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https://www.readbyqxmd.com/read/29241108/the-efficacy-of-posterior-hemivertebra-resection-with-lumbosacral-fixation-and-fusion-in-the-treatment-of-congenital-scoliosis-a-more-than-2-year-follow-up-study
#1
Qiunan Lyu, Bowen Hu, Chunguang Zhou, Limin Liu, Yueming Song, Xi Yang, Liang Wang, Lei Wang
OBJECTIVE: Hemivertebrae (HV) located at the lower lumbar or lumbosacral region often produce early trunk imbalance and long compensatory curves. Because of the biomechanical characteristics of the lumbosacral junction, the rate of instrumentation failures at the region has always been high. Our study aimed to evaluate the results of posterior HV resection with lumbosacral fixation and fusion in the treatment of congenital scoliosis and to make a preliminary analysis of the possible risk factors for instrument failures...
December 9, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29241041/inhibiting-the-plasmodium-eif2%C3%AE-kinase-pk4-prevents-artemisinin-induced-latency
#2
Min Zhang, Julio Gallego-Delgado, Cristina Fernandez-Arias, Norman C Waters, Ana Rodriguez, Moriya Tsuji, Ronald C Wek, Victor Nussenzweig, William J Sullivan
Artemisinin and its derivatives (ARTs) are frontline antimalarial drugs. However, ART monotherapy is associated with a high frequency of recrudescent infection, resulting in treatment failure. A subset of parasites is thought to undergo ART-induced latency, but the mechanisms remain unknown. Here, we report that ART treatment results in phosphorylation of the parasite eukaryotic initiation factor-2α (eIF2α), leading to repression of general translation and latency induction. Enhanced phosphorylated eIF2α correlates with high rates of recrudescence following ART, and inhibiting eIF2α dephosphorylation renders parasites less sensitive to ART treatment...
December 13, 2017: Cell Host & Microbe
https://www.readbyqxmd.com/read/29240754/maternal-death-review-and-outcomes-an-assessment-in-lagos-state-nigeria
#3
Friday Okonofua, Donald Imosemi, Brian Igboin, Adegboyega Adeyemi, Chioma Chibuko, Adewale Idowu, Wilson Imongan
The objective of the study was to investigate the results of Maternal and Perinatal Death Surveillance and Response (MPDSR) conducted in three referral hospitals in Lagos State, Nigeria over a two-year period and to report the outcomes and the lessons learned. MPDRS panels were constituted in the three hospitals, and beginning from January 2015, we conducted monthly MPDSR in the three hospitals using a nationally approved protocol. Data on births and deaths and causes of deaths as identified by the MPDSR panels were collated in the hospitals...
2017: PloS One
https://www.readbyqxmd.com/read/29240302/correlation-between-sinus-and-lung-cultures-in-lung-transplant-patients-with-cystic-fibrosis
#4
Kevin J Choi, Tracy Z Cheng, Adam L Honeybrook, Alice L Gray, Laurie D Snyder, Scott M Palmer, Ralph Abi Hachem, David W Jang
BACKGROUND: Lung transplantation has revolutionized the treatment of end-stage pulmonary disease due to cystic fibrosis. However, infection of the transplanted lungs can lead to serious complications, including graft failure and death. Although many of these patients have concurrent sinusitis, it is unclear whether bacteria from the sinuses can infect the allograft. METHODS: This is a single-institution retrospective study of all patients who underwent lung transplantation for cystic fibrosis from 2005 to 2015 at Duke University Hospital...
December 14, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29240293/transvenous-pacemaker-implantation-after-the-bidirectional-glenn-operation-for-patients-with-complex-congenital-disease
#5
Danielle E Harake, Kevin M Shannon, Jamil A Aboulhosn, Jeremy P Moore
INTRODUCTION: The bidirectional Glenn operation for congenital heart disease produces anatomical constraints to conventional transvenous pacemaker implantation. An iliac approach, although not previously described in this population, is potentially a preferable alternative to a thoracotomy for epicardial pacing. METHODS AND RESULTS: A single-center retrospective review was performed for all patients that underwent transvenous pacemaker implantation following the bidirectional Glenn operation with partial biventricular repair...
December 14, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29240058/-venous-thromboembolic-complications-in-patients-with-cardiovascular-implantable-electronic-devices
#6
R E Kalinin, I A Suchkov, I I Shitov, N D Mzhavanadze, V O Povarov
The problem of venous thromboembolic complications (VTECs) in patients with cardiovascular implantable electronic devices (CIEDs) is extremely important today because of an annually increasing number of surgical interventions for life-threatening arrhythmias and chronic heart failure. There are hitherto no clearly defined reliable risk factors for VTECs due to heterogeneity of the available literature data. Some sources point to elevated thrombus formation in patients with a large number of electrodes, in repeat operative interventions, in the presence of a temporary pacemaker, in implantation on the left side, silicon cover of an electrode, others refute these facts...
2017: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/29240041/reduction-of-excavation-face-collapse-risk-in-tunnelling
#7
Filippo Ariani, Alberto Baldasseroni, Alessandro Muller, Marco Biffino, Alessandro Matteucci
Two large road tunnels, recently developed near Florence, showed instabilities of the excavation face which subsequently caused sixteen collapses. Due to the risk for workers' safety, the public authority for occupational health and safety (ASL) has monitored the failure rate and other background variables in order to assess the possible correlations between risk reductions, its own actions, and those of the various safety actors involved. OBJECTIVES: To evaluate if the interventions carried out by the design team were able to reduce the risks of collapse and which of the ASL actions and/or which other factors were more effective in changing the attitudes of the parties involved, leading to a more expensive but safer project variant...
December 14, 2017: La Medicina del Lavoro
https://www.readbyqxmd.com/read/29240027/congenital-hemophilia-a-presenting-with-hashimoto-s-encephalopathy-and-myocarditis-the-first-reported-case
#8
Ayse B Ergul, Yasemin Altuner Torun, Umut Altug, Fatma T Mutlu, Serkan F Celik, Ahmet S Guven
Here, we report a case of hemophilia A with myocarditis, encephalopathy, and spontaneous intramedullary hemorrhage. A 14-month-old male infant presented with loss of consciousness, generalized tonic-clonic convulsions, and cardiac failure. The neurological examination was normal. Myocarditis was diagnosed. After administration of fresh frozen plasma, the aPTT did not return to normal. The factor VIII (FVIII) level was 10.2% the normal level, and the patient was diagnosed with hemophilia A. The cerebrospinal fluid (CSF) evaluation was unremarkable, with the exception of elevated CSF protein levels...
December 12, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29239349/influences-of-ivabradine-treatment-on-serum-levels-of-cardiac-biomarkers-sst2-gdf-15-supar-and-h-fabp-in-patients-with-chronic-heart-failure
#9
Peter Jirak, Dzeneta Fejzic, Vera Paar, Bernhard Wernly, Rudin Pistulli, Ilonka Rohm, Christian Jung, Uta C Hoppe, P Christian Schulze, Michael Lichtenauer, Atilla Yilmaz, Daniel Kretzschmar
Chronic heart failure (CHF) represents a major cause of hospitalization and death. Recent evidence shows that novel biomarkers such as soluble suppression of tumorigenicity (sST2), growth-differentiation factor-15 (GDF-15), soluble urokinase plasminogen activator receptor (suPAR) and heart-type fatty acid binding protein (H-FABP) are correlated with inflammatory and ischemic responses in CHF patients. In this study we examined the effects of Ivabradine that inhibited the hyperpolarization-activated cyclic nucleotide-gated channel (HCN channel, also called funny current If), thereby leading to selective heart rate reduction and improved myocardial oxygen supply on the cardiac biomarkers sST2, GDF-15, suPAR and H-FABP in 50 CHF patients at the University Hospital of Jena...
December 14, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29238946/papp-a2-a-new-key-regulator-of-growth
#10
Magdalena Banaszak-Ziemska, Marek Niedziela
Short stature is the main problem that paediatric endocrinologists have to grapple with. Endocrine disorders account for only 5% of patients with short stature, but this is still one of the most common causes of reports to the endocrine clinic and hospitalisation in the endocrine department. A properly functioning growth hormone/insulin-like growth factor (GH/IGF) axis is one of the most important factors in proper growth. A lot of genetic defects in this axis lead to syndromes marked by impaired growth, like Laron syndrome, muta-tions in the STAT5B, insulin-like growth factor 1 (IGF1), and insulin-like growth factor 1 receptor (IGF1R) and mutations in the acid labile subunit (ALS)...
2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/29238427/hiv-associated-nephropathy-in-africa-pathology-clinical-presentation-and-strategy-for-prevention
#11
REVIEW
Nazik Elmalaika Husain, Mohamed H Ahmed, Ahmed O Almobarak, Sufian K Noor, Wadie M Elmadhoun, Heitham Awadalla, Clare L Woodward, Dushyant Mital
The human immunodeficiency virus (HIV) infection can lead to progressive decline in renal function known as HIV-associated nephropathy (HIVAN). Importantly, individuals of African ancestry are more at risk of developing HIVAN than their European descent counterparts. An in-depth search on Google Scholar, Medline and PubMed was conducted using the terms "HIVAN" and "pathology and clinical presentation", in addition to "prevalence and risk factors for HIVAN", with special emphasis on African countries for any articles published between 1990 and 2017...
January 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29238218/breaking-the-cycle-cholesterol-cycling-and-synapse-damage-in-response-to-amyloid-%C3%AE
#12
Clive Bate
Soluble amyloid-β (Aβ) oligomers, a key driver of pathogenesis in Alzheimer disease, bind to cellular prion proteins (PrPC) expressed on synaptosomes resulting in increased cholesterol concentrations, movement of cytoplasmic phospholipase A2 (cPLA2) to lipid rafts and activation of cPLA2. The formation of Aβ-PrPC-cPLA2 complexes was controlled by the cholesterol ester cycle. Thus, Aβ activated cholesterol ester hydrolases which released cholesterol from stores of cholesterol esters; the increased cholesterol concentrations stabilised Aβ-PrPC-cPLA2 complexes...
2017: Journal of Experimental Neuroscience
https://www.readbyqxmd.com/read/29237359/safety-and-outcomes-of-ipsilateral-antegrade-angioplasty-for-femoropopliteal-disease
#13
James Cragg, Danielle Lowry, Jonathan Hopkins, David Parker, Mark Kay, Martin Duddy, Alok Tiwari
PURPOSE: Previous reports have suggested higher periprocedural complications after ipsilateral antegrade femoral arterial access (AA). We looked at a contemporary series comparing complication rates between AA and contralateral retrograde femoral arterial access (RA) for femoropopliteal angioplasty. METHOD: A prospective review of all cases between 2010 and 2015 in a United Kingdom tertiary vascular center. Demographical and procedural data were obtained for those undergoing percutaneous femoropopliteal angioplasty...
January 1, 2017: Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29237001/beneficial-effect-of-body-weight-control-on-left-ventricular-diastolic-function-in-the-general-population-an-analysis-of-longitudinal-data-from-a-health-check-up-clinic
#14
Seitetz C Lee, Masao Daimon, Marco R Di Tullio, Shunichi Homma, Takahiro Hasegawa, Sy Han Chiou, Tomoko Nakao, Megumi Hirokawa, Yoshiko Mizuno, Yutaka Yatomi, Tsutomu Yamazaki, Issei Komuro
Aims: Left ventricular (LV) diastolic dysfunction may lead to heart failure. A high body mass index (BMI) is associated with worse LV diastolic function. However, knowledge of the longitudinal relation between changes in BMI and LV diastolic function is limited. Methods and results: We retrospectively identified 165 asymptomatic individuals (aged 60 ± 10 years, 55% male) with preserved LV ejection fraction, who underwent repeated health check-ups (median interval: 365 days) at our hospital between 2009 and 2012...
December 11, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29236988/diagnostic-and-prognostic-value-of-myocardial-blood-flow-quantification-as-non-invasive-indicator-of-cardiac-allograft-vasculopathy
#15
Paco E Bravo, Brian A Bergmark, Tomas Vita, Viviany R Taqueti, Ankur Gupta, Sara Seidelmann, Thomas E Christensen, Michael T Osborne, Nishant R Shah, Nina Ghosh, Jon Hainer, Courtney F Bibbo, Meagan Harrington, Fred Costantino, Mandeep R Mehra, Sharmila Dorbala, Ron Blankstein, Akshay Desai, Lynne Stevenson, Michael M Givertz, Marcelo F Di Carli
Aims: Cardiac allograft vasculopathy (CAV) is a leading cause of death in orthotopic heart transplant (OHT) survivors. Effective non-invasive screening methods are needed. Our aim was to investigate the added diagnostic and prognostic value of myocardial blood flow (MBF) to standard myocardial perfusion imaging (MPI) with positron emission tomography (PET) for CAV detection. Methods and results: We studied 94 OHT recipients (prognostic cohort), including 66 who underwent invasive coronary angiography and PET within 1 year (diagnostic cohort)...
December 8, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29236944/transplantation-for-alcohol-related-liver-disease-is-it-fair
#16
Jessica L Mellinger, Michael L Volk
Aims: Alcohol-related liver disease (ALD) is the second leading cause of liver transplantation performed in the USA and Europe. We aimed to provide a narrative review of the major ethical issues governing transplantation for ALD. Methods: We performed a narrative review of the ethical concepts in organ allocation for ALD, including alcoholic hepatitis. Results: Ethical concerns regarding organ allocation for ALD involve issues of urgency, utility and justice...
December 11, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/29236513/depletion-of-airway-submucosal-glands-and-tp63-krt5-basal-cells-in-obliterative-bronchiolitis
#17
Anthony M Swatek, Thomas J Lynch, Adrianne K Crooke, Preston J Anderson, Scott R Tyler, Leonard Brooks, Marina Ivanovic, Julia A Klesney-Tait, Michael Eberlein, Tahuanty Pena, David K Meyerholz, John F Engelhardt, Kalpaj R Parekh
RATIONALE: Obliterative bronchiolitis (OB) is a major cause of mortality following lung transplantation. Depletion of airway stem cells (SCs) may lead to fibrosis in OB. OBJECTIVE: Two major SC compartments in airways are submucosal glands (SMGs) and surface airway TP63+(p63)/KRT5+(K5) basal cells (BCs). We hypothesized that depletion of these SC compartments occurs in OB. METHODS: Ferret orthotopic left lung transplants were used as an experimental model of OB, and findings were corroborated in human lung allografts...
December 13, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29235355/facile-fabrication-of-electrically-conductive-low-density-polyethylene-carbon-fiber-tubes-for-novel-smart-materials-via-multi-axial-orientation
#18
Yijun Li, Min Nie, Qi Wang
Electromechanical sensors are indispensable components in functional devices and robotics application. However, the fabrication of the sensors still maintain a challenging issue that high percolation threshold and easy failure of conductive network are derived from uniaxial orientation of conductive fillers in practical melt processing. Herein, we reported a facile fabrication method to prepare multi-axial low density polyethylene (LDPE) /carbon fibers (CFs) tube with bidirectional controllable electrical conductivity and sensitive strain-responsive performance via rotation extrusion technology...
December 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29235244/exercise-and-heart-failure-an-update
#19
REVIEW
Gaia Cattadori, Chiara Segurini, Anna Picozzi, Luigi Padeletti, Claudio Anzà
The present update is dedicated to the evolution of the interaction between heart failure (HF) and exercise and how the scientific community has handled it. Indeed, on the one hand, HF is a leading cause of morbidity and mortality with a stable prevalence from 1998 onward varying between 6.3% and 13.3%. On the other hand, exercise is seen as a diagnostic and prognostic tool as well as a therapeutic intervention in chronic HF. More precisely, the knowledge, the clinical application, and the research interest on the mutual interactions between exercise and HF have different phases in disease progression: Before HF onset (past): exercise provides protective benefit in preventing HF (primary prevention)...
December 13, 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/29234179/vitamin-e-coated-polysulfone-membrane-based-hemodiafiltration-attenuates-inflammation-in-a-rat-model-of-lipopolysaccharide-induced-systemic-inflammation
#20
Yoshihiro Hatanaka, Satoru Inoue, Koji Goto, Norihisa Yasuda, Seigo Hidaka, Takaaki Kitano
Background: Acute blood purification (ABP) therapy is used regularly in the clinical setting and reportedly alleviates organ failure associated with severe systemic inflammatory responses, leading to reduced mortality. The present study aimed to determine whether there is a difference in efficacy between polysulfone (PS) membranes, which are currently used regularly in the clinical setting, and vitamin E-coated polysulfone (VEPS) membranes, which are anticipated to exhibit the antioxidant and anti-inflammatory properties of vitamin E...
September 2017: Iranian Journal of Medical Sciences
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