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https://www.readbyqxmd.com/read/28087551/cost-effectiveness-of-superficial-femoral-artery-endovascular-interventions-in-the-uk-and-germany-a-modelling-study
#1
Benjamin C Kearns, Steven M Thomas
OBJECTIVES: To assess the lifetime costs and cost-effectiveness of 5 endovascular interventions to treat superficial femoral arterial disease. DESIGN: A model-based health economic evaluation. An existing decision analytical model was used, with updated effectiveness data taken from the literature, and updated costs based on purchasing prices. SETTING: UK and German healthcare perspectives were considered. PARTICIPANTS: Patients with intermittent claudication of the femoropopliteal arteries eligible for endovascular treatment...
January 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28087484/inhibition-of-bacterial-adhesion-and-biofilm-formation-by-dual-functional-textured-and-nitric-oxide-releasing-surfaces
#2
Li-Chong Xu, Yaqi Wo, Mark E Meyerhoff, Christopher A Siedlecki
: In separate prior studies, physical topographic surface modification or nitric oxide (NO) release has been demonstrated to each be an effective approach to inhibit and control bacterial adhesion and biofilm formation on polymeric surfaces. Such approaches can prevent biomaterial-associated infection without causing the antibiotic resistance of the strain. In this work, both techniques were successfully integrated and applied to a polyurethane (PU) biomaterial surface that bears ordered pillar topographies (400/400 nm and 500/500 nm patterns) at the top surface and a S-nitroso-N-acetylpenicillamine (SNAP, NO donor) doped sub-layer in the middle, via a soft lithography two-stage replication process...
January 10, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28080074/synthesis-of-briarane-diterpenoids-biomimetic-transannular-oxa-6%C3%AF-electrocyclization-induced-by-a-uva-uvc-photoswitch
#3
Andrew J Hall, Stéphane P Roche, Lyndon M West
A biomimetic synthesis of briareolate ester B (3) from briareolate ester L (1) via the intermediate briareolate ester G (2) has been achieved through a unique transannular oxa-6π electrocyclization induced by UVA light. UVC irradiation of 3 triggered a rapid retro-6π electrocyclization to establish an unprecedented photochromic switch. In the ground state, reaction of 1 led to the formation of a polycyclic γ-spiroketal γ-lactone 5, architecturally related to the ether-bridged cembranoids of the cladiellin class...
January 12, 2017: Organic Letters
https://www.readbyqxmd.com/read/28080059/a-computational-approach-for-modeling-neutron-scattering-data-from-lipid-bilayers
#4
Jan-Michael Y Carrillo, John Katsaras, Bobby G Sumpter, Rana Ashkar
Biological cell membranes are responsible for a range of structural and dynamical phenomena crucial to a cell's well-being and its associated functions. Due to the complexity of cell membranes, lipid bilayer systems are often used as biomimetic models. These systems have led to significant insights into vital membrane phenomena such as domain formation, passive permeation and protein insertion. Experimental observations of membrane structure and dynamics are, however, limited in resolution, both spatially and temporally...
January 12, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28079210/probing-nonlinear-optical-coefficients-in-self-assembled-peptide-nanotubes
#5
Soma Khanra, Kartik Ghosh, Fabio F Ferreira, Wendel A Alves, Francesco Punzo, Ping Yu, Suchismita Guha
Self-assembled l,l-diphenylalanine (FF) peptide micro/nanotubes represent a class of biomimetic materials with a non-centrosymmetric crystal structure and strong piezoelectricity. The peptide nanotubes synthesized by a liquid phase method yield tube lengths in the hundreds of micron range, inner diameters in the few hundred nanometer range, and outer diameters in the 5-15 μm range. Second harmonic generation (SHG) polarimetry from individual self-assembled FF nanotubes is used to obtain the nonlinear (NLO) optical coefficients as a function of the tube diameter and thermal treatment...
January 12, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28079165/oriented-and-ordered-biomimetic-remineralization-of-the-surface-of-demineralized-dental-enamel-using-hap-acp-nanoparticles-guided-by-glycine
#6
Haorong Wang, Zuohui Xiao, Jie Yang, Danyang Lu, Anil Kishen, Yanqiu Li, Zhen Chen, Kehua Que, Qian Zhang, Xuliang Deng, Xiaoping Yang, Qing Cai, Ning Chen, Changhong Cong, Binbin Guan, Ting Li, Xu Zhang
Achieving oriented and ordered remineralization on the surface of demineralized dental enamel, thereby restoring the satisfactory mechanical properties approaching those of sound enamel, is still a challenge for dentists. To mimic the natural biomineralization approach for enamel remineralization, the biological process of enamel development proteins, such as amelogenin, was simulated in this study. In this work, carboxymethyl chitosan (CMC) conjugated with alendronate (ALN) was applied to stabilize amorphous calcium phosphate (ACP) to form CMC/ACP nanoparticles...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28078719/carbon-nanotube-supported-bio-inspired-nickel-catalyst-and-its-integration-in-hybrid-hydrogen-air-fuel-cells
#7
Solène Gentil, Noémie Lalaoui, Arnab Dutta, Yannig Nedellec, Serge Cosnier, Wendy J Shaw, Vincent Artero, Alan Le Goff
A biomimetic nickel bis-diphosphine complex incorporating the amino acid arginine in the outer coordination sphere was immobilized on modified carbon nanotubes (CNTs) through electrostatic interactions. The functionalized redox nanomaterial exhibits reversible electrocatalytic activity for the H2 /2 H(+) interconversion from pH 0 to 9, with catalytic preference for H2 oxidation at all pH values. The high activity of the complex over a wide pH range allows us to integrate this bio-inspired nanomaterial either in an enzymatic fuel cell together with a multicopper oxidase at the cathode, or in a proton exchange membrane fuel cell (PEMFC) using Pt/C at the cathode...
January 12, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28075598/organocatalytic-regioselective-concomitant-thiocyanation-and-acylation-of-oxiranes-using-aroyl-isothiocyanates
#8
Anju Modi, Wajid Ali, Bhisma K Patel
A regioselective and concomitant transfer of thiocyanate (-SCN) and aroyl/acyl (-COR) groups from aroyl/acyl isothiocyanates onto oxiranes was achieved, giving thiocyanato benzoates in 100% atom economy. In this biomimetic organocatalytic process, one part (-SCN) of aroyl/acyl isothiocyanates acts as the nucleophile whereas the other half (-COR) serves as an electrophilic partner.
January 11, 2017: Organic Letters
https://www.readbyqxmd.com/read/28074936/hygroscopic-motions-of-fossil-conifer-cones
#9
Simon Poppinga, Nikolaus Nestle, Andrea Šandor, Bruno Reible, Tom Masselter, Bernd Bruchmann, Thomas Speck
Conifer cones represent natural, woody compliant structures which move their scales as passive responses to changes in environmental humidity. Here we report on water-driven opening and closing motions in coalified conifer cones from the Eemian Interglacial (approx. 126,000-113,000 years BP) and from the Middle Miocene (approx. 16.5 to 11.5 million years BP). These cones represent by far the oldest documented evidence of plant parts showing full functionality of such passive hydraulically actuated motion. The functional resilience of these structures is far beyond the biological purpose of seed dispersal and protection and is because of a low level of mineralization of the fossils...
January 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28069413/characterization-of-planar-biomimetic-lipid-films-composed-of-phosphatidylethanolamines-and-phosphatidylglycerols-from-escherichia-coli
#10
Dorota Konarzewska, Joanna Juhaniewicz, Alişan Güzeloğlu, Sławomir Sęk
We have characterized planar lipid films composed of phosphatidylethanolamines (PE) and phosphatidylglycerols (PG) from E. coli bacteria. The nature of the interactions and miscibility of PE and PG components within mixed lipid films was evaluated based on surface pressure measurements and Brewster angle microscopy imaging at the air-water interface. We have found that PE and PG components show tendency to form separated domains at surface pressures relevant for biological membranes. Further, we have directly compared mechanisms of formation of supported lipid bilayers either on mica or Au(111) by spreading of small unilamellar vesicles...
January 6, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28068758/strontium-doped-amorphous-calcium-phosphate-porous-microspheres-synthesized-through-a-microwave-hydrothermal-method-using-fructose-1-6-bisphosphate-as-an-organic-phosphorus-source-application-in-drug-delivery-and-enhanced-bone-regeneration
#11
Weilin Yu, Tuan-Wei Sun, Chao Qi, Zhen-Yu Ding, Hua-Kun Zhao, Feng Chen, Dao-Yun Chen, Ying-Jie Zhu, Zhongmin Shi, Yaohua He
Nanostructured calcium phosphate (CaP) porous microspheres are of great potential in drug delivery and bone regeneration due to their large specific surface area, biocompatibility and similarity to inorganic component of osseous tissue. In this work, strontium (Sr)-doped amorphous calcium phosphate porous microspheres (SrAPMs) were synthesized through a microwave-hydrothermal method using fructose 1,6-bisphosphate trisodium salt (FBP) as the source of phosphate ions. The SrAPMs showed a mesoporous structure and a relatively high specific area...
January 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28068469/porphyrin-based-porous-organic-frameworks-as-a-biomimetic-catalyst-for-highly-efficient-colorimetric-immunoassay
#12
Xiao Deng, Yishan Fang, Sha Lin, Qian Cheng, Qingyun Liu, Xiaomei Zhang
Herein, we synthesized a cost-effective porphyrin based covalent organic polymer, namely FePor-TFPA-COP, through an easy aromatic substitution reaction between pyrrole and tris(4-formylphenyl)amine (TFPA). The triangular pyramid shaped, N-centric structure of TFPA facilitated the formation of FePor-TFPA-COP with three-dimensional porous structure, larger surface area and abundant surface catalytic active sites. FePor-TFPA-COP exhibited strong intrinsic peroxidase activity toward a classical peroxidase substrate 3,3',5,5'-tetramethylbenzidine (TMB) in the presence of H2O2...
January 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28068389/cooperative-interactions-between-different-classes-of-disordered-proteins-play-a-functional-role-in-the-nuclear-pore-complex-of-baker-s-yeast
#13
David Ando, Ajay Gopinathan
Nucleocytoplasmic transport is highly selective, efficient, and is regulated by a poorly understood mechanism involving hundreds of disordered FG nucleoporin proteins (FG nups) lining the inside wall of the nuclear pore complex (NPC). Previous research has concluded that FG nups in Baker's yeast (S. cerevisiae) are present in a bimodal distribution, with the "Forest Model" classifying FG nups as either di-block polymer like "trees" or single-block polymer like "shrubs". Using a combination of coarse-grained modeling and polymer brush modeling, the function of the di-block FG nups has previously been hypothesized in the Di-block Copolymer Brush Gate (DCBG) model to form a higher-order polymer brush architecture which can open and close to regulate transport across the NPC...
2017: PloS One
https://www.readbyqxmd.com/read/28068309/biomimetic-spinning-of-artificial-spider-silk-from-a-chimeric-minispidroin
#14
Marlene Andersson, Qiupin Jia, Ana Abella, Xiau-Yeen Lee, Michael Landreh, Pasi Purhonen, Hans Hebert, Maria Tenje, Carol V Robinson, Qing Meng, Gustavo R Plaza, Jan Johansson, Anna Rising
Herein we present a chimeric recombinant spider silk protein (spidroin) whose aqueous solubility equals that of native spider silk dope and a spinning device that is based solely on aqueous buffers, shear forces and lowered pH. The process recapitulates the complex molecular mechanisms that dictate native spider silk spinning and is highly efficient; spidroin from one liter of bacterial shake-flask culture is enough to spin a kilometer of the hitherto toughest as-spun artificial spider silk fiber.
January 9, 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/28068104/unraveling-interactions-between-ionic-liquids-and-phospholipid-vesicles-using-nanoplasmonic-sensing
#15
Joanna Witos, Giacomo Russo, Suvi-Katriina Ruokonen, Susanne Kristina Wiedmer
Owing to their unique properties and unlimited structural combinations, the ubiquitous use of ionic liquids (ILs) is steadily increasing. The objective of the present work is to shed light into the effects of amidinium- and phosphonium-based ILs on phospholipid vesicles using a nanoplasmonic sensing measurement technique. A new and relatively simple method was developed for the immobilization of large unilamellar vesicles on two different hydrophilic surfaces composed of titanium dioxide and silicon nitride nanolayers...
January 9, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28067353/biomimetic-mineralization-of-metal-organic-frameworks-around-polysaccharides
#16
Kang Liang, Ru Wang, Manon Boutter, Cara M Doherty, Xavier Mulet, Joseph J Richardson
Biomimetic mineralization exploits natural biomineralization processes for the design and fabrication of synthetic functional materials. Here, we report for the first time the use of carbohydrates (polysaccharides) for the biomimetic crystallization of metal-organic frameworks. This discovery greatly expands the potential and diversity of biomimetic approaches for the design, synthesis, and functionalization of new bio-metal-organic framework composite materials.
January 9, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28067344/biomimetically-crystallized-protease-resistant-zinc-phosphate-decorated-with-gold-atomic-clusters-for-bioimaging
#17
Anushree Dutta, Deepanjalee Dutta, Pallab Sanpui, Arun Chattopadhyay
A luminescent probe synthesised via biomimetic crystallization of zinc phosphate in the presence of protein fragment stabilised gold (Au) nanoclusters is reported. The engineered probe - with Au nanoclusters assembled on the crystal - was protease resistant and offered efficient bioimaging and uptake studies.
January 9, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28067335/dopamine-functionalized-mesoporous-onion-like-silica-as-a-new-matrix-for-immobilization-of-lipase-candida-sp-99-125
#18
Junkai Gao, Yanjun Jiang, Jinshu Lu, Zhi Han, Jiajia Deng, Yan Chen
Dopmine functionalized mesoporous onion-like silica (DPMS) was synthesized via a biomimetic coating, and lipase Candida sp. 99-125 (LCS) was immobilized in DPMS (LCS@DPMS) by physical adsorption in this study. The DPMS was characterized by SEM, TEM, BET and FT-IR, and it was shown that the DPMS had clear multishell structures with large surface area of 419 m(2)/g. The activity, pH stability, thermal stability, storage stability, and reusability of the LCS@DPMS were investigated in detail. The stabilities of LCS@DPMS were improved significantly compared to the free lipase and LCS@MS (LCS immobilized in unfunctionalized mesoporous onion-like silica by physical adsorption)...
January 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28066993/developing-a-biomimetic-tooth-bud-model
#19
Elizabeth E Smith, Weibo Zhang, Nathan R Schiele, Ali Khademhosseini, Catherine K Kuo, Pamela C Yelick
A long-term goal is to bioengineer, fully functional, living teeth for regenerative medicine and dentistry applications. Biologically based replacement teeth would avoid insufficiencies of the currently used dental implants. Using natural tooth development as a guide, a model was fabricated using post-natal porcine dental epithelial (pDE), porcine dental mesenchymal (pDM) progenitor cells, and human umbilical vein endothelial cells (HUVEC) encapsulated within gelatin methacrylate (GelMA) hydrogels. Previous publications have shown that post-natal DE and DM cells seeded onto synthetic scaffolds exhibited mineralized tooth crowns composed of dentin and enamel...
January 8, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28065316/single-molecule-measurements-to-study-polymerization-dynamics-of-ftsz-ftsa-copolymers
#20
N Baranova, M Loose
Bacterial cytokinesis is commonly initiated by the Z-ring, a dynamic cytoskeletal structure that assembles at the site of division. Its primary component is FtsZ, a tubulin-like GTPase, that like its eukaryotic relative forms protein filaments in the presence of GTP. Since the discovery of the Z-ring 25years ago, various models for the role of FtsZ have been suggested. However, important information about the architecture and dynamics of FtsZ filaments during cytokinesis is still missing. One reason for this lack of knowledge has been the small size of bacteria, which has made it difficult to resolve the orientation and dynamics of individual FtsZ filaments in the Z-ring...
2017: Methods in Cell Biology
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