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Roberto copetti

Daniele Orso, Nicola Guglielmo, Nicola Federici, Francesco Cugini, Alessio Ban, Filippo Mearelli, Roberto Copetti
PURPOSE: Dehydration is a very common condition among elderly people. Till date there is not yet a fast and easy method to determine a state of dehydration in the emergency department. In the literature there are some exploratory studies that have tried to establish the relationship between some widely used laboratory values and ultrasound for the purpose of diagnosing dehydration. The primary aim of this study is to verify the correlation between two measures derived by ultrasound (caval index and expiratory diameter of inferior vena cava) and blood urea nitrogen (BUN)/creatinine ratio...
September 2016: Journal of Ultrasound
Luigi Cattarossi, Roberto Copetti, Giacomo Brusa, Stefano Pintaldi
Background. Pneumothorax (PTX) still remains a common cause of morbidity in critically ill and ventilated neonates. At the present time, lung ultrasound (LUS) is not included in the diagnostic work-up of PTX in newborns despite of excellent evidence of reliability in adults. The aim of this study was to compare LUS, chest X-ray (CXR), and chest transillumination (CTR) for PTX diagnosis in a group of neonates in which the presence of air in the pleural space was confirmed. Methods. In a 36-month period, 49 neonates with respiratory distress were enrolled in the study...
2016: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
Roberto Copetti
No abstract available.
May 2016: Acta Medica Academica
Roberto Copetti, Nicola Guglielmo
No abstract text is available yet for this article.
June 2016: Minerva Anestesiologica
Gianluigi Mazzoccoli, Giuseppe Miscio, Andrea Fontana, Massimiliano Copetti, Massimo Francavilla, Alberto Bosi, Federico Perfetto, Alice Valoriani, Angelo De Cata, Michele Santodirocco, Angela Totaro, Rosa Rubino, Lazzaro di Mauro, Roberto Tarquini
Umbilical cord blood (UCB) contains hematopoietic stem cells and multipotent mesenchymal cells useful for treatment in malignant/nonmalignant hematologic-immunologic diseases and regenerative medicine. Transplantation outcome is correlated with cord blood volume (CBV), number of total nucleated cells (TNC), CD34+ progenitor cells and colony forming units in UCB donations. Several studies have addressed the role of maternal/neonatal factors associated with the hematopoietic reconstruction potential of UCB, including: gestational age, maternal parity, newborn sex and birth weight, placental weight, labor duration and mode of delivery...
2016: Scientific Reports
Antonella Marucci, Claudia Menzaghi, Massimilano Copetti, Federica Vinciguerra, Roberto Baratta, Lucia Salvemini, Eleonora Morini, Lucia Frittitta, Rosa Di Paola, Vincenzo Trischitta
AIMS: Our aims were to investigate in several large samples, with a wide range of adiposity, whether: (1) the effect of BMI on insulin sensitivity is different between sexes; (2) also waist circumference plays a sex-specific role on insulin sensitivity; and (3) serum adiponectin and resistin are mediators of such sex-dimorphic effect. METHODS: Samples used were: Gargano study 1 (GS1), GS2 and Catania study (CS) comprising 3274 individuals. Adiponectin and resistin were measured by ELISA...
October 2015: Acta Diabetologica
Giacomo Brusa, Marilena Savoia, Michela Vergine, Andrea Bon, Roberto Copetti, Luigi Cattarossi
OBJECTIVES: To assess the reliability of lung sonography in neonates between physician interpreters with different degrees of experience. METHODS: We retrospectively reviewed lung sonograms from neonates admitted to a neonatal intensive care unit with respiratory distress in the first 24 hours of life. The first scans were selected; only patients with available video clips documenting both hemithoraxes were included. The clips were independently examined by 4 different experienced observers blinded to clinical data...
September 2015: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
Concetta Pirozzi, Fabio G Numis, Antonio Pagano, Paolo Melillo, Roberto Copetti, Fernando Schiraldi
BACKGROUND: Dyspnea is one of the most frequent complaints in the Emergency Department. Thoracic ultrasound should help to differentiate cardiogenic from non-cardiogenic causes of dyspnea. We evaluated whether the diagnostic accuracy can be improved by adding a point-of-care-ultrasonography (POC-US) to routine exams and if an early use of this technique produces any advantage. METHODS: One hundred sixty-eight patients were enrolled and randomized in two groups: Group 1 received an immediate POC-US in addition to routine laboratory and instrumental tests; group 2 received an ultrasound scan within 1 h from the admission to the Emergency Department...
2014: Critical Ultrasound Journal
Paola Parrella, Raffaela Barbano, Barbara Pasculli, Andrea Fontana, Massimiliano Copetti, Vanna Maria Valori, Maria Luana Poeta, Giuseppe Perrone, Daniela Righi, Marina Castelvetere, Michelina Coco, Teresa Balsamo, Maria Morritti, Fabio Pellegrini, Andrea Onetti-Muda, Evaristo Maiello, Roberto Murgo, Vito Michele Fazio
BACKGROUND: MicroRNA-10b (miR-10b) has a prominent role in regulating tumor invasion and metastasis by targeting the HOXD10 transcriptional repressor and has been found up-regulated in several tumor types. METHODS: We evaluated the expression of miR-10b in paired tumor and normal specimens obtained from a prospective cohort of breast cancer patients with at least 36 months follow-up enrolled according to the REMARK guidelines (n = 150). RNA quality was measured and only samples with RNA Integrity Number (RIN) ≥7...
2014: Molecular Cancer
Michela Vergine, Roberto Copetti, Giacomo Brusa, Luigi Cattarossi
BACKGROUND: Lung ultrasound (LUS) is a promising technique for the diagnosis of neonatal respiratory diseases. Preliminary data has shown a good sensitivity and specificity of LUS in the diagnosis of respiratory distress syndrome (RDS) and transient tachypnea of the newborn (TTN). OBJECTIVE: The aim of this study was to calculate the sensitivity, specificity, and negative (NPV) and positive predictive value (PPV) of LUS for RDS and TTN, using an external reader blinded to the clinical condition...
2014: Neonatology
Angelika Reissig, Roberto Copetti
Lung ultrasound (LUS) is an accurate tool for the diagnosis and follow-up of pneumonia in adults as well as in children. LUS is at least as accurate as chest radiography in diagnosing pneumonia. The most important parenchymal criterion is the positive air bronchogram within an echopoor area. Among pleural criteria, basal effusion was most often detected. The presence of multiple diffuse bilateral B-lines on lung examination indicates the interstitial syndrome (IS). For further differential diagnosis, an integrated consideration of history, clinical examination, LUS and echocardiography should be performed...
2014: Respiration; International Review of Thoracic Diseases
Andrea Smargiassi, Riccardo Inchingolo, Gino Soldati, Roberto Copetti, Giampietro Marchetti, Alessandro Zanforlin, Rosangela Giannuzzi, Americo Testa, Stefano Nardini, Salvatore Valente
Chest ultrasonography can be a useful diagnostic tool for respiratory physicians. It can be used to complete and widen the general objective examination also in emergency situations, at the patient's bedside. The aim of this document is to promote better knowledge and more widespread use of thoracic ultrasound among respiratory physicians in Italy.This document II is focused on advanced approaches to chest ultrasonography especially in diagnosing sonographic interstitial syndrome with physical hypotheses about the genesis of vertical artifacts, differential diagnosis of cardiogenic pulmonary edema and non-cardiogenic pulmonary edema, raising diagnostic suspicion of pulmonary embolism, ultrasound characterization of lung consolidations and the use of ultrasonography to guide procedural interventions in pulmonology...
2013: Multidisciplinary Respiratory Medicine
Alessandro Zanforlin, Rosangela Giannuzzi, Stefano Nardini, Americo Testa, Gino Soldati, Roberto Copetti, Giampietro Marchetti, Salvatore Valente, Riccardo Inchingolo, Andrea Smargiassi
Chest ultrasonography can be a useful diagnostic tool for respiratory physicians. It can be used to complete and widen the general objective examination also in emergency situations, at the patient's bedside. The aim of this document is to promote better knowledge and more widespread use of thoracic ultrasound among respiratory physicians in Italy. This document I is focused on basic knowledge of chest ultrasonography technique, physical basis, aims and characteristics, fields of application. Document I shows how chest ultrasonography can be useful to detect and monitor pleural diseases, pleural effusions and pneumothorax and how it can assess diaphragmatic kinetics and pathologies...
2013: Multidisciplinary Respiratory Medicine
Sabrina Prudente, Eleonora Morini, Lorella Marselli, Roberto Baratta, Massimiliano Copetti, Christine Mendonca, Francesco Andreozzi, Manisha Chandalia, Fabio Pellegrini, Diego Bailetti, Federica Alberico, Hetal Shah, Nicola Abate, Giorgio Sesti, Lucia Frittitta, Piero Marchetti, Alessandro Doria, Vincenzo Trischitta
CONTEXT: Reduced insulin signaling in insulin secreting β-cells causes defective insulin secretion and hyperglycemia in mice. OBJECTIVE: We investigated whether functional polymorphisms affecting insulin signaling (ie, ENPP1 K121Q, rs1044498; IRS1 G972R, rs1801278; and TRIB3 Q84R, rs2295490) exert a joint effect on insulin secretion and abnormal glucose homeostasis (AGH). DESIGN: Insulin secretion was evaluated by 1) the disposition index (DI) from an oral glucose tolerance test (OGTT) in 829 individuals; 2) insulin secretion stimulation index (SI) in islets from nondiabetic donors after glucose (n = 92) or glibenclamide (n = 89) stimulation...
June 2013: Journal of Clinical Endocrinology and Metabolism
Angelika Reissig, Christine Mempel, Ulrike Schumacher, Roberto Copetti, Florian Gross, Stefano Aliberti
BACKGROUND: The aim of this secondary analysis was to evaluate current microbiological approaches, microbiology, and antibiotic therapy in patients with community-acquired pneumonia (CAP) and acute exacerbation of chronic obstructive pulmonary disease (AECOPD) in clinical practice and to compare them with current international guidelines. METHODS: A total of 362 patients with suspected CAP were enrolled in 14 European centers in a prospective multicenter study. RESULTS: A total of 279 inpatients (CAP, n = 222; AECOPD, n = 57) were evaluated...
June 2013: Lung
Simonetta Bacci, Sabrina Prudente, Massimiliano Copetti, Belinda Spoto, Stefano Rizza, Roberto Baratta, Natalia Di Pietro, Eleonora Morini, Rosa Di Paola, Alessandra Testa, Francesca Mallamaci, Giovanni Tripepi, Yuan-Yuan Zhang, Luana Mercuri, Sara Di Silvestre, Renato Lauro, Lorenzo Malatino, Agostino Consoli, Fabio Pellegrini, Assunta Pandolfi, Lucia Frittitta, Carmine Zoccali, Massimo Federici, Alessandro Doria, Vincenzo Trischitta
OBJECTIVE: Insulin resistance (IR) and cardiovascular disease (CVD) share a common soil. We investigated the combined role of single nucleotide polymorphisms (SNPs) affecting insulin signaling (ENPP1 K121Q, rs1044498; IRS1 G972R, rs1801278; TRIB3 Q84R, rs2295490) on CVD, age at myocardial infarction (MI), in vivo insulin sensitivity and in vitro insulin-stimulated nitric oxide synthase (NOS) activity. DESIGN AND SETTING: 1. We first studied, incident cardiovascular events (a composite endpoint comprising myocardial infarction-MI, stroke and cardiovascular death) in 733 patients (2186 person-years, 175 events)...
January 2013: Atherosclerosis
Maria Luana Poeta, Emanuela Massi, Paola Parrella, Pasquale Pellegrini, Mariangela De Robertis, Massimiliano Copetti, Carla Rabitti, Giuseppe Perrone, Andrea Onetti Muda, Francesca Molinari, Elena Zanellato, Stefano Crippa, Damiano Caputo, Marco Caricato, Milo Frattini, Roberto Coppola, Vito Michele Fazio
Epigenetic alterations, such as CpG islands methylation and histone modifications, are recognized key characteristics of cancer. Glycogenes are a group of genes which epigenetic status was found to be changed in several tumors. In this study, we determined promoter methylation status of the glycogene beta-1,4-galactosyltransferase 1 (B4GALT1) in colorectal cancer patients. Methylation status of B4GALT1 was assessed in 130 colorectal adenocarcinomas, 13 adenomas, and in paired normal tissue using quantitative methylation specific PCR (QMSP)...
December 2012: Genes, Chromosomes & Cancer
Massimiliano Don, Alfredo Barillari, Luigi Cattarossi, Roberto Copetti
No abstract text is available yet for this article.
January 2013: Acta Paediatrica
Roberto Copetti, Giampiero Mattei
No abstract text is available yet for this article.
2010: BMJ Case Reports
Angelika Reissig, Roberto Copetti, Gebhard Mathis, Christine Mempel, Andreas Schuler, Peter Zechner, Stefano Aliberti, Rotraud Neumann, Claus Kroegel, Heike Hoyer
BACKGROUND: The aim of this prospective, multicenter study was to define the accuracy of lung ultrasound (LUS) in the diagnosis of community-acquired pneumonia (CAP). METHODS: Three hundred sixty-two patients with suspected CAP were enrolled in 14 European centers. At baseline, history, clinical examination, laboratory testing, and LUS were performed as well as the reference test, which was a radiograph in two planes or a low-dose CT scan in case of inconclusive or negative radiographic but positive LUS findings...
October 2012: Chest
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