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Babloo Sharma, Susanne Striegler
In an effort to develop biomimetic glycosyl transfer catalysts, a polymerization protocol was developed that is applicable to the synthesis of crosslinked microgels via UV-initiated free radical polymerization of miniemulsions at ambient temperature and below. The catalytic activity of the microgels derived from butyl acrylate, EGDMA and a catalyst-precursor ligand was established using the hydrolysis of 4-methylumbelliferyl -D-galactopyranoside as a model reaction. The microgel-catalyzed hydrolysis was up to 3 × 105-fold accelerated over the background reaction and notably 38-fold faster than the hydrolysis catalyzed by its low molecular weight analog...
March 16, 2018: Biomacromolecules
Stefan Ilic, Usha Pandey Kadel, Yasemin Basdogan, John A Keith, Ksenija D Glusac
Thermodynamic hydricities (ΔGH- ) in acetonitrile and dimethyl sulfoxide have been calculated and experimentally measured for several metal-free hydride donors: NADH analogs (BNAH, CN-BNAH, Me-MNAH, HEH), methylene tetrahydromethanopterin analogs (BIMH, CAFH), acridine derivatives (Ph-AcrH, Me2 N-AcrH, T-AcrH, 4OH, 2OH, 3NH) and a triarylmethane derivative (6OH). The calculated hydricity values, obtained using density functional theory, showed a reasonably good match (within 3 kcal/mol) with the experimental values, obtained using "potential-pKa" and "hydride-transfer" methods...
March 16, 2018: Journal of the American Chemical Society
Lesley W Chan, Daniel E Morse, Michael J Gordon
Near- and sub-wavelength photonic structures are used by numerous organisms (e.g., insects, cephalopods, fish, birds) to create vivid and often dynamically-tunable colors, as well as create, manipulate, or capture light for vision, communication, crypsis, photosynthesis, and defense. This review introduces the physics of moth eye (ME)-like, biomimetic nanostructures and discusses their application to reduce optical losses and improve efficiency of various optoelectronic devices, including photodetectors, photovoltaics, imagers, and light emitting diodes...
March 16, 2018: Bioinspiration & Biomimetics
IlKyoo Koh, Junghwa Cha, Junseong Park, Junjeong Choi, Seok-Gu Kang, Pilnam Kim
Glioblastoma multiforme (GBM) is the most common brain tumor with very aggressive and infiltrative. Extracellular matrix (ECM) plays pivotal roles in the infiltrative characteristics of GBM. To understand the invasive characteristic of GBM, it is necessary to study cell-ECM interaction in the physiologically relevant biomimetic model that recapitulates the GBM-specific ECM microenvironment. Here, we propose biomimetic GBM-specific ECM microenvironment for studying mode and dynamics of glioblastoma cell invasion...
March 15, 2018: Scientific Reports
Ja Hye Myung, Michael J Eblan, Joseph M Caster, Sinjung Park, Michael J Poellmann, Kyle Wang, Joel E Tepper, Kevin A Tam, Seth M Miller, Colette Shen, Ronald C Chen, Tian Zhang, Bhishamjit Chera, Andrew Z Wang, Seungpyo Hong
PURPOSE: We aimed to examine the effects of multivalent binding and biomimetic cell rolling on the sensitivity and specificity of circulating tumor cell (CTC) capture. We also investigated the clinical significance of CTCs and their kinetic profiles in cancer patients undergoing radiotherapy (RT) treatment. EXPERIMENTAL DESIGN: Patients with histologically confirmed primary carcinoma undergoing RT, with or without chemotherapy, were eligible for enrollment. Peripheral blood was collected prospectively at up to 5 time points, including prior to RT, at the first week, mid-point and final week of treatment, as well as 4 to 12 weeks after completion of RT...
March 15, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
V Vasilca, A Sadeghpour, S Rawson, L E Hawke, S A Baldwin, T Wilkinson, D Bannister, V L G Postis, M Rappolt, S P Muench, L J C Jeuken
Screening assays performed against membrane protein targets (e.g. phage display) are hampered by issues arising from protein expression and purification, protein stability in detergent solutions and epitope concealment by detergent micelles. Here, we have studied a fast and simple method to improve screening against membrane proteins: spherical-supported bilayer lipid membranes ("SSBLM"). SSBLMs can be quickly isolated via low-speed centrifugation and redispersed in liquid solutions while presenting the target protein in a native-like lipid environment...
March 12, 2018: Analytical Biochemistry
Felix A Blyakhman, Nikita A Buznikov, Tatyana F Sklyar, Alexander P Safronov, Elizaveta V Golubeva, Andrey V Svalov, Sergey Yu Sokolov, Grigory Yu Melnikov, Iñaki Orue, Galina V Kurlyandskaya
Hydrogels are biomimetic materials widely used in the area of biomedical engineering and biosensing. Ferrogels (FG) are magnetic composites capable of functioning as magnetic field sensitive transformers and field assisted drug deliverers. FG can be prepared by incorporating magnetic nanoparticles (MNPs) into chemically crosslinked hydrogels. The properties of biomimetic ferrogels for multifunctional biosensor applications can be set up by synthesis. The properties of these biomimetic ferrogels can be thoroughly controlled in a physical experiment environment which is much less demanding than biotests...
March 15, 2018: Sensors
Katherine D Hills, Daniela A Oliveira, Nicholas D Cavallaro, Carmen L Gomes, Eric S McLamore
We demonstrate a sensing mechanism for rapid detection of Listeria monocytogenes in food samples using the actuation of chitosan-aptamer nanobrush borders. The bio-inspired soft material and sensing strategy mimic natural symbiotic systems, where low levels of bacteria are selectively captured from complex matrices. To engineer this biomimetic system, we first develop reduced graphene oxide/nanoplatinum (rGO-nPt) electrodes, and characterize the fundamental electrochemical behavior in the presence and absence of chitosan nanobrushes during actuation (pH-stimulated osmotic swelling)...
March 15, 2018: Analyst
Nicole L Ing, Ryan K Spencer, Son H Luong, Hung D Nguyen, Allon I Hochbaum
Examples of long-range electronic conductivity are rare in biological systems. The observation of micrometer-scale electronic transport through protein wires produced by bacteria is therefore notable, providing an opportunity to study fundamental aspects of conduction through protein-based materials and natural inspiration for bioelectronics materials. Borrowing sequence and structural motifs from these conductive protein fibers, we designed self-assembling peptides that form electronically conductive nanofibers under aqueous conditions...
March 14, 2018: ACS Nano
Raissa Schor, Russell Cox
Covering: 1893 to 2017Harold Raistrick was involved in the discovery of many of the most important classes of fungal metabolites during the 20th century. This review focusses on how these discoveries led to developments in isotopic labelling, biomimetic chemistry and the discovery, analysis and exploitation of biosynthetic gene clusters for major classes of fungal metabolites including: alternariol; geodin and metabolites of the emodin pathway; maleidrides; citrinin and the azaphilones; dehydrocurvularin; mycophenolic acid; and the tropolones...
March 14, 2018: Natural Product Reports
Xiangyu Wang, Donghai Xia, Hai Han, Kun Peng, Peijie Zhu, Jacques Crommen, Qiqin Wang, Zhengjin Jiang
The rapid development of monoclonal antibodies (mAbs) in therapeutic and diagnostic applications has necessitated the advancement of mAbs purification technologies. In this study, a biomimetic small peptide ligand 3,5-di-tert-butyl-4-hydroxybenzoic acid-Arg-Arg-Gly (DAAG) functionalized monolith was fabricated through a metal ion chelation-based multi-step approach. The resulting monolith showed good chromatographic performance. Compared with the Ni2+ based IMAC monolith, the DAAG functionalized monolith exhibited not only excellent specificity but also higher dynamic binding capacity (DBC)...
August 9, 2018: Analytica Chimica Acta
Anne Bernhardt, Birgit Paul, Michael Gelinsky
BACKGROUND: Collagens of marine origin are applied increasingly as alternatives to mammalian collagens in tissue engineering. The aim of the present study was to develop a biphasic scaffold from exclusively marine collagens supporting both osteogenic and chondrogenic differentiation and to find a suitable setup for in vitro chondrogenic and osteogenic differentiation of human mesenchymal stroma cells (hMSC). METHODS: Biphasic scaffolds from biomimetically mineralized salmon collagen and fibrillized jellyfish collagen were fabricated by joint freeze-drying and crosslinking...
March 13, 2018: Marine Drugs
Brian Luk, Yao Jiang, Jonathan Copp, Che-Ming J Hu, Nishta Krishnan, Weiwei Gao, Shulin Li, Ronnie H Fang, Liangfang Zhang
Within the body, cellular recognition is mediated in large part by receptor-ligand interactions that result from the surface marker expression of the participant cells. In the case of immune cells, these interactions can be highly specific, enabling them to carry out their protective functions in fighting off infection and malignancy. In this work, we demonstrate the biomimetic targeting of antigen-specific immune cell populations by using nanoparticles functionalized with natural membrane derived from cells expressing the cognate antigen...
March 13, 2018: Molecular Pharmaceutics
Heran Li, Haiting Li, Chen Wei, Jia Ke, Jing Li, Lu Xu, Hongzhuo Liu, Yangyang, Sanming Li, Mingshi Yang
In this study, spherical shaped chiral mesoporous silica nanoparticles (CMS) was biomimetic synthesized using histidine derivatives (C16 -L-histidine) as template via the sol-gel reaction and employed as poorly water-soluble drug nimodipine (NMP) carrier. Characteristics of CMS and its application as drug carrier were intensively investigated and compared with MCM41. Then NMP was respectively loaded into CMS and MCM41 with the drug: carrier weight ratio of 2:1. Structural features of NMP before and after drug loading were systemically characterized...
March 9, 2018: European Journal of Pharmaceutical Sciences
Di Huang, Lulu Niu, Jian Li, Jingjing Du, Yan Wei, Yinchun Hu, Xiaojie Lian, Weiyi Chen, Kaiqun Wang
In order to improve the osteogenic activity and mechanical strength of the guided bone regeneration (GBR) membrane for repairing bone defect, nano-hydroxyapatite/chitosan (nHA/CS) composite microspheres were prepared through in situ biomimetic method, then composite microspheres were incorporated into CS membrane. The morphologies and mechanical properties of the composite membranes were investigated through scanning electronic microscopy (SEM) and universal mechanical testing machine. The results show that the in situ biomimetic nHA/CS microspheres were embedded in CS membrane and were integrated tightly with CS matrix...
March 7, 2018: Journal of the Mechanical Behavior of Biomedical Materials
Hua Yu, Jing Han, Shangjie An, Gang Xie, Sanping Chen
Metal-organic frameworks (MOFs) as a new class of porous materials have attracted increasing attention in the field of biomimetic catalysis. This study firstly reports a mixed valence state Ce-MOF possessing intrinsic catalytic activity towards thionine (Thi), and its application in constructing an amplified electrochemical aptasensor for thrombin detection. As noticed, the novel catalytic process combines the advantages of 3D infinite extension of the Ce(III, IV)-MOF skeleton containing large amounts of catalytic sites and spontaneous recycling of the Ce(III)/Ce(IV) for electrochemical reduction of Thi, thereby presenting amplified electrochemical signals...
March 5, 2018: Biosensors & Bioelectronics
Pi Liu, Yan Zhao, Xiaoguo Liu, Jixue Sun, Dede Xu, Yang Li, Qian Li, Lihua Wang, Sichun Yang, Chunhai Fan, Jianping Lin
Shape reconfiguration of membrane protein channels is highly regulated under physiological conditions for gated transportation. Nevertheless, mechanistic understanding of molecular channels remains challenging due to the difficulty in probing gating-associated subtle structural changes. Here we show that charge neutralization can drive shape reconfiguration of a biomimetic 6-helix bundle DNA nanotube (6HB). Specifically, 6HB adopts a compact state when being neutralized by Mg2+; and monovalent ions (Na+) switch it to the expansion state, as revealed by molecular dynamics (MD) simulation, small angle X-ray scattering (SAXS) and Förster resonance energy transfer (FRET) characterization...
March 12, 2018: Angewandte Chemie
Christopher McCleese, Zhanqian Yu, Nopondo Ndoh Esemoto, Charles Kolodziej, Buddhadev Maiti, Srijana Bhandari, Barry D Dunietz, Clemens Burda, Marcin Ptaszek
Excitonically-coupled bacteriochlorin (BC) dimers constitute a primary electron donor (special pair) in bacterial photosynthesis and absorbing units in light-harvesting antenna. However, the exact nature of the excited state of these dyads is still not fully understood. Here, we report a detailed spectroscopic and computational investigation of a series of symmetrical bacteriochlorin dimers, where the bacteriochlorins are connected either directly or by a phenylene bridge with variable length. The excited state of these dyads is quenched in high-dielectric solvents, which we attribute to photoinduced charge transfer...
March 10, 2018: Journal of Physical Chemistry. B
Sara Shahbazi, Ali Zamanian, Mohammad Pazouki, Yaser Jafari
A new total biomimetic technique based on both the water uptake and degradation processes is introduced in this study to provide an interesting procedure to fabricate a bioactive and biodegradable synthetic scaffold, which has a good mechanical and structural properties. The optimization of effective parameters to scaffold fabrication was done by response surface methodology/central composite design (CCD). With this method, a synthetic scaffold was fabricated which has a uniform and open-interconnected porous structure with the largest pore size of 100-200μm...
May 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
Teofil Jesionowski, Małgorzata Norman, Sonia Żółtowska-Aksamitowska, Iaroslav Petrenko, Yvonne Joseph, Hermann Ehrlich
The biosynthesis, chemistry, structural features and functionality of spongin as a halogenated scleroprotein of keratosan demosponges are still paradigms. This review has the principal goal of providing thorough and comprehensive coverage of spongin as a naturally prefabricated 3D biomaterial with multifaceted applications. The history of spongin's discovery and use in the form of commercial sponges, including their marine farming strategies, have been analyzed and are discussed here. Physicochemical and material properties of spongin-based scaffolds are also presented...
March 9, 2018: Marine Drugs
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