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https://www.readbyqxmd.com/read/29928753/-medicaments-and-oral-healthcare-adverse-effects-of-medicines-and-self-care-products-on-the-gingiva
#1
C de Baat, P G M A Zweers, A Vissink
Medications and self care products may have adverse effects on the gingiva. These adverse effects can be divided into inflammation, intrinsic discolouration, irritation, trauma, cytotoxicity, lichenoid reaction, and proliferation. This article deals with the first 6 types of adverse effects mentioned: a subsequent article will deal with the last type mentioned. Since contraceptives were introduced, there have been indications that they cause or promote gingivitis, but with the current contraceptives this adverse effect is rarely seen...
June 2018: Nederlands Tijdschrift Voor Tandheelkunde
https://www.readbyqxmd.com/read/29928123/addictive-potential-of-novel-treatments-for-refractory-depression-and-anxiety
#2
REVIEW
Dusan Kolar
Treatment-resistant mood disorders and anxiety disorders require intensive treatment, but treatment options should balance benefits and adverse effects or other potential detrimental effects on patients, including the risk of developing prescription medication addiction. Some of the newer treatment modalities for mood and anxiety disorders may have similar properties to benzodiazepines. The goal of this review was to identify the potential for developing dependence on the novel treatment approaches to treatment-resistant depression and refractory anxiety disorders...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29927698/opioid-medications-in-expensive-formulations-are-sold-at-a-lower-price-than-immediate-release-morphine-in-countries-throughout-the-world-third-phase-of-opioid-price-watch-cross-sectional-study
#3
Liliana De Lima, Natalia Arias Casais, Roberto Wenk, Lukas Radbruch, Tania Pastrana
BACKGROUND: International Association for Hospice and Palliative Care implemented Opioid Price Watch (OPW) to monitor availability, dispensing prices and affordability of opioids. We found that opioids with complex delivery mechanisms [fentanyl transdermal (TD) patches, sustained-release (SR) morphine, and SR oxycodone] had lower dispensing prices than immediate-release (IR) morphine formulations. OBJECTIVE: Identify the extent that SR and TD formulations are dispensed at lower prices than generic IR morphine and the possible reasons to explain this observation...
June 21, 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29927625/roadside-survey-of-alcohol-and-drug-use-among-norwegian-drivers-in-2016-17-a-follow-up-of-the-2008-9-survey
#4
Håvard Furuhaugen, Ragnhild E G Jamt, Galina Nilsson, Vigdis Vindenes, Hallvard Gjerde
OBJECTIVE: To study the use of alcohol and drugs among the general driving population in the south-eastern part of Norway and to compare the findings with the results from a similar roadside survey in 2008-9. METHODS: A roadside survey of drivers of cars, vans, motorcycles and mopeds was performed from April 2016 to April 2017 in collaboration with the Mobile Police Service. Oral fluid was collected using the Quantisal device and analysed for alcohol, illicit drugs and psychoactive medicinal drugs...
June 21, 2018: Traffic Injury Prevention
https://www.readbyqxmd.com/read/29926944/periodontal-health-and-gingival-diseases-and-conditions-on-an-intact-and-a-reduced-periodontium-consensus-report-of-workgroup-1-of-the-2017-world-workshop-on-the-classification-of-periodontal-and-peri-implant-diseases-and-conditions
#5
Iain L C Chapple, Brian L Mealey, Thomas E Van Dyke, P Mark Bartold, Henrik Dommisch, Peter Eickholz, Maria L Geisinger, Robert J Genco, Michael Glogauer, Moshe Goldstein, Terrence J Griffin, Palle Holmstrup, Georgia K Johnson, Yvonne Kapila, Niklaus P Lang, Joerg Meyle, Shinya Murakami, Jacqueline Plemons, Giuseppe A Romito, Lior Shapira, Dimitris N Tatakis, Wim Teughels, Leonardo Trombelli, Clemens Walter, Gernot Wimmer, Pinelopi Xenoudi, Hiromasa Yoshie
Periodontal health is defined by absence of clinically detectable inflammation. There is a biological level of immune surveillance that is consistent with clinical gingival health and homeostasis. Clinical gingival health may be found in a periodontium that is intact, i.e. without clinical attachment loss or bone loss, and on a reduced periodontium in either a non-periodontitis patient (e.g. in patients with some form of gingival recession or following crown lengthening surgery) or in a patient with a history of periodontitis who is currently periodontally stable...
June 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29926804/2d-3d-buccal-epithelial-cell-self-assembling-as-a-tool-for-cell-phenotype-maintenance-and-fabrication-of-multilayered-epithelial-linings-i-in-vitro-i
#6
Irina Zurina, Anastasia Shpichka, Irina Saburina, Nastasia V Kosheleva, Anastasiya Gorkun, Ekaterina A Grebenik, Daria Kuznetsova, Deying Zhang, Yury Rochev, Denis Butnaru, Tatyana Zharikova, Elena Victorovna Istranova, Yuanyuan Zhang, Leonid Prokofievich Istranov, Peter S Timashev
Maintaining the epithelial status of cells in vitro and fabrication of a multilayered epithelial lining is one of the key problems in the therapy using cell technologies. When cultured in a monolayer, epithelial cells change their phenotype from epithelial to epithelial-mesenchymal or mesenchymal that makes it difficult to obtain a sufficient number of cells in a 2D culture and to use them in tissue engineering. Here, using buccal epithelial cells from the oral mucosa, we developed a novel approach to recover and maintain the stable cell phenotype and form a multilayered epithelial lining in vitro via the 2D/3D cell self-assembling...
June 21, 2018: Biomedical Materials
https://www.readbyqxmd.com/read/29926572/-lower-limb-venous-thrombosis-management-in-the-acute-phase
#7
M Sprynger
Venous thromboembolism is the third cardiovascular disease in Europe. The cornerstone of the treatment of deep vein thrombosis is anticoagulation. It aims at avoiding harmful complications : thrombosis extension and recurrence, pulmonary embolism and post-thrombotic syndrome. Due to low molecular weight heparins, and recently, to direct oral anticoagulants, most of the patients can get treatment as outpatients. Unfortunately, despite guideline publications, the management of these patients may be complicated in real life and not correspond to evidence-based medicine...
May 2018: Revue Médicale de Liège
https://www.readbyqxmd.com/read/29926499/periodontal-health-and-gingival-diseases-and-conditions-on-an-intact-and-a-reduced-periodontium-consensus-report-of-workgroup-1-of-the-2017-world-workshop-on-the-classification-of-periodontal-and-peri-implant-diseases-and-conditions
#8
Iain L C Chapple, Brian L Mealey, Thomas E Van Dyke, P Mark Bartold, Henrik Dommisch, Peter Eickholz, Maria L Geisinger, Robert J Genco, Michael Glogauer, Moshe Goldstein, Terrence J Griffin, Palle Holmstrup, Georgia K Johnson, Yvonne Kapila, Niklaus P Lang, Joerg Meyle, Shinya Murakami, Jacqueline Plemons, Giuseppe A Romito, Lior Shapira, Dimitris N Tatakis, Wim Teughels, Leonardo Trombelli, Clemens Walter, Gernot Wimmer, Pinelopi Xenoudi, Hiromasa Yoshie
Periodontal health is defined by absence of clinically detectable inflammation. There is a biological level of immune surveillance that is consistent with clinical gingival health and homeostasis. Clinical gingival health may be found in a periodontium that is intact, i.e. without clinical attachment loss or bone loss, and on a reduced periodontium in either a non-periodontitis patient (e.g. in patients with some form of gingival recession or following crown lengthening surgery) or in a patient with a history of periodontitis who is currently periodontally stable...
June 2018: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29925223/therapeutic-potential-of-the-rhizomes-of-anemarrhena-asphodeloides-and-timosaponin-a-iii-in-an-animal-model-of-lipopolysaccharide-induced-lung-inflammation
#9
Byung Kyu Park, Kyung Su So, Hye Jung Ko, Hyun Joong Kim, Ki Sun Kwon, Yong Soo Kwon, Kun Ho Son, Soon Youl Kwon, Hyun Pyo Kim
Investigations into the development of new therapeutic agents for lung inflammatory disorders have led to the discovery of plant-based alternatives. The rhizomes of Anemarrhena asphodeloides have a long history of use against lung inflammatory disorders in traditional herbal medicine. However, the therapeutic potential of this plant material in animal models of lung inflammation has yet to be evaluated. In the present study, we prepared the alcoholic extract and derived the saponin-enriched fraction from the rhizomes of A...
June 21, 2018: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/29925102/safety-and-toxicology-of-magnolol-and-honokiol
#10
Andrea Sarrica, Natalja Kirika, Margherita Romeo, Mario Salmona, Luisa Diomede
Magnolia officinalis and Magnolia obovata bark extracts have been used for thousands of years in Chinese and Japanese traditional medicines and are still widely employed as herbal preparations for their sedative, antioxidant, anti-inflammatory, antibiotic, and antispastic effects. Neolignans, particularly magnolol and honokiol, are the main substances responsible for the beneficial properties of the magnolia bark extract (MBE). The content of magnolol and honokiol in MBE depends on different factors, including the Magnolia plant species, the area of origin, the part of the plant employed, and the method used to prepare the extract...
June 20, 2018: Planta Medica
https://www.readbyqxmd.com/read/29924763/dental-status-salivary-flow-and-sociodemographic-aspects-in-sheehan-syndrome-patients
#11
D-D-S Cavalcante, A-R Pinto-Quidute, M-R Alves-Martins, A-S Walter-de-Aguiar, A-M-P Lima-Cid, P-G-B Silva, R-F Cavalcante, F-W-G Costa
BACKGROUND: Sheehan's syndrome (SS) is one of the leading causes of hypopituitarism in developing countries. It occurs after postpartum necrosis of the pituitary gland, and it is considered a significant public health problem. This paper, apparently unpublished, aimed to perform an analysis on oral aspects in patients with SS. MATERIAL AND METHODS: A cross-sectional study was performed with 23 women diagnosed with SS at the Division of Endocrinology and Diabetes (Walter Cantídio University Hospital, Fortaleza, Brazil)...
June 20, 2018: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29924761/recurrence-rate-of-odontogenic-keratocyst-treated-by-enucleation-and-peripheral-ostectomy-retrospective-case-series-with-up-to-12-years-of-follow-up
#12
Ç Karaca, K-A Dere, N Er, A Aktaş, E Tosun, O-T Köseoğlu, A Usubütün
BACKGROUND: Odontogenic keratocysts have been reported with high recurrence rates in the literature so various treatment modalities from simple enucleation to resection have been performed to achieve the cure. The purpose of this retrospective study was to investigate the recurrence rate of odontogenic keratocysts (OKCs) treated by enucleation and peripheral ostectomy. MATERIAL AND METHODS: An electronic search of the database of the Hacettepe University, Faculty of Medicine, Department of Pathology, was undertaken to identify patients histologically diagnosed with OKCs treated at Department of Oral and Maxillofacial Surgery between 2001 and 2015...
June 20, 2018: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29923612/the-construction-and-application-of-a-population-physiologically-based-pharmacokinetic-model-for-methadone-in-beagles-and-greyhounds
#13
Trevor Elwell-Cuddy, Miao Li, Butch KuKanich, Zhoumeng Lin
Methadone is an opioid analgesic in veterinary and human medicine. To help develop appropriate pain management practices and to develop a quantitative model for predicting methadone dosimetry, a flow-limited multiroute physiologically based pharmacokinetic (PBPK) model for methadone in dogs constructed with Berkeley Madonna™ was developed. The model accounts for intravenous (IV), subcutaneous (SC), and oral administrations, and compartmentalizes the body into different components. This model was calibrated from plasma pharmacokinetic data after IV administration of methadone in Beagles and Greyhounds...
June 20, 2018: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29923025/cannabinoids-for-treatment-of-ms-symptoms-state-of-the-evidence
#14
REVIEW
Jessica Rice, Michelle Cameron
PURPOSE OF REVIEW: Cannabis and cannabinoids have been used medically and recreationally for thousands of years and recently there has been a growing body of research in this area. With increased access now that medical marijuana is available in many jurisdictions, patients and providers want to know more about the evidence for benefits and risks of cannabinoid use. This paper provides an overview of the available cannabinoid-based formulations, a summary of the highest quality evidence for the use of cannabinoids for treating spasticity and pain associated with multiple sclerosis (MS), and a discussion of possible dosing regimens based on information from these studies...
June 19, 2018: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/29922588/toxic-effects-of-lambda-cyhalothrin-on-the-rat-thyroid-involvement-of-oxidative-stress-and-ameliorative-effect-of-ginger-extract
#15
Wael M Al-Amoudi
Lambda-cyhalothrin (LCT) is a synthetic pyrethroid that is widely used to control insecticide. Ginger is a traditional plant that is widely used as a spice or folk medicine. This study evaluates the antioxidant effect of ginger extract on thyroid toxicity induced by LCT in albino rats. Adult Rats were divided into 4 experimental groups: Group 1: control, Group 2: oral ginger treatment (24 mg/ml, 3 days/week for 4 weeks), Group 3: oral LCT treatment (1/100 LD50 , 3 days/week for 4 weeks), Group 4: oral LCT and ginger mixture treatment...
2018: Toxicology Reports
https://www.readbyqxmd.com/read/29921884/isoflavones-enhance-pharmacokinetic-exposure-of-active-lovastatin-acid-via-the-upregulation-of-carboxylesterase-in-high-fat-diet-mice-after-oral-administration-of-xuezhikang-capsules
#16
Dong Feng, Chun Ge, Zhao-Yi Tan, Jian-Guo Sun, Yuan Xie, Lan Yao, Cai-Xia Yan, Ji-Ye Aa, Guang-Ji Wang
Xuezhikang capsule (XZK) is a traditional Chinese medicine that contains lovastatin (Lv) for hyperlipidemia treatment, although it has fewer side effects than Lv. However, the pharmacokinetic mechanisms contributing to its distinct efficacy and low side effects are unclear. Mice were fed a high-fat diet (HFD) for 6 weeks to induce hyperlipidemia. We first conducted the pharmacokinetic studies in HFD mice following oral administration of Lv (10 mg/kg, i.g.) and found that HFD remarkably decreased the active form of Lv (the lovastatin acid, LvA) exposure in the circulation system, especially in the targeting organ liver, with a declined conversion from Lv to LvA, whereas the Lv (responsible for myotoxicity) exposure in muscle markedly increased...
June 19, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29921575/shen-shuai-ning-granule-decreased-serum-concentrations-of-indoxyl-sulfate-in-uremic-patients-undergoing-peritoneal-dialysis
#17
Xujiao Chen, Shouhong Gao, Mengna Ruan, Sixiu Chen, Jing Xu, Xiaohong Xing, Xiaohong Pan, Changlin Mei, Zhiguo Mao
Background Clearance of protein-bound uremic toxins (PBUTs) by dialysis is a challenge in the treatment of uremic patients. Shen-Shuai-Ning(SSN), a traditional Chinese medicine formulation, has been used commonly in China to retard kidney disease progression and decrease uremic toxins in chronic kidney disease patients, but the effects of SSN on serum PBUTs in dialysis patients were not investigated. Methods We conducted a randomized controlled trial in patients on peritoneal dialysis (PD) at dialysis center of Changzheng Hospital to evaluate the effects of SSN on serum PBUTs...
June 19, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29920710/moringa-oleifera-leaf-powder-alters-the-pharmacokinetics-of-amodiaquine-in-healthy-human-volunteers
#18
O S Olawoye, B A Adeagbo, O O Bolaji
WHAT IS KNOWN AND OBJECTIVE: Moringa oleifera (MO) Lam (Moringaceae) is commonly used as food supplement and as medicine in most African countries where malaria is also endemic. Therefore, co-administration of MO with antimalarials is a possibility. This study investigated the effects of MO leaves powder on the pharmacokinetics of amodiaquine (AQ) in human subjects. METHODS: Twenty healthy volunteers were recruited for the 3-period study. In the first period, a single dose of AQ tablet (10 mg/kg) was administered orally after an overnight fast...
June 19, 2018: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29920624/antihypertensive-effect-of-polyphenol-rich-fraction-of-azadirachta-indica-on-n%C3%AF-nitro-l-arginine-methyl-ester-induced-hypertension-and-cardiorenal-dysfunction
#19
Temidayo Olutayo Omóbòwálé, Ademola Adetokunbo Oyagbemi, Blessing Seun Ogunpolu, Olufunke Eunice Ola-Davies, Johnny Olufemi, Olukunle Ebunoluwa Racheal Asenuga, Temitayo Olabisi Ajibade, Olumuyiwa Abiola Adejumobi, Jeremiah Moyinoluwa Afolabi, Olufunke Olubunmi Falayi, Anofi Ashafa, Adeolu Alex Adedapo, Momoh Audu Yakubu
Azadirachta indica (AI) is a medicinal plant with reported antioxidant and cardio-protective properties. The use of plant-based polyphenols has become greatly increased in the last one decade. The present study investigated the protective effect of the polyphenol-rich fraction (PRF) of the methanol-extract of Azadirachta indica against Nω -Nitro-L-Arginine Methyl Ester (L-NAME) induced hypertension and cardiorenal dysfunction in rats. Fifty (50) Wistar albino rats were grouped into five groups. Group A, the control, was administered potable water...
June 19, 2018: Drug Research
https://www.readbyqxmd.com/read/29920360/sub-chronic-toxicity-of-gyejibokryeong-hwan-in-sprague-dawley-rats
#20
Seong Eun Jin, Chang-Seob Seo, Mee-Young Lee, Hyeun-Kyoo Shin, Mi-Jin Yang, Hyekyung Ha
ETHNOPHARMACOLOGICAL RELEVANCE: Traditional herbal formula Gyejibokryeong-hwan (GJBRH; Guizhifuling-wan, Keishibukuryo-gan) consisting five medicinal herbs has been used to treat uterine disorders, gynecological diseases and blood stasis syndrome in Asia. AIM OF THE STUDY: We evaluated the safety of GJBRH in Crl:CD Sprague-Dawley (SD) rats over a period of 13 weeks. MATERIALS AND METHODS: To confirm the stability of the components of GJBRH, we analyzed the component contents in GJBRH at different storage periods, using high-performance liquid chromatography...
June 16, 2018: Journal of Ethnopharmacology
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