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https://www.readbyqxmd.com/read/29684328/visual-outcomes-after-implantation-of-a-segmental-refractive-multifocal-intraocular-lens-following-cataract-surgery
#1
Thomas Kohnen, Eva Hemkeppler, Michael Herzog, Sabrina Schönbrunn, Nina DeLorenzo, Kerstin Petermann, Myriam Böhm
PURPOSE: To evaluate visual outcomes with particular attention to intermediate visual acuity (VA), of a segmental refractive multifocal intraocular lens (IOL) with optimized depth of focus (DoF) DESIGN: Prospective, noncomparative case series. METHODS: Setting: Department of Ophthalmology, Goethe University, Frankfurt/Germany. PATIENT OR STUDY POPULATION: Fifty eyes (25 patients) were included. INCLUSION CRITERIA: bilateral cataract, age >45 years, corneal astigmatism ≤0...
April 20, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29684231/bilateral-multifocal-renal-masses-in-a-35-year-old-man-with-a-history-of-tuberous-sclerosis-complex
#2
Pranav Sharma, Allan Haynes
No abstract text is available yet for this article.
April 15, 2018: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/29683985/accommodative-behavior-of-young-eyes-wearing-multifocal-contact-lenses
#3
Basal H Altoaimi, Meznah S Almutairi, Pete S Kollbaum, Arthur Bradley
SIGNIFICANCE: The effectiveness of multifocal contact lenses (MFCLs) at slowing myopia progression may hinge on the accommodative behavior of young eyes fit with these presbyopic style lenses. Can they remove hyperopic defocus? Convergence accommodation as well as pupil size and the zonal geometry are likely to contribute to the final accommodative responses. PURPOSE: The aim of this study was to examine the accommodation behavior of young adult eyes wearing MFCLs and the effectiveness of these MFCLs at removing foveal hyperopic defocus when viewing near targets binocularly...
April 20, 2018: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/29682725/atopic-labial-pigmentation-a-new-diagnostic-feature-in-asian-patients-with-atopic-dermatitis
#4
In-Hye Kang, Ki-Heon Jeong, Mu-Hyoung Lee, Min-Kyung Shin
BACKGROUND: Pigmented lesions on the lips can be caused by physiological or pathological factors, along with exogenous or endogenous factors. Many patients with atopic dermatitis (AD) and labial pigmentation are seen in clinical practice. The aim of our study was to further explore the association of labial pigmentation and AD. METHODS: We performed a retrospective chart review of patients who visited the Department of Dermatology at Kyung Hee Medical Center, Seoul, Korea, from January 1 to December 31, 2016...
April 23, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29682547/jc-virus-dna-detection-is-associated-with-cd8-effector-accumulation-in-peripheral-blood-of-patients-with-multiple-sclerosis-under-natalizumab-treatment-independently-from-jc-virus-serostatus
#5
Maria A Zingaropoli, Marco Iannetta, Simona Pontecorvo, Elena Anzivino, Carla Prezioso, Donatella Maria Rodio, Manuela Morreale, Alessandra D'Abramo, Alessandra Oliva, Miriam Lichtner, Antonio Cortese, Marco Frontoni, Valeria Pietropaolo, Ada Francia, Claudio M Mastroianni, Vincenzo Vullo, Maria R Ciardi
Although natalizumab (anti- α 4 integrin) represents an effective therapy for relapsing remitting multiple sclerosis (RRMS), it is associated with an increased risk of developing progressive multifocal leukoencephalopathy (PML), caused by the polyomavirus JC (JCV). The aim of this study was to explore natalizumab-induced phenotypic changes in peripheral blood T-lymphocytes and their relationship with JCV reactivation. Forty-four patients affected by RRMS were enrolled. Blood and urine samples were classified according to natalizumab infusion number: 0 ( N 0), 1-12 ( N 12), 13-24 ( N 24), 25-36 ( N 36), and over 36 ( N > 36) infusions...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29682536/in-vivo-evaluation-of-short-term-performance-of-new-three-layer-collagen-based-vascular-graft-designed-for-low-flow-peripheral-vascular-reconstructions
#6
Tomas Grus, Lukas Lambert, Mikulas Mlcek, Hynek Chlup, Eva Honsova, Miroslav Spacek, Andrea Burgetova, Jaroslav Lindner
Aim: The aim of this study was to evaluate short-term patency of the new prosthetic graft and its structural changes after explantation. Methods: The study team developed a three-layer conduit composed of a scaffold made from polyester coated with collagen from the inner and outer side with an internal diameter of 6 mm. The conduit was implanted as a bilateral bypass to the carotid artery in 7 sheep and stenosis was created in selected animals. After a period of 161 days, the explants were evaluated as gross and microscopic specimens...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29682392/a-rare-case-of-multifocal-prostatic-blue-nevus
#7
Elias J Farran, Preston S Kerr, Christopher D Kosarek, Joseph Sonstein, Eduardo J Eyzaguirre
Prostatic blue nevus is a rare benign pathologic diagnosis most commonly diagnosed incidentally on many different types of prostate specimens. Blue nevus is the deposition of stromal melanin characterized by spindle cells within the fibromuscular stroma which stains positive for melanin-specific stains Fontana-Masson and S100 and stains negative for CD68, HMB45, and iron stains. We report the case of a multifocal and bilateral blue nevus in a 52-year-old Hispanic male who presented with an elevated prostate-specific antigen of 4...
2018: Case Reports in Urology
https://www.readbyqxmd.com/read/29682362/upfront-radiotherapy-with-concurrent-and-adjuvant-vismodegib-is-effective-and-well-tolerated-in-a-patient-with-advanced-multifocal-basal-cell-carcinoma
#8
Abigail I Franco, Gary Eastwick, Ramsay Farah, Marvin Heyboer, Mijung Lee, Paul Aridgides
We present a case report of a male with multifocal and extensive basal cell carcinoma. Due to extremely large size and deep tumor infiltration, he was not a surgical candidate. Combined modality treatment of fractionated radiation with concurrent vismodegib was chosen. Concurrent treatment was previously reported in the palliative and recurrent setting. This is the first case of concurrent vismodegib and radiation therapy for upfront definitive management. The patient experienced complete response in all treated lesions...
2018: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/29682133/autosomal-dominant-polycystic-kidney-disease-a-potential-mistake-in-the-interpretation-of-radioiodine-whole-body-scintigraphy
#9
Leila Kalhor
There are a few case reports of renal cysts demonstrating radioiodine uptake on scintigraphy. In this case, we report a 49-year-old man who had undergone total thyroidectomy and had been treated with radioiodine. After conventional levothyroxine withdrawal, the patient underwent thyroid remnant ablation by oral administration of 125 mci 131 I. Seven days later, post-therapy whole-body scan demonstrated thyroid remnant tissue and bilaterally multifocal radioiodine uptake in the upper abdomen. By ultrasonography and abdominal computed tomography scan, the iodine uptake was proven to be due to the accumulation of 131 I in bilateral polycystic kidney disease...
April 2018: Radiology Case Reports
https://www.readbyqxmd.com/read/29681791/a-rare-multifocal-pattern-of-type-2-autoimmune-pancreatitis-with-negative-igg4-a-potential-diagnostic-pitfall-that-may-mimic-multifocal-pancreatic-adenocarcinoma
#10
Partha Hota, Tejas Patel, Xiaofeng Zhao, Nirag Jhala, Omar Agosto
Autoimmune pancreatitis (AIP) is an increasingly recognized form of acute pancreatitis characterized by obstructive jaundice with a rapid and dramatic treatment response to steroid therapy. Recently, AIP has been divided into two distinct phenotypes: lymphoplasmocytic sclerosing pancreatitis AIP (type 1) and idiopathic duct-centric pancreatitis AIP (type 2); each of which have their own distinct demographics, diagnostic criteria, and histopathological features. We report, to the best of our knowledge, the first case of a multifocal pattern of type 2 AIP characterized with both CT and MR imaging...
January 2018: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/29680441/the-impact-of-surgery-on-survival-after-progression-of-glioblastoma-a-retrospective-cohort-analysis-of-a-contemporary-patient-population
#11
REVIEW
Rahul A Sastry, Ganesh M Shankar, Elizabeth R Gerstner, William T Curry
Despite updated management of glioblastoma (GB), progression is virtually inevitable. Previous data suggest a survival benefit from resection at progression; however, relatively few studies have evaluated the role of surgery in the context of contemporary GB treatment and widespread use of bevacizumab and chemotherapy. As such, the purpose of this study is to evaluate outcomes following surgical resection in patients with progressive GB since 2008. The records of all patients who underwent biopsy or resection of GB between January 1, 2008, and December 31, 2015, were retrospectively reviewed to identify 368 patients with progressive GB...
April 18, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29679616/early-detection-of-diabetic-retinopathy
#12
REVIEW
Hamid Safi, Sare Safi, Ali Hafezi-Moghadam, Hamid Ahmadieh
Diabetic retinopathy (DR) is a primary cause of visual impairment worldwide. Diabetes mellitus may be associated with ophthalmoscopically nonvisible neurovascular damage that progresses before the first clinical signs of DR appear. Reduction of the inner neuroretinal layer thickness on macular optical coherence tomography (OCT), reduced contrast sensitivity primarily at low spatial frequencies, abnormal results in color vision and microperimetry tests, and a prolonged implicit time recorded by multifocal electroretinography have been proposed for detection of early functional and nonvisible structural neuroretinal changes...
April 18, 2018: Survey of Ophthalmology
https://www.readbyqxmd.com/read/29679510/molecular-characteristics-of-multifocal-brain-histiocytic-sarcoma
#13
Florent Marguet, Nicolas Piton, Homa Adle-Biassette, Florence Renaud, Elodie Bohers, Thomas Boyer, Aline Zarea, Stéphane Derrey, Jean Christophe Sabourin, Annie Laquerrière
Histiocytic sarcoma (HS) is a very uncommon malignant proliferation accounting for less than 1% of all neoplasms of hematopoietic and lymphoid tissues. According to the 2008 WHO classification of haematological and lymphoid tumours, diagnosis of HS requires histological and immunohistochemical evidence of histiocytic differentiation [1]. The 2016 Central nervous system (CNS) WHO classification parallels the categories of the corresponding WHO classification of hematopoietic and lymphoid tissues. By definition, diagnosis of HS relies on the expression of at least two of the histiocytic markers, e...
April 21, 2018: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/29679353/low-frequency-of-cervicocranial-artery-involvement-in-japanese-with-renal-artery-fibromuscular-dysplasia-compared-with-that-of-caucasians
#14
Eikan Mishima, Shu Umezawa, Takehiro Suzuki, Miki Fujimura, Michiaki Abe, Junichiro Hashimoto, Takaaki Abe, Sadayoshi Ito
BACKGROUND: Fibromuscular dysplasia (FMD), which usually affects the renal artery, also affects the carotid, vertebral, and intracranial arteries. Previous studies have shown a high prevalence of concomitant renal artery and cervicocranial lesions in FMD patients. However, the analyzed subjects were mostly Caucasians in Western countries. METHOD: We performed a retrospective analysis to examine the prevalence of cervicocranial vascular lesions in Japanese FMD patients with renal artery involvement at a single institution...
April 20, 2018: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29678430/osseous-rosai-dorfman-disease-presenting-as-a-solitary-lesion-of-the-distal-radius
#15
Amit Parekh, Feroz Osmani, Nathan Aardsma, John Groth, Mark Gonzalez
Rosai-Dorfman disease, also known as sinus histiocytosis with massive lymphadenopathy, is a rare entity in which bone involvement occurs in less than 5% to 10% of patients and skeletal cases are usually multifocal. Extranodal solitary lesions of bone without nodal involvement or additional clinical manifestations are exceedingly rare. We present the clinical course and management of a 34-year-old African American woman who presented with the disease as a solitary lesion of the distal radius.
April 17, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29677370/topical-ripasudil-suppresses-retinal-ganglion-cell-death-in-a-mouse-model-of-normal-tension-glaucoma
#16
Kei Akaiwa, Kazuhiko Namekata, Yuriko Azuchi, Hiroki Sano, Xiaoli Guo, Atsuko Kimura, Chikako Harada, Yoshinori Mitamura, Takayuki Harada
Purpose: To assess if ripasudil has a neuroprotective effect using mice with excitatory amino acid carrier 1 (EAAC1) deletion (EAAC1 knockout [KO] mice), a mouse model of normal tension glaucoma. Methods: Topical administration (5 μL/day) of two different concentrations of ripasudil (0.4% and 2%) were applied to EAAC1 KO mice from 5 to 12 weeks old. Optical coherence tomography, multifocal electroretinograms, the measurement of intraocular pressure (IOP), and histopathology analyses were performed at 5, 8, and 12 weeks old...
April 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29677357/optical-coherence-tomography-minimum-intensity-as-an-objective-measure-for-the-detection-of-hydroxychloroquine-toxicity
#17
Ali M Allahdina, Paul F Stetson, Susan Vitale, Wai T Wong, Emily Y Chew, Fredrick L Ferris Iii, Paul A Sieving, Catherine Cukras
Purpose: As optical coherence tomography (OCT) minimum intensity (MI) analysis provides a quantitative assessment of changes in the outer nuclear layer (ONL), we evaluated the ability of OCT-MI analysis to detect hydroxychloroquine toxicity. Methods: Fifty-seven predominantly female participants (91.2% female; mean age, 55.7 ± 10.4 years; mean time on hydroxychloroquine, 15.0 ± 7.5 years) were enrolled in a case-control study and categorized into affected (i.e...
April 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29677200/empirical-mode-decomposition-processing-to-improve-multifocal-visual-evoked-potential-signal-analysis-in-multiple-sclerosis
#18
Luis de Santiago, Eva Sánchez-Morla, Román Blanco, Juan Manuel Miguel, Carlos Amo, Miguel Ortiz Del Castillo, Almudena López, Luciano Boquete
OBJECTIVE: To study the performance of multifocal-visual-evoked-potential (mfVEP) signals filtered using empirical mode decomposition (EMD) in discriminating, based on amplitude, between control and multiple sclerosis (MS) patient groups, and to reduce variability in interocular latency in control subjects. METHODS: MfVEP signals were obtained from controls, clinically definitive MS and MS-risk progression patients (radiologically isolated syndrome (RIS) and clinically isolated syndrome (CIS))...
2018: PloS One
https://www.readbyqxmd.com/read/29676688/ophthalmic-manifestations-of-heimler-syndrome-due-to-pex6-mutations
#19
Nutsuchar Wangtiraumnuay, Waleed Abed Alnabi, Mai Tsukikawa, Avrey Thau, Jenina Capasso, Reuven Sharony, Chris F Inglehearn, Alex V Levin
BACKGROUND/AIMS: Pigmentary retinal dystrophy and macular dystrophy have been previously reported in Heimler syndrome due to mutations in PEX1. Here we reported the ocular manifestations in Heimler syndrome due to mutations in PEX6. MATERIALS AND METHODS: Medical records were reviewed to identify patient demographics, ophthalmic and systemic findings, and results of diagnostic testing including whole genome sequencing. RESULTS: Patient 1 is 12-year-old boy with a novel mutation c...
June 2018: Ophthalmic Genetics
https://www.readbyqxmd.com/read/29675590/oncological-outcomes-of-ibd-associated-versus-sporadic-colorectal-cancer-in-modern-era-a-matched-case-control-study
#20
Antoine Thicoïpé, David Laharie, Denis Smith, Edouard Chabrun, Anne Rullier, Florian Poullenot, Eric Rullier, Quentin Denost
AIM: Inflammatory bowel diseases (IBD) are associated with an increased risk for colorectal cancer (CRC). However and despite significant advances in the management of IBD and CRC, the prognosis of IBD-related CRC (IBD-CRC) remains controversial. The aim of the present case-control study was to compare the prognosis of IBD-CRC to sporadic CRC. METHODS: Consecutive patients operated for IBD-CRC from 2004 to 2014 were recruited and matched with sporadic CRC (ratio 3:1) from the same center...
April 19, 2018: International Journal of Colorectal Disease
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