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clonidine bupivacaine

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https://www.readbyqxmd.com/read/27795779/postoperative-analgesia-in-children-when-using-clonidine-in-addition-to-fentanyl-with-bupivacaine-given-caudally
#1
Anouar Jarraya, Sahar Elleuch, Jawhar Zouari, Mohamed Smaoui, Sofiene Laabidi, Kamel Kolsi
The aim of the study was to evaluate the efficacy of clonidine in association with fentanyl as an additive to bupivacaine 0.25% given via single shot caudal epidural in pediatric patients for postoperative pain relief. In the present prospective randomized double blind study, 40 children of ASA-I-II aged 1-5 years scheduled for infraumblical surgical procedures were randomly allocated to two groups to receive either bupivacaine 0.25% (1 ml/kg) with fentanyl 1 μg/kg and clonidine 1μg/kg (group I) or bupivacaine 0...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27790555/efficacy-and-safety-of-clonidine-as-an-adjuvant-to-bupivacaine-for-caudal-analgesia-in-paediatric-infra-umbilical-surgeries
#2
Samita Priolkar, Shirley Ann D'Souza
INTRODUCTION: Caudal analgesia, has gained popularity in paediatric intraoperative and postoperative pain management, more so with the use of adjuvants to prolong its duration, each of them having various results. Clonidine, an alpha2-adrenergic agonist is being used for its analgesic effects in various doses with 0.25% Bupivacaine. AIM: The study was conducted to compare the analgesic efficacy, haemodynamic safety and side effects of 1 μg/kg Clonidine added to 1 ml/kg of 0...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27778056/-unilateral-spinal-anesthesia-literature-review-and-recommendations
#3
B Büttner, A Mansur, M Bauer, J Hinz, I Bergmann
Unilateral spinal anesthesia is a cost-effective and rapidly performed anesthetic technique. An exclusively unilateral block only affects the sensory, motor and sympathetic functions on one side of the body and offers the advantages of a spinal block without the typical adverse side effects seen with a bilateral block. The lack of hypotension, in particular, makes unilateral spinal anesthesia suitable for patients with cardiovascular risk factors e. g. aortic valve stenosis or coronary artery disease. Increasing numbers of surgical procedures are now being performed on an outpatient basis...
October 24, 2016: Der Anaesthesist
https://www.readbyqxmd.com/read/27746562/a-comparative-study-on-effect-of-addition-of-clonidine-and-fentanyl-as-adjuvants-to-local-anaesthetics-for-subarachnoid-block-in-patients-undergoing-lumbar-laminectomies
#4
Umesh K Dash, S Kiran, Urvashi Tandon, Kavitha Jinjil
BACKGROUND: The synergism between local anesthetic agents such as bupivacaine with intrathecal adjuvants such as opioids and clonidine is well established. AIMS: This study evaluates the clinical efficacy of clonidine75 μg versus fentanyl 25 μg as adjuvants to bupivacaine for spinal anesthesia. SETTINGS AND DESIGN: A prospective, randomized, parallel arm study was conducted over a period of 12 months in a tertiary care hospital. MATERIALS AND METHODS: Sixty patients were divided randomly into two groups, Group C and Group F...
September 2016: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/27746546/comparison-of-clonidine-and-fentanyl-as-adjuvant-to-ropivacaine-in-spinal-anesthesia-in-lower-abdominal-surgeries
#5
Radhe Sharan, Rajan Verma, Akshay Dhawan, Jugal Kumar
BACKGROUND: Ropivacaine, a newer local anesthetic, is gaining increased acceptance due to its improved safety profile over bupivacaine and lignocaine. Analgesic adjuvants have proved to be valuable in improving the quality of anesthesia and duration of analgesia. AIM: To compare the efficacy of clonidine and fentanyl as adjuvants to ropivacaine in spinal anesthesia in lower abdominal surgeries. MATERIALS AND METHODS: A randomized, double-blind control study was carried out in 100 patients who were randomly divided into two groups...
September 2016: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/27746540/effect-of-intravenous-dexmedetomidine-on-spinal-anaesthesia-with-0-5-hyperbaric-bupivacaine-in-lower-abdominal-surgeries-a-prospective-randomized-control-study
#6
Madhavi Unmesh Santpur, Govind Marutrao Kahalekar, Nowreen Saraf, Aparna Losari
BACKGROUND: Regional anesthesia is the preferred technique for most of lower abdominal and lower limb surgeries. For decades, lignocaine had been the local anesthetic of choice for spinal anesthesia. Recent studies show that intravenous clonidine and dexmedetomidine can prolong the duration of the spinal anesthesia. Dexmedetomidine is a more suitable adjuvant compared to clonidine due to its more selective α2A receptor agonist activity. AIM: The study was undertaken to evaluate the effects of intravenous administration of dexmedetomidine on spinal anesthesia with 0...
September 2016: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/27746535/the-effect-of-multimodal-analgesia-on-minimum-alveolar-concentration-of-isoflurane-for-skin-incision-at-constant-bispectral-index
#7
Keelara Shivalingaiah Savitha, Radhika Dhanpal, J Shilpa
BACKGROUND: Multimodal analgesia (MMA) by synergy with volatile anesthetics minimizes their use thus decreasing operation theater pollution and greenhouse gas emission. AIMS: To estimate minimum alveolar concentration (MAC) requirement of isoflurane (ISO) for skin incision with use of MMA in the study group versus conventional regime in the control group for a constant bispectral index (BIS). To observe the side effects of analgesic drugs administered in the study...
September 2016: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/27746532/comparison-of-spinal-block-after-intrathecal-clonidine-bupivacaine-buprenorphine-bupivacaine-and-bupivacaine-alone-in-lower-limb-surgeries
#8
Major Vishal Arora, Mohammad Zafeer Khan, Major Sanjay Choubey, Mohammad Asim Rasheed, Arindam Sarkar
CONTEXT: Various adjuvants are being used with local anesthetics for prolongation of intraoperative and postoperative analgesia. The α2-adrenergic agonist clonidine and potent opioid buprenorphine have the ability to potentiate the effects of local anesthetics. AIMS: The purpose of this prospective, double-blind study was to compare onset, duration of sensory and motor block, effect on hemodynamics, level of sedation, duration of postoperative analgesia, and any adverse effects of clonidine and buprenorphine...
September 2016: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/27746531/effect-of-adding-clonidine-to-intrathecal-bupivacaine-on-the-quality-of-subarachnoid-block-a-prospective-randomized-double-blind-study
#9
Srivishnu Vardhan Yallapragada, Nagendra Nath Vemuri, Mastan Saheb Shaik
CONTEXT: The purpose of adding an adjuvant to local anesthetic in a central neuraxial blockade is to augment the desirable pharmacological actions of the agent and/or to minimize its undesirable pharmacological effects. Clonidine is an alfa-2 receptor agonist which has gained popularity in recent times as an adjuvant in spinal anesthesia. AIMS: To evaluate the influence of clonidine on the hemodynamic stability and the duration of anesthesia when added to intrathecal hyperbaric bupivacaine...
September 2016: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/27746524/evaluation-of-clonidine-as-an-adjuvant-to-bupivacaine-in-wound-infiltration-for-providing-postoperative-analgesia-after-abdominal-hysterectomy
#10
Venkatesh Selvaraj
BACKGROUND: Clonidine is an effective adjuvant to local anesthetics in peripheral nerve blocks. We studied the effect of clonidine as an adjuvant in wound infiltration for postoperative analgesia. AIM: To evaluate the role of clonidine as an adjuvant to bupivacaine in wound infiltration in terms of quality and duration of postoperative analgesia in patients undergoing total abdominal hysterectomy. SETTINGS AND STUDY DESIGN: Prospective, randomized, double-blinded study...
September 2016: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/27676680/intrathecal-bupivacaine-monotherapy-with-a-retrograde-catheter-for-the-management-of-complex-regional-pain-syndrome-of-the-lower-extremity
#11
W Porter McRoberts, Catalina Apostol, Abdul Haleem
UNLABELLED: Complex regional pain syndrome (CRPS) presents a therapeutic challenge due to its many presentations and multifaceted pathophysiology. There is no approved treatment algorithm and clinical interventions are often applied empirically. In cases of CRPS where symptoms are localized to an extremity, a targeted treatment is indicated. We describe the use of intrathecal bupivacaine monotherapy, delivered through a retrograde catheter, in the treatment of CRPS affecting the lower extremity...
September 2016: Pain Physician
https://www.readbyqxmd.com/read/27625483/a-comparative-study-of-clonidine-and-dexmedetomidine-as-an-adjunct-to-bupivacaine-in-supraclavicular-brachial-plexus-block
#12
Archana Tripathi, Khushboo Sharma, Mukesh Somvanshi, Rajib Lochan Samal
BACKGROUND AND AIMS: Various additives are mixed with local anesthetic agents to increase the quality of block in regional anesthesia. We compared clonidine and dexmedetomidine as an adjunct to bupivacaine in supraclavicular brachial plexus block with respect to the onset and duration of sensory and motor block and duration of analgesia. MATERIAL AND METHODS: Sixty American Society of Anesthesiologists Grades I and II patients scheduled for various orthopedic surgeries of the upper limb under supraclavicular brachial plexus block were divided into two equal groups in a randomized, double-blind manner...
July 2016: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/27625482/comparison-of-block-characteristics-of-spinal-anesthesia-following-intravenous-dexmedetomidine-and-clonidine
#13
Akansha Agrawal, Sanjay Agrawal, Yashwant S Payal
BACKGROUND AND AIMS: Different routes of administration of α2 adrenergic receptor agonists have been found to prolong the duration of spinal block. MATERIAL AND METHODS: One hundred and twenty patients, aged 18-60 years, of ASA physical status I or II posted for elective fixation of fractures of lower limb under spinal anesthesia were selected. Spinal anesthesia was administered with 2.5 ml of 0.5% bupivacaine mixed with 10 μg fentanyl. The patients were randomized to receive intravenous (IV) dexmedetomidine 1 μg/kg/h for 15 min followed by infusion of 0...
July 2016: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/27555198/randomized-study-of-postcesarean-analgesia-with-intrathecal-morphine-alone-or-combined-with-clonidine
#14
Francisco A E Carvalho, Sérgio B Tenório, Fabiano T Shiohara, Luiz R Maia, Angela Mota
STUDY OBJECTIVE: To investigate the efficacy of the combination of intrathecal morphine with clonidine in comparison with 2 doses of intrathecal morphine alone for postcesarean analgesia. DESIGN: Prospective, double-blinded, randomized clinical trial. SETTING: Maternity ward of Hospital Santa Cruz, Curitiba, Paraná, Brazil (operating room and ward). PATIENTS: The study included 195 American Society of Anesthesiologist I to III singleton parturients undergoing elective cesarean section...
September 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27550952/dexamethasone-and-clonidine-but-not-epinephrine-prolong-duration-of-ropivacaine-brachial-plexus-blocks-cross-sectional-analysis-in-outpatient-surgery-setting
#15
Nahel N Saied, Rajnish K Gupta, Lina Saffour, Mohammad A Helwani
OBJECTIVE: The primary aim of this study is to determine the effect of adding dexamethasone, clonidine or both with and without epinephrine to ropivacaine and bupivacaine brachial plexus blocks. DESIGN: Observational study of prospectively collected data SETTING: Single academic outpatient surgery center METHODS: We evaluated 5,515 patient entries who received brachial plexus block (BPB). Multiple, rescue, unsuccessful, and distal nerve blocks of the upper extremity were excluded...
August 22, 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/27550555/caudal-analgesia-and-cardiothoracic-surgery-a-look-at-postoperative-pain-scores-in-a-pediatric-population
#16
Khoa N Nguyen, Heather S Byrd, Jonathan M Tan
AIM: Caudal epidural anesthesia has been shown to reduce stress response and shorten the time to extubation in children after cardiac surgery. Combined with general anesthesia, regional anesthesia has been proven to be safe and efficacious in the pediatric population. It is not known, however, whether the use of caudal anesthesia actually reduces postoperative pain scores and decreases postoperative opioid use. METHODS: We retrospectively analyzed the charts of 199 children who underwent repair for atrial septal defect (ASD), ventricular septal defect (VSD), and Tetralogy of Fallot (TOF) at a major academic children's hospital between 2010 and 2013...
November 2016: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/27513275/the-effects-of-bupivacaine-combined-with-different-adjuvants-on-block-onset-and-duration-and-on-ion-channel-expressions-scn9a-trpm-in-sciatic-nerve-block-in-rats
#17
Nurgül Dolu, Levent Şahin, Davut Sinan Kaplan, Tuncer Demir, Hasan Şimşek, Mehrican Şahin, Beyhan Cengiz
BACKGROUND/AIM: The objective of this experimental study was to examine the effects of epinephrine, dexmedetomidine, and clonidine added as adjuvants to bupivacaine on block onset and effect times, as well as the effects on the Na+ and Ca+2 channel gene expressions, which may indicate cell damage in the sciatic nerve cell membrane. MATERIALS AND METHODS: Rats were divided into five groups: Group S (sham), saline solution; Group B, bupivacaine; Group BD, bupivacaine + dexmedetomidine; Group BC, bupivacaine + clonidine; and Group BE, bupivacaine + epinephrine...
April 19, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/27491573/spontaneous-osteonecrosis-of-the-jaw-during-bisphosphonate-therapy-an-unusual-etiology-of-the-numb-chin-syndrome
#18
Tanja Fusi-Schmidhauser, Donata Bardelli
The numb chin syndrome is a rare manifestation of intractable pain in the palliative care setting and represents a major therapeutic challenge. The reported etiologies of the numb chin syndrome include trauma, infections, immune-mediated systemic conditions, and malignancy, both through local infiltration or compression of the inferior alveolar nerve sheath. The authors present the case of a patient with long-standing multiple myeloma, suffering from numb chin syndrome caused by a spontaneous osteonecrosis of the jaw after bisphosphonate therapy...
September 2016: Journal of Pain & Palliative Care Pharmacotherapy
https://www.readbyqxmd.com/read/27474362/identification-of-drugs-in-parenteral-pharmaceutical-preparations-from-a-quality-assurance-and-a-diversion-program-by-direct-analysis-in-real-time-accutoftm-mass-spectrometry-dart-ms
#19
Justin L Poklis, Amanda J Mohs, Carl E Wolf, Alphonse Poklis, Michelle R Peace
In healthcare settings drug diversion and impairment of physicians are major concerns requiring a rapid and efficient method for surveillance and detection. A Direct Analysis in Real Time ion source coupled to a JEOL AccuTOF(TM) time-of-flight mass spectrometer (DART-MS) method was developed to screen parenteral pharmaceutical formulations for potential drug diversion. Parenteral pharmaceutical formulations are also known as injectable formulations and are used with intravenous, subcutaneous, intramuscular and intra-articular administration...
October 2016: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/27347302/the-analgesic-effect-of-clonidine-as-an-adjuvant-in-dorsal-penile-nerve-block
#20
Jarraya Anouar, Smaoui Mohamed, Abidi Sofiene, Zouari Jawhar, Elleuch Sahar, Kolsi Kamel
INTRODUCTION: Dorsal penile nerve block (DPNB) is a commonly performed regional anesthetic technique for male circumcision. The aim of this study was to assess the analgesic effect of the adjunction of clonidine to bupivacaine 0.5% in this block. METHODS: It was a prospective randomized double-blind clinical trial including 40 ASA1 boys aged from 1 to 4 years undergoing elective circumcision. Dorsal penile nerve block was performed under general Anesthesia. Patients were randomized in two groups: Group 1 (G1): received 0...
2016: Pan African Medical Journal
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