Jérémie Joffre, Lauren Rodriguez, Zachary A Matthay, Elliot Lloyd, Alexander T Fields, Roland J Bainton, Philip Kurien, Anita Sil, Carolyn S Calfee, Prescott G Woodruff, David J Erle, Carolyn Hendrickson, Matthew F Krummel, Charles R Langelier, Michael A Matthay, Lucy Z Kornblith, Judith Hellman
Rationale: Autopsy and biomarker studies suggest that endotheliopathy contributes to coronavirus disease (COVID-19)-associated acute respiratory distress syndrome. However, the effects of COVID-19 on the lung endothelium are not well defined. We hypothesized that the lung endotheliopathy of COVID-19 is caused by circulating host factors and direct endothelial infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Objectives: We aimed to determine the effects of SARS-CoV-2 or sera from patients with COVID-19 on the permeability and inflammatory activation of lung microvascular endothelial cells...
October 15, 2022: American Journal of Respiratory and Critical Care Medicine