keyword
https://read.qxmd.com/read/38321767/alkaloids-from-fritillaria-przewalskii%C3%A2-bulbs-and-their-anti-alzheimer-s-disease-activities
#1
JOURNAL ARTICLE
Rui-Xue Ma, Shu-Li Zhang, Feng-Ke Lin, Ming-Ming Zhu, Dong-Rong Zhu, Yu-Ming Liu
Three undescribed isosteroidal alkaloids, przewalskines A - C (1-3), as well as seven known alkaloids (4-10) were obtained from Fritillaria przewalskii bulbs. Their structures were deduced by extensive HRESIMS, 1D NMR, and 2D NMR analyses and their bioactivities were evaluated involving the anti-inflammatory and inhibitory potencies on AChE, BChE, and Aβ aggregation. Compound 4 revealed the potent effect on inhibiting Aβ aggregation activity with IC50 value of 33.1 μM, AChE activity with IC50 value of 6...
February 6, 2024: Chemistry & Biodiversity
https://read.qxmd.com/read/38267439/comparative-study-of-nio-cuo-ag-doped-graphene-based-materials-for-reduction-of-nitroaromatic-compounds-and-degradation-of-dye-with-statistical-study
#2
JOURNAL ARTICLE
Gayatri Pandey, Nidhi Singh, Nitesh Rajput, Mahesh Kumar Saini, S L Kothari, Jagdish Prasad, Narendra Pal Lamba, Manmohan Singh Chauhan
In the present work, the Nickel oxide (rGO-NiO), Silver (rGO-Ag), Copper oxide (rGO-CuO) doped Graphene Oxide are reported for catalytic reactions. A comparative study for catalytic activities of these materials are performed with nitroaromatic compound 4-nitroaniline and the results are statistically studied by using univariate analysis of variance and Post Hoc Test through Statistical Package for Social Sciences and it is observed that CuO doped Graphene material is showing better catalytic activity in minimum time...
January 24, 2024: Scientific Reports
https://read.qxmd.com/read/37871321/rational-design-of-bioorthogonally-activatable-protac-for-tumor-targeted-protein-degradation
#3
JOURNAL ARTICLE
Tao Bi, Pan Liang, Yanan Zhou, Hong Wang, Rui Huang, Qin Sun, Hongping Shen, Sijin Yang, Wei Ren, Zengjin Liu
Protein degradation mediated by the proteolysis-targeting chimera (PROTAC) has emerged as an efficient strategy to accurately control intracellular protein levels. However, the development of PROTACs is limited by their systemic toxicity. Herein, we report a bioorthogonally activatable prodrug (BT-PROTAC) strategy to accurately control the activity of PROTACs. As a proof of concept, we introduced the highly reactive trans -cyclooctene into PROTAC molecule MZ1, the structure-acitivity relationships of which were well characterized previously, to construct the bioorthogonally activatable prodrug BT-PROTAC...
October 23, 2023: Journal of Medicinal Chemistry
https://read.qxmd.com/read/37731517/cd47-blockade-enhances-phagocytosis-of-cardiac-cell-debris-by-neutrophils
#4
JOURNAL ARTICLE
Elias Haj-Yehia, Sebastian Korste, Robert Jochem, Aldona Lusha, Anna Roth, Nina Dietzel, Josefine Niroomand, Pia Stock, Astrid M Westendorf, Jan Buer, Ulrike B Hendgen-Cotta, Tienush Rassaf, Matthias Totzeck
CD47 is a cell surface protein controlling phagocytotic activity of innate immune cells. CD47 blockade was investigated as an immune checkpoint therapy in cancer treatment, enhancing phagocytosis of tumor cells by macrophages. Anti-CD47 treatment also reduced injury size during reperfused acute myocardial infarction (repAMI) by enhancing phagocytotic acitivity of macrophages. Little is known about the impact of CD47 blockade on neutrophils, representing the main portion of early infiltrating immune cells after repAMI...
October 2023: IJC Heart & Vasculature
https://read.qxmd.com/read/37602139/exercise-as-an-adjuvant-treatment-of-schizophrenia-a-review
#5
REVIEW
Muhammad S Abbas, Sondos T Nassar, Tasniem Tasha, Anjali Desai, Anjana Bajgain, Asna Ali, Chandrani Dutta, Khadija Pasha, Salomi Paul, Sathish Venugopal
Schizophrenia is a chronic debilitating condition associated with impaired social functioning, memory, and executive functioning. To date, we are still unsure about the exact etiology of schizophrenia, but there are many factors, such as genetics, diminished hippocampal volume, and imbalance of neurotransmitters, that lead to the pathogenies of the disease. Antipsychotics are the most effective treatment option for schizophrenia so far, yet they are associated with a wide array of side effects, ranging from extrapyramidal side effects to conditions, such as metabolic syndrome...
July 2023: Curēus
https://read.qxmd.com/read/37600464/effect-of-grape-seed-proanthocyanidin-on-the-structural-and-physicochemical-properties-of-bread-during-bread-fermentation-stage
#6
JOURNAL ARTICLE
Tong Jiang, Hong Wang, Peihua Xu, Yifan Yao, Yilong Ma, Zhaojun Wei, Xiangli Niu, Yafang Shang, Dong Zhao
Bread was prepared using wheat flour with grape seed proanthocyanidin (GSP) (0.4%). GSP improved the textural properties of bread including hardness, cohesiviness, gumminess and chewiness. At the last stage of fermentation, GSP reinforced the gluten microstructure with increased the disulfide bonds and hydrophobic interaction and α-helix in the secondary structures. Moreover, GSP addition could increase the total phenolics and antioxidative acitivity of the bread significantly. In addition, the degree of fermentation had a strong influence on the dough forces, and the reasonable control of bread fermentation time was beneficial to improve the bread quality, which provided a reference for the bread processing industry...
2023: Current research in food science
https://read.qxmd.com/read/37561940/design-build-test-of-synthetic-promoters-for-inducible-gene-regulation-in-alphaproteobacteria
#7
JOURNAL ARTICLE
Jonas Kretz, Vera Israel, Matthew McIntosh
Inducible gene expression is useful for biotechnological applications and for studying gene regulation and function in bacteria. Many inducible systems that perform in model organisms such as the Gammaproteobacterium Escherichia coli do not perform well in other bacteria that are of biotechnological interest. Typical problems include weak or leaky expression. Here, we describe an invention named ACIT (Alphaproteobacteria chromosomally integrating transcription-control cassette) that is carried on a suicide plasmid to enable insertion into the chromosome of the host...
August 10, 2023: ACS Synthetic Biology
https://read.qxmd.com/read/37507921/comparison-of-fungal-thermophilic-and-mesophilic-catalase-peroxidases-for-their-antioxidative-properties
#8
JOURNAL ARTICLE
Andrej Poljovka, Miloš Musil, David Bednář, Katarína Chovanová, Vladena Bauerová-Hlinková, Jana Bellová, Lenka Kohútová, Peter Baráth, Marcel Zámocký
Catalase-peroxidases (KatGs) are unique bifunctional oxidoreductases that contain heme in their active centers allowing both the peroxidatic and catalatic reaction modes. These originally bacterial enzymes are broadly distributed among various fungi allowing them to cope with reactive oxygen species present in the environment or inside the cells. We used various biophysical, biochemical, and bioinformatics methods to investigate differences between catalase-peroxidases originating in thermophilic and mesophilic fungi from different habitats...
July 4, 2023: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/37257697/lignan-glycosides-from-fritillaria-verticillata-willd-and-their-anti-inflammatory-activities
#9
JOURNAL ARTICLE
Nan Ma, Si-Xuan Liu, Yong-Fu Li, Fu-Hua Deng, Yi-Hui Yang, Chang Li, Yue-Hu Pei
Three undescribed lignan glycosides, echiunines E-G (1-3), as well as eight known compounds (4-11) were isolated from Fritillaria verticillata Willd. Among them, compounds 1-3 were a series of lignan glycosides reported for the first time from genus Fritillaria. Their structures were elucidated by analyses of extensive spectroscopic data and comparison of the NMR data with those reported previously, the absolute configuration of compounds were further confirmed by calculated ECD method. The NO release inhibitory effects of compounds were evaluated in LPS-activated RAW264...
May 29, 2023: Fitoterapia
https://read.qxmd.com/read/37026003/association-of-sars-cov-2-nucleocapsid-viral-antigen-and-the-receptor-for-advanced-glycation-end-products-with-development-of-severe-disease-in-patients-presenting-to-the-emergency-department-with-covid-19
#10
JOURNAL ARTICLE
Zachary A Matthay, Alexander T Fields, Katherine D Wick, Chayse Jones, H Clifford Lane, Kimberly Herrera, Brenda Nuñez-Garcia, Efstathios Gennatas, Carolyn M Hendrickson, Aaron E Kornblith, Michael A Matthay, Lucy Z Kornblith
INTRODUCTION: There remains a need to better identify patients at highest risk for developing severe Coronavirus Disease 2019 (COVID-19) as additional waves of the pandemic continue to impact hospital systems. We sought to characterize the association of receptor for advanced glycation end products (RAGE), SARS-CoV-2 nucleocapsid viral antigen, and a panel of thromboinflammatory biomarkers with development of severe disease in patients presenting to the emergency department with symptomatic COVID-19...
2023: Frontiers in Immunology
https://read.qxmd.com/read/36971209/extending-the-record-of-terpenes-from-soft-coral-sarcophyton-mililatensis
#11
JOURNAL ARTICLE
Min Yang, Zeng-Yue Ge, Zi-Hui Chen, Li-Gong Yao, Lin-Fu Liang, Yue-Wei Guo
In the present study, a new polyoxygenated cembranoid named sarcomililatol H (1) as well as six known terpenes 2 - 7 with different skeletons were isolated from South China Sea soft coral Sarcophyton mililatensis. Based on the comprehensive analyses of 1D and 2D NMR spectroscopic data, the structure of the new compound 1 was established. This new cembranoid was characterized by the presence of the rarely encountered tetrahydropyran ring with the ether linkage across C-2 and C-12. By applying the time-dependent density functional theory electronic circular dichroism (TDDFT ECD) approach, the absolute configuration of sarcomililatol H (1) was determined...
March 27, 2023: Chemistry & Biodiversity
https://read.qxmd.com/read/36829841/inversion-theory-leveling-as-a-new-methodological-approach-to-antioxidant-thermodynamics-a-case-study-on-phenol
#12
JOURNAL ARTICLE
Nikola Stamenković, Janez Cerkovnik, Nataša Poklar Ulrih
Antioxidants are various types of compounds that represent a link between biology and chemistry. With the development of theoretical and computational methods, antioxidants are now being studied theoretically. Here, a novel method is presented that aims to reduce the estimated wall times for DFT calculations that result in the same or higher degree of accuracy in the second derivatives over energy than is the case with the regular computational route (i.e., optimizing the reaction system at a lower model and then recalculating the energies at a higher level of theory) by applying the inversion of theory level to the universal chemical scavenger model, i...
January 27, 2023: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/36762881/medical-student-interest-and-participation-in-research-at-one-rural-clinical-school-insights-from-the-last-six-years
#13
JOURNAL ARTICLE
Jordan L Fox, Jacky Cribb, Kaye Cumming, Priya Martin
INTRODUCTION: Limited evidence is currently available relating to research acitivity of medical students training in regional or rural areas. OBJECTIVE: To describe medical student interest and participation in research at The University of Queensland Rural Clinical School (UQRCS). DESIGN: Annual student expression of interest surveys were collated with records of student research participation maintained at UQRCS from 2017-2022. Additionally, a systematic search was conducted to identify student outputs not captured in internal records...
February 10, 2023: Australian Journal of Rural Health
https://read.qxmd.com/read/36700506/traumatic-coagulopathy-in-the-older-patient-analysis-of-coagulation-profiles-from-the-activation-of-coagulation-and-inflammation-in-trauma-2-acit-2-observational-multicenter-study
#14
JOURNAL ARTICLE
Nicola S Curry, Ross Davenport, Henna Wong, Christine Gaarder, Pär Johansson, Nicole P Juffermans, Marc Maegele, Jakob Stensballe, Karim Brohi, Mike Laffan, Simon J Stanworth
BACKGROUND: Most studies describing traumatic coagulopathy have used data from patient cohorts with an average age of between 35 and 45 years. The last 10 years has seen a steep increase in the number of patients admitted with significant injury and bleeding who are older than the age of 65 years. Many coagulation protein levels alter significantly with normal aging, and it is possible that traumatic coagulopathy has a different signature with age. OBJECTIVES: The aim of this study was to report the coagulation profiles, including standard and extended laboratory, as well as viscoelastic hemostatic assays, stratified according to age to explore age-related differences in hemostatic capability...
December 15, 2022: Journal of Thrombosis and Haemostasis: JTH
https://read.qxmd.com/read/36598515/effect-of-rapamycin-treatment-in-human-seminoma-tcam-2-cells-through-inhibition-of-g1-s-transition
#15
JOURNAL ARTICLE
Tugce Onel, Cihan S Erdogan, Basak Aru, Ecem Yildirim, Gulderen Yanikkaya Demirel, Aylin Yaba
Mammalian target of rapamycin (mTOR) is an important serine/threonine kinase that plays a critical role in several processes including cell cycle, protein synthesis, and energy metabolism. Due to its multiple roles and general dysregulation in cancer, the mTOR pathway is an important target in cancer therapy. However, studies on mTOR activity in seminoma are limited. Therefore, our aim was to investigate the expression of mTOR signaling pathway proteins in the TCam-2 cell line after rapamycin treatment. TCam-2 cells were treated with different concentrations of rapamycin (control (no rapamycin treatment), 4 nM, 20 nM, 100 nM, 500 nM, and 1000 nM rapamycin) for 48 h and 72 h...
January 4, 2023: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/36570117/the-effects-of-exercise-on-coronary-collateral-circulation-a-review
#16
REVIEW
Robert Ambrogetti
The effects of exercise on the cardiovascular system are multifaceted and complex. It is well-documented that exercise can reduce mortality related to cardiovascular pathology. One anatomical structure that has been implicated in this process is the coronary collateral circulation. The goal of this review is to evaluate the current literature on the effects of exercise on human coronary collateral circulation. A search for literature was conducted on the databases Science Direct and PubMed using the terms: coronary collateral, collateral, exercise, physical activity, resistance training, endurance training, and collateral artery...
December 2022: Curēus
https://read.qxmd.com/read/36514858/cladiella-octocorals-%C3%A2-enormous-sources-of-secondary-metabolites-with-diverse-structural-and-biological-properties
#17
JOURNAL ARTICLE
Ye-Qing Du, Lin-Fu Liang, Yue-Wei Guo
Marine octocorals belonging to the genus Cladiella, usually encountered on reefs in the Indo-Pacific region, have been proven to be rich sources of diverse secondary metabolites with intriguing structural features and promising bioactivities. In this review, 155 compounds from six unambiguously identified C. krempfi, C. australis, C. pachyclados, C. hirsuta, C. tuberculosa, C. conifera, together with several unidentified Cladiella spp.are summarized covering the literatures from 2006 to August 2022. It is noteworthy that diterpenoids dominated the secondary metabolite profile of this genus counting for 78%...
December 13, 2022: Chemistry & Biodiversity
https://read.qxmd.com/read/36225374/isolation-and-characterization-of-phosphate-solubilizing-bacteria-naturally-colonizing-legumes-rhizosphere-in-morocco
#18
JOURNAL ARTICLE
Walid Janati, Karima Mikou, Lahsen El Ghadraoui, Faouzi Errachidi
Low-cost and environmentally friendly agricultural practices have received increasing attention in recent years. Developing microbial inoculants containing phosphate (P) solubilizing bacteria (PSB) represents an emerging biological solution to improve rhizosphere P availability. The present study aims to explore PSB strains isolated from soils located at different bioclimatic stages in Morocco and present in various legumes rhizosphere to improve agronomic microbial fertilizer's effectiveness. It was also aimed to test the isolated strains for their ability to solubilize P in NBRIP medium with Tricalcium P (Ca3 (PO4 )2 ) (TCP), rock phosphate (RP), and their combination as a source of phosphorus, by (22 ) experiment design...
2022: Frontiers in Microbiology
https://read.qxmd.com/read/36179984/photodissociation-of-nitric-oxide-from-designed-ruthenium-nitrosyl-complex-studies-on-wound-healing-and-antibacterial-activity
#19
JOURNAL ARTICLE
Sain Singh, Govinda R Navale, Mithil Mahale, Virendra Kumar Chaudhary, Kisan Kodam, Kaushik Ghosh
A photoactivable NO releasing complex [Ru(L1-2 )(PPh3 )(NO)Cl2 ](PF6 )(1a) have been synthesized by complex [RuL1-2 (PPh3 )2 Cl2 ](1). Newly designed bidentate ligands, i.e., 4-methoxy-N'-phenyl-N'-(pyridin-2-ylmethyl)benzohydrazide(L1 ) and 4-nitro-N'-phenyl-N'-(pyridin-2-ylmethyl)benzohydrazide (L2 ) were utilized to synthesize complex (1). Complex (1) was characterized by ESI-MS, and the solid structure of the complex [1a](PF6 ) was acquired by X-ray crystallography. Different spectroscopic techniques were employed for the identification of ligands (L1 and L2 ) and complexes (1 and [1a](PF6 ))...
September 27, 2022: Nitric Oxide: Biology and Chemistry
https://read.qxmd.com/read/36106739/-the-healthcare-system-plays-a-key-role-in-promoting-physical-acitivity
#20
JOURNAL ARTICLE
Maria Hagströmer, Carl Johan Sundberg, Matti Leijon, Ulf Eriksson, Ing-Mari Dohrn
Physical inactivity is recognised as a major public health problem. In Sweden about 1/3 of the adult population reports being insufficiently active. A central task in public health work is to support the individual, without blaming, in making healthy choices. Initiatives in healthcare, such as counselling on physical activity, have been shown to be both cost-effective and effective for disease prevention and treatment. The use of a physical activity vital sign and brief advice from physicians can make a big difference...
September 14, 2022: Läkartidningen
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