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EDITORIAL
Giovanni Volpicelli
No abstract text is available yet for this article.
March 26, 2024: The ultrasound journal
#2
JOURNAL ARTICLE
Daniele Orso, Chiara Molinari, Giacomo Bacchetti, Victor Zanini, Valentina Montanar, Roberto Copetti, Nicola Guglielmo, Tiziana Bove
BACKGROUND: Venous-arterial CO2 difference (Pv-aCO2) is a valuable marker that can identify a subset of patients in shock with inadequate cardiac output to meet tissue metabolic requirements. Some authors have found that Pv-aCO2 levels calculated from mixed vs central venous blood demonstrate a linear relationship. The purpose of this study is to determine whether there is a linear relationship between Pv-aCO2 obtained with peripheral venous blood (Pv-aCO2p) and with mixed venous blood, and the agreement between the 2 measures...
December 1, 2023: Seminars in Cardiothoracic and Vascular Anesthesia
#3
JOURNAL ARTICLE
Pamela Piscitelli, Maria Maddalena D'Errico, Carlo Vigna, Nicola Marchese, Olga Lamacchia, Andrea Fontana, Massimiliano Copetti, Roberto Pontremoli, Antonio Mirijello, Salvatore A De Cosmo
BACKGROUND AND AIMS: The CHA2 DS2 -VASc score estimates the risk of cardioembolism in patients with atrial fibrillation (AF). It also predicts vascular events and death in different clinical settings, even in the absence of AF. The R2 CHA2 DS2 -VASc score, obtained by adding the glomerular filtration rate to CHA2 DS2 -VASc, shows a higher prediction ability for new events and all-cause mortality. The present study aims to assess whether the addition of albuminuria to R2 CHA2 DS2 -VASc score further improves its discrimination ability in predicting all-cause mortality in a sample of high cardiovascular risk population...
May 13, 2023: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
#4
JOURNAL ARTICLE
Carla Maria Irene Quarato, Elisa Dama, Michele Maggi, Beatrice Feragalli, Cristina Borelli, Anna Del Colle, Marco Taurchini, Evaristo Maiello, Salvatore De Cosmo, Donato Lacedonia, Maria Pia Foschino Barbaro, Giovanna Elisiana Carpagnano, Giulia Scioscia, Paolo Graziano, Rosalinda Termine, Elisabettamaria Frongillo, Sonia Santamaria, Mariapia Venuti, Maria Arcangela Grimaldi, Stefano Notarangelo, Annarita Saponara, Massimiliano Copetti, Tommaso Colangelo, Roberto Cuttano, Dimitrios Macrodimitris, Francesco Mazzarelli, Michela Talia, Antonio Mirijello, Luca Pazienza, Rita Perna, Anna Simeone, Doriana Vergara, Antonio Varriale, Massimo Carella, Fabrizio Bianchi, Marco Sperandeo
OBJECTIVES: We validated a screening protocol in which thoracic ultrasound (TUS) acts as a first-line complementary imaging technique in selecting patients which may deserve a second-line low-dose high resolution computed tomography (HRCT) scan among a population of asymptomatic high-risk subjects for interstitial lung abnormalities (ILA) and lung cancer. Due to heavy environmental pollution burden, the district Tamburi of Taranto has been chosen as "case study" for this purpose. METHODS: From July 2018 to October 2020, 677 patients aged between 45 and 65 year and who had been living in the Tamburi district of Taranto for at least 10 years were included in the study...
2023: Frontiers in Medicine
#5
Daniele Orso, Sara Santangelo, Nicola Guglielmo, Tiziana Bove, Francesco Cilenti, Lorenzo Cristiani, Roberto Copetti
PURPOSE: Since atrial fibrillation (AF) is one of the major arrhythmias managed in hospitals worldwide, it has a major impact on public health. The guidelines agree on the desirability of cardioverting paroxysmal AF episodes. This meta-analysis aims to answer the question of which antiarrhythmic agent is most effective in cardioverting a paroxysmal AF. MATERIALS AND METHODS: A systematic review and Bayesian network meta-analysis, searching MEDLINE, Embase, and CINAHL, were performed, including randomized controlled trials (RCTs) enrolling a population of unselected adult patients with a paroxysmal AF that compared at least two pharmacological regimes to restore the sinus rhythm or a cardioversion agent against a placebo...
July 2023: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
#6
REVIEW
Giulia Gagno, Laura Padoan, Stefano D'Errico, Elisa Baratella, Davide Radaelli, Alessandra Lucia Fluca, Alessandro Pierri, Milijana Janjusevic, Elena Aleksova Noveska, Maria Assunta Cova, Roberto Copetti, Franco Cominotto, Gianfranco Sinagra, Aneta Aleksova
Pulmonary infarction (PI) is a possible consequence of pulmonary embolism (PE). The real incidence of PI could be underestimated considering only non-fatal PE presentation. However, following postmortem examination, the prevalence of PI is considerably higher. This evidence suggests the necessity of proper diagnostic protocol for identifying PI. Unfortunately, PI diagnosis can sometimes be challenging, due to the overlapping of symptoms with other diseases. Nowadays, the diagnosis is mainly based on radiological evaluation, although the combination with emerging imaging techniques such as ultrasound and nuclear scanning might improve the diagnostic algorithm for PI...
August 21, 2022: Journal of Clinical Medicine
#7
JOURNAL ARTICLE
Roberto Chioma, Lorenzo Amabili, Elena Ciarmoli, Roberto Copetti, Pier Giorgio Villani, Miria Natile, Giovanni Vento, Enrico Storti, Maria Pierro
This study investigated the effectiveness of an original Lung UltraSound Targeted Recruitment (LUSTR) protocol to improve the success of lung recruitment maneuvers (LRMs), which are performed as a rescue approach in critically ill neonates. All the LUSTR maneuvers, performed on infants with an oxygen saturation/fraction of inspired oxygen (S/F) ratio below 200, were included in this case-control study (LUSTR-group). The LUSTR-group was matched by the initial S/F ratio and underlying respiratory disease with a control group of lung recruitments performed following the standard oxygenation-guided procedure (Ox-group)...
July 12, 2022: Children
#8
JOURNAL ARTICLE
Maria Maddalena D'Errico, Pamela Piscitelli, Antonio Mirijello, Mariateresa Santoliquido, Mauro Salvatori, Carlo Vigna, Gianluigi Vendemiale, Olga Lamacchia, Andrea Fontana, Massimiliano Copetti, Roberto Pontremoli, Salvatore A De Cosmo
BACKGROUND: The CHA2 DS2 -VASc score, widely used to estimate cardioembolic risk in patients with atrial fibrillation (AF), appears to be useful also in predicting vascular adverse events and death in different sets of patients without AF. The R2 CHA2 DS2 -VASc score, which includes renal impairment, allows a better prediction of death and thromboembolism in patients without AF. The aims of our study were to assess, in a large sample of patients at high cardiovascular (CV) risk, i) the correlation between CHA2 DS2 -VASc and R2 CHA2 DS2 -VASc with all-cause mortality, and ii) to compare the performances of CHA2 DS2 -VASc and R2 CHA2 DS2 -VASc in predicting all-cause mortality...
July 1, 2022: European Journal of Clinical Investigation
#9
JOURNAL ARTICLE
Ambra Mara Giovannetti, Kenneth Ian Pakenham, Giovambattista Presti, Maria Esmeralda Quartuccio, Paolo Confalonieri, Roberto Bergamaschi, Monica Grobberio, Massimiliano Di Filippo, Mary Micheli, Giampaolo Brichetto, Francesco Patti, Massimiliano Copetti, Paola Kruger, Alessandra Solari
INTRODUCTION: REsilience and Activities for every DaY (READY) is an Acceptance and Commitment Therapy-based group resilience-training program that has preliminary empirical support in promoting quality of life and other psychosocial outcomes in people with multiple sclerosis (PwMS). Consistent with the Medical Research Council framework for developing and evaluating complex interventions, we conducted a pilot randomized controlled trial (RCT), followed by a phase III RCT. The present paper describes the phase III RCT protocol...
2022: PloS One
#10
JOURNAL ARTICLE
Andrei Ivashynka, Maurizio A Leone, Nadia Barizzone, Aliona Cucovici, Roberto Cantello, Domizia Vecchio, Miriam Zuccalà, Alessandro Pizzino, Massimiliano Copetti, Sandra D'Alfonso, Andrea Fontana
BACKGROUND AND AIMS: The association between lifestyle factors and Multiple Sclerosis (MS) disease severity and progression has been investigated to a lesser extent compared with susceptibility to the disease. We aimed to assess the impact of lifetime coffee and tea consumption on MS severity. METHODS: Design: cross-sectional study. Two hundred and eight patients (139 females and 69 males) consecutively recruited at the Department of Neurology in Novara, Italy were asked about their lifetime consumption of coffee and tea...
February 2022: Clinical Nutrition ESPEN
#11
MULTICENTER STUDY
Carmine Cristiano Di Gioia, Nicola Artusi, Giovanni Xotta, Marco Bonsano, Ugo Giulio Sisto, Marzia Tecchiolli, Daniele Orso, Franco Cominotto, Giulia Amore, Stefano Meduri, Roberto Copetti
PURPOSE: Early diagnosis of COVID-19 has a crucial role in confining the spread among the population. Lung ultrasound (LUS) was included in the diagnostic pathway for its high sensitivity, low costs, non-invasiveness and safety. We aimed to test the sensitivity of LUS to rule out COVID-19 pneumonia (COVIDp) in a population of patients with suggestive symptoms. METHODS: Multicentre prospective observational study in three EDs in Northeastern Italy during the first COVID-19 outbreak...
March 2022: Emergency Medicine Journal: EMJ
#12
JOURNAL ARTICLE
Pamela Piscitelli, Maria M D'Errico, Antonio Mirijello, Mariateresa Santoliquido, Mauro Salvatori, Carlo Vigna, Nicola Marchese, Gianluigi Vendemiale, Massimiliano Copetti, Roberto Pontremoli, Salvatore A De Cosmo
BACKGROUND AND AIM: Three vessels disease (3VD) has been associated with worse prognosis and higher mortality. Chronic kidney disease (CKD) is an independent risk factor for premature death, mostly due to coronary artery disease (CAD). We aim to examine the prognostic impact of 3VD on all-cause mortality in a cohort of high cardiovascular risk subjects undergoing coronary angiography (CA) and to explore whether low eGFR (<60 ml/min/1.73 m2 ) modulates the risk of all-cause mortality associated to 3VD...
October 9, 2021: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
#13
MULTICENTER STUDY
Massimiliano Don, Nicola Fiotti, Ruben Bizjak, Mattia Guerra, Giangiacomo Nicolini, Egidio Barbi, Ingrid Toller, Fabio Narducci, Maria Luisa Tortorella, Danica Dragovic, Roberto Copetti, Alfredo Barillari
No abstract text is available yet for this article.
February 2022: Acta Paediatrica
#14
JOURNAL ARTICLE
Alice Raineri, Rachele Campagnari, Roberto Dal Toso, Stefano Copetti, Macarena Gomez-Lira, Marta Menegazzi
Adipogenesis is a complex process in which cell commitment and mitotic clonal expansion (MCE) are in-sequence crucial events leading to terminal adipocyte differentiation. The molecules able to block some key signals in this cascade can hamper adipogenesis becoming promising agents to counteract hyperplasia and hypertrophy of adipose tissue. Mono- and di-caffeoylquinic acid isomers are biologically active polyphenols, displaying in vitro and in vivo antioxidant, hepatoprotective, anti-diabetic and anti-obesity properties...
August 19, 2021: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
#15
JOURNAL ARTICLE
Jing Liu, Guo Guo, Dalibor Kurepa, Giovanni Volpicelli, Erich Sorantin, Jovan Lovrenski, Almudena Alonso-Ojembarrena, Kai-Sheng Hsieh, Abhay Lodha, Tsu F Yeh, Mateusz Jagła, Heli Shah, Wei Yan, Cai-Bao Hu, Xiao-Guang Zhou, Rui-Jun Guo, Hai-Ying Cao, Yan Wang, Hai-Feng Zong, Li-Li Shang, Hai-Ran Ma, Ying Liu, Wei Fu, Rui-Yan Shan, Ru-Xin Qiu, Xiao-Ling Ren, Roberto Copetti, Javier Rodriguez-Fanjul, Francesco Feletti
Lung ultrasound (LUS) is now widely used in the diagnosis and monitor of neonatal lung diseases. Nevertheless, in the published literatures, the LUS images may display a significant variation in technical execution, while scanning parameters may influence diagnostic accuracy. The inter- and intra-observer reliabilities of ultrasound exam have been extensively studied in general and in LUS. As expected, the reliability declines in the hands of novices when they perform the point-of-care ultrasound (POC US). Consequently, having appropriate guidelines regarding to technical aspects of neonatal LUS exam is very important especially because diagnosis is mainly based on interpretation of artifacts produced by the pleural line and the lungs...
March 2022: Journal of Maternal-fetal & Neonatal Medicine
#16
REVIEW
Andrea Boccatonda, Giulio Cocco, Eugenia Ianniello, Marco Montanari, Damiano D'Ardes, Claudio Borghi, Fabrizio Giostra, Roberto Copetti, Cosima Schiavone
A first screening by ultrasound can be relevant to set a specific diagnostic and therapeutic route for a patient with a COVID-19 infection. The finding of bilateral B-lines and white lung areas with patchy peripheral distribution and sparing areas is the most suggestive ultrasound picture of COVID-19 pneumonia. Failure to detect bilateral interstitial syndrome (A pattern) on ultrasound excludes COVID-19 pneumonia with good diagnostic accuracy, but does not exclude current infection. The use of shared semiotic and reporting schemes allows the comparison and monitoring of the COVID-19 pulmonary involvement over time...
April 13, 2021: Journal of Ultrasound
#17
JOURNAL ARTICLE
Mylena Spina, Wilson Venâncio, Caio Rodrigues-Silva, Rhannanda Copetti Pivetta, Vinicius Diniz, Susanne Rath, José Roberto Guimarães
Photoperoxidation (UV/H2 O2 ) was used to degrade three of the worldwide most consumed antidepressant pharmaceuticals-bupropion, escitalopram, and fluoxetine-in ultrapure water, drinking tap water, surface water, and reclaimed water. The study was performed with antidepressants in concentration levels in which these compounds usually occur in the water matrices. Online solid-phase extraction coupled to UHPLC-MS/MS was used to quantify the analytes during degradation studies. The UV/H2 O2 process was able to degrade bupropion and fluoxetine in ultrapure water, using 0...
January 8, 2021: Environmental Science and Pollution Research International
#18
JOURNAL ARTICLE
Riccardo Inchingolo, Roberto Copetti, Andrea Smargiassi, Rafael Emanuele Gerardi, Emanuele Giovanni Conte, Giuseppe Maria Corbo, Antonio Gatto, Chiara Pierandrei, Lavinia Capossela, Ilaria Lazzareschi, Piero Valentini, Libertario Demi
AIMS: Chest ultrasound is a non-invasive method for evaluating children with suspected community-acquired pneumonia (CAP). We evaluated the prognostic role of change of ultrasonographic (US) air bronchogram in management of CAP in terms of: rate of complicated CAP, change of empiric antibiotic therapy, relationship to defervescence time, and length of hospitalization. METHODS: Patients with CAP and radiographic evidence of lung consolidation were prospectively enrolled...
June 2021: Journal of Ultrasound
#19
REVIEW
Arif Hussain, Gabriele Via, Lawrence Melniker, Alberto Goffi, Guido Tavazzi, Luca Neri, Tomas Villen, Richard Hoppmann, Francesco Mojoli, Vicki Noble, Laurent Zieleskiewicz, Pablo Blanco, Irene W Y Ma, Mahathar Abd Wahab, Abdulmohsen Alsaawi, Majid Al Salamah, Martin Balik, Diego Barca, Karim Bendjelid, Belaid Bouhemad, Pablo Bravo-Figueroa, Raoul Breitkreutz, Juan Calderon, Jim Connolly, Roberto Copetti, Francesco Corradi, Anthony J Dean, André Denault, Deepak Govil, Carmela Graci, Young-Rock Ha, Laura Hurtado, Toru Kameda, Michael Lanspa, Christian B Laursen, Francis Lee, Rachel Liu, Massimiliano Meineri, Miguel Montorfano, Peiman Nazerian, Bret P Nelson, Aleksandar N Neskovic, Ramon Nogue, Adi Osman, José Pazeli, Elmo Pereira-Junior, Tomislav Petrovic, Emanuele Pivetta, Jan Poelaert, Susanna Price, Gregor Prosen, Shalim Rodriguez, Philippe Rola, Colin Royse, Yale Tung Chen, Mike Wells, Adrian Wong, Wang Xiaoting, Wang Zhen, Yaseen Arabi
COVID-19 has caused great devastation in the past year. Multi-organ point-of-care ultrasound (PoCUS) including lung ultrasound (LUS) and focused cardiac ultrasound (FoCUS) as a clinical adjunct has played a significant role in triaging, diagnosis and medical management of COVID-19 patients. The expert panel from 27 countries and 6 continents with considerable experience of direct application of PoCUS on COVID-19 patients presents evidence-based consensus using GRADE methodology for the quality of evidence and an expedited, modified-Delphi process for the strength of expert consensus...
December 24, 2020: Critical Care: the Official Journal of the Critical Care Forum
#20
JOURNAL ARTICLE
Barbara Pasculli, Raffaela Barbano, Andrea Fontana, Tommaso Biagini, Maria Pia Di Viesti, Michelina Rendina, Vanna Maria Valori, Maria Morritti, Sara Bravaccini, Sara Ravaioli, Evaristo Maiello, Paolo Graziano, Roberto Murgo, Massimiliano Copetti, Tommaso Mazza, Vito Michele Fazio, Manel Esteller, Paola Parrella
miR-155-5p is a well-known oncogenic microRNA, showing frequent overexpression in human malignancies, including breast cancer. Here, we show that high miR-155-5p levels are associated with unfavorable prognostic factors in two independent breast cancer cohorts (CSS cohort, n = 283; and TCGA-BRCA dataset, n = 1,095). Consistently, miR-155-5p results as differentially expressed in the breast cancer subgroups identified by the surrogate molecular classification in the CSS cohort and the PAM50 classifier in TCGA-BRCA dataset, with the TNBC and HER2 -amplified tumors carrying the highest levels...
2020: Frontiers in Oncology
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