Samantha Durbin, Lindsey Loss, Lydia Buzzard, Karen Minoza, Marissa Beiling, Carmen Karsonovich, Moqing Liu, Joseph Garay, Alexander Fields, Michael Mathews, Benjamin Kuhn, Keith Moskowitz, Byron Miyazawa, Alpa Trivedi, Lucy Kornblith, Michael Fitzpatrick, Shibani Pati, Martin Schreiber
BACKGROUND: Hemorrhage accounts for the most preventable deaths after trauma. Resuscitation is guided by studies that demonstrate improved outcomes in patients receiving whole blood or balanced administration of blood products. Platelets present a logistical challenge due to short shelf life and need for refrigeration. Platelet derived extracellular vesicles (PEVs) are a possible platelet alternative. PEVs are secreted from platelets, have hemostatic effects and mitigate inflammation and vascular injury, similar to platelets...
November 27, 2023: Journal of Trauma and Acute Care Surgery