael Gelinsky
Tissue engineering, i.e. the application of stem and progenitor cells in combination with an engineered extracellular matrix, is a promising strategy for bone regeneration. However, its success is limited by the lack of vascularization after implantation. The concept of in situ tissue engineering envisages the recruitment of cells necessary for tissue regeneration from the host environment foregoing ex vivo cell seeding of the scaffold. In this study, we developed a novel scaffold system for enhanced cell attraction which is based on biomimetic mineralized collagen scaffolds equipped with a central biopolymer depot loaded with chemotactic agents...
March 19, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28315813/the-case-for-applying-tissue-engineering-methodologies-to-instruct-human-organoid-morphogenesis
#6
REVIEW
Carlos R Marti-Figueroa, Randolph S Ashton
Three-dimensional organoids derived from human pluripotent stem cell (hPSC) derivatives have become widely used in vitro models for studying development and disease. Their ability to recapitulate facets of normal human development during in vitro morphogenesis produces tissue structures with unprecedented biomimicry. Current organoid derivation protocols primarily rely on spontaneous morphogenesis processes to occur within 3-D spherical cell aggregates with minimal to no exogenous control. This yields organoids containing microscale regions of biomimetic tissues, but at the macroscale (i...
March 15, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28314372/exploring-fluorescent-dyes-at-biomimetic-interfaces-with-second-harmonic-generation-and-molecular-dynamics
#7
Giuseppe Licari, Lukasz Cwiklik, Pavel Jungwirth, Eric Vauthey
The adsorption of a DNA fluorescent probe belonging to the thiazole orange family at the dodecane/water and dodecane/phospholipid/water interfaces has been investigated using a combination of surface-second harmonic generation (SSHG) and all-atomistic molecular dynamics (MD) simulations. Both approaches point to a high affinity of the cationic dye for the dodecane/water interface with a Gibbs free energy of adsorption of the order of -45 kJ/mol. Similar affinity was observed with a monolayer of negatively charged DPPG (1,2-dipalmitoyl-sn-glycero-3-phospho-rac-(1-glycerol)) lipids...
March 17, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28302668/sulphated-glycosaminoglycans-support-an-assortment-of-planarian-rhabdite-structures
#8
Matthew J Hayes
Planaria are soft-bodied, bilateral flatworms of the phylum Playhelminthes. They are covered in cilia and use ciliary-gliding to traverse the substratum while hunting. Their body surface is covered in a layer of viscous slime primarily derived from specialised secretory granules known as rhabdites. The slime must somehow stay associated with the surface of the animal in aqueous environments whilst also lubricating the interface of the animal and the surfaces over which the animal moves. The slime prevents damage to the animal's soft body and also contributes to adhesion to the substratum...
March 16, 2017: Biology Open
https://www.readbyqxmd.com/read/28299928/three-dimensional-crumpled-graphene-based-nanosheets-with-ultrahigh-no2-gas-sensibility
#9
Zhuo Chen, Jinrong Wang, Ahmad Umar, Yao Wang, Hao Li, Guofu Zhou
It is well established that the structures dominate the properties. Inspired by the highly contorted and crumpled maxilloturbinate inside dog nose, herein an artificial nanostructure, i.e. 3D crumpled graphene-based nanosheets, is reported with the simple fabrication, detailed characterizations and efficient gas sensing applications. A facile supramolecular non-covalent assembly is introduced to modify graphene with functional molecules, followed with a lyophilization process to massively transform 2D plane graphene-based nanosheets to 3D crumpled structure...
March 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28293826/utility-of-thermo-alkali-stable-%C3%AE-ca-from-polyextremophilic-bacterium-aeribacillus-pallidus-tshb1-in-biomimetic-sequestration-of-co2-and-as-a-virtual-peroxidase
#10
Himadri Bose, Tulasi Satyanarayana
Aeribacillus pallidus TSHB1 polyextremophilic bacterium produces a γ-carbonic anhydrase (ApCA), which is a homotrimeric biocatalyst with a subunit molecular mass of 32 ± 2 kDa. The enzyme is stable in the pH range between 8.0 and 11.0 and thus alkali-stable and moderately thermostable with T1/2 values of 40 ± 1, 15 ± 1, and 8 ± 0.5 min at 60, 70, and 80 °C, respectively. Activation energy for irreversible inactivation "E d " of carbonic anhydrase is 67.119 kJ mol(-1). The enzyme is stable in the presence of various flue gas contaminants such as SO3(2-),SO4(2-), and NO3(-) and cations Mg(2+), Mn(2+), Ca(2+), and Ba(2+)...
March 14, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28292726/cell-membrane-derived-nanomaterials-for-biomedical-applications
#11
REVIEW
Ronnie H Fang, Yao Jiang, Jean C Fang, Liangfang Zhang
The continued evolution of biomedical nanotechnology has enabled clinicians to better detect, prevent, manage, and treat human disease. In order to further push the limits of nanoparticle performance and functionality, there has recently been a paradigm shift towards biomimetic design strategies. By taking inspiration from nature, the goal is to create next-generation nanoparticle platforms that can more effectively navigate and interact with the incredibly complex biological systems that exist within the body...
March 1, 2017: Biomaterials
https://www.readbyqxmd.com/read/28292176/injectable-polypeptide-hydrogel-as-biomimetic-scaffolds-with-tunable-bioactivity-and-controllable-cell-adhesion
#12
Qinghua Xu, Zhen Zhang, Chunsheng Xiao, Chaoliang He, Xuesi Chen
Injectable hydrogels have been widely investigated for applications in biomedical fields, for instance, as biomimetic scaffolds mimicking the extracellular matrix (ECM). In addition to as scaffolds for mechanical support and transferring of nutrients, the dynamic bioactivity of ECM is another critical factor that affects cell behavior. In this work, a novel injectable poly(L-glutamic acid)-based hydrogel decorated with RGD was fabricated. The presentation of RGD significantly enhanced the cell-matrix interaction, and promoted cell adhesion and proliferation...
March 14, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28291852/osteoclastic-response-on-titanium-surfaces-in-modified-simulated-body-fluid
#13
Moon-Hyoung Kim, Su-Young Lee, Seong-Joo Heo, Seong-Kyun Kim, Myung-Joo Kim, Jai-Young Koak
PURPOSE: It was hypothesized that calcium phosphate (CaP) deposition onto Ti surfaces using biomimetic deposition contributed to not only improving osteogenesis but also suppressing osteoclastogenesis in terms of high surface hydrophilicity. MATERIALS AND METHODS: Ti discs with two different surfaces were prepared: machined and anodic oxidized surfaces. The specimens of two different surfaces were soaked in modified simulated body fluid solution for 14 days at physiologic condition...
March 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28291351/what-can-we-learn-from-a-biomimetic-model-of-nature-s-oxygen-evolving-complex
#14
Satadal Paul, Nicholas Cox, Dimitrios A Pantazis
A recently reported synthetic complex with a Mn4CaO4 core represents a remarkable structural mimic of the Mn4CaO5 cluster in the oxygen-evolving complex (OEC) of photosystem II (Zhang et al., Science 2015, 348, 690). Oxidized samples of the complex show electron paramagnetic resonance (EPR) signals at g ≈ 4.9 and 2, similar to those associated with the OEC in its S2 state (g ≈ 4.1 from an S = (5)/2 form and g ≈ 2 from an S = (1)/2 form), suggesting similarities in the electronic as well as geometric structure...
March 14, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28290206/diverse-applications-of-nanomedicine
#15
Beatriz Pelaz, Christoph Alexiou, Ramon A Alvarez-Puebla, Frauke Alves, Anne M Andrews, Sumaira Ashraf, Lajos P Balogh, Laura Ballerini, Alessandra Bestetti, Cornelia Brendel, Susanna Bosi, Monica Carril, Warren C W Chan, Chunying Chen, Xiaodong Chen, Xiaoyuan Chen, Zhen Cheng, Daxiang Cui, Jianzhong Du, Christian Dullin, Alberto Escudero, Neus Feliu, Mingyuan Gao, Michael George, Yury Gogotsi, Arnold Grünweller, Zhongwei Gu, Naomi J Halas, Norbert Hampp, Roland K Hartmann, Mark C Hersam, Patrick Hunziker, Ji Jian, Xingyu Jiang, Philipp Jungebluth, Pranav Kadhiresan, Kazunori Kataoka, Ali Khademhosseini, Jindřich Kopeček, Nicholas A Kotov, Harald F Krug, Dong Soo Lee, Claus-Michael Lehr, Kam W Leong, Xing-Jie Liang, Mei Ling Lim, Luis M Liz-Marzán, Xiaowei Ma, Paolo Macchiarini, Huan Meng, Helmuth Möhwald, Paul Mulvaney, Andre E Nel, Shuming Nie, Peter Nordlander, Teruo Okano, Jose Oliveira, Tai Hyun Park, Reginald M Penner, Maurizio Prato, Victor Puntes, Vincent M Rotello, Amila Samarakoon, Raymond E Schaak, Youqing Shen, Sebastian Sjöqvist, Andre G Skirtach, Mahmoud G Soliman, Molly M Stevens, Hsing-Wen Sung, Ben Zhong Tang, Rainer Tietze, Buddhisha N Udugama, J Scott VanEpps, Tanja Weil, Paul S Weiss, Itamar Willner, Yuzhou Wu, Lily Yang, Zhao Yue, Qian Zhang, Qiang Zhang, Xian-En Zhang, Yuliang Zhao, Xin Zhou, Wolfgang J Parak
The design and use of materials in the nanoscale size range for addressing medical and health-related issues continues to receive increasing interest. Research in nanomedicine spans a multitude of areas, including drug delivery, vaccine development, antibacterial, diagnosis and imaging tools, wearable devices, implants, high-throughput screening platforms, etc. using biological, nonbiological, biomimetic, or hybrid materials. Many of these developments are starting to be translated into viable clinical products...
March 14, 2017: ACS Nano
https://www.readbyqxmd.com/read/28289247/three-dimensional-bioprinting-strategies-for-tissue-engineering
#16
Yu Shrike Zhang, Rahmi Oklu, Mehmet Remzi Dokmeci, Ali Khademhosseini
Over the past decades, many approaches have been developed to fabricate biomimetic extracellular matrices of desired properties for engineering functional tissues. However, the inability of these techniques to precisely control the spatial architecture has posed a significant challenge in producing complex tissues. 3D bioprinting technology has emerged as a potential solution by bringing unprecedented freedom and versatility in depositing biological materials and cells in a well-controlled manner in the 3D volumes, therefore achieving precision engineering of functional tissues...
March 13, 2017: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/28286038/multi-stimuli-responsive-biohybrid-nanoparticles-with-cross-linked-albumin-coronae-self-assembled-by-a-polymer-protein-biodynamer
#17
Lin Wang, Li Liu, Bingyang Dong, Hanying Zhao, Mingming Zhang, Wenjuan Chen, Yanhang Hong
A thermoresponsive polymer-protein biodynamer was prepared via the bioconjugation of an aliphatic aldehyde-functionalized copolymer to hydrazine-modified bovine serum albumin (BSA) through reversible pyridylhydrazone linkages. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and size exclusion chromatography (SEC) results indicated that the pyridylhydrazone linkages cleaved in an intracellular-mimicking acidic milieu, thus leading to the release of BSA. The dynamic character of the protein biodynamer was demonstrated by exchange reactions with aldehyde-containing molecules...
March 8, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28282110/collagen-based-photoactive-agent-for-tissue-bonding
#18
Justina Pupkaite, Manuel Ahumada, Sarah Mclaughlin, Maha Temkit, Sura Alaziz, Richard Seymour, Marc Ruel, Irene Kochevar, May Griffith, Erik J Suuronen, Emilio I Alarcon
Using a combination of methacrylated collagen and the photosensitizer rose Bengal, a new light-activated biomimetic material for tissue sutureless bonding was developed. This formulation was cross-linked using green light. In vivo tests in mice demonstrate the suitability of the material for sutureless wound closure.
March 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28282044/predatory-behaviour-in-synthetic-protocell-communities
#19
Yan Qiao, Mei Li, Richard Booth, Stephen Mann
Recent progress in the chemical construction of colloidal objects comprising integrated biomimetic functions is paving the way towards rudimentary forms of artificial cell-like entities (protocells). Although several new types of protocells are currently available, the design of synthetic protocell communities and investigation of their collective behaviour has received little attention. Here we demonstrate an artificial form of predatory behaviour in a community of protease-containing coacervate microdroplets and protein-polymer microcapsules (proteinosomes) that interact via electrostatic binding...
February 2017: Nature Chemistry
https://www.readbyqxmd.com/read/28280328/gambogic-acid-loaded-biomimetic-nanoparticles-in-colorectal-cancer-treatment
#20
Zhen Zhang, Hanqing Qian, Mi Yang, Rutian Li, Jing Hu, Li Li, Lixia Yu, Baorui Liu, Xiaoping Qian
Gambogic acid (GA) is expected to be a potential new antitumor drug, but its poor aqueous solubility and inevitable side effects limit its clinical application. Despite these inhe rent defects, various nanocarriers can be used to promote the solubility and tumor targeting of GA, improving antitumor efficiency. In addition, a cell membrane-coated nanoparticle platform that was reported recently, unites the customizability and flexibility of a synthetic copolymer, as well as the functionality and complexity of natural membrane, and is a new synthetic biomimetic nanocarrier with improved stability and biocompatibility...
2017: International Journal of Nanomedicine
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