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https://www.readbyqxmd.com/read/27927192/daily-milk-consumption-and-all-cause-mortality-coronary-heart-disease-and-stroke-a-systematic-review-and-meta-analysis-of-observational-cohort-studies
#1
Patrick Mullie, Cécile Pizot, Philippe Autier
BACKGROUND: Observational studies and meta-analyses relating milk consumption by adults to all-cause mortality, coronary heart disease and stroke have obtained contradictory results. Some studies found a protective effect of milk consumption, whilst other found an increased risk. METHODS: We performed a systematic literature search until June 2015 on prospective studies that looked at milk consumption, all-cause mortality, coronary heart disease and stroke. Random-effect meta-analyses were performed with dose-response...
December 8, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27917709/synthesis-of-some-steroidal-derivatives-with-side-chain-of-20-and-22-hydrazone-aromatic-heterocycles-and-their-antiproliferative-acitivity
#2
Chunfang Gan, Liang Liu, Jianguo Cui, Zhiping Liu, Haixin Shi, Qifu Lin, Haibing Sheng, Chunhui Yang, Yanmin Huang
BACKGROUND: The modification of steroidal structure is commonly used to change the biological activity of steroids in medicinal chemistry. Some steroids containing heterocycles exhibit distinct cytotoxicity against various cancer cell lines and have been gotten wide attention over the years by medicinal chemists for drug discovery. METHODS: Using pregnenolone and stigmasterol as starting materials, via different chemical reaction, two series of heterosteroids with side chain of 20- and 22-hydrazone aromatic cycles or heterocycles in their structures were synthesized and characterized by IR, NMR and HRMS...
December 5, 2016: Medicinal Chemistry
https://www.readbyqxmd.com/read/27875779/novel-pyrimidine-2-4-dione-1-2-3-triazole-and-furo-2-3-d-pyrimidine-2-one-1-2-3-triazole-hybrids-as-potential-anti-cancer-agents-synthesis-computational-and-x-ray-analysis-and-biological-evaluation
#3
Tomislav Gregorić, Mirela Sedić, Petra Grbčić, Andrea Tomljenović Paravić, Sandra Kraljević Pavelić, Mario Cetina, Robert Vianello, Silvana Raić-Malić
Regioselective 1,4-disubstituted 1,2,3-triazole tethered pyrimidine-2,4-dione derivatives (5-23) were successfully prepared by the copper(I)-catalyzed click chemistry. While known palladium/copper-cocatalyzed method based on Sonogashira cross-coupling followed by the intramolecular 5-endo-dig ring closure generated novel 6-alkylfuro[2,3-d]pyrimidine-2-one-1,2,3-triazole hybrids (24b-37b), a small library of their 5-alkylethynyl analogs (24a-37a) was synthesized and described for the first time by tandem terminal alkyne dimerization and subsequent 5-endo-trig cyclization, which was additionally corroborated with computational and X-ray crystal structure analyses...
January 5, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27807327/hyperuricemia-is-an-independent-risk-factor-for-%C3%A2-renal-pathological-damage-and-poor-prognosis-in-%C3%A2-lupus-nephritis-patients
#4
Tingting Xie, Mengying Chen, Xiangling Tang, Hongling Yin, Xuan Wang, Guoli Li, Jiarong Li, Xiaoxia Zuo, Weiru Zhang
To explore the correlation between hyperuricemia and renal damage in patients with lupus nephritis (LN).
 Methods: The data for clinical features, laboratory and renal pathological examination were collected from 177 renal biopsy-proven LN patients with or without hyperuricemia and were retrospectively analyzed to determine the correlation between serum uric acid and renal damage.
 Results: LN patients with hyperuricemia group had higher rate of hypertension and higher level of blood urea nitrogen and serum creatinine while lower estimated glomerular filtration rate (eGFR) and lower positive rate of anti-U1RNP antibody (P<0...
October 28, 2016: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/27748477/a-highly-efficient-g-c3n4-sio2-heterojunction-the-role-of-sio2-in-the-enhancement-of-visible-light-photocatalytic-activity
#5
Qiang Hao, Xiuxiu Niu, Changshun Nie, Simeng Hao, Wei Zou, Jiangman Ge, Daimei Chen, Wenqing Yao
SiO2, an insulator, hardly has any photocatalytic acitivity due to its intrinsic property, and it is generally used as a hard template to increase the surface area of catalysts. However, in this work, we found that the surface state of the insulator SiO2 can promote the migration of photogenerated charge carriers, leading to the enhancement of the photooxidation ability of graphitic carbon nitride (g-C3N4). A one-pot calcination method was employed to prepare g-C3N4/SiO2 composites using melamine and SiO2 as precursors...
October 17, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27679435/biological-variation-of-hemostasis-variables-in-thrombosis-and-bleeding-consequences-for-performance-specifications
#6
Moniek P M de Maat, Marianne van Schie, Cornelis Kluft, Frank W G Leebeek, Piet Meijer
BACKGROUND: Levels of hemostasis factors vary between and within individuals as a result of genetic and environmental factors and analytical variation of the assays. The current state of the art for defining analytical precision requirements for analytical testing is based on this between- and within-individual (biological) variation. However, information on biological variation in hemostasis variables is still limited.The aim of this study was to determine the biological variation of coagulation variables involved in thrombosis and bleeding to provide a recommendation for performance specifications and to assess whether hemostasis assays fulfill the recommendation...
December 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27572414/cefazolin-and-ertapenem-a-synergistic-combination-used-to-clear-persistent-staphylococcus-aureus-bacteremia
#7
George Sakoulas, Joshua Olson, Juwon Yim, Niedita B Singh, Monika Kumaraswamy, Diana T Quach, Michael J Rybak, Joseph Pogliano, Victor Nizet
BACKGROUND: Ertapenem and cefazolin were used in combination to successfully clear refractory methicillin-susceptible Staphylcoccus aureus (MSSA) bacteremia. In addition, recent work has demonstrated acitivity of combination beta-lactam therapy from different classes against MRSA. METHODS: Ertapenem plus cefazolin combination was evaluated for synergy in vitro and in vivo in a murine skin infection model using an index MSSA bloodstream isolate from a patient in whom persistent bacteremia was cleared with this combination, and against a cadre of well-described research strains and clinical strains of MSSA and MRSA...
August 29, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27556817/hepatocyte-growth-factor-modified-mesenchymal-stem-cells-improve-ischemia-reperfusion-induced-acute-lung-injury-in-rats
#8
S Chen, X Chen, X Wu, S Wei, W Han, J Lin, M Kang, L Chen
Accumulative evidence demonstrated that mesenchymal stem cell (MSC) engraftment could protect tissue injury from ischemia/reperfusion (I/R). Hepatocyte growth factor (HGF) has important roles in the cell and tissue repairment and regeneration. Here we investigated the enhanced effects of HGF-modified MSCs on I/R-induced acute lung injury. Rat bone marrow-derived MSCs were successfully transfected to express HGF. HGF modification did not affect the characteristics of MSCs, and increased MSC viability, and inhibit the proinflammatory phenotype of MSCs in the inflammatory condition...
September 22, 2016: Gene Therapy
https://www.readbyqxmd.com/read/27495771/inadequate-anti-oxidative-responses-in-kidneys-of-brain-dead-rats
#9
Dane Hoeksma, Rolando A Rebolledo, Christina M V Hottenrott, Yves S Bodar, Janneke J Wiersema-Buist, Harry van Goor, Henri G D Leuvenink
INTRODUCTION: Brain death (BD)-related lipid peroxidation, measured as serum malondialdehyde (MDA) levels, correlates with delayed graft function (DGF) in renal transplant recipients. How BD affects lipid peroxidation is not known. The extent of BD-induced organ damage is influenced by the speed at which intracranial pressure increases. To determine possible underlying causes of lipid peroxidation, we investigated the renal redox balance by assessing oxidative and anti-oxidative processes in kidneys of brain-dead rats after fast and slow BD induction...
August 5, 2016: Transplantation
https://www.readbyqxmd.com/read/27416319/three-enzyme-cascade-bioreactor-for-rapid-digestion-of-genomic-dna-into-single-nucleosides
#10
Junfa Yin, Tian Xu, Ning Zhang, Hailin Wang
Structure-based DNA modification analysis provides accurate and important information on genomic DNA changes from epigenetic modifications to various DNA lesions. However, genomic DNA strands are often required to be efficiently digested into single nucleosides. It is an arduous task because of the involvement of multiple enzymes with different catalytic acitivities. Here we constructed a three-enzyme cascade capillary monolithic bioreactor that consists of immobilized deoxyribonuclease I (DNase I), snake venom phosphodiesterase (SVP), and alkaline phosphatase (ALPase)...
August 2, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27315124/nonprofessional-phagocytosis-in-trophectoderm-cells-of-human-preimplantation-blastocysts
#11
Yan Li, Jian Xu, Can-Quan Zhou, Cui-Lian Zhang, Guang-Lun Zhuang
UNLABELLED: Trophoblast phagocytosis has been considered important in pregnancy. However, whether human preimplantation blastocysts possess phagocytic activity is still unclear. In this study, we determined the phagocytosis potential in human trophectoderm cells of blastocysts prior to implantation. Fluorescent microspheres were used as markers for phagocytic analysis under transmission electron microscope (TEM) and fluorescence microscopy. Phagocytosis of 1 μm fluorescent microspheres was observed in most (9/11) day-6 and even some (2/9) day-5 blastocysts...
August 2016: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/27311427/light-storing-photocatalyst-the-possibility-of-activating-titanium-dioxide-by-photoluminescence
#12
Stefano Cattini, Federica Bondioli
INTRODUCTION: The aim of the present work was to analyze the possibility of creating a light-storing photocatalyst material, a system that couples a phosphorescent substrate with a titania coating. The substrate could activate the titanium dioxide coating even in condition of darkness thanks to its light emission. This improvement of absorption can be achieved because the titania semiconductor is irradiated both by the direct light and by the luminescent substrate which is activated at the same time...
June 1, 2016: Journal of Applied Biomaterials & Functional Materials
https://www.readbyqxmd.com/read/27266668/2-2-fluorine-mono-carbonyl-curcumin-induce-reactive-oxygen-species-mediated-apoptosis-in-human-lung-cancer-nci-h460-cells
#13
Guo-Yun Liu, Qiang Zhai, Jia-Zhuang Chen, Zhuo-Qing Zhang, Jie Yang
In this paper, we synthesized three fluorine-substituted mono-carbonyl curcumin analogs and evaluated their cytotoxicity against several cancer cells by the MTT assay. The results exhibited that all the three compounds were more active than the leading curcumin. Especially, 2,2'-F mono-carbonyl curcumin, 1a, surfaced as an important lead compound displaying almost 4-fold cytotoxicity relative to curcumin. More importantly, 1a was more stable in (RPMI)-1640 medium and more massive uptake than curcumin, which may be relationship to their cytotoxicity, apoptotic acitivity and reactive oxygen species generation...
September 5, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27173101/origin-of-asymmetric-solvation-effects-for-ions-in-water-and-organic-solvents-investigated-using-molecular-dynamics-simulations-the-swain-acity-basity-scale-revisited
#14
Maria M Reif, Philippe H Hünenberger
The asymmetric solvation of ions can be defined as the tendency of a solvent to preferentially solvate anions over cations or cations over anions, at identical ionic charge magnitudes and effective sizes. Taking water as a reference, these effects are quantified experimentally for many solvents by the relative acity (A) and basity (B) parameters of the Swain scale. The goal of the present study is to investigate the asymmetric solvation of ions using molecular dynamics simulations, and to connect the results to this empirical scale...
August 25, 2016: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/27044348/insights-into-the-structure-function-relationship-of-brugia-malayi-thymidylate-kinase-bmtmk
#15
Pawan Kumar Doharey, Sudhir Kumar Singh, Pravesh Verma, Anita Verma, Sushma Rathaur, Jitendra Kumar Saxena
Lymphatic filariasis is a debilitating disease caused by lymph dwelling nematodal parasites like Wuchereria bancrofti, Brugia malayi and Brugia timori. Thymidylate kinase of B. malayi is a key enzyme in the de novo and salvage pathways for thymidine 5'-triphosphate (dTTP) synthesis. Therefore, B. malayi thymidylate kinase (BmTMK) is an essential enzyme for DNA biosynthesis and an important drug target to rein in filariasis. In the present study, the structural and functional changes associated with recombinant BmTMK, in the presence of protein denaturant GdnHCl, urea and pH were studied...
July 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/26889186/exogenous-nerve-growth-factor-protects-the-hypoglossal-nerve-against-crush-injury
#16
Li-Yuan Fan, Zhong-Chao Wang, Pin Wang, Yu-Yan Lan, Ling Tu
Studies have shown that sensory nerve damage can activate the p38 mitogen-activated protein kinase (MAPK) pathway, but whether the same type of nerve injury after exercise activates the p38MAPK pathway remains unclear. Several studies have demonstrated that nerve growth factor may play a role in the repair process after peripheral nerve injury, but there has been little research focusing on the hypoglossal nerve injury and repair. In this study, we designed and established rat models of hypoglossal nerve crush injury and gave intraperitoneal injections of exogenous nerve growth factor to rats for 14 days...
December 2015: Neural Regeneration Research
https://www.readbyqxmd.com/read/26711240/discovery-of-multi-target-anticancer-agents-based-on-hdac-inhibitor-ms-275-and-5-fu
#17
Yuqi Jiang, Xiaoguang Li, Xiaoyang Li, Jinning Hou, Yongzheng Ding, Jian Zhang, Wenfang Xu, Yingjie Zhang
Histone deacetylases (HDACs) inhibitors have multiple effects targeting the cancer cells and have become one of the promising cancer therapeutics with possibly broad applicability. Combination of HDAC inhibitors with the cytotoxic fluorouracil (5-FU) showed additive and synergistic effects both in vitro and in vivo. To explore the possibility in cancer therapy of a bivalent agent that combines two bioactive groups within a single molecular architecture, we designed and synthesized new dual-acting compounds by combining the bioactive fragment of MS-275, a clinical HDACs inhibitor, with cytotoxic agent 5-FU...
2016: Medicinal Chemistry
https://www.readbyqxmd.com/read/26581314/pharmacokinetics-and-systemic-activity-of-a-new-patent-of-an-inhaled-corticosteroid-long-acting-%C3%AE-2-agonist-combination-for-use-in-asthma-therapy-fluticasone-furoate-vilanterol-trifenatate
#18
Ole D Wolthers
The present paper reviews pharmacokinetics and systemic activity of a new patent of fluticasone fumarate/vilanterol trifenatate and summarises the efficacy data in children, adolescents and adults with asthma. Bioavailability of oral deposition of fluticasone furoate is approximately 1%, of oral and pulmonary deposition 15%. Fluticasone furoate 400, 600 and 800 µg have been associated with reductions in 24h urine cortisol excretion in adults, whereas several studies on fluticasone furoate/ vilanterol trifenatate 100/25 µg and 200/25 µg once daily found no suppressive effects...
2015: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/26510371/-effect-of-clinical-pathway-on-advanced-schistosomiasis-patients-with-acites-a-report-of-220-cases
#19
Hong-bao Liao
OBJECTIVE: To evaluate the effect of the clinical pathway on advanced schistosomiasis patients with acites. METHODS: According to the Handbook of Schistosomiasis Control, and the Clinical Pathway on Advanced Schistosomiasis in Hubei Province, the therapeutic effects, disease awareness, and the satisfaction of patients of 220 advanced schistosomiasis patients (ascitic type) who were treated by the traditional pathway in 2013 and 220 patients who treated by the clinical pathway in 2014, respectively, were evaluated and compared with the statistical method...
June 2015: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
https://www.readbyqxmd.com/read/26440548/mri-and-thallium-features-of-pigmented-villonodular-synovitis-and-giant-cell-tumours-of-tendon-sheaths-a-retrospective-single-centre-study-of-imaging-and-literature-review
#20
REVIEW
Samuel J Lynskey, Marcus J Pianta
OBJECTIVE: The purpose of this study was to characterize the MRI and thallium-201 ((201)TI) scintigraphy attributes of pigmented villonodular synovitis (PVNS) and giant cell tumours of tendon sheaths (GCTTS). The epidemiology of these uncommon lesions was also assessed and less commonly encountered pathology reported on including multifocality, necrosis and concurrent malignancy. METHODS: A retrospective single centre review of MRI and (201)TI scintigraphy findings for 83 surgically proven or biopsy-proven consecutive cases of PVNS was undertaken...
2015: British Journal of Radiology
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