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https://www.readbyqxmd.com/read/28346993/artemisia-sieberi-besser-essential-oil-and-treatment-of-fungal-infections
#1
REVIEW
Mohaddese Mahboubi
A. sieberi essential oil has been used for treatment of hardly curable infectious ulcers in Middle East Medicine and has been famous due to its wormicide effects. In this review, we evaluated the potency of A. sieberi essential oil in treatment of fungal infections. We searched in PubMed Central, Science direct, Wiley, Springer, SID, and accessible books, reports, thesis. There is a lot of mixed information on chemical compositions of A. sieberi essential oil, but most articles reported α, β-thujones as the main components of essential oils...
March 22, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28344633/the-function-of-myostatin-in-the-regulation-of-fat-mass-in-mammals
#2
REVIEW
Bing Deng, Feng Zhang, Jianghui Wen, Shengqiang Ye, Lixia Wang, Yu Yang, Ping Gong, Siwen Jiang
Myostatin (MSTN), also referred to as growth and differentiation factor-8, is a protein secreted in muscle tissues. Researchers believe that its primary function is in negatively regulating muscle because a mutation in its coding region can lead to the famous double muscle trait in cattle. Muscle and adipose tissue develop from the same mesenchymal stem cells, and researchers have found that MSTN is expressed in fat tissues and plays a key role in adipogenesis. Interestingly, MSTN can exert a dual function, either inhibiting or promoting adipogenesis, according to the situation...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28344586/comparative-transcriptome-reveals-benzenoid-biosynthesis-regulation-as-inducer-of-floral-scent-in-the-woody-plant-prunus-mume
#3
Kai Zhao, Weiru Yang, Yuzhen Zhou, Jie Zhang, Yushu Li, Sagheer Ahmad, Qixiang Zhang
Mei (Prunus mume) is a peculiar woody ornamental plant famous for its inviting fragrance in winter. However, in this valuable plant, the mechanism behind floral volatile development remains poorly defined. Therefore, to explore the floral scent formation, a comparative transcriptome was conducted in order to identify the global transcripts specifying flower buds and blooming flowers of P. mume. Differentially expressed genes were identified between the two different stages showing great discrepancy in floral volatile production...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28343934/hitchhiker-s-guide-to-the-red-cell-storage-galaxy-omics-technologies-and-the-quality-issue
#4
REVIEW
Angelo D'Alessandro, Jerard Seghatchian
Red blood cell storage in the blood bank makes millions of units of available for transfusion to civilian and military recipients every year. From glass bottles to plastic bags, from anticoagulants to complex additives, from whole blood to leukocyte filtered packed red blood cells: huge strides have been made in the field of blood component processing and storage in the blood bank during the last century. Still, refrigerated preservation of packed red blood cells under blood bank conditions results in the progressive accumulation of a wide series of biochemical and morphological changes to the stored erythrocytes, collectively referred to as the storage lesion(s)...
March 9, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28343147/ethical-ramifications-of-the-paolo-macchiarini-case
#5
Jaime A Teixeira da Silva
The Paolo Macchiarini case has several ethical ramifications. Professor Macchiarini, formerly of the Karolinska Institutet (KI), became famous for the tracheal surgeries he conducted between 2008 and 2014. His rapid rise to fame was followed by an almost equally rapid fall from grace as official reports, articles in newspapers and television programmes revealed several aspects related to misconduct in his curriculum vitae, professional practices and publishing-related activity. Formal misconduct reports issued by four KI co-workers in late 2014, then again in 2016, coupled with social scandals, including the tricking of a famous US television newscaster into a false marriage, a previous arrest in Italy for apparent bribery, and acute narcissism, all tainted Macchiarini's legend...
March 15, 2017: Indian Journal of Medical Ethics
https://www.readbyqxmd.com/read/28342450/scientific-feuds-polemics-and-ad-hominem-arguments-in-basic-and-special-interest-genetics
#6
Elof Axel Carlson
Scientific disputes are commonly presented and settled in journal publications. Most are resolved by a weighing of evidence and new findings. In some cases the arguments are personal and in the form of ad hominem attacks on the personality or integrity of an author of a journal article. Many famous scientists (e.g., Galileo, Newton, and Hooke) used ad hominem arguments in responding to their critics. William Bateson, W.F.R. Weldon, William Castle, and H.J. Muller used ad hominem arguments in their publications until the end of World War I, when editorial policy of journals changed...
January 2017: Mutation Research
https://www.readbyqxmd.com/read/28337121/logo-effects-on-brand-extension-evaluations-from-the-electrophysiological-perspective
#7
Qian Shang, Guanxiong Pei, Shenyi Dai, Xiaoyi Wang
Brand extension typically has two strategies: brand name extension (BN) and brand logo extension (BL). The current study explored which strategy (BN or BL) better enhanced the success of dissimilar brand extension and product promotion in enterprises. Event-related potentials (ERPs) were used to investigate electrophysiological processes when subjects evaluated their acceptance of the brand extension using a combined picture of S1 and S2. S1 was a famous brand presented by two identity signs (brand name and brand logo)...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28335965/-turn-off-fluorescent-sensor-for-highly-sensitive-and-specific-simultaneous-recognition-of-29-famous-green-teas-based-on-quantum-dots-combined-with-chemometrics
#8
Li Liu, Yao Fan, Haiyan Fu, Feng Chen, Chuang Ni, Jinxing Wang, Qiaobo Yin, Qingling Mu, Tianming Yang, Yuanbin She
Fluorescent "turn-off" sensors based on water-soluble quantum dots (QDs) have drawn increasing attention owing to their unique properties such as high fluorescence quantum yields, chemical stability and low toxicity. In this work, a novel method based on the fluorescence "turn-off" model with water-soluble CdTe QDs as the fluorescent probes for differentiation of 29 different famous green teas is established. The fluorescence of the QDs can be quenched in different degrees in light of positions and intensities of the fluorescent peaks for the green teas...
April 22, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28335411/how-the-cobra-got-its-flesh-eating-venom-cytotoxicity-as-a-defensive-innovation-and-its-co-evolution-with-hooding-aposematic-marking-and-spitting
#9
Nadya Panagides, Timothy N W Jackson, Maria P Ikonomopoulou, Kevin Arbuckle, Rudolf Pretzler, Daryl C Yang, Syed A Ali, Ivan Koludarov, James Dobson, Brittany Sanker, Angelique Asselin, Renan C Santana, Iwan Hendrikx, Harold van der Ploeg, Jeremie Tai-A-Pin, Romilly van den Bergh, Harald M I Kerkkamp, Freek J Vonk, Arno Naude, Morné A Strydom, Louis Jacobsz, Nathan Dunstan, Marc Jaeger, Wayne C Hodgson, John Miles, Bryan G Fry
The cytotoxicity of the venom of 25 species of Old World elapid snake was tested and compared with the morphological and behavioural adaptations of hooding and spitting. We determined that, contrary to previous assumptions, the venoms of spitting species are not consistently more cytotoxic than those of closely related non-spitting species. While this correlation between spitting and non-spitting was found among African cobras, it was not present among Asian cobras. On the other hand, a consistent positive correlation was observed between cytotoxicity and utilisation of the defensive hooding display that cobras are famous for...
March 13, 2017: Toxins
https://www.readbyqxmd.com/read/28324955/identifying-important-regions-in-eeg-epilepsy-brain-networks
#10
Nantia D Iakovidou, Manolis Christodoulakis, Eleftherios S Papathanasiou, Savvas S Papacostas, Georgios D Mitsis
The human brain has been called the most complex object in the known universe and in many ways it constitutes the final frontier of science. Lately, the functional connectivity in human brain has been regarded and studied as a complex network using electroencephalography (EEG) signals. This means that the brain is studied as a connected system, where nodes represent different specialized brain regions and links or connections, represent communication pathways between the nodes. It is also fairly established that graph theory provides a variety of measures, methods and tools that can be useful to efficiently model, analyze and study an EEG network...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28320898/a-personal-historic-perspective-on-the-role-of-chloride-in-skeletal-and-cardiac-muscle
#11
REVIEW
Otto F Hutter
During the early decades of the last century, skeletal muscle was held to be impermeable to chloride ions. This theory, based on shaky grounds, was famously falsified by Boyle and Conway in 1941. Two decades later and onwards, the larger part of the resting conductance of skeletal muscle was found to be due to chloride ions, sensitive to the chemical environment, and to be time-and-voltage dependent. So, much of the groundwork for the physiological role of chloride ions in skeletal muscle was laid before the game-changing discovery of chloride channels...
March 2017: Physiological Reports
https://www.readbyqxmd.com/read/28317245/efficient-discovery-of-quality-control-markers-for-gastrodia-elata-tuber-by-fingerprint-efficacy-relationship-modelling
#12
Mingfang Li, Yuan Du, Long Wang, Lilong Jiang, Xiaodong Ma, Ping Zhou, Ping Li, Huijun Li
INTRODUCTION: Gastrodia elata tuber (GET) has been widely used in China as a famous herbal medicine. However, the quality control markers (QCMs) for GET still need further investigation. OBJECTIVE: To develop a rational strategy based on fingerprint-efficacy relationship modelling to discover the efficacy-related QCMs, using GET as a case study. METHODOLOGY: The high-performance liquid chromatography (HPLC) fingerprints of 13 batches of GET extracts were established and 10 common peaks were structurally characterised by HPLC coupled with quadrupole time-of-flight mass spectrometry (QTOF-MS)...
March 20, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28316614/image-classification-using-biomimetic-pattern-recognition-with-convolutional-neural-networks-features
#13
Liangji Zhou, Qingwu Li, Guanying Huo, Yan Zhou
As a typical deep-learning model, Convolutional Neural Networks (CNNs) can be exploited to automatically extract features from images using the hierarchical structure inspired by mammalian visual system. For image classification tasks, traditional CNN models employ the softmax function for classification. However, owing to the limited capacity of the softmax function, there are some shortcomings of traditional CNN models in image classification. To deal with this problem, a new method combining Biomimetic Pattern Recognition (BPR) with CNNs is proposed for image classification...
2017: Computational Intelligence and Neuroscience
https://www.readbyqxmd.com/read/28316209/-huxianweng-the-old-man-of-bottle-immortal-is-not-a-famous-doctor-in-the-eastern-han-dynasty
#14
B Li
The name Huxianweng appeared in the Ming yi lei an (Classified Medical Records of Famous Physicians) did not live in the Eastern Han. Moreover, all medical cases it collected were not belonged to him alone but the accumulation of many people in several periods. By textual investigation, the prototype of Huxianweng is Yin Fu who lived in Yizheng County, Jiangsu Province in the end of the Ming Dynasty. He had expertise in medical skills and high medical ethics, and was therefore loved by the residents deeply...
January 28, 2017: Zhonghua Yi Shi za Zhi, Chinese Journal of Medical History
https://www.readbyqxmd.com/read/28316051/pathogenic-multiple-antimicrobial-resistant-escherichia-coli-serotypes-in-recreational-waters-of-mumbai-india-a-potential-public-health-risk
#15
Aayushi Maloo, Abhay B Fulke, Najmuddin Mulani, Soniya Sukumaran, Anirudh Ram
Globally, coastal waters have emerged into a pool of antibiotic resistance genes and multiple antibiotic resistant microorganisms, and pathogenicity of these resistant microorganisms in terms of serotypes and virulence genes has made the environment vulnerable. The current study underscores the presence of multiple antibiotic resistant pathogenic serotypes and pathotypes of Escherichia coli, the predominant faecal indicator bacteria (FIB), in surface water and sediment samples of famous recreational beaches (Juhu, Versova, Mahim, Dadar, and Girgaon) of Mumbai...
March 18, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28315213/enzyme-linked-immunosorbent-assay-elisa
#16
George N Konstantinou
Food allergy is a public health concern especially after recognizing its constantly increased prevalence and severity. Despite careful reading of food ingredient statements, food allergic individuals may experience reactions caused by "hidden", "masked", or "contaminated" proteins that are known major allergens. Many techniques have been developed to detect even small traces of food allergens, for clinical or laboratory purposes. Enzyme-linked immunosorbent assay (ELISA) is one of the best validated and most routinely used immunoassay in allergy research, in allergy diagnosis in allergy-related quality control in various industries...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28303227/analysis-of-cordyceps-by-multi-column-liquid-chromatography
#17
Zhengming Qian, Shaoping Li
Cordyceps is a famous traditional Chinese medicine (TCM) that has been used in China for hundreds of years. In the present study a multi-column liquid chromatography (MC-LC) system was developed for the qualitative analysis of macromolecules and micromolecules in Cordyceps. The MC-LC system includes a size exclusion pre-column, a size exclusion column (SEC) and a reversed phase column (RP) which were controlled by column-switching valves. The sample was separated by the size exclusion pre-column into two fractions (macromolecules and micromolecules)...
March 2017: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/28297916/using-hamiltonian-control-to-desynchronize-kuramoto-oscillators
#18
Oltiana Gjata, Malbor Asllani, Luigi Barletti, Timoteo Carletti
Many coordination phenomena are based on a synchronization process, whose global behavior emerges from the interactions among the individual parts. Often in nature, such self-organized mechanism allows the system to behave as a whole and thus grounding its very first existence, or expected functioning, on such process. There are, however, cases where synchronization acts against the stability of the system; for instance in some neurodegenerative diseases or epilepsy or the famous case of Millennium Bridge where the crowd synchronization of the pedestrians seriously endangered the stability of the structure...
February 2017: Physical Review. E
https://www.readbyqxmd.com/read/28296559/the-irony-of-highly-effective-bacterial-therapy-of-a-patient-derived-orthotopic-xenograft-pdox-model-of-ewing-s-sarcoma-which-was-blocked-by-ewing-himself-80%C3%A2-years-ago
#19
Takashi Murakami, Tasuku Kiyuna, Kei Kawaguchi, Kentaro Igarashi, Arun S Singh, Yukihiko Hiroshima, Yong Zhang, Ming Zhao, Kentaro Miyake, Scott D Nelson, Sarah M Dry, Yunfeng Li, Jonathan C DeLong, Thinzar M Lwin, Takashi Chishima, Kuniya Tanaka, Michael Bouvet, Itaru Endo, Fritz C Eilber, Robert M Hoffman
William B. Coley developed bacterial therapy of cancer more than 100 years ago and had clinical success. James Ewing, a very famous cancer pathologist for whom the Ewing sarcoma is named, was Coley's boss at Memorial Hospital in New York and terminated Coley's bacterial therapy of cancer. A tumor from a patient with soft-tissue Ewing's sarcoma, who failed doxorubicin (DOX) therapy, was previously implanted in nude mice to establish a patient-derived orthotopic xenograft (PDOX) model. In the present study, the Ewing's sarcoma PDOX was treated with tumor-targeting S...
March 15, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28294041/tacrine-based-multifunctional-agents-in-alzheimer-s-disease-an-old-story-in-continuous-development
#20
Andrea Milelli, Angela De Simone, Nicole Ticchi, Huan Huan Chen, Nibal Betari, Vincenza Andrisano, Vincenzo Tumiatti
Tacrine is no longer used for the treatment of Alzheimer's disease (AD) as oral acetylcholinesterase (AChE) inhibitor (AChEI) mainly due to its hepatotoxic effects. Notwithstanding, it is still one of the most famous drugs. Indeed, since the discovery of the "non-cholinergic" AChE's activities and the seminal paper from Pang and coworkers reporting the discovery of a tacrine-dimer, bis(7)-tacrine, tacrine has been used from legions of medicinal chemists as a starting point to develop new multi target ligands (MTLs), able to interfere with biochemical pathways and targets whose dysregulation seems to be involved in the development of AD...
March 9, 2017: Current Medicinal Chemistry
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