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https://www.readbyqxmd.com/read/29139206/periodically-arranged-arrays-of-dendritic-pt-nanospheres-using-cage-type-mesoporous-silica-as-a-hard-template
#1
Kenya Kani, Victor Malgras, Bo Jiang, Md Shahriar A Hossain, Saad M Alshehri, Tansir Ahamad, Rahul R Salunkhe, Zhenguo Huang, Yusuke Yamauchi
Dendritic Pt nanospheres of 20 nm diameter are synthesized by using highly concentrated surfactant assembly within the large-sized cage-type mesopores of mesoporous silica (LP-FDU-12). After diluting the surfactant solution with ethanol, the lower viscosity lead to an improved penetration inside the mesopores. After Pt deposition followed by template removal, the arrangement of the Pt nanospheres is a replication from that of the mesopores in the original LP-FDU-12 template. Although it is well known that ordered LLCs can form on flat substrates, confined space inside the mesopores hinders surfactant self-organization...
November 14, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29138849/elevated-serum-levels-of-lipoprotein%C3%A2-associated-phospholipase%C3%A2-a2-predict-mortality-rates-in-patients-with-sepsis
#2
Zhongwei Huang, Haiyan Jiang, Xiaohui Cui, Guiwen Liang, Yu Chen, Ting Wang, Zhichao Sun, Lei Qi
Sepsis remains one of the leading contributors to mortality rates in the intensive care unit (ICU) and emergency intensive care unit (EICU). Therefore, any treatments against the agents which produce sepsis in a medical emergency, are welcome. Elevated serum levels of lipoprotein‑associated phospholipase A2 (Lp‑PLA2) have been reported in a small cohort of patients with inflammation. The present study evaluated serum levels of Lp‑PLA2 in patients with sepsis and investigated the role of Lp‑PLA2 in sepsis...
November 13, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29137420/anti-angiogenic-and-anti-tumor-effects-of-metronomic-use-of-novel-liposomal-zoledronic-acid-depletes-tumor-associated-macrophages-in-triple-negative-breast-cancer
#3
Xin-Jun Cai, Zeng Wang, Jia-Wei Cao, Jian-Jun Ni, Ying-Ying Xu, Jun Yao, Hong Xu, Fang Liu, Gao-Yi Yang
Zoledronic acid (ZOL) has been used as an adjuvant therapy for breast cancer. It is suggested that ZOL might be associated with inhibition of macrophages, which in turn reduces tumor growth, metastasis and tumor angiogenesis. Moreover, metronomic therapy can inhibit tumor angiogenesis and tumor immune cells. Previously we developed ZOL based cationic liposomes that allowed a higher intratumor delivery of drug compared with free ZOL in vivo. Therefore, in this study, Asn-Gly-Arg (NGR) and PEG2000 were used as ligands to modify the surface of liposomes (NGR-PEG-LP-ZOL) in metronomic therapy to clear the tumor-associated macrophages (TAMs) and inhibit the formation of tumor angiogenesis, achieving the purpose of anti-tumor growth...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29137204/optically-controllable-linear-polarization-rotator-using-chiral-azobenzene-doped-liquid-crystals
#4
Cheng-Kai Liu, Chian-Yu Chiu, Stephen M Morris, Min-Cheng Tsai, Chii-Chang Chen, Ko-Ting Cheng
A linear-polarization rotator based on the optically tunable pitch of chiral-azobenzene-doped liquid crystals (CAdLCs) has been investigated. It is shown that the orientation of linearly polarized (LP) light can be optically tuned using CAdLCs and that the transmitted light possesses a good degree of linear polarization (DoLP). Experimental and simulation (4 × 4 Berreman matrix) results show that the rotation angle is dependent on the pitch as well as the number of turns of the cholesteric LC helix. Some causes to affect the DoLP of the output LP lights during photoisomerization are also discussed...
November 13, 2017: Materials
https://www.readbyqxmd.com/read/29137183/lactobacillus-plantarum-enhanced-il-22-production-in-natural-killer-nk-cells-that-protect-the-integrity-of-intestinal-epithelial-cell-barrier-damaged-by-enterotoxigenic-escherichia-coli
#5
Yueqin Qiu, Zongyong Jiang, Shenglan Hu, Li Wang, Xianyong Ma, Xuefen Yang
Interleukin (IL)-22-producing Natural Killer (NK) cells protect the gut epithelial cell barrier from pathogens. A strain of probiotics, Lactobacillus plantarum (L. plantarum, LP), was previously found by our laboratory to significantly improve the mucosal barrier integrity and function of the small intestine in pigs. However, it was unclear whether LP benefited the intestinal mucosal barrier via interactions with the intestinal NK cells. The present study, therefore, was focused on the therapeutic effect of NK cells that were stimulated by LP on attenuating enterotoxigenic Escherichia coli (ETEC)-induced the damage to the integrity of the epithelial cell barrier...
November 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29137073/incidence-of-c5-nerve-root-palsy-after-cervical-surgery-a-meta-analysis-for-last-decade
#6
Tao Wang, Hui Wang, Sen Liu, Wen-Yuan Ding
PURPOSE: We aim to perform a meta-analysis on incidence of C5 nerve root palsy (C5 palsy) for patients after cervical surgery. METHODS: An extensive search of the literature was performed in PubMed/MEDLINE, Embase, the Cochrane library, CNKI, and WANFANG databases on incidence of C5 palsy from January 2007 to January 2017. Prevalence of C5 palsy related to different surgery methods was calculated and data analysis was conducted with STATA 12.0. RESULTS: A total of 61 studies containing 721 patients with C5 palsy in total 11,481 patients (6...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29135482/long-term-darapladib-use-does-not-affect-coronary-plaque-composition-assessed-using-multimodality-intravascular-imaging-modalities-a-randomized-controlled-study
#7
Woong Gil Choi, Megha Prasad, Ryan Lennon, Rajiv Gulati, Abhiram Prasad, Lilach O Lerman, Amir Lerman
BACKGROUND: Lipoprotein-associated phospholipase A2 (Lp-PLA2) may play a role in plaque progression and vulnerability. We aimed to define plaque characteristics on multimodality intravascular imaging in patients with coronary endothelial dysfunction in response to long-term inhibition of Lp-PLA2 by darapladib. PATIENTS AND METHODS: This is a double-blinded, randomized study screening 70 patients, and enrolling 54 patients with suspected ischemia, without obstructive disease on angiography and with coronary endothelial dysfunction by invasive assessment...
November 10, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/29135318/the-effect-and-safety-of-anacetrapib-in-the-treatment-of-dyslipidemia-a-systematic-review-and-meta-analysis
#8
Junteng Zhou, Qi Zhang, Yushu Wang, Peijuan Gao, Decai Chen
BACKGROUND: Cardiovascular disease (CVD) is the major cause of morbidity and mortality worldwide. Anacetrapib may be a new treatment option that has a cardiovascular benefit for the management of dyslipidemia. OBJECTIVE: The aim of our current study was to perform a systematic review and meta-analysis of all randomized controlled trials (RCTs) assessing the effect and safety of anacetrapib in the treatment of dyslipidemia. METHODS: We systematically searched PubMed, Embase, and Cochrane Library database from their inception to 5 October 2017, with the terms: 'anacetrapib' and 'placebo'...
November 14, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/29135242/computational-study-on-%C3%AE-c-h-functionalization-of-%C3%AE-%C3%AE-unsaturated-ester-catalyzed-by-n-heterocyclic-carbene-mechanisms-origin-of-stereoselectivity-and-role-of-catalyst
#9
Yang Wang, Donghui Wei, Mingsheng Tang
The N-heterocyclic carbene (NHC)-catalyzed γ-C-H deprotonation/functionalization of α,β-unsaturated esters with hydrazones leading to the δ-lactams has been theoretically investigated by using the density functional theory. Three possible reaction mechanisms including Mechanism A, for which the NHC catalyst serves as a nucleophilic catalyst to attack on the carbonyl carbon atom to initiate the reaction, for Mechanism B, in which NHC triggers the reaction through the hydrogen bond, and Mechanism C is the direct deprotonation/functionalization process without the presence of NHC have been suggested and studied in detail...
November 14, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29134571/optimizing-residents-performance-of-lumbar-puncture-an-rct-comparing-the-effect-of-preparatory-interventions-on-performance-and-self-confidence
#10
Mikael Johannes Vuokko Henriksen, Troels Wienecke, Helle Thagesen, Rikke Borre Vita Jacobsen, Yousif Subhi, Ryan Brydges, Charlotte Ringsted, Lars Konge
BACKGROUND: Lumbar puncture is often associated with uncertainty and limited experience on the part of residents; therefore, preparatory interventions can be essential. There is growing interest in the potential benefit of videos over written text. However, little attention has been given to whether the design of the videos impacts on subsequent performance. OBJECTIVE: To investigate the effect of different preparatory interventions on learner performance and self-confidence regarding lumbar puncture (LP)...
November 13, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29131021/a-novel-color-fluorescence-navigation-system-for-intraoperative-transcutaneous-lymphatic-mapping-and-resection-of-sentinel-lymph-nodes-in-breast-cancer-comparison-with-the-combination-of-gamma-probe-scanning-and-visible-dye-methods
#11
Norihiro Hokimoto, Takeki Sugimoto, Tsutomu Namikawa, Taku Funakoshi, Toyokazu Oki, Maho Ogawa, Hideo Fukuhara, Keiji Inoue, Takayuki Sato, Kazuhiro Hanazaki
BACKGROUND: This study evaluated the clinical efficacy of a novel imaging system (HyperEye Medical System [HEMS]; Mizuho Corp., Tokyo, Japan) that uses the near-infrared (NIR) fluorescence of indocyanine green to analyze sentinel lymph node (SLN) biopsies for the staging of breast cancer. METHODS: This study enrolled 91 patients with histologically confirmed breast cancer that was clinically node negative with a tumor size <3 cm. We compared SLN identification rates between HEMS and conventional methods (gamma probe scanning using a colloidal radioisotope [RI] and a blue dye method) by analyzing the relationships of lymphatic to axillary lesions and SLNs...
November 10, 2017: Oncology
https://www.readbyqxmd.com/read/29129821/association-between-lipoprotein-a-and-proprotein-convertase-substilisin-kexin-type-9-in-patients-with-heterozygous-familial-hypercholesterolemia-a-case-control-study
#12
Di Sun, Sha Li, Xi Zhao, Na-Qiong Wu, Cheng-Gang Zhu, Yuan-Lin Guo, Ying Gao, Ping Qing, Chuan-Jue Cui, Geng Liu, Jing Sun, Qian Dong, Jian-Jun Li
BACKGROUND: Recent data have suggested an important role of lipoprotein (a) [Lp(a)] and proprotein convertase substilisin/kexin type 9 (PCSK9) in the development of atherosclerotic cardiovascular disease (ASCVD) in both general population and family hypercholesterolemia (FH), while the relation of Lp(a) to PCSK9 has not been examined. OBJECTIVE: The aim of the present study was to investigate the association between plasma PCSK9 and Lp(a)in patients with heterozygous FH (HeFH)...
November 9, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29129666/effect-of-soy-isoflavone-supplementation-on-plasma-lipoprotein-a-concentrations-a-meta-analysis
#13
REVIEW
Luis E Simental-Mendía, Antonio M Gotto, Stephen L Atkin, Maciej Banach, Matteo Pirro, Amirhossein Sahebkar
BACKGROUND: Soy supplementation has been shown to reduce total and low-density lipoprotein cholesterol, while increasing high-density lipoprotein cholesterol. However, contradictory effects of soy isoflavone supplementation on lipoprotein(a) [Lp(a)] have been reported suggesting the need for a meta-analysis to be undertaken. OBJECTIVE: The aim of the study was to investigate the impact of supplementation with soy isoflavones on plasma Lp(a) levels through a systematic review and meta-analysis of eligible randomized placebo-controlled trials...
October 17, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29128485/neutrophil-lymphocyte-and-platelet-counts-and-acute-kidney-injury-after-cardiovascular-surgery
#14
Chang-Hoon Koo, Dhong Eun Jung, Yoon Sang Park, Jungil Bae, Youn Joung Cho, Won Ho Kim, Jae-Hyon Bahk
OBJECTIVE: Postoperative low platelet count and perioperative high neutrophil/lymphocyte (N/L) ratio are associated with acute kidney injury (AKI) and mortality after cardiac surgery. The authors investigated whether (1) their combination neutrophil/lymphocyte × platelet (N/LP) ratio is an independent predictor of AKI and postoperative mortality and (2) whether the N/LP ratio increases predictive ability compared with the N/L ratio or platelet nadir. DESIGN: This was a retrospective and observational study...
August 24, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29128221/short-communication-genetic-association-of-variations-in-the-osteopontin-gene-spp1-with-lactation-persistency-in-dairy-cattle
#15
Nathalie Bissonnette
Improving lactation persistency (LP) in dairy cattle has a beneficial effect on animal health and fertility and herd productivity. A complex trait, LP not only reflects the cow's ability to maintain milk secretion activity after the lactation peak but is also a function of the postcalving development of the mammary gland and, later on, of tissue remodeling as lactation declines. This decline is a consequence of an imbalance between cell proliferation and cell removal. In a previous study, single nucleotide polymorphisms were identified in the osteopontin (OPN) gene, SPP1...
November 8, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29127508/active-and-passive-recovery-influence-responses-of-luteinizing-hormone-and-testosterone-to-a-fatiguing-strength-loading
#16
R S Taipale, Heikki Kyröläinen, S S Gagnon, B Nindl, J Ahtiainen, K Häkkinen
The purpose of this study was to examine the acute hormonal and muscular responses to a strenuous strength loading [bilateral leg press (LP) 10 × 10 1RM] followed by loading-specific active (AR, n = 7, LP 10 × 10 × 30% 1RM) or passive (PR, n = 11, seated) recovery. The subjects were men age: 26 ± 4 years, height: 174 ± 8 cm, body mass: 75 ± 13 kg. After control measurements, experimental measurements were conducted at pre- and post-loading as well as post-recovery and next morning...
November 10, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29124372/optimal-silicon-doping-layers-of-quantum-barriers-in-the-growth-sequence-forming-soft-confinement-potential-of-eight-period-in0-2ga0-8n-gan-quantum-wells-of-blue-leds
#17
Hsiang-Chen Wang, Meng-Chu Chen, Yen-Sheng Lin, Ming-Yen Lu, Kuang-I Lin, Yung-Chen Cheng
The features of eight-period In0.2Ga0.8N/GaN quantum wells (QWs) with silicon (Si) doping in the first two to five quantum barriers (QBs) in the growth sequence of blue light-emitting diodes (LEDs) are explored. Epilayers of QWs' structures are grown on 20 pairs of In0.02Ga0.98N/GaN superlattice acting as strain relief layers (SRLs) on patterned sapphire substrates (PSSs) by a low-pressure metal-organic chemical vapor deposition (LP-MOCVD) system. Temperature-dependent photoluminescence (PL) spectra, current versus voltage (I-V) curves, light output power versus injection current (L-I) curves, and images of high-resolution transmission electron microscopy (HRTEM) of epilayers are measured...
November 9, 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/29123515/dietary-intervention-with-%C3%AE-lactoglobulin-derived-peptides-and-a-specific-mixture-of-fructo-oligosaccharides-and-bifidobacterium-breve-m-16v-facilitates-the-prevention-of-whey-induced-allergy-in-mice-by-supporting-a-tolerance-prone-immune-environment
#18
Atanaska I Kostadinova, Alba Pablos-Tanarro, Mara A P Diks, Betty C A M van Esch, Johan Garssen, Léon M J Knippels, Linette E M Willemsen
Cow's milk allergy (CMA) prevails in infants and brings increased risk of developing other allergic diseases. Oral administration of specific β-lactoglobulin (BLG)-derived peptides (PepMix) and a specific blend of short- and long-chain fructo-oligosaccharides and Bifidobacterium breve M-16V (FF/Bb) was found to partially prevent CMA development in mice. In this study, we aimed to expand the knowledge on the preventive potential and the underlying mechanisms of this approach. Three-week-old female C3H/HeOuJ mice were orally exposed to PepMix±FF/Bb prior to a 5-week oral sensitization with whole whey and cholera toxin as an adjuvant...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29121808/the-prognostic-value-of-lipoprotein-associated-phospholipase-a2-in-the-long-term-care-of-patients-with-acute-coronary-syndrome-undergoing-percutaneous-coronary-intervention
#19
Lijiao Yang, Hong Wang, Yida Zhang, Tingting Han, Wenfeng Wang
Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an independent risk factor for cardiovascular disease. Accordingly, studies from many countries around the world have shown an association between Lp-PLA2 and cardiovascular events in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI), but this association has not been documented among the Chinese. The aim of this study was to assess the use of Lp-PLA2 as a useful marker for predicting the long-term prognosis of Chinese patients with ACS undergoing PCI...
January 1, 2017: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/29120368/lactobacillus-bulgaricus-lactobacillus-rhamnosus-and-lactobacillus-paracasei-attenuate-salmonella-enteritidis-salmonella-heidelberg-and-salmonella-typhimurium-colonization-and-virulence-gene-expression-in-vitro
#20
Muhammed Shafeekh Muyyarikkandy, Mary Anne Amalaradjou
Salmonella Enteritidis (SE), Salmonella Typhimurium (ST), and Salmonella Heidelberg (SH) have been responsible for numerous outbreaks associated with the consumption of poultry meat and eggs. Salmonella colonization in chicken is characterized by initial attachment to the cecal epithelial cells (CEC) followed by dissemination to the liver, spleen, and oviduct. Since cecal colonization is critical to Salmonella transmission along the food chain continuum, reducing this intestinal association could potentially decrease poultry meat and egg contamination...
November 9, 2017: International Journal of Molecular Sciences
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