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https://www.readbyqxmd.com/read/27915212/rapid-detection-and-evolutionary-analysis-of-legionella-pneumophila-serogroup-1-sequence-type-47
#1
M Mentasti, P Cassier, S David, C Ginevra, L Gomez-Valero, A Underwood, B Afshar, J Etienne, J Parkhill, V Chalker, C Buchrieser, T G Harrison, S Jarraud
OBJECTIVES: Legionella pneumophia serogroup 1 (Lp1) sequence type 47 is the leading cause of legionellosis in North-Western Europe but surprisingly it is rarely isolated from environmental samples. Comparative genomics was applied to develop a PCR assay and to better understand the evolution of this strain. METHODS: Comparative analysis of 36 genomes representative of the Lp species was used to identify specific PCR targets which were then evaluated in silico on 545 sequenced genomes, and in vitro on 436 Legionella strains, 106 respiratory samples and three environmental samples from proven ST47 sources...
November 30, 2016: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/27915117/from-intentions-to-actions-neural-oscillations-encode-motor-processes-through-phase-amplitude-and-phase-amplitude-coupling
#2
Etienne Combrisson, Marcela Perrone-Bertolotti, Juan Lp Soto, Golnoush Alamian, Philippe Kahane, Jean-Philippe Lachaux, Aymeric Guillot, Karim Jerbi
Goal-directed motor behavior is associated with changes in patterns of rhythmic neuronal activity across widely distributed brain areas. In particular, movement initiation and execution are mediated by patterns of synchronization and desynchronization that occur concurrently across distinct frequency bands and across multiple motor cortical areas. To date, motor-related local oscillatory modulations have been predominantly examined by quantifying increases or suppressions in spectral power. However, beyond signal power, spectral properties such as phase and phase-amplitude coupling (PAC) have also been shown to carry information with regards to the oscillatory dynamics underlying motor processes...
November 30, 2016: NeuroImage
https://www.readbyqxmd.com/read/27914033/l-carnitine-simvastatin-reduces-lipoprotein-a-levels-compared-with-simvastatin-monotherapy-a-randomized-double-blind-placebo-controlled-study
#3
M Florentin, M S Elisaf, C V Rizos, V Nikolaou, E Bilianou, C Pitsavos, E N Liberopoulos
Lipoprotein (a) [Lp(a)] is an independent risk factor for cardiovascular disease. There are currently limited therapeutic options to lower Lp(a) levels. L-Carnitine has been reported to reduce Lp(a) levels. The aim of this study was to compare the effect of L-carnitine/simvastatin co-administration with that of simvastatin monotherapy on Lp(a) levels in subjects with mixed hyperlipidemia and elevated Lp(a) concentration. Subjects with levels of low-density lipoprotein cholesterol (LDL-C) >160 mg/dL, triacylglycerol (TAG) >150 mg/dL and Lp(a) >20 mg/dL were included in this study...
December 2, 2016: Lipids
https://www.readbyqxmd.com/read/27913307/urothelium-adherent-ion-triggered-liposome-in-gel-system-as-a-platform-for-intravesical-drug-delivery
#4
Shruti GuhaSarkar, Prachi More, Rinti Banerjee
Instillations of therapeutic agents into the urinary bladder have limited efficacy due to drug washout and inadequate attachment to and penetration into the bladder wall. Instilled nanoparticles alone have low stability and high susceptibility to washout, while gel-based systems are difficult to administer and retain. To overcome disadvantages of current technologies, a biodegradable, in situ-gelling liposome-in-gel (LP-Gel) system was developed for instillation into the bladder, composed of nano-sized, fluidizing liposomes incorporated into a "smart" biopolymeric, urine-triggered hydrogel...
November 29, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27910384/dual-langmuir-probe-array-for-3d-plasma-studies-in-torpex
#5
M Baquero-Ruiz, F Avino, O Chellai, A Fasoli, I Furno, R Jacquier, F Manke, S Patrick
We have designed and installed a new Langmuir-probe (LP) array diagnostic to determine basic three-dimensional (3D) features of plasmas in TORPEX. The diagnostic consists of two identical LP arrays, placed on opposite sides of the apparatus, which provide comprehensive coverage of the poloidal cross section at the two different toroidal locations. Cross correlation studies of signals from the arrays provide a basic way to extract 3D information from the plasmas, as experiments show. Moreover, the remarkable signal-to-noise performance of the front-end electronics allows us to follow a different approach in which we combine information from all probes in both arrays to reconstruct elementary 3D plasma structures at each acquisition time step...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27908719/ultrahigh-pressure-assisted-enzymatic-extraction-maximizes-the-yield-of-longan-pulp-polysaccharides-and-their-acetylcholinesterase-inhibitory-activity-in-vitro
#6
Yajuan Bai, Lei Liu, Ruifen Zhang, Fei Huang, Yuanyuan Deng, Mingwei Zhang
An extraction method employing ultrahigh pressure-assisted enzymatic treatment was developed and optimized by response surface methodology to increase the yield of longan pulp polysaccharides (LP-UE). A maximum polysaccharides yield of 8.55% was obtained under the optimal conditions of 407MPa ultrahigh pressure maintained for 6min with an enzyme to pretreated material ratio of 1:100, an enzymolysis time of 1.7h and a water to pretreated material ratio of 42ml/g. Subsequently, the physicochemical properties and acetylcholinesterase (AChE) inhibitory activity of LP-UE were compared to those of longan pulp polysaccharides (LP) extracted by hot water (LP-H), ultrahigh pressure (LP-U) or enzymatic treatment (LP-E)...
November 28, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27908200/development-of-an-internet-version-of-the-lidcombe-program-of-early-stuttering-intervention-a-trial-of-part-1
#7
Sabine Van Eerdenbrugh, Ann Packman, Mark Onslow, Sue O'brian, Ross Menzies
PURPOSE: There is evidence that access to treatment for early stuttering is not available for all who need it. An internet version of the Lidcombe Program for early stuttering (Internet-LP) has been developed to deal with this shortfall. The LP is suitable for such development because it is delivered by parents in the child's everyday environment, with training by a speech-language pathologist. A Phase I trial of Internet-LP Part 1, comprising parent training, is reported here. METHOD: Eight parents of pre-schoolers who stutter were recruited and six completed the trial...
December 2, 2016: International Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/27908179/an-evaluation-of-spatial-resolution-of-a-prototype-proton-ct-scanner
#8
Tia E Plautz, V Bashkirov, V Giacometti, R F Hurley, R P Johnson, P Piersimoni, H F-W Sadrozinski, R W Schulte, A Zatserklyaniy
PURPOSE: To evaluate the spatial resolution of proton CT using both a prototype proton CT scanner and Monte Carlo simulations. METHODS: A custom cylindrical edge phantom containing twelve tissue-equivalent inserts with four different compositions at varying radial displacements from the axis of rotation was developed for measuring the modulation transfer function (MTF) of a prototype proton CT scanner. Two scans of the phantom, centered on the axis of rotation, were obtained with a 200 MeV, low-intensity proton beam: one scan with steps of 4°, and one scan with the phantom continuously rotating...
December 2016: Medical Physics
https://www.readbyqxmd.com/read/27906350/high-power-transverse-mode-switchable-all-fiber-picosecond-mopa
#9
Tong Liu, Shengping Chen, Xue Qi, Jing Hou
A high-power transverse-mode-switchable all-fiber picosecond laser in a master-oscillator power-amplifier (MOPA) configuration is demonstrated. The master oscillator is a gain-switched laser diode delivering picosecond pulses with 25 MHz repetition rate at the wavelength of 1.06 μm. After multi-stage amplification in ytterbium-doped fibers, the average output power is scaled to 117 W. A mechanical long-period grating is employed as a fiber mode convertor to achieve controllable conversion from the fundamental (LP<sub>01</sub>) to the second-order (LP<sub>11</sub>) mode...
November 28, 2016: Optics Express
https://www.readbyqxmd.com/read/27906336/in-line-optofluidic-refractive-index-sensing-in-a-side-channel-photonic-crystal-fiber
#10
Nan Zhang, Georges Humbert, Zhifang Wu, Kaiwei Li, Perry Ping Shum, Nancy Meng Ying Zhang, Ying Cui, Jean-Louis Auguste, Xuan Quyen Dinh, Lei Wei
An in-line optofluidic refractive index (RI) sensing platform is constructed by splicing a side-channel photonic crystal fiber (SC-PCF) with side-polished single mode fibers. A long-period grating (LPG) combined with an intermodal interference between LP<sub>01</sub> and LP<sub>11</sub> core modes is used for sensing the RI of the liquid in the side channel. The resonant dip shows a nonlinear wavelength shift with increasing RI over the measured range from 1.3330 to 1.3961. The RI response of this sensing platform for a low RI range of 1...
November 28, 2016: Optics Express
https://www.readbyqxmd.com/read/27906204/design-of-a-large-field-of-view-see-through-near-to-eye-display-with-two-geometrical-waveguides
#11
Jianming Yang, Patrice Twardowski, Philippe Gérard, Joël Fontaine
A novel waveguide near to eye display (WGNED), with new in-coupling and propagation subsystems, is proposed for the first time, to our knowledge, to enlarge the vertical field-of-view (FOV) and the vertical size of the eye box. Two waveguides are stacked-one is for in-coupling and the other for out-coupling. A freeform prism is used to correct the aberrations. These components are combined to form the WGNED. We have simulated such a system; as a result, we show that it achieves a FOV of 30°horizontal (H)×60°vertical (V) and an eye box of about 15  mm (H)×12  mm (V)...
December 1, 2016: Optics Letters
https://www.readbyqxmd.com/read/27905470/a-previously-unreported-impact-of-a-pla2g7-gene-polymorphism-on-the-plasma-levels-of-lipoprotein-associated-phospholipase-a2-activity-and-mass
#12
Yue Qi, Dong Zhao, Zhangrong Jia, Wei Wang, Miao Wang, Jiayi Sun, Jun Liu, Yan Li, Wuxiang Xie, Jing Liu
Lipoprotein-associated phospholipase A2 (Lp-PLA2) levels are associated with the development of atherosclerosis. We aimed to assess the genetic determinants of Lp-PLA2 activity and mass by genotyping multiple polymorphisms in PLA2G7, the gene encoding Lp-PLA2, among 1258 participants from the Chinese Multi-provincial Cohort Study-Beijing Project. The Sequenom MassARRAY system, Taqman assay and direct sequencing were adopted. For the first time, the rs13218408 polymorphism was found to be significantly associated with reduced Lp-PLA2 levels...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27905032/characteristics-of-lipoprotein-a-containing-circulating-immune-complexes-as-markers-of-coronary-heart-disease
#13
E A Klesareva, O I Afanas'eva, V V Donskikh, I Yu Adamova, S N Pokrovskii
We studied the composition of circulating immune complexes precipitated in the presence of various concentrations of polyethylene glycol in patients with coronary heart disease (CHD) and high concentration of lipoprotein(a) - Lp(a). Precipitation of highly purified Lp(a) preparation with polyethylene glycol was evaluated. The contents of Lp(a), autoantibodies to Lp(a), IgG, and IgM in circulating immune complexes isolated from the sera of donors and CHD patients with normal and high levels of Lp(a) were measured...
December 1, 2016: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27903724/a-comparison-of-visual-response-properties-in-the-lateral-geniculate-nucleus-and-primary-visual-cortex-of-awake-and-anesthetized-mice
#14
Séverine Durand, Ramakrishnan Iyer, Kenji Mizuseki, Saskia de Vries, Stefan Mihalas, R Clay Reid
: The cerebral cortex of the mouse has become one of the most important systems for studying information processing and the neural correlates of behavior. Multiple studies have examined the first stages of visual cortical processing: primary visual cortex (V1) and its thalamic inputs from the dorsal lateral geniculate nucleus (dLGN), but more rarely in the lateral posterior nucleus (LP) in mice. Multiple single-unit surveys of dLGN and V1, both with electrophysiology and two-photon calcium imaging, have described receptive fields in anesthetized animals...
November 30, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27903455/complexation-hydrogels-as-potential-carriers-in-oral-vaccine-delivery-systems
#15
Mia Yoshida, Noriyasu Kamei, Keiya Muto, Jun Kunisawa, Kozo Takayama, Nicholas A Peppas, Mariko Takeda-Morishita
Most current vaccine preparations are in injectable forms, which are inconvenient to patients and ineffective in mucosal immunization. Therefore, most research in this field has been directed at developing ideal oral vaccines enabling the induction of both systemic and mucosal immune responses. In the present study, we examined the utility of a pH-responsive polymeric carrier, poly (methacrylic acid-g-ethylene glycol) [P (MAA-g-EG)] hydrogel, as a potential oral vaccine carrier that can protect cargo proteins in the gastrointestinal tract...
November 26, 2016: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/27902945/artificial-cervical-disc-replacement-with-the-prestige-lp-prosthesis-for-the-treatment-of-non-contiguous-2-level-cervical-degenerative-disc-disease-a-minimum-24-month-follow-up
#16
Tingkui Wu, Beiyu Wang, Chen Ding, Yang Meng, Jigang Lou, Yi Yang, Hao Liu
OBJECTIVE: We describe the features of non-contiguous 2-level cervical degenerative disc disease (NCDDD), investigate the safety and feasibility of artificial cervical disc replacement (ACDR) for the treatment of NCDDD, and expect that our study will provide spine surgeons with an alternative procedure for NCDDD. METHODS: Twenty-five patients with NCDDD received ACDR with a Prestige-LP prosthesis. Clinical outcomes were evaluated using the 36-Short Form (SF-36, Mental Component Summary [MCS] and Physical Component Summary [PCS]), Visual Analog Scale (VAS), Japanese Orthopedic Association (JOA), and Neck Disability Index (NDI) scores...
November 17, 2016: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/27902603/purulent-lupus-panniculitis-unmasked-by-fdg-pet-ct-scan-a-case-report
#17
Kornelis S M van der Geest, Rada V Moerman, Klaas P Koopmans, Nicole D Holman, Wilbert M T Janssen
RATIONALE: Lupus panniculitis (LP) is a unique variant of cutaneous lupus erythematosus. Clinical manifestations are typically mild and include erythema, nodules, and small ulcers. In certain cases, diagnosing LP may be challenging. Skin overlying the typical subcutaneous inflammation may appear normal, and bacterial superinfections of the skin sometimes mask the underlying LP. It has been suggested that a computed tomography (CT) scan may help to identify obscure LP lesions. Here, we report a case of a 54-year-old woman with an unusually severe form of LP, in which the full disease extent was only revealed by a fluorodeoxyglucose positron emission tomography (FDG-PET)/CT scan...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27900487/lipoid-proteinosis-unveiled-by-oral-mucosal-lesions-a-comprehensive-analysis-of-137-cases
#18
Boaz Frenkel, Marilena Vered, Shlomo Taicher, Noam Yarom
OBJECTIVES: Lipoid proteinosis (LP) is a rare autosomal recessive disorder characterized by deposits of hyaline material within skin and mucous membranes of the upper aerodigestive tract, especially the vocal cords. We aimed to investigate possible associations between oral LP (oLP) manifestations and demographic data and extra-oral lesions. MATERIAL AND METHODS: Cases of oLP were collected following a systematic search of Medline's PubMed and Google Scholar (1948-2014)...
November 29, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27900483/indigo-naturalis-ameliorates-murine-dextran-sodium-sulfate-induced-colitis-via-aryl-hydrocarbon-receptor-activation
#19
Shoichiro Kawai, Hideki Iijima, Shinichiro Shinzaki, Satoshi Hiyama, Toshio Yamaguchi, Manabu Araki, Shuko Iwatani, Eri Shiraishi, Akira Mukai, Takahiro Inoue, Yoshito Hayashi, Masahiko Tsujii, Daisuke Motooka, Shota Nakamura, Tetsuya Iida, Tetsuo Takehara
BACKGROUND: Indigo Naturalis (IN) is used as a traditional herbal medicine for ulcerative colitis (UC). However, the mechanisms of action of IN have not been clarified. We aimed to evaluate the efficacy of IN for ameliorating colonic inflammation. We further investigated the mechanisms of action of IN. METHODS: Colitis severity was assessed in dextran sodium sulfate-induced colitis and trinitrobenzene sulfonic acid-induced colitis models with or without the oral administration of IN or indigo, which is a known major component of IN...
November 29, 2016: Journal of Gastroenterology
https://www.readbyqxmd.com/read/27900155/normal-platelet-function-in-platelet-concentrates-requires-non-platelet-cells-a-comparative-in-vitro-evaluation-of-leucocyte-rich-type-1a-and-leucocyte-poor-type-3b-platelet-concentrates
#20
William R Parrish, Breana Roides, Julia Hwang, Michael Mafilios, Brooks Story, Samir Bhattacharyya
BACKGROUND: Therapeutic success of platelet-rich plasma (PRP) may vary based on the composition and preparation method. The objective of this study was to evaluate the cellular components of platelet concentrates produced by a leucocyte-rich (LR-PRP) and a leucocyte-poor PRP systems (LP-PRP). METHODS: Parameters evaluated included platelet recovery, platelet concentration, red blood cell (RBC) and white blood cell (WBC) composition, platelet growth factor release and stimulation of human tendon cell proliferation in vitro...
2016: BMJ Open Sport & Exercise Medicine
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