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https://www.readbyqxmd.com/read/28432268/clinical-outcomes-after-delayed-thyroid-surgery-in-patients-with-papillary-thyroid-microcarcinoma
#1
Min Ji Jeon, Won Gu Kim, Hyemi Kwon, Mijin Kim, Suyeon Park, Hye-Seon Oh, Minkyu Han, Tae-Yon Sung, Ki-Wook Chung, Suck Joon Hong, Tae Yong Kim, Young-Kee Shong, Won Bae Kim
OBJECTIVE: Active surveillance is an option for patients with papillary thyroid microcarcinoma (PTMC). However, the long-term clinical outcomes after delayed surgery remain unclear. We compared the long-term clinical outcomes of PTMC patients according to the time interval between initial diagnosis and surgery. DESIGN & METHODS: In this individual risk factor-matched cohort study, PTMC patients were classified into three groups according to the delay period: ≤ 6 months, 6-12 months, and > 12 months...
April 21, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28431609/benefit-risk-perception-of-natalizumab-therapy-in-neurologists-and-a-large-cohort-of-multiple-sclerosis-patients
#2
Christoph Heesen, Ingo Kleiter, Sven G Meuth, Julia Krämer, Jürgen Kasper, Sascha Köpke, Wolfgang Gaissmaier
BACKGROUND: Natalizumab (NAT) is associated with the risk of progressive multifocal leukoencephalopathy (PML). Risk stratification algorithms have been developed, however, without detectable reduction of PML incidence. OBJECTIVE: To evaluate to which extent patients and physicians understand and accept risks associated with NAT treatment. METHODS: Prospective observational cohort study in German MS centers (n=73) among NAT-treated MS patients (n=801) and their neurologists (n=99)...
May 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28431188/t-cell-receptor-%C3%AE-chain-repertoire-analysis-reveals-the-association-between-neoantigens-and-tumour-infiltrating-lymphocytes-in-multifocal-papillary-thyroid-carcinoma
#3
Zheming Lu, Chaoting Zhang, Jindong Sheng, Jing Shen, Baoguo Liu
To explore whether a few non-synonymous somatic mutations could induce activation and proliferation of neoantigen-specific tumour-infiltrating lymphocytes (TILs) in tumours with low mutation rates, we analysed a patient with multifocal papillary thyroid carcinoma (seven non-contiguous cancer foci) to investigate the relationship between neoantigens and TILs. These seven foci had a few or no non-synonymous somatic mutations; moreover, multiple loci had similar or different spectra of mutations. We used high-throughput sequencing of the rearranged genes in T cell receptor β-chain (TCRβ) to reveal the basic characteristics of T cells in seven tumour foci and matched adjacent normal tissue...
April 21, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28430336/an-italian-translation-and-validation-of-the-near-activity-visual-questionnaire-navq
#4
Fabrizio Zeri, Isabella Beltramo, Laura Boccardo, Paolo Palumbo, Vincenzo Petitti, James S Wolffsohn, Shehzad A Naroo
PURPOSE: To validate the Near Activity Vision Questionnaire (NAVQ) in Italian to allow the assessment of presbyopia corrections in Italian-speaking patients. METHODS: An Italian version of the NAVQ was arranged through several steps: an initial forward translation (from English to Italian), a backward translation (from Italian to English), and finally a consensual version to check against the original NAVQ. This prospective study enrolled native Italian-speaking presbyopic patients with corrected distance visual acuity of 0...
April 11, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28429818/piscirickettsia-salmonis-infection-in-cultured-lumpfish-cyclopterus-lumpus-l
#5
M Marcos-López, N M Ruane, F Scholz, M Bolton-Warberg, S O Mitchell, S Murphy O'Sullivan, A Irwin Moore, H D Rodger
A Piscirickettsia salmonis infection was diagnosed in lumpfish (Cyclopterus lumpus L.) juveniles held in a marine research facility on the west coast of Ireland. The main clinical signs and pathology included marked ascites, severe multifocal liver necrosis and severe diffuse inflammation and necrosis of the exocrine pancreas and peri-pancreatic adipose tissue. Numerous Piscirickettsia-like organisms were observed by histopathology in the affected organs, and the bacterial species was characterized by molecular analysis...
April 21, 2017: Journal of Fish Diseases
https://www.readbyqxmd.com/read/28428906/tbc1d24-mutations-in-a-sibship-with-multifocal-polymyoclonus
#6
Adeline Ngoh, Jose Bras, Rita Guerreiro, Amy McTague, Joanne Ng, Esther Meyer, W Kling Chong, Stewart Boyd, Linda MacLellan, Martin Kirkpatrick, Manju A Kurian
BACKGROUND: Advances in molecular genetic technologies have improved our understanding of genetic causes of rare neurological disorders with features of myoclonus. CASE REPORT: A family with two affected siblings, presenting with multifocal polymyoclonus and neurodevelopmental delay, was recruited for whole-exome sequencing following unyielding diagnostic neurometabolic investigations. Compound heterozygous mutations in TBC1D24, a gene previously associated with various epilepsy phenotypes and hearing loss, were identified in both siblings...
2017: Tremor and Other Hyperkinetic Movements
https://www.readbyqxmd.com/read/28428206/current-and-emerging-therapies-in-multiple-sclerosis-implications-for-the-radiologist-part-2-surveillance-for-treatment-complications-and-disease-progression
#7
REVIEW
C McNamara, G Sugrue, B Murray, P J MacMahon
An understanding of the new generation of MS drugs in conjunction with the key role MR imaging plays in the detection of disease progression, opportunistic infections, and drug-related adverse effects is of vital importance to the neuroradiologist. Part 1 of this review outlined the current treatment options available for MS and examined the mechanisms of action of the various medications. It also covered specific complications associated with each form of therapy. Part 2, in turn deals with the subject of pharmacovigilance and the optimal frequency of MRI monitoring for each individual patient, depending on his or her unique risk profile...
April 20, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28427986/prognostic-implications-of-extent-of-resection-in-glioblastoma-analysis-from-a-large-database
#8
Daniel M Trifiletti, Clayton Alonso, Surbhi Grover, Camilo E Fadul, Jason P Sheehan, Timothy N Showalter
OBJECTIVE: To analyze the predictors for and clinical impact of gross total resection (GTR) in patients with glioblastoma (GBM). METHODS AND MATERIALS: The National Cancer Database was queried for patients with GBM diagnosed from 2004-2013 with known survival and extent of resection. Patients were grouped based on extent of resection into biopsy alone, subtotal resection (STR), and GTR. Univariable and multivariable (MVA) analyses were performed to investigate factors associated with the likelihood of GTR and overall survival (OS) following diagnosis...
April 17, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28427695/paraneoplastic-acute-disseminated-encephalomyelitis-associated-with-multiple-myeloma
#9
Lai Yin Law, Kanae Jennifer Nagao
We describe a man recently diagnosed with multiple myeloma who presented with progressive spastic paraparesis, encephalopathy and multifocal MRI lesions with haemorrhage. Brain histopathology was consistent with acute disseminated encephalomyelitis (ADEM) with no new clinicoradiological findings on follow-up. This case emphasises the growing paraneoplastic spectrum, including non-classical but treatable disorders such as ADEM.
April 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28425387/zebra-borne-neurotropic-equid-herpesvirus-1-meningoencephalitis-in-a-thomson-s-gazelle-eudorcas-thomsonii
#10
Kanako Sakaguchi, Kenneth Kim, Ingeborg Langohr, Annabel G Wise, Roger K Maes, Gordon Pirie, Tokuma Yanai, Mohie Haridy, Lorrie Gaschen, Fabio Del Piero
We describe the histopathologic, immunohistochemical, and molecular features of a case of meningoencephalitis in a Thomson's gazelle ( Eudorcas thomsonii) naturally infected with zebra-borne equid herpesvirus 1 (EHV-1) and the implications for the molecular detection of zebra-borne EHV-1. A 4-y-old female Thomson's gazelle was submitted for postmortem examination; no gross abnormalities were noted except for meningeal congestion. Microscopic evaluation demonstrated multifocal nonsuppurative meningoencephalitis with intranuclear eosinophilic and amphophilic inclusion bodies and EHV-9 antigen in neurons...
April 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28424285/equine-arteritis-virus-has-specific-tropism-for-stromal-cells-and-cd8-t-and-cd21-b-lymphocytes-but-not-glandular-epithelium-at-the-primary-site-of-persistent-infection-in-the-stallion-reproductive-tract
#11
Mariano Carossino, Alan T Loynachan, Igor F Canisso, R Frank Cook, Juliana R Campos, Bora Nam, Yun Young Go, Edward L Squires, Mats H T Troedsson, Thomas Swerczek, Fabio Del Piero, Ernest Bailey, Peter J Timoney, Udeni B R Balasuriya
Equine arteritis virus (EAV) has a global impact on the equine industry being the causative agent of equine viral arteritis (EVA), a respiratory, systemic, and reproductive disease of equids. A distinctive feature of EAV infection is that it establishes long-term persistent infection in 10 to 70% of infected stallions (carriers). In these stallions, EAV is only detectable in the reproductive tract and viral persistence occurs despite the presence of high serum neutralizing antibodies. Carrier stallions constitute the natural reservoir of the virus as they continuously shed EAV in their semen...
April 19, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28423988/tumor-collision-of-uterine-adenocarcinoma-and-leiomyosarcoma-in-a-goat
#12
Jenna C Dockweiler, Brieuc Cossic, Sean P McDonough, Susan L Fubini, Kayla M Le, Callum G Donnelly, Robert O Gilbert, Soon Hon Cheong
An aged mixed-breed goat doe was presented with a 9-mo history of serosanguineous vaginal discharge. Vaginal speculum examination revealed serosanguineous discharge but otherwise no abnormalities. Transrectal ultrasonography showed normal ovaries and multifocal cystic lesions within the uterus. Ovariohysterectomy was recommended because of a strong suspicion of neoplasia. Multiple, non-resectable masses were noted in and around the uterus intraoperatively, and euthanasia was elected. Autopsy revealed multiple masses within the uterus, cervix, and lung parenchyma...
April 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28423432/-clinical-and-pathological-prognostic-factors-for-the-long-term-survival-of-patients-with-pt1-renal-cell-carcinoma
#13
Johannes Breyer, Wolfgang Otto, Eva Maria Lausenmeyer, Stefan Denzinger, Ann-Kathrin Schwientek, Ludwig Ochs, Roman Mayr, Michael Gierth, Johannes Bründl, Maximilian Burger, Matthias Evert, Hans-Martin Fritsche, Christian Eichelberg
Introduction The incidence of renal cell carcinoma (RCC) has been increasing over the past few decades. Simultaneously, due to improved imaging, small renal masses at stage pT1 have been diagnosed more frequently. However, it is known that even small RCCs may recur and metastasize at a late point of time. This study aimed to identify easy-to-assess clinical and histopathological prognostic markers for long-term survival. Patients/Methods We performed a retrospective analysis of patients who underwent surgical treatment of a pT1 RCC in a single centre between 1993 and 2007...
April 19, 2017: Aktuelle Urologie
https://www.readbyqxmd.com/read/28423364/increased-expression-of-deleted-in-malignant-brain-tumors-dmbt1-gene-in-precancerous-gastric-lesions-findings-from-human-and-animal-studies
#14
Jone Garay, M Blanca Piazuelo, Lizbeth Lopez-Carrillo, Yelda A Leal, Sumana Majumdar, Li Li, Nataly Cruz-Rodriguez, Silvia J Serrano-Gomez, Carlos S Busso, Barbara G Schneider, Alberto G Delgado, Luis E Bravo, Angela M Crist, Stryder M Meadows, M Constanza Camargo, Keith T Wilson, Pelayo Correa, Jovanny Zabaleta
Helicobacter pylori infection triggers a cascade of inflammatory stages that may lead to the appearance of non-atrophic gastritis, multifocal atrophic, intestinal metaplasia, dysplasia, and cancer. Deleted in malignant brain tumors 1 (DMBT1) belongs to the group of secreted scavenger receptor cysteine-rich proteins and is considered to be involved in host defense by binding to pathogens. Initial studies showed its deletion and loss of expression in a variety of tumors but the role of this gene in tumor development is not completely understood...
April 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28420821/use-of-liothyronine-without-levothyroxine-in-the-treatment-of-mild-consumptive-hypothyroidism-caused-by-hepatic-hemangiomas
#15
Shinji Higuchi, Masaki Takagi, Yukihiro Hasegawa
There have been reports of the use of levothyroxine or levothyroxine plus liothyronine for consumptive hypothyroidism caused by hepatic hemangiomas. Administration of levothyroxine without liothyronine can be inadequate to maintain normal levels of both free T3 and free T4 in some patients. However, there is no report of treatment with liothyronine plus propranolol. We herein present a case in which we used liothyronine therapy for multifocal hepatic hemangiomas in a Japanese patient with low free T3 and normal free T4 levels...
April 18, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28420555/chemoembolization-for-hepatocellular-carcinoma-in-patients-with-extrahepatic-spread-prognostic-determinants-and-appropriate-candidates
#16
Enxin Wang, Lei Liu, Dongdong Xia, Wenjun Wang, Wei Bai, Qiuhe Wang, Jie Yuan, Xiaomei Li, Lei Zhang, Jing Niu, Zhanxin Yin, Jielai Xia, Hongwei Cai, Daiming Fan, Guohong Han
PURPOSE: To investigate treatment outcome, prognostic factors for overall survival, and appropriate candidates for transarterial chemoembolization among patients with hepatocellular carcinoma (HCC) and extrahepatic spread (EHS). MATERIALS AND METHODS: From January 2010 to June 2014, 111 consecutive patients with HCC and EHS treated by transarterial chemoembolization alone were evaluated. Factors associated with overall survival were evaluated using Cox regression analysis, and a scoring equation was established to subgroup patients with EHS...
April 15, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28419635/canine-histiocytic-sarcoma-presenting-as-a-target-lesion-on-brain-magnetic-resonance-imaging-and-as-a-solitary-pulmonary-mass
#17
Jill Hicks, Renee Barber, Bronwen Childs, Shannon Gm Kirejczyk, Elizabeth W Uhl
A 6-year-old spayed female miniature schnauzer presented with generalized seizures and progressive multifocal intracranial neurologic disease. Thoracic radiographs and computed tomography (CT) revealed a large solitary pulmonary mass within the right cranial lung lobe. On brain magnetic resonance imaging (MRI), a solitary intraparenchymal mass within the left piriform lobe had a "target" appearance on both pre- and postcontrast sequences. Cerebrospinal fluid was unremarkable and histopathology indicated both masses represented histiocytic sarcoma...
April 17, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/28419455/human-electrical-muscular-incapacitation-and-effects-on-qtc-interval
#18
John A Gibbons, Andrew J Mojica, Mark E Peele
Human Electrical Muscular Incapacitation (HEMI) is used to subdue combative individuals. Changes in cardiac electrical activity have been proposed as the cause of death in a small fraction of these individuals. The current study sought to determine whether changes in QTc interval occur after HEMI exposure. Twenty-four participants had EKG readings before a 5-second HEMI exposure and within 30 min after exposure. All subject EKGs were read by a data-blinded cardiac electrophysiologist who calculated a QT corrected (QTc) interval...
April 17, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28417857/nuclear-medicine-imaging-in-pediatric-infection-or-chronic-inflammatory-diseases
#19
REVIEW
Alberto Signore, Andor W J M Glaudemans, Olivier Gheysens, Chiara Lauri, Onofrio A Catalano
In this review article, we focus on the most recent applications of nuclear medicine techniques (mainly (99m)Tc/(111)In white blood cells (WBC) scan, [(18)F]-FDG-PET/CT, [(18)F]-FDG-PET/MRI, and (99m)Tc-IL-2 scintigraphy) in the study of children affected by peripheral bone osteomyelitis, fungal infections, inflammatory bowel diseases, and type 1 diabetes, owing to recent important published evidences of their role in the management of these diseases. For osteomyelitis in children, both bone scintigraphy and [(18)F]-FDG-PET have a major advantage of assessing the whole body in one imaging session to confirm or exclude multifocal involvement, whereas WBC scan has a limited role...
May 2017: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/28417621/inverse-relation-between-mxa-gene-expression-and-age-in-multiple-sclerosis-patients-reveals-a-gender-difference-in-response-to-interferon-therapy
#20
Mohammad Taheri, Mohammadreza Mirinezhad, Mir Davood Omrani, Elham Sajjadi, Hidetoshi Inoko, Arezou Sayad
Multiple sclerosis (MS) is an inflammatory, multifocal, immune-mediated disease of the central nervous system that women are at a higher risk to acquire than men. Myxovirus resistance protein A (MxA) is used as a predictive marker of bioactivity of interferon-beta (IFN-β) therapy in MS patients. This study was undertaken in west of Iran to investigate gender differences in the expression level of MxA in relapsing-remitting MS (RRMS) patients receiving IFN-β therapy, compared with untreated normal individuals...
February 2017: Iranian Journal of Allergy, Asthma, and Immunology
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