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https://www.readbyqxmd.com/read/29454028/fabricating-3d-printed-orally-disintegrating-printlets-using-selective-laser-sintering
#1
Fabrizio Fina, Christine M Madla, Alvaro Goyanes, Jiaxin Zhang, Simon Gaisford, Abdul W Basit
Selective laser sintering (SLS) is a three-dimensional printing (3DP) technology employed to manufacture plastic, metallic or ceramic objects. The aim of this study was to demonstrate the feasibility of SLS to fabricating novel solid dosage forms with accelerated drug release properties, and with a view to create orally disintegrating formulations. Two polymers (hydroxypropyl methylcellulose (HPMC E5) and vinylpyrrolidone-vinyl acetate copolymer (Kollidon ® VA 64)) were separately mixed with 5% paracetamol (used as a model drug) and 3% Candurin ® gold sheen colorant; the powder mixes were subjected to SLS printing resulting in the manufacture of printlets (3DP tablets)...
February 14, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29453546/a-drosophila-model-to-decipher-the-toxicity-of-nanoparticles-taken-through-oral-routes
#2
S Aurosman Pappus, Monalisa Mishra
In recent era, nanoparticles (NPs) are widely used in food, medicine and body implants. Besides it's wide use being a foreign particle it may have some noxious effect on the body. To understand the mechanistic role of NPs toxicity, Drosophila appeared to be a superior model organism. Toxicity of several nanoparticles were accessed using Drosophila. The NPs, after oral route of exposure enter into the gut, crosses the barrier of peritrophic membrane and induces apoptosis. The toxicity of NPs within gut resulted in developmental delay, with decrease in pupa count, fly hatching along with weight loss...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29451672/predictors-of-persistent-prescription-opioid-analgesic-use-among-people-without-cancer-in-australia
#3
Samanta Lalic, Natasa Gisev, J Simon Bell, Maarit Jaana Korhonen, Jenni Ilomäki
AIMS: To identify patterns of opioid analgesic use and determine predictors of persistent opioid use among people without cancer. METHODS: A population-based cohort study of Australians initiating prescription opioids from July 2013 to December 2015 was conducted using data from a random 10% sample of people who accessed medicines through Australia's Pharmaceutical Benefits Scheme. A 12-month look-back period was used to define opioid initiation, exclude people with cancer, and determine comorbidities...
February 16, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29451510/-under-reporting-of-adverse-drug-reactions-a-problem-that-also-involves-medicines-subject-to-additional-monitoring-preliminary-data-from-a-single-center-experience-on-novel-oral-anticoagulants
#4
Anna Patrignani, Giorgia Palmieri, Nino Ciampani, Vincenzo Moretti, Antonio Mariani, Lucia Racca
BACKGROUND: Spontaneous reporting system is the most widely used method by pharmacovigilance centers. Its "voluntary nature" represents the main cause of adverse drug reaction (ADR) under-reporting phenomena. The aim of this study was to point out the issue of ADR under-reporting from doctors, particularly serious ADRs and adverse reactions caused by medicinal products subject to additional monitoring, such as novel oral anticoagulants (NOACs). METHODS: Only serious ADRs were analyzed, defined as death, life-threatening ADR, hospitalization (initial or prolonged), disability (significant or permanent), congenital anomaly...
January 2018: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/29451369/discovery-of-rogaratinib-bay-1163877-a-pan-fgfr-inhibitor
#5
Marie-Pierre Collin, Mario Lobell, Walter Hübsch, Dirk Brohm, Hartmut Schirok, Rolf Jautelat, Klemens Lustig, Ulf Bömer, Verena Vöhringer, Mélanie Héroult, Sylvia Grünewald, Holger Hess-Stumpp
Rogaratinib (BAY 1163877) is a highly potent and selective small-molecule pan-fibroblast growth factor receptor (FGFR) inhibitor (FGFR1-4) for oral application currently being investigated in phase 1 clinical trials for the treatment of cancer. In this publication, we report its discovery by de novo structure-based design and medicinal chemistry optimization together with its pharmacokinetic profile.
February 16, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29450736/health-and-quality-of-life-differ-between-community-living-older-people-with-and-without-remaining-teeth-who-recently-received-formal-home-care-a-cross-sectional-study
#6
A R Hoeksema, L L Peters, G M Raghoebar, H J A Meijer, A Vissink, A Visser
OBJECTIVE: To assess oral health, health, and quality of life (QoL) of care-dependent community-living older people with and without remaining teeth who recently received formal home care. MATERIALS AND METHODS: For this cross-sectional observational study, community-living older people (≥ 65 years), who recently (< 6 months) received formal home care, were interviewed with validated questionnaires and underwent an oral examination. Oral health, general health, medicines usage, frailty (Groningen Frailty Indicator), cognition (Minimal Mental State Examination), QoL (RAND 36), and oral health-related QoL (Oral Health Impact Profile-14) were assessed...
February 15, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29449328/cladribine-for-multiple-sclerosis
#7
(no author information available yet)
In the UK, there are twelve disease-modifying drugs licensed for various forms of multiple sclerosis (MS), of which three are oral therapies. An oral formulation of cladribine (Mavenclad - Merck Serono Europe Limited) was recently licensed by the European Medicines Agency (EMA) for the treatment of adult patients with highly active relapsing MS. 1,2 It is claimed to be "an innovatively simple approach" for treating this form of MS and "the only disease modifying therapy that can deliver and sustain 4 years of disease control with a maximum of 20 days oral treatment in the first 2 years...
February 2018: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/29449086/progress-in-the-use-of-dental-pulp-stem-cells-in-regenerative-medicine
#8
REVIEW
Eduardo Anitua, María Troya, Mar Zalduendo
The field of tissue engineering is emerging as a multidisciplinary area with promising potential for regenerating new tissues and organs. This approach requires the involvement of three essential components: stem cells, scaffolds and growth factors. To date, dental pulp stem cells have received special attention because they represent a readily accessible source of stem cells. Their high plasticity and multipotential capacity to differentiate into a large array of tissues can be explained by its neural crest origin, which supports applications beyond the scope of oral tissues...
February 12, 2018: Cytotherapy
https://www.readbyqxmd.com/read/29447319/squamous-cell-carcinoma-of-the-gingiva-mimicking-periodontal-disease-a-diagnostic-challenge-and-therapeutic-dilemma
#9
Michael M Bornstein, Claude Andreoni, Thomas Meier, Yiu Yan Leung
A case of squamous cell carcinoma of the gingiva (GSCC) in the left anterior maxilla in a 64-year-old woman that was treated for almost 5 years as suspected periodontal lesion prior to establishing the final diagnosis of oral cancer is presented in this case report. GSCCs have a variable clinical appearance, ranging from an exophytic mass to ulcerative lesions. They have been reported to pose a diagnostic challenge and are not infrequently initially misdiagnosed as periodontal disease. A delay in diagnosis and extraction of teeth in the vicinity of GSCCs has been demonstrated to increase the risk for lymph node metastasis and thus result in a lower 5-year survival rate...
March 2018: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/29446234/a-natural-antioxidant-tannic-acid-mitigates-iron-overload-induced-hepatotoxicity-in-swiss-albino-mice-through-ros-regulation
#10
Tapasree Basu, Sourav Panja, Anil Khushalrao Shendge, Abhishek Das, Nripendranath Mandal
Tannic acid (TA), a water soluble natural polyphenol with 8 gallic acids groups, is abundantly present in various medicinal plants. Previously TA has been investigated for its antimicrobial and antifungal properties. Being a large polyphenol, TA chelates more than 1 metal. Hence TA has been explored for potent antioxidant activities against reactive oxygen species (ROS), reactive nitrogen species (RNS) and as iron chelator in vitro thereby mitigating iron-overload induced hepatotoxicity in vivo. Iron dextran was injected intraperitoneally in Swiss albino mice to induce iron-overload triggered hepatotoxicity, followed by oral administration of TA for remediation...
February 15, 2018: Environmental Toxicology
https://www.readbyqxmd.com/read/29446222/engineering-controls-in-veterinary-oncology-a-survey-of-148-acvim-board-certified-oncologists-and-environmental-surveillance-in-20-specialty-hospitals
#11
K Alexander, N Northrup, D Clarke, H Lindell, T Laver
Engineering controls (EC, facility and equipment barriers between hazards and people) are used to avoid exposure to chemotherapy drugs. In this study, American College of Veterinary Internal Medicine board-certified veterinary oncologists were surveyed about their use of containment primary EC (C-PEC) and supplemental EC (closed system transfer devices, CSTD). The survey was completed by 148 (38%) of practicing diplomates. All used EC. Both C-PEC and CSTD were used at 92% of hospitals; however, US Pharmacopoeial Convention Chapter <800> (USP <800>) standards were met at only 19% of hospitals and oncologists did not know the type of C-PEC at 18% of hospitals...
February 15, 2018: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/29445842/-rare-diseases-in-dentistry-and-oral-medicine-report-on-the-2017-first-national-congress
#12
Marcel Hanisch, Susanne Jung, Johannes Kleinheinz
On November 25, the first national congress for rare diseases in dentistry and oral medicine under the auspices of ACHSE e. V. and Orphanet was held in Muenster. With speakers from the field of medicine, dentistry, politics, patient advocacy groups, self-help groups and persons concerned, a platform for exchange between physicians and patients on an equal footing was offered to the participants. At the end of each of the 12 lectures, more than 300 national and international guests discussed the various issues and perspectives related to the topic of rare diseases in dentistry and oral medicine...
February 14, 2018: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/29445633/the-effect-of-intensive-statin-therapy-on-symptomatic-intracranial-arterial-stenosis
#13
Peiyang Zhou, Zhihua Cao, Pu Wang, Guangzhi Liu, Xuan Yao, Puqing Wang, Guang Li, Guibin Zhang, Ping Gao
Background: The aim of this study was to observe the effect of intensive statin therapy on symptomatic intracranial arterial stenosis. Methods: overall, 120 patients with symptomatic intracranial arterial stenosis were admitted to the Xiangyang No.1 People's Hospital, Hubei University of Medicine, Xiangyang, China from January 2010 to May 2013. They were randomly divided into three groups and were given different doses of atorvastatin orally for 1 year or more, and followed up for 12 months...
February 2018: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/29444684/medicinal-plants-used-by-traditional-healers-to-treat-malignancies-and-other-human-ailments-in-dalle-district-sidama-zone-ethiopia
#14
Nigatu Tuasha, Beyene Petros, Zemede Asfaw
BACKGROUND: Medicinal plants (MPs) used by traditional healers (THs) were investigated in Megera and adjacent subdistricts (kebeles) of Dalle District, Sidama Zone, southern Ethiopia. The objective of the study was to identify and record MPs and their traditional uses in the treatment of various human ailments with emphasis on malignancies and other most frequently reported diseases. METHODS: Traditional medicinal knowledge held by 20 THs was investigated following standard ethnobotanical approaches...
February 14, 2018: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/29444611/the-effect-of-goreisan-on-the-prevention-of-chronic-subdural-hematoma-recurrence-multicenter-randomized-controlled-study
#15
Kosuke Katayama, Naoya Matsuda, Kiyohide Kakuta, Masato Naraoka, Atsuhito Takemura, Seiko Hasegawa, Kenichi Akasaka, Norihito Shimamura, Katsuhiro Itoh, Kenichiro Asano, Konno Hiromu, Hiroki Ohkuma
The relatively high rate of postoperative recurrence in the treatment of chronic subdural hematoma (CSDH) is a significant problem. Goreisan is an herbal medicine that exhibits a hydragogue effect by inhibiting the expression of aquaporins, and its efficacy in preventing postoperative CSDH recurrence has been suggested by several case trials. This multicenter, prospective, randomized controlled trial was performed to investigate the preventative effect of goreisan on postoperative CSDH recurrence. Patients with symptomatic CSDH over 60 years old undergoing burr hole surgery were enrolled in this study...
February 14, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29442094/a-potential-side-effect-of-oral-topical-steroids-central-serous-chorioretinopathy
#16
Saranya George, Anita Balan
Topical corticosteroids are some of the most common drugs used in oral medicine for treating atrophic and erosive lesions that affect the mucosa. Adverse effects of these drugs include oral candidiasis with associated burning mouth and hypogeusia, hypersensitive reactions to the drug, and inhibition of the hypothalamic-pituitary-adrenal axis and secondary adrenal insufficiency. The ocular side effects of oral topical steroids are less documented. This short communication describes a case of central serous retinopathy that developed following administration of oral topical steroid...
January 2018: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/29438774/palliative-effects-of-moringa-olifera-ethanolic-extract-on-hemato-immunologic-impacts-of-melamine-in-rats
#17
Yasmina M Abd-Elhakim, Khlood M El Bohi, Sahar Khalifa Hassan, Shorouk El Sayed, Sabry M Abd-Elmotal
Melamine (MEL) is a widespread food contaminant and adulterant. Moringa olifera is a widely known medicinal plant with various pharmacological properties. Herein, this study aimed to investigate, for the first time, the probable protective or therapeutic role of M. olifera ethanolic extract (MOE) against MEL induced hemato-immune toxic hazards. Fifty Sprague Dawely male rats were orally treated with distilled water, MOE (800 mg/kg bw), MEL (700 mg/kg bw), MOE/MEl or MOE + MEl. Erythrogram and leukogram profiling were evaluated to assess hematological status...
February 10, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29438178/treatment-of-pancreatic-cancer-with-intravenous-vitamin-c-a-case-report
#18
Jeanne A Drisko, Oscar K Serrano, Lisa R Spruce, Qi Chen, Mark Levine
Pancreatic ductal adenocarcinoma (PDA) has a dismal prognosis and is often discovered at an advanced stage with few therapeutic options. Current conventional regimens for PDA are associated with significant morbidity, decreased quality of life, and a considerable financial burden. As a result, some patients turn to integrative medicine therapies as an alternate option after a diagnosis of PDA. Intravenous pharmacologic ascorbic acid (PAA) is one such treatment. The use of PAA has been passionately debated for many years, but more recent rigorous scientific research has shown that there are significant blood concentration differences when ascorbic acid is given parenterally when compared to oral dosing...
February 12, 2018: Anti-cancer Drugs
https://www.readbyqxmd.com/read/29435870/chemopreventive-potential-of-esculetin-in-7-12-dimethylbenz-a-anthracene-induced-hamster-buccal-pouch-carcinogenesis
#19
Renganathan Selvasundaram, Shanmugam Manoharan, Rajamanickam Buddhan, Mani Neelakandan, Radhakrishnan Murali Naidu
7,12-Dimethylbenz(a)anthracene (DMBA)-induced hamster buccal pouch carcinogenesis is widely preferred to assess the tumor-inhibiting efficacy of the medicinal plants or their constituents. The present study explores the tumor-inhibiting potential of esculetin by utilizing the status of lipid peroxidation by products (thiobarbituric acid reactive substances), antioxidants (vitamin E, reduced glutathione, superoxide dismutase, catalase, and glutathione peroxidase), and phase I and phase II detoxification agents as biochemical end points and by using histopathological studies as well in DMBA-induced hamster buccal pouch carcinogenesis...
February 12, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29433684/short-and-long-term-modulation-of-tissue-minerals-concentrations-following-oral-administration-of-black-cumin-nigella-sativa-l-seed-oil-to-laboratory-rats
#20
Irum Basheer, Irfan Zia Qureshi
BACKGROUND: Nigella sativa, or commonly called black cumin is a small herb of family Ranunculaceae is a well-known medicinal plant but its effects on tissue mineral concentrations of animal bodies is unknown. PURPOSE: To study the effect of oral administration of fixed oil of black cumin seeds on tissues mineral content using laboratory rats as experimental model. STUDY DESIGN: Experimental animals were exposed to two oral doses of seed oil (60 and 120 ml kg -1 body weight)...
January 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
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