Tony S Eteläinen, M Catarina Silva, Johanna K Uhari-Väänänen, Francesca De Lorenzo, Maria H Jäntti, Hengjing Cui, Marta Chavero-Pieres, Tommi Kilpeläinen, Christina Mechtler, Reinis Svarcbahs, Erin Seppälä, Juha R Savinainen, Elena Puris, Gert Fricker, Mikko Gynther, Ulrika H Julku, Henri J Huttunen, Stephen J Haggarty, Timo T Myöhänen
Tauopathies are neurodegenerative diseases that are characterized by accumulation of hyperphosphorylated tau protein, higher-order aggregates, and tau filaments. Protein phosphatase 2A (PP2A) is a major tau dephosphorylating phosphatase, and a decrease in its activity has been demonstrated in tauopathies, including Alzheimer's disease. Prolyl oligopeptidase is a serine protease that is associated with neurodegeneration, and its inhibition normalizes PP2A activity without toxicity under pathological conditions...
April 12, 2023: Science Translational Medicine