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https://www.readbyqxmd.com/read/28821095/an-o-acetyl-glucomannan-from-the-rhizomes-of-curculigo-orchioides-structural-characterization-and-anti-osteoporosis-activity-in-vitro
#1
Xueqian Wang, Mengliu Zhang, Dawei Zhang, Shumei Wang, Chunyan Yan
Osteoporosis is characterized by a reduction in bone mass and bone mineral density, which weakens the bone. Due to the side effects associated with drugs that are currently used to treat this disease, an increasing number of studies have focused on the research of effective ingredients derived from natural products. In particular, polysaccharides extracted from Chinese herbal medicines have received increasing attention. In this study, we isolated a homogeneous polysaccharide (COP90-1) from the dried rhizomes of Curculigo orchioides, a famous traditional Chinese medicine that is widely used in China, and determined its structure using the combined methods of chemical and spectral analyses...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28818861/auxin-signaling
#2
Ottoline Leyser
Auxin acts as a general co-ordinator of plant growth and development, transferring information over both long and short ranges. Auxin famously appears to be extraordinarily multi-functional, with different cells responding very differently to changes in auxin levels. There has been considerable progress over recent years in understanding how this complexity is encoded in the cellular auxin response machinery. Of central importance is an elegantly short but versatile signaling pathway through which auxin triggers changes in gene expression...
August 17, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28815746/matthew-baillie-s-specimens-and-engravings
#3
Caitlin Spear, Maggie Reilly, Stuart W McDonald
In 1799, Matthew Baillie, William Hunter's nephew, published his famous atlas of pathology. It was entitled A Series of Engravings Accompanied with Explanations which are Intended to Illustrate the Morbid Anatomy of Some of the Most Important Parts of the Human Body. The present study aims to match the illustrations to extant specimens in the collections of William and John Hunter, preserved at the University of Glasgow and at the Royal College of Surgeons of England respectively. Baillie's book contains 10 fasciculi, consisting of 73 plates and 206 figures...
August 17, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28813091/guillain-barr%C3%A3-syndrome-celebrating-a-century
#4
Marcos R G de Freitas, Cecília M Vidal, Marco Orsini
A hundred years ago, Guillain, Barré and Strohl described a syndrome with a predominant motor acute or subacute polyneuritis, albumin-cytologic dissociation in the cerebrospinal fluid, and a benign course. Before them, many other authors, such as Landry, Duménil, Osler, and Grainger Stewart had described similar cases although they had not performed lumbar punctures. In this work, we outline certain features of the beginning of this famous syndrome.
August 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/28805767/-w-griesinger-a-famous-european-psychiatrist-the-200-anniversary-of-birth
#5
S A Ovsyannikov, A S Ovsyannikov
The article contains curriculum vitae of W. Griesinger and an analysis of the clinical-psychopathological approach developed by him for studying illnesses and their systematization. The stages of psychosis' progression in dynamics are shown. A clinical description of primary emerged dementia made by W. Griesinger as well as a description of the status of Grubelsucht, first discovered by the psychiatrist, are presented. The article emphasizes W. Griesinger' priority in the determination of reflexes' exclusive role in the appearance and further development of all types of mental disorders...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28805738/vibroacoustic-impact-on-the-architectonic-heritage-when-using-replicas-of-16th-century-weapons
#6
Angel Tomas Lloret, Sandra Sendra, Jaime Lloret, Romina Del Rey, Miguel Louis Cereceda
The recreation of historical battles next to old buildings, walls, churches, fortifications or historical facades belonging to the historical heritage of a city, has always been a source of controversy and discussion. In the absence of a clear legislation about how these buildings can be affected by the use of blunderbusses and pyrotechnics, it is necessary to carry out practical experiments to test the effect of these celebrations on these buildings. For this reason, this paper presents a set of practical experiments where the vibroacoustic effect of using weapons such as blunderbusses and harquebuses is analyzed...
August 14, 2017: Sensors
https://www.readbyqxmd.com/read/28805696/licochalcone-a-inhibits-the-proliferation-of-human-lung-cancer-cell-lines-a549-and-h460-by-inducing-g2-m-cell-cycle-arrest-and-er-stress
#7
Chenyu Qiu, Tingting Zhang, Wenxin Zhang, Lina Zhou, Bin Yu, Wei Wang, Zhihong Yang, Zhiguo Liu, Peng Zou, Guang Liang
Licochalcone A (LicA), a flavonoid isolated from the famous Chinese medicinal herb Glycyrrhiza uralensis Fisch, has wide spectrum of pharmacological activities. In this study, the anti-cancer effects and potential mechanisms of LicA in non-small cell lung cancer (NSCLC) cells were studied. LicA decreased cell viability and induced apoptosis in a dose-dependent manner in NSCLC cells. LicA inhibited lung cancer cells growth by blocking cell cycle progression at the G2/M transition and inducing apoptosis. LicA treatment decreased the expression of MDM2, Cyclin B1, Cdc2 and Cdc25C in H460 and A549 cancer cell lines...
August 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28804857/nobel-prize-nominees-hundred-years-ago-abraham-jacobi-1830-1919-and-otto-heubner-1843-1926
#8
Nils Hansson, Anne Oommen-Halbach, Arndt Borkhardt, Heiner Fangerau
Pediatrics directly and indirectly played an important role in the history of the Nobel Prize in physiology or medicine. However, the history of the Nobel Prize and pediatrics goes beyond the actual laureates. Based on original files in the archive of the Nobel committee of physiology or medicine at the Karolinska Institute in Sweden, this overview aims to shed new light on why the international pioneers of pediatrics Abraham Jacobi (1830-1919) and Otto Heubner (1843-1926) were nominated but never received the prize in 1918...
August 13, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28802217/comparatively-evaluating-the-pharmacokinetic-of-fifteen-constituents-in-normal-and-blood-deficiency-rats-after-oral-administration-of-xin-sheng-hua-granule-by-uplc-ms-ms
#9
Han-Qing Pang, Yu-Ping Tang, Yu-Jie Cao, Ya-Jie Tan, Yi Jin, Xu-Qin Shi, Sheng-Liang Huang, Da-Zheng Sun, Jin Sun, Zhi-Shu Tang, Jin-Ao Duan
Xin-Sheng-Hua Granule (XSHG), a famous traditional Chinese medicine prescription, are clinically applied for the treatment of postpartum disease through nourishing blood and promoting blood circulation. In this investigation, a multi-constituents (trigonelline, stachydrine hydrochloride, hydroxysafflor yellow A, chlorogenic acid, amygdalin, leonurine, liquiritin, ferulic acid, senkyunolide I, senkyunolide H, glycyrrhizic acid, senkyunolide A, ligustilide, butylidenephthalide and glycyrrhetinic acid) pharmacokinetic study of XSHG was conducted for the first time...
July 30, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28801890/application-of-grading-of-recommendations-assessment-development-and-evaluation-grade-to-the-guideline-development-for-clinical-practice-with-acupuncture-and-moxibustion
#10
Hong Zhao, Fengxia Liang, Yigong Fang, Baoyan Liu
Grading of Recommendations Assessment, Development, and Evaluation (GRADE) offers a worldwide approach to guideline development for clinical practice. For the clinical practice of acupuncture therapy, 18 evidence-based guidelines have been developed in China using GRADE. In this study, we review the advantages and limitations of the GRADE approach in the guideline development for acupuncture and moxibustion and propose some solutions to these limitations. Scientific advantages of rating the quality of evidence, outcome-centric direction, overall progression to develop recommendations, and strength of recommendations providing specific clinical guidance are the advantages of GRADE...
August 12, 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/28794013/control-mechanisms-in-germ-cells-mediated-by-p53-family-proteins
#11
REVIEW
Jakob Gebel, Marcel Tuppi, Katharina Krauskopf, Daniel Coutandin, Susanne Pitzius, Sebastian Kehrloesser, Christian Osterburg, Volker Dötsch
Germ cells are totipotent and, in principle, immortal as they are the source for new germ cells in each generation. This very special role requires tight quality control systems. The p53 protein family constitutes one of the most important quality surveillance systems in cells. Whereas p53 has become famous for its role as the guardian of the genome in its function as the most important somatic tumor suppressor, p63 has been nicknamed 'guardian of the female germ line'. p63 is strongly expressed in resting oocytes and responsible for eliminating those that carry DNA double-strand breaks...
August 9, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28793198/preregistered-replication-of-affective-flexibility-evaluative-processing-goals-shape-amygdala-activity
#12
Daniel S Lumian, Kateri McRae
The human amygdala is sensitive to stimulus characteristics, and growing evidence suggests that it is also responsive to cognitive framing in the form of evaluative goals. To examine whether different evaluations of stimulus characteristics shape amygdala activation, we conducted a preregistered replication of Cunningham, Van Bavel, and Johnsen's (2008) study demonstrating flexible mapping of amygdala activation to stimulus characteristics, depending on evaluative goals. Participants underwent functional MRI scanning while viewing famous names under three conditions: They were asked to report their overall attitude toward each name, their positive associations only, or their negative associations only...
August 1, 2017: Psychological Science
https://www.readbyqxmd.com/read/28791557/ren%C3%A3-favaloro-the-heart-surgeon
#13
Massimo Fioranelli, Maria Grazia Roccia, Miriam Rovesti, Francesca Satolli, Paola Petrelli, Claudio Feliciani, Torello Lotti
The story of René Favaloro is almost unknown to the general public. Christian Barnard, the cardiac surgeon who performed the world's first human-to-human heart transplant, is much more famous than him; still, nowadays many more lives are saved thanks to Favaloro's work rather than to heart transplants. This paper wants to pay tribute to a great doctor and an extraordinary man: René Favaloro.
August 8, 2017: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28783226/case-study-of-berengario-da-carpi-and-lorenzo-de-medici
#14
D Lippi
Jacopo Berengario da Carpi (c.1460-c.1530) made several important advances in anatomy, being universally considered the founder of 'animated anatomy' (anatomia animata). In addition to being a famous anatomist, Berengario was also a highly regarded surgeon. One of his famous clients was Lorenzo de' Medici, Duke of Urbino (1492-1519). In 1517, Lorenzo suffered a skull injury from an harquebus shot and Berengario was asked to come to his bedside. Lorenzo's case gave Berengario the opportunity to write his Tractatus de Fractura Calve sive Cranei, published in Bologna by Gerolamo Benedetti in 1518...
September 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28782973/the-digitization-of-the-wundt-estate-at-leipzig-university
#15
Till Meyer, Andreas Mädebach, Erich Schröger
Wilhelm M. Wundt (1832-1920) was one of the most important German scholars of the 19th and early 20th centuries and famously founded the first institute for experimental psychology in Leipzig in 1879. Wundt's institute established a teaching and research facility that attracted a large number of students from all over the world and contributed greatly to the development of modern psychology. Until now, the relatively poor indexing and documentation as well as the difficulty in accessing the Wundt estate has prevented a widespread and comprehensive investigation and consideration of these documents...
August 2017: History of Psychology
https://www.readbyqxmd.com/read/28782622/banxia-houpu-decoction-restores-glucose-intolerance-in-cums-rats-through-improvement-of-insulin-signaling-and-suppression-of-nlrp3-inflammasome-activation-in-liver-and-brain
#16
Ke-Ke Jia, Yan-Jing Zheng, Yan-Xiu Zhang, Jia-Hui Liu, Rui-Qing Jiao, Ying Pan, Ling-Dong Kong
ETHNOPHARMACOLOGICAL RELEVANCE: Banxia-houpu decoction is a famous formula in traditional Chinese medicine (TCM) with the powerful anti-depressant activity. AIM OF THE STUDY: This study aimed to investigate the effect of Banxia-houpu decoction on glucose intolerance associated with anhedonia in chronic unpredictable mild stress (CUMS) rats, then to explore its underlying pharmacological mechanisms. MATERIALS AND METHODS: After 6-week CUMS procedure, male Wistar rats were given Banxia-houpu decoction (3...
August 4, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28773098/finite-element-analysis-of-interfacial-debonding-in-copper-diamond-composites-for-thermal-management-applications
#17
Muhammad Zain-Ul-Abdein, Hassan Ijaz, Waqas Saleem, Kabeer Raza, Abdullah Salmeen Bin Mahfouz, Tarek Mabrouki
Copper/diamond (Cu/D) composites are famous in thermal management applications for their high thermal conductivity values. They, however, offer some interface related problems like high thermal boundary resistance and excessive debonding. This paper investigates interfacial debonding in Cu/D composites subjected to steady-state and transient thermal cyclic loading. A micro-scale finite element (FE) model was developed from a SEM image of the Cu/20 vol % D composite sample. Several test cases were assumed with respect to the direction of heat flow and the boundary interactions between Cu/uncoated diamonds and Cu/Cr-coated diamonds...
July 2, 2017: Materials
https://www.readbyqxmd.com/read/28769836/familiarity-and-voice-representation-from-acoustic-based-representation-to-voice-averages
#18
Maureen Fontaine, Scott A Love, Marianne Latinus
The ability to recognize an individual from their voice is a widespread ability with a long evolutionary history. Yet, the perceptual representation of familiar voices is ill-defined. In two experiments, we explored the neuropsychological processes involved in the perception of voice identity. We specifically explored the hypothesis that familiar voices (trained-to-familiar (Experiment 1), and famous voices (Experiment 2)) are represented as a whole complex pattern, well approximated by the average of multiple utterances produced by a single speaker...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28764007/formation-and-emission-of-linalool-in-tea-camellia-sinensis-leaves-infested-by-tea-green-leafhopper-empoasca-matsumurasca-onukii-matsuda
#19
Xin Mei, Xiaoyu Liu, Ying Zhou, Xiaoqin Wang, Lanting Zeng, Xiumin Fu, Jianlong Li, Jinchi Tang, Fang Dong, Ziyin Yang
Famous oolong tea (Oriental Beauty), which is manufactured by tea leaves (Camellia sinensis) infected with tea green leafhoppers, contains characteristic volatile monoterpenes derived from linalool. This study aimed to determine the formation mechanism of linalool in tea exposed to tea green leafhopper attack. The tea green leafhopper responsible for inducing the production of characteristic volatiles was identified as Empoasca (Matsumurasca) onukii Matsuda. E. (M.) onukii attack significantly induced the emission of linalool from tea leaves (p<0...
December 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28761789/an-exceptionally-preserved-110-million-years-old-praying-mantis-provides-new-insights-into-the-predatory-behaviour-of-early-mantodeans
#20
Marie K Hörnig, Joachim T Haug, Carolin Haug
Mantodeans or praying mantises are flying insects and well known for their raptorial behaviour, mainly performed by their first pair of thoracic appendages. We describe here a new, exceptionally preserved specimen of the early mantodean Santanmantis axelrodi Grimaldi, 2003 from the famous 110 million years old Crato Formation, Brazil. The incomplete specimen preserves important morphological details, which were not known in this specific form before for this species or any other representative of Mantodea. Unlike in modern representatives or other fossil forms of Mantodea not only the first pair of thoracic appendages shows adaptations for predation...
2017: PeerJ
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