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https://www.readbyqxmd.com/read/28922188/new-insights-into-the-role-of-glycosylation-in-lipoprotein-metabolism
#1
Marjolein A W van den Boogert, Daniel J Rader, Adriaan G Holleboom
PURPOSE OF REVIEW: Human genetics has provided new insights into the role of protein glycosylation in regulating lipoprotein metabolism. Here we review these new developments and discuss the biological insights they provide. RECENT FINDINGS: Case descriptions of patients with congenital defects in N-glycosylation (CDG-I) frequently describe a distinct hypocholesterolemia in these rare multisystem clinical syndromes. Two novel CDGs with disturbed Golgi homeostasis and trafficking defects result in mixed glycosylation disorders, hepatic steatosis and hypercholesterolemia...
September 15, 2017: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/28922149/the-relationships-between-components-of-metabolic-syndrome-and-mild-cognitive-impairment-subtypes-a-cross-sectional-study-of-japanese-older-adults
#2
Seongryu Bae, Hiroyuki Shimada, Sangyoon Lee, Hyuma Makizako, Sungchul Lee, Kazuhiro Harada, Takehiko Doi, Kota Tsutsumimoto, Ryo Hotta, Sho Nakakubo, Hyuntae Park, Takao Suzuki
BACKGROUND: The associations between components of metabolic syndrome (MetS) and mild cognitive impairment (MCI) subtypes remain unclear. OBJECTIVE: The study aim was to identify the prevalence of MetS for MCI subtypes and to investigate sex differences in the association between MetS and MCI subtypes in older Japanese adults. METHODS: The study analyzed data from 3,312 men and women aged 70 years or more. MetS was diagnosed according to International Diabetes Federation criteria...
September 8, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28922099/the-effects-of-probiotic-supplementation-on-gene-expression-related-to-inflammation-insulin-and-lipids-in-patients-with-multiple-sclerosis-a-randomized-double-blind-placebo-controlled-trial
#3
Omid Reza Tamtaji, Ebrahim Kouchaki, Mahmoud Salami, Esmat Aghadavod, Elmira Akbari, Maryam Tajabadi-Ebrahimi, Zatollah Asemi
BACKGROUND: Limited data are available assessing the effects of probiotic supplementation on gene expression related to inflammation, insulin, and lipids in patients with multiple sclerosis (MS). OBJECTIVES: The current study was conducted to assess the effects of probiotic supplementation on gene expression related to inflammation, insulin, and lipids in patients with MS. METHODS: This randomized, double-blind, placebo-controlled clinical trial was performed among 40 patients with MS...
September 18, 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28922043/association-between-triglyceride-high-density-lipoprotein-ratio-and-hearing-impairment-in-a-korean-population
#4
Da Jung Jung, Jun Young Do, Kyu Hyang Cho, A Young Kim, Seok Hui Kang
OBJECTIVE: The aim of the present study was to evaluate the clinical association between triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) ratio and hearing impairment in a Korean population. PATIENTS AND METHODS: This was a cross-sectional study (n=18,004). Participants were divided into 4 quartiles based on their TG/HDL-C ratio: first quartile (1Q), second quartile (2Q), third quartile (3Q), and fourth quartile (4Q). The threshold values at 0.5, 1, and 2 kHz were averaged to obtain the low- or mid-frequency pure-tone average (Low/Mid-Freq), and the values at 3, 4, and 6 kHz were averaged to obtain the high-frequency pure-tone average (High-Freq)...
September 18, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/28921768/microrna-326-3p-ameliorates-high-glucose-and-ox-ldl-ic-induced-fibrotic-injury-in-renal-mesangial-cells-by-targeting-fc%C3%AE-riii
#5
Yiting Wang, Rui Zhang, Junlin Zhang, Fang Liu
AIM: To identify the regulatory relationship between miR-326-3p and FcγRIII, and to explore the involvement of miR-326-3p/FcγRIII/TGF-β/Smad signaling pathway in fibrotic injury, which was induced by the high glucose (HG) and oxidized low density lipoprotein immune complex (ox-LDL-IC) in mouse glomerular mesangial cells (GMCs) METHODS: Dual-luciferase reporter system and real time PCR (RT-PCR) were used to identify FcγRIII as a target gene of miR-326-3p. Lentiviral transduction was utilized to construct different expression of miR-326-3p in GMCs, which were divided into three groups: miR-326-3p mimics group (miR-326-3p group), miR-326-3p inhibitor group (miR-326-3p-inhibit group) and scramble control group (control group)...
September 17, 2017: Nephrology
https://www.readbyqxmd.com/read/28921056/oxidative-stress-in-atherosclerosis
#6
REVIEW
Ajoe John Kattoor, Naga Venkata K Pothineni, Deepak Palagiri, Jawahar L Mehta
PURPOSE OF REVIEW: Atherosclerosis is now considered a chronic inflammatory disease. Oxidative stress induced by generation of excess reactive oxygen species has emerged as a critical, final common mechanism in atherosclerosis. Reactive oxygen species (ROS) are a group of small reactive molecules that play critical roles in the regulation of various cell functions and biological processes. Although essential for vascular homeostasis, uncontrolled production of ROS is implicated in vascular injury...
September 18, 2017: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/28919876/peptide-composition-of-stroke-causing-emboli-correlate-with-serum-markers-of-atherosclerosis-and-inflammation
#7
Neal M Rao, Joseph Capri, Whitaker Cohn, Maram Abdaljaleel, Lucas Restrepo, Jeffrey A Gornbein, William H Yong, David S Liebeskind, Julian P Whitelegge
INTRODUCTION: The specific protein composition of stroke-causing emboli is unknown. Because ischemic stroke has a varied etiology, it is possible that the composition of the thrombus from which an embolus originated will have distinctive molecular characteristics reflective of the underlying pathophysiology. We used mass spectrometry to evaluate the protein composition of retrieved emboli from patients with differing stroke etiologies and correlated the protein levels to serum predictors of atherosclerosis...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28919772/anti-pcsk9-antibodies-for-the-treatment-of-heterozygous-familial-hypercholesterolemia-patient-selection-and-perspectives
#8
REVIEW
Alberico Luigi Catapano, Angela Pirillo, Giuseppe Danilo Norata
Heterozygous familial hypercholesterolemia (FH) is a genetic disorder characterized by high low-density lipoprotein cholesterol levels from birth, which exposes the arteries to high levels of atherogenic lipoproteins lifelong and results in a significantly increased risk of premature cardiovascular events. The diagnosis of FH, followed by an appropriate and early treatment is critical to reduce the cardiovascular burden in this population. Phase I-III clinical trials showed the benefit of proprotein convertase subtilisin kexin 9 inhibitors, both alirocumab and evolocumab, in these patients with an average low-density lipoprotein cholesterol reduction ranging from -40% to -60%...
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/28919755/synthetic-high-density-lipoprotein-nanodisks-for-targeted-withalongolide-delivery-to-adrenocortical-carcinoma
#9
Rui Kuai, Chitra Subramanian, Peter T White, Barbara N Timmermann, James J Moon, Mark S Cohen, Anna Schwendeman
Adrenocortical carcinoma (ACC) is a rare endocrine malignancy and has a 5-year survival rate of <35%. ACC cells require cholesterol for steroid hormone production, and this requirement is met via expression on the cell surface of a high level of SRB1, responsible for the uptake of high-density lipoproteins (HDLs), which carry and transport cholesterol in vivo. Here, we describe how this natural lipid carrier function of SRB1 can be utilized to improve the tumor-targeted delivery of a novel natural product derivative - withalongolide A 4,19,27-triacetate (WGA-TA) - which has shown potent antitumor efficacy, but poor aqueous solubility...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28919240/single-nucleotide-variants-associated-with-polygenic-hypercholesterolemia-in-families-diagnosed-clinically-with-familial-hypercholesterolemia
#10
Itziar Lamiquiz-Moneo, María Rosario Pérez-Ruiz, Estíbaliz Jarauta, María Teresa Tejedor, Ana M Bea, Rocío Mateo-Gallego, Sofía Pérez-Calahorra, Lucía Baila-Rueda, Victoria Marco-Benedí, Isabel de Castro-Orós, Ana Cenarro, Fernando Civeira
INTRODUCTION AND OBJECTIVES: Approximately 20% to 40% of clinically defined familial hypercholesterolemia cases do not show a causative mutation in candidate genes, and some of them may have a polygenic origin. A cholesterol gene risk score for the diagnosis of polygenic hypercholesterolemia has been demonstrated to be valuable to differentiate polygenic and monogenic hypercholesterolemia. The aim of this study was to determine the contribution to low-density lipoprotein cholesterol (LDL-C) of the single nucleotide variants associated with polygenic hypercholesterolemia in probands with genetic hypercholesterolemia without mutations in candidate genes (nonfamilial hypercholesterolemia genetic hypercholesterolemia) and the genetic score in cascade screening in their family members...
September 14, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/28918546/systemic-effects-of-repeated-intraocular-dexamethasone-intravitreal-implant-in-diabetic-patients-a-retrospective-study
#11
Alicia Valverde-Megías, Pilar Cifuentes-Canorea, Jorge Ruiz-Medrano, Pablo Peña-García, Alicia Megías-Fresno, Juan Donate-López, Julián García-Feijoo
INTRODUCTION: The objective of this study is to evaluate the influence of repeated intraocular dexamethasone implant (Ozurdex) injections on metabolic control in type 2 diabetic patients. METHODS: Retrospective study of 165 type 2 diabetic patients starting Ozurdex treatment who received no less than three consecutive injections. Glycated hemoglobin (HbA1c), serum creatinine, total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, and triglycerides (TGs) were evaluated during 15 months of follow-up after Ozurdex treatment onset...
September 16, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/28918492/decreased-plasma-neuregulin-4-concentration-is-associated-with-increased-high-sensitivity-c-reactive-protein-in-newly-diagnosed-type-2-diabetes-mellitus-patients-a-cross-sectional-study
#12
Pi-Jun Yan, Yong Xu, Qin Wan, Jian Feng, Hua Li, Chen-Lin Gao, Jun Yang, Hai-Hua Zhong, Zhi-Hong Zhang
AIMS: Inflammation has been reported to be involved in the pathogenesis of atherosclerosis. This principal objective of this study was to investigate if the secretion of neuregulin 4 (Nrg4), a soluble protein associated with metabolic syndrome and subclinical cardiovascular disease, is correlated with the inflammation marker high-sensitivity C-reactive protein (hs-CRP) in patients with newly diagnosed type 2 diabetes mellitus (nT2DM). METHODS: A study group of 311 nT2DM patients was divided into three subgroups based on hs-CRP tertiles...
September 16, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28918476/effects-of-stocking-density-on-lipid-deposition-and-expression-of-lipid-related-genes-in-amur-sturgeon-acipenser-schrenckii
#13
Yuanyuan Ren, Haishen Wen, Yun Li, Jifang Li, Feng He, Meng Ni
To investigate the correlation between lipid deposition variation and stocking density in Amur sturgeon (Acipenser schrenckii) and the possible physiological mechanism, fish were conducted in different stocking densities (LSD 5.5 kg/m(3), MSD 8.0 kg/m(3), and HSD 11.0 kg/m(3)) for 70 days and then the growth index, lipid content, lipase activities, and the mRNA expressions of lipid-related genes were examined. Results showed that fish subjected to higher stocking density presented lower final body weights (FBW), specific growth ratio (SGR), and gonad adipose tissue index (GAI) (P < 0...
September 16, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/28917713/the-bvas-is-an-independent-predictor-of-cardiovascular-events-and-cardiovascular-disease-related-mortality-in-patients-with-anca-associated-vasculitis-a-study-of-504-cases-in-a-single-chinese-center
#14
Yi-Hua Bai, Zhi-Ying Li, Dong-Yuan Chang, Min Chen, Cees G M Kallenberg, Ming-Hui Zhao
BACKGROUND: Cardiovascular diseases (CVD) are the major causes of death in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) during long-term follow-up. This study investigated risk factors for cardiovascular events (CVE) and CVD-related mortality in Chinese AAV patients. METHODS: Five hundred and four AAV patients in our center were retrospectively included. The predictive value of variables associated with CVE and CVD-related mortality were analyzed...
August 31, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28917588/association-between-fsp-cvhi-inflammatory-cytokines-and-the-incidence-of-primary-stroke
#15
Xiao-Yun Huang, Wen-Jin Fu, Zhi-Chang Chen, Zhi-Zhong Mei, Ying-Li Yu, Hao-Wei Fang, Yi-Hong Huang, Han Lin, Jian-Jun Chen, Ming-Xia Wang, Shao-Bing Guan, Wan-Xian Lu, Xiao-Ling Chen
This case-control study was designed to establish a new risk-prediction model for primary stroke using Framingham stroke profile (FSP), cerebral vascular hemodynamic indexes (CVHI) and plasma inflammatory cytokines including hs-CRP, IL-6, TNF-α and Lp-PLA2. A total of 101 primary stroke patients admitted to Dongguan Houjie Hospital between August 2014 and June 2015 were assigned into the case group, and 156 age- and gender-matched healthy subjects from the Houjie Community were allocated into the control group...
September 13, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28917309/toxic-action-of-acmella-oleracea-extract-on-the-male-reproductive-system-of-amblyomma-cajennense-ticks
#16
Luís Adriano Anholeto, Patrícia Rosa de Oliveira, Rodney Alexandre Ferreira Rodrigues, Lais Thiemi Yamane, Karina Neoob de Carvalho Castro, Allan Roberto Fernandes Ferreira, Maria Izabel Camargo-Mathias
The present study evaluated through morphohistological and histochemical techniques the effects of different concentrations of crude ethanolic extract of A. oleracea (EEAO) (Jambu) on the male reproductive system of Amblyomma cajennense sensu stricto (s.s.) ticks. The toxicity of this natural chemical was stablished, signalizing the promising potential of the compound as a strategy to control ectoparasites in the near future. For the experiment, 100 males fed on host rabbits with homogeneous weight (p>0...
September 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28917230/energy-restriction-combined-with-green-coffee-bean-extract-affects-serum-adipocytokines-and-the-body-composition-in-obese-women
#17
Fatemeh Haidari, Mehnoosh Samadi, Majid Mohammadshahi, Mohammad Taha Jalali, Kambiz Ahmadi Engali
BACKGROUND AND OBJECTIVES: Obesity has become a public health problem and is a cause of some preventable illnesses. Among several methods for treating obesity, the use of food supplements is highly common. A commonly used food supplement is green coffee bean extract. The objective of this study was to evaluate the efficacy of green coffee bean extract combined with an energy-restricted diet on the body composition and serum adipocytokines in obese women. METHODS AND STUDY DESIGN: In this randomised clinical trial, 64 obese women aged 20-45 years were selected and divided into two groups: an intervention group (receiving 400 mg green coffee bean extract for 8 weeks) and control group (receiving placebo)...
2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28916975/flaxseed-oil-supplementation-improve-gene-expression-levels-of-ppar-%C3%AE-lp-a-il-1-and-tnf-%C3%AE-in-type-2-diabetic-patients-with-coronary-heart-disease
#18
Ali Akbar Hashemzadeh, Nikoo Nasoohi, Fariba Raygan, Esmat Aghadavod, Elmira Akbari, Mohsen Taghizadeh, Mohammad Reza Memarzadeh, Zatollah Asemi
This study was carried out to determine the effects of flaxseed oil administration on gene expression levels related to insulin, lipid and inflammation in overweight diabetic patients with coronary heart disease (CHD). This randomized double-blind, placebo-controlled trial was conducted among 60 diabetic patients with CHD. Subjects were randomly allocated into two groups to intake either 1000 mg n-3 fatty acid from flaxseed oil containing 400 mg α-Linolenic acid [ALA (18:3n-3)] (n = 30) or placebo (n = 30) twice a day for 12 weeks...
September 15, 2017: Lipids
https://www.readbyqxmd.com/read/28916714/interleukin-6-blockade-raises-ldl-via-reduced-catabolism-rather-than-via-increased-synthesis-a-cytokine-specific-mechanism-for-cholesterol-changes-in-rheumatoid-arthritis
#19
Jamie Robertson, Duncan Porter, Naveed Sattar, Chris J Packard, Muriel Caslake, Iain McInnes, David McCarey
OBJECTIVES: Patients with rheumatoid arthritis (RA) have reduced serum low-density lipoprotein cholesterol (LDL-c), which increases following therapeutic IL-6 blockade. We aimed to define the metabolic pathways underlying these lipid changes. METHODS: In the KALIBRA study, lipoprotein kinetic studies were performed on 11 patients with severe active RA at baseline and following three intravenous infusions of the IL-6R blocker tocilizumab. The primary outcome measure was the fractional catabolic rate (FCR) of LDL...
September 15, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28916633/systems-genetics-identifies-a-co-regulated-module-of-liver-micrornas-associated-with-plasma-ldl-cholesterol-in-murine-diet-induced-dyslipidemia
#20
Alisha R Coffey, Tangi L Smallwood, Jody Albright, Kunjie Hua, Matt Kanke, Daniel Pomp, Brian J Bennett, Praveen Sethupathy
Chronically altered levels of circulating lipids, termed dyslipidemia, is a significant risk factor for a number of metabolic and cardiovascular morbidities. MicroRNAs (miRNAs) have emerged as important regulators of lipid balance, have been implicated in dyslipidemia, and have been proposed as candidate therapeutic targets in lipid-related disorders including atherosclerosis. A major limitation of most murine studies of miRNAs in lipid metabolic disorders is that they have been performed in just one (or very few) inbred strains, such as C57BL/6...
September 15, 2017: Physiological Genomics
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